General Information of Disease (ID: DIS093I0)

Disease Name Immunodeficiency
Synonyms immunodeficiency syndrome; immuno-deficiency; immunodeficiency; immunodeficiency disorder
Disease Class 4A00-4A85: Immunodeficiency
Definition Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.
Disease Hierarchy
DISYKSRF: Genetic disease
DISAEGPH: Immune system disorder
DIS093I0: Immunodeficiency
ICD Code
ICD-11
ICD-11: 4A00-4A85
ICD-9
ICD-9: 279.3
Expand ICD-11
'4B4Y
Expand ICD-9
279.3
Disease Identifiers
MONDO ID
MONDO_0021094
MESH ID
D007153
UMLS CUI
C0021051
MedGen ID
7034
HPO ID
HP:0002721
SNOMED CT ID
234532001

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 10 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Alemtuzumab DMZL3IV Approved Antibody [1]
Busulfan DMXYJ9C Approved Small molecular drug [2]
Cyclophosphamide DM4O2Z7 Approved Small molecular drug [3]
Elapegademase DMS7OU8 Approved NA [4]
Fludarabine DMVRLT7 Approved Small molecular drug [5]
Human immune globulin DMVGFD1 Approved NA [6]
Hyqvia DM0RXF5 Approved NA [7]
Immune globulin DMX2OMJ Approved NA [6]
Thiotepa DMIZKOP Approved Small molecular drug [8]
Vidarabine DM0N85H Approved Small molecular drug [9]
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⏷ Show the Full List of 10 Drug(s)
This Disease is Treated as An Indication in 3 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
GSK2696273 DMP5O1U Preregistration NA [10]
BPX-501 DMIMA4V Phase 1/2 NA [10]
Ex vivo adenosine deaminase-transduced hematopoietic stem cell therapy DMIREUZ Phase 1/2 NA [11]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 168 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
C1QB TT8A9DM Limited Biomarker [12]
C3 TTJGY7A Limited Biomarker [13]
C5 TTKANGO Limited Biomarker [14]
CD19 TTW640A Limited Biomarker [15]
CD40LG TTIJP3Q Limited Biomarker [16]
CFD TT8D13I Limited Biomarker [17]
CFH TTUW6OP Limited Biomarker [18]
DNMT3B TT6VZ78 Limited Genetic Variation [19]
ICOS TTE5VP6 Limited Biomarker [20]
IL2RB TT9721Y Limited Biomarker [21]
KRT19 TT3JF9E Limited Biomarker [22]
LEPR TT0HD6V Limited Biomarker [23]
TNFRSF13B TTL9OD4 Limited Genetic Variation [24]
TNFRSF4 TTL31H0 Limited Biomarker [25]
TYK2 TTBYWP2 Limited Genetic Variation [26]
CD3E TTZAT79 moderate Biomarker [27]
CTPS1 TTN12BZ moderate Biomarker [28]
HBB TTM6HK1 moderate Altered Expression [29]
IKBKB TTJ3E9X moderate Biomarker [30]
IRAK4 TTILUKB moderate Genetic Variation [31]
MYD88 TTB6Q2O moderate Biomarker [32]
PIK3CD TTGBPJE moderate Biomarker [33]
TFRC TT8MG4S moderate Biomarker [34]
ABCA1 TTJW1GN Strong Altered Expression [35]
ABCG1 TTMWDGU Strong Altered Expression [35]
ABL1 TT6B75U Strong Biomarker [36]
ACVR1B TTPKHTZ Strong Biomarker [37]
ACVR2B TTLFRKS Strong Biomarker [38]
