Details of the Drug Combination

General Information of Drug Combination (ID: DC0T79H)

Drug Combination Name
Tamibarotene Venetoclax
Indication
Disease Entry Status REF
Acute Myeloid Leukemia Phase 2 [1]
Component Drugs Tamibarotene   DM3G74J Venetoclax   DM8I94Y
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Tamibarotene
Disease Entry ICD 11 Status REF
T-cell leukaemia 2A90 Phase 3 [2]
Alzheimer disease 8A20 Phase 2/3 [3]
Tamibarotene Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Retinoic acid receptor beta (RARB) TTISP28 RARB_HUMAN Modulator [8]
Retinoic acid receptor alpha (RARA) TTW38KT RARA_HUMAN Modulator [8]
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Tamibarotene Interacts with 511 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Retinoic acid receptor alpha (RARA) OT192V9V RARA_HUMAN Decreases Response To Substance [9]
Protein-glutamine gamma-glutamyltransferase 2 (TGM2) OT6MFOWF TGM2_HUMAN Increases Activity [10]
Golgin subfamily A member 8A (GOLGA8A) OTSNE9EQ GOG8A_HUMAN Decreases Expression [5]
TANK-binding kinase 1-binding protein 1 (TBKBP1) OTXTU37H TBKB1_HUMAN Decreases Expression [5]
Alternative prion protein (PRNP) OTE85L1Q APRIO_HUMAN Affects Expression [5]
Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) OTFBFPV4 ADAS_HUMAN Affects Expression [5]
Kinesin-like protein KIF2A (KIF2A) OT2WQ6QD KIF2A_HUMAN Decreases Expression [5]
Galectin-9 (LGALS9) OT7MF91K LEG9_HUMAN Increases Expression [5]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD) OTOMP6TH PK3CD_HUMAN Increases Expression [5]
Pyruvate dehydrogenase protein X component, mitochondrial (PDHX) OTG7O271 ODPX_HUMAN Affects Expression [5]
Importin-5 (IPO5) OTAK40ED IPO5_HUMAN Affects Expression [5]
Serine/threonine-protein kinase PLK4 (PLK4) OTV8KZDZ PLK4_HUMAN Decreases Expression [5]
Leukocyte-specific transcript 1 protein (LST1) OTUVG424 LST1_HUMAN Increases Expression [5]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Affects Expression [5]
Class E basic helix-loop-helix protein 40 (BHLHE40) OTITX14U BHE40_HUMAN Affects Expression [5]
Aquaporin-7 (AQP7) OTSOSZEE AQP7_HUMAN Affects Expression [5]
Nuclear envelope integral membrane protein 1 (NEMP1) OTWN3S47 NEMP1_HUMAN Decreases Expression [5]
Thymosin beta-4, Y-chromosomal (TMSB4Y) OT1BMJ6B TYB4Y_HUMAN Affects Expression [5]
Segment polarity protein dishevelled homolog DVL-1 (DVL1) OTD67RF1 DVL1_HUMAN Decreases Expression [5]
Torsin-1B (TOR1B) OTNEL2PZ TOR1B_HUMAN Increases Expression [5]
Syntaxin-16 (STX16) OTM7TAOE STX16_HUMAN Affects Expression [5]
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF1) OTFK8KDP NHRF1_HUMAN Increases Expression [5]
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) OTPGHZB9 IFIT3_HUMAN Increases Expression [5]
Antizyme inhibitor 1 (AZIN1) OTX5W77I AZIN1_HUMAN Affects Expression [5]
Protein transport protein Sec16A (SEC16A) OTFNQ1ZU SC16A_HUMAN Decreases Expression [5]
FYN-binding protein 1 (FYB1) OT6345CH FYB1_HUMAN Affects Expression [5]
Secretory carrier-associated membrane protein 1 (SCAMP1) OTFS4IKJ SCAM1_HUMAN Affects Expression [5]
Phospholipid scramblase 1 (PLSCR1) OTGY9B5T PLS1_HUMAN Increases Expression [5]
Axin-1 (AXIN1) OTRGZGZ5 AXIN1_HUMAN Increases Expression [5]
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) OT1Z1ZXE OGT1_HUMAN Decreases Expression [5]
Monocarboxylate transporter 4 (SLC16A3) OTDIXEXY MOT4_HUMAN Increases Expression [5]
Regulator of G-protein signaling 16 (RGS16) OTBKZASI RGS16_HUMAN Decreases Expression [5]
N-glycosylase/DNA lyase (OGG1) OTJ97TF3 OGG1_HUMAN Increases Expression [5]
mRNA cap guanine-N7 methyltransferase (RNMT) OTIC02RT MCES_HUMAN Affects Expression [5]
Cytoplasmic dynein 1 light intermediate chain 2 (DYNC1LI2) OTR7WJES DC1L2_HUMAN Decreases Expression [5]
CBP80/20-dependent translation initiation factor (CTIF) OT7DU7WN CTIF_HUMAN Decreases Expression [5]
Eukaryotic translation elongation factor 1 epsilon-1 (EEF1E1) OTRA6XOB MCA3_HUMAN Decreases Expression [5]
RNA-binding protein Musashi homolog 1 (MSI1) OTAN4FSC MSI1H_HUMAN Affects Expression [5]
Trans-Golgi network integral membrane protein 2 (TGOLN2) OTM647IV TGON2_HUMAN Affects Expression [5]
Protein-glutamine gamma-glutamyltransferase 5 (TGM5) OTHI37BJ TGM5_HUMAN Increases Expression [5]
Tumor necrosis factor ligand superfamily member 14 (TNFSF14) OT5QRF09 TNF14_HUMAN Increases Expression [5]
Protein sprouty homolog 2 (SPRY2) OTH0CRCZ SPY2_HUMAN Increases Expression [5]
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial (GATC) OTBLY3PP GATC_HUMAN Affects Expression [5]
Cleavage and polyadenylation specificity factor subunit 5 (NUDT21) OTZHKWAR CPSF5_HUMAN Affects Expression [5]
Cyclic AMP-responsive element-binding protein 3 (CREB3) OT9617UO CREB3_HUMAN Increases Expression [5]
Docking protein 2 (DOK2) OTIJ38UF DOK2_HUMAN Increases Expression [5]
Protein O-GlcNAcase (OGA) OT7ZBWT1 OGA_HUMAN Decreases Expression [5]
Exocyst complex component 3 (EXOC3) OT8N3306 EXOC3_HUMAN Affects Expression [5]
Monocarboxylate transporter 2 (SLC16A7) OT7OI36B MOT2_HUMAN Affects Expression [5]
DNA polymerase zeta catalytic subunit (REV3L) OT0OP8EJ REV3L_HUMAN Decreases Expression [5]
Coiled-coil domain-containing protein 22 (CCDC22) OT1A1ZXH CCD22_HUMAN Affects Expression [5]
Ankyrin repeat domain-containing protein 17 (ANKRD17) OTQ3DYEP ANR17_HUMAN Decreases Expression [5]
Pre-mRNA-processing factor 40 homolog A (PRPF40A) OT6EXJZN PR40A_HUMAN Affects Expression [5]
Histone deacetylase complex subunit SAP30 (SAP30) OT73OLML SAP30_HUMAN Decreases Expression [5]
Serine/arginine-rich splicing factor 10 (SRSF10) OTY6IJ11 SRS10_HUMAN Decreases Expression [5]
Protein CREG1 (CREG1) OTRHJ8HK CREG1_HUMAN Increases Expression [5]
U5 small nuclear ribonucleoprotein 200 kDa helicase (SNRNP200) OTSAU864 U520_HUMAN Decreases Expression [5]
Short-chain dehydrogenase/reductase 3 (DHRS3) OTSK1DTP DHRS3_HUMAN Increases Expression [5]
Flotillin-1 (FLOT1) OT0JPPJZ FLOT1_HUMAN Increases Expression [5]
Triple functional domain protein (TRIO) OT71X1AK TRIO_HUMAN Affects Expression [5]
Protein transport protein Sec31A (SEC31A) OT2U42AC SC31A_HUMAN Decreases Expression [5]
