Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9OZWQ)

• Drug Name: Lovastatin Drug Info
• Synonyms: lovastatin; 75330-75-5; mevinolin; Mevacor; Lovalip; Monacolin K; Lovalord; Mevinacor; Altoprev; Nergadan; Artein; Altocor; 6alpha-Methylcompactin; MK-803; Hipovastin; Lovastatine; Lovasterol; Paschol; Lipivas; Closterol; Teroltrat; Tecnolip; Rovacor; Cholestra; Rodatin; Lozutin; Lipofren; Lestatin; Hipolip; Colevix; Sivlor; Taucor; Lipdip; Belvas; Mevlor; Lovastatine [French]; Lovastatinum [Latin]; Lovastatina [Spanish]; 6-alpha-Methylcompactin; Lovastatinum; Lovastatina; Lovastin; MSD 803; MK 803; 6 alpha-Methylcompactin; UNII-9LHU78OQFD; Altocor; Liposcler; Mevinolin; Rextat; Sivlor;Taucor; Monakolin K; MK803; Advicor (TN); Altocor (TN); Altoprev (TN); L-154803; Lovastatin & Primycin; ML-530B; Mevacor (TN); Mevinolin from Aspergillus sp; Statosan (TN); Lovastatin (USP/INN); Lovastatin [USAN:BAN:INN]; Lovastatin, (1 alpha(S*))-Isomer; Lovastatin, 1 alpha-Isomer (without R*/S* notation); 2beta,6alpha-Dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone; 6 Methylcompactin; 6-Methylcompactin; Aspirin/lisinopril/ lovastatin fixed-dose combination

Indication

Disease Entry	ICD 11	Status	REF
Arteriosclerosis	BD40	Approved	[1]
Hypercholesterolaemia	5C80.0	Approved	[2]
Hyperlipidemia	5C80.Z	Approved	[1]
Hyperlipidemia, familial combined, LPL related		Approved	[1]
Hypertriglyceridemia	5C80.1	Approved	[1]
Melanoma	2C30	Approved	[1]
X-linked chondrodysplasia punctata 2		Approved	[1]
Cardiovascular disease	BA00-BE2Z	Phase 3	[3]
Smith-Lemli-Opitz syndrome		Investigative	[1]

• Therapeutic Class: Anticholesteremic Agents
• Cross-matching ID:
  PubChem CID: 53232
  ChEBI ID: CHEBI:40303
  CAS Number: CAS 75330-75-5
  TTD Drug ID: DM9OZWQ
  VARIDT Drug ID: DR00410
  INTEDE Drug ID: DR0986
  ACDINA Drug ID: D00377

Molecule-Related Drug Atlas

Drug(s) Targeting HMG-CoA reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[18]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[19]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[20]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[21]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[22]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[19]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[23]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[19]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[23]
TOCOTRIENOL	DM1UE67	Hyperlipidaemia	5C80	Approved	[24]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[25]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[27]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[6]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[6]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[28]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[6]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[29]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[30]

Drug(s) Transported By Organic anion transporting polypeptide 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[32]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[34]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[33]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[35]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[36]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[37]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[38]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[35]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[39]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[40]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[41]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[45]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[40]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[47]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[90]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[91]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[92]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[93]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[94]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[95]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[96]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[97]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[98]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[48]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[50]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[51]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[54]
Metronidazole	DMTIVEN	Abscess		Approved	[55]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[56]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[57]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[58]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[59]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[59]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[60]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[61]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[62]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[63]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[59]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[64]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[65]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[84]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[85]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[85]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[86]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[84]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[84]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[84]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[87]
Dabrafenib	DMX6OE3	Melanoma	2C30	Approved	[88]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]

Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[66]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[67]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[69]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[60]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[70]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[73]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[65]

Drug(s) Metabolized By UDP-glucuronosyltransferase 2B7 (UGT2B7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[74]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[75]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[64]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[47]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[79]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[8]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A3 (UGT1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[47]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[81]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[82]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[83]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[8]
Losartan	DM72JXH	Diabetic kidney disease	GB61.Z	Approved	[47]

Drug(s) Affected By Serum paraoxonase/lactonase 3 (PON3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[102]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[103]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[104]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[105]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[105]
Phenylacetic acid	DMQ95GE	Hepatic encephalopathy	DB99.5	Approved	[106]
RTR-003632	DM45NHF	N. A.	N. A.	Phase 2	[107]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[108]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[109]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[111]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[112]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[113]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[113]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[114]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[115]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[116]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[117]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[118]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[119]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[120]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[121]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[122]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[123]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[124]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[125]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[123]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[126]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[127]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[14]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[131]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[135]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[137]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[138]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[139]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[141]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[142]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[143]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[144]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[145]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[147]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[148]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[150]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[151]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[152]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[153]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[154]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[156]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[157]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[158]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[150]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[152]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[161]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[162]

