Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEJKRF)

• Drug Name: Motexafin gadolinium Drug Info
• Synonyms: Xcytrin; Gadolinium texaphyrin; GdT2B2; GD-Tex; Motexafin gadolinium (USAN); PCI-0120; Xcytrin (TN)

Indication

Disease Entry	ICD 11	Status	REF
Brain cancer	2A00	Approved	[1]
Human immunodeficiency virus infection	1C62	Phase 3	[2]

• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 158385
  CAS Number: CAS 246252-06-2
  TTD Drug ID: DMEJKRF

Molecule-Related Drug Atlas

Drug(s) Targeting Thioredoxin reductase (PRDX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eptacog beta	DMTY96S	Chronic lymphocytic leukaemia	2A82.0	Phase 1/2	[4]
Diterpene triepoxide derivative 1	DMYQHER	N. A.	N. A.	Patented	[5]

Drug(s) Affected By Metallothionein-2 (MT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[6]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[8]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[10]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[11]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[12]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[13]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[14]

Drug(s) Affected By Metallothionein-1E (MT1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[16]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[19]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[20]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[21]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[22]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]

Drug(s) Affected By Metallothionein-1F (MT1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[12]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[28]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[19]

Drug(s) Affected By Metallothionein 1H-like protein 1 (MT1HL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[28]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[30]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[31]
Lead acetate	DML0GZ2	Discovery agent	N.A.	Investigative	[32]

Drug(s) Affected By Metallothionein-1G (MT1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[34]

Drug(s) Affected By Metallothionein-1H (MT1H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[8]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[35]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[28]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[36]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[22]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]

Drug(s) Affected By Metallothionein-1X (MT1X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[12]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF19B (RNF19B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[28]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]

Drug(s) Affected By Proton-coupled zinc antiporter SLC30A1 (SLC30A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[7]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]

Drug(s) Affected By Activator of apoptosis harakiri (HRK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[55]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[56]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Methamphetamine	DMPM4SK	Anxiety		Approved	[57]

Drug(s) Affected By Transcription factor E2F3 (E2F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[63]

Drug(s) Affected By Programmed cell death protein 5 (PDCD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[62]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[67]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[68]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[40]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[69]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Selenium	DM25CGV	N. A.	N. A.	Approved	[73]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[40]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[74]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[74]

Drug(s) Affected By Transcription regulator protein BACH1 (BACH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[79]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[81]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[83]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[84]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[44]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[85]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[87]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[88]

Drug(s) Affected By Monocarboxylate transporter 7 (SLC16A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[89]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[90]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[14]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]

Drug(s) Affected By Death-associated protein kinase 3 (DAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[93]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[94]

Drug(s) Affected By Forkhead box protein O3 (FOXO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[95]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[99]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[12]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[101]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[105]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[106]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[107]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]

Drug(s) Affected By SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[110]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[111]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[112]

Drug(s) Affected By HMG box-containing protein 1 (HBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By DnaJ homolog subfamily B member 6 (DNAJB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[113]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[20]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[115]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[110]

Drug(s) Affected By Large neutral amino acids transporter small subunit 3 (SLC43A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[116]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[118]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[119]

Drug(s) Affected By E3 SUMO-protein ligase PIAS1 (PIAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[121]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[122]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[91]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[123]

Drug(s) Affected By DNA fragmentation factor subunit beta (DFFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[89]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]

Drug(s) Affected By Glutaminase kidney isoform, mitochondrial (GLS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[126]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[127]

Drug(s) Affected By Elongator complex protein 1 (ELP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[56]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[111]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[128]

Drug(s) Affected By RCC1 and BTB domain-containing protein 2 (RCBTB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[131]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[31]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[132]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[101]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 8 (TNFAIP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[14]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By NAD kinase (NADK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Bortezomib	DMNO38U	Leukemia		Approved	[135]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[111]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[112]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[91]

Drug(s) Affected By Heat shock 70 kDa protein 4L (HSPA4L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[137]

