Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMX8BS5)

• Drug Name: ELLAGIC ACID Drug Info
• Synonyms: ellagic acid; 476-66-4; Benzoaric acid; Lagistase; Eleagic acid; Alizarine Yellow; Elagostasine; 2,3,7,8-Tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione; Ellagic acid dihydrate; Llagic acid; Acide ellagique; Acido elagico; Acidum ellagicum; C.I. 55005; Gallogen (VAN); Gallogen (astringent); C.I. 75270; Ellagate; Ellagic acid [INN:DCF]; UNII-19YRN3ZS9P; Acido elagico [INN-Spanish]; CCRIS 774; Gallogen, astringent; Acide ellagique [INN-French]; Acidum ellagicum [INN-Latin]; MLS000069632; C14H6O8; EINECS 207-508-3; NSC407286; NSC 40728

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5281855
  ChEBI ID: CHEBI:4775
  CAS Number: CAS 476-66-4
  TTD Drug ID: DMX8BS5

Molecule-Related Drug Atlas

Drug(s) Targeting Carbonic anhydrase VI (CA-VI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[11]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[12]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[13]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[14]
SAR566658	DM6Q295	Solid tumour/cancer	2A00-2F9Z	Phase 2	[15]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[16]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[17]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[13]

Drug(s) Targeting Carbonic anhydrase I (CA-I)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[11]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[18]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[18]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[19]
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[18]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[13]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
CG-100649	DMIKMA9	Arthritis	FA20	Phase 3	[20]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[13]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[14]

Drug(s) Targeting Carbonic anhydrase XII (CA-XII)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[11]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[21]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[13]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[13]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[14]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[17]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[13]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[2]

Drug(s) Targeting Carbonic anhydrase II (CA-II)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[11]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[21]
Dorzolamide	DMA17D0	Ocular hypertension	9C61.01	Approved	[22]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[23]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[24]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[24]
Cyclothiazide	DMJ4AWC	Congestive heart failure	BD10	Approved	[25]
Ethinamate	DMK57GB	Insomnia	7A00-7A0Z	Approved	[26]
Benzthiazide	DMQWZ0H	High blood pressure	BA00	Approved	[27]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[13]

Drug(s) Targeting Carbonic anhydrase XIV (CA-XIV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[28]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[16]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[13]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[13]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[14]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[16]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[17]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[13]

Drug(s) Targeting Mothers against decapentaplegic homolog 3 (SMAD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FLUORESCEIN	DMQTFAO	Ocular disease	1F00.1Z	Approved	[5]
SIS-3	DMWBCTA	Renal fibrosis	GC01	Preclinical	[29]
GNF-PF-2272	DMONK0F	Discovery agent	N.A.	Investigative	[5]

Drug(s) Targeting Carbonic anhydrase (CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[30]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[12]
Quinethazone	DMWCOSR	Hypertension	BA00-BA04	Approved	[31]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[13]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[13]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[14]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[32]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]
PMID30074415-Compound-21	DM3NPOU	N. A.	N. A.	Patented	[33]

Drug(s) Targeting Heat shock protein 70 (HSP70)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AG-858	DMNQ5T2	leukaemia	2A60-2B33	Phase 2	[34]
AEG-33773	DMSBLOU	Diabetic neuropathy	8C0Z	Phase 2	[35]
Enkastim-ev	DMGLHYU	Solid tumour/cancer	2A00-2F9Z	Phase 1	[36]
Minnelide 001	DM5VEN9	Gastric adenocarcinoma	2B72	Phase 1	[37]
BRX-005	DMTDWIE	Diabetic foot ulcer	BD54	Phase 1	[38]
Minnelide	DMDER9S	Solid tumour/cancer	2A00-2F9Z	Phase 1	[39]
AG-707	DM7PLMJ	Herpes simplex virus infection	1F00	Phase 1	[40]
H-103	DMRCHOU	Metastatic malignant neoplasm	2D50-2E09	Phase 1	[41]
NK-1001	DMZMQDN	Atrial fibrillation	BC81.3	Discontinued in Phase 2	[42]
Bimoclomol	DMOP95G	Diabetic complication	5A2Y	Discontinued in Phase 2	[43]

Drug(s) Targeting Casein kinase II alpha (CSNK2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CX-4945	DMWE7B9	Coronavirus infection	1D92	Phase 2	[39]
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[44]
EMODIN	DMAEDQG	Coronavirus Disease 2019 (COVID-19)	1D6Y	Terminated	[3]
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol	DMSKJ1X	Discovery agent	N.A.	Investigative	[45]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[3]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[3]
PMID24900749C1a	DMZPUSO	Discovery agent	N.A.	Investigative	[46]
AdoC(Dpr)2AlaArg6	DM2TWSZ	Discovery agent	N.A.	Investigative	[47]
PMID22115617C2c	DMX5UKA	Discovery agent	N.A.	Investigative	[48]
5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole	DM3JB6S	Discovery agent	N.A.	Investigative	[3]

Drug(s) Targeting Carbonic anhydrase IV (CA-IV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[11]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[49]
Brinzolamide	DMBAPFG	Ocular hypertension	9C61.01	Approved	[18]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[13]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[13]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[14]
Sodium pyruvate	DMST6A3	Asthma	CA23	Phase 1/2	[50]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[32]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]

Drug(s) Targeting Tyrosine-protein kinase SYK (SYK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fostamatinib	DM6AUHV	Immune thrombocytopenic purpura	3B64.13	Approved	[51]
Fostamatinib disodium	DM3274D	Thrombocytopenia	3B64	Phase 3	[52]
Cerdulatinib	DMSCR2H	B-cell lymphoma	2A86	Phase 2	[53]
TAK-659	DMJH3U0	Diffuse large B-cell lymphoma	2A81	Phase 2	[54]
GS-9876	DM9Q2B6	Cutaneous lupus erythematosus	EB5Z	Phase 2	[55]
GS-9973	DMKWCTR	Acute myeloid leukaemia	2A60	Phase 2	[56]
Cevidoplenib	DM9QU5G	Rheumatoid arthritis	FA20	Phase 2	[57]
HM43239	DMV1SDA	Acute myeloid leukaemia	2A60	Phase 1/2	[58]
ALXN2075	DM1BSD8	Non-hodgkin lymphoma	2B33.5	Phase 1/2	[59]
SKI-O-703	DMTSKXR	Rheumatoid arthritis	FA20	Phase 1	[55]

Drug(s) Targeting Carbonic anhydrase IX (CA-IX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[13]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[13]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[14]
INDISULAM	DM9SX6Y	Lymphoma	2A80-2A86	Phase 2	[60]
Girentuximab I-124	DMG3O2Z	Renal cell carcinoma	2C90	Phase 2	[61]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[62]
BAY 79-4620	DM14XQN	Solid tumour/cancer	2A00-2F9Z	Phase 1	[63]
90Y-cG250	DMJR6TC	Solid tumour/cancer	2A00-2F9Z	Phase 1	[64]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]

Drug(s) Targeting Glycogen synthase kinase-3 beta (GSK-3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMO-02	DMJRU3A	Myotonic dystrophy	8C71.0	Phase 2/3	[65]
LY2090314	DMTBFE4	Acute myeloid leukaemia	2A60	Phase 2	[66]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[67]
Tideglusib	DME4LA1	Alzheimer disease	8A20	Phase 2	[68]
9-ING-41	DM57TY3	Myelofibrosis	2A20.2	Phase 2	[69]
Neu-120	DMXKOUC	Parkinson disease	8A00.0	Phase 1/2	[70]
KENPAULLONE	DMAGVXW	Discovery agent	N.A.	Patented	[71]
CHIR-99021	DMB8MNU	Allergic inflammation	4A80-4A85	Patented	[72]
TDZD-8	DMG6Q45	Malignant glioma	2A00.0	Patented	[73]
AR-A014418	DMUPN01	Ovarian cancer	2C73	Patented	[74]

Drug(s) Targeting Squalene monooxygenase (SQLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Naftifine	DMHVBG1	Dermatomycosis	EA60	Approved	[75]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[76]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[1]
FR-194738	DMNACIV	Hypercholesterolaemia	5C80.0	Terminated	[77]
SDZ-87-469	DMBY6CQ	Coronary artery disease	BA80	Terminated	[76]
NB-598	DMJVTQN	N. A.	N. A.	Terminated	[78]
1,2,3,4,6-penta-O-galloyl-beta-D-glucose	DMTK650	Discovery agent	N.A.	Investigative	[1]
Pedunculagin	DMKLRCX	Discovery agent	N.A.	Investigative	[1]
CORILAGIN	DMAC698	Discovery agent	N.A.	Investigative	[1]
ETHYLGALLATE	DMJ6PB8	Discovery agent	N.A.	Investigative	[1]

Drug(s) Affected By DNA fragmentation factor subunit alpha (DFFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[85]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[86]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[87]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[88]

Drug(s) Affected By Nucleolar protein 56 (NOP56)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Selenium	DM25CGV	N. A.	N. A.	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[88]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[94]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[89]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[95]

Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[101]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By Glutathione S-transferase A4 (GSTA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[104]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[106]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[88]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[107]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[108]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[104]

Drug(s) Affected By Regulator of G-protein signaling 5 (RGS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[110]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[113]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[114]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[110]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[116]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[119]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[120]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[121]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[122]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]

Drug(s) Affected By Prostate-specific antigen (KLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[125]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[126]
Selenium	DM25CGV	N. A.	N. A.	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[130]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[131]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[132]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[133]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[134]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[136]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[136]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[140]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[136]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]

Drug(s) Affected By Extracellular superoxide dismutase (SOD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[147]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[148]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[149]

Drug(s) Affected By Fibroblast growth factor receptor 1 (FGFR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[151]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[153]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[154]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[154]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]

Drug(s) Affected By Prostatic acid phosphatase (ACP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[110]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[157]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[158]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[147]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[88]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[159]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[112]

Drug(s) Affected By Insulin-like growth factor-binding protein 2 (IGFBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Selenium	DM25CGV	N. A.	N. A.	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[158]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[165]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[166]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[168]

