Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7U58J)

• Drug Name: Isoflavone Drug Info
• Synonyms: Isoflavone; Isoflavone (8CI); Isoflavone skeleton; LS-191186; MCULE-2586547916; OVO2KUW8H8; SBB068618; SCHEMBL8028; ST098957; VN10014; ZINC895390; isoflavon; 3-Phenylchromone; 3-phenyl-4H-1-benzopyran-4-one; 3-phenyl-4H-chromen-4-one; 3-phenylchromen-4-one; 4H-1-Benzopyran-4-one, 3-phenyl-; 574-12-9; AC-12802; AK114020; AKOS015918505; AX8135136; BCP22856; BCP9000133; CCG-214095; CHEBI:18220; CHEMBL366460; CS-W006405; DB12007; DS-6374; DTXSID90205986; KS-00000GFW; NSC 135405; NSC-135405; NSC135405; GOMNOOKGLZYEJT-UHFFFAOYSA-N; UNII-OVO2KUW8H8
• Cross-matching ID:
  PubChem CID: 72304
  ChEBI ID: CHEBI:18220
  CAS Number: CAS 574-12-9
  TTD Drug ID: DM7U58J
  INTEDE Drug ID: DR2435

Molecule-Related Drug Atlas

Drug(s) Metabolized By Biphenyl dioxygenase (bphC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AUS-131	DMUXO3Z	Hot flushes	GA30	Phase 2	[1]
flavone	DMEQH6J	Discovery agent	N.A.	Investigative	[1]
Flavanone	DMNWIYM	Discovery agent	N.A.	Investigative	[1]

Drug(s) Metabolized By Naphthalene dioxygenase (doxB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
flavone	DMEQH6J	Discovery agent	N.A.	Investigative	[1]

Drug(s) Affected By Steroid hormone receptor ERR1 (ESRRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[5]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[7]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Bortezomib	DMNO38U	Leukemia		Approved	[10]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[11]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[12]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[12]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[13]

Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[15]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[16]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[18]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[19]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[20]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[21]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[22]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[22]

Drug(s) Affected By Phospholipid phosphatase 3 (PLPP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Selenium	DM25CGV	N. A.	N. A.	Approved	[24]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[25]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]

Drug(s) Affected By Glutathione S-transferase 3, mitochondrial (MGST3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[39]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[40]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[41]

Drug(s) Affected By Maleylacetoacetate isomerase (GSTZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[48]

Drug(s) Affected By DnaJ homolog subfamily B member 6 (DNAJB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[49]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[50]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[53]

Drug(s) Affected By Delta(14)-sterol reductase TM7SF2 (TM7SF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[55]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[23]

Drug(s) Affected By Fatty acid CoA ligase Acsl3 (ACSL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[58]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[55]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[61]

Drug(s) Affected By Coagulation factor XII (F12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[33]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[62]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[65]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[68]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[70]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[75]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[77]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[80]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[81]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]

Drug(s) Affected By Fibronectin (FN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[84]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[85]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[90]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]

Drug(s) Affected By Histone H2A type 1-B/E (H2AC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[92]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[95]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[97]

Drug(s) Affected By Integrin beta-2 (ITGB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[56]

Drug(s) Affected By Inhibin beta A chain (INHBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[108]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[40]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[109]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[110]

Drug(s) Affected By SPARC (SPARC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[112]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[113]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[114]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[115]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[116]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[117]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[118]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[119]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[120]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[122]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[125]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[123]

Drug(s) Affected By Collagen alpha-3(VI) chain (COL6A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[39]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[40]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[128]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[129]

Drug(s) Affected By Leukemia inhibitory factor (LIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[92]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[132]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[133]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]

Drug(s) Affected By 15-hydroxyprostaglandin dehydrogenase (HPGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[135]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[135]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[136]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[137]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[139]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[140]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[141]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[134]

Drug(s) Affected By Histone H1.2 (H1-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[136]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[95]

Drug(s) Affected By Transcription factor JunB (JUNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[144]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[133]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[146]

Drug(s) Affected By Insulin-like growth factor-binding protein 3 (IGFBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[147]
Selenium	DM25CGV	N. A.	N. A.	Approved	[148]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[149]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[151]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[153]

Drug(s) Affected By Follistatin (FST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[122]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[155]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[39]

Drug(s) Affected By Insulin-like growth factor-binding protein 5 (IGFBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[144]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[156]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[157]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[158]