ADA TTLP57V Strong Genetic Variation [39]
AGRP TT4DE1O Strong Biomarker [40]
AICDA TTKRTP6 Strong Biomarker [41]
ALKBH5 TTOHB1M Strong Biomarker [42]
AMD1 TTBFROQ Strong Biomarker [43]
APCS TTB7VAT Strong Biomarker [44]
APLNR TTJ8E43 Strong Biomarker [45]
APOBEC3G TTP96KH Strong Biomarker [46]
APOL1 TTDB8PW Strong Biomarker [47]
ATM TTKBM7V Strong Biomarker [48]
BACE2 TT69DB8 Strong Altered Expression [49]
BCL11A TTR61MW Strong Genetic Variation [50]
BCL6 TTC9YX5 Strong Genetic Variation [51]
BST2 TT90BJT Strong Biomarker [52]
BTK TTGM6VW Strong Biomarker [53]
C3AR1 TTI6B3F Strong Biomarker [54]
CACNA1C TTZIFHC Strong Biomarker [55]
CASP6 TTKW4ML Strong Biomarker [56]
CAV1 TTXUBN2 Strong Biomarker [57]
CCR2 TTFZYTO Strong Genetic Variation [58]
CCR3 TTD3XFU Strong Altered Expression [59]
CCR5 TTJIH8Q Strong Biomarker [60]
CCR9 TTIPS8B Strong Biomarker [61]
CD160 TTOFEAS Strong Biomarker [62]
CD24 TTCTYNP Strong Biomarker [63]
CD28 TTQ13FT Strong Altered Expression [64]
CD36 TTPJMCU Strong Biomarker [65]
CD4 TTN2JFW Strong Biomarker [66]
CD40 TT1ERKL Strong Altered Expression [67]
CD47 TT28S46 Strong Biomarker [68]
CD58 TT5KSBY Strong Altered Expression [69]
CD69 TTPQE9F Strong Biomarker [70]
CD70 TTNCIE0 Strong Biomarker [71]
CD83 TTT9MRQ Strong Biomarker [72]
CD9 TTZEIBV Strong Biomarker [73]
CDC123 TT3PRUG Strong Biomarker [74]
CFB TTA0P7K Strong Genetic Variation [75]
CLEC9A TTGUSRB Strong Altered Expression [76]
CMKLR1 TT4UGZL Strong Biomarker [77]
CTLA4 TTI2S1D Strong Biomarker [78]
CXCR4 TTBID49 Strong Genetic Variation [79]
CYBB TT5T8MR Strong Biomarker [80]
DMD TTWLFXU Strong Biomarker [81]
DPP4 TTDIGC1 Strong Biomarker [82]
DSG3 TTEO4P8 Strong Biomarker [83]
DUSP5 TTZN92A Strong Biomarker [84]
DUT TTH6MBO Strong Genetic Variation [85]
E2F3 TTWIJYH Strong Biomarker [86]
EGFL7 TT7WD0H Strong Altered Expression [87]
EIF2AK4 TT9U4EP Strong Biomarker [88]
ENPEP TT9PBIL Strong Genetic Variation [89]
EPHB6 TTZEMUY Strong Biomarker [90]
EREG TTYSB89 Strong Biomarker [91]
F8 TT1290U Strong Altered Expression [92]
FABP1 TTIV96N Strong Biomarker [93]
FBXO11 TT6G10V Strong Biomarker [94]
FGL2 TTYBS89 Strong Biomarker [95]
FLT3 TTGJCWZ Strong Biomarker [96]
FSHR TTZFDBT Strong Biomarker [97]
GAA TTLPC70 Strong Biomarker [98]
GJB6 TTAU8SJ Strong Genetic Variation [99]
GNAO1 TTAXD8Z Strong Genetic Variation [100]
GPRC5D TTHRAPJ Strong Biomarker [45]
GSS TTVEWR4 Strong Altered Expression [35]
GUCY2C TTLDPRG Strong Altered Expression [101]
HHAT TT1VNCG Strong Altered Expression [102]
HLA-DQB2 TTL7VOU Strong Genetic Variation [100]
HOXA13 TTN26OM Strong Altered Expression [103]
HTATIP2 TTC6IX5 Strong Genetic Variation [104]
IFNL3 TTRF4Q2 Strong Genetic Variation [105]
