Details of the Drug Combination

General Information of Drug Combination (ID: DCQ65TW)

• Drug Combination Name: Tamibarotene + Azacitidine
• Indication: Acute Myeloid Leukemia; Status: Phase 2 [1]
• Component Drugs:
  Tamibarotene (DM3G74J): Small molecular drug
  Azacitidine (DMTA5OE): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Tamibarotene

Disease Entry	ICD 11	Status	REF
T-cell leukaemia	2A90	Phase 3	[2]
Alzheimer disease	8A20	Phase 2/3	[3]

Tamibarotene Interacts with 2 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Retinoic acid receptor beta (RARB)	TTISP28	RARB_HUMAN	Modulator	[9]
Retinoic acid receptor alpha (RARA)	TTW38KT	RARA_HUMAN	Modulator	[9]

Tamibarotene Interacts with 511 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Retinoic acid receptor alpha (RARA)	OT192V9V	RARA_HUMAN	Decreases Response To Substance	[10]
Protein-glutamine gamma-glutamyltransferase 2 (TGM2)	OT6MFOWF	TGM2_HUMAN	Increases Activity	[11]
Golgin subfamily A member 8A (GOLGA8A)	OTSNE9EQ	GOG8A_HUMAN	Decreases Expression	[6]
TANK-binding kinase 1-binding protein 1 (TBKBP1)	OTXTU37H	TBKB1_HUMAN	Decreases Expression	[6]
Alternative prion protein (PRNP)	OTE85L1Q	APRIO_HUMAN	Affects Expression	[6]
Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS)	OTFBFPV4	ADAS_HUMAN	Affects Expression	[6]
Kinesin-like protein KIF2A (KIF2A)	OT2WQ6QD	KIF2A_HUMAN	Decreases Expression	[6]
Galectin-9 (LGALS9)	OT7MF91K	LEG9_HUMAN	Increases Expression	[6]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD)	OTOMP6TH	PK3CD_HUMAN	Increases Expression	[6]
Pyruvate dehydrogenase protein X component, mitochondrial (PDHX)	OTG7O271	ODPX_HUMAN	Affects Expression	[6]
Importin-5 (IPO5)	OTAK40ED	IPO5_HUMAN	Affects Expression	[6]
Serine/threonine-protein kinase PLK4 (PLK4)	OTV8KZDZ	PLK4_HUMAN	Decreases Expression	[6]
Leukocyte-specific transcript 1 protein (LST1)	OTUVG424	LST1_HUMAN	Increases Expression	[6]
Stearoyl-CoA desaturase (SCD)	OTB1073G	SCD_HUMAN	Affects Expression	[6]
Class E basic helix-loop-helix protein 40 (BHLHE40)	OTITX14U	BHE40_HUMAN	Affects Expression	[6]
Aquaporin-7 (AQP7)	OTSOSZEE	AQP7_HUMAN	Affects Expression	[6]
Nuclear envelope integral membrane protein 1 (NEMP1)	OTWN3S47	NEMP1_HUMAN	Decreases Expression	[6]
Thymosin beta-4, Y-chromosomal (TMSB4Y)	OT1BMJ6B	TYB4Y_HUMAN	Affects Expression	[6]
Segment polarity protein dishevelled homolog DVL-1 (DVL1)	OTD67RF1	DVL1_HUMAN	Decreases Expression	[6]
Torsin-1B (TOR1B)	OTNEL2PZ	TOR1B_HUMAN	Increases Expression	[6]
Syntaxin-16 (STX16)	OTM7TAOE	STX16_HUMAN	Affects Expression	[6]
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF1)	OTFK8KDP	NHRF1_HUMAN	Increases Expression	[6]
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3)	OTPGHZB9	IFIT3_HUMAN	Increases Expression	[6]
Antizyme inhibitor 1 (AZIN1)	OTX5W77I	AZIN1_HUMAN	Affects Expression	[6]
Protein transport protein Sec16A (SEC16A)	OTFNQ1ZU	SC16A_HUMAN	Decreases Expression	[6]
FYN-binding protein 1 (FYB1)	OT6345CH	FYB1_HUMAN	Affects Expression	[6]
Secretory carrier-associated membrane protein 1 (SCAMP1)	OTFS4IKJ	SCAM1_HUMAN	Affects Expression	[6]
Phospholipid scramblase 1 (PLSCR1)	OTGY9B5T	PLS1_HUMAN	Increases Expression	[6]
Axin-1 (AXIN1)	OTRGZGZ5	AXIN1_HUMAN	Increases Expression	[6]
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)	OT1Z1ZXE	OGT1_HUMAN	Decreases Expression	[6]
Monocarboxylate transporter 4 (SLC16A3)	OTDIXEXY	MOT4_HUMAN	Increases Expression	[6]
Regulator of G-protein signaling 16 (RGS16)	OTBKZASI	RGS16_HUMAN	Decreases Expression	[6]
N-glycosylase/DNA lyase (OGG1)	OTJ97TF3	OGG1_HUMAN	Increases Expression	[6]
mRNA cap guanine-N7 methyltransferase (RNMT)	OTIC02RT	MCES_HUMAN	Affects Expression	[6]
Cytoplasmic dynein 1 light intermediate chain 2 (DYNC1LI2)	OTR7WJES	DC1L2_HUMAN	Decreases Expression	[6]
CBP80/20-dependent translation initiation factor (CTIF)	OT7DU7WN	CTIF_HUMAN	Decreases Expression	[6]
Eukaryotic translation elongation factor 1 epsilon-1 (EEF1E1)	OTRA6XOB	MCA3_HUMAN	Decreases Expression	[6]
RNA-binding protein Musashi homolog 1 (MSI1)	OTAN4FSC	MSI1H_HUMAN	Affects Expression	[6]
Trans-Golgi network integral membrane protein 2 (TGOLN2)	OTM647IV	TGON2_HUMAN	Affects Expression	[6]
Protein-glutamine gamma-glutamyltransferase 5 (TGM5)	OTHI37BJ	TGM5_HUMAN	Increases Expression	[6]
Tumor necrosis factor ligand superfamily member 14 (TNFSF14)	OT5QRF09	TNF14_HUMAN	Increases Expression	[6]
Protein sprouty homolog 2 (SPRY2)	OTH0CRCZ	SPY2_HUMAN	Increases Expression	[6]
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial (GATC)	OTBLY3PP	GATC_HUMAN	Affects Expression	[6]
Cleavage and polyadenylation specificity factor subunit 5 (NUDT21)	OTZHKWAR	CPSF5_HUMAN	Affects Expression	[6]
Cyclic AMP-responsive element-binding protein 3 (CREB3)	OT9617UO	CREB3_HUMAN	Increases Expression	[6]
Docking protein 2 (DOK2)	OTIJ38UF	DOK2_HUMAN	Increases Expression	[6]
Protein O-GlcNAcase (OGA)	OT7ZBWT1	OGA_HUMAN	Decreases Expression	[6]
Exocyst complex component 3 (EXOC3)	OT8N3306	EXOC3_HUMAN	Affects Expression	[6]
Monocarboxylate transporter 2 (SLC16A7)	OT7OI36B	MOT2_HUMAN	Affects Expression	[6]
DNA polymerase zeta catalytic subunit (REV3L)	OT0OP8EJ	REV3L_HUMAN	Decreases Expression	[6]
Coiled-coil domain-containing protein 22 (CCDC22)	OT1A1ZXH	CCD22_HUMAN	Affects Expression	[6]
Ankyrin repeat domain-containing protein 17 (ANKRD17)	OTQ3DYEP	ANR17_HUMAN	Decreases Expression	[6]
Pre-mRNA-processing factor 40 homolog A (PRPF40A)	OT6EXJZN	PR40A_HUMAN	Affects Expression	[6]
Histone deacetylase complex subunit SAP30 (SAP30)	OT73OLML	SAP30_HUMAN	Decreases Expression	[6]
Serine/arginine-rich splicing factor 10 (SRSF10)	OTY6IJ11	SRS10_HUMAN	Decreases Expression	[6]
Protein CREG1 (CREG1)	OTRHJ8HK	CREG1_HUMAN	Increases Expression	[6]
U5 small nuclear ribonucleoprotein 200 kDa helicase (SNRNP200)	OTSAU864	U520_HUMAN	Decreases Expression	[6]
Short-chain dehydrogenase/reductase 3 (DHRS3)	OTSK1DTP	DHRS3_HUMAN	Increases Expression	[6]
Flotillin-1 (FLOT1)	OT0JPPJZ	FLOT1_HUMAN	Increases Expression	[6]
Triple functional domain protein (TRIO)	OT71X1AK	TRIO_HUMAN	Affects Expression	[6]
Protein transport protein Sec31A (SEC31A)	OT2U42AC	SC31A_HUMAN	Decreases Expression	[6]
Calmodulin-binding transcription activator 2 (CAMTA2)	OT6PIWF4	CMTA2_HUMAN	Increases Expression	[6]
Amyloid-beta A4 precursor protein-binding family B member 3 (APBB3)	OTNUTR0N	APBB3_HUMAN	Affects Expression	[6]
Adenosine deaminase (ADA)	OTOX2872	ADA_HUMAN	Increases Expression	[6]
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Affects Expression	[6]
Metalloproteinase inhibitor 1 (TIMP1)	OTOXC51H	TIMP1_HUMAN	Increases Expression	[6]
Cystatin-C (CST3)	OTNZ6AO4	CYTC_HUMAN	Increases Expression	[6]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[6]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Increases Expression	[6]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Increases Expression	[6]
Tissue alpha-L-fucosidase (FUCA1)	OTW71IK4	FUCO_HUMAN	Increases Expression	[6]
Metallothionein-1A (MT1A)	OTKBH52X	MT1A_HUMAN	Increases Expression	[6]
Cytochrome b-245 heavy chain (CYBB)	OTGSG868	CY24B_HUMAN	Increases Expression	[6]
Protein S100-A8 (S100A8)	OTVMOB3F	S10A8_HUMAN	Increases Expression	[6]
Plasminogen activator inhibitor 2 (SERPINB2)	OT72QLZB	PAI2_HUMAN	Decreases Expression	[6]
Ubiquitin-like protein ISG15 (ISG15)	OT53QQ7N	ISG15_HUMAN	Affects Expression	[6]
Endothelin-1 (EDN1)	OTZCACEG	EDN1_HUMAN	Increases Expression	[6]
Protein kinase C beta type (PRKCB)	OTYQ0656	KPCB_HUMAN	Increases Expression	[6]
Tyrosine-protein kinase Lck (LCK)	OT883FG9	LCK_HUMAN	Increases Expression	[6]
Tyrosine-protein kinase Fyn (FYN)	OTLSLVZS	FYN_HUMAN	Decreases Expression	[6]
Gelsolin (GSN)	OT4KS2UU	GELS_HUMAN	Increases Expression	[6]
Protein S100-A9 (S100A9)	OTOARHCS	S10A9_HUMAN	Increases Expression	[6]
Glutathione peroxidase 1 (GPX1)	OTE2O72Q	GPX1_HUMAN	Affects Expression	[6]
Tyrosine-protein kinase Fes/Fps (FES)	OTSE0XIF	FES_HUMAN	Affects Expression	[6]
Cathepsin D (CTSD)	OTQZ36F3	CATD_HUMAN	Increases Expression	[6]
Annexin A2 (ANXA2)	OTFNS0CC	ANXA2_HUMAN	Decreases Expression	[6]
Galactose-1-phosphate uridylyltransferase (GALT)	OTCATU66	GALT_HUMAN	Increases Expression	[6]
Tyrosine-protein kinase Lyn (LYN)	OTP686K2	LYN_HUMAN	Increases Expression	[6]
Heat shock protein HSP 90-beta (HSP90AB1)	OTR69EG7	HS90B_HUMAN	Affects Expression	[6]
Extracellular superoxide dismutase (SOD3)	OTIOZQAB	SODE_HUMAN	Decreases Expression	[6]
Pleckstrin (PLEK)	OTB73XXA	PLEK_HUMAN	Increases Expression	[6]
Tyrosine-protein kinase HCK (HCK)	OTRL6OSI	HCK_HUMAN	Increases Expression	[6]
Galectin-1 (LGALS1)	OT8LDFWR	LEG1_HUMAN	Increases Expression	[6]
Fructose-1,6-bisphosphatase 1 (FBP1)	OTQBANEP	F16P1_HUMAN	Increases Expression	[6]