Drug(s) Affected By Pleiotrophin (PTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[172]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[173]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[114]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[110]
Chondroitin sulfate	DM0N19Y	N. A.	N. A.	Phase 4	[174]

Drug(s) Affected By Filamin-A (FLNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Selenium	DM25CGV	N. A.	N. A.	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[177]

Drug(s) Affected By Bone morphogenetic protein 6 (BMP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[178]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[179]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[178]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[178]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[178]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[178]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[180]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[178]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[181]

Drug(s) Affected By Insulin-like growth factor-binding protein 4 (IGFBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[182]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Selenium	DM25CGV	N. A.	N. A.	Approved	[90]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[151]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[156]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[186]

Drug(s) Affected By Calreticulin (CALR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Selenium	DM25CGV	N. A.	N. A.	Approved	[90]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[190]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[191]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[192]

Drug(s) Affected By Transcription initiation factor IIE subunit beta (GTF2E2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[104]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[104]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[193]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[8]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[194]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[195]

Drug(s) Affected By Protein PML (PML)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[90]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[196]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[198]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[85]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[199]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[199]

Drug(s) Affected By Epidermal growth factor receptor substrate 15 (EPS15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[201]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[107]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[202]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[8]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[194]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[205]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[206]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[207]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[208]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[209]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[210]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[211]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[212]

Drug(s) Affected By Achaete-scute homolog 1 (ASCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[214]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[215]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[110]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[216]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[217]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[194]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[218]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[103]

Drug(s) Affected By GTP-binding nuclear protein Ran (RAN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[219]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[192]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[220]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[221]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[223]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[114]

Drug(s) Affected By Microtubule-associated protein 1A (MAP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[156]
Haloperidol	DM96SE0	Delirium		Approved	[192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[192]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[88]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[224]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[107]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[225]

Drug(s) Affected By Phosphatidylinositol-glycan-specific phospholipase D (GPLD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[134]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[134]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[227]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[227]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[8]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[194]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[229]

Drug(s) Affected By Transcription factor A, mitochondrial (TFAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[231]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[202]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[235]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[236]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[237]

Drug(s) Affected By Nuclear factor NF-kappa-B p100 subunit (NFKB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[238]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[239]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[240]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[241]

Drug(s) Affected By Interferon regulatory factor 9 (IRF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[242]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[170]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[243]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[244]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[88]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[107]

Drug(s) Affected By Peroxisome proliferator-activated receptor delta (PPARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[245]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[246]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[247]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[248]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[249]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[250]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[241]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[251]
Selenium	DM25CGV	N. A.	N. A.	Approved	[90]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[196]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[252]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[253]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[254]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[255]

Drug(s) Affected By Proteolipid protein 2 (PLP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[88]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[107]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[256]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[257]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[258]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[258]

Drug(s) Affected By Early growth response protein 3 (EGR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[259]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[151]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[260]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[261]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[248]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[181]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[92]

Drug(s) Affected By Histone acetyltransferase p300 (EP300)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[262]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[263]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[264]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[85]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[265]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[266]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[107]

Drug(s) Affected By Ras GTPase-activating-like protein IQGAP2 (IQGAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[267]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[268]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[257]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[113]

Drug(s) Affected By cGMP-dependent protein kinase 1 (PRKG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[114]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[269]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[270]
Methamphetamine	DMPM4SK	Anxiety		Approved	[271]
EXISULIND	DMBY56U	Colorectal cancer	2B91.Z	Phase 3	[272]
CP-461	DMEYMTX	Inflammatory bowel disease	DD72	Phase 2	[272]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[194]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[261]

Drug(s) Affected By Septin-2 (SEPTIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[273]
CH-223191	DMMJZYC	Solid tumour/cancer	2A00-2F9Z	Investigative	[274]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[275]

Drug(s) Affected By Monocyte to macrophage differentiation factor (MMD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[276]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[181]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[161]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[277]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[107]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[104]

Drug(s) Affected By TATA box-binding protein-associated factor RNA polymerase I subunit C (TAF1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[278]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[114]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[279]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[280]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[281]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[281]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[282]

Drug(s) Affected By Neuronatin (NNAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[283]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[284]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[285]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[286]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[282]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[287]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[288]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[202]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[218]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[289]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[291]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[291]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[292]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[293]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[294]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[295]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[296]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[297]

Drug(s) Affected By Transcription factor E4F1 (E4F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[90]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[298]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[299]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[8]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[300]

Drug(s) Affected By General transcription factor IIH subunit 4 (GTF2H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[285]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[88]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[107]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[227]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[227]

Drug(s) Affected By Histone-lysine N-methyltransferase EZH1 (EZH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[278]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[114]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[302]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[8]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[269]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[194]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[303]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (INPP5D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[304]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[107]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[104]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[288]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[221]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[193]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[202]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[302]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[110]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase N2 (PTPRN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[261]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[134]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[88]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[288]

Drug(s) Affected By Transcription factor IIIB 90 kDa subunit (BRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[305]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[306]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[8]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[194]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[281]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[281]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[301]

Drug(s) Affected By Transcription factor 12 (TCF12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[90]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[307]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[264]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[107]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[308]

Drug(s) Affected By Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[90]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[183]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[85]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[309]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[107]

Drug(s) Affected By Neuronal PAS domain-containing protein 2 (NPAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[281]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[88]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[113]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[114]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[310]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[8]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[194]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[280]

Drug(s) Affected By Immediate early response gene 2 protein (IER2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[311]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[312]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[202]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[313]

Drug(s) Affected By Autophagy protein 5 (ATG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[314]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[315]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[316]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[317]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[318]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[319]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[320]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[321]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[269]

Drug(s) Affected By Death domain-associated protein 6 (DAXX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[281]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[322]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[323]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Bendamustine hydrochloride	DMFH15Z	leukaemia	2A60-2B33	Approved	[324]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[85]

Drug(s) Affected By Poly(ADP-ribose) glycohydrolase (PARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[276]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[88]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[325]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[114]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[326]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[327]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[327]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[197]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[327]
Fructose	DM43AN2	Vomiting	MD90	Approved	[328]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[327]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[329]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[330]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[178]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[331]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[178]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[332]
Selenium	DM25CGV	N. A.	N. A.	Approved	[333]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[334]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[335]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[336]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[337]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[338]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[339]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[340]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[341]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[342]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[344]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[345]

Drug(s) Affected By Monocyte differentiation antigen CD14 (CD14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[238]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[239]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[346]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[347]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[348]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[349]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[134]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[350]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[351]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[125]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[352]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[353]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[120]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[354]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[355]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[356]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[357]

Drug(s) Affected By Phospholipase A2, membrane associated (PLA2G2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[358]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[198]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[110]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[282]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[359]

Drug(s) Affected By Interleukin-1 receptor type 1 (IL1R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[360]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[360]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[116]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[361]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[362]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[363]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[364]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[183]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[365]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[366]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[367]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[368]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[369]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[370]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[329]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[371]
Selenium	DM25CGV	N. A.	N. A.	Approved	[372]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[355]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[373]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[97]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[374]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[375]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[331]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[376]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[377]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[378]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[379]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[380]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[197]

Drug(s) Affected By Telomerase reverse transcriptase (TERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[381]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[382]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Selenium	DM25CGV	N. A.	N. A.	Approved	[383]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[384]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[385]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[386]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[387]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[101]

Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[388]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[389]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[390]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[151]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[392]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]

Drug(s) Affected By Reversion-inducing cysteine-rich protein with Kazal motifs (RECK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[248]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[393]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[394]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[395]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[313]

Drug(s) Affected By Coagulation factor XII (F12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[161]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[285]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[104]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[104]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[299]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[396]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[258]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[397]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[398]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[399]
Fructose	DM43AN2	Vomiting	MD90	Approved	[116]
Ketoprofen	DMRKXPT	Bursitis		Approved	[116]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[400]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[401]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[402]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[403]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[404]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[353]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[257]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[116]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[405]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[406]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[407]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[408]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[409]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[410]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[411]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[412]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[413]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[414]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[415]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[206]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[416]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[417]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[418]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[419]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[420]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[421]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[422]
Fructose	DM43AN2	Vomiting	MD90	Approved	[116]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[423]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[424]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[238]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[425]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[276]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[426]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[427]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[428]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[429]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[430]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Selenium	DM25CGV	N. A.	N. A.	Approved	[431]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[432]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[196]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[97]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[433]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[434]
Selenium	DM25CGV	N. A.	N. A.	Approved	[435]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[436]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[437]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[438]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[439]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[151]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[440]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[441]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[442]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[443]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[444]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[445]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[369]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[424]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[329]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[178]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[331]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[446]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[178]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[321]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[447]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[448]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[449]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[116]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[450]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[451]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[452]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[401]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[251]

Drug(s) Affected By Glucose-6-phosphate 1-dehydrogenase (G6PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[221]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[116]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[192]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[125]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[453]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[326]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[454]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[151]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[455]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[456]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[125]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[403]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[353]
Selenium	DM25CGV	N. A.	N. A.	Approved	[435]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[457]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[458]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[459]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[460]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[461]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[462]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[463]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[418]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[251]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[464]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[465]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[466]
Selenium	DM25CGV	N. A.	N. A.	Approved	[90]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[408]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[467]

Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[114]
Indomethacin	DMSC4A7	Bursitis		Approved	[468]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[469]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[470]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[97]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[471]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[472]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[341]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[473]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[474]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[475]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[476]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[477]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[478]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[479]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[480]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[481]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[482]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[483]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[484]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[485]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[425]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[486]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[487]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[432]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[488]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[489]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[490]

Drug(s) Affected By Biotin--protein ligase (HLCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[491]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[151]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[202]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[107]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[492]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[89]

Drug(s) Affected By 6-phosphogluconate dehydrogenase, decarboxylating (PGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[151]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Methylene blue	DMJAPE7	Acquired methemoglobinemia	3A93	Approved	[493]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[146]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[321]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[212]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[450]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[451]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[494]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[495]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[487]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[496]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[489]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 1 (MAP3K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[497]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[85]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[88]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[498]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[107]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[499]