IL13 TT0GVCH Strong Biomarker [106]
IL16 TTW4R0B Strong Altered Expression [107]
IL21 TT9QEJ6 Strong Altered Expression [108]
IL22 TTLDX4N Strong Altered Expression [108]
IL2RA TT10Y9E Strong Biomarker [109]
IL3RA TTENHJ0 Strong Biomarker [110]
IL4R TTDWHC3 Strong Altered Expression [111]
IL7 TT8FRMO Strong Biomarker [112]
IRF8 TTHUBNK Strong Genetic Variation [113]
ITGAL TT48WR6 Strong Biomarker [114]
ITGB2 TTIJWR7 Strong Altered Expression [115]
ITK TT3C80U Strong Genetic Variation [116]
JAK3 TTT7PJU Strong Genetic Variation [117]
KDM5A TTIG67W Strong Biomarker [118]
KIR2DL2 TTU0P73 Strong Biomarker [119]
LAG3 TTNVXAW Strong Biomarker [120]
LAMB3 TT2WOUQ Strong Altered Expression [121]
LAMP1 TTC214J Strong Altered Expression [108]
LANCL1 TTZW8NS Strong Altered Expression [122]
LMO2 TTFX379 Strong Biomarker [123]
LRRC32 TT0FAYT Strong Altered Expression [124]
LTB4R TTN53ZF Strong Biomarker [125]
MALT1 TTCI81G Strong Biomarker [126]
MAPK1 TT4TQBX Strong Altered Expression [127]
MLYCD TT9Z4YD Strong Biomarker [128]
MS4A1 TTUE541 Strong Biomarker [129]
NFKB2 TTKLNRV Strong Biomarker [130]
NR0B1 TTTK36V Strong Altered Expression [131]
NR1H3 TTECBXN Strong Biomarker [132]
ORAI1 TTE76YK Strong Genetic Variation [133]
PAK2 TT279WO Strong Biomarker [134]
PCSK6 TT75LN9 Strong Biomarker [135]
PDCD1 TTNBFWK Strong Biomarker [136]
PDGFC TTOABM9 Strong Genetic Variation [137]
PDGFD TTSN0GA Strong Altered Expression [138]
PDXP TT9UYG4 Strong Biomarker [139]
PIN1 TTJNTSI Strong Biomarker [140]
PKD2L1 TTAHD89 Strong Biomarker [141]
PLD1 TT3T17P Strong Genetic Variation [142]
PNP TTMCF1Y Strong Genetic Variation [143]
PPT1 TTSQC14 Strong Biomarker [144]
PRKDC TTK3PY9 Strong Biomarker [145]
PSMB6 TT8EPLT Strong Genetic Variation [146]
PTBP1 TTWMX0U Strong Biomarker [147]
PTPRC TTUS45N Strong Biomarker [148]
RBPJ TT72D4Z Strong Altered Expression [149]
ROBO4 TT3S9TY Strong Biomarker [150]
ROR1 TTDEJAU Strong Altered Expression [151]
S100B TTQ0V86 Strong Biomarker [152]
SGCB TTEDCQ0 Strong Biomarker [153]
SLC3A2 TT5CZSM Strong Biomarker [154]
SPAG6 TTDAKTW Strong Biomarker [155]
SPN TTOZAX0 Strong Biomarker [156]
STAT1 TTN7R6K Strong Biomarker [157]
TCL1A TTUKRDV Strong Genetic Variation [158]
TDP1 TT64IHJ Strong Biomarker [159]
TGM1 TT7A949 Strong Altered Expression [160]
THPO TTCG5PE Strong Biomarker [161]
THRB TTGER3L Strong Biomarker [63]
TLR6 TTWRI8V Strong Biomarker [162]
TLR7 TTRJ1K4 Strong Biomarker [163]
TNFRSF17 TTZ3P4W Strong Biomarker [164]
TNFSF13B TTWMIDN Strong Biomarker [165]
TNFSF4 TTBW580 Strong Biomarker [166]
TNIK TTPB1W3 Strong Biomarker [167]
TP53BP1 TTX4UE9 Strong Biomarker [168]
WAS TTE8T73 Strong Genetic Variation [169]
XIAP TTK3WBU Strong Biomarker [170]
ZAP70 TTUMHT8 Strong Biomarker [171]
