Details of the Drug Combination

General Information of Drug Combination (ID: DC2JB7Q)

• Drug Combination Name: PDX-101 + Gemcitabine
• Indication: PTCL; Status: Phase 2 [1]
• Component Drugs:
  PDX-101 (DM6OC53): Small molecular drug
  Gemcitabine (DMSE3I7): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of PDX-101

Disease Entry	ICD 11	Status	REF
Plasma cell myeloma	2A83.1	Approved	[2]
Primary cutaneous peripheral T-cell lymphoma not otherwise specified	N.A.	Approved	[2]
Primary cutaneous T-cell lymphoma	N.A.	Approved	[2]
Solid tumour/cancer	2A00-2F9Z	Phase 2	[3]
Haematological malignancy	2B33.Y	Phase 1	[4]
Peripheral T-cell lymphoma	2A90.C	Phase 1	[4]

PDX-101 Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Histone deacetylase (HDAC)	TTBH0VX	NOUNIPROTAC	Modulator	[14]

PDX-101 Interacts with 2 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[9]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Metabolism	[15]

PDX-101 Interacts with 566 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Aurora kinase A (AURKA)	OTMX0HYT	AURKA_HUMAN	Decreases Expression	[10]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[10]
Transforming acidic coiled-coil-containing protein 1 (TACC1)	OTGX20TE	TACC1_HUMAN	Increases Expression	[10]
Tyrosine-protein kinase ABL1 (ABL1)	OT09YVXH	ABL1_HUMAN	Decreases Expression	[10]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Decreases Expression	[10]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Decreases Expression	[10]
Histone H1.0 (H1-0)	OTRLJK4Z	H10_HUMAN	Increases Expression	[10]
Clusterin (CLU)	OTQGG0JM	CLUS_HUMAN	Increases Expression	[10]
Cyclin-dependent kinase 4 (CDK4)	OT7EP05T	CDK4_HUMAN	Decreases Expression	[10]
Ornithine decarboxylase (ODC1)	OTNDAGRR	DCOR_HUMAN	Increases Expression	[10]
G2/mitotic-specific cyclin-B1 (CCNB1)	OT19S7E5	CCNB1_HUMAN	Decreases Expression	[10]
Interferon gamma receptor 1 (IFNGR1)	OTCTQBWW	INGR1_HUMAN	Increases Expression	[10]
CTP synthase 1 (CTPS1)	OTZ9J6ZG	PYRG1_HUMAN	Decreases Expression	[10]
Cyclin-A2 (CCNA2)	OTPHHYZJ	CCNA2_HUMAN	Decreases Expression	[10]
Diamine acetyltransferase 1 (SAT1)	OT52AU22	SAT1_HUMAN	Increases Expression	[10]
DNA replication licensing factor MCM3 (MCM3)	OTOOHQPM	MCM3_HUMAN	Decreases Expression	[10]
DnaJ homolog subfamily B member 1 (DNAJB1)	OTCOSEVH	DNJB1_HUMAN	Increases Expression	[10]
Multifunctional protein CAD (CAD)	OTNCUYYE	PYR1_HUMAN	Decreases Expression	[10]
CCN family member 2 (CCN2)	OTC39NSU	CCN2_HUMAN	Increases Expression	[10]
M-phase inducer phosphatase 2 (CDC25B)	OT12MSRY	MPIP2_HUMAN	Decreases Expression	[10]
DNA replication licensing factor MCM7 (MCM7)	OT6FXC6K	MCM7_HUMAN	Decreases Expression	[10]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[10]
Cyclin-dependent kinase inhibitor 2A (CDKN2A)	OTN0ZWAE	CDN2A_HUMAN	Decreases Expression	[10]
GTP-binding nuclear protein Ran (RAN)	OT2TER5M	RAN_HUMAN	Decreases Expression	[10]
Ras-related C3 botulinum toxin substrate 1 (RAC1)	OTKRO61U	RAC1_HUMAN	Decreases Expression	[10]
Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2)	OTEO98CR	IF4G2_HUMAN	Decreases Expression	[10]
Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2)	OTFHWIY8	DHRS2_HUMAN	Increases Expression	[10]
Kelch-like ECH-associated protein 1 (KEAP1)	OTFHOD0C	KEAP1_HUMAN	Decreases Expression	[10]
Importin subunit beta-1 (KPNB1)	OTBT2HFL	IMB1_HUMAN	Decreases Expression	[10]
Retrotransposon-derived protein PEG10 (PEG10)	OTWD2278	PEG10_HUMAN	Increases Expression	[10]
Histone H1.10 (H1-10)	OTBWDA4E	H1X_HUMAN	Increases Expression	[10]
Aurora kinase B (AURKB)	OTIY4VHU	AURKB_HUMAN	Decreases Expression	[10]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)	OTUYHB84	MLP3B_HUMAN	Increases Expression	[10]
Inner centromere protein (INCENP)	OT9HFRYK	INCE_HUMAN	Decreases Expression	[10]
Nucleolar RNA helicase 2 (DDX21)	OTV73GMZ	DDX21_HUMAN	Decreases Expression	[10]
Bcl-2-associated transcription factor 1 (BCLAF1)	OT7T8H6A	BCLF1_HUMAN	Decreases Expression	[10]
Protein RCC2 (RCC2)	OTUJVTLS	RCC2_HUMAN	Decreases Expression	[10]
Targeting protein for Xklp2 (TPX2)	OTWLJYH0	TPX2_HUMAN	Decreases Expression	[10]
Proliferation-associated protein 2G4 (PA2G4)	OT7IG7HT	PA2G4_HUMAN	Decreases Expression	[10]
Rho guanine nucleotide exchange factor 37 (ARHGEF37)	OTXQSCDO	ARH37_HUMAN	Decreases Expression	[11]
Homeobox protein HMX2 (HMX2)	OTBRXY6D	HMX2_HUMAN	Increases Expression	[11]
Developmental pluripotency-associated 5 protein (DPPA5)	OTLZC371	DPPA5_HUMAN	Increases Expression	[11]
RNA binding protein fox-1 homolog 3 (RBFOX3)	OTL0F3D6	RFOX3_HUMAN	Decreases Expression	[11]
Transmembrane protein 221 (TMEM221)	OTNSYQ3L	TM221_HUMAN	Decreases Expression	[11]
Coiled-coil domain-containing protein 69 (CCDC69)	OT43MI0R	CCD69_HUMAN	Increases Expression	[11]
Rab GTPase-activating protein 1-like, isoform 10 (RABGAP1L)	OT7QO47I	RBG10_HUMAN	Increases Expression	[11]
Suppressyn (ERVH48-1)	OT303JGE	SUPYN_HUMAN	Increases Expression	[11]
PDZ and LIM domain protein 1 (PDLIM1)	OT4EGCPG	PDLI1_HUMAN	Increases Expression	[11]
Bone morphogenetic protein receptor type-1B (BMPR1B)	OTGFN0OD	BMR1B_HUMAN	Decreases Expression	[11]
Beta-1,3-N-acetylglucosaminyltransferase manic fringe (MFNG)	OTUX45ZF	MFNG_HUMAN	Decreases Expression	[11]
Podocalyxin (PODXL)	OTPNQXF3	PODXL_HUMAN	Increases Expression	[11]
Astrotactin-1 (ASTN1)	OT23FQIB	ASTN1_HUMAN	Decreases Expression	[11]
Suppressor of cytokine signaling 3 (SOCS3)	OTY183WJ	SOCS3_HUMAN	Decreases Expression	[11]
Neurocan core protein (NCAN)	OT8OO6ZE	NCAN_HUMAN	Decreases Expression	[11]
Neuropilin-1 (NRP1)	OTCGULYV	NRP1_HUMAN	Increases Expression	[11]
Semaphorin-3E (SEMA3E)	OTD4S36H	SEM3E_HUMAN	Increases Expression	[11]
Synaptojanin-2 (SYNJ2)	OTLRHXP1	SYNJ2_HUMAN	Decreases Expression	[11]
DNA-directed RNA polymerase III subunit RPC7 (POLR3G)	OTU3TGQ9	RPC7_HUMAN	Increases Expression	[11]
Cytochrome P450 26A1 (CYP26A1)	OTL1DFWV	CP26A_HUMAN	Increases Expression	[11]
Disintegrin and metalloproteinase domain-containing protein 12 (ADAM12)	OTZKOTDB	ADA12_HUMAN	Decreases Expression	[11]
Phospholipid-transporting ATPase IC (ATP8B1)	OTALGS63	AT8B1_HUMAN	Increases Expression	[11]
Zinc finger protein SNAI2 (SNAI2)	OT7Y8EJ2	SNAI2_HUMAN	Increases Expression	[11]
Integral membrane protein 2A (ITM2A)	OT590V63	ITM2A_HUMAN	Increases Expression	[11]
Plexin-C1 (PLXNC1)	OTJ5XKYY	PLXC1_HUMAN	Decreases Expression	[11]
Gremlin-1 (GREM1)	OTCK4IGV	GREM1_HUMAN	Increases Expression	[11]
Histone H2B type 1-K (H2BC12)	OTQ8V0KG	H2B1K_HUMAN	Decreases Expression	[11]
Protein diaphanous homolog 2 (DIAPH2)	OTBEYFEZ	DIAP2_HUMAN	Increases Expression	[11]
Inward rectifier potassium channel 13 (KCNJ13)	OTG1CNND	KCJ13_HUMAN	Decreases Expression	[11]
Frizzled-7 (FZD7)	OTTK3F6E	FZD7_HUMAN	Increases Expression	[11]
Slit homolog 1 protein (SLIT1)	OT35RBNT	SLIT1_HUMAN	Increases Expression	[11]
Core histone macro-H2A.1 (MACROH2A1)	OTV2DQDD	H2AY_HUMAN	Decreases Expression	[11]
Large neutral amino acids transporter small subunit 3 (SLC43A1)	OTQJQY3S	LAT3_HUMAN	Increases Expression	[11]
Forkhead box protein H1 (FOXH1)	OTEXJ9SL	FOXH1_HUMAN	Increases Expression	[11]
Leukocyte cell-derived chemotaxin 1 (CNMD)	OTHND8EL	CNMD_HUMAN	Increases Expression	[11]
Lysozyme-like protein 6 (LYZL6)	OT6XS67M	LYZL6_HUMAN	Increases Expression	[11]
Slit homolog 2 protein (SLIT2)	OTLS2RJ4	SLIT2_HUMAN	Increases Expression	[11]
Nucleolar protein 4 (NOL4)	OTWI587R	NOL4_HUMAN	Decreases Expression	[11]
Dickkopf-related protein 1 (DKK1)	OTRDLUSP	DKK1_HUMAN	Increases Expression	[11]
Serine protease 23 (PRSS23)	OT6DQAM1	PRS23_HUMAN	Decreases Expression	[11]
Neurexophilin-2 (NXPH2)	OTHD8HPU	NXPH2_HUMAN	Decreases Expression	[11]
Protocadherin-8 (PCDH8)	OTDDOQM2	PCDH8_HUMAN	Increases Expression	[11]
Homeobox protein SIX3 (SIX3)	OTP5E3VU	SIX3_HUMAN	Decreases Expression	[11]
Claudin-7 (CLDN7)	OTNE0XHQ	CLD7_HUMAN	Increases Expression	[11]
C-X-C motif chemokine 14 (CXCL14)	OTM189TA	CXL14_HUMAN	Increases Expression	[11]
BAG family molecular chaperone regulator 2 (BAG2)	OTI6LD27	BAG2_HUMAN	Increases Expression	[11]
Leucine-rich glioma-inactivated protein 1 (LGI1)	OTPS77HO	LGI1_HUMAN	Increases Expression	[11]
Urokinase-type plasminogen activator (PLAU)	OTX0QGKK	UROK_HUMAN	Increases Expression	[11]