Drug(s) Affected By BAG family molecular chaperone regulator 3 (BAG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[138]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[62]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[139]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[141]
Ketoprofen	DMRKXPT	Bursitis		Approved	[128]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[143]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[145]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]

Drug(s) Affected By Phosphoglycerate kinase 1 (PGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[12]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Transferrin receptor protein 1 (TFRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[156]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[159]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[160]

Drug(s) Affected By Heat shock protein beta-1 (HSPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[161]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[49]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[165]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[166]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[168]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[169]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[171]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[172]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]

Drug(s) Affected By Alpha-enolase (ENO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[149]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[178]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[13]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[14]

Drug(s) Affected By Protein disulfide-isomerase (P4HB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[179]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[149]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[180]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[179]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[103]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[116]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[49]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[14]

Drug(s) Affected By Heat shock protein HSP 90-beta (HSP90AB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[182]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[156]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[11]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[184]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[185]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[186]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[187]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[188]
Selenium	DM25CGV	N. A.	N. A.	Approved	[189]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[190]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[191]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[193]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[8]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[149]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[11]

Drug(s) Affected By 60 kDa heat shock protein, mitochondrial (HSPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[182]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[149]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[196]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[11]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[197]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[198]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[199]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[201]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[8]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[203]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[128]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[205]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[206]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[208]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[209]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[210]

Drug(s) Affected By Neurofibromin (NF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[51]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[211]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[111]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[212]

Drug(s) Affected By cAMP-dependent protein kinase catalytic subunit beta (PRKACB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[135]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[213]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[115]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[94]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[214]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[215]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[216]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Selenium	DM25CGV	N. A.	N. A.	Approved	[218]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[219]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[220]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[221]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]

Drug(s) Affected By DnaJ homolog subfamily B member 1 (DNAJB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[116]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[199]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[223]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[224]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[13]

Drug(s) Affected By Calnexin (CANX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[225]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[107]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[228]

Drug(s) Affected By Cell division cycle protein 27 homolog (CDC27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[229]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[112]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[31]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[68]

Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[214]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]

Drug(s) Affected By High affinity cationic amino acid transporter 1 (SLC7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[14]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]

Drug(s) Affected By Cystathionine gamma-lyase (CTH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[89]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[15]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[14]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 8 (TNFSF8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[62]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[135]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[232]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[233]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[234]
PF-3758309	DM36PKZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[235]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[236]

Drug(s) Affected By Heat shock 70 kDa protein 4 (HSPA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[237]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[133]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[238]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[11]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]

Drug(s) Affected By Glycogen debranching enzyme (AGL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[240]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[136]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[241]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[71]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[8]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[242]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[243]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[244]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[246]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[247]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[248]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[249]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[250]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[252]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[253]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[254]

Drug(s) Affected By Neutral amino acid transporter A (SLC1A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[14]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[14]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[255]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[256]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[257]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[258]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[259]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[260]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[261]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[262]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[263]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[264]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[265]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[266]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[267]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[268]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[269]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[179]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[272]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[273]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[274]

Drug(s) Affected By Transcription activator BRG1 (SMARCA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[275]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[211]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[20]

Drug(s) Affected By Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Bortezomib	DMNO38U	Leukemia		Approved	[135]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[121]

Drug(s) Affected By Monocarboxylate transporter 1 (SLC16A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[273]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[273]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[51]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[44]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[276]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]

Drug(s) Affected By Sestrin-2 (SESN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[277]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[244]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[103]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[116]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[278]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[15]

Drug(s) Affected By Selenoprotein W (SELENOW)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[279]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[280]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[20]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[102]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[110]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[136]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[112]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[31]

Drug(s) Affected By DNA-dependent protein kinase catalytic subunit (PRKDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[182]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[225]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[282]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[49]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[283]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[28]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[284]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[284]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[285]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[286]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[287]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[288]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[289]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[7]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[216]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[290]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[40]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[172]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[103]

