Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3PD2C)

• Drug Name: Fluoxetine Drug Info
• Synonyms: Eufor; Floxetine; Fluoxetin; Fluoxetina; Fluoxetinum; Fluval; Fontex; Portal; Pulvules; Reconcile; Reneuron; Fluoxetina [Spanish]; Fluoxetine Hcl; Prozac Weekly; Animex-On; Fluoxetina [INN-Spanish]; Fluoxetine (Prozac); Fluoxetine (TN); Fluoxetinum [INN-Latin]; Lilly-110140; Prozac (TN); Fluoxetine (USAN/INN); Fluoxetine [USAN:INN:BAN]; N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine; Methyl({3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl})amine; N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine; Dl-3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine; Methyl-[3-phenyl-3-(4-trifluoromethyl-phenoxy)-propyl]-amine; N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine; N-methyl-3-phenyl-3-{[4-(trifluoromethyl)phenyl]oxy}propan-1-amine; (+-)-N-Methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-p-tolyl)oxy)propylamine; (+-)-N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine;(+/-)-Fluoxetine; (+/-)-N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine; (+/-)-N-Methyl-3-p-(p-trifluoromethylphenoxy)-3-phenylpropylamine; (+/-)-N-Methyl-3-phenyl-3-[(alpha,alpha,alpha-trifluoro-p-tolyl)oxy]propylamine; (+/-)-N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine]; (+/-)-N-Methyl-gamma-[4-(trifluoromethyl)phenoxy]benzenepropanamine; 3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine

Indication

Disease Entry	ICD 11	Status	REF
Bipolar depression		Approved	[1]
Bulimia nervosa	6B81	Approved	[1]
Depression	6A70-6A7Z	Approved	[2]
Intracerebral hemorrhage		Approved	[1]
Major depressive disorder	6A70.3	Approved	[1]
Obsessive compulsive disorder	6B20	Approved	[1]
Panic disorder	6B01	Approved	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 3	[3]

• Therapeutic Class: Antidepressants
• Cross-matching ID:
  PubChem CID: 3386
  ChEBI ID: CHEBI:86990
  CAS Number: CAS 54910-89-3
  TTD Drug ID: DM3PD2C
  VARIDT Drug ID: DR00459
  INTEDE Drug ID: DR0720
  ACDINA Drug ID: D00283

Molecule-Related Drug Atlas

Drug(s) Targeting Serotonin transporter (SERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[18]
Vortioxetine	DM6F1PU	Major depressive disorder	6A70.3	Approved	[19]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[20]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[21]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[22]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[4]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[4]
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[4]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[4]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[23]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[24]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[25]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[26]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[25]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[27]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[25]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[28]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[29]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[30]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[31]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[32]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[34]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[36]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[37]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[31]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[38]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[39]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[40]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[41]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[36]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[45]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[46]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[47]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[49]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[50]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[34]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[51]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[52]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[53]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[54]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[55]

Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[57]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[58]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[61]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[62]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[63]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[64]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[59]

Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[68]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[69]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[45]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[70]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[71]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[72]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[73]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[74]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[75]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[70]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[77]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[70]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[78]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[79]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]

Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[82]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[70]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[83]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[85]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[86]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[87]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[88]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[89]

Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[90]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[74]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[91]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[92]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[70]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[93]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[95]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[96]

Drug(s) Affected By Sodium-dependent serotonin transporter (SLC6A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[97]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[99]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[100]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[103]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Mepyramine	DMB4SFH	Allergic rhinitis	CA08.0	Approved	[105]

Drug(s) Affected By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[106]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[107]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[106]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[107]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[108]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[106]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[106]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[106]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[109]
Dabrafenib	DMX6OE3	Melanoma	2C30	Approved	[110]

Drug(s) Affected By Nuclear protein 1 (NUPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[16]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[112]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[113]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[16]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[16]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[112]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[112]

Drug(s) Affected By Alpha-1-antichymotrypsin (SERPINA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[16]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[113]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[16]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[16]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[117]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[117]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[16]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[118]

Drug(s) Affected By Serine protease hepsin (HPN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[16]
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[16]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[16]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[112]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]

Drug(s) Affected By Fatty acid-binding protein, liver (FABP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[16]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[113]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[16]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[124]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[112]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[16]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[125]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[16]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[16]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[128]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[112]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[128]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[131]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[132]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[16]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[113]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[133]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[16]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[135]