Glutathione S-transferase Mu 1 (GSTM1)	OTSBF2MO	GSTM1_HUMAN	Increases Expression	[6]
Clathrin light chain B (CLTB)	OTPW9VRE	CLCB_HUMAN	Increases Expression	[6]
Tyrosine-protein kinase Fgr (FGR)	OTCUYU9F	FGR_HUMAN	Increases Expression	[6]
Adenosine receptor A3 (ADORA3)	OTHO1BLK	AA3R_HUMAN	Affects Expression	[6]
Choriogonadotropin subunit beta 3 (CGB3)	OTVM2SU3	CGB3_HUMAN	Decreases Expression	[6]
Transcriptional activator Myb (MYB)	OTJH64IV	MYB_HUMAN	Affects Expression	[6]
HLA class I histocompatibility antigen, C alpha chain (HLA-C)	OTV38BUJ	HLAC_HUMAN	Increases Expression	[6]
Osteopontin (SPP1)	OTJGC23Y	OSTP_HUMAN	Increases Expression	[6]
Receptor-type tyrosine-protein phosphatase F (PTPRF)	OTH5KF2D	PTPRF_HUMAN	Decreases Expression	[6]
Interferon regulatory factor 1 (IRF1)	OT43DI6J	IRF1_HUMAN	Increases Expression	[6]
Laminin subunit gamma-1 (LAMC1)	OTIG527N	LAMC1_HUMAN	Decreases Expression	[6]
Integrin alpha-M (ITGAM)	OTAG6HWU	ITAM_HUMAN	Increases Expression	[6]
Serine/threonine-protein kinase pim-1 (PIM1)	OTWEKXTU	PIM1_HUMAN	Increases Expression	[6]
Fibroblast growth factor receptor 1 (FGFR1)	OT4GLCXW	FGFR1_HUMAN	Decreases Expression	[6]
DNA topoisomerase 1 (TOP1)	OT51O0CF	TOP1_HUMAN	Decreases Expression	[6]
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Affects Expression	[6]
Eosinophil peroxidase (EPX)	OTFNDFOK	PERE_HUMAN	Decreases Expression	[6]
Ornithine decarboxylase (ODC1)	OTNDAGRR	DCOR_HUMAN	Decreases Expression	[6]
Proliferating cell nuclear antigen (PCNA)	OTHZ1RIA	PCNA_HUMAN	Affects Expression	[6]
Nucleoprotein TPR (TPR)	OTUBBA4W	TPR_HUMAN	Decreases Expression	[6]
High affinity immunoglobulin gamma Fc receptor I (FCGR1A)	OTOBCS2O	FCGR1_HUMAN	Affects Expression	[6]
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1)	OTQY6ZSF	HEM1_HUMAN	Increases Expression	[6]
C-C motif chemokine 4 (CCL4)	OT6B8P25	CCL4_HUMAN	Increases Expression	[6]
Cytochrome b-245 light chain (CYBA)	OT16N9ZO	CY24A_HUMAN	Increases Expression	[6]
C-C motif chemokine 5 (CCL5)	OTSCA5CK	CCL5_HUMAN	Increases Expression	[6]
Integrin alpha-4 (ITGA4)	OTSCAL0V	ITA4_HUMAN	Affects Expression	[6]
Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3)	OTM8EG6H	AT1A3_HUMAN	Affects Expression	[6]
HLA class I histocompatibility antigen, alpha chain E (HLA-E)	OTX1CTFB	HLAE_HUMAN	Increases Expression	[6]
Collagen alpha-2(XI) chain (COL11A2)	OT3BQUBH	COBA2_HUMAN	Affects Expression	[6]
L-selectin (SELL)	OT6RAJZR	LYAM1_HUMAN	Increases Expression	[6]
Neutrophil cytosol factor 1 (NCF1)	OTMHT3G6	NCF1_HUMAN	Increases Expression	[6]
Endoplasmin (HSP90B1)	OT02XLBR	ENPL_HUMAN	Decreases Expression	[6]
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Affects Expression	[6]
Small ribosomal subunit protein uS5 (RPS2)	OTSMTZVB	RS2_HUMAN	Increases Expression	[6]
Aggrecan core protein (ACAN)	OTUOCW8K	PGCA_HUMAN	Affects Expression	[6]
Cyclic AMP-responsive element-binding protein 1 (CREB1)	OT1MDLA1	CREB1_HUMAN	Affects Expression	[6]
SH2/SH3 adapter protein NCK1 (NCK1)	OTKYZ4OP	NCK1_HUMAN	Affects Expression	[6]
Histone H1.3 (H1-3)	OTT7VPRB	H13_HUMAN	Affects Expression	[6]
NADPH--cytochrome P450 reductase (POR)	OTVIDOCH	NCPR_HUMAN	Increases Expression	[6]
Rho-related GTP-binding protein RhoQ (RHOQ)	OTUBTU57	RHOQ_HUMAN	Affects Expression	[6]
Bactericidal permeability-increasing protein (BPI)	OTNN9LJ5	BPI_HUMAN	Increases Expression	[6]
Sphingomyelin phosphodiesterase (SMPD1)	OTZSMA54	ASM_HUMAN	Increases Expression	[6]
CCAAT/enhancer-binding protein beta (CEBPB)	OTM9MQIA	CEBPB_HUMAN	Increases Expression	[6]
HLA class I histocompatibility antigen, alpha chain G (HLA-G)	OTMLK1KN	HLAG_HUMAN	Increases Expression	[6]
S-adenosylmethionine decarboxylase proenzyme (AMD1)	OTKAGZY3	DCAM_HUMAN	Decreases Expression	[6]
Insulin-like growth factor-binding protein 2 (IGFBP2)	OTG1P60E	IBP2_HUMAN	Affects Expression	[6]
Protein SON (SON)	OT9VWV18	SON_HUMAN	Affects Expression	[6]
Regulator of chromosome condensation (RCC1)	OT25AGMB	RCC1_HUMAN	Decreases Expression	[6]
Leukocyte surface antigen CD53 (CD53)	OT9U5OXJ	CD53_HUMAN	Increases Expression	[6]
Glutathione hydrolase 1 proenzyme (GGT1)	OTYDA1Z7	GGT1_HUMAN	Increases Expression	[6]
Plasma membrane calcium-transporting ATPase 1 (ATP2B1)	OT5MXG9W	AT2B1_HUMAN	Affects Expression	[6]
Serine protease inhibitor Kazal-type 2 (SPINK2)	OTSFBT0G	ISK2_HUMAN	Decreases Expression	[6]
Azurocidin (AZU1)	OTHXU264	CAP7_HUMAN	Increases Expression	[6]
B-cell receptor CD22 (CD22)	OTXDJR9T	CD22_HUMAN	Affects Expression	[6]
Transcription factor BTF3 (BTF3)	OT5ZZFJL	BTF3_HUMAN	Affects Expression	[6]
Arachidonate 5-lipoxygenase-activating protein (ALOX5AP)	OT0DH40W	AL5AP_HUMAN	Increases Expression	[6]
Ras-related protein Rab-4A (RAB4A)	OT7BL9WW	RAB4A_HUMAN	Decreases Expression	[6]
Ras-related protein Rab-5A (RAB5A)	OTFR2KM4	RAB5A_HUMAN	Affects Expression	[6]
Ras-related protein Rab-6A (RAB6A)	OTLS86J5	RAB6A_HUMAN	Affects Expression	[6]
Interferon-induced GTP-binding protein Mx2 (MX2)	OT05NF37	MX2_HUMAN	Affects Expression	[6]
Lamin-B1 (LMNB1)	OT100T3P	LMNB1_HUMAN	Affects Expression	[6]
Endothelin-2 (EDN2)	OTQ7RCPI	EDN2_HUMAN	Increases Expression	[6]
Cysteine and glycine-rich protein 1 (CSRP1)	OTUS7RM2	CSRP1_HUMAN	Affects Expression	[6]
Diamine acetyltransferase 1 (SAT1)	OT52AU22	SAT1_HUMAN	Increases Expression	[6]
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)	OTGYVSGU	PIMT_HUMAN	Affects Expression	[6]
Alpha-(1,3)-fucosyltransferase 4 (FUT4)	OTIBXRTL	FUT4_HUMAN	Increases Expression	[6]
Small proline-rich protein 2D (SPRR2D)	OT47THNK	SPR2D_HUMAN	Affects Expression	[6]
cAMP-dependent protein kinase catalytic subunit beta (PRKACB)	OT6RMDCE	KAPCB_HUMAN	Decreases Expression	[6]
Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5)	OTZNYEKF	GTR5_HUMAN	Increases Expression	[6]
Splicing factor, proline- and glutamine-rich (SFPQ)	OTLCIAPJ	SFPQ_HUMAN	Decreases Expression	[6]
Ribosomal protein S6 kinase beta-1 (RPS6KB1)	OTAELNGX	KS6B1_HUMAN	Affects Expression	[6]
Tyrosine-protein kinase JAK1 (JAK1)	OT0X3D17	JAK1_HUMAN	Affects Expression	[6]
Eukaryotic translation initiation factor 4B (EIF4B)	OTE8TXA8	IF4B_HUMAN	Decreases Expression	[6]
Endothelial transcription factor GATA-2 (GATA2)	OTBP2QQ2	GATA2_HUMAN	Decreases Expression	[6]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Increases Expression	[6]
COUP transcription factor 2 (NR2F2)	OTJFS67N	COT2_HUMAN	Decreases Expression	[6]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)	OTDRV63V	GA45A_HUMAN	Decreases Expression	[6]
Adenomatous polyposis coli protein (APC)	OTKV0TIK	APC_HUMAN	Decreases Expression	[6]
Nuclear transcription factor Y subunit beta (NFYB)	OTXSE7KW	NFYB_HUMAN	Decreases Expression	[6]
Metallothionein-3 (MT3)	OTVCZ7HI	MT3_HUMAN	Affects Expression	[6]
Integrin beta-7 (ITGB7)	OT33UUKU	ITB7_HUMAN	Increases Expression	[6]
Tyrosine-protein phosphatase non-receptor type 3 (PTPN3)	OTSLZBVY	PTN3_HUMAN	Affects Expression	[6]
Adenylate kinase 4, mitochondrial (AK4)	OTA0T02Q	KAD4_HUMAN	Decreases Expression	[6]
Proteasome subunit beta type-9 (PSMB9)	OTFV57T8	PSB9_HUMAN	Increases Expression	[6]
Grancalcin (GCA)	OTAJ7ZHG	GRAN_HUMAN	Increases Expression	[6]
Progranulin (GRN)	OTXXSJ53	GRN_HUMAN	Increases Expression	[6]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)	OTG0TTX7	CD38_HUMAN	Increases Expression	[6]
2'-5'-oligoadenylate synthase 2 (OAS2)	OT64CCTM	OAS2_HUMAN	Increases Expression	[6]
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B)	OTFIHQGD	2AAB_HUMAN	Affects Expression	[6]
High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G)	OTBZBL9Y	FCERG_HUMAN	Increases Expression	[6]
M-phase inducer phosphatase 1 (CDC25A)	OTSLKKCO	MPIP1_HUMAN	Decreases Expression	[6]
Leukocyte elastase inhibitor (SERPINB1)	OT5RDUFO	ILEU_HUMAN	Increases Expression	[6]
Aldehyde dehydrogenase X, mitochondrial (ALDH1B1)	OTXW9TE2	AL1B1_HUMAN	Affects Expression	[6]
Coronin-1A (CORO1A)	OTVAZOHC	COR1A_HUMAN	Increases Expression	[6]
S-adenosylmethionine synthase isoform type-2 (MAT2A)	OTFJMIQR	METK2_HUMAN	Decreases Expression	[6]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2)	OTOB6J6R	RIR2_HUMAN	Affects Expression	[6]
Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B)	OTCJD51H	FCG2B_HUMAN	Affects Expression	[6]
C-C chemokine receptor type 1 (CCR1)	OT4FC783	CCR1_HUMAN	Increases Expression	[6]
C-X-C chemokine receptor type 5 (CXCR5)	OTVBCQZX	CXCR5_HUMAN	Increases Expression	[6]
4-hydroxyphenylpyruvate dioxygenase (HPD)	OTDKD5EH	HPPD_HUMAN	Increases Expression	[6]
Intercellular adhesion molecule 3 (ICAM3)	OTTZ5A5D	ICAM3_HUMAN	Increases Expression	[6]
Lymphocyte-specific protein 1 (LSP1)	OTSPSIFO	LSP1_HUMAN	Increases Expression	[6]