Adenosine deaminase (ADA)	OTOX2872	ADA_HUMAN	Decreases Expression	[11]
Pro-neuropeptide Y (NPY)	OT4ICV3P	NPY_HUMAN	Increases Expression	[11]
Alpha-fetoprotein (AFP)	OT9GG3ZI	FETA_HUMAN	Decreases Expression	[11]
Endothelin-1 (EDN1)	OTZCACEG	EDN1_HUMAN	Increases Expression	[11]
Transcription factor AP-2-alpha (TFAP2A)	OTMYT3NK	AP2A_HUMAN	Increases Expression	[11]
Keratin, type I cytoskeletal 18 (KRT18)	OTVLQFIP	K1C18_HUMAN	Increases Expression	[11]
Calbindin (CALB1)	OTM7IXDG	CALB1_HUMAN	Increases Expression	[11]
Neurofilament light polypeptide (NEFL)	OTQESJV4	NFL_HUMAN	Increases Expression	[11]
Annexin A2 (ANXA2)	OTFNS0CC	ANXA2_HUMAN	Increases Expression	[11]
Collagen alpha-2(I) chain (COL1A2)	OTY7G382	CO1A2_HUMAN	Increases Expression	[11]
Inhibin beta A chain (INHBA)	OTSP64PQ	INHBA_HUMAN	Increases Expression	[11]
Fibroblast growth factor 4 (FGF4)	OTNVV3ZG	FGF4_HUMAN	Increases Expression	[11]
Tumor-associated calcium signal transducer 2 (TACSTD2)	OTLSZR00	TACD2_HUMAN	Increases Expression	[11]
Apelin receptor early endogenous ligand (APELA)	OTYY0P69	ELA_HUMAN	Increases Expression	[11]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[11]
Chromogranin-A (CHGA)	OTXYX5JH	CMGA_HUMAN	Increases Expression	[11]
Tissue factor pathway inhibitor (TFPI)	OTA0FX16	TFPI1_HUMAN	Increases Expression	[11]
Thyroid hormone receptor beta (THRB)	OTBBIRHZ	THB_HUMAN	Increases Expression	[11]
Hyaluronan and proteoglycan link protein 1 (HAPLN1)	OTXWR9TJ	HPLN1_HUMAN	Increases Expression	[11]
Serine/threonine-protein kinase pim-1 (PIM1)	OTWEKXTU	PIM1_HUMAN	Increases Expression	[11]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Increases Expression	[11]
Protein Cripto (CRIPTO)	OT46DZXJ	TDGF1_HUMAN	Increases Expression	[11]
Phospholipase A2, membrane associated (PLA2G2A)	OT1NY7BF	PA2GA_HUMAN	Increases Expression	[11]
Protein C-ets-1 (ETS1)	OT4LVGDN	ETS1_HUMAN	Increases Expression	[11]
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Increases Expression	[11]
NAD(P)H dehydrogenase 1 (NQO1)	OTZGGIVK	NQO1_HUMAN	Increases Expression	[11]
Epithelial cell adhesion molecule (EPCAM)	OTHBZK5X	EPCAM_HUMAN	Increases Expression	[11]
Atrial natriuretic peptide receptor 3 (NPR3)	OT6MQP3A	ANPRC_HUMAN	Increases Expression	[11]
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)	OTAKDCMR	KAPCA_HUMAN	Increases Expression	[11]
Neuromodulin (GAP43)	OT2OTGGV	NEUM_HUMAN	Increases Expression	[11]
Vascular endothelial growth factor receptor 1 (FLT1)	OTT0OGYS	VGFR1_HUMAN	Increases Expression	[11]
Integrin beta-5 (ITGB5)	OT21MF51	ITB5_HUMAN	Decreases Expression	[11]
Pituitary adenylate cyclase-activating polypeptide (ADCYAP1)	OT0LQH93	PACA_HUMAN	Increases Expression	[11]
Alpha-1-acid glycoprotein 2 (ORM2)	OTRJGZP8	A1AG2_HUMAN	Decreases Expression	[11]
Serine protease inhibitor Kazal-type 2 (SPINK2)	OTSFBT0G	ISK2_HUMAN	Increases Expression	[11]
Muscarinic acetylcholine receptor M3 (CHRM3)	OTKSD095	ACM3_HUMAN	Increases Expression	[11]
Ephrin-A1 (EFNA1)	OTU2NUA2	EFNA1_HUMAN	Increases Expression	[11]
Ephrin type-A receptor 1 (EPHA1)	OTGJMRZ0	EPHA1_HUMAN	Increases Expression	[11]
CD9 antigen (CD9)	OT2184XU	CD9_HUMAN	Increases Expression	[11]
Bone morphogenetic protein 5 (BMP5)	OTC0Y6E0	BMP5_HUMAN	Increases Expression	[11]
Cadherin-3 (CDH3)	OTKNLQU7	CADH3_HUMAN	Increases Expression	[11]
Fibulin-1 (FBLN1)	OT5MHHOP	FBLN1_HUMAN	Decreases Expression	[11]
Paired box protein Pax-7 (PAX7)	OTDMQRPO	PAX7_HUMAN	Increases Expression	[11]
Paired box protein Pax-3 (PAX3)	OTN5PJZV	PAX3_HUMAN	Increases Expression	[11]
Trans-acting T-cell-specific transcription factor GATA-3 (GATA3)	OTGP7D5Y	GATA3_HUMAN	Increases Expression	[11]
Endothelin receptor type B (EDNRB)	OTLLZV3P	EDNRB_HUMAN	Increases Expression	[11]
Tenascin (TNC)	OTK4FSHR	TENA_HUMAN	Decreases Expression	[11]
Signal transducer CD24 (CD24)	OT7CODJ4	CD24_HUMAN	Increases Expression	[11]
Endothelin-1 receptor (EDNRA)	OTK9T5O3	EDNRA_HUMAN	Increases Expression	[11]
Rhombotin-2 (LMO2)	OTCC370G	RBTN2_HUMAN	Decreases Expression	[11]
Pentraxin-related protein PTX3 (PTX3)	OTPXHRKU	PTX3_HUMAN	Decreases Expression	[11]
HLA class II histocompatibility antigen, DM beta chain (HLA-DMB)	OT17HGXJ	DMB_HUMAN	Decreases Expression	[11]
Homeobox protein MSX-1 (MSX1)	OT5U41ZP	MSX1_HUMAN	Increases Expression	[11]
Gamma-aminobutyric acid receptor subunit beta-3 (GABRB3)	OT80C3D4	GBRB3_HUMAN	Increases Expression	[11]
Ephrin type-A receptor 3 (EPHA3)	OTZJF3ML	EPHA3_HUMAN	Increases Expression	[11]
Ephrin type-B receptor 2 (EPHB2)	OT8VZ6C5	EPHB2_HUMAN	Decreases Expression	[11]
G1/S-specific cyclin-D2 (CCND2)	OTDULQF9	CCND2_HUMAN	Decreases Expression	[11]
Fibroblast growth factor 9 (FGF9)	OT2SKDGM	FGF9_HUMAN	Decreases Expression	[11]
Gastrin/cholecystokinin type B receptor (CCKBR)	OTQSNXOI	GASR_HUMAN	Decreases Expression	[11]
Neuronal acetylcholine receptor subunit alpha-3 (CHRNA3)	OTCZQY1U	ACHA3_HUMAN	Increases Expression	[11]
Homeobox protein MSX-2 (MSX2)	OT1WDKE1	MSX2_HUMAN	Increases Expression	[11]
Metalloproteinase inhibitor 3 (TIMP3)	OTDGQAD1	TIMP3_HUMAN	Decreases Expression	[11]
Vascular endothelial growth factor receptor 2 (KDR)	OT15797V	VGFR2_HUMAN	Increases Expression	[11]
Amiloride-sensitive sodium channel subunit alpha (SCNN1A)	OTE2KVZV	SCNNA_HUMAN	Increases Expression	[11]
C-X-C motif chemokine 5 (CXCL5)	OTZOUPCA	CXCL5_HUMAN	Increases Expression	[11]
Lysophosphatidic acid receptor 6 (LPAR6)	OT4BY3W4	LPAR6_HUMAN	Increases Expression	[11]
Peptidyl-prolyl cis-trans isomerase C (PPIC)	OTY5Q42N	PPIC_HUMAN	Increases Expression	[11]
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (ACADSB)	OTDO6HBG	ACDSB_HUMAN	Increases Expression	[11]
Cytosolic phospholipase A2 (PLA2G4A)	OTE70SOT	PA24A_HUMAN	Increases Expression	[11]
DNA-binding protein inhibitor ID-4 (ID4)	OTPMJ39I	ID4_HUMAN	Increases Expression	[11]
Protein ERGIC-53 (LMAN1)	OTYHKDEO	LMAN1_HUMAN	Decreases Expression	[11]
Beta-arrestin-1 (ARRB1)	OT2NJS37	ARRB1_HUMAN	Increases Expression	[11]
Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A)	OT5QQB5L	IDH3A_HUMAN	Increases Expression	[11]
Homeobox protein MOX-1 (MEOX1)	OTJEMT2D	MEOX1_HUMAN	Increases Expression	[11]
Cysteine-rich protein 1 (CRIP1)	OT0EICG3	CRIP1_HUMAN	Increases Expression	[11]
Serpin B9 (SERPINB9)	OTJ811IF	SPB9_HUMAN	Increases Expression	[11]
LIM/homeobox protein Lhx2 (LHX2)	OTK61NP8	LHX2_HUMAN	Decreases Expression	[11]
Probable global transcription activator SNF2L2 (SMARCA2)	OTSGJ8SV	SMCA2_HUMAN	Increases Expression	[11]
Beta-crystallin A4 (CRYBA4)	OTQJ5XGE	CRBA4_HUMAN	Decreases Expression	[11]
GDNF family receptor alpha-1 (GFRA1)	OT3WBVYB	GFRA1_HUMAN	Decreases Expression	[11]
Transcription factor SOX-8 (SOX8)	OTEJXYZM	SOX8_HUMAN	Increases Expression	[11]
Sestrin-3 (SESN3)	OTJRY1Y5	SESN3_HUMAN	Increases Expression	[11]
Neurexin-2-beta (NRXN2)	OTB04QSU	NRX2B_HUMAN	Decreases Expression	[11]
Histone H2B type 1-D (H2BC5)	OTXDTDHN	H2B1D_HUMAN	Decreases Expression	[11]
Synaptosomal-associated protein 25 (SNAP25)	OTUIQ81Q	SNP25_HUMAN	Increases Expression	[11]
Protein S100-A10 (S100A10)	OTI71243	S10AA_HUMAN	Increases Expression	[11]
Somatostatin (SST)	OTY75GQH	SMS_HUMAN	Increases Expression	[11]
Neurocalcin-delta (NCALD)	OTJZ8UEL	NCALD_HUMAN	Decreases Expression	[11]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 (GNG11)	OTHIXBGW	GBG11_HUMAN	Increases Expression	[11]
Rho-related GTP-binding protein RhoB (RHOB)	OTHQFQF7	RHOB_HUMAN	Increases Expression	[11]
Iroquois-class homeodomain protein IRX-1 (IRX1)	OT0ZN9EJ	IRX1_HUMAN	Increases Expression	[11]
Reelin (RELN)	OTLKMW1O	RELN_HUMAN	Increases Expression	[11]
Nucleobindin-2 (NUCB2)	OTHO6JWN	NUCB2_HUMAN	Decreases Expression	[11]
Serine beta-lactamase-like protein LACTB, mitochondrial (LACTB)	OTRWGNBF	LACTB_HUMAN	Increases Expression	[11]
Norrin (NDP)	OTGDJ4US	NDP_HUMAN	Decreases Expression	[11]
POU domain, class 5, transcription factor 1 (POU5F1)	OTDHHN7O	PO5F1_HUMAN	Increases Expression	[11]
Hematopoietically-expressed homeobox protein HHEX (HHEX)	OTLIUVYX	HHEX_HUMAN	Increases Expression	[11]
Putative POU domain, class 5, transcription factor 1B (POU5F1B)	OT0FKQ51	P5F1B_HUMAN	Increases Expression	[11]