Drug(s) Affected By Endonuclease G, mitochondrial (ENDOG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Selenium	DM25CGV	N. A.	N. A.	Approved	[90]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[389]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[497]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[500]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[107]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[227]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[501]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[502]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[503]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[504]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[505]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[506]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[507]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[508]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[509]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]

Drug(s) Affected By Mitogen-activated protein kinase 11 (MAPK11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[90]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[510]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[239]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[511]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[134]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[512]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[241]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[288]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[513]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[370]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[238]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[331]
Selenium	DM25CGV	N. A.	N. A.	Approved	[90]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[514]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[378]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[379]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[515]

Drug(s) Affected By DNA oxidative demethylase ALKBH2 (ALKBH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[134]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[325]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[516]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[194]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[301]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[517]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[212]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[518]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[519]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[520]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[239]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[521]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[101]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase (CA)	TTUNARX	NOUNIPROTAC	Inhibitor	[2]
Carbonic anhydrase I (CA-I)	TTHQPL7	CAH1_HUMAN	Inhibitor	[2]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[2]
Carbonic anhydrase IV (CA-IV)	TTZHA0O	CAH4_HUMAN	Inhibitor	[2]
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[2]
Carbonic anhydrase VI (CA-VI)	TTCFSPE	CAH6_HUMAN	Inhibitor	[2]
Carbonic anhydrase XII (CA-XII)	TTSYM0R	CAH12_HUMAN	Inhibitor	[2]
Carbonic anhydrase XIV (CA-XIV)	TTEYTKG	CAH14_HUMAN	Inhibitor	[2]
Casein kinase II alpha (CSNK2A1)	TTER6YH	CSK21_HUMAN	Inhibitor	[3]
Glycogen synthase kinase-3 beta (GSK-3B)	TTRSMW9	GSK3B_HUMAN	Inhibitor	[4]
Heat shock protein 70 (HSP70)	TTHYBIX	HS71A_HUMAN; HS71B_HUMAN	Inhibitor	[5]
Mothers against decapentaplegic homolog 3 (SMAD3)	TTHQZV7	SMAD3_HUMAN	Inhibitor	[5]
Squalene monooxygenase (SQLE)	TTE14XG	ERG1_HUMAN	Inhibitor	[1]
Tyrosine-protein kinase SYK (SYK)	TTOU65C	KSYK_HUMAN	Inhibitor	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
6-phosphogluconate dehydrogenase, decarboxylating (PGD)	OTVG296F	6PGD_HUMAN	Gene/Protein Processing	[6]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[7]
Achaete-scute homolog 1 (ASCL1)	OTI4X44G	ASCL1_HUMAN	Gene/Protein Processing	[8]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[9]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[7]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[7]
Apoptosis-inducing factor 1, mitochondrial (AIFM1)	OTKPWB7Q	AIFM1_HUMAN	Gene/Protein Processing	[10]
Apoptotic protease-activating factor 1 (APAF1)	OTJWIVY0	APAF_HUMAN	Gene/Protein Processing	[8]
Asparagine synthetase (ASNS)	OT8R922G	ASNS_HUMAN	Gene/Protein Processing	[8]
Autophagy protein 5 (ATG5)	OT4T5SMS	ATG5_HUMAN	Gene/Protein Processing	[8]