Fibrillin-2 (FBN2)	OT3KYJQL	FBN2_HUMAN	Decreases Expression	[6]
Glutaredoxin-1 (GLRX)	OT0QHTAR	GLRX1_HUMAN	Increases Expression	[6]
Choline kinase alpha (CHKA)	OT7FVO3Z	CHKA_HUMAN	Decreases Expression	[6]
Serine/threonine-protein kinase receptor R3 (ACVRL1)	OT1HQR88	ACVL1_HUMAN	Decreases Expression	[6]
Breast cancer type 1 susceptibility protein (BRCA1)	OT5BN6VH	BRCA1_HUMAN	Decreases Expression	[6]
V-type proton ATPase catalytic subunit A (ATP6V1A)	OTYZ2S9E	VATA_HUMAN	Affects Expression	[6]
Macrophage-capping protein (CAPG)	OTJ86KI6	CAPG_HUMAN	Increases Expression	[6]
Replication factor C subunit 5 (RFC5)	OTAD79RT	RFC5_HUMAN	Affects Expression	[6]
Cyclin-F (CCNF)	OTJFVU43	CCNF_HUMAN	Decreases Expression	[6]
Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3)	OTARRES9	IF2G_HUMAN	Affects Expression	[6]
Protein kinase C iota type (PRKCI)	OTKBAVT3	KPCI_HUMAN	Decreases Expression	[6]
Enoyl-CoA delta isomerase 1, mitochondrial (ECI1)	OTRQTK84	ECI1_HUMAN	Affects Expression	[6]
Lamina-associated polypeptide 2, isoform alpha (TMPO)	OTL68EL4	LAP2A_HUMAN	Affects Expression	[6]
Signal transducer and activator of transcription 1-alpha/beta (STAT1)	OTLMBUZ6	STAT1_HUMAN	Increases Expression	[6]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB)	OTO8JQJA	PK3CB_HUMAN	Affects Expression	[6]
Translocon-associated protein subunit alpha (SSR1)	OTQ6GDL2	SSRA_HUMAN	Affects Expression	[6]
Transcriptional regulator ATRX (ATRX)	OT77RSQW	ATRX_HUMAN	Decreases Expression	[6]
Radiation-inducible immediate-early gene IEX-1 (IER3)	OTZJI5FZ	IEX1_HUMAN	Increases Expression	[6]
Serpin B10 (SERPINB10)	OT5ZM0X6	SPB10_HUMAN	Decreases Expression	[6]
Excitatory amino acid transporter 4 (SLC1A6)	OTRSPH8U	EAA4_HUMAN	Decreases Expression	[6]
Phosphatidylinositol transfer protein beta isoform (PITPNB)	OTNM6T78	PIPNB_HUMAN	Affects Expression	[6]
Cyclin-dependent kinase 8 (CDK8)	OTMC3CWX	CDK8_HUMAN	Affects Expression	[6]
Glutamate dehydrogenase 2, mitochondrial (GLUD2)	OTF3GGYY	DHE4_HUMAN	Affects Expression	[6]
Homeobox even-skipped homolog protein 1 (EVX1)	OT4A84VD	EVX1_HUMAN	Decreases Expression	[6]
CCAAT/enhancer-binding protein delta (CEBPD)	OTNBIPMY	CEBPD_HUMAN	Increases Expression	[6]
Glycogen synthase kinase-3 beta (GSK3B)	OTL3L14B	GSK3B_HUMAN	Affects Expression	[6]
Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ)	OTOODWTU	GNAQ_HUMAN	Affects Expression	[6]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 (GNG4)	OTOXNDI9	GBG4_HUMAN	Decreases Expression	[6]
Sulfate transporter (SLC26A2)	OTJNHNTO	S26A2_HUMAN	Affects Expression	[6]
Serpin B8 (SERPINB8)	OT5T4Y5R	SPB8_HUMAN	Affects Expression	[6]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)	OT4PXBTA	TNF10_HUMAN	Increases Expression	[6]
Lipopolysaccharide-responsive and beige-like anchor protein (LRBA)	OTOUZN9G	LRBA_HUMAN	Affects Expression	[6]
Poly(A) polymerase alpha (PAPOLA)	OTPHD65D	PAPOA_HUMAN	Affects Expression	[6]
Ras-related protein Rab-5C (RAB5C)	OTQE5QQ2	RAB5C_HUMAN	Increases Expression	[6]
Breast cancer type 2 susceptibility protein (BRCA2)	OTF1XSV1	BRCA2_HUMAN	Decreases Expression	[6]
Signal transducer and activator of transcription 5B (STAT5B)	OTZVPEBT	STA5B_HUMAN	Decreases Expression	[6]
Chloride channel protein ClC-Ka (CLCNKA)	OT7Q0RI9	CLCKA_HUMAN	Decreases Expression	[6]
Ribosomal protein S6 kinase alpha-3 (RPS6KA3)	OTYJNNMD	KS6A3_HUMAN	Decreases Expression	[6]
Cyclin-G1 (CCNG1)	OT17IA9L	CCNG1_HUMAN	Affects Expression	[6]
6-phosphogluconate dehydrogenase, decarboxylating (PGD)	OTVG296F	6PGD_HUMAN	Increases Expression	[6]
Nuclear cap-binding protein subunit 2 (NCBP2)	OTQNZTE4	NCBP2_HUMAN	Decreases Expression	[6]
DNA mismatch repair protein Msh6 (MSH6)	OT46FP09	MSH6_HUMAN	Decreases Expression	[6]
Hexokinase-3 (HK3)	OTZKONGB	HXK3_HUMAN	Increases Expression	[6]
Protein FosB (FOSB)	OTW6C05J	FOSB_HUMAN	Increases Expression	[6]
CCAAT/enhancer-binding protein gamma (CEBPG)	OTGNAX3H	CEBPG_HUMAN	Decreases Expression	[6]
Geranylgeranyl transferase type-2 subunit beta (RABGGTB)	OTZ25I2W	PGTB2_HUMAN	Decreases Expression	[6]
E3 ubiquitin-protein ligase TTC3 (TTC3)	OTTR9WUC	TTC3_HUMAN	Decreases Expression	[6]
Monocarboxylate transporter 1 (SLC16A1)	OTW1UTZ7	MOT1_HUMAN	Affects Expression	[6]
Protein HIRA (HIRA)	OTON40EJ	HIRA_HUMAN	Affects Expression	[6]
Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1)	OTYHXLWZ	BCAT1_HUMAN	Affects Expression	[6]
Allograft inflammatory factor 1 (AIF1)	OTGES18F	AIF1_HUMAN	Increases Expression	[6]
Bax inhibitor 1 (TMBIM6)	OTP7PI9L	BI1_HUMAN	Affects Expression	[6]
Microfibril-associated glycoprotein 3 (MFAP3)	OTFAU0YL	MFAP3_HUMAN	Affects Expression	[6]
Nucleosome assembly protein 1-like 1 (NAP1L1)	OTI7WBZV	NP1L1_HUMAN	Decreases Expression	[6]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Expression	[6]
Protein arginine N-methyltransferase 2 (PRMT2)	OT63JZCI	ANM2_HUMAN	Increases Expression	[6]
AP-1 complex subunit sigma-2 (AP1S2)	OTZHJFYI	AP1S2_HUMAN	Increases Expression	[6]
ADP-ribosylation factor-like protein 4C (ARL4C)	OTQ3QNNU	ARL4C_HUMAN	Decreases Expression	[6]
Ribose-phosphate pyrophosphokinase 1 (PRPS1)	OTN3A6CN	PRPS1_HUMAN	Affects Expression	[6]
NPC intracellular cholesterol transporter 2 (NPC2)	OTE9UEJC	NPC2_HUMAN	Increases Expression	[6]
Nuclear transport factor 2 (NUTF2)	OT8VA2ZF	NTF2_HUMAN	Affects Expression	[6]
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB)	OTYFTYFR	PP1B_HUMAN	Decreases Expression	[6]
ADP-ribosylation factor 6 (ARF6)	OTVV7KJO	ARF6_HUMAN	Affects Expression	[6]
Histone H4 (H4C1)	OTB71W46	H4_HUMAN	Affects Expression	[6]
Ras-related protein Rab-1A (RAB1A)	OTKPHRD0	RAB1A_HUMAN	Affects Expression	[6]
Elongation factor 1-alpha 1 (EEF1A1)	OT00THXS	EF1A1_HUMAN	Increases Expression	[6]
Glutathione S-transferase omega-1 (GSTO1)	OTUJ93MN	GSTO1_HUMAN	Increases Expression	[6]
DNA-dependent protein kinase catalytic subunit (PRKDC)	OTJVS4EG	PRKDC_HUMAN	Decreases Expression	[6]
Protein BTG2 (BTG2)	OTZF6K1H	BTG2_HUMAN	Increases Expression	[6]
Interferon-induced 35 kDa protein (IFI35)	OTV9RZ53	IN35_HUMAN	Increases Expression	[6]
Serine/arginine-rich splicing factor 3 (SRSF3)	OTOFT707	SRSF3_HUMAN	Affects Expression	[6]
Rho GTPase-activating protein 4 (ARHGAP4)	OTXV053R	RHG04_HUMAN	Increases Expression	[6]
Forkhead box protein O4 (FOXO4)	OT90X9LN	FOXO4_HUMAN	Increases Expression	[6]
Interferon regulatory factor 9 (IRF9)	OTK4MYQJ	IRF9_HUMAN	Increases Expression	[6]
Runt-related transcription factor 1 (RUNX1)	OTU7J84H	RUNX1_HUMAN	Affects Expression	[6]
N-acetylgalactosamine kinase (GALK2)	OTHR35JF	GALK2_HUMAN	Decreases Expression	[6]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)	OTCO26FV	HMCS1_HUMAN	Affects Expression	[6]
Transgelin (TAGLN)	OTAEZ0KP	TAGL_HUMAN	Affects Expression	[6]
DNA topoisomerase 2-beta (TOP2B)	OTDHKQZ8	TOP2B_HUMAN	Affects Expression	[6]
Dystonin (DST)	OTHZBM4X	DYST_HUMAN	Decreases Expression	[6]
Tumor necrosis factor alpha-induced protein 2 (TNFAIP2)	OTRZH80H	TNAP2_HUMAN	Increases Expression	[6]
Antigen peptide transporter 1 (TAP1)	OTJL27PW	TAP1_HUMAN	Increases Expression	[6]
Antigen peptide transporter 2 (TAP2)	OTWSYFI7	TAP2_HUMAN	Increases Expression	[6]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Affects Expression	[6]
Protein kinase C delta type (PRKCD)	OTSEH90E	KPCD_HUMAN	Increases Expression	[6]
Amidophosphoribosyltransferase (PPAT)	OTXK12ZB	PUR1_HUMAN	Decreases Expression	[6]
Glutamine--fructose-6-phosphate aminotransferase 1 (GFPT1)	OTQBDO45	GFPT1_HUMAN	Affects Expression	[6]
Early growth response protein 3 (EGR3)	OTGPJIRA	EGR3_HUMAN	Increases Expression	[6]
Early activation antigen CD69 (CD69)	OTGJHSVP	CD69_HUMAN	Affects Expression	[6]
Protocadherin-1 (PCDH1)	OT7KDEL3	PCDH1_HUMAN	Affects Expression	[6]
Interleukin-10 receptor subunit beta (IL10RB)	OT5AN6ZR	I10R2_HUMAN	Increases Expression	[6]
CMRF35-like molecule 6 (CD300C)	OT4BSR7D	CLM6_HUMAN	Increases Expression	[6]
Histone-binding protein RBBP4 (RBBP4)	OTG3BT3M	RBBP4_HUMAN	Affects Expression	[6]
Neuroblast differentiation-associated protein AHNAK (AHNAK)	OT6KH1WG	AHNK_HUMAN	Decreases Expression	[6]
Bone marrow stromal antigen 2 (BST2)	OTU4LCJV	BST2_HUMAN	Affects Expression	[6]
Tastin (TROAP)	OTC8CE0R	TROAP_HUMAN	Decreases Expression	[6]
Nucleosome-remodeling factor subunit BPTF (BPTF)	OTD1RZAD	BPTF_HUMAN	Affects Expression	[6]
Interleukin enhancer-binding factor 3 (ILF3)	OTKMZ5K5	ILF3_HUMAN	Decreases Expression	[6]
Transcription initiation factor TFIID subunit 10 (TAF10)	OTEPTEZ3	TAF10_HUMAN	Increases Expression	[6]
PR domain zinc finger protein 2 (PRDM2)	OT8L7CGX	PRDM2_HUMAN	Affects Expression	[6]
Lymphocyte cytosolic protein 2 (LCP2)	OT57KE22	LCP2_HUMAN	Increases Expression	[6]
Krueppel-like factor 10 (KLF10)	OT4F4UGS	KLF10_HUMAN	Decreases Expression	[6]
