Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRFTJX)

• Drug Name: daidzein Drug Info
• Synonyms: Daidzein; 486-66-8; 4',7-Dihydroxyisoflavone; Daidzeol; 7,4'-Dihydroxyisoflavone; 7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one; 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-hydroxyphenyl)-; 7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 7-hydroxy-3-(4-hydroxyphenyl)chromen-4-one; 7-Hydroxy-3-(4-hydroxyphenyl)-4-benzopyrone; UNII-6287WC5J2L; CCRIS 7600; K 251b; 4,7-Dihydroxyisoflavone; EINECS 207-635-4; BRN 0231523; CHEMBL8145; 4',7-Dihydroxy-iso-flavone; d-(+)-alpha-methylbenzylamine; ,7-Dihydroxyisoflavone; 7,4'-dihydroxyisoflavone; DIADZEIN

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5281708
  ChEBI ID: CHEBI:28197
  CAS Number: CAS 486-66-8
  TTD Drug ID: DMRFTJX
  VARIDT Drug ID: DR00845
  INTEDE Drug ID: DR1986

Molecule-Related Drug Atlas

Drug(s) Targeting Short transient receptor potential channel 5 (TRPC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BI 1358894	DM740BS	Depression	6A70-6A7Z	Phase 2	[18]
GFB-887	DM2IJWG	Diabetic nephropathy	GB61.Z	Phase 2	[19]
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[20]
lysophosphatidylcholine	DMOGFVH	Discovery agent	N.A.	Investigative	[5]
KB-R7943	DMMD5W3	Discovery agent	N.A.	Investigative	[21]
BTP2	DMNM63G	Discovery agent	N.A.	Investigative	[5]
bromoenol lactone	DMKQ0CA	Discovery agent	N.A.	Investigative	[22]
ML204	DM15YL0	Discovery agent	N.A.	Investigative	[23]
(-)-englerin A	DMPQBWY	Discovery agent	N.A.	Investigative	[24]

Drug(s) Targeting Aldose reductase (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epalrestat	DM5OGK0	Diabetic neuropathy	8C0Z	Approved	[25]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[26]
Fidarestat	DMZL1I8	Diabetic complication	5A2Y	Phase 3	[27]
Ranirestat	DMD5QRS	Diabetic neuropathy	8C0Z	Phase 3	[28]
CONTIGOSIDE B	DMX9V8K	Thrombosis	DB61-GB90	Phase 2/3	[29]
BNV-222	DMYFQJL	Diabetic neuropathy	8C0Z	Phase 2/3	[28]
BNV-222	DMYFQJL	Diabetic neuropathy	8C0Z	Phase 2/3	[30]
LIDORESTAT	DMA0RI9	Diabetic complication	5A2Y	Phase 2	[31]
QR-333	DMKVIWM	Diabetic neuropathy	8C0Z	Phase 2	[32]
ADMVA	DM819CO	Diabetic complication	5A2Y	Phase 2	[28]

Drug(s) Targeting Estrogen-related receptor-beta (ESRRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
biochanin A	DM0HPWY	Discovery agent	N.A.	Investigative	[4]
DY131	DMFJ3VC	Discovery agent	N.A.	Investigative	[33]

Drug(s) Targeting Estrogen-related receptor-gamma (ESRRG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
biochanin A	DM0HPWY	Discovery agent	N.A.	Investigative	[4]
DY131	DMFJ3VC	Discovery agent	N.A.	Investigative	[34]
GSK4716	DMHUMP9	Discovery agent	N.A.	Investigative	[34]

Drug(s) Targeting Estrogen-related receptor-alpha (ESRRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rimexolone	DMTAREC	Arthritis	FA20	Approved	[35]
Pregnenolone	DM6VFO1	Schizophrenia	6A20	Phase 4	[36]
D-5519	DM9FAJM	Asthma	CA23	Phase 3	[37]
Dexamethasone palmitate	DMCMT4V	Choroidal neovascularization	9B76	Phase 1/2	[38]
RPR-106541	DMRGC5B	Asthma	CA23	Discontinued in Phase 2	[39]
Rofleponide	DM6OSPQ	Allergic rhinitis	CA08.0	Discontinued in Phase 2	[40]
AD-121	DMB8XJM	Rheumatoid arthritis	FA20	Discontinued in Phase 1/2	[35]
GW-250495	DMWJZAP	Asthma	CA23	Discontinued in Phase 1	[35]
PLD-177	DMPHUBO	Allergic rhinitis	CA08.0	Terminated	[35]
Steroid hormone conjugates	DMOJM08	Cachexia	MG20	Terminated	[41]