Calmodulin-binding transcription activator 2 (CAMTA2) OT6PIWF4 CMTA2_HUMAN Increases Expression [5]
Amyloid-beta A4 precursor protein-binding family B member 3 (APBB3) OTNUTR0N APBB3_HUMAN Affects Expression [5]
Adenosine deaminase (ADA) OTOX2872 ADA_HUMAN Increases Expression [5]
2'-5'-oligoadenylate synthase 1 (OAS1) OT8ZLOCY OAS1_HUMAN Affects Expression [5]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Increases Expression [5]
Cystatin-C (CST3) OTNZ6AO4 CYTC_HUMAN Increases Expression [5]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [5]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Expression [5]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [5]
Tissue alpha-L-fucosidase (FUCA1) OTW71IK4 FUCO_HUMAN Increases Expression [5]
Metallothionein-1A (MT1A) OTKBH52X MT1A_HUMAN Increases Expression [5]
Cytochrome b-245 heavy chain (CYBB) OTGSG868 CY24B_HUMAN Increases Expression [5]
Protein S100-A8 (S100A8) OTVMOB3F S10A8_HUMAN Increases Expression [5]
Plasminogen activator inhibitor 2 (SERPINB2) OT72QLZB PAI2_HUMAN Decreases Expression [5]
Ubiquitin-like protein ISG15 (ISG15) OT53QQ7N ISG15_HUMAN Affects Expression [5]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Increases Expression [5]
Protein kinase C beta type (PRKCB) OTYQ0656 KPCB_HUMAN Increases Expression [5]
Tyrosine-protein kinase Lck (LCK) OT883FG9 LCK_HUMAN Increases Expression [5]
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Decreases Expression [5]
Gelsolin (GSN) OT4KS2UU GELS_HUMAN Increases Expression [5]
Protein S100-A9 (S100A9) OTOARHCS S10A9_HUMAN Increases Expression [5]
Glutathione peroxidase 1 (GPX1) OTE2O72Q GPX1_HUMAN Affects Expression [5]
Tyrosine-protein kinase Fes/Fps (FES) OTSE0XIF FES_HUMAN Affects Expression [5]
Cathepsin D (CTSD) OTQZ36F3 CATD_HUMAN Increases Expression [5]
Annexin A2 (ANXA2) OTFNS0CC ANXA2_HUMAN Decreases Expression [5]
Galactose-1-phosphate uridylyltransferase (GALT) OTCATU66 GALT_HUMAN Increases Expression [5]
Tyrosine-protein kinase Lyn (LYN) OTP686K2 LYN_HUMAN Increases Expression [5]
Heat shock protein HSP 90-beta (HSP90AB1) OTR69EG7 HS90B_HUMAN Affects Expression [5]
Extracellular superoxide dismutase (SOD3) OTIOZQAB SODE_HUMAN Decreases Expression [5]
Pleckstrin (PLEK) OTB73XXA PLEK_HUMAN Increases Expression [5]
Tyrosine-protein kinase HCK (HCK) OTRL6OSI HCK_HUMAN Increases Expression [5]
Galectin-1 (LGALS1) OT8LDFWR LEG1_HUMAN Increases Expression [5]
Fructose-1,6-bisphosphatase 1 (FBP1) OTQBANEP F16P1_HUMAN Increases Expression [5]
Glutathione S-transferase Mu 1 (GSTM1) OTSBF2MO GSTM1_HUMAN Increases Expression [5]
Clathrin light chain B (CLTB) OTPW9VRE CLCB_HUMAN Increases Expression [5]
Tyrosine-protein kinase Fgr (FGR) OTCUYU9F FGR_HUMAN Increases Expression [5]
Adenosine receptor A3 (ADORA3) OTHO1BLK AA3R_HUMAN Affects Expression [5]
Choriogonadotropin subunit beta 3 (CGB3) OTVM2SU3 CGB3_HUMAN Decreases Expression [5]
Transcriptional activator Myb (MYB) OTJH64IV MYB_HUMAN Affects Expression [5]
HLA class I histocompatibility antigen, C alpha chain (HLA-C) OTV38BUJ HLAC_HUMAN Increases Expression [5]
Osteopontin (SPP1) OTJGC23Y OSTP_HUMAN Increases Expression [5]
Receptor-type tyrosine-protein phosphatase F (PTPRF) OTH5KF2D PTPRF_HUMAN Decreases Expression [5]
Interferon regulatory factor 1 (IRF1) OT43DI6J IRF1_HUMAN Increases Expression [5]
Laminin subunit gamma-1 (LAMC1) OTIG527N LAMC1_HUMAN Decreases Expression [5]
Integrin alpha-M (ITGAM) OTAG6HWU ITAM_HUMAN Increases Expression [5]
Serine/threonine-protein kinase pim-1 (PIM1) OTWEKXTU PIM1_HUMAN Increases Expression [5]
Fibroblast growth factor receptor 1 (FGFR1) OT4GLCXW FGFR1_HUMAN Decreases Expression [5]
DNA topoisomerase 1 (TOP1) OT51O0CF TOP1_HUMAN Decreases Expression [5]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Affects Expression [5]
Eosinophil peroxidase (EPX) OTFNDFOK PERE_HUMAN Decreases Expression [5]
Ornithine decarboxylase (ODC1) OTNDAGRR DCOR_HUMAN Decreases Expression [5]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Affects Expression [5]
Nucleoprotein TPR (TPR) OTUBBA4W TPR_HUMAN Decreases Expression [5]
High affinity immunoglobulin gamma Fc receptor I (FCGR1A) OTOBCS2O FCGR1_HUMAN Affects Expression [5]
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1) OTQY6ZSF HEM1_HUMAN Increases Expression [5]
C-C motif chemokine 4 (CCL4) OT6B8P25 CCL4_HUMAN Increases Expression [5]
Cytochrome b-245 light chain (CYBA) OT16N9ZO CY24A_HUMAN Increases Expression [5]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Increases Expression [5]
Integrin alpha-4 (ITGA4) OTSCAL0V ITA4_HUMAN Affects Expression [5]
Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3) OTM8EG6H AT1A3_HUMAN Affects Expression [5]
HLA class I histocompatibility antigen, alpha chain E (HLA-E) OTX1CTFB HLAE_HUMAN Increases Expression [5]
Collagen alpha-2(XI) chain (COL11A2) OT3BQUBH COBA2_HUMAN Affects Expression [5]
L-selectin (SELL) OT6RAJZR LYAM1_HUMAN Increases Expression [5]
Neutrophil cytosol factor 1 (NCF1) OTMHT3G6 NCF1_HUMAN Increases Expression [5]
Endoplasmin (HSP90B1) OT02XLBR ENPL_HUMAN Decreases Expression [5]
15-hydroxyprostaglandin dehydrogenase (HPGD) OTYZI6JB PGDH_HUMAN Affects Expression [5]
Small ribosomal subunit protein uS5 (RPS2) OTSMTZVB RS2_HUMAN Increases Expression [5]
Aggrecan core protein (ACAN) OTUOCW8K PGCA_HUMAN Affects Expression [5]
Cyclic AMP-responsive element-binding protein 1 (CREB1) OT1MDLA1 CREB1_HUMAN Affects Expression [5]
SH2/SH3 adapter protein NCK1 (NCK1) OTKYZ4OP NCK1_HUMAN Affects Expression [5]
Histone H1.3 (H1-3) OTT7VPRB H13_HUMAN Affects Expression [5]
NADPH--cytochrome P450 reductase (POR) OTVIDOCH NCPR_HUMAN Increases Expression [5]
Rho-related GTP-binding protein RhoQ (RHOQ) OTUBTU57 RHOQ_HUMAN Affects Expression [5]
Bactericidal permeability-increasing protein (BPI) OTNN9LJ5 BPI_HUMAN Increases Expression [5]
Sphingomyelin phosphodiesterase (SMPD1) OTZSMA54 ASM_HUMAN Increases Expression [5]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Increases Expression [5]
HLA class I histocompatibility antigen, alpha chain G (HLA-G) OTMLK1KN HLAG_HUMAN Increases Expression [5]