Liprin-alpha-1 (PPFIA1)	OTYYFA9C	LIPA1_HUMAN	Decreases Expression	[6]
Serine/threonine-protein kinase PAK 1 (PAK1)	OT17LZNZ	PAK1_HUMAN	Increases Expression	[6]
Serine/threonine-protein kinase PAK 2 (PAK2)	OTLUNCIH	PAK2_HUMAN	Affects Expression	[6]
Chromobox protein homolog 3 (CBX3)	OTOP9RLD	CBX3_HUMAN	Affects Expression	[6]
DNA excision repair protein ERCC-8 (ERCC8)	OT0T4WKI	ERCC8_HUMAN	Decreases Expression	[6]
Src-like-adapter (SLA)	OTV17DY2	SLAP1_HUMAN	Increases Expression	[6]
Voltage-gated potassium channel subunit beta-2 (KCNAB2)	OTH115IE	KCAB2_HUMAN	Affects Expression	[6]
S-phase kinase-associated protein 2 (SKP2)	OTD5B41X	SKP2_HUMAN	Decreases Expression	[6]
Metastasis-associated protein MTA1 (MTA1)	OTBHW3S9	MTA1_HUMAN	Decreases Expression	[6]
Origin recognition complex subunit 2 (ORC2)	OTLIYP8M	ORC2_HUMAN	Decreases Expression	[6]
Integrin-linked protein kinase (ILK)	OTYG2FD1	ILK_HUMAN	Increases Expression	[6]
DNA-binding protein Ikaros (IKZF1)	OTCW1FKL	IKZF1_HUMAN	Affects Expression	[6]
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)	OT404F9K	FKBP5_HUMAN	Decreases Expression	[6]
Mothers against decapentaplegic homolog 4 (SMAD4)	OTWQWCKG	SMAD4_HUMAN	Decreases Expression	[6]
V-type proton ATPase 116 kDa subunit a 3 (TCIRG1)	OTU1AIEW	VPP3_HUMAN	Increases Expression	[6]
Mediator of RNA polymerase II transcription subunit 21 (MED21)	OT0XWLMK	MED21_HUMAN	Affects Expression	[6]
Cullin-1 (CUL1)	OTXPE1UZ	CUL1_HUMAN	Decreases Expression	[6]
Ras-related protein Rab-31 (RAB31)	OTMLXQZ0	RAB31_HUMAN	Increases Expression	[6]
Bleomycin hydrolase (BLMH)	OT2QPWQJ	BLMH_HUMAN	Decreases Expression	[6]
Krueppel-like factor 9 (KLF9)	OTBFEJRQ	KLF9_HUMAN	Decreases Expression	[6]
Runt-related transcription factor 2 (RUNX2)	OT97RQQM	RUNX2_HUMAN	Decreases Expression	[6]
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1)	OTRN55RE	KCC1A_HUMAN	Increases Expression	[6]
Eukaryotic translation initiation factor 3 subunit A (EIF3A)	OTFABY9G	EIF3A_HUMAN	Decreases Expression	[6]
Transcription factor Dp-1 (TFDP1)	OT6RZ7VT	TFDP1_HUMAN	Affects Expression	[6]
Transcription factor Dp-2 (TFDP2)	OTKQFX5H	TFDP2_HUMAN	Decreases Expression	[6]
Eukaryotic initiation factor 4A-II (EIF4A2)	OT08H03R	IF4A2_HUMAN	Decreases Expression	[6]
Adhesion G protein-coupled receptor E1 (ADGRE1)	OTQQ9Q7G	AGRE1_HUMAN	Increases Expression	[6]
E3 ubiquitin/ISG15 ligase TRIM25 (TRIM25)	OT35SG1R	TRI25_HUMAN	Affects Expression	[6]
Protein-tyrosine kinase 2-beta (PTK2B)	OTGAS0I8	FAK2_HUMAN	Increases Expression	[6]
Caprin-1 (CAPRIN1)	OTEJAMS3	CAPR1_HUMAN	Decreases Expression	[6]
Protocadherin Fat 1 (FAT1)	OTF174DH	FAT1_HUMAN	Affects Expression	[6]
Inositol 1,4,5-trisphosphate receptor type 2 (ITPR2)	OTPHGZ19	ITPR2_HUMAN	Affects Expression	[6]
Inositol 1,4,5-trisphosphate receptor type 3 (ITPR3)	OTGQ2AOJ	ITPR3_HUMAN	Decreases Expression	[6]
Pumilio homolog 1 (PUM1)	OTTMWP8L	PUM1_HUMAN	Decreases Expression	[6]
Nuclear receptor coactivator 6 (NCOA6)	OTOMIGTV	NCOA6_HUMAN	Decreases Expression	[6]
Phosphatidate phosphatase LPIN1 (LPIN1)	OTQ75KF2	LPIN1_HUMAN	Decreases Expression	[6]
H2.0-like homeobox protein (HLX)	OT7DTH46	HLX_HUMAN	Affects Expression	[6]
LIM and SH3 domain protein 1 (LASP1)	OT2QIDCL	LASP1_HUMAN	Increases Expression	[6]
Rab3 GTPase-activating protein catalytic subunit (RAB3GAP1)	OT4DQ8F2	RB3GP_HUMAN	Decreases Expression	[6]
Bromodomain-containing protein 3 (BRD3)	OTRT44ZG	BRD3_HUMAN	Affects Expression	[6]
Cyclin-dependent kinase 10 (CDK10)	OTKP7TTR	CDK10_HUMAN	Affects Expression	[6]
Ras-related protein Rab-35 (RAB35)	OTRH1E2T	RAB35_HUMAN	Affects Expression	[6]
P2Y purinoceptor 14 (P2RY14)	OTDGZKED	P2Y14_HUMAN	Increases Expression	[6]
Surfeit locus protein 1 (SURF1)	OTAINRSS	SURF1_HUMAN	Affects Expression	[6]
Protein SSXT (SS18)	OTDKHN1E	SSXT_HUMAN	Decreases Expression	[6]
Homeobox protein TGIF1 (TGIF1)	OTN9VHAG	TGIF1_HUMAN	Decreases Expression	[6]
2'-5'-oligoadenylate synthase-like protein (OASL)	OTZ05YRP	OASL_HUMAN	Increases Expression	[6]
Leukotriene B4 receptor 1 (LTB4R)	OT3SRH4H	LT4R1_HUMAN	Affects Expression	[6]
Mothers against decapentaplegic homolog 2 (SMAD2)	OTC6VB4K	SMAD2_HUMAN	Decreases Expression	[6]
Nuclear factor erythroid 2-related factor 2 (NFE2L2)	OT0HENJ5	NF2L2_HUMAN	Decreases Expression	[6]
Serine/threonine-protein kinase N1 (PKN1)	OTKMT6TM	PKN1_HUMAN	Increases Expression	[6]
Mitogen-activated protein kinase 14 (MAPK14)	OT5TCO3O	MK14_HUMAN	Affects Expression	[6]
Bcl-2-related protein A1 (BCL2A1)	OTWRYSNA	B2LA1_HUMAN	Increases Expression	[6]
Lymphocyte antigen 6E (LY6E)	OTMG16BZ	LY6E_HUMAN	Increases Expression	[6]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Increases Expression	[6]
Protein NKG7 (NKG7)	OTXDD006	NKG7_HUMAN	Increases Expression	[6]
Transcription factor NF-E2 45 kDa subunit (NFE2)	OTLM94BI	NFE2_HUMAN	Increases Expression	[6]
Syntaxin-1A (STX1A)	OTSBUZB4	STX1A_HUMAN	Decreases Expression	[6]
Gamma-interferon-inducible protein 16 (IFI16)	OT4SPU0U	IF16_HUMAN	Increases Expression	[6]
Receptor-type tyrosine-protein phosphatase-like N (PTPRN)	OTAP7NOL	PTPRN_HUMAN	Affects Expression	[6]
Bridge-like lipid transfer protein family member 1 (BLTP1)	OTGK09CX	BLTP1_HUMAN	Affects Expression	[6]
Erythroid differentiation-related factor 1 (EDRF1)	OTM7TWJZ	EDRF1_HUMAN	Decreases Expression	[6]
B-cell CLL/lymphoma 7 protein family member A (BCL7A)	OTYFUJTP	BCL7A_HUMAN	Decreases Expression	[6]
Coiled-coil domain-containing protein 93 (CCDC93)	OTTEMYL1	CCD93_HUMAN	Decreases Expression	[6]
Protein THEMIS2 (THEMIS2)	OTI1OBLN	THMS2_HUMAN	Increases Expression	[6]
Telomere-associated protein RIF1 (RIF1)	OTPE49OE	RIF1_HUMAN	Decreases Expression	[6]
Centrosomal protein of 135 kDa (CEP135)	OT1O9XYJ	CP135_HUMAN	Decreases Expression	[6]
Histone H2A type 2-A (H2AC18)	OTCE5JC7	H2A2A_HUMAN	Increases Expression	[6]
Activity-dependent neuroprotector homeobox protein 2 (ADNP2)	OT7NQWJK	ADNP2_HUMAN	Affects Expression	[6]
Proton-coupled amino acid transporter 1 (SLC36A1)	OTIEL5QZ	S36A1_HUMAN	Increases Expression	[6]
Transmembrane channel-like protein 6 (TMC6)	OTKH50J4	TMC6_HUMAN	Increases Expression	[6]
SUZ domain-containing protein 1 (SZRD1)	OTJMEJWT	SZRD1_HUMAN	Decreases Expression	[6]
Serine incorporator 5 (SERINC5)	OT3COPVF	SERC5_HUMAN	Decreases Expression	[6]
Homeodomain-interacting protein kinase 1 (HIPK1)	OTSEA8RS	HIPK1_HUMAN	Decreases Expression	[6]
Structural maintenance of chromosomes protein 5 (SMC5)	OT91M6N4	SMC5_HUMAN	Affects Expression	[6]
Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2)	OT1O2K47	LIRA2_HUMAN	Affects Expression	[6]
Leucine repeat adapter protein 25 (FAM89B)	OT11J9HL	LRA25_HUMAN	Increases Expression	[6]
ATP synthase mitochondrial F1 complex assembly factor 2 (ATPAF2)	OTOMEQX6	ATPF2_HUMAN	Affects Expression	[6]
Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILRA3)	OTBNQCOS	LIRA3_HUMAN	Increases Expression	[6]
ATP-dependent RNA helicase DDX51 (DDX51)	OTLMA7AH	DDX51_HUMAN	Affects Expression	[6]
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH)	OTBIN5IP	SCPDL_HUMAN	Decreases Expression	[6]
SERPINE1 mRNA-binding protein 1 (SERBP1)	OTZVSU0X	SERB1_HUMAN	Affects Expression	[6]
Protein LSM14 homolog A (LSM14A)	OTFRHO9W	LS14A_HUMAN	Decreases Expression	[6]
Nuclear protein MDM1 (MDM1)	OTI9JUWA	MDM1_HUMAN	Decreases Expression	[6]
Centrosome-associated protein ALMS1 (ALMS1)	OTW66JKS	ALMS1_HUMAN	Decreases Expression	[6]
GATA zinc finger domain-containing protein 1 (GATAD1)	OT0UZ3EP	GATD1_HUMAN	Decreases Expression	[6]
Transmembrane 9 superfamily member 4 (TM9SF4)	OT85D4H9	TM9S4_HUMAN	Decreases Expression	[6]
Phytanoyl-CoA hydroxylase-interacting protein (PHYHIP)	OTPC9JBM	PHYIP_HUMAN	Decreases Expression	[6]
TBC1 domain family member 5 (TBC1D5)	OTNHLLAX	TBCD5_HUMAN	Decreases Expression	[6]
Rho GTPase-activating protein 45 (ARHGAP45)	OTL86FEQ	HMHA1_HUMAN	Increases Expression	[6]
Symplekin (SYMPK)	OTYAUDXV	SYMPK_HUMAN	Affects Expression	[6]
NEDD4-binding protein 2-like 2 (N4BP2L2)	OTV2F04G	N42L2_HUMAN	Decreases Expression	[6]
TATA-binding protein-associated factor 2N (TAF15)	OTNE038N	RBP56_HUMAN	Decreases Expression	[6]
DNA repair protein RAD50 (RAD50)	OTYMU9G1	RAD50_HUMAN	Affects Expression	[6]
CUGBP Elav-like family member 1 (CELF1)	OT6JQ5RS	CELF1_HUMAN	Affects Expression	[6]
SWI/SNF complex subunit SMARCC1 (SMARCC1)	OTUOMBE7	SMRC1_HUMAN	Affects Expression	[6]
Tumor necrosis factor receptor superfamily member 14 (TNFRSF14)	OTB82PFO	TNR14_HUMAN	Increases Expression	[6]
Transportin-1 (TNPO1)	OT7W2CM8	TNPO1_HUMAN	Decreases Expression	[6]
Interferon regulatory factor 7 (IRF7)	OTC1A2PQ	IRF7_HUMAN	Increases Expression	[6]
Histone acetyltransferase KAT5 (KAT5)	OTL7257A	KAT5_HUMAN	Increases Expression	[6]