Protein CBFA2T1 (RUNX1T1)	OT30DED5	MTG8_HUMAN	Increases Expression	[11]
Forkhead box protein O1 (FOXO1)	OTPJRB6D	FOXO1_HUMAN	Increases Expression	[11]
Contactin-1 (CNTN1)	OT7RNPEY	CNTN1_HUMAN	Increases Expression	[11]
Noggin (NOG)	OTGRHHPG	NOGG_HUMAN	Increases Expression	[11]
N-myc-interactor (NMI)	OTYVG3NM	NMI_HUMAN	Increases Expression	[11]
Frizzled-5 (FZD5)	OTXFFY56	FZD5_HUMAN	Decreases Expression	[11]
Cadherin-18 (CDH18)	OTC06P9H	CAD18_HUMAN	Increases Expression	[11]
Krueppel-like factor 5 (KLF5)	OT1ABI9N	KLF5_HUMAN	Increases Expression	[11]
Septin-6 (SEPTIN6)	OTIV9RTK	SEPT6_HUMAN	Increases Expression	[11]
Transcription factor E2F2 (E2F2)	OTO75RM7	E2F2_HUMAN	Decreases Expression	[11]
Polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3)	OT7M67WT	GALT3_HUMAN	Increases Expression	[11]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Expression	[11]
Uncharacterized protein KIAA0040 (KIAA0040)	OT27EBY3	K0040_HUMAN	Increases Expression	[11]
Ephrin type-A receptor 7 (EPHA7)	OT3VC211	EPHA7_HUMAN	Increases Expression	[11]
Angiopoietin-1 (ANGPT1)	OTVZ1NG3	ANGP1_HUMAN	Increases Expression	[11]
Myosin light chain kinase, smooth muscle (MYLK)	OT78QB4A	MYLK_HUMAN	Decreases Expression	[11]
Metallophosphoesterase MPPED2 (MPPED2)	OT7XLMJ6	MPPD2_HUMAN	Decreases Expression	[11]
Laminin subunit alpha-4 (LAMA4)	OTHI7TA0	LAMA4_HUMAN	Increases Expression	[11]
Gamma-interferon-inducible protein 16 (IFI16)	OT4SPU0U	IF16_HUMAN	Increases Expression	[11]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Increases Expression	[11]
Reticulon-1 (RTN1)	OTCX1SMK	RTN1_HUMAN	Decreases Expression	[11]
Tumor protein D53 (TPD52L1)	OTSA6U0I	TPD53_HUMAN	Increases Expression	[11]
Complement component receptor 1-like protein (CR1L)	OTX3KR7U	CR1L_HUMAN	Increases Expression	[11]
Cell cycle control protein 50B (TMEM30B)	OTNSBH84	CC50B_HUMAN	Increases Expression	[11]
Protein shisa-like-1 (SHISAL1)	OTOIUVC4	SHSL1_HUMAN	Decreases Expression	[11]
Protein PTHB1 (BBS9)	OT23V9YF	PTHB1_HUMAN	Increases Expression	[11]
Uncharacterized protein C8orf34 (C8ORF34)	OTXCTHDG	CH034_HUMAN	Increases Expression	[11]
F-box only protein 43 (FBXO43)	OT6ST2A4	FBX43_HUMAN	Decreases Expression	[11]
Extracellular tyrosine-protein kinase PKDCC (PKDCC)	OTVXJR26	PKDCC_HUMAN	Increases Expression	[11]
Seizure protein 6 homolog (SEZ6)	OTCD8K5D	SEZ6_HUMAN	Increases Expression	[11]
Pleckstrin homology-like domain family A member 2 (PHLDA2)	OTMV9DPP	PHLA2_HUMAN	Increases Expression	[11]
Fibulin-7 (FBLN7)	OT1XRDP6	FBLN7_HUMAN	Decreases Expression	[11]
Protein BEX5 (BEX5)	OTZ2RB6L	BEX5_HUMAN	Increases Expression	[11]
Collectin-12 (COLEC12)	OTIQTK9G	COL12_HUMAN	Increases Expression	[11]
Solute carrier family 35 member D3 (SLC35D3)	OTHKRBGM	S35D3_HUMAN	Increases Expression	[11]
Centrosomal protein of 85 kDa-like (CEP85L)	OTSHJFOT	CE85L_HUMAN	Increases Expression	[11]
Protein FAM162B (FAM162B)	OTZ31RP5	F162B_HUMAN	Increases Expression	[11]
Transcription factor HES-5 (HES5)	OTW7JEHV	HES5_HUMAN	Decreases Expression	[11]
Protein FAM222A (FAM222A)	OTRD9AUH	F222A_HUMAN	Decreases Expression	[11]
Scm-like with four MBT domains protein 2 (SFMBT2)	OTZQT61Q	SMBT2_HUMAN	Increases Expression	[11]
LIM/homeobox protein Lhx8 (LHX8)	OT0DFL7C	LHX8_HUMAN	Increases Expression	[11]
TMF-regulated nuclear protein 1 (TRNP1)	OTYYV8LN	TRNP1_HUMAN	Increases Expression	[11]
Lactase-like protein (LCTL)	OTN36T21	LCTL_HUMAN	Decreases Expression	[11]
Interleukin-20 receptor subunit beta (IL20RB)	OTHFXK95	I20RB_HUMAN	Increases Expression	[11]
Transmembrane protein 64 (TMEM64)	OTO9IDFD	TMM64_HUMAN	Increases Expression	[11]
Metastasis-associated in colon cancer protein 1 (MACC1)	OTV3DLX0	MACC1_HUMAN	Increases Expression	[11]
Zinc finger protein basonuclin-2 (BNC2)	OTU22H9Z	BNC2_HUMAN	Increases Expression	[11]
Solute carrier organic anion transporter family member 4C1 (SLCO4C1)	OTVILUUN	SO4C1_HUMAN	Increases Expression	[11]
Leucine-rich repeat-containing protein 55 (LRRC55)	OT8LQI1W	LRC55_HUMAN	Decreases Expression	[11]
UPF0606 protein KIAA1549L (KIAA1549L)	OT80HUVY	K154L_HUMAN	Decreases Expression	[11]
Monocarboxylate transporter 14 (SLC16A14)	OTUGDEUV	MOT14_HUMAN	Decreases Expression	[11]
E3 ubiquitin-protein ligase RNF144B (RNF144B)	OTN7FCDE	R144B_HUMAN	Increases Expression	[11]
Developmental pluripotency-associated protein 2 (DPPA2)	OT8Y55RY	DPPA2_HUMAN	Increases Expression	[11]
Uncharacterized protein C11orf96 (C11ORF96)	OTEQU0V7	CK096_HUMAN	Increases Expression	[11]
Sodium/hydrogen exchanger 9B2 (SLC9B2)	OTZVOY8T	SL9B2_HUMAN	Decreases Expression	[11]
Leucine-rich repeat transmembrane neuronal protein 1 (LRRTM1)	OTKI3IU9	LRRT1_HUMAN	Increases Expression	[11]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (MAGI2)	OTXDDKZS	MAGI2_HUMAN	Increases Expression	[11]
Inter-alpha-trypsin inhibitor heavy chain H5 (ITIH5)	OTP46PZM	ITIH5_HUMAN	Increases Expression	[11]
Catechol O-methyltransferase domain-containing protein 1 (COMTD1)	OTLQJTBI	CMTD1_HUMAN	Increases Expression	[11]
Protein phosphatase 1 regulatory subunit 3B (PPP1R3B)	OTVCRXEZ	PPR3B_HUMAN	Increases Expression	[11]
Podoplanin (PDPN)	OTBUV19I	PDPN_HUMAN	Increases Expression	[11]
Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPARGC1B)	OTN6FKCB	PRGC2_HUMAN	Increases Expression	[11]
Neuron navigator 3 (NAV3)	OT97M1TR	NAV3_HUMAN	Increases Expression	[11]
Procollagen galactosyltransferase 2 (COLGALT2)	OTV9EDZB	GT252_HUMAN	Decreases Expression	[11]
Ras and EF-hand domain-containing protein (RASEF)	OTGSAM2E	RASEF_HUMAN	Increases Expression	[11]
Solute carrier family 38 member 6 (SLC38A6)	OTIC8SHQ	S38A6_HUMAN	Increases Expression	[11]
Protein SIX6OS1 (C14ORF39)	OTFKQ6HO	S6OS1_HUMAN	Decreases Expression	[11]
Rho GTPase-activating protein 24 (ARHGAP24)	OTCQCEZS	RHG24_HUMAN	Increases Expression	[11]
Protein FAM43A (FAM43A)	OT5RPQRE	FA43A_HUMAN	Increases Expression	[11]
ELMO domain-containing protein 1 (ELMOD1)	OT0WRVJC	ELMD1_HUMAN	Increases Expression	[11]
Mucin-15 (MUC15)	OT3PQT6L	MUC15_HUMAN	Increases Expression	[11]
Chemokine-like protein TAFA-2 (TAFA2)	OTU6WP6J	TAFA2_HUMAN	Increases Expression	[11]
Protein phosphatase Mn(2+)-dependent 1K (PPM1K)	OTNZ4N4E	PPM1K_HUMAN	Increases Expression	[11]
Thioredoxin domain-containing protein 3 (NME8)	OT4RULP5	TXND3_HUMAN	Increases Expression	[11]
Leucine-rich repeat-containing protein 17 (LRRC17)	OT3NZSX3	LRC17_HUMAN	Increases Expression	[11]
Inactive phospholipase D5 (PLD5)	OTEVPYNY	PLD5_HUMAN	Decreases Expression	[11]
BMP-binding endothelial regulator protein (BMPER)	OTBYON4H	BMPER_HUMAN	Increases Expression	[11]
Tandem C2 domains nuclear protein (TC2N)	OT6482WN	TAC2N_HUMAN	Increases Expression	[11]
Tetratricopeptide repeat protein 29 (TTC29)	OT37KCUL	TTC29_HUMAN	Increases Expression	[11]
Neuropilin and tolloid-like protein 2 (NETO2)	OT0YAMC0	NETO2_HUMAN	Decreases Expression	[11]
Beta-galactosidase-1-like protein 3 (GLB1L3)	OTWAWGX4	GLBL3_HUMAN	Increases Expression	[11]
Zinc finger protein GLIS3 (GLIS3)	OTBC960E	GLIS3_HUMAN	Decreases Expression	[11]
Interleukin-17 receptor D (IL17RD)	OTKD9XST	I17RD_HUMAN	Decreases Expression	[11]
Delta and Notch-like epidermal growth factor-related receptor (DNER)	OT2GH2E5	DNER_HUMAN	Increases Expression	[11]
Semaphorin-6D (SEMA6D)	OTU0UAZS	SEM6D_HUMAN	Decreases Expression	[11]
LIM domain only protein 3 (LMO3)	OTR7AJHN	LMO3_HUMAN	Decreases Expression	[11]
DEP domain-containing mTOR-interacting protein (DEPTOR)	OTCBP1BT	DPTOR_HUMAN	Increases Expression	[11]
E3 ubiquitin-protein ligase RNF217 (RNF217)	OTAX91ES	RN217_HUMAN	Increases Expression	[11]
Ciliary microtubule-associated protein 3 (CIMAP3)	OT8RL1WO	CMAP3_HUMAN	Increases Expression	[11]
Mucolipin-3 (MCOLN3)	OTCRPRVS	MCLN3_HUMAN	Increases Expression	[11]
Grainyhead-like protein 3 homolog (GRHL3)	OT1V4ZEH	GRHL3_HUMAN	Increases Expression	[11]
DENN domain-containing protein 1A (DENND1A)	OTONDAA0	DEN1A_HUMAN	Decreases Expression	[11]
Pleckstrin homology-like domain family A member 1 (PHLDA1)	OTFTWMIQ	PHLA1_HUMAN	Increases Expression	[11]
Secretogranin-3 (SCG3)	OTUYSV2S	SCG3_HUMAN	Increases Expression	[11]
Myosin-IIIb (MYO3B)	OTVD4TNG	MYO3B_HUMAN	Increases Expression	[11]
E3 ubiquitin-protein ligase MYLIP (MYLIP)	OTL0PFGV	MYLIP_HUMAN	Increases Expression	[11]