S-adenosylmethionine decarboxylase proenzyme (AMD1) OTKAGZY3 DCAM_HUMAN Decreases Expression [5]
Insulin-like growth factor-binding protein 2 (IGFBP2) OTG1P60E IBP2_HUMAN Affects Expression [5]
Protein SON (SON) OT9VWV18 SON_HUMAN Affects Expression [5]
Regulator of chromosome condensation (RCC1) OT25AGMB RCC1_HUMAN Decreases Expression [5]
Leukocyte surface antigen CD53 (CD53) OT9U5OXJ CD53_HUMAN Increases Expression [5]
Glutathione hydrolase 1 proenzyme (GGT1) OTYDA1Z7 GGT1_HUMAN Increases Expression [5]
Plasma membrane calcium-transporting ATPase 1 (ATP2B1) OT5MXG9W AT2B1_HUMAN Affects Expression [5]
Serine protease inhibitor Kazal-type 2 (SPINK2) OTSFBT0G ISK2_HUMAN Decreases Expression [5]
Azurocidin (AZU1) OTHXU264 CAP7_HUMAN Increases Expression [5]
B-cell receptor CD22 (CD22) OTXDJR9T CD22_HUMAN Affects Expression [5]
Transcription factor BTF3 (BTF3) OT5ZZFJL BTF3_HUMAN Affects Expression [5]
Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) OT0DH40W AL5AP_HUMAN Increases Expression [5]
Ras-related protein Rab-4A (RAB4A) OT7BL9WW RAB4A_HUMAN Decreases Expression [5]
Ras-related protein Rab-5A (RAB5A) OTFR2KM4 RAB5A_HUMAN Affects Expression [5]
Ras-related protein Rab-6A (RAB6A) OTLS86J5 RAB6A_HUMAN Affects Expression [5]
Interferon-induced GTP-binding protein Mx2 (MX2) OT05NF37 MX2_HUMAN Affects Expression [5]
Lamin-B1 (LMNB1) OT100T3P LMNB1_HUMAN Affects Expression [5]
Endothelin-2 (EDN2) OTQ7RCPI EDN2_HUMAN Increases Expression [5]
Cysteine and glycine-rich protein 1 (CSRP1) OTUS7RM2 CSRP1_HUMAN Affects Expression [5]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Increases Expression [5]
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) OTGYVSGU PIMT_HUMAN Affects Expression [5]
Alpha-(1,3)-fucosyltransferase 4 (FUT4) OTIBXRTL FUT4_HUMAN Increases Expression [5]
Small proline-rich protein 2D (SPRR2D) OT47THNK SPR2D_HUMAN Affects Expression [5]
cAMP-dependent protein kinase catalytic subunit beta (PRKACB) OT6RMDCE KAPCB_HUMAN Decreases Expression [5]
Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5) OTZNYEKF GTR5_HUMAN Increases Expression [5]
Splicing factor, proline- and glutamine-rich (SFPQ) OTLCIAPJ SFPQ_HUMAN Decreases Expression [5]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Affects Expression [5]
Tyrosine-protein kinase JAK1 (JAK1) OT0X3D17 JAK1_HUMAN Affects Expression [5]
Eukaryotic translation initiation factor 4B (EIF4B) OTE8TXA8 IF4B_HUMAN Decreases Expression [5]
Endothelial transcription factor GATA-2 (GATA2) OTBP2QQ2 GATA2_HUMAN Decreases Expression [5]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Increases Expression [5]
COUP transcription factor 2 (NR2F2) OTJFS67N COT2_HUMAN Decreases Expression [5]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Decreases Expression [5]
Adenomatous polyposis coli protein (APC) OTKV0TIK APC_HUMAN Decreases Expression [5]
Nuclear transcription factor Y subunit beta (NFYB) OTXSE7KW NFYB_HUMAN Decreases Expression [5]
Metallothionein-3 (MT3) OTVCZ7HI MT3_HUMAN Affects Expression [5]
Integrin beta-7 (ITGB7) OT33UUKU ITB7_HUMAN Increases Expression [5]
Tyrosine-protein phosphatase non-receptor type 3 (PTPN3) OTSLZBVY PTN3_HUMAN Affects Expression [5]
Adenylate kinase 4, mitochondrial (AK4) OTA0T02Q KAD4_HUMAN Decreases Expression [5]
Proteasome subunit beta type-9 (PSMB9) OTFV57T8 PSB9_HUMAN Increases Expression [5]
Grancalcin (GCA) OTAJ7ZHG GRAN_HUMAN Increases Expression [5]
Progranulin (GRN) OTXXSJ53 GRN_HUMAN Increases Expression [5]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) OTG0TTX7 CD38_HUMAN Increases Expression [5]
2'-5'-oligoadenylate synthase 2 (OAS2) OT64CCTM OAS2_HUMAN Increases Expression [5]
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B) OTFIHQGD 2AAB_HUMAN Affects Expression [5]
High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) OTBZBL9Y FCERG_HUMAN Increases Expression [5]
M-phase inducer phosphatase 1 (CDC25A) OTSLKKCO MPIP1_HUMAN Decreases Expression [5]
Leukocyte elastase inhibitor (SERPINB1) OT5RDUFO ILEU_HUMAN Increases Expression [5]
Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) OTXW9TE2 AL1B1_HUMAN Affects Expression [5]
Coronin-1A (CORO1A) OTVAZOHC COR1A_HUMAN Increases Expression [5]
S-adenosylmethionine synthase isoform type-2 (MAT2A) OTFJMIQR METK2_HUMAN Decreases Expression [5]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) OTOB6J6R RIR2_HUMAN Affects Expression [5]
Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) OTCJD51H FCG2B_HUMAN Affects Expression [5]
C-C chemokine receptor type 1 (CCR1) OT4FC783 CCR1_HUMAN Increases Expression [5]
C-X-C chemokine receptor type 5 (CXCR5) OTVBCQZX CXCR5_HUMAN Increases Expression [5]
4-hydroxyphenylpyruvate dioxygenase (HPD) OTDKD5EH HPPD_HUMAN Increases Expression [5]
Intercellular adhesion molecule 3 (ICAM3) OTTZ5A5D ICAM3_HUMAN Increases Expression [5]
Lymphocyte-specific protein 1 (LSP1) OTSPSIFO LSP1_HUMAN Increases Expression [5]
Fibrillin-2 (FBN2) OT3KYJQL FBN2_HUMAN Decreases Expression [5]
Glutaredoxin-1 (GLRX) OT0QHTAR GLRX1_HUMAN Increases Expression [5]
Choline kinase alpha (CHKA) OT7FVO3Z CHKA_HUMAN Decreases Expression [5]
Serine/threonine-protein kinase receptor R3 (ACVRL1) OT1HQR88 ACVL1_HUMAN Decreases Expression [5]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [5]
V-type proton ATPase catalytic subunit A (ATP6V1A) OTYZ2S9E VATA_HUMAN Affects Expression [5]
Macrophage-capping protein (CAPG) OTJ86KI6 CAPG_HUMAN Increases Expression [5]
Replication factor C subunit 5 (RFC5) OTAD79RT RFC5_HUMAN Affects Expression [5]
Cyclin-F (CCNF) OTJFVU43 CCNF_HUMAN Decreases Expression [5]
Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) OTARRES9 IF2G_HUMAN Affects Expression [5]
Protein kinase C iota type (PRKCI) OTKBAVT3 KPCI_HUMAN Decreases Expression [5]
Enoyl-CoA delta isomerase 1, mitochondrial (ECI1) OTRQTK84 ECI1_HUMAN Affects Expression [5]
Lamina-associated polypeptide 2, isoform alpha (TMPO) OTL68EL4 LAP2A_HUMAN Affects Expression [5]
Signal transducer and activator of transcription 1-alpha/beta (STAT1) OTLMBUZ6 STAT1_HUMAN Increases Expression [5]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB) OTO8JQJA PK3CB_HUMAN Affects Expression [5]