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1)	OT1IK0KA	VPP1_HUMAN	Increases Expression	[6]
Interferon-stimulated gene 20 kDa protein (ISG20)	OTCWRJJW	ISG20_HUMAN	Affects Expression	[6]
Signal-induced proliferation-associated protein 1 (SIPA1)	OTXY5RXC	SIPA1_HUMAN	Increases Expression	[6]
Macrophage immunometabolism regulator (MACIR)	OTPSW8Y8	MACIR_HUMAN	Decreases Expression	[6]
Ataxin-7-like protein 3B (ATXN7L3B)	OTUYOYAR	A7L3B_HUMAN	Affects Expression	[6]
Tribbles homolog 1 (TRIB1)	OTPEO17G	TRIB1_HUMAN	Affects Expression	[6]
Plakophilin-4 (PKP4)	OTQHOF8L	PKP4_HUMAN	Decreases Expression	[6]
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A)	OTVFRL8G	TI17A_HUMAN	Affects Expression	[6]
Cell division control protein 6 homolog (CDC6)	OTX93FE7	CDC6_HUMAN	Decreases Expression	[6]
Myeloid differentiation primary response protein MyD88 (MYD88)	OTB4D6FL	MYD88_HUMAN	Increases Expression	[6]
A-kinase anchor protein 9 (AKAP9)	OT7Z2YRP	AKAP9_HUMAN	Decreases Expression	[6]
Protein NipSnap homolog 1 (NIPSNAP1)	OTKXKUT8	NIPS1_HUMAN	Increases Expression	[6]
Mitochondrial ribosome-associated GTPase 1 (MTG1)	OTC9U1LI	MTG1_HUMAN	Affects Expression	[6]
Eukaryotic translation initiation factor 2A (EIF2A)	OTWXELQP	EIF2A_HUMAN	Affects Expression	[6]
Cell adhesion molecule 1 (CADM1)	OTRWG9QS	CADM1_HUMAN	Increases Expression	[6]
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (DPH1)	OT0QU3JY	DPH1_HUMAN	Increases Expression	[6]
B-cell lymphoma/leukemia 11A (BCL11A)	OTI6ZBP6	BC11A_HUMAN	Decreases Expression	[6]
Pinin (PNN)	OT0HXICH	PININ_HUMAN	Decreases Expression	[6]
Tudor domain-containing protein 3 (TDRD3)	OTG83E2C	TDRD3_HUMAN	Decreases Expression	[6]
Polyamine-transporting ATPase 13A3 (ATP13A3)	OT5EGV3F	AT133_HUMAN	Affects Expression	[6]
E3 ubiquitin-protein transferase RMND5A (RMND5A)	OTXJ7HNB	RMD5A_HUMAN	Decreases Expression	[6]
Pantothenate kinase 3 (PANK3)	OT77CFJ6	PANK3_HUMAN	Affects Expression	[6]
Glyoxalase domain-containing protein 4 (GLOD4)	OTBJKFXA	GLOD4_HUMAN	Affects Expression	[6]
DNA polymerase delta subunit 4 (POLD4)	OTG578YH	DPOD4_HUMAN	Increases Expression	[6]
Nucleolar RNA helicase 2 (DDX21)	OTV73GMZ	DDX21_HUMAN	Decreases Expression	[6]
Structural maintenance of chromosomes protein 4 (SMC4)	OTEJE6AG	SMC4_HUMAN	Decreases Expression	[6]
Midasin (MDN1)	OTNBSPTW	MDN1_HUMAN	Affects Expression	[6]
Septin-11 (SEPTIN11)	OTX2O0ZX	SEP11_HUMAN	Decreases Expression	[6]
ATP-dependent RNA helicase DDX18 (DDX18)	OTKB9C3S	DDX18_HUMAN	Affects Expression	[6]
Spermine oxidase (SMOX)	OT11E62Y	SMOX_HUMAN	Increases Expression	[6]
Bcl-2-associated transcription factor 1 (BCLAF1)	OT7T8H6A	BCLF1_HUMAN	Decreases Expression	[6]
Regulator of telomere elongation helicase 1 (RTEL1)	OTI3PJCT	RTEL1_HUMAN	Affects Expression	[6]
Sacsin (SACS)	OTZGXQ8A	SACS_HUMAN	Decreases Expression	[6]
Alpha-catulin (CTNNAL1)	OTESJ6JD	CTNL1_HUMAN	Decreases Expression	[6]
Lysine-specific demethylase 5B (KDM5B)	OT5DL94T	KDM5B_HUMAN	Affects Expression	[6]
Deleted in malignant brain tumors 1 protein (DMBT1)	OTVNU9D9	DMBT1_HUMAN	Affects Expression	[6]
CMRF35-like molecule 8 (CD300A)	OTGBQE0Z	CLM8_HUMAN	Increases Expression	[6]
Death-associated protein kinase 2 (DAPK2)	OTWODUQG	DAPK2_HUMAN	Increases Expression	[6]
Testis-specific Y-encoded-like protein 4 (TSPYL4)	OTHCX9RH	TSYL4_HUMAN	Decreases Expression	[6]
Phospholipase A and acyltransferase 4 (PLAAT4)	OTI66SAJ	PLAT4_HUMAN	Increases Expression	[6]
Proteasome activator complex subunit 2 (PSME2)	OTYPP33T	PSME2_HUMAN	Increases Expression	[6]
Histone-lysine N-methyltransferase 2B (KMT2B)	OTMMAZQX	KMT2B_HUMAN	Affects Expression	[6]
Nuclear pore complex-interacting protein family member A1 (NPIPA1)	OTAUFC2I	NPIA1_HUMAN	Decreases Expression	[6]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (MACF1)	OTVIHD77	MACF1_HUMAN	Affects Expression	[6]
E3 ubiquitin-protein ligase TRIM33 (TRIM33)	OT0KS4J7	TRI33_HUMAN	Decreases Expression	[6]
Myotubularin-related protein 6 (MTMR6)	OTQPAWI3	MTMR6_HUMAN	Decreases Expression	[6]
PALM2-AKAP2 fusion protein (PALM2AKAP2)	OTI618VF	PLAK2_HUMAN	Affects Expression	[6]
Little elongation complex subunit 1 (ICE1)	OTOXTBUH	ICE1_HUMAN	Affects Expression	[6]
1-phosphatidylinositol 3-phosphate 5-kinase (PIKFYVE)	OTO3HGAA	FYV1_HUMAN	Decreases Expression	[6]
Rhomboid domain-containing protein 3 (RHBDD3)	OTJ3OLC8	RHBD3_HUMAN	Decreases Expression	[6]
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2)	OTJBDX0Y	VPP2_HUMAN	Decreases Expression	[6]
Transformation/transcription domain-associated protein (TRRAP)	OT68OI2Y	TRRAP_HUMAN	Decreases Expression	[6]
Disheveled-associated activator of morphogenesis 1 (DAAM1)	OT0VHIYZ	DAAM1_HUMAN	Decreases Expression	[6]
Diacylglycerol lipase-alpha (DAGLA)	OT8GVKGM	DGLA_HUMAN	Affects Expression	[6]
E3 ubiquitin-protein ligase RNF115 (RNF115)	OT35B6L5	RN115_HUMAN	Affects Expression	[6]
Protein PRRC2C (PRRC2C)	OTBX3MXM	PRC2C_HUMAN	Decreases Expression	[6]
Sodium bicarbonate cotransporter 3 (SLC4A7)	OT3Y35CV	S4A7_HUMAN	Affects Expression	[6]
ATPase MORC2 (MORC2)	OT52A8BJ	MORC2_HUMAN	Decreases Expression	[6]
TNF receptor-associated factor 5 (TRAF5)	OTSBTLO0	TRAF5_HUMAN	Decreases Expression	[7]
SH2B adapter protein 2 (SH2B2)	OTEDHHDH	SH2B2_HUMAN	Increases Expression	[7]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2)	OT6Y1QZN	IRAK2_HUMAN	Increases Expression	[7]
SH2 domain-containing protein 1A (SH2D1A)	OTLU49I5	SH21A_HUMAN	Decreases Expression	[7]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)	OTYG179K	PR15A_HUMAN	Increases Expression	[7]
HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA)	OT7KZMP2	DRA_HUMAN	Increases Expression	[7]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1)	OTVVI3UI	DQB1_HUMAN	Increases Expression	[7]
HLA class II histocompatibility antigen gamma chain (CD74)	OTO16X4Q	HG2A_HUMAN	Increases Expression	[7]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Decreases Expression	[7]
Receptor-type tyrosine-protein phosphatase C (PTPRC)	OT6KOR77	PTPRC_HUMAN	Decreases Expression	[7]
Lysosomal protective protein (CTSA)	OT167UBM	PPGB_HUMAN	Increases Expression	[7]
B-cell antigen receptor complex-associated protein alpha chain (CD79A)	OTOJC8DV	CD79A_HUMAN	Increases Expression	[7]
CD44 antigen (CD44)	OT9TTJ41	CD44_HUMAN	Decreases Expression	[7]
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)	OTAKDCMR	KAPCA_HUMAN	Increases Expression	[7]
Transcription factor EB (TFEB)	OTJUJJQY	TFEB_HUMAN	Increases Expression	[7]
HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1)	OT7OG7Y2	DPA1_HUMAN	Increases Expression	[7]
Midkine (MDK)	OTF24HKC	MK_HUMAN	Increases Expression	[7]
Myeloblastin (PRTN3)	OT72MHP7	PRTN3_HUMAN	Increases Expression	[7]
Integrin alpha-3 (ITGA3)	OTBCH21D	ITA3_HUMAN	Increases Expression	[7]
Protein S100-A4 (S100A4)	OTLRGFSQ	S10A4_HUMAN	Decreases Expression	[7]
HLA class II histocompatibility antigen, DM beta chain (HLA-DMB)	OT17HGXJ	DMB_HUMAN	Increases Expression	[7]
Sorcin (SRI)	OT4R3EAC	SORCN_HUMAN	Increases Expression	[7]
MHC class II transactivator (CIITA)	OTRJNZFO	C2TA_HUMAN	Increases Expression	[7]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[7]
MAP kinase-activated protein kinase 2 (MAPKAPK2)	OT460SBO	MAPK2_HUMAN	Increases Expression	[7]
Rho GTPase-activating protein 8 (ARHGAP8)	OT19H5Q9	RHG08_HUMAN	Increases Expression	[7]
Transcription factor RelB (RELB)	OTU3QYEF	RELB_HUMAN	Increases Expression	[7]
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)	OT1YFEP1	TNR17_HUMAN	Increases Expression	[7]
Lactadherin (MFGE8)	OTQKE41R	MFGM_HUMAN	Increases Expression	[7]
HLA class II histocompatibility antigen, DR beta 5 chain (HLA-DRB5)	OTUX5TWM	DRB5_HUMAN	Increases Expression	[7]
Ras association domain-containing protein 6 (RASSF6)	OT25GVWY	RASF6_HUMAN	Decreases Expression	[7]
Rho-related GTP-binding protein RhoU (RHOU)	OTERIAD4	RHOU_HUMAN	Decreases Expression	[7]
Protein lifeguard 1 (GRINA)	OTMC1O66	LFG1_HUMAN	Increases Expression	[7]
Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1)	OT6FQ1K3	M4K1_HUMAN	Increases Expression	[7]
P2X purinoceptor 5 (P2RX5)	OTLBR20R	P2RX5_HUMAN	Increases Expression	[7]
Ankyrin repeat and SOCS box protein 2 (ASB2)	OTF9LV7L	ASB2_HUMAN	Increases Expression	[7]
Leucine zipper transcription factor-like protein 1 (LZTFL1)	OTIEIOEW	LZTL1_HUMAN	Increases Expression	[7]
SLC2A4 regulator (SLC2A4RG)	OTW3LX8D	S2A4R_HUMAN	Increases Expression	[7]
Phospholipase A and acyltransferase 2 (PLAAT2)	OTI5RMWB	PLAT2_HUMAN	Increases Expression	[7]
Plexin-A1 (PLXNA1)	OTN0BING	PLXA1_HUMAN	Increases Expression	[7]
Nuclear receptor corepressor 2 (NCOR2)	OTY917X0	NCOR2_HUMAN	Increases Expression	[7]
Dual specificity protein phosphatase 10 (DUSP10)	OTNG467B	DUS10_HUMAN	Decreases Expression	[7]