Transcription factor AP-2-beta (TFAP2B)	OTR1T8E9	AP2B_HUMAN	Increases Expression	[11]
Piezo-type mechanosensitive ion channel component 1 (PIEZO1)	OTBG1FU4	PIEZ1_HUMAN	Decreases Expression	[11]
Transcription factor AP-2 gamma (TFAP2C)	OTUDIW05	AP2C_HUMAN	Increases Expression	[11]
Deleted in azoospermia-like (DAZL)	OTZMTD4R	DAZL_HUMAN	Decreases Expression	[11]
Stathmin-2 (STMN2)	OT0FUHLH	STMN2_HUMAN	Increases Expression	[11]
Sodium-coupled neutral amino acid transporter 4 (SLC38A4)	OTV5OHBT	S38A4_HUMAN	Increases Expression	[11]
Copine-4 (CPNE4)	OTTAGM5L	CPNE4_HUMAN	Increases Expression	[11]
Serine/threonine-protein kinase Sgk3 (SGK3)	OTQ6QO99	SGK3_HUMAN	Increases Expression	[11]
Collagen triple helix repeat-containing protein 1 (CTHRC1)	OTV88X2G	CTHR1_HUMAN	Increases Expression	[11]
Ras-related protein Rab-3C (RAB3C)	OTFTJNGA	RAB3C_HUMAN	Increases Expression	[11]
BLOC-1-related complex subunit 8 (BORCS8)	OTVRSVCB	BORC8_HUMAN	Increases Expression	[11]
Serine dehydratase-like (SDSL)	OTGZEAGJ	SDSL_HUMAN	Decreases Expression	[11]
Calmodulin-like protein 4 (CALML4)	OT6DD5EW	CALL4_HUMAN	Decreases Expression	[11]
4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL)	OTW7D1SV	HPDL_HUMAN	Increases Expression	[11]
Microtubule-associated protein 6 (MAP6)	OTPUI00F	MAP6_HUMAN	Decreases Expression	[11]
TOX high mobility group box family member 2 (TOX2)	OT7RZRVK	TOX2_HUMAN	Decreases Expression	[11]
Collagen alpha-1(XXI) chain (COL21A1)	OT7GS82E	COLA1_HUMAN	Increases Expression	[11]
Noelin-3 (OLFM3)	OTBHPDTL	NOE3_HUMAN	Increases Expression	[11]
Secretoglobin family 3A member 2 (SCGB3A2)	OTB63PHR	SG3A2_HUMAN	Increases Expression	[11]
DEP domain-containing protein 7 (DEPDC7)	OT62C942	DEPD7_HUMAN	Increases Expression	[11]
MAP7 domain-containing protein 2 (MAP7D2)	OTN85925	MA7D2_HUMAN	Decreases Expression	[11]
Glutamate decarboxylase 1 (GAD1)	OT52Z39J	DCE1_HUMAN	Increases Expression	[11]
Protein kinase C-binding protein NELL2 (NELL2)	OTS4MJZ7	NELL2_HUMAN	Decreases Expression	[11]
Sphingosine 1-phosphate receptor 3 (S1PR3)	OTXBIYO8	S1PR3_HUMAN	Decreases Expression	[11]
Neuroserpin (SERPINI1)	OTUJHIJW	NEUS_HUMAN	Increases Expression	[11]
Pituitary homeobox 2 (PITX2)	OTWMXAOY	PITX2_HUMAN	Increases Expression	[11]
Forkhead box protein C2 (FOXC2)	OT83P1E0	FOXC2_HUMAN	Increases Expression	[11]
Retinoic acid receptor responder protein 2 (RARRES2)	OT1BJE8K	RARR2_HUMAN	Increases Expression	[11]
Semaphorin-3C (SEMA3C)	OTEGUY7F	SEM3C_HUMAN	Increases Expression	[11]
Microtubule-associated proteins 1A/1B light chain 3C (MAP1LC3C)	OTM4ECDK	MLP3C_HUMAN	Increases Expression	[11]
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (B3GNT5)	OTA0DE43	B3GN5_HUMAN	Decreases Expression	[11]
Anoctamin-3 (ANO3)	OTM34U6Q	ANO3_HUMAN	Increases Expression	[11]
Iroquois-class homeodomain protein IRX-2 (IRX2)	OTBHXXQ2	IRX2_HUMAN	Increases Expression	[11]
PR domain zinc finger protein 14 (PRDM14)	OTWZKY4L	PRD14_HUMAN	Increases Expression	[11]
AP-5 complex subunit mu-1 (AP5M1)	OTDLWEBL	AP5M1_HUMAN	Increases Expression	[11]
B-cell lymphoma/leukemia 11A (BCL11A)	OTI6ZBP6	BC11A_HUMAN	Increases Expression	[11]
Serine/threonine-protein kinase TAO3 (TAOK3)	OTYBATSH	TAOK3_HUMAN	Increases Expression	[11]
Leucine-rich repeat neuronal protein 3 (LRRN3)	OT7X0AA7	LRRN3_HUMAN	Increases Expression	[11]
SPARC-related modular calcium-binding protein 1 (SMOC1)	OTJG2JQY	SMOC1_HUMAN	Decreases Expression	[11]
Nuclear body protein SP140-like protein (SP140L)	OTL30JKT	SP14L_HUMAN	Increases Expression	[11]
Chondrolectin (CHODL)	OTVCNOUQ	CHODL_HUMAN	Increases Expression	[11]
Homeobox protein NANOG (NANOG)	OTUEY1FM	NANOG_HUMAN	Increases Expression	[11]
Adhesion G protein-coupled receptor L3 (ADGRL3)	OT81Q8LY	AGRL3_HUMAN	Decreases Expression	[11]
Roundabout homolog 2 (ROBO2)	OTFJ9FQW	ROBO2_HUMAN	Decreases Expression	[11]
Band 4.1-like protein 5 (EPB41L5)	OTPPQPLU	E41L5_HUMAN	Increases Expression	[11]
Olfactomedin-like protein 3 (OLFML3)	OTDN45FN	OLFL3_HUMAN	Increases Expression	[11]
Homer protein homolog 2 (HOMER2)	OT4JGKJF	HOME2_HUMAN	Decreases Expression	[11]
Muscleblind-like protein 3 (MBNL3)	OT2T2YOK	MBNL3_HUMAN	Increases Expression	[11]
Very long chain fatty acid elongase 2 (ELOVL2)	OTDAF6U3	ELOV2_HUMAN	Decreases Expression	[11]
Dapper homolog 1 (DACT1)	OT19Z704	DACT1_HUMAN	Increases Expression	[11]
Neuroligin-3 (NLGN3)	OTKDEC1Q	NLGN3_HUMAN	Decreases Expression	[11]
Myoferlin (MYOF)	OTRFC3IJ	MYOF_HUMAN	Increases Expression	[11]
Peroxisomal sarcosine oxidase (PIPOX)	OTWTCOTN	SOX_HUMAN	Increases Expression	[11]
Docking protein 5 (DOK5)	OT2XWUPN	DOK5_HUMAN	Increases Expression	[11]
Contactin-3 (CNTN3)	OTC1274J	CNTN3_HUMAN	Decreases Expression	[11]
Protocadherin-10 (PCDH10)	OT2GIT0E	PCD10_HUMAN	Increases Expression	[11]
Centrosomal protein of 126 kDa (CEP126)	OTUMFEME	CE126_HUMAN	Increases Expression	[11]
Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2)	OTU4J3ZI	HEY2_HUMAN	Increases Expression	[11]
Homeobox expressed in ES cells 1 (HESX1)	OT5E2Z4G	HESX1_HUMAN	Decreases Expression	[11]
Forkhead box protein D3 (FOXD3)	OTXYV6GO	FOXD3_HUMAN	Increases Expression	[11]
TRAF2 and NCK-interacting protein kinase (TNIK)	OTDZBJ4K	TNIK_HUMAN	Increases Expression	[11]
POU domain, class 2, transcription factor 3 (POU2F3)	OTIOOJWD	PO2F3_HUMAN	Increases Expression	[11]
Paraneoplastic antigen Ma2 (PNMA2)	OTF5YBQG	PNMA2_HUMAN	Decreases Expression	[11]
Protein HEG homolog 1 (HEG1)	OT3CUXA7	HEG1_HUMAN	Decreases Expression	[11]
RING finger protein 150 (RNF150)	OTAMSBK5	RN150_HUMAN	Increases Expression	[11]
Sex comb on midleg-like protein 1 (SCML1)	OT7V5DAR	SCML1_HUMAN	Increases Expression	[11]
LIM and calponin homology domains-containing protein 1 (LIMCH1)	OTYPC4XA	LIMC1_HUMAN	Decreases Expression	[11]
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A)	OT74EK7Z	PDE10_HUMAN	Decreases Expression	[11]
C-C motif chemokine 26 (CCL26)	OT2B7HR9	CCL26_HUMAN	Increases Expression	[11]
Band 4.1-like protein 3 (EPB41L3)	OTS6CHG2	E41L3_HUMAN	Increases Expression	[11]
Retinal homeobox protein Rx (RAX)	OTJ3YCE7	RX_HUMAN	Decreases Expression	[11]
Beta/gamma crystallin domain-containing protein 1 (CRYBG1)	OTIPDI15	CRBG1_HUMAN	Increases Expression	[11]
Neuropeptide FF receptor 2 (NPFFR2)	OTVI4Q85	NPFF2_HUMAN	Increases Expression	[11]
Glypican-6 (GPC6)	OTNJBESF	GPC6_HUMAN	Decreases Expression	[11]
Adhesion G-protein coupled receptor G1 (ADGRG1)	OTQBB8NT	AGRG1_HUMAN	Decreases Expression	[11]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1)	OTNEN8QK	SO1B1_HUMAN	Increases Expression	[11]
Dual specificity protein phosphatase 10 (DUSP10)	OTNG467B	DUS10_HUMAN	Increases Expression	[11]
KAT8 regulatory NSL complex subunit 1-like protein (KANSL1L)	OTOAH2RR	KAL1L_HUMAN	Decreases Expression	[12]
Cilia- and flagella-associated protein 119 (CFAP119)	OT7PL1Q6	CF119_HUMAN	Increases Expression	[12]
Leucine-rich repeat-containing protein 10B (LRRC10B)	OT9NKWFW	LR10B_HUMAN	Decreases Expression	[12]
Collagen alpha-6(VI) chain (COL6A6)	OT4MVGRW	CO6A6_HUMAN	Decreases Expression	[12]
Sulfotransferase 1C2 (SULT1C2)	OT07MMZS	ST1C2_HUMAN	Decreases Expression	[12]
Acetyl-CoA carboxylase 2 (ACACB)	OT96UIP1	ACACB_HUMAN	Decreases Expression	[12]
Homeobox protein CDX-4 (CDX4)	OTD1SQKM	CDX4_HUMAN	Decreases Expression	[12]
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3)	OTPGHZB9	IFIT3_HUMAN	Decreases Expression	[12]
Ras-related protein Rab-7L1 (RAB29)	OTDZT6LP	RAB7L_HUMAN	Increases Expression	[12]
Synemin (SYNM)	OTOI8TRJ	SYNEM_HUMAN	Decreases Expression	[12]
A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAMTS3)	OT2U6VF5	ATS3_HUMAN	Decreases Expression	[12]
Angiopoietin-2 (ANGPT2)	OTEQK65P	ANGP2_HUMAN	Decreases Expression	[12]
Cochlin (COCH)	OTBEHD89	COCH_HUMAN	Decreases Expression	[12]
Maltase-glucoamylase (MGAM)	OTVLMDUE	MGA_HUMAN	Decreases Expression	[12]
Protocadherin-7 (PCDH7)	OTP091X8	PCDH7_HUMAN	Decreases Expression	[12]
Protein tyrosine phosphatase type IVA 3 (PTP4A3)	OTXMMWUN	TP4A3_HUMAN	Decreases Expression	[12]
Src kinase-associated phosphoprotein 2 (SKAP2)	OTSF44KP	SKAP2_HUMAN	Increases Expression	[12]
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (GCAT)	OT6WZPWV	KBL_HUMAN	Decreases Expression	[12]