Translocon-associated protein subunit alpha (SSR1) OTQ6GDL2 SSRA_HUMAN Affects Expression [5]
Transcriptional regulator ATRX (ATRX) OT77RSQW ATRX_HUMAN Decreases Expression [5]
Radiation-inducible immediate-early gene IEX-1 (IER3) OTZJI5FZ IEX1_HUMAN Increases Expression [5]
Serpin B10 (SERPINB10) OT5ZM0X6 SPB10_HUMAN Decreases Expression [5]
Excitatory amino acid transporter 4 (SLC1A6) OTRSPH8U EAA4_HUMAN Decreases Expression [5]
Phosphatidylinositol transfer protein beta isoform (PITPNB) OTNM6T78 PIPNB_HUMAN Affects Expression [5]
Cyclin-dependent kinase 8 (CDK8) OTMC3CWX CDK8_HUMAN Affects Expression [5]
Glutamate dehydrogenase 2, mitochondrial (GLUD2) OTF3GGYY DHE4_HUMAN Affects Expression [5]
Homeobox even-skipped homolog protein 1 (EVX1) OT4A84VD EVX1_HUMAN Decreases Expression [5]
CCAAT/enhancer-binding protein delta (CEBPD) OTNBIPMY CEBPD_HUMAN Increases Expression [5]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Affects Expression [5]
Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ) OTOODWTU GNAQ_HUMAN Affects Expression [5]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 (GNG4) OTOXNDI9 GBG4_HUMAN Decreases Expression [5]
Sulfate transporter (SLC26A2) OTJNHNTO S26A2_HUMAN Affects Expression [5]
Serpin B8 (SERPINB8) OT5T4Y5R SPB8_HUMAN Affects Expression [5]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Expression [5]
Lipopolysaccharide-responsive and beige-like anchor protein (LRBA) OTOUZN9G LRBA_HUMAN Affects Expression [5]
Poly(A) polymerase alpha (PAPOLA) OTPHD65D PAPOA_HUMAN Affects Expression [5]
Ras-related protein Rab-5C (RAB5C) OTQE5QQ2 RAB5C_HUMAN Increases Expression [5]
Breast cancer type 2 susceptibility protein (BRCA2) OTF1XSV1 BRCA2_HUMAN Decreases Expression [5]
Signal transducer and activator of transcription 5B (STAT5B) OTZVPEBT STA5B_HUMAN Decreases Expression [5]
Chloride channel protein ClC-Ka (CLCNKA) OT7Q0RI9 CLCKA_HUMAN Decreases Expression [5]
Ribosomal protein S6 kinase alpha-3 (RPS6KA3) OTYJNNMD KS6A3_HUMAN Decreases Expression [5]
Cyclin-G1 (CCNG1) OT17IA9L CCNG1_HUMAN Affects Expression [5]
6-phosphogluconate dehydrogenase, decarboxylating (PGD) OTVG296F 6PGD_HUMAN Increases Expression [5]
Nuclear cap-binding protein subunit 2 (NCBP2) OTQNZTE4 NCBP2_HUMAN Decreases Expression [5]
DNA mismatch repair protein Msh6 (MSH6) OT46FP09 MSH6_HUMAN Decreases Expression [5]
Hexokinase-3 (HK3) OTZKONGB HXK3_HUMAN Increases Expression [5]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Increases Expression [5]
CCAAT/enhancer-binding protein gamma (CEBPG) OTGNAX3H CEBPG_HUMAN Decreases Expression [5]
Geranylgeranyl transferase type-2 subunit beta (RABGGTB) OTZ25I2W PGTB2_HUMAN Decreases Expression [5]
E3 ubiquitin-protein ligase TTC3 (TTC3) OTTR9WUC TTC3_HUMAN Decreases Expression [5]
Monocarboxylate transporter 1 (SLC16A1) OTW1UTZ7 MOT1_HUMAN Affects Expression [5]
Protein HIRA (HIRA) OTON40EJ HIRA_HUMAN Affects Expression [5]
Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1) OTYHXLWZ BCAT1_HUMAN Affects Expression [5]
Allograft inflammatory factor 1 (AIF1) OTGES18F AIF1_HUMAN Increases Expression [5]
Bax inhibitor 1 (TMBIM6) OTP7PI9L BI1_HUMAN Affects Expression [5]
Microfibril-associated glycoprotein 3 (MFAP3) OTFAU0YL MFAP3_HUMAN Affects Expression [5]
Nucleosome assembly protein 1-like 1 (NAP1L1) OTI7WBZV NP1L1_HUMAN Decreases Expression [5]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Expression [5]
Protein arginine N-methyltransferase 2 (PRMT2) OT63JZCI ANM2_HUMAN Increases Expression [5]
AP-1 complex subunit sigma-2 (AP1S2) OTZHJFYI AP1S2_HUMAN Increases Expression [5]
ADP-ribosylation factor-like protein 4C (ARL4C) OTQ3QNNU ARL4C_HUMAN Decreases Expression [5]
Ribose-phosphate pyrophosphokinase 1 (PRPS1) OTN3A6CN PRPS1_HUMAN Affects Expression [5]
NPC intracellular cholesterol transporter 2 (NPC2) OTE9UEJC NPC2_HUMAN Increases Expression [5]
Nuclear transport factor 2 (NUTF2) OT8VA2ZF NTF2_HUMAN Affects Expression [5]
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB) OTYFTYFR PP1B_HUMAN Decreases Expression [5]
ADP-ribosylation factor 6 (ARF6) OTVV7KJO ARF6_HUMAN Affects Expression [5]
Histone H4 (H4C1) OTB71W46 H4_HUMAN Affects Expression [5]
Ras-related protein Rab-1A (RAB1A) OTKPHRD0 RAB1A_HUMAN Affects Expression [5]
Elongation factor 1-alpha 1 (EEF1A1) OT00THXS EF1A1_HUMAN Increases Expression [5]
Glutathione S-transferase omega-1 (GSTO1) OTUJ93MN GSTO1_HUMAN Increases Expression [5]
DNA-dependent protein kinase catalytic subunit (PRKDC) OTJVS4EG PRKDC_HUMAN Decreases Expression [5]
Protein BTG2 (BTG2) OTZF6K1H BTG2_HUMAN Increases Expression [5]
Interferon-induced 35 kDa protein (IFI35) OTV9RZ53 IN35_HUMAN Increases Expression [5]
Serine/arginine-rich splicing factor 3 (SRSF3) OTOFT707 SRSF3_HUMAN Affects Expression [5]
Rho GTPase-activating protein 4 (ARHGAP4) OTXV053R RHG04_HUMAN Increases Expression [5]
Forkhead box protein O4 (FOXO4) OT90X9LN FOXO4_HUMAN Increases Expression [5]
Interferon regulatory factor 9 (IRF9) OTK4MYQJ IRF9_HUMAN Increases Expression [5]
Runt-related transcription factor 1 (RUNX1) OTU7J84H RUNX1_HUMAN Affects Expression [5]
N-acetylgalactosamine kinase (GALK2) OTHR35JF GALK2_HUMAN Decreases Expression [5]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Affects Expression [5]
Transgelin (TAGLN) OTAEZ0KP TAGL_HUMAN Affects Expression [5]
DNA topoisomerase 2-beta (TOP2B) OTDHKQZ8 TOP2B_HUMAN Affects Expression [5]
Dystonin (DST) OTHZBM4X DYST_HUMAN Decreases Expression [5]
Tumor necrosis factor alpha-induced protein 2 (TNFAIP2) OTRZH80H TNAP2_HUMAN Increases Expression [5]
Antigen peptide transporter 1 (TAP1) OTJL27PW TAP1_HUMAN Increases Expression [5]
Antigen peptide transporter 2 (TAP2) OTWSYFI7 TAP2_HUMAN Increases Expression [5]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Affects Expression [5]
Protein kinase C delta type (PRKCD) OTSEH90E KPCD_HUMAN Increases Expression [5]
Amidophosphoribosyltransferase (PPAT) OTXK12ZB PUR1_HUMAN Decreases Expression [5]
Glutamine--fructose-6-phosphate aminotransferase 1 (GFPT1) OTQBDO45 GFPT1_HUMAN Affects Expression [5]