Estrogen receptor (ESR1)	OTKLU61J	ESR1_HUMAN	Increases Activity	[12]
Integrin beta-2 (ITGB2)	OTEKPEPR	ITB2_HUMAN	Decreases Expression	[13]
Thrombomodulin (THBD)	OT8VHLKY	TRBM_HUMAN	Increases Expression	[14]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[15]
Tissue factor (F3)	OT3MSU3B	TF_HUMAN	Decreases Expression	[14]
Insulin-like growth factor-binding protein 3 (IGFBP3)	OTIX63TX	IBP3_HUMAN	Increases Expression	[16]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Increases Activity	[17]
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6)	OTQOUHVK	CEAM6_HUMAN	Increases Expression	[13]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG)	OT3FAU4Y	PK3CG_HUMAN	Increases Expression	[14]
Transforming growth factor beta-2 proprotein (TGFB2)	OTC0TXEP	TGFB2_HUMAN	Increases Secretion	[10]
CCAAT/enhancer-binding protein epsilon (CEBPE)	OTKZA25M	CEBPE_HUMAN	Increases Expression	[13]
Occludin (OCLN)	OTSUTVWL	OCLN_HUMAN	Increases Expression	[18]
Bile acid receptor (NR1H4)	OTWZLPTB	NR1H4_HUMAN	Increases Activity	[12]

Indication(s) of Azacitidine

Disease Entry	ICD 11	Status	REF
Acute myelogenous leukaemia	2A41	Approved	[4]
Chronic myelomonocytic leukemia	N.A.	Approved	[4]
Leukemia	N.A.	Approved	[4]
Myelodysplastic syndrome	2A37	Approved	[5]
Myeloproliferative neoplasm	2A20	Approved	[4]
Plasma cell myeloma	2A83.1	Approved	[4]

Azacitidine Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
DNA [cytosine-5]-methyltransferase (DNMT)	TTHVCUP	NOUNIPROTAC	Inhibitor	[23]

Azacitidine Interacts with 2 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytidine aminohydrolase (CDA)	DEKEDRC	CDD_HUMAN	Metabolism	[24]
Cytidine deaminase (cdd)	DEYILK4	E0TLJ6_MYCHH	Metabolism	[25]

Azacitidine Interacts with 275 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Affects Expression	[26]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Increases Expression	[27]
Cytochrome P450 1A2 (CYP1A2)	OTLLBX48	CP1A2_HUMAN	Increases Expression	[27]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Increases Expression	[27]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Increases Expression	[27]
Sulfotransferase 1C2 (SULT1C2)	OT07MMZS	ST1C2_HUMAN	Increases Expression	[19]
Phospholipid phosphatase 1 (PLPP1)	OT0IIMI5	PLPP1_HUMAN	Increases Expression	[19]
Tectonin beta-propeller repeat-containing protein 2 (TECPR2)	OT1UFECZ	TCPR2_HUMAN	Increases Expression	[19]
TBC1 domain family member 4 (TBC1D4)	OTK66C40	TBCD4_HUMAN	Decreases Expression	[19]
Multiple epidermal growth factor-like domains protein 6 (MEGF6)	OTEUYTP1	MEGF6_HUMAN	Decreases Expression	[19]
Stanniocalcin-2 (STC2)	OT86YP8G	STC2_HUMAN	Decreases Expression	[19]
Integrin beta-2 (ITGB2)	OTEKPEPR	ITB2_HUMAN	Decreases Expression	[19]
Protein S100-A9 (S100A9)	OTOARHCS	S10A9_HUMAN	Increases Expression	[19]
Receptor-type tyrosine-protein phosphatase C (PTPRC)	OT6KOR77	PTPRC_HUMAN	Increases Expression	[19]
Delta-aminolevulinic acid dehydratase (ALAD)	OTHM9GSH	HEM2_HUMAN	Decreases Expression	[19]
Hepatocyte growth factor (HGF)	OTGHUA23	HGF_HUMAN	Increases Expression	[19]
Heat shock 70 kDa protein 6 (HSPA6)	OTH4S7WB	HSP76_HUMAN	Increases Expression	[19]
Gamma-aminobutyric acid receptor subunit beta-1 (GABRB1)	OT4L2SSB	GBRB1_HUMAN	Increases Expression	[19]
Transcription factor E3 (TFE3)	OTM99ZWH	TFE3_HUMAN	Increases Expression	[19]
Pro-thyrotropin-releasing hormone (TRH)	OT02UY2V	TRH_HUMAN	Decreases Expression	[19]
Protein S100-P (S100P)	OTJCXNJG	S100P_HUMAN	Increases Expression	[19]
Protein PML (PML)	OT6SM2GD	PML_HUMAN	Increases Expression	[19]
DNA-binding protein inhibitor ID-1 (ID1)	OTKGNZN5	ID1_HUMAN	Increases Expression	[19]
Cyclin-dependent kinase 4 inhibitor B (CDKN2B)	OTAG24N1	CDN2B_HUMAN	Decreases Methylation	[19]
LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1)	OT729S0T	LIMS1_HUMAN	Increases Expression	[19]
E3 SUMO-protein ligase RanBP2 (RANBP2)	OTFG5CVF	RBP2_HUMAN	Increases Expression	[19]
Cyclin-dependent kinase inhibitor 1C (CDKN1C)	OTASTJ3Q	CDN1C_HUMAN	Increases Expression	[19]
Ras-related protein Rab-13 (RAB13)	OTIQ484I	RAB13_HUMAN	Decreases Methylation	[19]
Lysozyme C (LYZ)	OTD7H0G6	LYSC_HUMAN	Increases Expression	[19]
Claudin-10 (CLDN10)	OT2CVAKY	CLD10_HUMAN	Decreases Expression	[19]
Sushi repeat-containing protein SRPX (SRPX)	OT5B9LXS	SRPX_HUMAN	Decreases Expression	[19]
Protein delta homolog 1 (DLK1)	OTE1VLNB	DLK1_HUMAN	Decreases Methylation	[19]
DNA-binding protein inhibitor ID-3 (ID3)	OTUULW5Z	ID3_HUMAN	Increases Expression	[19]
Collagen alpha-1(XIV) chain (COL14A1)	OTLNJ13O	COEA1_HUMAN	Increases Expression	[19]
Equilibrative nucleoside transporter 2 (SLC29A2)	OTUAOB8T	S29A2_HUMAN	Decreases Expression	[19]
Cytohesin-1 (CYTH1)	OTYH9NRJ	CYH1_HUMAN	Increases Expression	[19]
C3a anaphylatoxin chemotactic receptor (C3AR1)	OT8J0TF8	C3AR_HUMAN	Increases Expression	[19]
DNA dC->dU-editing enzyme APOBEC-3F (APOBEC3F)	OT750IJM	ABC3F_HUMAN	Increases Expression	[19]
Angiogenic factor with G patch and FHA domains 1 (AGGF1)	OTA7U2T8	AGGF1_HUMAN	Increases Expression	[19]
E3 ubiquitin-protein ligase Praja-1 (PJA1)	OTFKTMEI	PJA1_HUMAN	Increases Expression	[19]
Caspase-10 (CASP10)	OTE6J88E	CASPA_HUMAN	Increases Expression	[19]
Tetraspanin-32 (TSPAN32)	OTSXW7EW	TSN32_HUMAN	Decreases Expression	[19]
Tribbles homolog 1 (TRIB1)	OTPEO17G	TRIB1_HUMAN	Decreases Expression	[19]
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF)	OTT5JX1F	LITAF_HUMAN	Decreases Expression	[19]
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A)	OTVTB5R5	PI51A_HUMAN	Decreases Expression	[19]
Centromere protein O (CENPO)	OTXAH83Y	CENPO_HUMAN	Increases Expression	[19]
Iron-sulfur cluster assembly 1 homolog, mitochondrial (ISCA1)	OTU230MC	ISCA1_HUMAN	Increases Expression	[19]
E3 ubiquitin-protein ligase TRIM8 (TRIM8)	OTS6JFR0	TRIM8_HUMAN	Increases Expression	[19]
Uncharacterized protein C6orf62 (C6ORF62)	OTGK4G35	CF062_HUMAN	Increases Expression	[19]
Metal transporter CNNM2 (CNNM2)	OTZHO8WU	CNNM2_HUMAN	Decreases Expression	[19]
Pantothenate kinase 3 (PANK3)	OT77CFJ6	PANK3_HUMAN	Decreases Expression	[19]
DNA dC->dU-editing enzyme APOBEC-3G (APOBEC3G)	OT410VP5	ABC3G_HUMAN	Increases Expression	[19]
Neuritin (NRN1)	OTWJG0SO	NRN1_HUMAN	Decreases Expression	[19]
NTF2-related export protein 2 (NXT2)	OTK82YVT	NXT2_HUMAN	Increases Expression	[19]
THUMP domain-containing protein 1 (THUMPD1)	OTKU8KWH	THUM1_HUMAN	Increases Expression	[19]
Protein FAM8A1 (FAM8A1)	OT1QVTGS	FA8A1_HUMAN	Increases Expression	[19]
Type 2 lactosamine alpha-2,3-sialyltransferase (ST3GAL6)	OTB17Q43	SIA10_HUMAN	Increases Expression	[19]
Methionine-R-sulfoxide reductase B2, mitochondrial (MSRB2)	OTURGRA8	MSRB2_HUMAN	Increases Expression	[19]
Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1)	OTJCX8K9	MD1L1_HUMAN	Decreases Expression	[19]
Signal-regulatory protein beta-1 (SIRPB1)	OTGHALWJ	SIRB1_HUMAN	Decreases Expression	[20]
Syntenin-1 (SDCBP)	OTS3NCC5	SDCB1_HUMAN	Decreases Expression	[20]
Complexin-1 (CPLX1)	OT7UIGTP	CPLX1_HUMAN	Increases Expression	[20]
Nephrocystin-1 (NPHP1)	OTZHCFFQ	NPHP1_HUMAN	Increases Expression	[20]
Phosphatase and actin regulator 2 (PHACTR2)	OTWMX2A8	PHAR2_HUMAN	Increases Expression	[20]
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)	OT4TMERS	NFAC1_HUMAN	Increases Expression	[20]
Acyl-CoA 6-desaturase (FADS2)	OTUX531P	FADS2_HUMAN	Decreases Expression	[20]
Metalloproteinase inhibitor 1 (TIMP1)	OTOXC51H	TIMP1_HUMAN	Increases Expression	[20]
Cystatin-C (CST3)	OTNZ6AO4	CYTC_HUMAN	Increases Expression	[20]
Cystatin-S (CST4)	OTXXM8EH	CYTS_HUMAN	Increases Expression	[20]
Interstitial collagenase (MMP1)	OTI4I2V1	MMP1_HUMAN	Increases Expression	[20]
Integrin beta-1 (ITGB1)	OT6G1IAR	ITB1_HUMAN	Decreases Expression	[20]
Keratin, type II cytoskeletal 8 (KRT8)	OTTM4X11	K2C8_HUMAN	Increases Expression	[20]
Neurofilament light polypeptide (NEFL)	OTQESJV4	NFL_HUMAN	Increases Expression	[20]
Protein disulfide-isomerase (P4HB)	OTTYNYPF	PDIA1_HUMAN	Increases Expression	[20]
Decorin (DCN)	OTWLJL7K	PGS2_HUMAN	Decreases Expression	[20]
Profilin-1 (PFN1)	OTHTGA1H	PROF1_HUMAN	Increases Expression	[20]
Proto-oncogene tyrosine-protein kinase receptor Ret (RET)	OTLU040A	RET_HUMAN	Decreases Expression	[20]
Tropomyosin beta chain (TPM2)	OTA1L0P8	TPM2_HUMAN	Increases Expression	[20]
Transcription factor Sp1 (SP1)	OTISPT4X	SP1_HUMAN	Decreases Expression	[20]
Keratin, type I cytoskeletal 19 (KRT19)	OTDGDQ75	K1C19_HUMAN	Increases Expression	[20]
Insulin-like growth factor-binding protein 1 (IGFBP1)	OT6UQV2K	IBP1_HUMAN	Increases Expression	[20]
Small ribosomal subunit protein uS2 (RPSA)	OTJZHEGT	RSSA_HUMAN	Decreases Expression	[20]
Glycodelin (PAEP)	OTQA0NV4	PAEP_HUMAN	Decreases Expression	[20]