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (B3GALNT1)	OT8GFSQL	B3GL1_HUMAN	Decreases Expression	[12]
Stanniocalcin-2 (STC2)	OT86YP8G	STC2_HUMAN	Decreases Expression	[12]
Kelch-like protein 18 (KLHL18)	OTX7NOSM	KLH18_HUMAN	Increases Expression	[12]
RCC1 and BTB domain-containing protein 2 (RCBTB2)	OTECBF4R	RCBT2_HUMAN	Decreases Expression	[12]
ATP-binding cassette sub-family C member 6 (ABCC6)	OTZT0LKT	MRP6_HUMAN	Decreases Expression	[12]
Coagulation factor XIII A chain (F13A1)	OTO8O184	F13A_HUMAN	Increases Expression	[12]
Coagulation factor X (F10)	OT2BLK17	FA10_HUMAN	Decreases Expression	[12]
Plasminogen (PLG)	OTWWIPPY	PLMN_HUMAN	Decreases Expression	[12]
Alpha-1-antitrypsin (SERPINA1)	OTACYW9J	A1AT_HUMAN	Decreases Expression	[12]
HLA class I histocompatibility antigen, B alpha chain (HLA-B)	OTNXFWY2	HLAB_HUMAN	Increases Expression	[12]
Hemoglobin subunit epsilon (HBE1)	OTJPKMX4	HBE_HUMAN	Decreases Expression	[12]
Apolipoprotein C-I (APOC1)	OTA58CED	APOC1_HUMAN	Decreases Expression	[12]
Hemopexin (HPX)	OT14T7Q1	HEMO_HUMAN	Decreases Expression	[12]
Platelet-derived growth factor subunit A (PDGFA)	OTCMZ0W8	PDGFA_HUMAN	Decreases Expression	[12]
Trefoil factor 1 (TFF1)	OTCYQH4F	TFF1_HUMAN	Decreases Expression	[12]
Fructose-bisphosphate aldolase B (ALDOB)	OT7FR69A	ALDOB_HUMAN	Decreases Expression	[12]
Thyroxine-binding globulin (SERPINA7)	OTUYVTSU	THBG_HUMAN	Decreases Expression	[12]
Fatty acid-binding protein, liver (FABP1)	OTR34ETM	FABPL_HUMAN	Decreases Expression	[12]
Asialoglycoprotein receptor 1 (ASGR1)	OTS99MJO	ASGR1_HUMAN	Decreases Expression	[12]
Asparagine synthetase (ASNS)	OT8R922G	ASNS_HUMAN	Decreases Expression	[12]
Homeobox protein Hox-D4 (HOXD4)	OTQR4WCG	HXD4_HUMAN	Increases Expression	[12]
Annexin A4 (ANXA4)	OTUCRYXL	ANXA4_HUMAN	Decreases Expression	[12]
Cystic fibrosis transmembrane conductance regulator (CFTR)	OT6B22QH	CFTR_HUMAN	Decreases Expression	[12]
Tartrate-resistant acid phosphatase type 5 (ACP5)	OTBV4498	PPA5_HUMAN	Decreases Expression	[12]
Folate receptor alpha (FOLR1)	OT0QZ0H6	FOLR1_HUMAN	Decreases Expression	[12]
Integrin alpha-2 (ITGA2)	OTPFL017	ITA2_HUMAN	Increases Expression	[12]
HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1)	OT7OG7Y2	DPA1_HUMAN	Decreases Expression	[12]
Aromatic-L-amino-acid decarboxylase (DDC)	OT0TSW09	DDC_HUMAN	Decreases Expression	[12]
Carbonic anhydrase 4 (CA4)	OT3K93LZ	CAH4_HUMAN	Decreases Expression	[12]
Sodium-dependent noradrenaline transporter (SLC6A2)	OTMHQJMP	SC6A2_HUMAN	Increases Expression	[12]
Interleukin-4 receptor subunit alpha (IL4R)	OTTXOTCW	IL4RA_HUMAN	Decreases Expression	[12]
Atypical chemokine receptor 3 (ACKR3)	OTA6GA4F	ACKR3_HUMAN	Increases Expression	[12]
Integrin alpha-3 (ITGA3)	OTBCH21D	ITA3_HUMAN	Decreases Expression	[12]
Tyrosine-protein phosphatase non-receptor type 3 (PTPN3)	OTSLZBVY	PTN3_HUMAN	Decreases Expression	[12]
Leukocyte elastase inhibitor (SERPINB1)	OT5RDUFO	ILEU_HUMAN	Decreases Expression	[12]
Homeobox protein Hox-D3 (HOXD3)	OTBUZ35T	HXD3_HUMAN	Increases Expression	[12]
Fibrillin-1 (FBN1)	OTYCJT63	FBN1_HUMAN	Decreases Expression	[12]
Glutamate receptor ionotropic, kainate 1 (GRIK1)	OTO19X5C	GRIK1_HUMAN	Increases Expression	[12]
Pre-B-cell leukemia transcription factor 2 (PBX2)	OTEBYCAW	PBX2_HUMAN	Decreases Expression	[12]
ETS translocation variant 5 (ETV5)	OTE2OBM4	ETV5_HUMAN	Decreases Expression	[12]
Mitogen-activated protein kinase kinase kinase 8 (MAP3K8)	OTOZTA1F	M3K8_HUMAN	Increases Expression	[12]
Glutamate receptor 3 (GRIA3)	OT34CNBR	GRIA3_HUMAN	Increases Expression	[12]
Cathepsin O (CTSO)	OTFL6VRO	CATO_HUMAN	Decreases Expression	[12]
Cathepsin K (CTSK)	OTT3YX5O	CATK_HUMAN	Decreases Expression	[12]
G protein-coupled receptor kinase 6 (GRK6)	OT4LZTP9	GRK6_HUMAN	Decreases Expression	[12]
Stromal cell-derived factor 1 (CXCL12)	OT2QX5LL	SDF1_HUMAN	Decreases Expression	[12]
Flavin-containing monooxygenase 5 (FMO5)	OTTILF8T	FMO5_HUMAN	Decreases Expression	[12]
Inositol polyphosphate 1-phosphatase (INPP1)	OTHSJCRQ	INPP_HUMAN	Decreases Expression	[12]
Retinoic acid receptor responder protein 1 (RARRES1)	OTETUPP5	TIG1_HUMAN	Decreases Expression	[12]
Type I iodothyronine deiodinase (DIO1)	OTFYLYJ0	IOD1_HUMAN	Decreases Expression	[12]
5-formyltetrahydrofolate cyclo-ligase (MTHFS)	OTZ39JNR	MTHFS_HUMAN	Decreases Expression	[12]
Arylsulfatase D (ARSD)	OTAHW9M8	ARSD_HUMAN	Decreases Expression	[12]
G-protein coupled receptor 143 (GPR143)	OTWUA2AV	GP143_HUMAN	Decreases Expression	[12]
Pancreatic lipase-related protein 2 (PNLIPRP2)	OTJG6BA7	LIPR2_HUMAN	Decreases Expression	[12]
Tyrosine-protein phosphatase non-receptor type 5 (PTPN5)	OT2H1KDK	PTN5_HUMAN	Decreases Expression	[12]
Proteinase-activated receptor 2 (F2RL1)	OTMRMJ8N	PAR2_HUMAN	Decreases Expression	[12]
Hormonally up-regulated neu tumor-associated kinase (HUNK)	OTZR4GBH	HUNK_HUMAN	Decreases Expression	[12]
F-box/WD repeat-containing protein 4 (FBXW4)	OTEGSZOX	FBXW4_HUMAN	Decreases Expression	[12]
Clarin-1 (CLRN1)	OT1ADI7Q	CLRN1_HUMAN	Increases Expression	[12]
Beta-defensin 1 (DEFB1)	OT5SV0E4	DEFB1_HUMAN	Decreases Expression	[12]
DDB1- and CUL4-associated factor 7 (DCAF7)	OT3W5DYL	DCAF7_HUMAN	Increases Expression	[12]
Inward rectifier potassium channel 2 (KCNJ2)	OT2OQEZS	KCNJ2_HUMAN	Decreases Expression	[12]
POU domain, class 6, transcription factor 2 (POU6F2)	OTNSW95F	PO6F2_HUMAN	Increases Expression	[12]
Protein crumbs homolog 1 (CRB1)	OTXYUNG0	CRUM1_HUMAN	Increases Expression	[12]
Fibulin-2 (FBLN2)	OTEHR7N7	FBLN2_HUMAN	Decreases Expression	[12]
Cyclin-dependent kinase 3 (CDK3)	OT2GP6RL	CDK3_HUMAN	Decreases Expression	[12]
AMP deaminase 3 (AMPD3)	OT5SP1KJ	AMPD3_HUMAN	Decreases Expression	[12]
Trefoil factor 2 (TFF2)	OTRXB19X	TFF2_HUMAN	Decreases Expression	[12]
1,4-alpha-glucan-branching enzyme (GBE1)	OTK2N05B	GLGB_HUMAN	Decreases Expression	[12]
Aldehyde oxidase (AOX1)	OT2FZP6H	AOXA_HUMAN	Decreases Expression	[12]
Sulfotransferase 2A1 (SULT2A1)	OT0ISKQ4	ST2A1_HUMAN	Decreases Expression	[12]
Filensin (BFSP1)	OTXZ3YIU	BFSP1_HUMAN	Decreases Expression	[12]
Semaphorin-3B (SEMA3B)	OTCZCPMS	SEM3B_HUMAN	Decreases Expression	[12]
Semaphorin-3F (SEMA3F)	OTQFMS8S	SEM3F_HUMAN	Decreases Expression	[12]
Caprin-1 (CAPRIN1)	OTEJAMS3	CAPR1_HUMAN	Decreases Expression	[12]
Sarcospan (SSPN)	OTYG2SL7	SSPN_HUMAN	Decreases Expression	[12]
Cytohesin-1 (CYTH1)	OTYH9NRJ	CYH1_HUMAN	Decreases Expression	[12]
NT-3 growth factor receptor (NTRK3)	OTII30MY	NTRK3_HUMAN	Increases Expression	[12]
Melanoma antigen recognized by T-cells 1 (MLANA)	OT1N2S2K	MAR1_HUMAN	Decreases Expression	[12]
Interphotoreceptor matrix proteoglycan 1 (IMPG1)	OT12HBL0	IMPG1_HUMAN	Increases Expression	[12]
Protein Shroom1 (SHROOM1)	OTUP99ZD	SHRM1_HUMAN	Decreases Expression	[12]
Transmembrane protein 44 (TMEM44)	OTRUF467	TMM44_HUMAN	Decreases Expression	[12]
Hexokinase HKDC1 (HKDC1)	OTTHDMBM	HKDC1_HUMAN	Decreases Expression	[12]
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2 (ITPRIPL2)	OTSSP13W	IPIL2_HUMAN	Decreases Expression	[12]
Membrane protein FAM174B (FAM174B)	OT1SCOTY	F174B_HUMAN	Decreases Expression	[12]
OCIA domain-containing protein 2 (OCIAD2)	OTSWB4SZ	OCAD2_HUMAN	Decreases Expression	[12]
UMP-CMP kinase 2, mitochondrial (CMPK2)	OTOG90R0	CMPK2_HUMAN	Decreases Expression	[12]
FRAS1-related extracellular matrix protein 1 (FREM1)	OTMHRV87	FREM1_HUMAN	Decreases Expression	[12]
Calcium homeostasis modulator protein 6 (CALHM6)	OTLX9B4Y	CAHM6_HUMAN	Decreases Expression	[12]
Putative hydroxypyruvate isomerase (HYI)	OTFPNOTN	HYI_HUMAN	Decreases Expression	[12]
Probable gluconokinase (IDNK)	OT5ZC54L	GNTK_HUMAN	Decreases Expression	[12]
Dynein regulatory complex protein 8 (EFCAB2)	OTXEFI4O	DRC8_HUMAN	Decreases Expression	[12]
Little elongation complex subunit 2 (ICE2)	OTJ3BXND	ICE2_HUMAN	Increases Expression	[12]
Polypeptide N-acetylgalactosaminyltransferase 17 (GALNT17)	OTMF0W2U	GLT17_HUMAN	Decreases Expression	[12]
Serine/threonine-protein phosphatase 4 regulatory subunit 4 (PPP4R4)	OTKZDDIF	PP4R4_HUMAN	Increases Expression	[12]
Transmembrane protein 220 (TMEM220)	OTGTRDNX	TM220_HUMAN	Decreases Expression	[12]
Sushi domain-containing protein 1 (SUSD1)	OTR3UGLY	SUSD1_HUMAN	Decreases Expression	[12]