Early growth response protein 3 (EGR3) OTGPJIRA EGR3_HUMAN Increases Expression [5]
Early activation antigen CD69 (CD69) OTGJHSVP CD69_HUMAN Affects Expression [5]
Protocadherin-1 (PCDH1) OT7KDEL3 PCDH1_HUMAN Affects Expression [5]
Interleukin-10 receptor subunit beta (IL10RB) OT5AN6ZR I10R2_HUMAN Increases Expression [5]
CMRF35-like molecule 6 (CD300C) OT4BSR7D CLM6_HUMAN Increases Expression [5]
Histone-binding protein RBBP4 (RBBP4) OTG3BT3M RBBP4_HUMAN Affects Expression [5]
Neuroblast differentiation-associated protein AHNAK (AHNAK) OT6KH1WG AHNK_HUMAN Decreases Expression [5]
Bone marrow stromal antigen 2 (BST2) OTU4LCJV BST2_HUMAN Affects Expression [5]
Tastin (TROAP) OTC8CE0R TROAP_HUMAN Decreases Expression [5]
Nucleosome-remodeling factor subunit BPTF (BPTF) OTD1RZAD BPTF_HUMAN Affects Expression [5]
Interleukin enhancer-binding factor 3 (ILF3) OTKMZ5K5 ILF3_HUMAN Decreases Expression [5]
Transcription initiation factor TFIID subunit 10 (TAF10) OTEPTEZ3 TAF10_HUMAN Increases Expression [5]
PR domain zinc finger protein 2 (PRDM2) OT8L7CGX PRDM2_HUMAN Affects Expression [5]
Lymphocyte cytosolic protein 2 (LCP2) OT57KE22 LCP2_HUMAN Increases Expression [5]
Krueppel-like factor 10 (KLF10) OT4F4UGS KLF10_HUMAN Decreases Expression [5]
Liprin-alpha-1 (PPFIA1) OTYYFA9C LIPA1_HUMAN Decreases Expression [5]
Serine/threonine-protein kinase PAK 1 (PAK1) OT17LZNZ PAK1_HUMAN Increases Expression [5]
Serine/threonine-protein kinase PAK 2 (PAK2) OTLUNCIH PAK2_HUMAN Affects Expression [5]
Chromobox protein homolog 3 (CBX3) OTOP9RLD CBX3_HUMAN Affects Expression [5]
DNA excision repair protein ERCC-8 (ERCC8) OT0T4WKI ERCC8_HUMAN Decreases Expression [5]
Src-like-adapter (SLA) OTV17DY2 SLAP1_HUMAN Increases Expression [5]
Voltage-gated potassium channel subunit beta-2 (KCNAB2) OTH115IE KCAB2_HUMAN Affects Expression [5]
S-phase kinase-associated protein 2 (SKP2) OTD5B41X SKP2_HUMAN Decreases Expression [5]
Metastasis-associated protein MTA1 (MTA1) OTBHW3S9 MTA1_HUMAN Decreases Expression [5]
Origin recognition complex subunit 2 (ORC2) OTLIYP8M ORC2_HUMAN Decreases Expression [5]
Integrin-linked protein kinase (ILK) OTYG2FD1 ILK_HUMAN Increases Expression [5]
DNA-binding protein Ikaros (IKZF1) OTCW1FKL IKZF1_HUMAN Affects Expression [5]
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5) OT404F9K FKBP5_HUMAN Decreases Expression [5]
Mothers against decapentaplegic homolog 4 (SMAD4) OTWQWCKG SMAD4_HUMAN Decreases Expression [5]
V-type proton ATPase 116 kDa subunit a 3 (TCIRG1) OTU1AIEW VPP3_HUMAN Increases Expression [5]
Mediator of RNA polymerase II transcription subunit 21 (MED21) OT0XWLMK MED21_HUMAN Affects Expression [5]
Cullin-1 (CUL1) OTXPE1UZ CUL1_HUMAN Decreases Expression [5]
Ras-related protein Rab-31 (RAB31) OTMLXQZ0 RAB31_HUMAN Increases Expression [5]
Bleomycin hydrolase (BLMH) OT2QPWQJ BLMH_HUMAN Decreases Expression [5]
Krueppel-like factor 9 (KLF9) OTBFEJRQ KLF9_HUMAN Decreases Expression [5]
Runt-related transcription factor 2 (RUNX2) OT97RQQM RUNX2_HUMAN Decreases Expression [5]
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1) OTRN55RE KCC1A_HUMAN Increases Expression [5]
Eukaryotic translation initiation factor 3 subunit A (EIF3A) OTFABY9G EIF3A_HUMAN Decreases Expression [5]
Transcription factor Dp-1 (TFDP1) OT6RZ7VT TFDP1_HUMAN Affects Expression [5]
Transcription factor Dp-2 (TFDP2) OTKQFX5H TFDP2_HUMAN Decreases Expression [5]
Eukaryotic initiation factor 4A-II (EIF4A2) OT08H03R IF4A2_HUMAN Decreases Expression [5]
Adhesion G protein-coupled receptor E1 (ADGRE1) OTQQ9Q7G AGRE1_HUMAN Increases Expression [5]
E3 ubiquitin/ISG15 ligase TRIM25 (TRIM25) OT35SG1R TRI25_HUMAN Affects Expression [5]
Protein-tyrosine kinase 2-beta (PTK2B) OTGAS0I8 FAK2_HUMAN Increases Expression [5]
Caprin-1 (CAPRIN1) OTEJAMS3 CAPR1_HUMAN Decreases Expression [5]
Protocadherin Fat 1 (FAT1) OTF174DH FAT1_HUMAN Affects Expression [5]
Inositol 1,4,5-trisphosphate receptor type 2 (ITPR2) OTPHGZ19 ITPR2_HUMAN Affects Expression [5]
Inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) OTGQ2AOJ ITPR3_HUMAN Decreases Expression [5]
Pumilio homolog 1 (PUM1) OTTMWP8L PUM1_HUMAN Decreases Expression [5]
Nuclear receptor coactivator 6 (NCOA6) OTOMIGTV NCOA6_HUMAN Decreases Expression [5]
Phosphatidate phosphatase LPIN1 (LPIN1) OTQ75KF2 LPIN1_HUMAN Decreases Expression [5]
H2.0-like homeobox protein (HLX) OT7DTH46 HLX_HUMAN Affects Expression [5]
LIM and SH3 domain protein 1 (LASP1) OT2QIDCL LASP1_HUMAN Increases Expression [5]
Rab3 GTPase-activating protein catalytic subunit (RAB3GAP1) OT4DQ8F2 RB3GP_HUMAN Decreases Expression [5]
Bromodomain-containing protein 3 (BRD3) OTRT44ZG BRD3_HUMAN Affects Expression [5]
Cyclin-dependent kinase 10 (CDK10) OTKP7TTR CDK10_HUMAN Affects Expression [5]
Ras-related protein Rab-35 (RAB35) OTRH1E2T RAB35_HUMAN Affects Expression [5]
P2Y purinoceptor 14 (P2RY14) OTDGZKED P2Y14_HUMAN Increases Expression [5]
Surfeit locus protein 1 (SURF1) OTAINRSS SURF1_HUMAN Affects Expression [5]
Protein SSXT (SS18) OTDKHN1E SSXT_HUMAN Decreases Expression [5]
Homeobox protein TGIF1 (TGIF1) OTN9VHAG TGIF1_HUMAN Decreases Expression [5]
2'-5'-oligoadenylate synthase-like protein (OASL) OTZ05YRP OASL_HUMAN Increases Expression [5]
Leukotriene B4 receptor 1 (LTB4R) OT3SRH4H LT4R1_HUMAN Affects Expression [5]
Mothers against decapentaplegic homolog 2 (SMAD2) OTC6VB4K SMAD2_HUMAN Decreases Expression [5]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Decreases Expression [5]
Serine/threonine-protein kinase N1 (PKN1) OTKMT6TM PKN1_HUMAN Increases Expression [5]
Mitogen-activated protein kinase 14 (MAPK14) OT5TCO3O MK14_HUMAN Affects Expression [5]
Bcl-2-related protein A1 (BCL2A1) OTWRYSNA B2LA1_HUMAN Increases Expression [5]
Lymphocyte antigen 6E (LY6E) OTMG16BZ LY6E_HUMAN Increases Expression [5]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Expression [5]
Protein NKG7 (NKG7) OTXDD006 NKG7_HUMAN Increases Expression [5]
Transcription factor NF-E2 45 kDa subunit (NFE2) OTLM94BI NFE2_HUMAN Increases Expression [5]
Syntaxin-1A (STX1A) OTSBUZB4 STX1A_HUMAN Decreases Expression [5]