IL21R TTZO9B0 Definitive Autosomal recessive [172]
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⏷ Show the Full List of 168 DTT(s)
This Disease Is Related to 2 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC11A1 DT650XW Strong Biomarker [173]
SLC4A9 DTSQY0W Strong Biomarker [174]
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This Disease Is Related to 8 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
AK2 DEY1FJO Strong Biomarker [175]
G6PC3 DEE1B8O Strong Biomarker [176]
HSD17B7 DEDMWFX Strong Biomarker [177]
NT5C2 DE1DOKJ Strong Altered Expression [178]
PGM3 DER0EN5 Strong Biomarker [179]
SULT1A1 DEYWLRK Strong Altered Expression [180]
TPMT DEFQ8VO Strong Altered Expression [181]
UBASH3B DE10BJ5 Strong Altered Expression [122]
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⏷ Show the Full List of 8 DME(s)
This Disease Is Related to 221 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
C4A OTXMOYXU Limited Biomarker [182]
C8A OTIJ65J4 Limited Biomarker [183]
C8B OTGDJJOK Limited Biomarker [184]
C9 OT7I5FDX Limited Biomarker [185]
MAGT1 OTQSAV5C Limited Biomarker [186]
RNF168 OT6AZXX8 Limited Genetic Variation [187]
TAOK2 OTNUMOZ1 Limited Autosomal recessive [188]
BCR OTCN76C1 moderate Altered Expression [189]
CARD11 OTRCTLYC moderate Genetic Variation [190]
CD247 OT45FGUX moderate Biomarker [191]
CORO1A OTVAZOHC moderate Genetic Variation [192]
DCTN4 OTM7C943 moderate Biomarker [193]
IL12RB1 OTM1IJO2 moderate Genetic Variation [194]
LYST OTIUB1B3 moderate Biomarker [195]
PIK3R1 OT5BZ1J9 moderate Genetic Variation [196]
POMP OTMPM1P5 moderate Genetic Variation [197]
STIM1 OT8CLQ1W moderate Genetic Variation [198]
ABCG4 OT2XJIOG Strong Altered Expression [35]
ACAD8 OT3JI5GB Strong Biomarker [199]
ACIN1 OTK81F92 Strong Biomarker [200]
ACSBG1 OTM040MW Strong Biomarker [201]
ACTB OT1MCP2F Strong Biomarker [202]
ACTR1A OT1QAU16 Strong Biomarker [203]
ADAM23 OTVWT6JZ Strong Altered Expression [204]
ADAMTS12 OTG7HEA2 Strong Biomarker [205]
ADGRB1 OTJSEXRC Strong Altered Expression [206]
AIRE OTA7G1Y1 Strong Altered Expression [207]
AKAP13 OTOZAR14 Strong Biomarker [170]
ANGPTL1 OTXIN6V5 Strong Biomarker [203]
ANKRD36B OT3MW415 Strong Altered Expression [208]
ANOS1 OTZJT4KN Strong Biomarker [209]
AP1AR OT6CFK4K Strong Biomarker [210]
APBB1 OTZPVSSC Strong Biomarker [211]
APOBEC2 OT4CCS0Q Strong Biomarker [203]
APOBEC3C OTPL0AI1 Strong Genetic Variation [212]
APOBEC3F OT750IJM Strong Altered Expression [213]
APOBEC3H OTXIH4X4 Strong Biomarker [214]
ARFRP1 OTP1OV78 Strong Biomarker [203]
ARL4C OTQ3QNNU Strong Biomarker [215]
ARMH1 OTTJC0D6 Strong Altered Expression [122]
ARR3 OTRZ00CH Strong Biomarker [216]
ART1 OT7FBG5W Strong Biomarker [217]