Thiol S-methyltransferase TMT1B (TMT1B)	OTP0QOAL	TMT1B_HUMAN	Decreases Expression	[12]
Gliomedin (GLDN)	OTA8TQU9	GLDN_HUMAN	Increases Expression	[12]
Refilin-A (RFLNA)	OT6GS3XQ	RFLA_HUMAN	Decreases Expression	[12]
Protein CFAP20DC (CFAP20DC)	OTVOREMP	CF20D_HUMAN	Increases Expression	[12]
Fibrillin-3 (FBN3)	OTEWLXTH	FBN3_HUMAN	Decreases Expression	[12]
Cytoplasmic FMR1-interacting protein 1 (CYFIP1)	OTOBEH24	CYFP1_HUMAN	Decreases Expression	[12]
Carbohydrate sulfotransferase 15 (CHST15)	OTNTM2SP	CHSTF_HUMAN	Increases Expression	[12]
Neuronal growth regulator 1 (NEGR1)	OT57ECW9	NEGR1_HUMAN	Increases Expression	[12]
Microtubule organization protein AKNA (AKNA)	OTQ6E2C8	AKNA_HUMAN	Decreases Expression	[12]
E3 ubiquitin-protein ligase RNF180 (RNF180)	OT2GKIKE	RN180_HUMAN	Decreases Expression	[12]
Hyaluronan and proteoglycan link protein 4 (HAPLN4)	OTZQOG9A	HPLN4_HUMAN	Decreases Expression	[12]
Proline-rich membrane anchor 1 (PRIMA1)	OT9ITT3P	PRIMA_HUMAN	Decreases Expression	[12]
Enoyl-CoA hydratase domain-containing protein 2, mitochondrial (ECHDC2)	OTL0DWCO	ECHD2_HUMAN	Decreases Expression	[12]
L-seryl-tRNA(Sec) kinase (PSTK)	OTA5UXAX	PSTK_HUMAN	Decreases Expression	[12]
Protein mono-ADP-ribosyltransferase PARP9 (PARP9)	OT7K4494	PARP9_HUMAN	Decreases Expression	[12]
Solute carrier family 35 member F3 (SLC35F3)	OTAOBKBG	S35F3_HUMAN	Decreases Expression	[12]
Ribonuclease SLFN12 (SLFN12)	OTTBXM25	SLN12_HUMAN	Increases Expression	[12]
UPF0462 protein C4orf33 (C4ORF33)	OT3O3FC3	CD033_HUMAN	Increases Expression	[12]
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (PYROXD2)	OTJIX22S	PYRD2_HUMAN	Decreases Expression	[12]
T-cell activation inhibitor, mitochondrial (TCAIM)	OTOBD7YO	TCAIM_HUMAN	Decreases Expression	[12]
Choline transporter-like protein 3 (SLC44A3)	OTL0FT8L	CTL3_HUMAN	Decreases Expression	[12]
Dynein light chain Tctex-type 5 (DYNLT5)	OTDM1DWJ	DYLT5_HUMAN	Increases Expression	[12]
Proprotein convertase subtilisin/kexin type 9 (PCSK9)	OTI0DU9Y	PCSK9_HUMAN	Decreases Expression	[12]
Clarin-3 (CLRN3)	OTZDNL65	CLRN3_HUMAN	Decreases Expression	[12]
Putative methyltransferase NSUN7 (NSUN7)	OTDTL9UE	NSUN7_HUMAN	Decreases Expression	[12]
Phospholipid phosphatase 5 (PLPP5)	OTHT51D6	PLPP5_HUMAN	Decreases Expression	[12]
Interleukin-17D (IL17D)	OTMBLLRF	IL17D_HUMAN	Decreases Expression	[12]
E3 ubiquitin-protein ligase DTX3L (DTX3L)	OTCCO2QZ	DTX3L_HUMAN	Decreases Expression	[12]
CDK5 and ABL1 enzyme substrate 1 (CABLES1)	OTMN4XSX	CABL1_HUMAN	Decreases Expression	[12]
Serine/threonine-protein kinase 32A (STK32A)	OTONYLYO	ST32A_HUMAN	Decreases Expression	[12]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (ARAP3)	OTUWZTH7	ARAP3_HUMAN	Decreases Expression	[12]
Nanos homolog 1 (NANOS1)	OT3UNZZY	NANO1_HUMAN	Decreases Expression	[12]
Lysophosphatidic acid receptor 1 (LPAR1)	OTJNJQPF	LPAR1_HUMAN	Decreases Expression	[12]
Histone-lysine N-methyltransferase EZH1 (EZH1)	OTFLUU94	EZH1_HUMAN	Increases Expression	[12]
Peroxisomal membrane protein PEX13 (PEX13)	OTXUAYEW	PEX13_HUMAN	Increases Expression	[12]
Homogentisate 1,2-dioxygenase (HGD)	OTTKLQOO	HGD_HUMAN	Decreases Expression	[12]
Collagen alpha-1(XXVI) chain (COL26A1)	OTMS7RNF	COQA1_HUMAN	Decreases Expression	[12]
Dedicator of cytokinesis protein 10 (DOCK10)	OTI3MBLV	DOC10_HUMAN	Decreases Expression	[12]
Copine-2 (CPNE2)	OTPESEM5	CPNE2_HUMAN	Decreases Expression	[12]
Coiled-coil domain-containing protein 34 (CCDC34)	OTZ3AGSQ	CCD34_HUMAN	Increases Expression	[12]
Fatty acyl-CoA reductase 2 (FAR2)	OTRYY709	FACR2_HUMAN	Decreases Expression	[12]
Adenylate kinase 7 (AK7)	OTASZDJN	KAD7_HUMAN	Increases Expression	[12]
Sodium channel and clathrin linker 1 (SCLT1)	OT2ZSSP4	SCLT1_HUMAN	Increases Expression	[12]
Erythroid membrane-associated protein (ERMAP)	OTKXBB52	ERMAP_HUMAN	Decreases Expression	[12]
Tribbles homolog 3 (TRIB3)	OTG5OS7X	TRIB3_HUMAN	Decreases Expression	[12]
Glutathione peroxidase 7 (GPX7)	OTINT9Z4	GPX7_HUMAN	Decreases Expression	[12]
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5)	OTQR6ENW	M3K5_HUMAN	Decreases Expression	[12]
Melanin-concentrating hormone receptor 1 (MCHR1)	OTT57EOE	MCHR1_HUMAN	Decreases Expression	[12]
Dual specificity protein phosphatase 9 (DUSP9)	OTZZWEQL	DUS9_HUMAN	Decreases Expression	[12]
NAD-capped RNA hydrolase NUDT12 (NUDT12)	OTBUY58C	NUD12_HUMAN	Increases Expression	[12]
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21)	OTB78IF4	ODC_HUMAN	Decreases Expression	[12]
MARVEL domain-containing protein 1 (MARVELD1)	OT5CPOJE	MALD1_HUMAN	Decreases Expression	[12]
Spexin (SPX)	OTY3G4AR	SPXN_HUMAN	Decreases Expression	[12]
Acireductone dioxygenase (ADI1)	OT8IOD03	MTND_HUMAN	Decreases Expression	[12]
Caspase recruitment domain-containing protein 10 (CARD10)	OT2RPM4I	CAR10_HUMAN	Decreases Expression	[12]
Contactin-associated protein-like 4 (CNTNAP4)	OTKXR9AW	CNTP4_HUMAN	Decreases Expression	[12]
Glycosyltransferase 8 domain-containing protein 2 (GLT8D2)	OT4VS9YY	GL8D2_HUMAN	Decreases Expression	[12]
Cytosolic beta-glucosidase (GBA3)	OT86XWU2	GBA3_HUMAN	Decreases Expression	[12]
Lysine-specific demethylase 4C (KDM4C)	OT2RHV9S	KDM4C_HUMAN	Increases Expression	[12]
NIPA-like protein 2 (NIPAL2)	OTX9UREP	NPAL2_HUMAN	Decreases Expression	[12]
Sialate O-acetylesterase (SIAE)	OTDQUESH	SIAE_HUMAN	Increases Expression	[12]
Pleckstrin homology domain-containing family A member 2 (PLEKHA2)	OTY2AP6T	PKHA2_HUMAN	Decreases Expression	[12]
Beta-parvin (PARVB)	OT9OGVWX	PARVB_HUMAN	Decreases Expression	[12]
3',5'-cyclic-AMP phosphodiesterase 7B (PDE7B)	OTK3SHT2	PDE7B_HUMAN	Increases Expression	[12]
Cell death regulator Aven (AVEN)	OTGIN5YK	AVEN_HUMAN	Decreases Expression	[12]
Rho guanine nucleotide exchange factor 4 (ARHGEF4)	OTR2VG0W	ARHG4_HUMAN	Decreases Expression	[12]
Interleukin-17 receptor B (IL17RB)	OT0KDNSF	I17RB_HUMAN	Decreases Expression	[12]
Probable G-protein coupled receptor 27 (GPR27)	OTH4KQPI	GPR27_HUMAN	Decreases Expression	[12]
Transmembrane protein 51 (TMEM51)	OTZCW8XJ	TMM51_HUMAN	Decreases Expression	[12]
24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1)	OTBAJT4I	CP39A_HUMAN	Increases Expression	[12]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1)	OTJISZOX	PLCE1_HUMAN	Decreases Expression	[12]
Doublecortin domain-containing protein 2 (DCDC2)	OTSUFH1H	DCDC2_HUMAN	Decreases Expression	[12]
Cadherin-9 (CDH9)	OTV9N5XK	CADH9_HUMAN	Decreases Expression	[12]
Long-chain-fatty-acid--CoA ligase 5 (ACSL5)	OT3L9XO3	ACSL5_HUMAN	Decreases Expression	[12]
Mammalian ependymin-related protein 1 (EPDR1)	OT5JW5RB	EPDR1_HUMAN	Decreases Expression	[12]
Cystine/glutamate transporter (SLC7A11)	OTKJ6PXW	XCT_HUMAN	Decreases Expression	[12]
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 (FUT9)	OTLIJBQY	FUT9_HUMAN	Increases Expression	[12]
Sorting nexin-10 (SNX10)	OT05B7BT	SNX10_HUMAN	Decreases Expression	[12]
CCN family member 1 (CCN1)	OTKJBEMD	CCN1_HUMAN	Increases Expression	[13]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Increases Expression	[16]
Insulin-like growth factor I (IGF1)	OTIIZR61	IGF1_HUMAN	Increases Expression	[13]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Expression	[13]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[16]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[13]
Nuclear factor NF-kappa-B p105 subunit (NFKB1)	OTNRRD8I	NFKB1_HUMAN	Increases Expression	[16]
NF-kappa-B inhibitor alpha (NFKBIA)	OTFT924M	IKBA_HUMAN	Increases Expression	[16]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Increases Phosphorylation	[13]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Cleavage	[16]
Glycogen synthase kinase-3 beta (GSK3B)	OTL3L14B	GSK3B_HUMAN	Increases Phosphorylation	[13]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Increases Cleavage	[17]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Cleavage	[16]
Transforming growth factor beta-2 proprotein (TGFB2)	OTC0TXEP	TGFB2_HUMAN	Increases Expression	[13]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Increases Acetylation	[16]

Indication(s) of Gemcitabine

Disease Entry	ICD 11	Status	REF
Anterior urethra cancer	N.A.	Approved	[5]
Biliary tract cancer	2C17	Approved	[5]
Carcinoma	2A00-2F9Z	Approved	[5]