Drug(s) Affected By Lanosterol synthase (LSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[16]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[136]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[16]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[16]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[112]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[16]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[16]

Drug(s) Affected By Inhibin beta E chain (INHBE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[16]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[113]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[16]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[16]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[112]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[16]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[139]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[112]

Drug(s) Affected By AP-1 complex subunit sigma-1A (AP1S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[16]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[112]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[143]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[113]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[112]

Drug(s) Affected By Transgelin (TAGLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[16]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[113]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[16]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[113]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[147]

Drug(s) Affected By Acid ceramidase (ASAH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[16]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[148]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[16]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[112]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[16]

Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[151]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[16]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[136]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[16]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[112]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[155]

Drug(s) Affected By Fibronectin type III domain-containing protein 4 (FNDC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[16]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[16]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[16]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[112]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[16]
Haloperidol	DM96SE0	Delirium		Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[16]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[16]

Drug(s) Affected By Protein DEPP1 (DEPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[16]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[112]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[16]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[16]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[157]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[112]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[112]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[16]

Drug(s) Affected By Lysophospholipase D GDPD3 (GDPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[16]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[113]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[16]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[112]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[16]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[158]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[159]
Haloperidol	DM96SE0	Delirium		Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]

Drug(s) Affected By 5-hydroxytryptamine receptor 2C (HTR2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[15]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[15]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[161]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Clomipramine	DMINRKW	Depression	6A70-6A7Z	Approved	[15]

Drug(s) Affected By Protein EVI2A (EVI2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[120]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[165]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[166]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[167]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[168]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[169]

Drug(s) Affected By Inactive phospholipase C-like protein 1 (PLCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[170]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[171]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[164]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[121]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[173]

Drug(s) Affected By Cyclin-G2 (CCNG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[139]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[162]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[176]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[164]

Drug(s) Affected By Kelch-like protein 24 (KLHL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[157]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[178]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[179]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[180]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[181]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[132]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[182]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[183]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[182]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[128]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[184]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]

Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[185]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[186]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[187]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[152]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[187]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[188]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[189]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[190]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[136]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[191]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[191]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[116]
Fructose	DM43AN2	Vomiting	MD90	Approved	[192]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[193]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[191]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[194]

Drug(s) Affected By Ras-related protein Rab-7L1 (RAB29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[180]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[165]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[196]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[197]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[198]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[199]

Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[201]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[203]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[159]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[159]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 4 (ACSL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[204]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[205]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[143]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[197]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[198]

Drug(s) Affected By Lathosterol oxidase (SC5D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[202]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[208]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Haloperidol	DM96SE0	Delirium		Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[208]

Drug(s) Affected By Membrane protein BRI3 (BRI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[165]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[209]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[197]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[210]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[211]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[212]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[215]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[216]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[217]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[218]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[219]

Drug(s) Affected By Fatty acid CoA ligase Acsl3 (ACSL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[202]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[159]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[221]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[143]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[222]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[223]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[224]

Drug(s) Affected By Acyl-CoA 6-desaturase (FADS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[201]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[143]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[226]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[227]
Bortezomib	DMNO38U	Leukemia		Approved	[228]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[229]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[231]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[232]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[231]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[233]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[235]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[237]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[238]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[232]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[233]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[239]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[240]
Selenium	DM25CGV	N. A.	N. A.	Approved	[241]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[242]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[243]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[244]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]

Drug(s) Affected By Prolactin (PRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[245]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[246]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[247]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[248]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[249]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[250]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[251]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[252]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[253]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[254]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[255]
Fructose	DM43AN2	Vomiting	MD90	Approved	[256]
Ketoprofen	DMRKXPT	Bursitis		Approved	[256]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[257]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[258]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[259]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[260]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[261]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[262]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[263]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[264]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[256]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[265]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[266]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[267]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[268]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[269]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[270]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[271]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[272]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[273]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[275]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[276]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[277]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]
Fructose	DM43AN2	Vomiting	MD90	Approved	[256]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[279]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[280]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[232]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[281]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[183]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[282]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[283]

Drug(s) Affected By Fatty acid-binding protein, heart (FABP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[284]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[139]
Haloperidol	DM96SE0	Delirium		Approved	[285]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[178]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[176]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[285]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[286]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[287]
Methamphetamine	DMPM4SK	Anxiety		Approved	[288]

Drug(s) Affected By Fructose-bisphosphate aldolase C (ALDOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[157]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[289]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[290]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[143]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[291]