References

• [1] Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4.
• [2] Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164.
• [3] Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2920-3.
• [4] Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application. J Med Chem. 2006 Apr 20;49(8):2363-6.
• [5] In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.
• [6] Investigation of the effects of some phenolic compounds on the activities of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase from human erythrocytes. J Biochem Mol Toxicol. 2014 Nov;28(11):510-4. doi: 10.1002/jbt.21592. Epub 2014 Aug 6.
• [7] The effects of ellagic acid and other pomegranate (Punica granatum L.) derivatives on human gastric cancer AGS cells. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271211064534. doi: 10.1177/09603271211064534.
• [8] Interactive gene expression pattern in prostate cancer cells exposed to phenolic antioxidants. Life Sci. 2002 Mar 1;70(15):1821-39.
• [9] Ellagic acid mitigates SNO-PDI induced aggregation of Parkinsonian biomarkers. ACS Chem Neurosci. 2014 Dec 17;5(12):1209-20. doi: 10.1021/cn500214k. Epub 2014 Oct 8.
• [10] Ellagic acid induces apoptosis in TSGH8301 human bladder cancer cells through the endoplasmic reticulum stress- and mitochondria-dependent signaling pathways. Environ Toxicol. 2014 Nov;29(11):1262-74. doi: 10.1002/tox.21857. Epub 2013 Mar 30.
• [11] Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8.
• [12] Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54.
• [13] Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.
• [14] Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-r... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6.
• [15] An Antibody-Drug Conjugate Targeting MUC1-Associated Carbohydrate CA6 Shows Promising Antitumor Activities. Mol Cancer Ther. 2020 Aug;19(8):1660-1669.
• [16] Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22.
• [17] Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44.
• [18] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [19] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2597).
• [20] Understanding the Dual Inhibition of COX-2 and Carbonic Anhydrase-II by Celecoxib and CG100649 Using Density Functional Theory Calculations and other Molecular Modelling Approaches. Protein Pept Lett. 2015;22(10):903-12.
• [21] Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases. J Med Chem. 2010 Apr 8;53(7):2913-26.
• [22] Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8.
• [23] Localization of diuretic effects along the loop of Henle: an in vivo microperfusion study in rats. Clin Sci (Lond). 2000 Apr;98(4):481-8.
• [24] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [25] Selective effect of thiazides on the human osteoblast-like cell line MG-63. Kidney Int. 1996 Nov;50(5):1476-82.
• [26] Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters. J Biol Chem. 1992 Dec 15;267(35):25044-50.
• [27] Nature of the inhibition of carbonic anhydrase by acetazolamide and benzthiazide. J Pharmacol Exp Ther. 1961 Mar;131:271-4.
• [28] Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33.
• [29] Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression. Mol Pharmacol. 2006 Feb;69(2):597-607.
• [30] Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3593-6.
• [31] Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for th... Bioorg Med Chem Lett. 2008 Apr 15;18(8):2567-73.
• [32] Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mamm... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5.
• [33] Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018).Expert Opin Ther Pat. 2018 Oct;28(10):729-740.
• [34] Preparation of a Heat Shock Proteins 70-based Vaccine from DC-tumor fusion cells. Methods Mol Biol. 2011; 787: 255-265.
• [35] Mitogen-activated protein kinase kinase kinase 12 (MAP3K12; DLK); c-jun N-terminal kinase (JNK). SciBX 2(11); doi:10.1038/scibx.2009.462. March 19 2009
• [36] Company report (Multimmune)
• [37] Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
• [38] Cardiovascular effects of BRX-005 comparison to bimoclomol. Life Sci. 2000 Aug 25;67(14):1783-9.
• [39] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [40] A heat shock protein based polyvalent vaccine targeting HSV-2: CD4(+) and CD8(+) cellular immunity and protective efficacy. Vaccine. 2011 Nov 3;29(47):8530-41.
• [41] A phase I trial of intratumoral administration of recombinant oncolytic adenovirus overexpressing HSP70 in advanced solid tumor patients. Gene Ther. 2009 Mar;16(3):376-82.
• [42] Novel therapeutic targets in the management of atrial fibrillation. Am J Cardiovasc Drugs. 2014 Dec;14(6):403-21.
• [43] Bimoclomol elevates heat shock protein 70 and cytoprotects rat neonatal cardiomyocytes. Eur J Pharmacol. 2002 Jan 18;435(1):73-7.
• [44] Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. J Med Chem. 1996 Dec 20;39(26):5215-27.
• [45] 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9.
• [46] Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo. ACS Med Chem Lett. 2013 Jul 3;4(8):800-5.
• [47] Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.
• [48] CK2alpha and CK2alpha' subunits differ in their sensitivity to 4,5,6,7-tetrabromo- and 4,5,6,7-tetraiodo-1H-benzimidazole derivatives. Eur J Med Chem. 2012 Jan;47(1):345-50.
• [49] Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1149-54.
• [50] Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):573-8.
• [51] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2230).
• [52] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [53] Company report (Portola Pharmaceuticals)
• [54] J Clin Oncol 32:5s, 2014 (suppl; abstr 8580).
• [55] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [56] An open-label phase 2 trial of entospletinib (GS-9973), a selective spleen tyrosine kinase inhibitor, in chronic lymphocytic leukemia. Blood. 2015 Apr 9;125(15):2336-43.
• [57] A novel selective spleen tyrosine kinase inhibitor SKI-O-703 (cevidoplenib) ameliorates lupus nephritis and serum-induced arthritis in murine models. Clin Exp Immunol. 2023 Mar 8;211(1):31-45.
• [58] Clinical pipeline report, company report or official report of Hanmi Pharmaceutical.
• [59] The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia. Clin Cancer Res. 2017 May 1;23(9):2313-2324.
• [60] Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-assoc... Bioorg Med Chem Lett. 2004 Jan 5;14(1):217-23.
• [61] Potential role of (124)I-girentuximab in the presurgical diagnosis of clear-cell renal cell cancer. Biologics. 2012;6:395-407.
• [62] Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbo... Bioorg Med Chem Lett. 2005 Feb 1;15(3):567-71.
• [63] Therapeutic mechanism and efficacy of the antibody-drug conjugate BAY 79-4620 targeting human carbonic anhydrase 9. Mol Cancer Ther. 2012 Feb;11(2):340-9.
• [64] Application of monoclonal antibody G250 recognizing carbonic anhydrase IX in renal cell carcinoma. Int J Mol Sci. 2013 May 29;14(6):11402-23.
• [65] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [66] Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666.
• [67] The GSK3 kinase inhibitor lithium produces unexpected hyperphosphorylation of -catenin, a GSK3 substrate, in human glioblastoma cells. Biol Open. 2018 Jan 26;7(1):bio030874.
• [68] Evidence for irreversible inhibition of glycogen synthase kinase-3beta by tideglusib. J Biol Chem. 2012 Jan 6;287(2):893-904.
• [69] 9-ING-41, a small molecule inhibitor of GSK-3beta, potentiates the effects of anticancer therapeutics in bladder cancer. Sci Rep. 2019 Dec 27;9(1):19977.
• [70] Company report (Neurim Pharmaceuticals)
• [71] 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6.
• [72] Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95.
• [73] Identification of novel scaffold of benzothiazepinones as non-ATP competitive glycogen synthase kinase-3beta inhibitors through virtual screening. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7232-6.
• [74] Fragment and knowledge-based design of selective GSK-3beta inhibitors using virtual screening models. Eur J Med Chem. 2009 Jun;44(6):2361-71.
• [75] Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents. Antimicrob Agents Chemother. 1996 Feb;40(2):443-7.
• [76] Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother. 1992 Aug;36(8):1779-81.
• [77] Synthesis and biological activity of a novel squalene epoxidase inhibitor, FR194738. Bioorg Med Chem Lett. 2004 Feb 9;14(3):633-7.
• [78] Squalene epoxidase as hypocholesterolemic drug target revisited. Prog Lipid Res. 2003 Jan;42(1):37-50.
• [79] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [80] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [81] Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
• [82] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [83] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [84] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [85] Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
• [86] [Mechanisms of capsaicin-induced apoptosis of human melanoma A375-S2 cells]. Zhonghua Zhong Liu Za Zhi. 2005 Jul;27(7):401-3.
• [87] The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
• [88] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [89] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [90] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [91] Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
• [92] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
• [93] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [94] Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
• [95] Bisphenol-A and estradiol exert novel gene regulation in human MCF-7 derived breast cancer cells. Mol Cell Endocrinol. 2004 Jun 30;221(1-2):47-55. doi: 10.1016/j.mce.2004.04.010.
• [96] Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
• [97] Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
• [98] Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
• [99] Comparison of Drug Metabolism and Its Related Hepatotoxic Effects in HepaRG, Cryopreserved Human Hepatocytes, and HepG2 Cell Cultures. Biol Pharm Bull. 2018 May 1;41(5):722-732. doi: 10.1248/bpb.b17-00913. Epub 2018 Feb 14.
• [100] Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
• [101] Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
• [102] Ouabain induces apoptotic cell death in human prostate DU 145 cancer cells through DNA damage and TRAIL pathways. Environ Toxicol. 2019 Dec;34(12):1329-1339. doi: 10.1002/tox.22834. Epub 2019 Aug 21.
• [103] From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
• [104] Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
• [105] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [106] Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
• [107] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [108] Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol. Toxicol Lett. 2016 Jul 25;255:52-62.
• [109] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [110] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [111] Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20;2:55. doi: 10.1186/1755-8794-2-55.
• [112] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [113] Effects of progesterone treatment on expression of genes involved in uterine quiescence. Reprod Sci. 2011 Aug;18(8):781-97.
• [114] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
• [115] Oxidative stress in kidney transplant patients with calcineurin inhibitor-induced hypertension: effect of ramipril. J Cardiovasc Pharmacol. 2002 Oct;40(4):625-31.
• [116] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [117] Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
• [118] Antiestrogens induce transforming growth factor beta-mediated immunosuppression in breast cancer. Cancer Res. 2010 Feb 15;70(4):1314-22. doi: 10.1158/0008-5472.CAN-09-3292. Epub 2010 Feb 9.
• [119] PPAR-alpha ligands inhibit H2O2-mediated activation of transforming growth factor-beta1 in human mesangial cells. Antioxid Redox Signal. 2002 Dec;4(6):877-84. doi: 10.1089/152308602762197416.
• [120] Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
• [121] Cytokine abnormalities in a patient with eosinophilic fasciitis. Ann Allergy Asthma Immunol. 2003 Apr;90(4):452-5. doi: 10.1016/S1081-1206(10)61832-7.
• [122] Ciprofloxacin decreases survival in HT-29 cells via the induction of TGF-beta1 secretion and enhances the anti-proliferative effect of 5-fluorouracil. Br J Pharmacol. 2009 Jun;157(3):362-70. doi: 10.1111/j.1476-5381.2009.00161.x. Epub 2009 Apr 9.