Drug(s) Affected By Transcription factor RelB (RELB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[291]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[292]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[224]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[28]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[62]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[293]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[294]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[295]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[236]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[28]

Drug(s) Affected By Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase , mitochondrial (ALDH6A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[296]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[297]

Drug(s) Affected By DNA-binding protein inhibitor ID-2 (ID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[298]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[299]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[116]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[298]

Drug(s) Affected By Protein kinase C delta type (PRKCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[300]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[301]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[302]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[303]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[49]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[304]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[305]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[306]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[307]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[106]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[223]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[304]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[14]

Drug(s) Affected By Cell division cycle protein 16 homolog (CDC16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[305]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[20]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[136]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[112]

Drug(s) Affected By FAS-associated death domain protein (FADD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[7]
Selenium	DM25CGV	N. A.	N. A.	Approved	[308]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[309]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[310]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[35]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[311]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[223]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[49]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[283]

Drug(s) Affected By DnaJ homolog subfamily C member 3 (DNAJC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[312]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[304]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[313]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[314]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[315]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[316]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[317]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[99]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[318]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[319]

Drug(s) Affected By Serine/threonine-protein kinase ATR (ATR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[320]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[321]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[283]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[322]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]

Drug(s) Affected By Cullin-3 (CUL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[51]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[323]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[228]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[324]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[325]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[83]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[326]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[327]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[328]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[329]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]

Drug(s) Affected By Core-binding factor subunit beta (CBFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[330]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[305]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[102]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[331]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[332]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[49]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[34]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[333]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[94]

Drug(s) Affected By Helicase-like transcription factor (HLTF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[304]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[334]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[111]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[335]

Drug(s) Affected By Protein RRP5 homolog (PDCD11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[305]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[228]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[336]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[336]

Drug(s) Affected By Nuclear receptor subfamily 1 group D member 2 (NR1D2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[312]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[297]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[94]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[338]

Drug(s) Affected By Metal cation symporter ZIP14 (SLC39A14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[312]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[339]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[340]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[341]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[342]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[342]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[343]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[344]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[345]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[281]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[346]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[347]

Drug(s) Affected By 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[348]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[44]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[349]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[33]

Drug(s) Affected By 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[350]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[14]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[28]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[137]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[34]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[36]

Drug(s) Affected By S-adenosylmethionine sensor upstream of mTORC1 (BMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[351]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[352]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[353]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[51]

Drug(s) Affected By Programmed cell death protein 4 (PDCD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[354]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[355]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[354]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[356]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[89]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[354]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[304]

Drug(s) Affected By Cyclin-J (CCNJ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[44]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[333]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[357]

Drug(s) Affected By Rho GTPase-activating protein 17 (ARHGAP17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[112]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[351]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[236]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[132]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[359]

Drug(s) Affected By Cell division cycle-associated protein 2 (CDCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[278]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[313]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[28]

Drug(s) Affected By Interferon regulatory factor 2-binding protein 2 (IRF2BP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[297]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[111]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[112]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[31]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[305]

Drug(s) Affected By Homeodomain-interacting protein kinase 1 (HIPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[312]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[360]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[136]

Drug(s) Affected By T-cell activation Rho GTPase-activating protein (TAGAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[361]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[338]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[362]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[236]

Drug(s) Affected By Protein PHTF2 (PHTF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[229]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[112]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[351]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[363]

Drug(s) Affected By TNFAIP3-interacting protein 2 (TNIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[364]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[112]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[236]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[132]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[92]

Drug(s) Affected By Alanine aminotransferase 2 (GPT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[116]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[240]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]

Drug(s) Affected By General transcription factor 3C polypeptide 2 (GTF3C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Bortezomib	DMNO38U	Leukemia		Approved	[135]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[111]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[365]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[366]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[92]

Drug(s) Affected By DNA-binding death effector domain-containing protein 2 (DEDD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Bortezomib	DMNO38U	Leukemia		Approved	[367]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[368]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[111]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[357]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[351]

