Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMY1AFS)

• Drug Name: LY294002 Drug Info
• Synonyms: 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; 154447-36-6; LY 294002; LY-294002; 2-morpholino-8-phenyl-4H-chromen-4-one; 2-morpholin-4-yl-8-phenyl-4H-chromen-4-one; UNII-31M2U1DVID; LY-294,002; 2-(morpholin-4-yl)-8-phenyl-4H-chromen-4-one; 31M2U1DVID; 2-MORPHOLIN-4-YL-7-PHENYL-4H-CHROMEN-4-ONE; CHEMBL98350; 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-; CHEBI:65329; 2-morpholino-8-phenyl-chromen-4-one; AK162301; 2-(morpholin-4-yl)-8-phenylchromen-4-one; LY2; 15447-36-6; IN1266; IN1268; Lys 294002; BMK1-D5; H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-(9CI); 2-(4-Morpholino)-8-phenyl-4H-1-benzopyran-4-one; 2-morpholin-4-yl-8-phenylchromen-4-one; 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl; 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-(9CI); 8-Phenyl-2-(morpholin-4-yl)-chromen-4-one; 2-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-One

Indication

Disease Entry	ICD 11	Status	REF
Neuroblastoma	2D11.2	Phase 1	[1]

• Cross-matching ID:
  PubChem CID: 3973
  ChEBI ID: CHEBI:65329
  CAS Number: CAS 154447-36-6
  TTD Drug ID: DMY1AFS

Molecule-Related Drug Atlas

Drug(s) Targeting PI3-kinase gamma (PIK3CG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BAY 80-6946	DMLOS5R	Follicular lymphoma	2A80	Approved	[12]
IPI-145	DMWA24P	Follicular lymphoma	2A80	Approved	[13]
Buparlisib	DM1WEHC	Breast cancer	2C60-2C65	Phase 3	[14]
Enzastaurin	DM5H0R9	Diffuse large B-cell lymphoma	2A81	Phase 3	[15]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[16]
GDC-0032	DMT4QHD	Breast cancer	2C60-2C65	Phase 3	[15]
PQR309	DMMCYZ8	Squamous head and neck cell carcinom	2D60.0	Phase 2	[17]
SAR245409	DMQM7IL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[18]
XL147	DMML7BE	Solid tumour/cancer	2A00-2F9Z	Phase 2	[18]
SF1126	DML10K3	Head and neck cancer	2D42	Phase 2	[19]

Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Selenium	DM25CGV	N. A.	N. A.	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[26]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]

Drug(s) Affected By Heat shock protein beta-8 (HSPB8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[35]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[36]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[39]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[40]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[41]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[42]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[43]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[44]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[45]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[46]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[47]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[45]

Drug(s) Affected By ATP-binding cassette sub-family C member 5 (ABCC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[48]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[49]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[50]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[51]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[52]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]

Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[59]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[60]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[61]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[62]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[28]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[64]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[65]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[67]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[68]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[69]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[72]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[73]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[74]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[68]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[75]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[78]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[79]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[81]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[82]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[83]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[84]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[86]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[87]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[88]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[89]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[92]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[69]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[93]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[90]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[94]
Selenium	DM25CGV	N. A.	N. A.	Approved	[95]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[96]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[97]

Drug(s) Affected By Caspase-1 (CASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[92]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[93]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[94]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[104]

Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[105]
Indomethacin	DMSC4A7	Bursitis		Approved	[106]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[108]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[111]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[112]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[113]

Drug(s) Affected By Forkhead box protein O4 (FOXO4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[116]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[36]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[117]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[119]

Drug(s) Affected By Interleukin-18 (IL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[92]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[104]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[28]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[124]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[125]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[124]

Drug(s) Affected By Beclin-1 (BECN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[126]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[132]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[133]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[134]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[137]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[139]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[140]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[33]

Drug(s) Affected By Claudin-5 (CLDN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Guanfacine extended release	DMB1CZ8	Attention deficit hyperactivity disorder	6A05.Z	Approved	[143]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[144]
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[145]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[146]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[147]
CS-600G	DM1PV4Y	N. A.	N. A.	Phase 3	[148]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[149]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[145]
JWH-133	DM1DEYU	Discovery agent	N.A.	Investigative	[150]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[151]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[152]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[92]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Selenium	DM25CGV	N. A.	N. A.	Approved	[155]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[151]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[156]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[158]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[160]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[161]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[162]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[164]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[165]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[166]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[169]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[170]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[171]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[172]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[175]

Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[177]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[178]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[179]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[182]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[183]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[184]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[185]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[186]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[189]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[190]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[191]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[192]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[193]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[194]

Drug(s) Affected By Forkhead box protein O3 (FOXO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[198]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[189]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[199]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[33]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[89]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[203]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[204]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[198]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[206]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[207]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[202]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[208]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[144]