Drug(s) Affected By Pentraxin-related protein PTX3 (PTX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[95]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[161]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[96]
Bortezomib	DMNO38U	Leukemia		Approved	[162]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Dipeptidyl peptidase 4 (DPP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Saxagliptin	DMGXENV	Type-2 diabetes	5A11	Approved	[163]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Alogliptin	DM8WI3R	Type-2 diabetes	5A11	Approved	[165]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[167]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[161]

Drug(s) Affected By Neurotensin receptor type 1 (NTSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[65]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[169]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[170]
NEUROTENSIN	DM27WCE	Discovery agent	N.A.	Investigative	[171]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[172]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[173]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[174]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[175]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[176]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[178]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[179]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[180]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[181]

Drug(s) Affected By Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[183]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[97]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[184]

Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[185]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[186]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[185]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[187]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[188]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[189]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[186]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[191]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[192]

Drug(s) Affected By Retinaldehyde dehydrogenase 3 (ALDH1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[75]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[193]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[133]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[136]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[136]

Drug(s) Affected By CCN family member 3 (CCN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[39]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[41]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[195]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[196]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[194]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[197]

Drug(s) Affected By Paxillin (PXN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[200]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[201]
Terbinafine	DMI6HUW	Fungal infection	1F29-1F2F	Approved	[202]

Drug(s) Affected By NPC intracellular cholesterol transporter 2 (NPC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[63]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[204]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[100]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[205]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[206]

Drug(s) Affected By Histone H3.1 (H3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[208]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]

Drug(s) Affected By Aldehyde oxidase (AOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[134]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[25]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[210]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[161]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[39]

Drug(s) Affected By Alpha-globin transcription factor CP2 (TFCP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[211]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[19]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[212]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[213]
geraniol	DMS3CBD	Discovery agent	N.A.	Investigative	[214]

Drug(s) Affected By Squalene monooxygenase (SQLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[106]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[217]

Drug(s) Affected By Histone H2B type 2-E (H2BC21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[56]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[62]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[96]

Drug(s) Affected By Collagen alpha-1(XIII) chain (COL13A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[39]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[40]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[19]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[219]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[220]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[212]

Drug(s) Affected By Histone H2A type 2-A (H2AC18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[56]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[221]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[23]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[222]

Drug(s) Affected By Interleukin-27 receptor subunit alpha (IL27RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[223]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[224]

Drug(s) Affected By Pleckstrin homology-like domain family A member 1 (PHLDA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[92]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[105]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[30]

Drug(s) Affected By Rho guanine nucleotide exchange factor 1 (ARHGEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[212]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[225]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[170]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[198]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[147]

Drug(s) Affected By Interferon regulatory factor 7 (IRF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[226]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[33]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[25]

Drug(s) Affected By NADPH oxidase 5 (NOX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[228]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[229]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[230]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[229]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[231]

Drug(s) Affected By Thioredoxin-related transmembrane protein 4 (TMX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[212]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[204]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[170]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[95]

Drug(s) Affected By DNA dC->dU-editing enzyme APOBEC-3G (APOBEC3G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[95]
Bortezomib	DMNO38U	Leukemia		Approved	[10]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[233]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[234]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[225]

Drug(s) Affected By Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[235]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[53]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[237]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[238]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]

Drug(s) Affected By Pirin (PIR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[133]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[136]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[240]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[241]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[242]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[242]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[134]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[242]
Fructose	DM43AN2	Vomiting	MD90	Approved	[243]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[242]

Drug(s) Affected By Phospholipid phosphatase 1 (PLPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[211]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[33]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[23]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[221]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[66]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[245]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[247]
Bortezomib	DMNO38U	Leukemia		Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[238]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[212]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[170]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[248]

Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[249]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[74]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[200]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[136]

Drug(s) Affected By Claudin-3 (CLDN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Guanfacine extended release	DMB1CZ8	Attention deficit hyperactivity disorder	6A05.Z	Approved	[250]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[251]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[10]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[252]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[23]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[253]

Drug(s) Affected By Forkhead box protein O3 (FOXO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[256]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[257]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[50]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[258]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]

Drug(s) Affected By Protein regulator of cytokinesis 1 (PRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[144]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[259]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[136]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]

Drug(s) Affected By Large neutral amino acids transporter small subunit 3 (SLC43A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[260]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[50]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[260]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[50]

Drug(s) Affected By Transcription factor Maf (MAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[167]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[262]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[263]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[264]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[23]

Drug(s) Affected By Histone deacetylase complex subunit SAP30 (SAP30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[39]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[265]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[109]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[184]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[167]