Cervical cancer	2C77.0	Approved	[5]
Cholangiocarcinoma	2C12.10	Approved	[5]
Fallopian tube neoplasm	N.A.	Approved	[5]
Gallbladder carcinoma	N.A.	Approved	[5]
Leiomyosarcoma	2B58	Approved	[5]
Leukemia	N.A.	Approved	[5]
Lung cancer	2C25.0	Approved	[5]
MALT lymphoma	N.A.	Approved	[5]
Nodal marginal zone lymphoma	2A85.0	Approved	[5]
Non-small-cell lung cancer	2C25	Approved	[6]
Ovarian disorder	N.A.	Approved	[5]
Ovarian neoplasm	N.A.	Approved	[5]
Pancreatic adenocarcinoma	N.A.	Approved	[5]
Pancreatic ductal carcinoma	2C10.0	Approved	[5]
Pancreatic tumour	2C10	Approved	[5]
Posterior urethra cancer	N.A.	Approved	[5]
Recurrent adult burkitt lymphoma	2A85.6	Approved	[5]
Solid tumour/cancer	2A00-2F9Z	Approved	[7]
Splenic marginal zone lymphoma	N.A.	Approved	[5]
Urethral cancer	2C93	Approved	[5]
Urinary bladder neoplasm	N.A.	Approved	[5]
Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[8]
Severe acute respiratory syndrome (SARS)	1D65	Preclinical	[8]
Colon cancer	2B90.Z	Investigative	[5]

Gemcitabine Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Ribonucleoside-diphosphate reductase M2 (RRM2)	TTBWDI0	RIR2_HUMAN	Modulator	[24]

Gemcitabine Interacts with 3 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[25]
Multidrug resistance-associated protein 5 (ABCC5)	DTYVM24	MRP5_HUMAN	Substrate	[26]
Concentrative nucleoside transporter 1 (SLC28A1)	DT0EQPW	S28A1_HUMAN	Substrate	[27]

Gemcitabine Interacts with 5 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytidine aminohydrolase (CDA)	DEKEDRC	CDD_HUMAN	Metabolism	[28]
Uridine/cytidine monophosphate kinase (UMPK)	DEMPH4I	KCY_HUMAN	Metabolism	[29]
Cytidine deaminase (cdd)	DETX3A5	CDD_ECOLI	Metabolism	[30]
Cytidine deaminase (cdd)	DEFVABT	CDD_KLEP7	Metabolism	[30]
Cytidine deaminase (cdd)	DEYILK4	E0TLJ6_MYCHH	Metabolism	[31]

Gemcitabine Interacts with 244 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytidine deaminase (CDA)	OT3HXP6N	CDD_HUMAN	Affects Response To Substance	[22]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Decreases Expression	[32]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2)	OTOB6J6R	RIR2_HUMAN	Affects Response To Substance	[23]
Ribonucleoside-diphosphate reductase large subunit (RRM1)	OTXGQOR9	RIR1_HUMAN	Affects Response To Substance	[23]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Increases Expression	[33]
Epidermal growth factor receptor (EGFR)	OTAPLO1S	EGFR_HUMAN	Decreases Expression	[34]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[35]
NF-kappa-B inhibitor epsilon (NFKBIE)	OTLAYEL9	IKBE_HUMAN	Affects Expression	[18]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)	OTQ4W7MT	TR11B_HUMAN	Increases Expression	[18]
Stearoyl-CoA desaturase (SCD)	OTB1073G	SCD_HUMAN	Increases Expression	[18]
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)	OT5I4Y9K	PLCB_HUMAN	Decreases Expression	[18]
Insulin-induced gene 1 protein (INSIG1)	OTZF5X1D	INSI1_HUMAN	Increases Expression	[18]
E3 ubiquitin-protein ligase Praja-2 (PJA2)	OT45TMC4	PJA2_HUMAN	Increases Expression	[18]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2)	OT6Y1QZN	IRAK2_HUMAN	Increases Expression	[18]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Increases Expression	[18]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L)	OTJKOMXE	BNI3L_HUMAN	Increases Expression	[18]
Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP)	OTRNDZXB	HNRPQ_HUMAN	Decreases Expression	[18]
Melanoma-associated antigen C1 (MAGEC1)	OTHMFHH8	MAGC1_HUMAN	Increases Expression	[18]
Liprin-alpha-4 (PPFIA4)	OTWXG0DO	LIPA4_HUMAN	Increases Expression	[18]
Transcription factor Maf (MAF)	OT1GR3IZ	MAF_HUMAN	Increases Expression	[18]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)	OTYG179K	PR15A_HUMAN	Increases Expression	[18]
Krueppel-like factor 8 (KLF8)	OTUC5CDB	KLF8_HUMAN	Increases Expression	[18]
Urokinase-type plasminogen activator (PLAU)	OTX0QGKK	UROK_HUMAN	Increases Expression	[18]
Fibrinogen gamma chain (FGG)	OT5BJSEX	FIBG_HUMAN	Affects Expression	[18]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Expression	[18]
Keratin, type II cytoskeletal 8 (KRT8)	OTTM4X11	K2C8_HUMAN	Decreases Expression	[18]
Growth-regulated alpha protein (CXCL1)	OT3WCTZV	GROA_HUMAN	Increases Expression	[18]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)	OTXOQDSG	IFIT1_HUMAN	Increases Expression	[18]
Transcriptional activator Myb (MYB)	OTJH64IV	MYB_HUMAN	Increases Expression	[18]
Osteopontin (SPP1)	OTJGC23Y	OSTP_HUMAN	Increases Expression	[18]
Endoplasmic reticulum chaperone BiP (HSPA5)	OTFUIRAO	BIP_HUMAN	Increases Expression	[18]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)	OT2HZK5M	GTR3_HUMAN	Increases Expression	[18]
Creatine kinase B-type (CKB)	OTUCKOTT	KCRB_HUMAN	Decreases Expression	[18]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Increases Expression	[18]
Homeobox protein Hox-B2 (HOXB2)	OTTD6HMV	HXB2_HUMAN	Increases Expression	[18]
Fos-related antigen 2 (FOSL2)	OT3MT9HJ	FOSL2_HUMAN	Decreases Expression	[18]
Methylated-DNA--protein-cysteine methyltransferase (MGMT)	OT40A9WH	MGMT_HUMAN	Decreases Expression	[18]
CCAAT/enhancer-binding protein beta (CEBPB)	OTM9MQIA	CEBPB_HUMAN	Increases Expression	[18]
Early growth response protein 1 (EGR1)	OTCP6XGZ	EGR1_HUMAN	Increases Expression	[18]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3)	OTC1UOHP	ATF3_HUMAN	Increases Expression	[18]
C-X-C motif chemokine 2 (CXCL2)	OTEJCYMY	CXCL2_HUMAN	Increases Expression	[18]
C-X-C motif chemokine 3 (CXCL3)	OTSL94KH	CXCL3_HUMAN	Increases Expression	[18]
Endothelin-2 (EDN2)	OTQ7RCPI	EDN2_HUMAN	Decreases Expression	[18]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)	OTVLI4DD	TNAP3_HUMAN	Increases Expression	[18]
Diamine acetyltransferase 1 (SAT1)	OT52AU22	SAT1_HUMAN	Increases Expression	[18]
Prostaglandin G/H synthase 1 (PTGS1)	OTHCRLEC	PGH1_HUMAN	Decreases Expression	[18]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Decreases Expression	[18]
Tumor necrosis factor receptor superfamily member 5 (CD40)	OT5YU2XB	TNR5_HUMAN	Decreases Expression	[18]
Myristoylated alanine-rich C-kinase substrate (MARCKS)	OT7N056G	MARCS_HUMAN	Increases Expression	[18]
Protein EVI2B (EVI2B)	OT98X1OE	EVI2B_HUMAN	Decreases Expression	[18]
Heat shock 70 kDa protein 1-like (HSPA1L)	OTC2V1K6	HS71L_HUMAN	Decreases Expression	[18]
Glutaredoxin-1 (GLRX)	OT0QHTAR	GLRX1_HUMAN	Increases Expression	[18]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[18]
Nicotinamide N-methyltransferase (NNMT)	OTFM38GU	NNMT_HUMAN	Increases Expression	[18]
B-cell lymphoma 6 protein (BCL6)	OTQAWWO1	BCL6_HUMAN	Increases Expression	[18]
Regulator of G-protein signaling 2 (RGS2)	OT0FSRW7	RGS2_HUMAN	Increases Expression	[18]
Leukemia inhibitory factor receptor (LIFR)	OT36W9O5	LIFR_HUMAN	Increases Expression	[18]
Melanoma-associated antigen 10 (MAGEA10)	OTI4KPYB	MAGAA_HUMAN	Decreases Expression	[18]
Lysophosphatidic acid receptor 6 (LPAR6)	OT4BY3W4	LPAR6_HUMAN	Decreases Expression	[18]
Ras GTPase-activating-like protein IQGAP1 (IQGAP1)	OTZRWTGA	IQGA1_HUMAN	Increases Expression	[18]
Retinaldehyde dehydrogenase 3 (ALDH1A3)	OT1C9NKQ	AL1A3_HUMAN	Increases Expression	[18]
Max-interacting protein 1 (MXI1)	OTUQ9E0D	MXI1_HUMAN	Increases Expression	[18]
ETS translocation variant 1 (ETV1)	OT6PMJIK	ETV1_HUMAN	Increases Expression	[18]
Glypican-3 (GPC3)	OTWS8WSW	GPC3_HUMAN	Increases Expression	[18]
Transcription initiation factor IIA subunit 1 (GTF2A1)	OTWW4PN0	TF2AA_HUMAN	Affects Expression	[18]
Growth arrest-specific protein 1 (GAS1)	OTKJXG52	GAS1_HUMAN	Decreases Expression	[18]
Puromycin-sensitive aminopeptidase (NPEPPS)	OTMENFXR	PSA_HUMAN	Decreases Expression	[18]
Methionine--tRNA ligase, cytoplasmic (MARS1)	OTLJ6MHJ	SYMC_HUMAN	Increases Expression	[18]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)	OTOWDUNT	PTEN_HUMAN	Affects Expression	[18]
Ras-related protein Rab-8A (RAB8A)	OTPB54Y3	RAB8A_HUMAN	Decreases Expression	[18]
Lysozyme C (LYZ)	OTD7H0G6	LYSC_HUMAN	Decreases Expression	[18]
Transforming growth factor beta-2 proprotein (TGFB2)	OTC0TXEP	TGFB2_HUMAN	Increases Expression	[18]
Large ribosomal subunit protein eL37 (RPL37)	OTB6SDZ1	RL37_HUMAN	Increases Expression	[18]
Histone H4 (H4C1)	OTB71W46	H4_HUMAN	Decreases Expression	[18]
