Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4KXT0)

• Drug Name: BRN-3548355 Drug Info
• Synonyms: NNK (carcinogen); 1-Butanone, 4-(methylnitrosoamino)-1-(3-pyridinyl)-; 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE; 4-(Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; 4-(N-Nitroso-N-methylamino)-1-(3-pyridyl)-1-butanone; 4-Methylnitrosoamino-1-(3-pyridinyl)-1-butanone; 4-[methyl(nitroso)amino]-1-(pyridin-3-yl)butan-1-one; 64091-91-4; 7S395EDO61; CCRIS 1150; CHEBI:32692; MFCD00274580; N-Methyl-N-nitroso-4-oxo-4-(3-pyridyl)butyl amine; NNK; UNII-7S395EDO61
• Cross-matching ID:
  PubChem CID: 47289
  ChEBI ID: CHEBI:32692
  CAS Number: CAS 64091-50-5
  TTD Drug ID: DM4KXT0
  INTEDE Drug ID: DR0011

Molecule-Related Drug Atlas

Drug(s) Metabolized By NADPH-dependent carbonyl reductase 1 (CBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[8]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[9]
FENOFIBRIC ACID	DMGO2MC	Cardiovascular disease	BA00-BE2Z	Approved	[10]
PGF2alpha	DM4XAU7	Solid tumour/cancer	2A00-2F9Z	Clinical trial	[11]
VUFB-11502	DM7WFR0	N. A.	N. A.	Preclinical	[12]
Phenanthrene-9,10-dione	DMG8KS9	Discovery agent	N.A.	Investigative	[13]

Drug(s) Metabolized By Aldo-keto reductase 1C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[14]
FENOFIBRIC ACID	DMGO2MC	Cardiovascular disease	BA00-BE2Z	Approved	[10]
Nabumetone	DMAT2XH	Osteoarthritis	FA00-FA05	Approved	[15]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[14]
Trastuzumab emtansine	DMU1LXS	HER2-positive breast cancer	2C60-2C65	Phase 2	[16]

Drug(s) Metabolized By Aldo-keto reductase 1C4 (AKR1C4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nabumetone	DMAT2XH	Osteoarthritis	FA00-FA05	Approved	[15]
Norethindrone acetate	DMDGCQP	N. A.	N. A.	Approved	[17]
Trastuzumab emtansine	DMU1LXS	HER2-positive breast cancer	2C60-2C65	Phase 2	[16]

Drug(s) Metabolized By Aldo-keto reductase 1C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FENOFIBRIC ACID	DMGO2MC	Cardiovascular disease	BA00-BE2Z	Approved	[10]
Trastuzumab emtansine	DMU1LXS	HER2-positive breast cancer	2C60-2C65	Phase 2	[16]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[18]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[19]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[21]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[22]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[25]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[27]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[28]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[21]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[30]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[23]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[31]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[33]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[31]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[22]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[34]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[35]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[36]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[37]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[42]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[43]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[44]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[46]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[47]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[48]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[34]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[31]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[53]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[54]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[55]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[57]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[59]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[60]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[61]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[64]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[65]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[66]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[69]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[72]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[74]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[75]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[76]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[77]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[60]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[78]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[80]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[83]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]

Drug(s) Affected By GTP-binding protein 1 (GTPBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[90]
Bortezomib	DMNO38U	Leukemia		Approved	[91]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[92]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[93]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[94]

Drug(s) Affected By NPC intracellular cholesterol transporter 1 (NPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[95]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[90]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[101]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]

Drug(s) Affected By Orexin receptor type 2 (HCRTR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[105]

Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[108]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[110]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[110]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]

Drug(s) Affected By Sterol O-acyltransferase 2 (SOAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[115]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[102]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[113]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[94]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[116]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[117]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[118]

Drug(s) Affected By Dickkopf-related protein 1 (DKK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[90]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[124]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[78]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[125]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[81]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[126]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[127]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[129]
Selenium	DM25CGV	N. A.	N. A.	Approved	[130]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[131]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[132]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[128]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[133]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[137]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[64]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]

Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[143]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[144]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[145]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[146]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[148]

Drug(s) Affected By Argininosuccinate lyase (ASL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[143]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[102]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[152]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[153]

Drug(s) Affected By Metallothionein-1F (MT1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[157]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[158]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[159]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[160]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[161]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[21]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[162]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[163]
Selenium	DM25CGV	N. A.	N. A.	Approved	[164]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[38]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[165]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[169]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[170]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[76]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[170]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[171]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[172]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[174]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[175]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[177]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[178]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[179]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[180]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[181]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[182]

Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[129]
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[183]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[184]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[185]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[186]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[187]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[188]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[189]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[190]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[192]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[193]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[89]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[195]
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[196]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[197]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[199]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[200]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[202]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[203]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[208]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[208]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[209]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[210]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-1 (ATF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[212]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[102]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[213]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[212]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[214]
Pelitinib	DMIW453	Lymphoma	2A80-2A86	Phase 2	[215]

Drug(s) Affected By Cadherin-2 (CDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[216]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[218]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[219]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[220]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[221]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[148]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[160]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[222]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[128]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[223]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[224]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[225]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[226]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[227]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[228]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[229]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[230]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[229]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[233]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[229]

Drug(s) Affected By MHC class II regulatory factor RFX1 (RFX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[234]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[153]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[237]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[94]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[238]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[239]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[240]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[241]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[242]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[243]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[244]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[246]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[247]

Drug(s) Affected By Trans-acting T-cell-specific transcription factor GATA-3 (GATA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[216]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[248]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[249]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[89]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[250]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[251]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[253]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[254]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[182]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[255]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[78]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[256]
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[137]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[257]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[258]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[184]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[76]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[65]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[83]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[259]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[260]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[261]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[178]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[262]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[263]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[163]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[264]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[265]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[266]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[267]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]

Drug(s) Affected By Threonine--tRNA ligase 1, cytoplasmic (TARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[268]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[269]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[89]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[270]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[270]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[271]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[272]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[181]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[273]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[274]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[275]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[276]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[277]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[278]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[279]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[272]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[280]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[281]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[282]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[271]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[178]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[263]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[181]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[273]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[283]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[284]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[182]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[285]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[242]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[286]
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[183]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[137]

Drug(s) Affected By Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[287]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[288]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[290]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[93]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[291]
Carbachol	DMX9K8F	Glaucoma/ocular hypertension	9C61	Approved	[292]
Cotinine	DMCEZ1B	Insecticide	N.A.	Approved	[288]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[94]

Drug(s) Affected By Flap endonuclease 1 (FEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[293]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[110]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[110]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[294]

Drug(s) Affected By DNA mismatch repair protein Mlh1 (MLH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[223]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[115]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[295]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[102]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[296]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[297]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[298]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[299]

Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[269]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[300]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[226]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[301]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[302]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[303]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[18]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[304]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[305]

Drug(s) Affected By DNA mismatch repair protein Msh2 (MSH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[306]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[307]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[308]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[90]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[309]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[310]

Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[311]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[312]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[313]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[314]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[315]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[308]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[316]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[219]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[123]

Drug(s) Affected By Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[108]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[318]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[101]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[102]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[290]

Drug(s) Affected By 6-phosphogluconate dehydrogenase, decarboxylating (PGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[320]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[90]
Methylene blue	DMJAPE7	Acquired methemoglobinemia	3A93	Approved	[321]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[320]

Drug(s) Affected By Death-associated protein kinase 1 (DAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[110]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[322]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[323]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[324]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[325]

Drug(s) Affected By UV excision repair protein RAD23 homolog B (RAD23B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[90]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[323]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[326]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[327]
Indomethacin	DMSC4A7	Bursitis		Approved	[328]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[113]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[329]

Drug(s) Affected By Tumor protein D52 (TPD52)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[229]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[143]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[229]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[251]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[90]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[330]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[174]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[262]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[179]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[188]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[331]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[185]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[76]

Drug(s) Affected By Contactin-1 (CNTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[332]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[90]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[333]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[101]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[333]

Drug(s) Affected By TP53-binding protein 1 (TP53BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[313]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[334]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[90]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[335]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[336]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[337]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[338]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[93]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[339]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[262]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[340]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[169]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[341]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[252]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[342]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[233]

Drug(s) Affected By Transcription factor HES-1 (HES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[343]
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[143]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[235]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[110]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]

Drug(s) Affected By Leukotriene B4 receptor 1 (LTB4R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[344]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[345]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[251]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[346]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[347]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[348]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[245]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[105]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[158]

Drug(s) Affected By Occludin (OCLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[349]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[225]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[350]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[351]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[235]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[352]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[251]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[353]

Drug(s) Affected By Histone H3.1t (H3-4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[354]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[355]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[356]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[357]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[358]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[359]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[360]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[361]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[362]

Drug(s) Affected By Programmed cell death protein 4 (PDCD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[229]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[363]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[229]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[143]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[364]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[304]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[229]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[235]

Drug(s) Affected By Nipped-B-like protein (NIPBL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[313]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[108]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[365]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[237]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[94]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[366]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[149]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 1-like (CHD1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[115]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[102]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[94]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[367]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[105]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[368]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[313]