E3 SUMO-protein ligase EGR2 (EGR2)	OTAVQ78J	EGR2_HUMAN	Increases Expression	[20]
Pregnancy-specific beta-1-glycoprotein 1 (PSG1)	OT1U4ZZW	PSG1_HUMAN	Increases Expression	[20]
Collagen alpha-3(VI) chain (COL6A3)	OTAS6R6I	CO6A3_HUMAN	Decreases Expression	[20]
Parathyroid hormone-related protein (PTHLH)	OTI1JF13	PTHR_HUMAN	Decreases Expression	[20]
Plastin-3 (PLS3)	OTYBM4PK	PLST_HUMAN	Decreases Expression	[20]
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)	OT1LQSGX	MTDC_HUMAN	Decreases Expression	[20]
Pyruvate kinase PKM (PKM)	OTLHHMC2	KPYM_HUMAN	Increases Expression	[20]
Carboxypeptidase E (CPE)	OTXNTV79	CBPE_HUMAN	Increases Expression	[20]
High mobility group protein HMG-I/HMG-Y (HMGA1)	OTQUSHPX	HMGA1_HUMAN	Increases Expression	[20]
Gap junction alpha-1 protein (GJA1)	OTT94MKL	CXA1_HUMAN	Decreases Expression	[20]
Desmin (DES)	OTI09KBW	DESM_HUMAN	Increases Expression	[20]
Plasma membrane calcium-transporting ATPase 1 (ATP2B1)	OT5MXG9W	AT2B1_HUMAN	Decreases Expression	[20]
Cyclin-A2 (CCNA2)	OTPHHYZJ	CCNA2_HUMAN	Decreases Expression	[20]
5'-nucleotidase (NT5E)	OT7J5LT6	5NTD_HUMAN	Increases Expression	[20]
Fibroblast growth factor 7 (FGF7)	OTGK6ANL	FGF7_HUMAN	Decreases Expression	[20]
Insulin-like growth factor-binding protein 4 (IGFBP4)	OT2HZRBD	IBP4_HUMAN	Increases Expression	[20]
Transcription elongation factor A protein 1 (TCEA1)	OTBFO594	TCEA1_HUMAN	Decreases Expression	[20]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Increases Expression	[20]
Tenascin (TNC)	OTK4FSHR	TENA_HUMAN	Decreases Expression	[20]
V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C)	OTKPL09B	VATL_HUMAN	Increases Expression	[20]
Protein ITPRID2 (ITPRID2)	OTO3JDX5	ITPI2_HUMAN	Increases Expression	[20]
Dual specificity protein phosphatase 1 (DUSP1)	OTN6BR75	DUS1_HUMAN	Increases Expression	[20]
Interleukin-12 subunit beta (IL12B)	OT0JF8A3	IL12B_HUMAN	Increases Expression	[20]
Neurotensin/neuromedin N (NTS)	OTPGDNQS	NEUT_HUMAN	Decreases Expression	[20]
Guanylate-binding protein 2 (GBP2)	OTVU4G07	GBP2_HUMAN	Decreases Expression	[20]
MHC class II transactivator (CIITA)	OTRJNZFO	C2TA_HUMAN	Increases Expression	[20]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[20]
Exosome RNA helicase MTR4 (MTREX)	OTSQY30V	MTREX_HUMAN	Increases Expression	[20]
Alpha-S1-casein (CSN1S1)	OTXOW6XJ	CASA1_HUMAN	Increases Expression	[20]
Nuclear receptor-interacting protein 1 (NRIP1)	OTIZOJQV	NRIP1_HUMAN	Decreases Expression	[20]
Homeobox protein Hox-A1 (HOXA1)	OTMSOJ7D	HXA1_HUMAN	Increases Expression	[20]
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1)	OT6E2OW6	ENTP1_HUMAN	Increases Expression	[20]
Ephrin-A3 (EFNA3)	OTJGOUMZ	EFNA3_HUMAN	Increases Expression	[20]
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (ART1)	OT7FBG5W	NAR1_HUMAN	Increases Expression	[20]
Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1)	OTYHXLWZ	BCAT1_HUMAN	Decreases Expression	[20]
Microfibrillar-associated protein 2 (MFAP2)	OTMHVBTV	MFAP2_HUMAN	Decreases Expression	[20]
Laminin subunit beta-2 (LAMB2)	OT71OI2Y	LAMB2_HUMAN	Increases Expression	[20]
NHP2-like protein 1 (SNU13)	OTH56TIH	NH2L1_HUMAN	Increases Expression	[20]
Homeobox protein DLX-6 (DLX6)	OT0FIJHY	DLX6_HUMAN	Increases Expression	[20]
Neurotrypsin (PRSS12)	OT1MYL3L	NETR_HUMAN	Decreases Expression	[20]
Elongation factor 1-alpha 1 (EEF1A1)	OT00THXS	EF1A1_HUMAN	Decreases Expression	[20]
Microtubule-associated protein 1A (MAP1A)	OTHO8K43	MAP1A_HUMAN	Decreases Expression	[20]
E3 ubiquitin-protein ligase Mdm2 (MDM2)	OTOVXARF	MDM2_HUMAN	Increases Expression	[20]
Cytochrome c oxidase subunit 6A2, mitochondrial (COX6A2)	OTQR5SXD	CX6A2_HUMAN	Increases Expression	[20]
cAMP-responsive element modulator (CREM)	OTJIJ5AL	CREM_HUMAN	Decreases Expression	[20]
Caldesmon (CALD1)	OTNJKJ6Q	CALD1_HUMAN	Increases Expression	[20]
ATP-dependent RNA helicase A (DHX9)	OT5AAOQI	DHX9_HUMAN	Decreases Expression	[20]
Serine/threonine-protein kinase PAK 1 (PAK1)	OT17LZNZ	PAK1_HUMAN	Increases Expression	[20]
Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5)	OT6T408U	MP2K5_HUMAN	Decreases Expression	[20]
Chitotriosidase-1 (CHIT1)	OTPQR0A6	CHIT1_HUMAN	Increases Expression	[20]
Ras and Rab interactor 1 (RIN1)	OTPBROUD	RIN1_HUMAN	Increases Expression	[20]
Keratin, type I cuticular Ha2 (KRT32)	OTZCGZYT	K1H2_HUMAN	Increases Expression	[20]
Semaphorin-3A (SEMA3A)	OTQJSV7W	SEM3A_HUMAN	Increases Expression	[20]
Ras GTPase-activating protein 3 (RASA3)	OT9C54MN	RASA3_HUMAN	Increases Expression	[20]
Mediator of DNA damage checkpoint protein 1 (MDC1)	OTEUQH4J	MDC1_HUMAN	Increases Expression	[20]
Transmembrane glycoprotein NMB (GPNMB)	OTB7KQKV	GPNMB_HUMAN	Decreases Expression	[20]
Mortality factor 4-like protein 2 (MORF4L2)	OT8OI3EC	MO4L2_HUMAN	Decreases Expression	[20]
kinase isozyme 1, mitochondrial (PDK1)	OTMABK9Z	PDK1_HUMAN	Increases Expression	[20]
Serine/threonine-protein kinase 38 (STK38)	OTKMYCYR	STK38_HUMAN	Decreases Expression	[20]
Serine/threonine-protein phosphatase 2A activator (PTPA)	OTRGFOI7	PTPA_HUMAN	Increases Expression	[20]
Reticulocalbin-1 (RCN1)	OT3JBGAG	RCN1_HUMAN	Decreases Expression	[20]
Olfactory receptor 8B8 (OR8B8)	OTCISNYV	OR8B8_HUMAN	Increases Expression	[20]
Leukotriene B4 receptor 1 (LTB4R)	OT3SRH4H	LT4R1_HUMAN	Decreases Expression	[20]
Serine/arginine-rich splicing factor 7 (SRSF7)	OTRS4W4S	SRSF7_HUMAN	Decreases Expression	[20]
Guanylate kinase (GUK1)	OTLI0HRU	KGUA_HUMAN	Increases Expression	[20]
Filamin A-interacting protein 1-like (FILIP1L)	OTPY8IMS	FIL1L_HUMAN	Decreases Expression	[20]
Nucleolar MIF4G domain-containing protein 1 (NOM1)	OTWZSJJC	NOM1_HUMAN	Decreases Expression	[20]
Opioid growth factor receptor-like protein 1 (OGFRL1)	OT6QGBYE	OGRL1_HUMAN	Increases Expression	[20]
Serine/threonine-protein kinase MRCK alpha (CDC42BPA)	OTCPFOSA	MRCKA_HUMAN	Decreases Expression	[20]
Extracellular sulfatase Sulf-1 (SULF1)	OTJCNCO0	SULF1_HUMAN	Decreases Expression	[20]
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2)	OTRUIMC4	GNT2A_HUMAN	Decreases Expression	[20]
Oxidation resistance protein 1 (OXR1)	OTPIDMT3	OXR1_HUMAN	Increases Expression	[20]
Alpha-2,8-sialyltransferase 8B (ST8SIA2)	OTRBBBD8	SIA8B_HUMAN	Decreases Expression	[20]
Type II iodothyronine deiodinase (DIO2)	OTGPNSLH	IOD2_HUMAN	Decreases Expression	[20]
G-patch domain and KOW motifs-containing protein (GPKOW)	OTGS3H0M	GPKOW_HUMAN	Increases Expression	[20]
Rho guanine nucleotide exchange factor 2 (ARHGEF2)	OTBQTFRT	ARHG2_HUMAN	Decreases Expression	[20]
Homogentisate 1,2-dioxygenase (HGD)	OTTKLQOO	HGD_HUMAN	Increases Expression	[20]
Secretory carrier-associated membrane protein 4 (SCAMP4)	OTSCZTJ5	SCAM4_HUMAN	Increases Expression	[20]
Protein bicaudal D homolog 1 (BICD1)	OT78IYPF	BICD1_HUMAN	Decreases Expression	[20]
Ankyrin repeat and SOCS box protein 2 (ASB2)	OTF9LV7L	ASB2_HUMAN	Increases Expression	[20]
Eyes absent homolog 1 (EYA1)	OTHU807A	EYA1_HUMAN	Decreases Expression	[20]
Bcl-2-like protein 13 (BCL2L13)	OT2VRFTM	B2L13_HUMAN	Increases Expression	[20]
RNA helicase Mov10l1 (MOV10L1)	OTP978LK	M10L1_HUMAN	Increases Expression	[20]
Rac GTPase-activating protein 1 (RACGAP1)	OTQE8IEH	RGAP1_HUMAN	Increases Expression	[20]
Ras-related protein Rab-1B (RAB1B)	OTAFCUAS	RAB1B_HUMAN	Increases Expression	[20]
Semaphorin-6C (SEMA6C)	OT1N59T5	SEM6C_HUMAN	Increases Expression	[20]
Sentrin-specific protease 3 (SENP3)	OTFQDOMC	SENP3_HUMAN	Increases Expression	[20]
Ribonuclease P protein subunit p21 (RPP21)	OT53MDNE	RPP21_HUMAN	Increases Expression	[20]
Protocadherin-18 (PCDH18)	OTTLQWRN	PCD18_HUMAN	Decreases Expression	[20]
Protein S100-A14 (S100A14)	OTVFJJ91	S10AE_HUMAN	Decreases Expression	[20]
Tryptase gamma (TPSG1)	OTDESHKT	TRYG1_HUMAN	Decreases Expression	[20]
Rho GTPase-activating protein 35 (ARHGAP35)	OTJ8POG0	RHG35_HUMAN	Increases Expression	[20]
Neuroligin-3 (NLGN3)	OTKDEC1Q	NLGN3_HUMAN	Increases Expression	[20]
Polycystin-2-like protein 1 (PKD2L1)	OT1KJDAT	PK2L1_HUMAN	Increases Expression	[20]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)	OTTLJH8W	ATS1_HUMAN	Decreases Expression	[20]
Cytoplasmic phosphatidylinositol transfer protein 1 (PITPNC1)	OT64TTGC	PITC1_HUMAN	Decreases Expression	[20]
Transcription factor SOX-13 (SOX13)	OTCIF6KC	SOX13_HUMAN	Decreases Expression	[20]
Afadin- and alpha-actinin-binding protein (SSX2IP)	OTEIZ7N1	ADIP_HUMAN	Increases Expression	[20]
Transmembrane emp24 domain-containing protein 3 (TMED3)	OTNOPHHC	TMED3_HUMAN	Increases Expression	[20]
Protocadherin beta-4 (PCDHB4)	OTF665E0	PCDB4_HUMAN	Decreases Expression	[20]
Protocadherin beta-14 (PCDHB14)	OTFZF1ST	PCDBE_HUMAN	Decreases Expression	[20]
