Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3PD2C)

Drug Name
Fluoxetine Drug Info
Synonyms
Eufor; Floxetine; Fluoxetin; Fluoxetina; Fluoxetinum; Fluval; Fontex; Portal; Pulvules; Reconcile; Reneuron; Fluoxetina [Spanish]; Fluoxetine Hcl; Prozac Weekly; Animex-On; Fluoxetina [INN-Spanish]; Fluoxetine (Prozac); Fluoxetine (TN); Fluoxetinum [INN-Latin]; Lilly-110140; Prozac (TN); Fluoxetine (USAN/INN); Fluoxetine [USAN:INN:BAN]; N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine; Methyl({3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl})amine; N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine; Dl-3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine; Methyl-[3-phenyl-3-(4-trifluoromethyl-phenoxy)-propyl]-amine; N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine; N-methyl-3-phenyl-3-{[4-(trifluoromethyl)phenyl]oxy}propan-1-amine; (+-)-N-Methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-p-tolyl)oxy)propylamine; (+-)-N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine;(+/-)-Fluoxetine; (+/-)-N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine; (+/-)-N-Methyl-3-p-(p-trifluoromethylphenoxy)-3-phenylpropylamine; (+/-)-N-Methyl-3-phenyl-3-[(alpha,alpha,alpha-trifluoro-p-tolyl)oxy]propylamine; (+/-)-N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine]; (+/-)-N-Methyl-gamma-[4-(trifluoromethyl)phenoxy]benzenepropanamine; 3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine
Indication
Disease Entry ICD 11 Status REF
Depression 6A70-6A7Z Approved [1] , [2]
Therapeutic Class
Antidepressants
Cross-matching ID
PubChem CID
3386
ChEBI ID
CHEBI:86990
CAS Number
CAS 54910-89-3
TTD Drug ID
DM3PD2C
VARIDT Drug ID
DR00459
INTEDE Drug ID
DR0720
ACDINA Drug ID
D00283

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Solid tumour/cancer 2A00-2F9Z Approved [12]
Progesterone DMUY35B Premature labour JB00 Approved [13]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [14]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [15]
Acetaminophen DMUIE76 Pain MG30-MG3Z Approved [16]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [17]
Etoposide DMNH3PG Solid tumour/cancer 2A00-2F9Z Approved [18]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [19]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [13]
Verapamil DMA7PEW Hypertension BA00-BA04 Approved [20]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Solid tumour/cancer 2A00-2F9Z Approved [21]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [22]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [23]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [24]
Acetaminophen DMUIE76 Pain MG30-MG3Z Approved [25]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [26]
Etoposide DMNH3PG Solid tumour/cancer 2A00-2F9Z Approved [18]
Oxaliplatin DMQNWRD Colorectal cancer 2B91.Z Approved [27]
Verapamil DMA7PEW Hypertension BA00-BA04 Approved [28]
Diclofenac DMPIHLS Osteoarthritis FA00-FA05 Approved [29]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Solid tumour/cancer 2A00-2F9Z Approved [30]
Progesterone DMUY35B Premature labour JB00 Approved [31]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [32]
Acetaminophen DMUIE76 Pain MG30-MG3Z Approved [16]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [20]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [33]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [34]
Dopamine DMPGUCF Parkinson disease 8A00.0 Approved [35]
Nicotine DMWX5CO Nicotine dependence 6C4A.2 Approved [36]
Propranolol DM79NTF Migraine 8A80 Approved [37]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Solid tumour/cancer 2A00-2F9Z Approved [38]
Progesterone DMUY35B Premature labour JB00 Approved [39]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [40]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [41]
Acetaminophen DMUIE76 Pain MG30-MG3Z Approved [42]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [43]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [44]
Etoposide DMNH3PG Solid tumour/cancer 2A00-2F9Z Approved [45]
Verapamil DMA7PEW Hypertension BA00-BA04 Approved [46]
Sorafenib DMS8IFC Hepatocellular carcinoma 2C12.02 Approved [41]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic acid DMEMBJC Folate-deficiency anemia 3A02.Y Approved [47]
Cisplatin DMRHGI9 Solid tumour/cancer 2A00-2F9Z Approved [48]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [49]
Acetaminophen DMUIE76 Pain MG30-MG3Z Approved [50]
Etoposide DMNH3PG Solid tumour/cancer 2A00-2F9Z Approved [51]
Oxaliplatin DMQNWRD Colorectal cancer 2B91.Z Approved [27]
Verapamil DMA7PEW Hypertension BA00-BA04 Approved [52]
Estrone DM5T6US Menopausal and postmenopausal disorder GA30 Approved [53]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [54]
Ethanol DMDRQZU Chronic pain MG30 Approved [55]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Premature labour JB00 Approved [56]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [57]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [58]
Acetaminophen DMUIE76 Pain MG30-MG3Z Approved [52]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [59]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [52]
Verapamil DMA7PEW Hypertension BA00-BA04 Approved [60]
Diclofenac DMPIHLS Osteoarthritis FA00-FA05 Approved [61]
Estrone DM5T6US Menopausal and postmenopausal disorder GA30 Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [64]
Verapamil DMA7PEW Hypertension BA00-BA04 Approved [52]
Diclofenac DMPIHLS Osteoarthritis FA00-FA05 Approved [65]
Estrone DM5T6US Menopausal and postmenopausal disorder GA30 Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [66]
Irinotecan DMP6SC2 Colorectal cancer 2B91.Z Approved [67]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [68]
Nicotine DMWX5CO Nicotine dependence 6C4A.2 Approved [69]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [70]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [71]
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Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Bacterial infection 1A00-1C4Z Approved [72]
Progesterone DMUY35B Premature labour JB00 Approved [56]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [73]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [74]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [52]
Verapamil DMA7PEW Hypertension BA00-BA04 Approved [75]
Diclofenac DMPIHLS Osteoarthritis FA00-FA05 Approved [76]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [77]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Bacterial infection 1A00-1C4Z Approved [79]
Doxorubicin DMVP5YE Solid tumour/cancer 2A00-2F9Z Approved [80]
Methotrexate DM2TEOL leukaemia 2A60-2B33 Approved [81]
Folic acid DMEMBJC Folate-deficiency anemia 3A02.Y Approved [82]
Fluorouracil DMUM7HZ Solid tumour/cancer 2A00-2F9Z Approved [81]
Cisplatin DMRHGI9 Solid tumour/cancer 2A00-2F9Z Approved [81]
Progesterone DMUY35B Premature labour JB00 Approved [83]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [81]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [84]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [85]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Serotonin transporter (SERT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Pain MG30-MG3Z Approved [86]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [87]
Vortioxetine DM6F1PU Major depressive disorder 6A70.3 Approved [88]
Sertraline DM0FB1J Depression 6A70-6A7Z Approved [89]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [90]
Bupropion DM5PCS7 Smoking dependence 6C4A.2 Approved [91]
Citalopram DM2G9AE Depression 6A70-6A7Z Approved [3]
Nortriptyline DM4KDYJ Depression 6A70-6A7Z Approved [3]
Trazodone DMK1GBJ Depression 6A70-6A7Z Approved [3]
Paroxetine DM5PVQE Depression 6A70-6A7Z Approved [3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Serotonin transporter (SERT) TT3ROYC SC6A4_HUMAN Modulator [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [5]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Substrate [6]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [7]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [8]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [9]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [10]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [7]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Substrate [11]

References

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41 Drug Interactions Flockhart Table
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