Gamma-interferon-inducible protein 16 (IFI16) OT4SPU0U IF16_HUMAN Increases Expression [5]
Receptor-type tyrosine-protein phosphatase-like N (PTPRN) OTAP7NOL PTPRN_HUMAN Affects Expression [5]
Bridge-like lipid transfer protein family member 1 (BLTP1) OTGK09CX BLTP1_HUMAN Affects Expression [5]
Erythroid differentiation-related factor 1 (EDRF1) OTM7TWJZ EDRF1_HUMAN Decreases Expression [5]
B-cell CLL/lymphoma 7 protein family member A (BCL7A) OTYFUJTP BCL7A_HUMAN Decreases Expression [5]
Coiled-coil domain-containing protein 93 (CCDC93) OTTEMYL1 CCD93_HUMAN Decreases Expression [5]
Protein THEMIS2 (THEMIS2) OTI1OBLN THMS2_HUMAN Increases Expression [5]
Telomere-associated protein RIF1 (RIF1) OTPE49OE RIF1_HUMAN Decreases Expression [5]
Centrosomal protein of 135 kDa (CEP135) OT1O9XYJ CP135_HUMAN Decreases Expression [5]
Histone H2A type 2-A (H2AC18) OTCE5JC7 H2A2A_HUMAN Increases Expression [5]
Activity-dependent neuroprotector homeobox protein 2 (ADNP2) OT7NQWJK ADNP2_HUMAN Affects Expression [5]
Proton-coupled amino acid transporter 1 (SLC36A1) OTIEL5QZ S36A1_HUMAN Increases Expression [5]
Transmembrane channel-like protein 6 (TMC6) OTKH50J4 TMC6_HUMAN Increases Expression [5]
SUZ domain-containing protein 1 (SZRD1) OTJMEJWT SZRD1_HUMAN Decreases Expression [5]
Serine incorporator 5 (SERINC5) OT3COPVF SERC5_HUMAN Decreases Expression [5]
Homeodomain-interacting protein kinase 1 (HIPK1) OTSEA8RS HIPK1_HUMAN Decreases Expression [5]
Structural maintenance of chromosomes protein 5 (SMC5) OT91M6N4 SMC5_HUMAN Affects Expression [5]
Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2) OT1O2K47 LIRA2_HUMAN Affects Expression [5]
Leucine repeat adapter protein 25 (FAM89B) OT11J9HL LRA25_HUMAN Increases Expression [5]
ATP synthase mitochondrial F1 complex assembly factor 2 (ATPAF2) OTOMEQX6 ATPF2_HUMAN Affects Expression [5]
Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILRA3) OTBNQCOS LIRA3_HUMAN Increases Expression [5]
ATP-dependent RNA helicase DDX51 (DDX51) OTLMA7AH DDX51_HUMAN Affects Expression [5]
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) OTBIN5IP SCPDL_HUMAN Decreases Expression [5]
SERPINE1 mRNA-binding protein 1 (SERBP1) OTZVSU0X SERB1_HUMAN Affects Expression [5]
Protein LSM14 homolog A (LSM14A) OTFRHO9W LS14A_HUMAN Decreases Expression [5]
Nuclear protein MDM1 (MDM1) OTI9JUWA MDM1_HUMAN Decreases Expression [5]
Centrosome-associated protein ALMS1 (ALMS1) OTW66JKS ALMS1_HUMAN Decreases Expression [5]
GATA zinc finger domain-containing protein 1 (GATAD1) OT0UZ3EP GATD1_HUMAN Decreases Expression [5]
Transmembrane 9 superfamily member 4 (TM9SF4) OT85D4H9 TM9S4_HUMAN Decreases Expression [5]
Phytanoyl-CoA hydroxylase-interacting protein (PHYHIP) OTPC9JBM PHYIP_HUMAN Decreases Expression [5]
TBC1 domain family member 5 (TBC1D5) OTNHLLAX TBCD5_HUMAN Decreases Expression [5]
Rho GTPase-activating protein 45 (ARHGAP45) OTL86FEQ HMHA1_HUMAN Increases Expression [5]
Symplekin (SYMPK) OTYAUDXV SYMPK_HUMAN Affects Expression [5]
NEDD4-binding protein 2-like 2 (N4BP2L2) OTV2F04G N42L2_HUMAN Decreases Expression [5]
TATA-binding protein-associated factor 2N (TAF15) OTNE038N RBP56_HUMAN Decreases Expression [5]
DNA repair protein RAD50 (RAD50) OTYMU9G1 RAD50_HUMAN Affects Expression [5]
CUGBP Elav-like family member 1 (CELF1) OT6JQ5RS CELF1_HUMAN Affects Expression [5]
SWI/SNF complex subunit SMARCC1 (SMARCC1) OTUOMBE7 SMRC1_HUMAN Affects Expression [5]
Tumor necrosis factor receptor superfamily member 14 (TNFRSF14) OTB82PFO TNR14_HUMAN Increases Expression [5]
Transportin-1 (TNPO1) OT7W2CM8 TNPO1_HUMAN Decreases Expression [5]
Interferon regulatory factor 7 (IRF7) OTC1A2PQ IRF7_HUMAN Increases Expression [5]
Histone acetyltransferase KAT5 (KAT5) OTL7257A KAT5_HUMAN Increases Expression [5]
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) OT1IK0KA VPP1_HUMAN Increases Expression [5]
Interferon-stimulated gene 20 kDa protein (ISG20) OTCWRJJW ISG20_HUMAN Affects Expression [5]
Signal-induced proliferation-associated protein 1 (SIPA1) OTXY5RXC SIPA1_HUMAN Increases Expression [5]
Macrophage immunometabolism regulator (MACIR) OTPSW8Y8 MACIR_HUMAN Decreases Expression [5]
Ataxin-7-like protein 3B (ATXN7L3B) OTUYOYAR A7L3B_HUMAN Affects Expression [5]
Tribbles homolog 1 (TRIB1) OTPEO17G TRIB1_HUMAN Affects Expression [5]
Plakophilin-4 (PKP4) OTQHOF8L PKP4_HUMAN Decreases Expression [5]
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) OTVFRL8G TI17A_HUMAN Affects Expression [5]
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Decreases Expression [5]
Myeloid differentiation primary response protein MyD88 (MYD88) OTB4D6FL MYD88_HUMAN Increases Expression [5]
A-kinase anchor protein 9 (AKAP9) OT7Z2YRP AKAP9_HUMAN Decreases Expression [5]
Protein NipSnap homolog 1 (NIPSNAP1) OTKXKUT8 NIPS1_HUMAN Increases Expression [5]
Mitochondrial ribosome-associated GTPase 1 (MTG1) OTC9U1LI MTG1_HUMAN Affects Expression [5]
Eukaryotic translation initiation factor 2A (EIF2A) OTWXELQP EIF2A_HUMAN Affects Expression [5]
Cell adhesion molecule 1 (CADM1) OTRWG9QS CADM1_HUMAN Increases Expression [5]
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (DPH1) OT0QU3JY DPH1_HUMAN Increases Expression [5]
B-cell lymphoma/leukemia 11A (BCL11A) OTI6ZBP6 BC11A_HUMAN Decreases Expression [5]
Pinin (PNN) OT0HXICH PININ_HUMAN Decreases Expression [5]
Tudor domain-containing protein 3 (TDRD3) OTG83E2C TDRD3_HUMAN Decreases Expression [5]
Polyamine-transporting ATPase 13A3 (ATP13A3) OT5EGV3F AT133_HUMAN Affects Expression [5]
E3 ubiquitin-protein transferase RMND5A (RMND5A) OTXJ7HNB RMD5A_HUMAN Decreases Expression [5]
Pantothenate kinase 3 (PANK3) OT77CFJ6 PANK3_HUMAN Affects Expression [5]
Glyoxalase domain-containing protein 4 (GLOD4) OTBJKFXA GLOD4_HUMAN Affects Expression [5]
DNA polymerase delta subunit 4 (POLD4) OTG578YH DPOD4_HUMAN Increases Expression [5]
Nucleolar RNA helicase 2 (DDX21) OTV73GMZ DDX21_HUMAN Decreases Expression [5]
Structural maintenance of chromosomes protein 4 (SMC4) OTEJE6AG SMC4_HUMAN Decreases Expression [5]
Midasin (MDN1) OTNBSPTW MDN1_HUMAN Affects Expression [5]
Septin-11 (SEPTIN11) OTX2O0ZX SEP11_HUMAN Decreases Expression [5]