• [123] Enhanced apoptosis and transforming growth factor-beta1 expression in colorectal adenomas and carcinomas after Sulindac therapy. Dis Colon Rectum. 2001 Jul;44(7):1008-15. doi: 10.1007/BF02235490.
• [124] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [125] Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
• [126] Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim Acta. 2001 Oct;312(1-2):213-9. doi: 10.1016/s0009-8981(01)00626-x.
• [127] Prostate specific antigen expression is down-regulated by selenium through disruption of androgen receptor signaling. Cancer Res. 2004 Jan 1;64(1):19-22. doi: 10.1158/0008-5472.can-03-2789.
• [128] Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells. Carcinogenesis. 2001 Mar;22(3):409-14. doi: 10.1093/carcin/22.3.409.
• [129] EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer. Oncotarget. 2015 Feb 28;6(6):3811-24.
• [130] Androgen receptor or estrogen receptor-beta blockade alters DHEA-, DHT-, and E(2)-induced proliferation and PSA production in human prostate cancer cells. Prostate. 2007 Aug 1;67(11):1152-62. doi: 10.1002/pros.20585.
• [131] Nevirapine restores androgen signaling in hormone-refractory human prostate carcinoma cells both in vitro and in vivo. Prostate. 2009 May 15;69(7):744-54. doi: 10.1002/pros.20923.
• [132] An open-label phase II study of low-dose thalidomide in androgen-independent prostate cancer. Br J Cancer. 2003 Mar 24;88(6):822-7. doi: 10.1038/sj.bjc.6600817.
• [133] Inhibition of 5alpha-reductase enhances testosterone-induced expression of U19/Eaf2 tumor suppressor during the regrowth of LNCaP xenograft tumor in nude mice. Prostate. 2010 Oct 1;70(14):1575-85. doi: 10.1002/pros.21193.
• [134] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [135] Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
• [136] A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
• [137] Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
• [138] Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
• [139] Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
• [140] Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci. 2007 Mar;96(1):101-14.
• [141] Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
• [142] Quercetin reduces oxidative damage induced by paraquat via modulating expression of antioxidant genes in A549 cells. J Appl Toxicol. 2013 Dec;33(12):1460-7. doi: 10.1002/jat.2812. Epub 2012 Sep 20.
• [143] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
• [144] A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
• [145] Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
• [146] Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.
• [147] Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
• [148] Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):117-27.
• [149] Natural antioxidants exhibit chemopreventive characteristics through the regulation of CNC b-Zip transcription factors in estrogen-induced breast carcinogenesis. J Biochem Mol Toxicol. 2014 Dec;28(12):529-38.
• [150] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
• [151] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [152] Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
• [153] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [154] Thalidomide and Its Analogs Differentially Target Fibroblast Growth Factor Receptors: Thalidomide Suppresses FGFR Gene Expression while Pomalidomide Dampens FGFR2 Activity. Chem Res Toxicol. 2019 Apr 15;32(4):589-602. doi: 10.1021/acs.chemrestox.8b00286. Epub 2019 Mar 15.
• [155] The mutant androgen receptor T877A mediates the proliferative but not the cytotoxic dose-dependent effects of genistein and quercetin on human LNCaP prostate cancer cells. Mol Pharmacol. 2002 Nov;62(5):1027-35. doi: 10.1124/mol.62.5.1027.
• [156] THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
• [157] Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
• [158] The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
• [159] Metronomic gemcitabine suppresses tumour growth, improves perfusion, and reduces hypoxia in human pancreatic ductal adenocarcinoma. Br J Cancer. 2010 Jun 29;103(1):52-60.
• [160] Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
• [161] Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
• [162] Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4578-83.
• [163] DHT and testosterone, but not DHEA or E2, differentially modulate IGF-I, IGFBP-2, and IGFBP-3 in human prostatic stromal cells. Am J Physiol Endocrinol Metab. 2006 May;290(5):E952-60. doi: 10.1152/ajpendo.00451.2005. Epub 2005 Dec 20.
• [164] Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
• [165] Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
• [166] Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
• [167] Identification of novel activators of the metal responsive transcription factor (MTF-1) using a gene expression biomarker in a microarray compendium. Metallomics. 2020 Sep 23;12(9):1400-1415. doi: 10.1039/d0mt00071j.
• [168] Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
• [169] Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
• [170] Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
• [171] Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
• [172] Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse. Pharmacogenomics J. 2003;3(1):27-40.
• [173] Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis. Biol Reprod. 2011 Apr;84(4):801-15.
• [174] Specific molecular interactions of oversulfated chondroitin sulfate E with various heparin-binding growth factors. Implications as a physiological binding partner in the brain and other tissues. J Biol Chem. 2002 Nov 15;277(46):43707-16. doi: 10.1074/jbc.M207105200. Epub 2002 Sep 6.
• [175] Filamin A phosphorylation by Akt promotes cell migration in response to arsenic. Oncotarget. 2015 May 20;6(14):12009-19. doi: 10.18632/oncotarget.3617.
• [176] Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
• [177] Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake. Obesity (Silver Spring). 2010 Jan;18(1):27-34. doi: 10.1038/oby.2009.208. Epub 2009 Jun 25.
• [178] An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
• [179] Human oligodendrocytes derived from embryonic stem cells: Effect of noggin on phenotypic differentiation in vitro and on myelination in vivo. Mol Cell Neurosci. 2007 Mar;34(3):310-23. doi: 10.1016/j.mcn.2006.11.008. Epub 2006 Dec 28.
• [180] 2,3,7,8-tetrachlorodibenzo-p-dioxin augments the modulation of gene expression mediated by the thyroid hormone receptor. Toxicol Appl Pharmacol. 2004 Feb 1;194(3):201-10. doi: 10.1016/j.taap.2003.09.010.
• [181] Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
• [182] Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
• [183] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [184] Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
• [185] Curcumin reduces the expression of survivin, leading to enhancement of arsenic trioxide-induced apoptosis in myelodysplastic syndrome and leukemia stem-like cells. Oncol Rep. 2016 Sep;36(3):1233-42. doi: 10.3892/or.2016.4944. Epub 2016 Jul 15.
• [186] Effects of Imatinib Mesylate (Gleevec) on human islet NF-kappaB activation and chemokine production in vitro. PLoS One. 2011;6(9):e24831. doi: 10.1371/journal.pone.0024831. Epub 2011 Sep 14.
• [187] Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
• [188] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [189] Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
• [190] Valproic acid promotes mitochondrial dysfunction in primary human hepatocytes in vitro; impact of C/EBP-controlled gene expression. Arch Toxicol. 2020 Oct;94(10):3463-3473. doi: 10.1007/s00204-020-02835-x. Epub 2020 Jul 4.
• [191] Role of oxidative stress in the induction of metallothionein-2A and heme oxygenase-1 gene expression by the antineoplastic agent gallium nitrate in human lymphoma cells. Free Radic Biol Med. 2008 Sep 15;45(6):763-72.
• [192] Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
• [193] Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
• [194] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [195] Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134. doi: 10.1016/j.envres.2019.03.035. Epub 2019 Mar 18.
• [196] Differential gene expression of sulindac-treated human breast epithelial cells. Int J Oncol. 2005 Dec;27(6):1727-36.
• [197] Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
• [198] Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
• [199] Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia. Blood. 2010 Jan 14;115(2):326-30. doi: 10.1182/blood-2009-07-235051. Epub 2009 Nov 2.
• [200] Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol Rep. 2006 Jun;15(6):1453-60.
• [201] Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
• [202] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
• [203] Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
• [204] [Mechanisms underlying the effect of arsenic trioxide on proliferation inhibition and apoptosis induction in myeloma cell line u266]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Oct;15(5):982-5.
• [205] Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
• [206] Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
• [207] Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
• [208] Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
• [209] Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
• [210] Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
• [211] mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
• [212] Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
• [213] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [214] Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
• [215] 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
• [216] Resveratrol induces Notch2-mediated apoptosis and suppression of neuroendocrine markers in medullary thyroid cancer. Ann Surg Oncol. 2011 May;18(5):1506-11. doi: 10.1245/s10434-010-1488-z. Epub 2010 Dec 24.
• [217] Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators. Mol Endocrinol. 2010 Jan;24(1):33-46.
• [218] Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
• [219] Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease. Proteomics. 2008 Apr;8(8):1595-607. doi: 10.1002/pmic.200700556.
• [220] Rosiglitazone sensitizes MDA-MB-231 breast cancer cells to anti-tumour effects of tumour necrosis factor-alpha, CH11 and CYC202. Endocr Relat Cancer. 2007 Jun;14(2):305-15. doi: 10.1677/ERC-06-0003.
• [221] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [222] Gene alterations of ovarian cancer cells expressing estrogen receptors by estrogen and bisphenol a using microarray analysis. Lab Anim Res. 2011 Jun;27(2):99-107. doi: 10.5625/lar.2011.27.2.99. Epub 2011 Jun 22.
• [223] Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
• [224] Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
• [225] The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. Hum Reprod. 2010 Nov;25(11):2859-69.
• [226] Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
• [227] Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
• [228] Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49. doi: 10.1016/j.placenta.2019.10.008. Epub 2019 Oct 17.
• [229] Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
• [230] Trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence. J Nat Prod. 2013 Jul 26;76(7):1242-7.
• [231] Quercetin induces the expression of peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway. Invest Ophthalmol Vis Sci. 2011 Feb 22;52(2):1055-63. doi: 10.1167/iovs.10-5777.
• [232] Troglitazone induces cytotoxicity in part by promoting the degradation of peroxisome proliferator-activated receptor co-activator-1 protein. Br J Pharmacol. 2010 Oct;161(4):771-81. doi: 10.1111/j.1476-5381.2010.00900.x.
• [233] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [234] Plasmatic concentration of organochlorine lindane acts as metabolic disruptors in HepG2 liver cell line by inducing mitochondrial disorder. Toxicol Appl Pharmacol. 2013 Oct 15;272(2):325-34.
• [235] The effect of ethidium bromide and chloramphenicol on mitochondrial biogenesis in primary human fibroblasts. Toxicol Appl Pharmacol. 2012 May 15;261(1):42-9. doi: 10.1016/j.taap.2012.03.009.
• [236] Deficiency of the human mitochondrial transcription factor h-mtTFA in infantile mitochondrial myopathy is associated with mtDNA depletion. Hum Mol Genet. 1994 Oct;3(10):1763-9. doi: 10.1093/hmg/3.10.1763.