ARTN OTWIWGL6 Strong Biomarker [40]
BCL10 OT47MCLI Strong Altered Expression [218]
BCL11B OT8KKCVJ Strong Genetic Variation [219]
BLM OTEJOAJX Strong Biomarker [220]
BMPR1B OTGFN0OD Strong Biomarker [221]
CALHM6 OTLX9B4Y Strong Altered Expression [222]
CARMIL2 OTV5S1J2 Strong Genetic Variation [223]
CBFB OTIAC6W4 Strong Biomarker [224]
CBLIF OTNE20WU Strong Genetic Variation [106]
CCL4L2 OTDBSXOU Strong Altered Expression [59]
CCNT1 OTDYVGCP Strong Biomarker [225]
CD1C OT4XINUJ Strong Biomarker [226]
CD207 OTI9RUDN Strong Biomarker [227]
CD68 OTOYEY3J Strong Altered Expression [228]
CD8A OTDWQJXK Strong Biomarker [229]
CDCA5 OTZLCQ5U Strong Altered Expression [122]
CDH4 OT8LH3HN Strong Biomarker [230]
CHD7 OTHNIZWZ Strong Biomarker [231]
CHP1 OTHTXN1A Strong Biomarker [73]
CIITA OTRJNZFO Strong Biomarker [232]
CITED1 OTUJQ3VL Strong Biomarker [233]
CLEC11A OT9KBH7C Strong Biomarker [170]
CLEC16A OTLGV5SV Strong Biomarker [234]
CMAS OTFQJG3C Strong Biomarker [235]
CNBP OTTGM9NK Strong Altered Expression [35]
CPQ OTTNZNLD Strong Biomarker [236]
CRABP2 OTY01V9G Strong Altered Expression [237]
CRB1 OTXYUNG0 Strong Biomarker [238]
CRYGC OTYSTQWI Strong Biomarker [239]
CT83 OTQEGHAB Strong Biomarker [240]
CTPS2 OT2X9YO1 Strong Genetic Variation [28]
CXADR OT9ZP02A Strong Biomarker [216]
CXCL14 OTM189TA Strong Altered Expression [241]
CXCL17 OTRCEVIZ Strong Biomarker [242]
CYTH1 OTYH9NRJ Strong Biomarker [243]
DAZAP2 OTNURO9F Strong Biomarker [244]
DCBLD2 OTB71I02 Strong Biomarker [245]
DEF6 OTIRBYVK Strong Biomarker [78]
DOCK8 OTNQLL21 Strong Biomarker [246]
DRG1 OTIFYMI3 Strong Biomarker [247]
EBNA1BP2 OTBRVMZH Strong Altered Expression [122]
EDA OTAKS5WS Strong Genetic Variation [99]
EFS OT06O7XL Strong Biomarker [248]
EIF3D OTDOMP80 Strong Biomarker [249]
EIF4A1 OTMTBX6N Strong Biomarker [250]
EIF4A2 OT08H03R Strong Biomarker [250]
EMP1 OTSZHUHQ Strong Biomarker [251]
EPG5 OT3P5HQD Strong Biomarker [252]
ERCC6L OTE9V7D9 Strong Biomarker [253]
ERO1A OTVKOQWM Strong Biomarker [254]
ERVW-1 OTWV8DXJ Strong Biomarker [255]
ESAM OTF518AI Strong Biomarker [256]
ESRP1 OTNCS4SL Strong Biomarker [257]
ETV4 OT8C98UZ Strong Biomarker [258]
FCN2 OTTHJBKZ Strong Biomarker [259]
FCN3 OTPRENLS Strong Biomarker [260]
FERMT3 OTFQOT3C Strong Genetic Variation [261]
FLT3LG OTU0YGC4 Strong Biomarker [262]
FRS2 OTDMD800 Strong Altered Expression [263]
GAB2 OTBFN705 Strong Biomarker [264]
GCHFR OTEOT8GI Strong Altered Expression [122]
GIPC1 OTXLVCPJ Strong Biomarker [265]
GLRX3 OTUPAU1N Strong Biomarker [266]
GPRC5C OT45AJT3 Strong Biomarker [45]
GZMM OTEC5CWT Strong Biomarker [267]
HAND2 OTCXYW4Y Strong Genetic Variation [99]
HAT1 OT307KEN Strong Biomarker [268]
HAVCR2 OTOL603T Strong Altered Expression [269]