ATP-dependent RNA helicase DDX18 (DDX18) OTKB9C3S DDX18_HUMAN Affects Expression [5]
Spermine oxidase (SMOX) OT11E62Y SMOX_HUMAN Increases Expression [5]
Bcl-2-associated transcription factor 1 (BCLAF1) OT7T8H6A BCLF1_HUMAN Decreases Expression [5]
Regulator of telomere elongation helicase 1 (RTEL1) OTI3PJCT RTEL1_HUMAN Affects Expression [5]
Sacsin (SACS) OTZGXQ8A SACS_HUMAN Decreases Expression [5]
Alpha-catulin (CTNNAL1) OTESJ6JD CTNL1_HUMAN Decreases Expression [5]
Lysine-specific demethylase 5B (KDM5B) OT5DL94T KDM5B_HUMAN Affects Expression [5]
Deleted in malignant brain tumors 1 protein (DMBT1) OTVNU9D9 DMBT1_HUMAN Affects Expression [5]
CMRF35-like molecule 8 (CD300A) OTGBQE0Z CLM8_HUMAN Increases Expression [5]
Death-associated protein kinase 2 (DAPK2) OTWODUQG DAPK2_HUMAN Increases Expression [5]
Testis-specific Y-encoded-like protein 4 (TSPYL4) OTHCX9RH TSYL4_HUMAN Decreases Expression [5]
Phospholipase A and acyltransferase 4 (PLAAT4) OTI66SAJ PLAT4_HUMAN Increases Expression [5]
Proteasome activator complex subunit 2 (PSME2) OTYPP33T PSME2_HUMAN Increases Expression [5]
Histone-lysine N-methyltransferase 2B (KMT2B) OTMMAZQX KMT2B_HUMAN Affects Expression [5]
Nuclear pore complex-interacting protein family member A1 (NPIPA1) OTAUFC2I NPIA1_HUMAN Decreases Expression [5]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (MACF1) OTVIHD77 MACF1_HUMAN Affects Expression [5]
E3 ubiquitin-protein ligase TRIM33 (TRIM33) OT0KS4J7 TRI33_HUMAN Decreases Expression [5]
Myotubularin-related protein 6 (MTMR6) OTQPAWI3 MTMR6_HUMAN Decreases Expression [5]
PALM2-AKAP2 fusion protein (PALM2AKAP2) OTI618VF PLAK2_HUMAN Affects Expression [5]
Little elongation complex subunit 1 (ICE1) OTOXTBUH ICE1_HUMAN Affects Expression [5]
1-phosphatidylinositol 3-phosphate 5-kinase (PIKFYVE) OTO3HGAA FYV1_HUMAN Decreases Expression [5]
Rhomboid domain-containing protein 3 (RHBDD3) OTJ3OLC8 RHBD3_HUMAN Decreases Expression [5]
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) OTJBDX0Y VPP2_HUMAN Decreases Expression [5]
Transformation/transcription domain-associated protein (TRRAP) OT68OI2Y TRRAP_HUMAN Decreases Expression [5]
Disheveled-associated activator of morphogenesis 1 (DAAM1) OT0VHIYZ DAAM1_HUMAN Decreases Expression [5]
Diacylglycerol lipase-alpha (DAGLA) OT8GVKGM DGLA_HUMAN Affects Expression [5]
E3 ubiquitin-protein ligase RNF115 (RNF115) OT35B6L5 RN115_HUMAN Affects Expression [5]
Protein PRRC2C (PRRC2C) OTBX3MXM PRC2C_HUMAN Decreases Expression [5]
Sodium bicarbonate cotransporter 3 (SLC4A7) OT3Y35CV S4A7_HUMAN Affects Expression [5]
ATPase MORC2 (MORC2) OT52A8BJ MORC2_HUMAN Decreases Expression [5]
TNF receptor-associated factor 5 (TRAF5) OTSBTLO0 TRAF5_HUMAN Decreases Expression [6]
SH2B adapter protein 2 (SH2B2) OTEDHHDH SH2B2_HUMAN Increases Expression [6]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2) OT6Y1QZN IRAK2_HUMAN Increases Expression [6]
SH2 domain-containing protein 1A (SH2D1A) OTLU49I5 SH21A_HUMAN Decreases Expression [6]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [6]
HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA) OT7KZMP2 DRA_HUMAN Increases Expression [6]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) OTVVI3UI DQB1_HUMAN Increases Expression [6]
HLA class II histocompatibility antigen gamma chain (CD74) OTO16X4Q HG2A_HUMAN Increases Expression [6]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Expression [6]
Receptor-type tyrosine-protein phosphatase C (PTPRC) OT6KOR77 PTPRC_HUMAN Decreases Expression [6]
Lysosomal protective protein (CTSA) OT167UBM PPGB_HUMAN Increases Expression [6]
B-cell antigen receptor complex-associated protein alpha chain (CD79A) OTOJC8DV CD79A_HUMAN Increases Expression [6]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Decreases Expression [6]
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) OTAKDCMR KAPCA_HUMAN Increases Expression [6]
Transcription factor EB (TFEB) OTJUJJQY TFEB_HUMAN Increases Expression [6]
HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1) OT7OG7Y2 DPA1_HUMAN Increases Expression [6]
Midkine (MDK) OTF24HKC MK_HUMAN Increases Expression [6]
Myeloblastin (PRTN3) OT72MHP7 PRTN3_HUMAN Increases Expression [6]
Integrin alpha-3 (ITGA3) OTBCH21D ITA3_HUMAN Increases Expression [6]
Protein S100-A4 (S100A4) OTLRGFSQ S10A4_HUMAN Decreases Expression [6]
HLA class II histocompatibility antigen, DM beta chain (HLA-DMB) OT17HGXJ DMB_HUMAN Increases Expression [6]
Sorcin (SRI) OT4R3EAC SORCN_HUMAN Increases Expression [6]
MHC class II transactivator (CIITA) OTRJNZFO C2TA_HUMAN Increases Expression [6]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [6]
MAP kinase-activated protein kinase 2 (MAPKAPK2) OT460SBO MAPK2_HUMAN Increases Expression [6]
Rho GTPase-activating protein 8 (ARHGAP8) OT19H5Q9 RHG08_HUMAN Increases Expression [6]
Transcription factor RelB (RELB) OTU3QYEF RELB_HUMAN Increases Expression [6]
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) OT1YFEP1 TNR17_HUMAN Increases Expression [6]
Lactadherin (MFGE8) OTQKE41R MFGM_HUMAN Increases Expression [6]
HLA class II histocompatibility antigen, DR beta 5 chain (HLA-DRB5) OTUX5TWM DRB5_HUMAN Increases Expression [6]
Ras association domain-containing protein 6 (RASSF6) OT25GVWY RASF6_HUMAN Decreases Expression [6]
Rho-related GTP-binding protein RhoU (RHOU) OTERIAD4 RHOU_HUMAN Decreases Expression [6]
Protein lifeguard 1 (GRINA) OTMC1O66 LFG1_HUMAN Increases Expression [6]
Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1) OT6FQ1K3 M4K1_HUMAN Increases Expression [6]
P2X purinoceptor 5 (P2RX5) OTLBR20R P2RX5_HUMAN Increases Expression [6]
Ankyrin repeat and SOCS box protein 2 (ASB2) OTF9LV7L ASB2_HUMAN Increases Expression [6]
Leucine zipper transcription factor-like protein 1 (LZTFL1) OTIEIOEW LZTL1_HUMAN Increases Expression [6]
SLC2A4 regulator (SLC2A4RG) OTW3LX8D S2A4R_HUMAN Increases Expression [6]
Phospholipase A and acyltransferase 2 (PLAAT2) OTI5RMWB PLAT2_HUMAN Increases Expression [6]
Plexin-A1 (PLXNA1) OTN0BING PLXA1_HUMAN Increases Expression [6]
Nuclear receptor corepressor 2 (NCOR2) OTY917X0 NCOR2_HUMAN Increases Expression [6]