Drug(s) Affected By Sodium/hydrogen exchanger 9 (SLC9A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[158]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[101]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[369]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[370]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[290]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[93]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[115]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[98]

Drug(s) Affected By COMM domain-containing protein 1 (COMMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[371]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[368]
CLIOQUINOL	DM746BZ	N. A.	N. A.	Withdrawn from market	[372]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[373]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[340]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[374]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[262]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[263]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[375]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[376]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[377]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[341]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[378]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[379]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[144]

Drug(s) Affected By FAST kinase domain-containing protein 4 (TBRG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[90]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[370]

Drug(s) Affected By Serine/threonine-protein kinase SMG1 (SMG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[305]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[380]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[102]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[153]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[290]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[381]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[382]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[383]

Drug(s) Affected By Protein adenylyltransferase SelO, mitochondrial (SELENOO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[98]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[340]

Drug(s) Affected By Forkhead box protein P1 (FOXP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[108]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[384]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[158]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[370]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[102]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]

Drug(s) Affected By SPARC-related modular calcium-binding protein 1 (SMOC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[108]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[385]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[101]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[369]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[102]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[386]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[290]

Drug(s) Affected By Homeobox protein NANOG (NANOG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[387]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[388]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[389]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[89]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[390]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[392]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[393]

Drug(s) Affected By Protein Mis18-alpha (MIS18A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[110]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[110]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[310]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[102]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]

Drug(s) Affected By Ammonium transporter Rh type C (RHCG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ammonia	DMOEVK6	Coronary artery disease	BA80	Approved	[394]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[304]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[105]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[395]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[396]
3-iodothyronamine	DM3L0F8	Discovery agent	N.A.	Investigative	[397]

Drug(s) Affected By Cytochrome P450 2A6 (CYP2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tegafur	DM31ZQM	Solid tumour/cancer	2A00-2F9Z	Approved	[398]
Methoxsalen	DME8FZ9	Cutaneous T-cell lymphoma	2B01	Approved	[399]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[400]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[401]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[290]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[402]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[403]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[404]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[405]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[406]

Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[407]
Ademetionine	DMYQDBO	Hepatic fibrosis	DB93.0	Approved	[408]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[178]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[409]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[410]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[290]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[411]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[178]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[412]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[413]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[413]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[413]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[414]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[415]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[416]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[417]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[418]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[419]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[178]

Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[420]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[18]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[421]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[422]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[423]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[424]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[420]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[425]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[426]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[427]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[428]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[429]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[430]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[431]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[432]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[433]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[434]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[435]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[436]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[437]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[438]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[439]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[439]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[440]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[441]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[442]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[443]

Drug(s) Affected By Short-chain dehydrogenase/reductase 3 (DHRS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[444]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[89]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[110]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[322]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[445]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[446]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 7 (DHRS7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[447]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[90]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[101]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[102]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[448]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[93]

Drug(s) Affected By Cytochrome P450 2A13 (CYP2A13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[401]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[409]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[409]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[449]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[105]
HELENALIN	DMMCI4H	N. A.	N. A.	Terminated	[450]
Acenaphthenol	DMT3QYZ	N. A.	N. A.	Investigative	[451]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[452]
Chrysin	DM7V2LG	Discovery agent	N.A.	Investigative	[453]
9-phenanthrol	DMJFBQ1	Discovery agent	N.A.	Investigative	[454]

Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[455]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[456]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[457]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[458]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[459]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[460]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[414]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[439]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[461]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[462]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
NADPH-dependent carbonyl reductase 1 (CBR1)	DE9JFMC	CBR1_HUMAN	Substrate	[1]
Aldo-keto reductase 1C1 (AKR1C1)	DE7P2FB	AK1C1_HUMAN	Substrate	[1]
Aldo-keto reductase 1C2 (AKR1C2)	DEOY5ZM	AK1C2_HUMAN	Substrate	[1]
Aldo-keto reductase 1C4 (AKR1C4)	DEAJN47	AK1C4_HUMAN	Substrate	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)	OTO7FJA9	DHI1_HUMAN	Biotransformations	[2]
6-phosphogluconate dehydrogenase, decarboxylating (PGD)	OTVG296F	6PGD_HUMAN	Gene/Protein Processing	[3]
Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1)	OTV57BZD	AL7A1_HUMAN	Gene/Protein Processing	[3]
Ammonium transporter Rh type C (RHCG)	OT1MTYUH	RHCG_HUMAN	Gene/Protein Processing	[3]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[4]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[5]
Argininosuccinate lyase (ASL)	OTI2NGQR	ARLY_HUMAN	Gene/Protein Processing	[3]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Gene/Protein Processing	[6]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Gene/Protein Processing	[6]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[7]

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