HBG1 OTVL4NSU Strong Biomarker [270]
HBG2 OT4J48JJ Strong Biomarker [270]
HES6 OTWO5SCF Strong Biomarker [271]
HOXB4 OTH1HRW5 Strong Altered Expression [272]
HSPH1 OTVRR73T Strong Biomarker [273]
ICAM3 OTTZ5A5D Strong Biomarker [227]
IFITM3 OT2QP8D3 Strong Altered Expression [274]
IGFALS OTTWCZYM Strong Biomarker [275]
IKBKG OTNWJWSD Strong Genetic Variation [276]
IL10RA OTOX3D1D Strong Biomarker [277]
IL3 OT0CQ35N Strong Biomarker [278]
INA OT1D33T4 Strong Biomarker [279]
IPO7 OTDFMQ00 Strong Biomarker [280]
IRF7 OTC1A2PQ Strong Altered Expression [281]
IRGM OTKD3O5Z Strong Biomarker [282]
ITIH4 OT460OO1 Strong Biomarker [35]
IVL OT4VPNGY Strong Biomarker [160]
KIF22 OTY6X6BL Strong Altered Expression [283]
LAMP3 OTN0XL3W Strong Altered Expression [284]
LAMTOR2 OTHEDISB Strong Altered Expression [285]
LARP6 OTUQ9QS9 Strong Biomarker [286]
LHX8 OT0DFL7C Strong Genetic Variation [287]
LIG1 OTEEQS43 Strong Biomarker [288]
LRBA OTOUZN9G Strong Biomarker [289]
LY6E OTMG16BZ Strong Biomarker [290]
MAN2B2 OTU9V3PE Strong Biomarker [291]
MAVS OTTQ0J64 Strong Biomarker [292]
MCF2L OTEURA8N Strong Biomarker [293]
MCM3AP OT895FEC Strong Genetic Variation [197]
MESP1 OTY5QDBN Strong Biomarker [294]
METTL3 OTSXP1M3 Strong Altered Expression [295]
MFAP1 OTZN4FT3 Strong Altered Expression [296]
MKKS OTLF5T11 Strong Biomarker [297]
MKS1 OT83W5PB Strong Biomarker [297]
MNAT1 OTXLOYCB Strong Altered Expression [122]
MOV10 OT0KAY9G Strong Biomarker [298]
MRTFA OTCVXASM Strong Genetic Variation [299]
MTUS1 OTBPALMU Strong Biomarker [300]
MUC20 OTYYE1GK Strong Biomarker [301]
MXD1 OTS5CTHX Strong Altered Expression [302]
MYCL OT1MFQ5U Strong Biomarker [303]
MYSM1 OTO73N00 Strong Biomarker [304]
NAP1L1 OTI7WBZV Strong Biomarker [305]
NBAS OTW9IBRI Strong Biomarker [306]
NCOR2 OTY917X0 Strong Biomarker [307]
NFAT5 OTKIE59S Strong Biomarker [308]
NFE2 OTLM94BI Strong Altered Expression [309]
NHEJ1 OTYOO05J Strong Genetic Variation [310]
NOG OTGRHHPG Strong Biomarker [311]
NR2F2 OTJFS67N Strong Biomarker [203]
NRSN1 OT1KKXC8 Strong Biomarker [73]
NSFL1C OTIKQF3U Strong Biomarker [170]
OBP2A OTBIJ5TI Strong Altered Expression [283]
OPTN OT2UXWH9 Strong Biomarker [305]
ORAI3 OTUP3OH3 Strong Altered Expression [312]
PDLIM7 OTAZVODU Strong Biomarker [313]
PDSS1 OTXGVHAB Strong Biomarker [293]
PGLYRP1 OTBTPR2T Strong Biomarker [314]
PIGQ OTOD93DQ Strong Biomarker [315]
PIP OTH719AH Strong Biomarker [316]
PITX1 OTA0UN4C Strong Genetic Variation [317]
PLEC OTU4XDEG Strong Altered Expression [318]
PLEK OTB73XXA Strong Biomarker [170]
POLR3E OT69PWBM Strong Biomarker [248]
PRF1 OTFVXD7H Strong Biomarker [319]
PRUNE2 OTGW2974 Strong Biomarker [320]
PSMD7 OT7PZZ4K Strong Altered Expression [122]
PTBP2 OTF4S7NE Strong Biomarker [321]