Drug(s) Affected By Endonuclease domain-containing 1 protein (ENDOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[266]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[267]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[238]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[268]

Drug(s) Affected By G2/mitotic-specific cyclin-B2 (CCNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[269]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[271]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[272]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]

Drug(s) Affected By Chromosome-associated kinesin KIF4A (KIF4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[274]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]

Drug(s) Affected By Acyl-CoA 6-desaturase (FADS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[275]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[249]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[56]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[276]
Bortezomib	DMNO38U	Leukemia		Approved	[10]

Drug(s) Affected By Dihydrofolate reductase (DHFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[277]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[278]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[279]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[157]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[280]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[279]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[95]

Drug(s) Affected By Ferritin heavy chain (FTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[281]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[140]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[282]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[283]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[136]

Drug(s) Affected By Sodium/potassium-transporting ATPase subunit beta-1 (ATP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[284]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[41]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[184]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[285]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[286]
Fructose	DM43AN2	Vomiting	MD90	Approved	[75]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[287]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[121]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[288]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[175]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[289]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[290]

Drug(s) Affected By Prostate-specific antigen (KLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[144]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[291]
Selenium	DM25CGV	N. A.	N. A.	Approved	[292]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[293]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[294]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[295]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[296]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[297]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[298]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[299]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[300]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[175]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[301]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[302]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[303]

Drug(s) Affected By Glucose-6-phosphate 1-dehydrogenase (G6PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[220]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[75]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[266]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[144]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[304]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[241]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[305]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[121]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[288]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[235]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[50]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[210]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[308]

Drug(s) Affected By Plasma membrane calcium-transporting ATPase 1 (ATP2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[309]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[310]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[311]

Drug(s) Affected By Kallikrein-2 (KLK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[293]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[312]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[313]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[167]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[314]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[315]

Drug(s) Affected By Amine oxidase A (MAOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[112]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[316]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[317]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]

Drug(s) Affected By Grancalcin (GCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[318]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[319]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[320]

Drug(s) Affected By Transmembrane 4 L6 family member 1 (TM4SF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[147]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[112]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[106]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[321]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]

Drug(s) Affected By Radixin (RDX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Haloperidol	DM96SE0	Delirium		Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[221]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[286]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[322]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[66]

Drug(s) Affected By Squalene synthase (FDFT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[323]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[324]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[325]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]

Drug(s) Affected By Protein phosphatase inhibitor 2 (PPP1R2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[235]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[326]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[224]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[212]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[66]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[327]

Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor C (CDKN2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[328]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[272]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[329]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[330]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[179]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[331]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[332]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[334]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[335]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[336]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[337]

Drug(s) Affected By NADP-dependent malic enzyme (ME1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Selenium	DM25CGV	N. A.	N. A.	Approved	[24]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[338]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[339]

Drug(s) Affected By Lanosterol synthase (LSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[340]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[241]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[340]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[340]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[340]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[33]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[341]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[340]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[241]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[342]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[50]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[284]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[338]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[343]

Drug(s) Affected By CCAAT/enhancer-binding protein delta (CEBPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[283]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]

Drug(s) Affected By 6-phosphogluconate dehydrogenase, decarboxylating (PGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[339]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Methylene blue	DMJAPE7	Acquired methemoglobinemia	3A93	Approved	[344]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[339]

Drug(s) Affected By Ras-related C3 botulinum toxin substrate 3 (RAC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[345]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[39]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[48]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[346]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[212]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[319]

Drug(s) Affected By Protein BTG1 (BTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[347]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[348]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[200]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[283]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[347]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[95]

Drug(s) Affected By Arginase-2, mitochondrial (ARG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[92]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[349]
Selenium	DM25CGV	N. A.	N. A.	Approved	[24]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[321]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[350]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[266]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[242]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[242]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[351]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[242]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]

Drug(s) Affected By Peroxisomal bifunctional enzyme (EHHADH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[352]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[352]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[353]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[354]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[318]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[352]

Drug(s) Affected By Aspartyl/asparaginyl beta-hydroxylase (ASPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[266]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Haloperidol	DM96SE0	Delirium		Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[266]

Drug(s) Affected By Dual specificity protein phosphatase 4 (DUSP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[338]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[95]

Drug(s) Affected By BMP and activin membrane-bound inhibitor homolog (BAMBI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[349]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[338]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[105]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[95]

Drug(s) Affected By Methanethiol oxidase (SELENBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[39]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[40]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[356]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[356]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[357]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[358]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[359]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[360]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[235]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]