• [237] PPARgama activation rescues mitochondrial function from inhibition of complex I and loss of PINK1. Exp Neurol. 2014 Mar;253:16-27.
• [238] Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
• [239] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [240] MiR-146a affects the alteration in myeloid differentiation induced by hydroquinone in human CD34(+) hematopoietic progenitor cells and HL-60 cells. Toxicol Res (Camb). 2016 Feb 16;5(3):848-858. doi: 10.1039/c5tx00419e. eCollection 2016 May 1.
• [241] Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
• [242] Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
• [243] White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol. 2015 Jan;17(1):57-67. doi: 10.1038/ncb3075. Epub 2014 Dec 8.
• [244] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [245] Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
• [246] Functional characterization of peroxisome proliferator-activated receptor-/ expression in colon cancer. Mol Carcinog. 2011 Nov;50(11):884-900. doi: 10.1002/mc.20757. Epub 2011 Mar 11.
• [247] Aspirin-induced apoptosis in jurkat cells is not mediated by peroxisome proliferator-activated receptor delta. Mol Cell Biochem. 2004 Nov;266(1-2):57-63. doi: 10.1023/b:mcbi.0000049138.67699.7b.
• [248] Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
• [249] (9)-Tetrahydrocannabinol upregulates fatty acid 2-hydroxylase (FA2H) via PPAR induction: A possible evidence for the cancellation of PPAR/-mediated inhibition of PPAR in MDA-MB-231?cells. Arch Biochem Biophys. 2019 Feb 15;662:219-225. doi: 10.1016/j.abb.2018.12.011. Epub 2018 Dec 13.
• [250] Cross-talk between vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling in melanoma cells. Anticancer Res. 2009 Sep;29(9):3647-58.
• [251] -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
• [252] Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2716-23.
• [253] Prevention of deoxycholate-induced gastric apoptosis by aspirin: roles of NF-kappaB and PKC signaling. J Surg Res. 2008 Mar;145(1):66-73. doi: 10.1016/j.jss.2007.04.039. Epub 2007 Jul 20.
• [254] Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells. Immunology. 2007 May;121(1):71-81. doi: 10.1111/j.1365-2567.2006.02539.x.
• [255] Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells. Eur J Pharmacol. 2010 Jun 10;635(1-3):219-26. doi: 10.1016/j.ejphar.2010.02.044. Epub 2010 Mar 20.
• [256] The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
• [257] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [258] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
• [259] Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
• [260] Using a customized DNA microarray for expression profiling of the estrogen-responsive genes to evaluate estrogen activity among natural estrogens and industrial chemicals. Environ Health Perspect. 2004 May;112(7):773-81. doi: 10.1289/ehp.6753.
• [261] Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
• [262] Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars. J Trauma. 2004 Nov;57(5):1032-7. doi: 10.1097/01.ta.0000114087.46566.eb.
• [263] Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells. J Biol Chem. 2017 Feb 17;292(7):2815-2829. doi: 10.1074/jbc.M116.745398. Epub 2017 Jan 4.
• [264] Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.
• [265] NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
• [266] Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
• [267] Effects of aspirin on metastasis-associated gene expression detected by cDNA microarray. Acta Pharmacol Sin. 2004 Oct;25(10):1327-33.
• [268] LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
• [269] Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
• [270] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
• [271] Genome-wide association for methamphetamine dependence: convergent results from 2 samples. Arch Gen Psychiatry. 2008 Mar;65(3):345-55. doi: 10.1001/archpsyc.65.3.345.
• [272] Cyclic GMP-dependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells. J Pharmacol Exp Ther. 2001 Nov;299(2):583-92.
• [273] Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int. 2021 Nov;156:106730. doi: 10.1016/j.envint.2021.106730. Epub 2021 Jun 27.
• [274] Adaptive changes in global gene expression profile of lung carcinoma A549 cells acutely exposed to distinct types of AhR ligands. Toxicol Lett. 2018 Aug;292:162-174.
• [275] Evaluation of an in vitro model of androgen ablation and identification of the androgen responsive proteome in LNCaP cells. Proteomics. 2007 Jan;7(1):47-63.
• [276] Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
• [277] Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
• [278] Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
• [279] Gene expression changes associated with altered growth and differentiation in benzo[a]pyrene or arsenic exposed normal human epidermal keratinocytes. J Appl Toxicol. 2008 May;28(4):491-508.
• [280] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [281] Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
• [282] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [283] Effects of valproic acid on gene expression during human embryonic stem cell differentiation into neurons. J Toxicol Sci. 2014 Jun;39(3):383-90. doi: 10.2131/jts.39.383.
• [284] Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
• [285] Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
• [286] Lidocaine prevents breast cancer growth by targeting neuronatin to inhibit nerve fibers formation. J Toxicol Sci. 2021;46(7):329-339. doi: 10.2131/jts.46.329.
• [287] High expressions of neuronatin isoforms in favorable neuroblastoma. J Pediatr Hematol Oncol. 2007 Aug;29(8):551-6. doi: 10.1097/MPH.0b013e3181256b7b.
• [288] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [289] Cannabidiol disrupts apoptosis, autophagy and invasion processes of placental trophoblasts. Arch Toxicol. 2021 Oct;95(10):3393-3406. doi: 10.1007/s00204-021-03122-z. Epub 2021 Jul 24.
• [290] AMP-activated protein kinase activity is required for vanadate-induced hypoxia-inducible factor 1alpha expression in DU145 cells. Carcinogenesis. 2004 Dec;25(12):2497-507. doi: 10.1093/carcin/bgh253. Epub 2004 Aug 5.
• [291] Identification of chemical compounds that induce HIF-1alpha activity. Toxicol Sci. 2009 Nov;112(1):153-63.
• [292] NO-sulindac inhibits the hypoxia response of PC-3 prostate cancer cells via the Akt signalling pathway. Int J Cancer. 2009 Jan 1;124(1):223-32. doi: 10.1002/ijc.23934.
• [293] Simvastatin stimulates vascular endothelial growth factor production by hypoxia-inducible factor-1alpha upregulation in endothelial cells. J Cardiovasc Pharmacol. 2008 Mar;51(3):267-73. doi: 10.1097/FJC.0b013e3181624b44.
• [294] Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism. Chem Biol Interact. 2023 Jan 5;369:110278. doi: 10.1016/j.cbi.2022.110278. Epub 2022 Nov 22.
• [295] Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
• [296] Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
• [297] SU5416 inhibited VEGF and HIF-1alpha expression through the PI3K/AKT/p70S6K1 signaling pathway. Biochem Biophys Res Commun. 2004 Nov 12;324(2):471-80. doi: 10.1016/j.bbrc.2004.09.082.
• [298] E4F1 silencing inhibits the cell growth through cell-cycle arrest in malignant transformed cells induced by hydroquinone. J Biochem Mol Toxicol. 2019 Apr;33(4):e22269. doi: 10.1002/jbt.22269. Epub 2018 Dec 1.
• [299] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
• [300] Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
• [301] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [302] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [303] Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
• [304] Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
• [305] The significance of Runx2 mediating alcohol-induced Brf1 expression and RNA Pol III gene transcription. Chem Biol Interact. 2020 May 25;323:109057. doi: 10.1016/j.cbi.2020.109057. Epub 2020 Mar 18.
• [306] Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
• [307] Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
• [308] Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
• [309] Nicotine modulates the expression of a diverse set of genes in the neuronal SH-SY5Y cell line. J Biol Chem. 2003 May 2;278(18):15633-40.
• [310] Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006 Jan 10;24(2):274-87. doi: 10.1200/JCO.2005.02.9405. Epub 2005 Dec 19.
• [311] Patterns of gene expressions induced by arsenic trioxide in cultured human fibroblasts. Toxicol Lett. 2003 Jul 20;143(2):155-62. doi: 10.1016/s0378-4274(03)00171-1.
• [312] Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
• [313] A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
• [314] EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS One. 2011;6(6):e18691. doi: 10.1371/journal.pone.0018691. Epub 2011 Jun 2.
• [315] Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy. Oxid Med Cell Longev. 2018 Mar 18;2018:1482795. doi: 10.1155/2018/1482795. eCollection 2018.
• [316] Arsenic trioxide induces autophagic cell death in osteosarcoma cells via the ROS-TFEB signaling pathway. Biochem Biophys Res Commun. 2018 Jan 29;496(1):167-175. doi: 10.1016/j.bbrc.2018.01.018. Epub 2018 Jan 4.
• [317] TNF enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy. Toxicol Lett. 2021 May 15;342:73-84. doi: 10.1016/j.toxlet.2021.02.009. Epub 2021 Feb 17.
• [318] Inhibition of autophagy enhances Hydroquinone-induced TK6 cell death. Toxicol In Vitro. 2017 Jun;41:123-132. doi: 10.1016/j.tiv.2017.02.024. Epub 2017 Mar 2.
• [319] AMPK activation induced by promethazine increases NOXA expression and Beclin-1 phosphorylation and drives autophagy-associated apoptosis in chronic myeloid leukemia. Chem Biol Interact. 2020 Jan 5;315:108888. doi: 10.1016/j.cbi.2019.108888. Epub 2019 Nov 2.
• [320] Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe. 2009 Sep 17;6(3):231-43. doi: 10.1016/j.chom.2009.08.004.
• [321] 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
• [322] Daxx is a transcriptional repressor of CCAAT/enhancer-binding protein beta. J Biol Chem. 2009 Oct 16;284(42):28783-94. doi: 10.1074/jbc.M109.041186. Epub 2009 Aug 18.
• [323] Synergistic effects of iron and aluminum on stress-related gene expression in primary human neural cells. J Alzheimers Dis. 2005 Nov;8(2):117-27; discussion 209-15. doi: 10.3233/jad-2005-8204.
• [324] Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation. Biochem Pharmacol. 2003 Sep 1;66(5):711-24. doi: 10.1016/s0006-2952(03)00410-6.
• [325] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [326] Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
• [327] Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells. Neurosci Lett. 2006 Mar 13;395(3):185-90. doi: 10.1016/j.neulet.2005.10.096. Epub 2005 Dec 1.
• [328] Effects of four-week high-fructose diet on gene expression in skeletal muscle of healthy men. Diabetes Metab. 2008 Feb;34(1):82-5. doi: 10.1016/j.diabet.2007.08.004. Epub 2007 Dec 11.
• [329] ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
• [330] Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
• [331] Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
• [332] (9)-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7-Stimulated Human Coculture. J Pharmacol Exp Ther. 2019 Oct;371(1):191-201. doi: 10.1124/jpet.119.260661. Epub 2019 Aug 5.
• [333] Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
• [334] Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. Arch Toxicol. 2018 Jun;92(6):2043-2054. doi: 10.1007/s00204-018-2199-7. Epub 2018 Mar 29.
• [335] Spironolactone induces apoptosis in human mononuclear cells. Association between apoptosis and cytokine suppression. Apoptosis. 2006 Apr;11(4):573-9. doi: 10.1007/s10495-006-4919-3.
• [336] Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42.
• [337] Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
• [338] Anti-androgenic effect of 6-formylindolo[3,2-b]carbazole (FICZ) in LNCaP cells is mediated by the aryl hydrocarbon-androgen receptors cross-talk. Steroids. 2020 Jan;153:108508. doi: 10.1016/j.steroids.2019.108508. Epub 2019 Oct 3.
• [339] Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition. Arch Toxicol. 2008 Dec;82(12):909-21.
• [340] Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density. J Bone Miner Res. 2005 Feb;20(2):232-9. doi: 10.1359/JBMR.041110. Epub 2004 Nov 16.
• [341] Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