Adenylate kinase isoenzyme 5 (AK5)	OTTGXLOT	KAD5_HUMAN	Increases Expression	[20]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Increases Expression	[28]
Alpha-fetoprotein (AFP)	OT9GG3ZI	FETA_HUMAN	Increases Expression	[28]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Increases Expression	[28]
Tyrosine aminotransferase (TAT)	OT2CJ91O	ATTY_HUMAN	Increases Expression	[28]
Hepatocyte nuclear factor 4-alpha (HNF4A)	OTY1TOAB	HNF4A_HUMAN	Increases Expression	[28]
CCAAT/enhancer-binding protein alpha (CEBPA)	OTOM9OE4	CEBPA_HUMAN	Increases Expression	[28]
Hematopoietically-expressed homeobox protein HHEX (HHEX)	OTLIUVYX	HHEX_HUMAN	Increases Expression	[28]
Suppressor of cytokine signaling 3 (SOCS3)	OTY183WJ	SOCS3_HUMAN	Affects Expression	[26]
Telomerase reverse transcriptase (TERT)	OT085VVA	TERT_HUMAN	Decreases Expression	[29]
Aquaporin-9 (AQP9)	OTLGH5ZY	AQP9_HUMAN	Increases Expression	[30]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 (GNG7)	OTHS1L0E	GBG7_HUMAN	Affects Methylation	[31]
Claudin-7 (CLDN7)	OTNE0XHQ	CLD7_HUMAN	Decreases Expression	[32]
Claudin-9 (CLDN9)	OTCKI2IZ	CLD9_HUMAN	Increases Expression	[33]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[29]
Calcitonin (CALCA)	OTZ11LHB	CALC_HUMAN	Decreases Methylation	[34]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Increases Response To Substance	[35]
Estrogen receptor (ESR1)	OTKLU61J	ESR1_HUMAN	Increases Expression	[36]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Affects Activity	[37]
Interleukin-4 (IL4)	OTOXBWAU	IL4_HUMAN	Affects Methylation	[38]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Affects Methylation	[38]
Tyrosine-protein kinase Fyn (FYN)	OTLSLVZS	FYN_HUMAN	Increases Expression	[39]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Increases Expression	[40]
L-lactate dehydrogenase B chain (LDHB)	OT9B1CT3	LDHB_HUMAN	Increases Expression	[41]
Thyroid peroxidase (TPO)	OTJJLL20	PERT_HUMAN	Increases Expression	[42]
Prostate-specific antigen (KLK3)	OTFGSBFJ	KLK3_HUMAN	Increases Expression	[40]
Histone H1.0 (H1-0)	OTRLJK4Z	H10_HUMAN	Increases Expression	[43]
Interleukin-6 receptor subunit alpha (IL6R)	OTCQL07Z	IL6RA_HUMAN	Affects Expression	[26]
Gamma-enolase (ENO2)	OTRODL0T	ENOG_HUMAN	Decreases Expression	[44]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Increases Expression	[40]
Microtubule-associated protein tau (MAPT)	OTMTP2Z7	TAU_HUMAN	Decreases Expression	[45]
Chromogranin-A (CHGA)	OTXYX5JH	CMGA_HUMAN	Decreases Expression	[44]
Cyclin-dependent kinase 4 (CDK4)	OT7EP05T	CDK4_HUMAN	Decreases Expression	[40]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Increases Expression	[46]
G2/mitotic-specific cyclin-B1 (CCNB1)	OT19S7E5	CCNB1_HUMAN	Increases Expression	[44]
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Decreases Methylation	[47]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Expression	[48]
Methylated-DNA--protein-cysteine methyltransferase (MGMT)	OT40A9WH	MGMT_HUMAN	Increases Expression	[49]
Thyrotropin receptor (TSHR)	OT0BC8LB	TSHR_HUMAN	Increases Expression	[42]
Hepatocyte nuclear factor 1-alpha (HNF1A)	OT9DOUKL	HNF1A_HUMAN	Increases Expression	[30]
Fibulin-1 (FBLN1)	OT5MHHOP	FBLN1_HUMAN	Increases Expression	[39]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)	OTDRV63V	GA45A_HUMAN	Increases Expression	[50]
Cyclin-dependent kinase 2 (CDK2)	OTB5DYYZ	CDK2_HUMAN	Decreases Expression	[40]
DNA cytosine-5)-methyltransferase 1 (DNMT1)	OTM2DGTK	DNMT1_HUMAN	Decreases Expression	[51]
G1/S-specific cyclin-D2 (CCND2)	OTDULQF9	CCND2_HUMAN	Affects Methylation	[52]
Oxytocin receptor (OXTR)	OT7WFW4U	OXYR_HUMAN	Decreases Expression	[39]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Affects Expression	[26]
Cyclin-dependent kinase inhibitor 2A (CDKN2A)	OTN0ZWAE	CDN2A_HUMAN	Decreases Methylation	[53]
Melanoma-associated antigen 1 (MAGEA1)	OTXAO193	MAGA1_HUMAN	Decreases Methylation	[53]
Melanoma-associated antigen 3 (MAGEA3)	OTW3Y5M4	MAGA3_HUMAN	Increases Expression	[54]
Killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1)	OTL1LBQJ	KI2L1_HUMAN	Increases Expression	[55]
Killer cell immunoglobulin-like receptor 2DL2 (KIR2DL2)	OTOVUTJD	KI2L2_HUMAN	Increases Expression	[55]
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3)	OTFCN53B	KI2L3_HUMAN	Increases Expression	[55]
Killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1)	OTPOSXFX	KI3L1_HUMAN	Increases Expression	[55]
Killer cell immunoglobulin-like receptor 2DS4 (KIR2DS4)	OT00N6UJ	KI2S4_HUMAN	Increases Expression	[55]
Tumor necrosis factor ligand superfamily member 6 (FASLG)	OTZARCHH	TNFL6_HUMAN	Increases Response To Substance	[35]
Stromal cell-derived factor 1 (CXCL12)	OT2QX5LL	SDF1_HUMAN	Increases Expression	[56]
Tuberin (TSC2)	OT47LWI9	TSC2_HUMAN	Increases Expression	[57]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)	OT4PXBTA	TNF10_HUMAN	Increases Response To Substance	[35]
High mobility group protein HMGI-C (HMGA2)	OTBMBHHL	HMGA2_HUMAN	Increases Expression	[39]
Homeobox protein Nkx-2.5 (NKX2-5)	OTS1SAWM	NKX25_HUMAN	Increases Expression	[58]
Death-associated protein kinase 1 (DAPK1)	OTNCNUCO	DAPK1_HUMAN	Affects Methylation	[59]
Claudin-6 (CLDN6)	OTEN8ID2	CLD6_HUMAN	Increases Expression	[33]
Claudin-8 (CLDN8)	OT7IIWXG	CLD8_HUMAN	Increases Expression	[33]
Small ribosomal subunit protein eS6 (RPS6)	OTT4D1LN	RS6_HUMAN	Decreases Phosphorylation	[39]
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)	OT83PT85	PP2AA_HUMAN	Increases Expression	[60]
Cyclin-A1 (CCNA1)	OTX4HD45	CCNA1_HUMAN	Decreases Expression	[61]
Heat shock factor protein 1 (HSF1)	OTYNJ4KP	HSF1_HUMAN	Decreases Activity	[62]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Affects Localization	[26]
Tight junction protein ZO-1 (TJP1)	OTBDCUPK	ZO1_HUMAN	Increases Expression	[33]
Dihydropyrimidine dehydrogenase (DPYD)	OTWRF2NR	DPYD_HUMAN	Decreases Methylation	[63]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)	OT4SO7J4	BNIP3_HUMAN	Increases Expression	[64]
N-myc-interactor (NMI)	OTYVG3NM	NMI_HUMAN	Increases Expression	[39]
NAD(P) transhydrogenase, mitochondrial (NNT)	OTAIOGZK	NNTM_HUMAN	Increases Expression	[32]
Runt-related transcription factor 3 (RUNX3)	OTITK1XD	RUNX3_HUMAN	Affects Methylation	[65]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Expression	[66]
Cyclin-G2 (CCNG2)	OTII38K2	CCNG2_HUMAN	Decreases Expression	[39]
Occludin (OCLN)	OTSUTVWL	OCLN_HUMAN	Increases Expression	[33]
kinase isozyme 4, mitochondrial (PDK4)	OTCMHMBZ	PDK4_HUMAN	Decreases Methylation	[67]
Dual specificity protein phosphatase 6 (DUSP6)	OT4H6RKW	DUS6_HUMAN	Increases Expression	[39]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)	OTE8GBUR	RIR2B_HUMAN	Increases Expression	[68]
Sodium/iodide cotransporter (SLC5A5)	OTU7E9G7	SC5A5_HUMAN	Increases Expression	[69]
Krueppel-like factor 6 (KLF6)	OTQY9S7F	KLF6_HUMAN	Increases Expression	[39]
Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4)	OTXN18OA	KI2L4_HUMAN	Increases Expression	[55]
Protein Niban 1 (NIBAN1)	OTYOLI12	NIBA1_HUMAN	Increases Expression	[39]
Calcium homeostasis modulator protein 2 (CALHM2)	OTWWM6HI	CAHM2_HUMAN	Increases Expression	[32]
Homeobox protein SIX2 (SIX2)	OTYOVGSC	SIX2_HUMAN	Decreases Expression	[32]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)	OT9HYT7A	PLCB1_HUMAN	Increases Expression	[70]
Sal-like protein 4 (SALL4)	OTC08PR5	SALL4_HUMAN	Affects Methylation	[22]
Transcription factor MafB (MAFB)	OTH2N3T8	MAFB_HUMAN	Increases Expression	[32]
Sodium/nucleoside cotransporter 1 (SLC28A1)	OTXWVV9O	S28A1_HUMAN	Increases Response To Substance	[71]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Myelodysplastic Syndromes	DCIEAN8	N. A.	Phase 3	[2]

References

• [1] ClinicalTrials.gov (NCT02807558) A Biomarker-Directed Phase 2 Trial of Tamibarotene (SY-1425) in Participants With Acute Myeloid Leukemia or Myelodysplastic Syndrome
• [2] ClinicalTrials.gov (NCT04797780) SY-1425 Plus Azacitidine in Participants With Newly Diagnosed RARA-positive Higher-Risk Myelodysplastic Syndrome. U.S. National Institutes of Health.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2648).
• [4] Azacitidine FDA Label
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6796).
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• [13] Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and?mortality. EMBO Mol Med. 2016 Nov 2;8(11):1340-1359. doi: 10.15252/emmm.201606434. Print 2016 Nov.
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• [15] Thyroid hormone regulation of apoptosis induced by retinoic acid in promyeloleukemic HL-60 cells: studies with retinoic acid receptor-specific and retinoid x receptor-specific ligands. Thyroid. 2000 Dec;10(12):1023-34. doi: 10.1089/thy.2000.10.1023.
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