RAB27A OT9SQRWY Strong Genetic Variation [322]
RAB6A OTLS86J5 Strong Biomarker [323]
RABEPK OTCZSREH Strong Altered Expression [122]
RAC2 OTAOHFNH Strong Biomarker [324]
RAD1 OT886MA8 Strong Biomarker [325]
RAG2 OTG9UYTW Strong Biomarker [159]
RAPH1 OTMQXW7S Strong Biomarker [201]
RASGRP1 OTX9WN2E Strong Biomarker [326]
RASGRP3 OTEMEV3P Strong Biomarker [327]
RBM8A OT5SR6G0 Strong Biomarker [328]
RBP2 OTR8QG5V Strong Altered Expression [237]
RHOH OT1J9SEB Strong Genetic Variation [329]
RNF139 OT0PR1X5 Strong Biomarker [330]
RPL17 OTTYMPS6 Strong Altered Expression [331]
RUVBL2 OTGWJ4T4 Strong Altered Expression [332]
SALL2 OTQWI68Q Strong Altered Expression [333]
SAMHD1 OTBCIBC7 Strong Biomarker [334]
SCD5 OTSSUQ3Z Strong Biomarker [335]
SFTPB OTOHS07E Strong Altered Expression [336]
SH2D1A OTLU49I5 Strong Biomarker [44]
SMCHD1 OTBV52DR Strong Biomarker [337]
SNRNP40 OTSRL6QO Strong Genetic Variation [338]
SOAT1 OTB4Y5RJ Strong Biomarker [339]
SP110 OTFW6WH7 Strong Genetic Variation [340]
SPATA2 OTOA45GL Strong Altered Expression [331]
ST8SIA1 OTGND2YZ Strong Biomarker [341]
SYMPK OTYAUDXV Strong Altered Expression [342]
SYN1 OTMNPWC1 Strong Biomarker [343]
TAP2 OTWSYFI7 Strong Biomarker [344]
TAPBP OTL81AVZ Strong Biomarker [344]
TARBP2 OT1QQ8H3 Strong Biomarker [328]
TAT OT2CJ91O Strong Biomarker [345]
TCL1B OT4CSO39 Strong Genetic Variation [158]
TMED2 OTBLO7RW Strong Biomarker [73]
TNFRSF10D OTOSRDJT Strong Genetic Variation [346]
TNXB OTVBWAV5 Strong Biomarker [347]
TP53BP2 OTOWJ2Y4 Strong Altered Expression [348]
TPPP OTCFMSUF Strong Biomarker [73]
TRIM13 OTQIUACB Strong Biomarker [216]
TRIM5 OTMZH7EJ Strong Genetic Variation [349]
TSPAN32 OTSXW7EW Strong Biomarker [217]
TTC7A OTDHLPQM Strong Genetic Variation [350]
IL21R OTDIOB63 Definitive Autosomal recessive [172]
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⏷ Show the Full List of 221 DOT(s)

References

1 Secondary Immunodeficiency and Risk of Infection Following Immune Therapies in Neurology. CNS Drugs. 2021 Nov;35(11):1173-1188.
2 Busulfan FDA Label
3 Cyclophosphamide FDA Label
4 ClinicalTrials.gov (NCT01420627) EZN-2279 in Patients With ADA-SCID. U.S. National Institutes of Health.
5 Fludarabine FDA Label
6 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
7 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
8 Thiotepa FDA Label
9 Vidarabine FDA Label
10 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
11 Clinical pipeline report, company report or official report of GlaxoSmithKline.
12 A homozygous point mutation results in a stop codon in the C1q B-chain of a C1q-deficient individual.Immunogenetics. 1988;27(4):259-64. doi: 10.1007/BF00376120.
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