Drug(s) Affected By Squalene synthase (FDFT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[163]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[167]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[168]

Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[169]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[170]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[171]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[172]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[174]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[175]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[176]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[178]

Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[131]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[181]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[180]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[182]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[184]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[185]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[186]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[131]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[187]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[190]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[192]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[193]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[193]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[109]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[192]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[193]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[194]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[192]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[195]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[192]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[196]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[197]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[198]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[150]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[199]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[200]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[201]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[203]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[205]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[208]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[209]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[210]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[212]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[213]

Drug(s) Affected By GTPase NRas (NRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[214]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[215]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[216]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[167]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[218]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[219]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[220]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[221]

Drug(s) Affected By GTPase HRas (HRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[223]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[214]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[224]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[215]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[217]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[225]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]

Drug(s) Affected By GTPase KRas (KRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[226]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[227]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Tiazofurin	DM5JWV9	Solid tumour/cancer	2A00-2F9Z	Approved	[228]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[229]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[230]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[231]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[225]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[167]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[233]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[233]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[234]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]

Drug(s) Affected By Thyroglobulin (TG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[235]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[236]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[183]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[237]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[238]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]

Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[11]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[242]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[243]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[244]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[245]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[246]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[247]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[216]

Drug(s) Affected By Apolipoprotein B-100 (APOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[248]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[103]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[248]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[248]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[250]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[248]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[251]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[252]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[161]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[253]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[137]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[255]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[256]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[144]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[257]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[258]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[161]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[260]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[261]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[262]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[263]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[264]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[243]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[265]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[266]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[267]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[268]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[269]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[206]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[270]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[271]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[272]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[273]

Drug(s) Affected By Tyrosine 3-monooxygenase (TH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zonisamide	DM0DTF7	Alcohol dependence	6C40.2	Approved	[274]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[275]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[277]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[278]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[279]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[280]
Methamphetamine	DMPM4SK	Anxiety		Approved	[281]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[282]
Piperazine	DMTY9LU	Ascariasis	1F62	Approved	[283]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Selenium	DM25CGV	N. A.	N. A.	Approved	[285]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[286]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[287]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[288]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[289]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[290]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[291]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[292]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[293]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[294]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[295]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[296]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[297]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[298]
Selenium	DM25CGV	N. A.	N. A.	Approved	[299]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[300]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[301]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[302]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[303]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[304]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[150]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[305]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[306]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[305]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[307]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[154]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[308]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[309]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[310]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[311]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[312]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[14]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[313]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[147]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[314]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[315]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[316]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[317]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[318]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[319]
Selenium	DM25CGV	N. A.	N. A.	Approved	[285]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[320]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[307]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[321]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[322]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[323]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[157]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[324]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[103]
Selenium	DM25CGV	N. A.	N. A.	Approved	[325]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[326]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[328]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[329]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[210]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[330]

Drug(s) Affected By Neuromodulin (GAP43)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[331]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[331]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[276]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[210]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[332]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[331]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[333]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[334]
Megestrol	DMDH9KX	Breast cancer	2C60-2C65	Approved	[331]
Scopolamine	DMOM8AL	Addictive disorder	6C50-6C5Z	Approved	[335]

Drug(s) Affected By Lamin-B1 (LMNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[336]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[337]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[162]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[338]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[328]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[339]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[183]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[165]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[340]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[341]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[315]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[342]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[343]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[269]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[344]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[345]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[346]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[348]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[349]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[350]
Selenium	DM25CGV	N. A.	N. A.	Approved	[351]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[306]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[352]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[321]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[353]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[273]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[354]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[355]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[356]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[314]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[357]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[358]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[359]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[360]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[361]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[362]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[363]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[355]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[364]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[365]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[366]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[354]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[14]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[157]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[314]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[357]

Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[343]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[273]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[367]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[368]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[369]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[370]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[243]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[371]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[372]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[373]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[374]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[144]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[315]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[375]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[376]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[377]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[129]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[345]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[378]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[379]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[380]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[381]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[382]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[383]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[384]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[317]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[385]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[386]

Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[261]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[14]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[387]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[388]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[389]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[390]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[381]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[391]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[392]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[393]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[394]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[395]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[396]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[397]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[398]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[399]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[400]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[401]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[402]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[197]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[269]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[199]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[403]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[306]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[404]

Drug(s) Affected By Caspase-2 (CASP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[405]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[406]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[407]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[408]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[409]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[372]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[217]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[267]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[343]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[403]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[410]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[411]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[412]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[413]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[414]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[415]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[417]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[129]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[248]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[16]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[418]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[419]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[339]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[181]