Drug(s) Affected By Sphingomyelin phosphodiesterase (SMPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[292]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[193]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[293]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[143]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[165]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]

Drug(s) Affected By HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
Cinoxacin	DM4EWNS	Urinary tract infection	GC08	Approved	[294]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[294]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Cephalexin	DMD5JU8	Acute otitis media	AB00	Approved	[294]
Aztreonam	DMDNJHG	Bacterial infection	1A00-1C4Z	Approved	[294]

Drug(s) Affected By Transcobalamin-2 (TCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[295]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[197]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[296]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[168]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[297]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[298]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[299]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[300]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[301]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[233]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[265]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[302]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[303]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[304]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[305]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[306]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]

Drug(s) Affected By Potassium voltage-gated channel subfamily A member 3 (KCNA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[307]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[307]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Econazole	DMFSWGH	Cutaneous candidiasis	1F23.14	Approved	[307]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[308]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[309]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[310]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[168]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[311]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[312]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[313]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[314]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[315]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[316]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[317]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[318]
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[242]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[319]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[320]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[302]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[321]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[303]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[322]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[323]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[324]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[325]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[326]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[327]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[328]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[258]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[329]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[331]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[332]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[333]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[334]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[335]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[327]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[336]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[337]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[338]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[326]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[256]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[339]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[258]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[329]

Drug(s) Affected By Glucose-6-phosphatase catalytic subunit 1 (G6PC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[340]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[341]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[342]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[138]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[138]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[343]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[344]

Drug(s) Affected By Squalene synthase (FDFT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[345]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[157]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[202]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[220]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[346]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[205]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[143]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[347]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[348]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[281]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[349]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[317]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[265]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[350]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[351]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[321]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[352]

Drug(s) Affected By Melanocyte protein PMEL (PMEL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[202]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[353]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[354]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[355]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[356]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[357]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[358]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[198]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[359]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[293]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[360]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[361]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[271]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[362]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[363]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[364]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[365]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[366]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[367]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[368]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[316]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[351]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[369]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[370]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[371]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[372]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[373]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[374]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[375]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[376]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[232]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[377]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[378]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[379]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[379]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[380]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[381]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[382]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[383]

Drug(s) Affected By 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[384]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[157]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[202]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[165]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[356]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[309]

Drug(s) Affected By Cyclin-dependent kinases regulatory subunit 1 (CKS1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[385]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[143]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[386]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[387]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[388]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[191]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[389]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[193]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[201]

Drug(s) Affected By Mevalonate kinase (MVK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[136]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[228]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[287]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]

Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[390]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[391]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[392]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[393]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[393]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[394]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[395]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[396]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[397]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[393]

Drug(s) Affected By Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[389]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[164]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[202]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[143]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[285]

Drug(s) Affected By Beclin-1 (BECN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[398]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[399]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[380]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[400]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[401]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[402]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[403]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[404]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[405]

Drug(s) Affected By Squalene monooxygenase (SQLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[406]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[407]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[162]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[354]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[408]

Drug(s) Affected By Phosphatidate phosphatase LPIN1 (LPIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[193]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[409]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[228]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[165]

Drug(s) Affected By 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[202]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[410]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[143]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[226]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[165]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[229]

Drug(s) Affected By Mitochondrial fission regulator 1 (MTFR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[157]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[354]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[355]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[355]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[197]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[119]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[168]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[411]

Drug(s) Affected By Delta(24)-sterol reductase (DHCR24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[412]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[202]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[413]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[143]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[285]

Drug(s) Affected By Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[414]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[143]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[226]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[287]

Drug(s) Affected By Methylsterol monooxygenase 1 (MSMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[159]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[415]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[416]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[417]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[417]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[418]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[419]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[420]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[292]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[421]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[422]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[265]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[423]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[424]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[425]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[426]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[427]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[428]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[429]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[430]

Drug(s) Affected By LON peptidase N-terminal domain and RING finger protein 1 (LONRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[181]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[229]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[431]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[432]

Drug(s) Affected By Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (PIP4P1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[143]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[165]
Bortezomib	DMNO38U	Leukemia		Approved	[228]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[433]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[197]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[411]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[434]

Drug(s) Affected By Osteopetrosis-associated transmembrane protein 1 (OSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[157]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[435]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[436]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[165]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[433]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[437]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[438]

Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 11 (GALNT11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[439]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[440]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[226]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[356]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[433]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[197]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[441]