• [342] Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 1999 Feb 1;59(3):607-14.
• [343] Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
• [344] The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol. Arch Toxicol. 2013 Apr;87(4):633-43.
• [345] Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Gastroenterology. 2004 Nov;127(5):1436-45.
• [346] Real-time PCR analysis of the apoptosis related genes in ATRA treated APL t(15;17) patients. Exp Mol Med. 2003 Oct 31;35(5):454-9. doi: 10.1038/emm.2003.59.
• [347] Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
• [348] Epigenetic activation of O-linked -N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia. EBioMedicine. 2020 Apr;54:102678. doi: 10.1016/j.ebiom.2020.102678. Epub 2020 Apr 6.
• [349] Histamine downregulates CD14 expression via H2 receptors on human monocytes. Clin Immunol. 2003 Sep;108(3):274-81. doi: 10.1016/s1521-6616(03)00140-2.
• [350] The anti-proliferative effect of calcitriol on HL-60 cells is neutralized by uraemic biological fluids. Nephrol Dial Transplant. 2001 Feb;16(2):246-52. doi: 10.1093/ndt/16.2.246.
• [351] Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
• [352] Crosstalk between alveolar macrophages and alveolar epithelial cells/fibroblasts contributes to the pulmonary toxicity of gefitinib. Toxicol Lett. 2021 Mar 1;338:1-9. doi: 10.1016/j.toxlet.2020.11.011. Epub 2020 Nov 25.
• [353] Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
• [354] Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
• [355] Dimethyl Fumarate Inhibits the Nuclear Factor B Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. J Biol Chem. 2016 Feb 12;291(7):3639-47. doi: 10.1074/jbc.M115.679704. Epub 2015 Dec 18.
• [356] Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients. Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1194-9. doi: 10.1161/01.atv.0000022694.16328.cc.
• [357] Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFB and AhR and EGFR-ERK pathway. Toxicol Appl Pharmacol. 2011 Sep 1;255(2):138-49.
• [358] Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium. Chem Biol Interact. 2010 Dec 5;188(3):659-67.
• [359] Differential expression of secretory phospholipases A2 in normal and malignant prostate cell lines: regulation by cytokines, cell signaling pathways, and epigenetic mechanisms. Neoplasia. 2008 Mar;10(3):279-86. doi: 10.1593/neo.07965.
• [360] Circulating endothelial progenitor cells in multiple myeloma: implications and significance. Blood. 2005 Apr 15;105(8):3286-94. doi: 10.1182/blood-2004-06-2101. Epub 2004 Dec 23.
• [361] Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression. Eur Neuropsychopharmacol. 2007 Dec;17(12):774-80.
• [362] Diesel exhaust particulate-induced activation of Stat3 requires activities of EGFR and Src in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2007 Feb;292(2):L422-9. doi: 10.1152/ajplung.00204.2006. Epub 2006 Oct 6.
• [363] Physapubescin B enhances the sensitivity of gastric cancer cells to trametinib by inhibiting the STAT3 signaling pathway. Toxicol Appl Pharmacol. 2020 Dec 1;408:115273. doi: 10.1016/j.taap.2020.115273. Epub 2020 Oct 6.
• [364] Sulindac induces apoptosis and inhibits tumor growth in vivo in head and neck squamous cell carcinoma. Neoplasia. 2007 Mar;9(3):192-9. doi: 10.1593/neo.06781.
• [365] Simvastatin acts as an inhibitor of interferon gamma-induced cycloxygenase-2 expression in human THP-1 cells, but not in murine RAW264.7 cells. Biocell. 2009 Aug;33(2):107-14.
• [366] Therapeutic potential of cladribine in combination with STAT3 inhibitor against multiple myeloma. BMC Cancer. 2011 Jun 16;11:255. doi: 10.1186/1471-2407-11-255.
• [367] Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling. Biochem Pharmacol. 2014 Feb 1;87(3):424-34. doi: 10.1016/j.bcp.2013.11.008. Epub 2013 Nov 23.
• [368] Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
• [369] Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
• [370] Protective role of HO-1 for alcohol-dependent liver damage. Dig Dis. 2010;28(6):792-8. doi: 10.1159/000324287. Epub 2011 Apr 27.
• [371] Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
• [372] High selenium status in individuals exposed to arsenic through coal-burning in Shaanxi (PR of China) modulates antioxidant enzymes, heme oxygenase-1 and DNA damage. Clin Chim Acta. 2010 Sep 6;411(17-18):1312-8.
• [373] Combination treatment with arsenic trioxide and sulindac enhances apoptotic cell death in lung cancer cells via activation of oxidative stress and mitogen-activated protein kinases. Oncol Rep. 2008 Aug;20(2):379-84.
• [374] Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
• [375] Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes. Arch Toxicol. 2018 Jan;92(1):371-381.
• [376] Enhanced cytotoxicity of bioreductive antitumor agents with dimethyl fumarate in human glioblastoma cells. Anticancer Drugs. 2005 Feb;16(2):167-74.
• [377] Growth-suppressive effect of non-steroidal anti-inflammatory drugs on 11 colon-cancer cell lines and fluorescence differential display of genes whose expression is influenced by sulindac. Int J Cancer. 2000 Dec 15;88(6):873-80. doi: 10.1002/1097-0215(20001215)88:6<873::aid-ijc6>3.0.co;2-b.
• [378] Simvastatin protects dopaminergic neurons against MPP+-induced oxidative stress and regulates the endogenous anti-oxidant system through ERK. Cell Physiol Biochem. 2018;51(4):1957-1968.
• [379] P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
• [380] Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin. Toxicol Lett. 2001 Feb 3;119(1):49-57.
• [381] Effect of ellagic acid on the expression of human telomerase reverse transcriptase (hTERT) alpha+beta+ transcript in estrogen receptor-positive MCF-7 breast cancer cells. Clin Biochem. 2009 Sep;42(13-14):1358-62. doi: 10.1016/j.clinbiochem.2009.05.017. Epub 2009 Jun 6.
• [382] Antiproliferative effects of gefitinib are associated with suppression of E2F-1 expression and telomerase activity. Anticancer Res. 2006 Sep-Oct;26(5A):3387-91.
• [383] Inhibitory effects of selenium on telomerase activity and hTERT expression in cadmium-transformed 16HBE cells. Biomed Environ Sci. 2007 Aug;20(4):307-12.
• [384] Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast cancer cells. BMC Cancer. 2010 Jul 22;10:390. doi: 10.1186/1471-2407-10-390.
• [385] Analysis of telomerase activity and RNA expression in a patient with acute promyelocytic leukemia treated with all-trans retinoic acid. Pediatr Blood Cancer. 2006 Apr;46(4):506-11. doi: 10.1002/pbc.20392.
• [386] Characterization of the functional and growth properties of long-term cell cultures established from a human somatostatinoma. Endocr Relat Cancer. 2006 Mar;13(1):79-93. doi: 10.1677/erc.1.00988.
• [387] Characterization of arsenic-induced cytogenetic alterations in acute promyelocytic leukemia cell line, NB4. Med Oncol. 2012 Jun;29(2):1209-16. doi: 10.1007/s12032-011-9946-4. Epub 2011 May 5.
• [388] Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
• [389] Sulindac activates nuclear translocation of AIF, DFF40 and endonuclease G but not induces oligonucleosomal DNA fragmentation in HT-29 cells. Life Sci. 2005 Sep 2;77(16):2059-70. doi: 10.1016/j.lfs.2005.04.021.
• [390] Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
• [391] Arsenic trioxide-induced death of neuroblastoma cells involves activation of Bax and does not require p53. Clin Cancer Res. 2004 May 1;10(9):3179-88. doi: 10.1158/1078-0432.ccr-03-0309.
• [392] Clonidine Induces Apoptosis of Human Corneal Epithelial Cells through Death Receptors-Mediated, Mitochondria-Dependent Signaling Pathway. Toxicol Sci. 2017 Mar 1;156(1):252-260. doi: 10.1093/toxsci/kfw249.
• [393] Emetine inhibits migration and invasion of human non-small-cell lung cancer cells via regulation of ERK and p38 signaling pathways. Chem Biol Interact. 2015 Dec 5;242:25-33. doi: 10.1016/j.cbi.2015.08.014. Epub 2015 Aug 30.
• [394] Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
• [395] Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
• [396] Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling. Int J Cancer. 2004 Nov 1;112(2):200-12. doi: 10.1002/ijc.20401.
• [397] The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel. BMC Med Genomics. 2010 Aug 13;3:37. doi: 10.1186/1755-8794-3-37.
• [398] Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells. J Biochem Mol Toxicol. 2020 Feb;34(2):e22433. doi: 10.1002/jbt.22433. Epub 2020 Jan 9.
• [399] A cell impedance-based real-time in vitro assay to assess the toxicity of amphotericin B formulations. Toxicol Appl Pharmacol. 2017 Nov 1;334:18-23. doi: 10.1016/j.taap.2017.08.017. Epub 2017 Sep 1.
• [400] CBD Promotes Oral Ulcer Healing via Inhibiting CMPK2-Mediated Inflammasome. J Dent Res. 2022 Feb;101(2):206-215. doi: 10.1177/00220345211024528. Epub 2021 Jul 16.
• [401] Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
• [402] Anti-inflammatory effects of the GABA(B) receptor agonist baclofen in allergic contact dermatitis. Exp Dermatol. 2010 Jul 1;19(7):661-6. doi: 10.1111/j.1600-0625.2010.01076.x. Epub 2010 Feb 25.
• [403] Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways. World J Gastrointest Oncol. 2022 Feb 15;14(2):450-477. doi: 10.4251/wjgo.v14.i2.450.
• [404] Sulfasalazine unveils a contact-independent HSV-TK/ganciclovir gene therapy bystander effect in malignant gliomas. Int J Oncol. 2007 Jan;30(1):283-90.
• [405] A protein-coated magnetic beads as a tool for the rapid drug-protein binding study. J Pharm Biomed Anal. 2010 Jul 8;52(3):420-4. doi: 10.1016/j.jpba.2009.06.023. Epub 2009 Jun 18.
• [406] The three recombinant domains of human serum albumin. Structural characterization and ligand binding properties. J Biol Chem. 1999 Oct 8;274(41):29303-10. doi: 10.1074/jbc.274.41.29303.
• [407] Exploring binding properties of sertraline with human serum albumin: Combination of spectroscopic and molecular modeling studies. Chem Biol Interact. 2015 Dec 5;242:235-46. doi: 10.1016/j.cbi.2015.10.006. Epub 2015 Oct 22.
• [408] Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
• [409] Use of peak decay analysis and affinity microcolumns containing silica monoliths for rapid determination of drug-protein dissociation rates. J Chromatogr A. 2011 Apr 15;1218(15):2072-8. doi: 10.1016/j.chroma.2010.09.070. Epub 2010 Oct 16.
• [410] [Colchicine in chronic liver disease of alcoholic etiology. Double-blind, randomized study of its effects on blood levels of plasma proteins and clinical course in patients]. Rev Assoc Med Bras (1992). 1995 May-Jun;41(3):207-12.
• [411] Editor's Highlight: Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues. Toxicol Sci. 2016 Dec;154(2):354-367. doi: 10.1093/toxsci/kfw169. Epub 2016 Sep 7.
• [412] Covalent binding of the flavonoid quercetin to human serum albumin. J Agric Food Chem. 2005 May 18;53(10):4194-7. doi: 10.1021/jf050061m.
• [413] p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
• [414] Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
• [415] Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
• [416] Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
• [417] Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. Nucleic Acids Res. 2009 Jan;37(1):78-95. doi: 10.1093/nar/gkn910. Epub 2008 Nov 16.
• [418] Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
• [419] Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
• [420] Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
• [421] High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells. Blood. 1993 Nov 15;82(10):3133-40.
• [422] Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples. Data Brief. 2016 Mar 26;7:1052-1057. doi: 10.1016/j.dib.2016.03.069. eCollection 2016 Jun.
• [423] Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
• [424] Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
• [425] Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
• [426] Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem. 2002 Nov 15;277(46):43648-58. doi: 10.1074/jbc.M203214200. Epub 2002 Sep 6.
• [427] [Regulation mechanism of autophagy-related protein LC3 by c-Jun in methotrexate resistant human choriocarcinoma JEG-3 cells]. Zhonghua Fu Chan Ke Za Zhi. 2014 Jul;49(7):531-5.
• [428] Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
• [429] G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J Biol Chem. 1993 Apr 15;268(11):8298-308.
• [430] mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