Drug(s) Affected By Centromere protein F (CENPF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[103]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[337]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[183]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[420]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[268]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[421]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[422]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[423]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[424]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[425]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[426]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[427]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[387]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[428]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[429]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[321]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[430]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[431]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[432]

Drug(s) Affected By Caspase-6 (CASP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[238]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[103]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[433]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[434]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[435]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[436]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[437]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[144]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[438]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[439]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[161]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[440]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[227]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[441]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[442]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[213]

Drug(s) Affected By Cell division control protein 42 homolog (CDC42)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[243]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[371]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[443]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[444]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[167]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[445]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[446]
Bortezomib	DMNO38U	Leukemia		Approved	[447]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[448]

Drug(s) Affected By Transforming protein RhoA (RHOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[302]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[449]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[450]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[339]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[339]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[451]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[452]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[453]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[454]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[455]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[456]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[457]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[458]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[372]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[459]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[183]

Drug(s) Affected By Rho-related GTP-binding protein RhoB (RHOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[339]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[339]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[210]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[460]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[443]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[461]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[444]

Drug(s) Affected By Ras-related protein Rap-1A (RAP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[462]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[463]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[464]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[465]
Minodronate	DM50PMY	Osteoporosis	FB83.0	Approved	[466]
Risedronate	DM5FLTY	Bone Paget disease		Approved	[467]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[217]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[467]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[334]

Drug(s) Affected By Ras-related C3 botulinum toxin substrate 1 (RAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[468]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[11]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[460]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[371]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[469]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[167]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[470]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[471]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[472]

Drug(s) Affected By HLA class II histocompatibility antigen, DR beta 3 chain (HLA-DRB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[473]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[474]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[309]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[143]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[313]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[387]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[148]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[269]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[475]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[306]

Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[14]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[476]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[181]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[372]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[477]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[217]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[16]

Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[478]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[479]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[480]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[481]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[481]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[482]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[483]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[484]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[485]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[481]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[486]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[487]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[488]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[489]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[490]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[491]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[492]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[493]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[295]

Drug(s) Affected By Lymphoid enhancer-binding factor 1 (LEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[494]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[495]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[496]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[497]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[498]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[499]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[500]
Thymoquinone	DMVDTR2	Polycystic ovarian syndrome	5A80.1	Phase 2/3	[501]

Drug(s) Affected By A-kinase anchor protein 7 isoforms alpha and beta (AKAP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[103]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[406]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[277]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[444]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[502]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[219]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[503]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[503]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[504]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[505]

Drug(s) Affected By Beta-parvin (PARVB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[218]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
Bevacizumab	DMSD1UN	Adenocarcinoma	2D40	Approved	[506]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[500]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[507]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[438]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[508]

Drug(s) Affected By Metalloreductase STEAP2 (STEAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[438]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[509]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[510]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[218]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[219]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[238]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[511]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[498]

Drug(s) Affected By Interleukin-2 (IL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[14]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[512]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[513]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[514]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[515]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[516]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[517]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[518]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[519]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[520]

Drug(s) Affected By Alanine aminotransferase 1 (GPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[14]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[521]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[522]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[14]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[14]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[14]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[523]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[524]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[523]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[523]

Drug(s) Affected By Phosphatidate phosphatase LPIN2 (LPIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[438]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[525]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[178]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[498]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[278]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[526]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[527]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[528]

Drug(s) Affected By ELL-associated factor 2 (EAF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[529]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[530]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[333]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[444]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[529]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[531]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[532]

Drug(s) Affected By Ankyrin-2 (ANK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[387]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[394]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[444]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[167]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[502]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[533]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[533]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HMG-CoA reductase (HMGCR)	TTPADOQ	HMDH_HUMAN	Inhibitor	[4]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[5]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[6]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[7]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Substrate	[8]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[8]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[8]
UDP-glucuronosyltransferase 2B7 (UGT2B7)	DEB3CV1	UD2B7_HUMAN	Substrate	[8]
UDP-glucuronosyltransferase 1A3 (UGT1A3)	DEF2WXN	UD13_HUMAN	Substrate	[8]
Serum paraoxonase/lactonase 3 (PON3)	DETXQZ1	PON3_HUMAN	Substrate	[9]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[10]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[11]
A-kinase anchor protein 7 isoforms alpha and beta (AKAP7)	OT0L3PZ6	AKA7A_HUMAN	Drug Response	[12]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[13]
Alanine aminotransferase 1 (GPT)	OTOXOA0Q	ALAT1_HUMAN	Drug Response	[14]
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Protein Interaction/Cellular Processes	[15]
Ankyrin-2 (ANK2)	OTWB4R1Y	ANK2_HUMAN	Drug Response	[12]
Apolipoprotein B-100 (APOB)	OTH0UOCZ	APOB_HUMAN	Protein Interaction/Cellular Processes	[16]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[17]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[17]

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