Drug(s) Affected By RCC1 and BTB domain-containing protein 1 (RCBTB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[309]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[433]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[199]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[168]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[442]

Drug(s) Affected By Folliculin (FLCN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[171]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[443]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[444]
Bortezomib	DMNO38U	Leukemia		Approved	[228]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[98]

Drug(s) Affected By Folliculin-interacting protein 1 (FNIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[445]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[446]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[355]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[355]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[434]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[434]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[170]

Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[447]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[448]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[449]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[450]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[451]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[452]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[453]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[454]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[455]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[196]

Drug(s) Affected By StAR-related lipid transfer protein 4 (STARD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[309]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[456]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[197]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[457]

Drug(s) Affected By Sodium-coupled neutral amino acid symporter 2 (SLC38A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[135]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[375]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[458]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[143]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[375]

Drug(s) Affected By Ethanolamine-phosphate cytidylyltransferase (PCYT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[407]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[287]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[459]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[309]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[197]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[198]

Drug(s) Affected By Sialidase-1 (NEU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[460]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[229]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[461]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[309]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[433]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[197]

Drug(s) Affected By 17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[462]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[463]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[181]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[165]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[355]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[355]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[464]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[168]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[411]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[464]

Drug(s) Affected By Ethanolaminephosphotransferase 1 (SELENOI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[309]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[358]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[411]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[442]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[180]

Drug(s) Affected By Pantothenate kinase 3 (PANK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[193]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[202]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[465]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[466]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]

Drug(s) Affected By Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium Acetate Anhydrous	DMH21E0	Hyponatraemia	5C72	Approved	[467]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[407]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[143]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[138]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[226]

Drug(s) Affected By 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[468]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[356]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[196]

Drug(s) Affected By Maspardin (SPG21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[197]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[168]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[411]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[298]

Drug(s) Affected By 7-dehydrocholesterol reductase (DHCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[469]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[157]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[202]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[375]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[410]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[120]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[220]

Drug(s) Affected By Potassium voltage-gated channel subfamily D member 3 (KCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[470]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[196]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[197]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[198]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[471]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[472]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[170]

Drug(s) Affected By Ergosterol biosynthetic protein 28 homolog (ERG28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[202]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[204]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[171]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]

Drug(s) Affected By 5-hydroxytryptamine receptor 1A (HTR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[473]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[473]
Methamphetamine	DMPM4SK	Anxiety		Approved	[474]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[475]
Perospirone	DMVHJLX	Psychotic disorder	6A20-6A25	Approved	[475]
Etoperidone	DMR7U8F	N. A.	N. A.	Phase 4	[473]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[476]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[168]
DU 125530	DM63UA9	Mood disorder	6A60-6E23	Discontinued in Phase 2	[477]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[476]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[478]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[479]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[480]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[481]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[256]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[482]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[483]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[258]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[314]

Drug(s) Affected By Tryptophan 5-hydroxylase 2 (TPH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[484]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[168]

Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[485]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[486]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[487]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[488]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[195]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[178]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Modulator	[4]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[5]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[6]
Cytochrome P450 2E1 (CYP2E1)	DEVDYN7	CP2E1_HUMAN	Substrate	[7]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[8]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[9]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[10]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[11]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[8]
Cytochrome P450 2B6 (CYP2B6)	DEPKLMQ	CP2B6_HUMAN	Substrate	[12]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3)	OTR4990X	PLPL3_HUMAN	Gene/Protein Processing	[13]
17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14)	OT0ETO72	DHB14_HUMAN	Gene/Protein Processing	[13]
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP)	OTSMGKXQ	EBP_HUMAN	Gene/Protein Processing	[13]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[13]
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7)	OTV7VOV3	DHB7_HUMAN	Gene/Protein Processing	[13]
5-hydroxytryptamine receptor 1A (HTR1A)	OT38K9MK	5HT1A_HUMAN	Drug Response	[14]
5-hydroxytryptamine receptor 2C (HTR2C)	OT6H8DE0	5HT2C_HUMAN	Protein Interaction/Cellular Processes	[15]
7-dehydrocholesterol reductase (DHCR7)	OTLILBUI	DHCR7_HUMAN	Gene/Protein Processing	[13]
Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2)	OTB1FZJU	ACSA_HUMAN	Gene/Protein Processing	[13]
Acid ceramidase (ASAH1)	OT1DNGXL	ASAH1_HUMAN	Gene/Protein Processing	[16]

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