• [431] Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
• [432] Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
• [433] Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
• [434] Oxidative Stress-Protective and Anti-Melanogenic Effects of Loliolide and Ethanol Extract from Fresh Water Green Algae, Prasiola japonica. Int J Mol Sci. 2018 Sep 18;19(9):2825. doi: 10.3390/ijms19092825.
• [435] Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
• [436] Impaired migration of trophoblast cells caused by simvastatin is associated with decreased membrane IGF-I receptor, MMP2 activity and HSP27 expression. Hum Reprod. 2007 Apr;22(4):1161-7. doi: 10.1093/humrep/del464. Epub 2006 Dec 11.
• [437] Quercetin Suppresses the Migration and Invasion in Human Colon Cancer Caco-2 Cells Through Regulating Toll-like Receptor 4/Nuclear Factor-kappa B Pathway. Pharmacogn Mag. 2016 May;12(Suppl 2):S237-44. doi: 10.4103/0973-1296.182154. Epub 2016 May 11.
• [438] Troglitazone but not conjugated linoleic acid reduces gene expression and activity of matrix-metalloproteinases-2 and -9 in PMA-differentiated THP-1 macrophages. J Nutr Biochem. 2008 Sep;19(9):594-603. doi: 10.1016/j.jnutbio.2007.08.003. Epub 2007 Dec 21.
• [439] Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation. Mol Cell Endocrinol. 2012 Jan 2;348(1):260-9. doi: 10.1016/j.mce.2011.09.002. Epub 2011 Sep 6.
• [440] Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: role of nuclear factor-kappaB and reactive oxygen species. J Cell Biochem. 2005 Aug 1;95(5):955-69. doi: 10.1002/jcb.20452.
• [441] Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes. Pharmacology. 2009;83(1):18-25. doi: 10.1159/000166183. Epub 2008 Oct 30.
• [442] Repetitive nonlethal oxidant injury to retinal pigment epithelium decreased extracellular matrix turnover in vitro and induced sub-RPE deposits in vivo. Invest Ophthalmol Vis Sci. 2006 Sep;47(9):4098-112. doi: 10.1167/iovs.05-1230.
• [443] Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
• [444] Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol. 2012 May;57(5):483-90. doi: 10.1016/j.archoralbio.2011.10.007. Epub 2011 Nov 25.
• [445] Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
• [446] Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med. 2000 Jan;161(1):249-56. doi: 10.1164/ajrccm.161.1.9804096.
• [447] Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
• [448] Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
• [449] Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
• [450] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
• [451] Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
• [452] Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
• [453] Comparison of characteristics of peroxide-conditioned immortal human lens-epithelial cell lines with their murine counterparts. Exp Eye Res. 2004 Sep;79(3):411-7.
• [454] Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
• [455] Isoniazid-induced apoptosis in HepG2 cells: generation of oxidative stress and Bcl-2 down-regulation. Toxicol Mech Methods. 2010 Jun;20(5):242-51. doi: 10.3109/15376511003793325.
• [456] Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment. Pharmaceutics. 2021 Sep 7;13(9):1415. doi: 10.3390/pharmaceutics13091415.
• [457] Pentosan polysulfate decreases proliferation and extracellular matrix deposition by vascular smooth muscle cells isolated from failed hemodialysis access grafts. Clin Nephrol. 2000 Aug;54(2):121-7.
• [458] Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
• [459] Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
• [460] Matrix metalloproteinase-9 is involved in chronic lymphocytic leukemia cell response to fludarabine and arsenic trioxide. PLoS One. 2014 Jun 23;9(6):e99993. doi: 10.1371/journal.pone.0099993. eCollection 2014.
• [461] Simvastatin, an HMG-CoA reductase inhibitor, reduced the expression of matrix metalloproteinase-9 (Gelatinase B) in osteoblastic cells and HT1080 fibrosarcoma cells. J Pharmacol Sci. 2004 Apr;94(4):403-9. doi: 10.1254/jphs.94.403.
• [462] Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
• [463] Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. Mol Cancer. 2010 Aug 20;9:220.
• [464] Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway. J Biochem Mol Toxicol. 2023 Jun;37(6):e23328. doi: 10.1002/jbt.23328. Epub 2023 Feb 19.
• [465] Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
• [466] Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2015 Mar;35(3):1063-76. doi: 10.1111/liv.12626. Epub 2014 Jul 30.
• [467] Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
• [468] Development of an alternative zebrafish model for drug-induced intestinal toxicity. J Appl Toxicol. 2018 Feb;38(2):259-273. doi: 10.1002/jat.3520. Epub 2017 Oct 13.
• [469] The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. Exp Eye Res. 2010 Jul;91(1):15-25.
• [470] Gaseous nitrogen oxide promotes human lung cancer cell line A549 migration, invasion, and metastasis via iNOS-mediated MMP-2 production. Toxicol Sci. 2008 Dec;106(2):364-75. doi: 10.1093/toxsci/kfn195. Epub 2008 Sep 16.
• [471] Mechanism of simvastatin-induced K562 cell apoptosis. Pharmacology. 2009;84(4):191-5. doi: 10.1159/000235907. Epub 2009 Sep 2.
• [472] The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells. Eur J Pharmacol. 2007 Feb 28;557(2-3):221-9.
• [473] D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
• [474] Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
• [475] COX-2 and PPAR-gama confer cannabidiol-induced apoptosis of human lung cancer cells. Mol Cancer Ther. 2013 Jan;12(1):69-82.
• [476] Protective effects of myricitrin against osteoporosis via reducing reactive oxygen species and bone-resorbing cytokines. Toxicol Appl Pharmacol. 2014 Nov 1;280(3):550-60.
• [477] The effect of quercetin and kaempferol aglycones and glucuronides on peroxisome proliferator-activated receptor-gamma (PPAR-). Food Funct. 2015 Apr;6(4):1098-107. doi: 10.1039/c5fo00076a.
• [478] Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3951-6. doi: 10.1073/pnas.96.7.3951.
• [479] Glucosamine sulfate reduces prostaglandin E(2) production in osteoarthritic chondrocytes through inhibition of microsomal PGE synthase-1. J Rheumatol. 2012 Mar;39(3):635-44. doi: 10.3899/jrheum.110621. Epub 2011 Nov 15.
• [480] Isoniazid suppresses antioxidant response element activities and impairs adipogenesis in mouse and human preadipocytes. Toxicol Appl Pharmacol. 2013 Dec 15;273(3):435-41. doi: 10.1016/j.taap.2013.10.005. Epub 2013 Oct 12.
• [481] Regulatory role of KEAP1 and NRF2 in PPAR expression and chemoresistance in human non-small-cell lung carcinoma cells. Free Radic Biol Med. 2012 Aug 15;53(4):758-68. doi: 10.1016/j.freeradbiomed.2012.05.041. Epub 2012 Jun 7.
• [482] Aspirin inhibits MMP-9 mRNA expression and release via the PPARalpha/gamma and COX-2/mPGES-1-mediated pathways in macrophages derived from THP-1 cells. Biomed Pharmacother. 2010 Feb;64(2):118-23. doi: 10.1016/j.biopha.2009.04.033. Epub 2009 Oct 17.
• [483] Mitochondrial proliferation, DNA depletion and adipocyte differentiation in subcutaneous adipose tissue of HIV-positive HAART recipients. Antivir Ther. 2003 Aug;8(4):323-31.
• [484] Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
• [485] Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
• [486] Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
• [487] BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
• [488] Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
• [489] Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
• [490] Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
• [491] Resveratrol compounds inhibit human holocarboxylase synthetase and cause a lean phenotype in Drosophila melanogaster. J Nutr Biochem. 2015 Nov;26(11):1379-84. doi: 10.1016/j.jnutbio.2015.07.004. Epub 2015 Jul 26.
• [492] Chromium(VI) causes down regulation of biotinidase in human bronchial epithelial cells by modifications of histone acetylation. Toxicol Lett. 2011 Aug 28;205(2):140-5. doi: 10.1016/j.toxlet.2011.05.1032. Epub 2011 May 27.
• [493] Defenses against oxidation in human erythrocytes: role of glutathione reductase in the activation of glucose decarboxylation by hemolytic drugs. J Lab Clin Med. 1991 Apr;117(4):325-31.
• [494] Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
• [495] Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
• [496] Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.
• [497] Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
• [498] Involvement of Asp-Glu-Val-Asp-directed, caspase-mediated mitogen-activated protein kinase kinase 1 Cleavage, c-Jun N-terminal kinase activation, and subsequent Bcl-2 phosphorylation for paclitaxel-induced apoptosis in HL-60 cells. Mol Pharmacol. 2001 Feb;59(2):254-62. doi: 10.1124/mol.59.2.254.
• [499] Arsenic and the epigenome: interindividual differences in arsenic metabolism related to distinct patterns of DNA methylation. J Biochem Mol Toxicol. 2013 Feb;27(2):106-15. doi: 10.1002/jbt.21462. Epub 2013 Jan 11.
• [500] Anticancer effects of cantharidin in A431 human skin cancer (Epidermoid carcinoma) cells in vitro and in vivo. Environ Toxicol. 2017 Mar;32(3):723-738. doi: 10.1002/tox.22273. Epub 2016 Apr 25.
• [501] Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor. Drug Metab Dispos. 2005 Jul;33(7):924-9.
• [502] Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways. Pharm Res. 2009 Apr;26(4):872-82.
• [503] Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
• [504] Fetal bovine serum and human constitutive androstane receptor: evidence for activation of the SV23 splice variant by artemisinin, artemether, and arteether in a serum-free cell culture system. Toxicol Appl Pharmacol. 2014 Jun 1;277(2):221-30. doi: 10.1016/j.taap.2014.03.023. Epub 2014 Apr 12.
• [505] Constitutive androstane/active receptor is a target of retinoic acid receptor in humans. Biochem Pharmacol. 2010 Jul 1;80(1):129-35. doi: 10.1016/j.bcp.2010.02.023. Epub 2010 Mar 6.
• [506] Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
• [507] Expression and inducibility of cytochrome P450s (CYP1A1, 2B6, 2E1, 3A4) in human cord blood CD34(+) stem cell-derived differentiating neuronal cells. Toxicol Sci. 2012 Oct;129(2):392-410.
• [508] Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay. Toxicol In Vitro. 2018 Feb;46:335-349. doi: 10.1016/j.tiv.2017.09.014. Epub 2017 Sep 18.
• [509] Teriflunomide is an indirect human constitutive androstane receptor (CAR) activator interacting with epidermal growth factor (EGF) signaling. Front Pharmacol. 2018 Oct 11;9:993.
• [510] Quercetin and Cisplatin combined treatment altered cell cycle and mitogen activated protein kinase expressions in malignant mesotelioma cells. BMC Complement Altern Med. 2016 Aug 11;16(1):281. doi: 10.1186/s12906-016-1267-x.
• [511] Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to arsenic trioxide. J Biol Chem. 2002 Nov 22;277(47):44988-95. doi: 10.1074/jbc.M207176200. Epub 2002 Sep 17.
• [512] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [513] Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
• [514] Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease. J Neurosci. 2016 Jun 8;36(23):6332-51. doi: 10.1523/JNEUROSCI.0426-16.2016.
• [515] P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation. Food Chem Toxicol. 2016 Feb;88:1-12. doi: 10.1016/j.fct.2015.12.004. Epub 2015 Dec 11.
• [516] Down-regulation of ALKBH2 increases cisplatin sensitivity in H1299 lung cancer cells. Acta Pharmacol Sin. 2011 Mar;32(3):393-8. doi: 10.1038/aps.2010.216. Epub 2011 Jan 31.
• [517] Susceptibility to drug-induced apoptosis correlates with differential modulation of Bad, Bcl-2 and Bcl-xL protein levels. Cell Death Differ. 2000 Jun;7(6):574-86. doi: 10.1038/sj.cdd.4400688.
• [518] Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells. Cancer Res. 2003 Feb 1;63(3):616-20.
• [519] Simvastatin induces activation of the serine-threonine protein kinase AKT and increases survival of isolated human pancreatic islets. Transplantation. 2002 Oct 27;74(8):1063-9. doi: 10.1097/00007890-200210270-00001.
• [520] Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Mol Cell Biochem. 2010 Nov;344(1-2):173-84. doi: 10.1007/s11010-010-0540-4. Epub 2010 Jul 25.
• [521] Down regulation of N-acetylglucosaminyltransferase V facilitates all-transretinoic acid to induce apoptosis of human hepatocarcinoma cells. Mol Cell Biochem. 2006 Mar;284(1-2):103-10. doi: 10.1007/s11010-005-9022-5. Epub 2006 Jan 13.