Drug(s) Affected By Heat shock protein 105 kDa (HSPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[11]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[116]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[224]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[369]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]

Drug(s) Affected By Protein FAM162A (FAM162A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[14]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]

Drug(s) Affected By Probable G-protein coupled receptor 146 (GPR146)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[111]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[357]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[370]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[132]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[371]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[372]

Drug(s) Affected By Phosphoinositide-3-kinase-interacting protein 1 (PIK3IP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Idelalisib	DM602WT	Chronic lymphocytic leukaemia	2A82.0	Approved	[374]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[89]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[361]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[297]

Drug(s) Affected By Sodium-coupled neutral amino acid symporter 2 (SLC38A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[346]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[375]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]

Drug(s) Affected By Tribbles homolog 3 (TRIB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[116]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[266]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[89]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[224]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[49]

Drug(s) Affected By Cell division cycle 5-like protein (CDC5L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[376]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[377]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[378]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[123]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]

Drug(s) Affected By Myeloid differentiation primary response protein MyD88 (MYD88)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[20]

Drug(s) Affected By Cyclin-dependent kinase 19 (CDK19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[44]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[312]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[20]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[229]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[357]

Drug(s) Affected By Serine/threonine-protein kinase D2 (PRKD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[338]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[365]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[305]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[351]

Drug(s) Affected By Egl nine homolog 1 (EGLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[379]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[137]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[94]

Drug(s) Affected By MOB kinase activator 1A (MOB1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[20]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[110]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[229]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[31]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[378]

Drug(s) Affected By Zinc transporter ZIP9 (SLC39A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[380]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[339]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[136]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[112]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[108]

Drug(s) Affected By Fas apoptotic inhibitory molecule 1 (FAIM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[36]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[111]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[381]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[382]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[12]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[278]

Drug(s) Affected By 7-dehydrocholesterol reductase (DHCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[383]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[346]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[13]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[240]

Drug(s) Affected By DnaJ homolog subfamily B member 4 (DNAJB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[11]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[116]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[267]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[224]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[15]

Drug(s) Affected By NADH-cytochrome b5 reductase 1 (CYB5R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[228]
Bortezomib	DMNO38U	Leukemia		Approved	[135]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[229]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[128]

Drug(s) Affected By Zinc transporter ZIP10 (SLC39A10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[350]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[339]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[384]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[384]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[384]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[385]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[116]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[384]

Drug(s) Affected By Nischarin (NISCH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[386]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[20]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[112]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[387]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[388]

Drug(s) Affected By Peptidyl-tRNA hydrolase 2, mitochondrial (PTRH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[389]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[305]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[112]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[390]

Drug(s) Affected By Lysine-specific demethylase 3A (KDM3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[325]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[391]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[14]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]

Drug(s) Affected By Hypoxia-inducible lipid droplet-associated protein (HILPDA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[41]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thioredoxin reductase (PRDX5)	TTLPJWH	PRDX5_HUMAN	Modulator	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)	OT25JBA3	F263_HUMAN	Gene/Protein Processing	[3]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)	OTQYEXL2	F264_HUMAN	Gene/Protein Processing	[3]
60 kDa heat shock protein, mitochondrial (HSPD1)	OTTO1Y11	CH60_HUMAN	Gene/Protein Processing	[3]
7-dehydrocholesterol reductase (DHCR7)	OTLILBUI	DHCR7_HUMAN	Gene/Protein Processing	[3]
Activator of apoptosis harakiri (HRK)	OTR4GWJ0	HRK_HUMAN	Gene/Protein Processing	[3]
Alanine aminotransferase 2 (GPT2)	OTS5VF7N	ALAT2_HUMAN	Gene/Protein Processing	[3]
Alpha-enolase (ENO1)	OTB1KWJS	ENOA_HUMAN	Gene/Protein Processing	[3]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Gene/Protein Processing	[3]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[3]
BAG family molecular chaperone regulator 3 (BAG3)	OTVXYUDQ	BAG3_HUMAN	Gene/Protein Processing	[3]

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