Drug(s) Affected By L-lactate dehydrogenase A chain (LDHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[209]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[210]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[212]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[213]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[215]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[216]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[75]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[51]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[217]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[218]
Selenium	DM25CGV	N. A.	N. A.	Approved	[21]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[219]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[186]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[220]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[121]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[221]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[209]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[158]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[223]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[224]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[225]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[226]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[227]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[121]

Drug(s) Affected By Follitropin subunit beta (FSHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[228]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[229]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[230]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Cetrorelix	DMFD9Q6	Ovarian stimulation	LB45.1	Approved	[232]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[233]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[234]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[235]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[236]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]

Drug(s) Affected By Insulin-like growth factor II (IGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[237]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[239]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[191]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[241]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[244]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[245]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[246]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[247]
Fructose	DM43AN2	Vomiting	MD90	Approved	[209]
Ketoprofen	DMRKXPT	Bursitis		Approved	[209]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[248]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[249]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[250]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[251]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[252]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[253]

Drug(s) Affected By Serotransferrin (TF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[256]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[33]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[258]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[259]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[260]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[261]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[209]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[262]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[263]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[51]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[182]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[265]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[121]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[266]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[267]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[268]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[269]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[270]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[271]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[272]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[273]

Drug(s) Affected By Insulin-like growth factor I (IGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[237]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[253]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[239]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[239]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[275]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[162]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[276]

Drug(s) Affected By Eukaryotic translation initiation factor 4E (EIF4E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[277]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[278]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[279]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[280]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[282]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[165]
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[283]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[282]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]

Drug(s) Affected By Zinc finger protein GLI1 (GLI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[28]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[285]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[286]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[287]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[288]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[289]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[290]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[291]
Selenium	DM25CGV	N. A.	N. A.	Approved	[292]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[294]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[295]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[296]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[279]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[298]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[299]

Drug(s) Affected By Stromelysin-2 (MMP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[33]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[300]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[301]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[239]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[300]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[239]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[162]
Haloperidol	DM96SE0	Delirium		Approved	[302]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[303]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[304]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[169]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[305]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[306]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[305]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[307]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[308]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[309]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[310]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[311]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[312]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[67]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[313]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[69]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[314]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[90]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[315]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[316]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[317]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[318]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[209]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[319]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[320]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[249]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[321]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[322]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[323]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[324]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[302]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[325]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[325]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[212]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[326]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[203]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[327]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[328]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[329]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[330]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[212]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[331]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[191]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[332]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[333]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[334]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Selenium	DM25CGV	N. A.	N. A.	Approved	[21]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[170]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[306]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[335]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[171]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[336]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[337]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[89]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[251]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[253]
Selenium	DM25CGV	N. A.	N. A.	Approved	[292]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[338]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[307]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[178]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[339]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[340]

Drug(s) Affected By Fos-related antigen 1 (FOSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[341]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[342]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[343]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[344]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[345]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[346]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[202]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[347]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[348]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[349]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[350]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[351]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[352]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[352]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[353]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[354]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[262]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[333]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[51]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[356]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[357]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[336]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[301]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[358]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[359]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[178]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[359]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[360]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[361]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[362]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[359]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[363]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[364]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[365]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[366]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[186]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[367]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[368]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[369]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[370]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[371]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[372]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[321]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[373]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[374]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[375]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[376]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[219]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[377]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[378]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[356]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[306]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[357]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[379]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[380]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[382]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[169]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[383]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[384]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[322]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[385]
Fructose	DM43AN2	Vomiting	MD90	Approved	[386]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[387]

Drug(s) Affected By Metallothionein-3 (MT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[388]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[389]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[390]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[391]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[392]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[393]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[394]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[395]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[396]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[397]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[348]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[249]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[398]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[399]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[400]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[401]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[402]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[403]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[404]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[405]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[198]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[342]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[407]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[194]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[33]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[408]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[397]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[409]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[410]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[411]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[396]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[209]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[92]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[249]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[398]

Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[332]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[374]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[412]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[413]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[343]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[414]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[162]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[415]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[416]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[271]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[321]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[417]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[366]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[418]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[274]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[219]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[419]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[420]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[322]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[296]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[421]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[422]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[423]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[424]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[425]

Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[209]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[57]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[427]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[405]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[428]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[26]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[429]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[334]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[167]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[375]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[170]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[430]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[306]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[151]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[429]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[431]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[105]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[209]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[114]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[432]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[158]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[364]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[365]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[219]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[433]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[434]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[344]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[435]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[436]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[437]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[438]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[268]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[439]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[440]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[441]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[442]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[443]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[444]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[419]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[445]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[446]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[447]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[445]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[448]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[449]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[33]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[450]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[374]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[430]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[446]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[451]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[452]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[453]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[379]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[454]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[455]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[456]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[457]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[57]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[458]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[459]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[460]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[461]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[456]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[349]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[462]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[279]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[199]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[463]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[464]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[465]