Drug(s) Targeting Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Conjugated Estrogens	DMLT0E1	Dyspareunia	GA12	Approved	[42]
Trilostane	DMQZ9GF	Cushing disease	5A70	Approved	[43]
ARZOXIFENE	DMOKCVI	Breast cancer	2C60-2C65	Approved	[44]
Estrogen	DMGY0UT	Menopause symptom	GA30.0	Approved	[45]
MF-101	DM8Z0I3	Hepatitis virus infection	1E50-1E51	Phase 3	[46]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[47]
AUS-131	DMUXO3Z	Hot flushes	GA30	Phase 2	[48]
ERB-041	DMCEPUA	Inflammatory bowel disease	DD72	Phase 2	[49]
Erteberel	DMU1XZD	Prostate hyperplasia	GA90	Phase 2	[50]
VG-101	DMAN21O	Menopause symptom	GA30.0	Phase 1/2	[51]

Drug(s) Targeting Estrogen receptor (ESR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[52]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[53]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[53]
Estradiol Valerate	DM8MC6O	Hormone replacement therapy	8E01	Approved	[43]
Estradiol Acetate	DM07U2A	Hormone replacement therapy	8E01	Approved	[43]
Estradiol Cypionate	DM27Z5T	Hormone replacement therapy	8E01	Approved	[43]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[54]
Raloxifene	DMDKF3M	Osteoporosis	FB83.0	Approved	[55]
Ospemifene	DMC4GEI	Dyspareunia	GA12	Approved	[56]
Toremifene	DMQYUWG	Breast cancer	2C60-2C65	Approved	[57]

Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[58]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[59]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[60]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[62]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[63]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[63]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[65]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[66]

Drug(s) Metabolized By Sulfotransferase 2A1 (SULT2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[7]
Abiraterone acetate	DMANBZI	Prostate cancer	2C82.0	Approved	[67]
Vonoprazan	DMO6315	Helicobacter infection	DA42-DA63	Approved	[68]
Pregnenolone	DM6VFO1	Schizophrenia	6A20	Phase 4	[69]
ASP-015K	DMZ1UOI	Psoriasis vulgaris	EA90	Phase 3	[70]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[7]
BCP-13498	DM2BO9W	N. A.	N. A.	Phase 2	[71]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[7]
Tetramethylbutylphenol	DMW9CH2	N. A.	N. A.	Investigative	[7]
N-nonylphenol	DMH3OUX	N. A.	N. A.	Investigative	[7]

Drug(s) Metabolized By Cytochrome P450 102D1 (cyp102)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[8]

Drug(s) Affected By Metallothionein-2 (MT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[77]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[80]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[81]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[82]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[83]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[84]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[85]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[86]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[87]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[88]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[89]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[90]

Drug(s) Affected By Tumor protein p53-inducible protein 11 (TP53I11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[14]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[99]

Drug(s) Affected By Beta-enolase (ENO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[100]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[105]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[106]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[108]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[109]

Drug(s) Affected By Insulin-like growth factor-binding protein 4 (IGFBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Selenium	DM25CGV	N. A.	N. A.	Approved	[112]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[100]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[116]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[117]

Drug(s) Affected By Nuclear receptor-interacting protein 1 (NRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[120]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[122]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[125]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[126]

Drug(s) Affected By Ribosomal protein S6 kinase alpha-3 (RPS6KA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[129]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[132]

Drug(s) Affected By Rho GDP-dissociation inhibitor 1 (ARHGDIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Selenium	DM25CGV	N. A.	N. A.	Approved	[112]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[136]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[137]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[102]

Drug(s) Affected By Solute carrier family 12 member 2 (SLC12A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[136]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Furosemide	DMMQ8ZG	Congestive heart failure	BD10	Approved	[141]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[136]

Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Selenium	DM25CGV	N. A.	N. A.	Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[145]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[114]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[146]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[143]

Drug(s) Affected By Protein kinase C delta type (PRKCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[78]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[147]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[148]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[149]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[150]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[116]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[152]

Drug(s) Affected By Tumor protein D53 (TPD52L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[114]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[129]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[129]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[81]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]

Drug(s) Affected By Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (PDZK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[114]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]
Mestranol	DMG3F94	Contraception	QA21	Approved	[143]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[156]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[157]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[157]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[157]

Drug(s) Affected By DNA endonuclease RBBP8 (RBBP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[143]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[129]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[158]
Mestranol	DMG3F94	Contraception	QA21	Approved	[143]

Drug(s) Affected By Choline O-acetyltransferase (CHAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[160]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[160]
Scopolamine	DMOM8AL	Addictive disorder	6C50-6C5Z	Approved	[161]
Methamphetamine	DMPM4SK	Anxiety		Approved	[162]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[163]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[164]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[166]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[167]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[169]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[171]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[172]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[174]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[175]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[177]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[178]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[169]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[179]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[180]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[181]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[164]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[182]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[171]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[172]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[184]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[164]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[185]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[100]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[186]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[187]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[188]
Fructose	DM43AN2	Vomiting	MD90	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[190]