Dual specificity protein phosphatase 10 (DUSP10) OTNG467B DUS10_HUMAN Decreases Expression [6]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Increases Activity [11]
Integrin beta-2 (ITGB2) OTEKPEPR ITB2_HUMAN Decreases Expression [12]
Thrombomodulin (THBD) OT8VHLKY TRBM_HUMAN Increases Expression [13]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [14]
Tissue factor (F3) OT3MSU3B TF_HUMAN Decreases Expression [13]
Insulin-like growth factor-binding protein 3 (IGFBP3) OTIX63TX IBP3_HUMAN Increases Expression [15]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Activity [16]
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) OTQOUHVK CEAM6_HUMAN Increases Expression [12]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG) OT3FAU4Y PK3CG_HUMAN Increases Expression [13]
Transforming growth factor beta-2 proprotein (TGFB2) OTC0TXEP TGFB2_HUMAN Increases Secretion [9]
CCAAT/enhancer-binding protein epsilon (CEBPE) OTKZA25M CEBPE_HUMAN Increases Expression [12]
Occludin (OCLN) OTSUTVWL OCLN_HUMAN Increases Expression [17]
Bile acid receptor (NR1H4) OTWZLPTB NR1H4_HUMAN Increases Activity [11]
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⏷ Show the Full List of 511 DOT(s)
Indication(s) of Venetoclax
Disease Entry ICD 11 Status REF
Chronic lymphocytic leukaemia 2A82.0 Approved [4]
Venetoclax Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [18]
------------------------------------------------------------------------------------
Venetoclax Interacts with 11 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [19]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Activity [20]
Receptor-type tyrosine-protein kinase FLT3 (FLT3) OTMSRYMK FLT3_HUMAN Decreases Expression [21]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Cleavage [19]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Affects Folding [22]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [22]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [21]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Increases Expression [22]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Affects Folding [22]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Affects Binding [23]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Affects Response To Substance [24]
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⏷ Show the Full List of 11 DOT(s)

References

1 ClinicalTrials.gov (NCT04905407) Tamibarotene Plus Venetoclax/Azacitidine in Participants With Newly Diagnosed AML
2 ClinicalTrials.gov (NCT04797780) SY-1425 Plus Azacitidine in Participants With Newly Diagnosed RARA-positive Higher-Risk Myelodysplastic Syndrome. U.S. National Institutes of Health.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2648).
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
5 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
6 Induction of class II major histocompatibility complex expression in human multiple myeloma cells by retinoid. Haematologica. 2007 Jan;92(1):115-20.
7 All-trans retinoic acid induces in vitro angiogenesis via retinoic acid receptor: possible involvement of paracrine effects of endogenous vascular endothelial growth factor signaling. Endocrinology. 2007 Mar;148(3):1412-23. doi: 10.1210/en.2006-0900. Epub 2006 Dec 14.
8 Tamibarotene: a candidate retinoid drug for Alzheimer's disease. Biol Pharm Bull. 2012;35(8):1206-12.
9 RARalpha is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells. Int J Oncol. 2007 Aug;31(2):397-404.
10 New benzoic acid derivatives with retinoid activity: lack of direct correlation between biological activity and binding to cellular retinoic acid binding protein. Cancer Res. 1987 Jul 1;47(13):3523-7.
11 Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Sci Rep. 2014 Sep 26;4:6437. doi: 10.1038/srep06437.
12 Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and?mortality. EMBO Mol Med. 2016 Nov 2;8(11):1340-1359. doi: 10.15252/emmm.201606434. Print 2016 Nov.
13 Promyelocytic leukemia retinoid signaling targets regulate apoptosis,tissue factor and thrombomodulin expression. Haematologica. 2004 Mar;89(3):286-95.
14 Thyroid hormone regulation of apoptosis induced by retinoic acid in promyeloleukemic HL-60 cells: studies with retinoic acid receptor-specific and retinoid x receptor-specific ligands. Thyroid. 2000 Dec;10(12):1023-34. doi: 10.1089/thy.2000.10.1023.
15 Involvement of insulin-like growth factor binding protein-3 in the retinoic acid receptor-alpha-mediated inhibition of hepatocellular carcinoma cell proliferation. Cancer Lett. 2000 Apr 3;151(1):63-70. doi: 10.1016/s0304-3835(99)00410-3.
16 Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death. Mol Pharmacol. 2005 May;67(5):1808-17. doi: 10.1124/mol.104.005769. Epub 2005 Feb 9.
17 Epigenetic silencing of occludin promotes tumorigenic and metastatic properties of cancer cells via modulations of unique sets of apoptosis-associated genes. Cancer Res. 2006 Sep 15;66(18):9125-33. doi: 10.1158/0008-5472.CAN-06-1864.
18 Venclexta FDA label
19 ZCL-082, a boron-containing compound, induces apoptosis of non-Hodgkin's lymphoma via targeting p90 ribosomal S6 kinase 1/NF-B signaling pathway. Chem Biol Interact. 2022 Jan 5;351:109770. doi: 10.1016/j.cbi.2021.109770. Epub 2021 Nov 30.
20 Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options. Nat Genet. 2015 Sep;47(9):1020-1029. doi: 10.1038/ng.3362. Epub 2015 Jul 27.
21 HSP90 Inhibitor PU-H71 in Combination with BH3-Mimetics in the Treatment of Acute Myeloid Leukemia. Curr Issues Mol Biol. 2023 Aug 23;45(9):7011-7026. doi: 10.3390/cimb45090443.
22 Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells. Blood Cancer J. 2019 Jan 15;9(2):4. doi: 10.1038/s41408-018-0165-5.
23 Prospective Drug Candidates as Human Multidrug Transporter ABCG2 Inhibitors: an In Silico Drug Discovery Study. Cell Biochem Biophys. 2021 Jun;79(2):189-200. doi: 10.1007/s12013-021-00985-y. Epub 2021 May 5.
24 Statin-induced Mitochondrial Priming Sensitizes Multiple Myeloma Cells to BCL2 and MCL-1 Inhibitors. Cancer Res Commun. 2023 Dec 8;3(12):2497-2509. doi: 10.1158/2767-9764.CRC-23-0350.