Drug(s) Affected By Glutathione synthetase (GSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[466]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[467]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[468]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[469]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[165]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[470]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[287]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[471]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[472]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[473]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[474]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[475]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[476]
GDC0941	DM1YAK6	Breast cancer	2C60-2C65	Phase 2	[477]
GDC-0980/RG7422	DMF3MV1	Non-hodgkin lymphoma	2B33.5	Phase 2	[478]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[479]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[274]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[480]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[481]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[482]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[405]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[483]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[239]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[484]

Drug(s) Affected By Nuclear pore complex protein Nup153 (NUP153)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[431]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[485]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[486]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[487]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[488]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[165]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[302]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]

Drug(s) Affected By Glycogen synthase kinase-3 alpha (GSK3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[489]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[490]
Methamphetamine	DMPM4SK	Anxiety		Approved	[491]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[492]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[490]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[147]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[493]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[489]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[77]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[494]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[495]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[496]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[497]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[498]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[499]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[500]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[153]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[176]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[501]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[502]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[178]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[278]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[503]

Drug(s) Affected By Hexokinase-2 (HK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[504]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[212]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[505]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[506]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[507]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[337]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[75]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[508]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[509]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[510]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[510]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[511]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[512]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[513]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[514]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[515]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[320]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[516]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[169]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[517]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[518]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[519]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[520]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[521]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[369]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[522]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[523]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[524]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[415]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[33]

Drug(s) Affected By Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[525]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[525]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[525]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[526]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[165]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[527]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[528]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[529]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[255]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[92]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[530]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[303]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[516]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[531]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[509]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[532]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[533]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[92]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[534]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[534]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[535]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[536]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[266]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[199]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[537]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[92]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[321]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[538]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[539]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[540]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[541]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[542]

Drug(s) Affected By Protein kinase C zeta type (PRKCZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[543]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[544]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[545]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[546]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[105]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[547]

Drug(s) Affected By Elongation factor 1-alpha 2 (EEF1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[548]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[549]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[165]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[302]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[550]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[551]

Drug(s) Affected By Protein kinase C delta type (PRKCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[212]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[199]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[552]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[553]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[554]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[555]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[162]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[194]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[526]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[556]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[315]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[444]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[319]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[176]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[516]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[375]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[557]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[306]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[271]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[558]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[169]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[559]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[534]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[111]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[249]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[176]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[560]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[178]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[561]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[322]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[562]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[184]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[563]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[444]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[431]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[169]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[405]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[212]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[387]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[564]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[362]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[563]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[444]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[180]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[278]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[190]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[565]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[566]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[362]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[567]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[568]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[569]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[570]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[165]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[571]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[572]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[573]

Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[574]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[219]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[575]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[278]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[576]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[62]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[524]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[286]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[577]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[578]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[579]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[92]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[580]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[581]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[169]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[518]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[121]

Drug(s) Affected By Occludin (OCLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[582]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[583]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[584]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[194]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[585]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[586]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[587]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[588]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[589]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[590]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[590]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[591]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[592]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[504]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[322]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[593]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[368]

Drug(s) Affected By Programmed cell death protein 4 (PDCD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[359]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[594]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[359]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[199]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[595]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[62]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[359]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[194]

Drug(s) Affected By Inositol hexakisphosphate kinase 1 (IP6K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[147]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[596]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[444]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[92]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[597]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[598]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[405]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[599]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[192]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[407]

Drug(s) Affected By Aurora kinase B (AURKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[429]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[166]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[335]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[600]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[202]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[601]

Drug(s) Affected By Nuclear pore complex protein Nup88 (NUP88)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[485]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[165]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[602]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[545]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[105]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[572]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[147]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[364]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[603]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[342]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[604]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[605]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[606]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[435]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[607]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[151]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[608]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[182]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[199]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[609]

Drug(s) Affected By Programmed cell death 1 ligand 1 (CD274)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[610]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[611]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[171]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[612]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[487]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[202]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[613]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]

Drug(s) Affected By Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[614]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[35]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]

Drug(s) Affected By Axin-2 (AXIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[191]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[615]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[616]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[9]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[617]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[618]

Drug(s) Affected By Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[593]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[279]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[522]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[194]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[165]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[35]

Drug(s) Affected By Methylsterol monooxygenase 1 (MSMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[593]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[405]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[279]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[194]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[202]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[271]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[431]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[619]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[121]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[620]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[212]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[621]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[622]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[194]

Drug(s) Affected By Galectin-3 (LGALS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[457]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[623]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[191]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[194]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[623]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[286]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PI3-kinase gamma (PIK3CG)	TTHBTOP	PK3CG_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[3]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Gene/Protein Processing	[4]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[5]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[6]
ATP-binding cassette sub-family C member 5 (ABCC5)	OT34G4US	MRP5_HUMAN	Gene/Protein Processing	[4]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[7]
Aurora kinase B (AURKB)	OTIY4VHU	AURKB_HUMAN	Gene/Protein Processing	[8]
Axin-2 (AXIN2)	OTRMGQNU	AXIN2_HUMAN	Gene/Protein Processing	[9]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Gene/Protein Processing	[10]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Gene/Protein Processing	[11]

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