Drug(s) Affected By Prostate-specific antigen (KLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[191]
Selenium	DM25CGV	N. A.	N. A.	Approved	[192]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[193]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[194]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[195]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[196]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[197]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[129]

Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[199]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[200]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[201]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[205]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[129]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[129]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[81]

Drug(s) Affected By NADP-dependent malic enzyme (ME1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Selenium	DM25CGV	N. A.	N. A.	Approved	[112]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[209]

Drug(s) Affected By Dual specificity protein phosphatase 4 (DUSP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[114]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[158]

Drug(s) Affected By Homeobox protein Nkx-3.1 (NKX3-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[193]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[210]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[211]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[212]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[213]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[214]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[215]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[216]

Drug(s) Affected By STE20/SPS1-related proline-alanine-rich protein kinase (STK39)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[217]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[108]

Drug(s) Affected By Catechol O-methyltransferase (COMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[218]
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[218]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[218]
Modafinil	DMYILBE	Malignant glioma	2A00.0	Approved	[219]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[218]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[221]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[223]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[224]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[225]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[225]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[226]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[227]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[228]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[229]

Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[231]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[232]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[233]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[234]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[235]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[236]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[225]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[237]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[238]

Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[239]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[225]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[224]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[236]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[240]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[225]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[241]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[224]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[225]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[242]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[82]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[243]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[244]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[245]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[77]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[246]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[247]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[248]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[249]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[81]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[250]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[251]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[252]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[253]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[254]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[255]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[256]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[257]

Drug(s) Affected By Lysosome-associated membrane glycoprotein 3 (LAMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[258]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[259]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[260]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[261]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[261]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]

Drug(s) Affected By Serine/threonine-protein kinase Sgk1 (SGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[263]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[264]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[265]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[266]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[267]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[116]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[182]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[268]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[269]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[271]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[273]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]

Drug(s) Affected By Receptor-binding cancer antigen expressed on SiSo cells (EBAG9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[215]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[15]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[15]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[274]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[275]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[276]

Drug(s) Affected By Cytochrome c oxidase subunit 7A-related protein, mitochondrial (COX7A2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[122]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[108]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[277]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[15]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[278]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[15]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[279]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[280]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 11 (TNFSF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[268]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[281]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[282]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[283]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[284]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[285]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]

Drug(s) Affected By Serine protease 23 (PRSS23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[143]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[116]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[129]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[287]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[288]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[289]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[127]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[289]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[290]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[291]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[292]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[293]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[127]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[294]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Selenium	DM25CGV	N. A.	N. A.	Approved	[295]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[296]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[297]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[298]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[299]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[300]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[302]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[303]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[304]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[305]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[306]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[303]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[308]

Drug(s) Affected By Trefoil factor 1 (TFF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[309]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[310]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[311]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[312]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[313]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[310]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[314]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[315]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[316]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[317]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[299]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[318]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[319]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[320]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[321]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[322]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[323]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[324]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[325]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[326]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[327]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[90]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[328]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[329]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[330]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[331]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[332]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[326]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[333]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[334]
Fructose	DM43AN2	Vomiting	MD90	Approved	[164]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[335]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[336]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[127]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[337]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[339]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[340]

Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[341]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[342]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[343]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[344]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[345]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[346]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[316]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[347]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[348]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]

Drug(s) Affected By Thyroid peroxidase (TPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[159]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[349]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[350]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[351]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[352]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[353]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[151]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[351]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[142]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[353]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[354]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[356]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[357]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[358]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[357]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[359]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[360]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[361]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[362]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[363]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[364]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[90]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[336]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[329]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[365]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[251]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[366]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[365]

Drug(s) Affected By Myb-related protein A (MYBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[367]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[368]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[258]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[264]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[369]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[370]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[371]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[372]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[164]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[373]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[374]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[171]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[375]

Drug(s) Affected By Alkaline phosphatase, germ cell type (ALPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[376]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[377]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[10]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[378]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[376]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[379]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[380]
Lithium chloride	DMHYLQ2	Discovery agent	N.A.	Investigative	[381]
Hydroxyestradiol	DMJXQME	N. A.	N. A.	Investigative	[10]

Drug(s) Affected By Thyroid hormone receptor alpha (THRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[382]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[383]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[108]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[140]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[384]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[278]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[155]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[385]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[386]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[203]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[387]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[388]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[389]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[390]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[389]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[145]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[287]

Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[391]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[392]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[393]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[393]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[299]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[394]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[395]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[396]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[393]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[397]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[398]
Selenium	DM25CGV	N. A.	N. A.	Approved	[295]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[399]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[400]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[401]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[402]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[403]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]

Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[390]
Selenium	DM25CGV	N. A.	N. A.	Approved	[295]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[201]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[404]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[405]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[400]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[406]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[407]

Drug(s) Affected By Creatine kinase B-type (CKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Selenium	DM25CGV	N. A.	N. A.	Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[408]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[408]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[409]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[410]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[411]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[404]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[412]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[413]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[406]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[414]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[415]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[416]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[375]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[417]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[418]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[419]
Selenium	DM25CGV	N. A.	N. A.	Approved	[112]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[296]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[420]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[421]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[411]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[422]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Selenium	DM25CGV	N. A.	N. A.	Approved	[295]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[358]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[424]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[425]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[401]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[403]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[427]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[428]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[429]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[430]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[431]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[432]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[433]

Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[434]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[435]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[400]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[436]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[437]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[287]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[438]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[288]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[337]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[439]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[418]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[440]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[441]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[358]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[265]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[442]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[443]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[444]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[320]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[445]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[446]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[447]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[448]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[449]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[450]

Drug(s) Affected By Stromal cell-derived factor 1 (CXCL12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[451]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[299]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[452]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[114]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[143]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[453]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[142]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[454]

Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[299]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[101]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[455]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[456]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[457]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[80]

Drug(s) Affected By Focal adhesion kinase 1 (PTK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[458]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[406]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[459]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[460]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[461]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[462]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[463]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[323]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[464]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[356]
Selenium	DM25CGV	N. A.	N. A.	Approved	[112]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[465]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[400]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[466]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[467]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[468]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[77]

Drug(s) Affected By Nuclear receptor coactivator 1 (NCOA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[469]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[470]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[471]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[278]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[155]

Drug(s) Affected By Protein GREB1 (GREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[264]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[313]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[151]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[264]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[310]
Mestranol	DMG3F94	Contraception	QA21	Approved	[264]

Drug(s) Affected By Organic anion transporter 3 (SLC22A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[472]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[473]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[474]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[475]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[476]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[476]
Cefdinir	DMJ7A0H	Bacterial infection	1A00-1C4Z	Approved	[477]
Cefaclor	DMJXDGC	Bacterial infection	1A00-1C4Z	Approved	[477]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[478]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[479]

Drug(s) Affected By Solute carrier family 22 member 11 (SLC22A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[480]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[480]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[273]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[480]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[480]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[481]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[480]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[482]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[480]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[483]

Drug(s) Affected By Solute carrier organic anion transporter family member 2B1 (SLCO2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[145]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[484]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[485]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[315]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[486]

Drug(s) Affected By Sodium-dependent organic anion transporter (SLC10A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[487]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]
[3H]estrone-3-sulphate	DMGPF0N	Discovery agent	N.A.	Investigative	[488]

Drug(s) Affected By Hepatic sodium/bile acid cotransporter (SLC10A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[207]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[489]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[273]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[490]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[491]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[492]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[493]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[130]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[494]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aldose reductase (AKR1B1)	TTFBNVI	ALDR_HUMAN	Inhibitor	[2]
Estrogen receptor (ESR)	TTZAYWL	ESR1_HUMAN	Inhibitor	[3]
Estrogen receptor beta (ESR2)	TTOM3J0	ESR2_HUMAN	Inhibitor	[3]
Estrogen-related receptor-alpha (ESRRA)	TTPNQAC	ERR1_HUMAN	Agonist	[4]
Estrogen-related receptor-beta (ESRRB)	TTKF0XS	ERR2_HUMAN	Agonist	[4]
Estrogen-related receptor-gamma (ESRRG)	TT9ZRHB	ERR3_HUMAN	Agonist	[4]
Short transient receptor potential channel 5 (TRPC5)	TT32NQ1	TRPC5_HUMAN	Activator	[5]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[6]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Sulfotransferase 2A1 (SULT2A1)	DE0P6LK	ST2A1_HUMAN	Substrate	[7]
Cytochrome P450 102D1 (cyp102)	DEUWAV0	CPXB_BACMB	Substrate	[8] , [9]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Alkaline phosphatase, germ cell type (ALPG)	OTCIM29R	PPBN_HUMAN	Gene/Protein Processing	[10]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[11]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Gene/Protein Processing	[12]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Protein Interaction/Cellular Processes	[13]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[11]
Beta-enolase (ENO3)	OT3HYKYI	ENOB_HUMAN	Gene/Protein Processing	[14]
Breast cancer type 1 susceptibility protein (BRCA1)	OT5BN6VH	BRCA1_HUMAN	Gene/Protein Processing	[15]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)	OTI862QH	CPT1A_HUMAN	Gene/Protein Processing	[16]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[11]
Catechol O-methyltransferase (COMT)	OTPWKTQG	COMT_HUMAN	Gene/Protein Processing	[17]

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