Drug(s) Affected By Ras GTPase-activating-like protein IQGAP2 (IQGAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[361]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[167]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[238]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[362]

Drug(s) Affected By Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[351]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[58]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[260]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]

Drug(s) Affected By Endonuclease G, mitochondrial (ENDOG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[363]
Selenium	DM25CGV	N. A.	N. A.	Approved	[24]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[364]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[365]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[366]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[367]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[53]

Drug(s) Affected By Dihydropyrimidinase-related protein 2 (DPYSL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[368]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[369]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[266]

Drug(s) Affected By 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (HIBCH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]

Drug(s) Affected By GPI inositol-deacylase (PGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[212]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[204]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[54]

Drug(s) Affected By N-acetylgalactosaminyltransferase 7 (GALNT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[222]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[211]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[239]

Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 10 (GALNT10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[39]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[370]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]

Drug(s) Affected By Tax1-binding protein 1 (TAX1BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[212]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[371]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[170]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[372]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[147]
Okadaic acid	DM47CO1	Discovery agent	N.A.	Investigative	[373]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[374]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[136]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[136]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[222]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[375]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[212]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit C (EIF3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[328]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[136]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[136]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[53]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[136]

Drug(s) Affected By Kinesin-like protein KIF2C (KIF2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[376]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[274]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]

Drug(s) Affected By Homeobox protein Nkx-3.1 (NKX3-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[293]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[377]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[167]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[378]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[379]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[380]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[41]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[381]

Drug(s) Affected By Rac GTPase-activating protein 1 (RACGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[382]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[274]

Drug(s) Affected By Pantothenate kinase 3 (PANK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[221]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[383]

Drug(s) Affected By DnaJ homolog subfamily B member 9 (DNAJB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[384]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[210]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[385]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[384]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[136]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[321]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[136]

Drug(s) Affected By DNA dC->dU-editing enzyme APOBEC-3B (APOBEC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[161]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[39]

Drug(s) Affected By Integral membrane protein 2B (ITM2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[386]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[387]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[212]

Drug(s) Affected By Glutathione S-transferase kappa 1 (GSTK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[388]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[389]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[233]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[375]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[390]

Drug(s) Affected By Heme-binding protein 2 (HEBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[391]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[217]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[392]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[167]

Drug(s) Affected By Sestrin-1 (SESN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[208]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[157]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[136]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[393]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[394]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[395]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[396]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[397]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[398]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[399]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[400]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[401]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[402]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[144]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[403]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[404]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[405]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[406]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[407]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[408]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[409]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[410]

Drug(s) Affected By Suppressor of cytokine signaling 3 (SOCS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[144]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[411]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Fedratinib	DM4ZBK6	Myelofibrosis	2A20.2	Approved	[412]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[54]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[412]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[134]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[413]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[414]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[415]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[416]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[333]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[417]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[418]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[419]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[416]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[420]

Drug(s) Affected By Nucleophosmin (NPM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[382]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[421]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[422]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[423]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[369]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]

Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[424]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[425]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[426]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[247]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[427]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[39]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[428]

Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[144]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[429]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[430]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[431]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[432]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[433]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[434]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[435]
Mestranol	DMG3F94	Contraception	QA21	Approved	[436]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[437]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Naphthalene dioxygenase (doxB)	DEE76YZ	NDOB_PSEU8	Substrate	[1]
Biphenyl dioxygenase (bphC)	DEUX61H	BPHC_PSEFK	Substrate	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Gene/Protein Processing	[2]
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (HIBCH)	OTU2VHWR	HIBCH_HUMAN	Gene/Protein Processing	[3]
6-phosphogluconate dehydrogenase, decarboxylating (PGD)	OTVG296F	6PGD_HUMAN	Gene/Protein Processing	[3]
Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A)	OTRHPFO2	AN32A_HUMAN	Gene/Protein Processing	[2]
Acyl-CoA 6-desaturase (FADS2)	OTUX531P	FADS2_HUMAN	Gene/Protein Processing	[3]
Aldehyde oxidase (AOX1)	OT2FZP6H	AOXA_HUMAN	Gene/Protein Processing	[2]
Alpha-globin transcription factor CP2 (TFCP2)	OTA246TE	TFCP2_HUMAN	Gene/Protein Processing	[2]
Amine oxidase A (MAOA)	OT8NIWMQ	AOFA_HUMAN	Gene/Protein Processing	[3]
Arginase-2, mitochondrial (ARG2)	OTCPI0E8	ARGI2_HUMAN	Gene/Protein Processing	[3]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Gene/Protein Processing	[4]

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