C-C motif chemokine 20 (CCL20)	OTUCJY4N	CCL20_HUMAN	Increases Expression	[18]
ADP-ribosylation factor 1 (ARF1)	OT5C4C3L	ARF1_HUMAN	Decreases Expression	[18]
Nuclear factor NF-kappa-B p100 subunit (NFKB2)	OTS231V7	NFKB2_HUMAN	Affects Expression	[18]
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase , mitochondrial (ALDH6A1)	OT8LCZCT	MMSA_HUMAN	Increases Expression	[18]
Pro-neuregulin-1, membrane-bound isoform (NRG1)	OTZO6F1X	NRG1_HUMAN	Increases Expression	[18]
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)	OTFH9M73	PTN11_HUMAN	Affects Expression	[18]
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)	OTG2T749	CP24A_HUMAN	Decreases Expression	[18]
ATP-dependent RNA helicase A (DHX9)	OT5AAOQI	DHX9_HUMAN	Decreases Expression	[18]
Nuclear cap-binding protein subunit 1 (NCBP1)	OTYBR927	NCBP1_HUMAN	Increases Expression	[18]
TP53-binding protein 1 (TP53BP1)	OTL8879S	TP53B_HUMAN	Increases Expression	[18]
Ankyrin-3 (ANK3)	OTJ3IRBP	ANK3_HUMAN	Increases Expression	[18]
TNF receptor-associated factor 1 (TRAF1)	OTTLM5RU	TRAF1_HUMAN	Affects Expression	[18]
PDZK1-interacting protein 1 (PDZK1IP1)	OTWA6M5K	PDZ1I_HUMAN	Increases Expression	[18]
Treacle protein (TCOF1)	OT4BOYTM	TCOF_HUMAN	Decreases Expression	[18]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Affects Expression	[18]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Increases Expression	[18]
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1)	OTD1KRKO	DYHC1_HUMAN	Decreases Expression	[18]
Enhancer of filamentation 1 (NEDD9)	OTGCFN4M	CASL_HUMAN	Increases Expression	[18]
Interferon regulatory factor 3 (IRF3)	OT81U8ME	IRF3_HUMAN	Decreases Expression	[18]
FXYD domain-containing ion transport regulator 3 (FXYD3)	OT9PPRHE	FXYD3_HUMAN	Increases Expression	[18]
Ankyrin repeat domain-containing protein 1 (ANKRD1)	OTHJ7JV9	ANKR1_HUMAN	Increases Expression	[18]
Disks large homolog 2 (DLG2)	OTQ3BD8U	DLG2_HUMAN	Increases Expression	[18]
Cysteine and glycine-rich protein 2 (CSRP2)	OT4SW0HI	CSRP2_HUMAN	Increases Expression	[18]
Cyclin-G2 (CCNG2)	OTII38K2	CCNG2_HUMAN	Increases Expression	[18]
Golgi-associated kinase 1B (GASK1B)	OT2HPHEI	GAK1B_HUMAN	Decreases Expression	[18]
SUZ domain-containing protein 1 (SZRD1)	OTJMEJWT	SZRD1_HUMAN	Decreases Expression	[18]
Leucine-rich repeat-containing protein 28 (LRRC28)	OTFTT6VN	LRC28_HUMAN	Increases Expression	[18]
Mitochondrial basic amino acids transporter (SLC25A29)	OT09PIFE	S2529_HUMAN	Increases Expression	[18]
Equilibrative nucleobase transporter 1 (SLC43A3)	OTR60ZLA	S43A3_HUMAN	Decreases Expression	[18]
Proprotein convertase subtilisin/kexin type 9 (PCSK9)	OTI0DU9Y	PCSK9_HUMAN	Increases Expression	[18]
E3 ubiquitin-protein ligase RNF149 (RNF149)	OT6SBKQV	RN149_HUMAN	Increases Expression	[18]
F-box only protein 25 (FBXO25)	OTDFA7F4	FBX25_HUMAN	Increases Expression	[18]
Solute carrier family 2, facilitated glucose transporter member 14 (SLC2A14)	OTBFIOVY	GTR14_HUMAN	Increases Expression	[18]
Membrane progestin receptor beta (PAQR8)	OTGZ8W9F	PAQR8_HUMAN	Increases Expression	[18]
Nuclear receptor subfamily 4 group A member 3 (NR4A3)	OTPBE9R1	NR4A3_HUMAN	Increases Expression	[18]
La-related protein 4B (LARP4B)	OT2HI0QE	LAR4B_HUMAN	Increases Expression	[18]
Collagen triple helix repeat-containing protein 1 (CTHRC1)	OTV88X2G	CTHR1_HUMAN	Increases Expression	[18]
BTB/POZ domain-containing protein KCTD12 (KCTD12)	OTPYKT4Z	KCD12_HUMAN	Decreases Expression	[18]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1)	OTMV4ASV	MAGI1_HUMAN	Increases Expression	[18]
Sialidase-1 (NEU1)	OTH9BY8Y	NEUR1_HUMAN	Increases Expression	[18]
Galactosylceramide sulfotransferase (GAL3ST1)	OTSFFZRD	G3ST1_HUMAN	Decreases Expression	[18]
Junctional adhesion molecule C (JAM3)	OTX0F9QL	JAM3_HUMAN	Decreases Expression	[18]
SLIT and NTRK-like protein 2 (SLITRK2)	OTPVI22J	SLIK2_HUMAN	Increases Expression	[18]
Anaphase-promoting complex subunit 1 (ANAPC1)	OT2YY35L	APC1_HUMAN	Increases Expression	[18]
Anthrax toxin receptor 1 (ANTXR1)	OT5W1GPC	ANTR1_HUMAN	Affects Expression	[18]
Ras-related GTP-binding protein D (RRAGD)	OTXLVWAH	RRAGD_HUMAN	Increases Expression	[18]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Affects Expression	[18]
Intersectin-2 (ITSN2)	OT8S0OO8	ITSN2_HUMAN	Increases Expression	[18]
Probable ribosome biogenesis protein RLP24 (RSL24D1)	OT6KI56F	RLP24_HUMAN	Increases Expression	[18]
Transcription elongation factor A protein-like 9 (TCEAL9)	OT4UHDB5	TCAL9_HUMAN	Increases Expression	[18]
Histone deacetylase 9 (HDAC9)	OTO8O0LF	HDAC9_HUMAN	Increases Expression	[18]
Phosphoserine aminotransferase (PSAT1)	OTVV1YV9	SERC_HUMAN	Increases Expression	[18]
Chloride intracellular channel protein 4 (CLIC4)	OT6KTPKD	CLIC4_HUMAN	Increases Expression	[18]
Alpha-2-macroglobulin (A2M)	OTFTX90K	A2MG_HUMAN	Increases Expression	[19]
Pro-epidermal growth factor (EGF)	OTANRJ0L	EGF_HUMAN	Decreases Expression	[19]
Insulin (INS)	OTZ85PDU	INS_HUMAN	Increases Expression	[19]
Lymphotoxin-alpha (LTA)	OTUC3S76	TNFB_HUMAN	Increases Expression	[19]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Increases Expression	[19]
Interferon gamma (IFNG)	OTXG9JM7	IFNG_HUMAN	Decreases Expression	[19]
Interleukin-1 alpha (IL1A)	OTPSGILV	IL1A_HUMAN	Decreases Expression	[19]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Decreases Expression	[19]
Serum amyloid P-component (APCS)	OT76JZ8Z	SAMP_HUMAN	Decreases Expression	[19]
Beta-2-glycoprotein 1 (APOH)	OTFMUX6O	APOH_HUMAN	Increases Expression	[19]
Alpha-fetoprotein (AFP)	OT9GG3ZI	FETA_HUMAN	Decreases Expression	[19]
Granulocyte-macrophage colony-stimulating factor (CSF2)	OT1M7D28	CSF2_HUMAN	Decreases Expression	[19]
Interleukin-4 (IL4)	OTOXBWAU	IL4_HUMAN	Decreases Expression	[19]
Myeloperoxidase (MPO)	OTOOXLIN	PERM_HUMAN	Increases Expression	[19]
Endothelin-1 (EDN1)	OTZCACEG	EDN1_HUMAN	Decreases Expression	[19]
Intercellular adhesion molecule 1 (ICAM1)	OTTOIX77	ICAM1_HUMAN	Decreases Expression	[19]
Stromelysin-1 (MMP3)	OTGBI74Z	MMP3_HUMAN	Decreases Expression	[19]
Coagulation factor VII (F7)	OTGNJ97M	FA7_HUMAN	Decreases Expression	[19]
Fibroblast growth factor 2 (FGF2)	OT7YUJ9F	FGF2_HUMAN	Increases Expression	[19]
Granulocyte colony-stimulating factor (CSF3)	OT9GC6TP	CSF3_HUMAN	Decreases Expression	[19]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Decreases Expression	[19]
C-C motif chemokine 3 (CCL3)	OTW2H3ND	CCL3_HUMAN	Increases Expression	[19]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Decreases Expression	[19]
Prostatic acid phosphatase (ACP3)	OTSIM0YG	PPAP_HUMAN	Decreases Expression	[19]
Kit ligand (KITLG)	OTB9AVQ4	SCF_HUMAN	Decreases Expression	[19]
Interleukin-10 (IL10)	OTIRFRXC	IL10_HUMAN	Decreases Expression	[19]
Brain-derived neurotrophic factor (BDNF)	OTLGH7EW	BDNF_HUMAN	Decreases Expression	[19]
CD40 ligand (CD40LG)	OT75Z6A6	CD40L_HUMAN	Decreases Expression	[19]
Interleukin-13 (IL13)	OTI4YS3Y	IL13_HUMAN	Increases Expression	[19]
Thrombopoietin (THPO)	OTO73DZ2	TPO_HUMAN	Increases Expression	[19]
Interleukin-15 (IL15)	OTQSYWQS	IL15_HUMAN	Decreases Expression	[19]
Leptin (LEP)	OT5Q7ODW	LEP_HUMAN	Decreases Expression	[19]
Pappalysin-1 (PAPPA)	OTTTG9PG	PAPP1_HUMAN	Decreases Expression	[19]
Pro-interleukin-16 (IL16)	OTZ2MO6B	IL16_HUMAN	Increases Expression	[19]
Adiponectin (ADIPOQ)	OTNX23LE	ADIPO_HUMAN	Increases Expression	[19]
Aldehyde dehydrogenase 1A1 (ALDH1A1)	OTCUWZKB	AL1A1_HUMAN	Decreases Expression	[36]
Neurogenic locus notch homolog protein 1 (NOTCH1)	OTI1WADQ	NOTC1_HUMAN	Increases Expression	[36]
Proto-oncogene c-Rel (REL)	OTTCKMAC	REL_HUMAN	Decreases Expression	[36]
Telomerase reverse transcriptase (TERT)	OT085VVA	TERT_HUMAN	Decreases Activity	[37]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[38]
Nuclear protein 1 (NUPR1)	OT4FU8C0	NUPR1_HUMAN	Decreases Expression	[39]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Decreases Expression	[40]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Expression	[41]
Insulin-like growth factor 1 receptor (IGF1R)	OTXJIF13	IGF1R_HUMAN	Decreases Expression	[34]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Increases Expression	[42]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[43]
Zinc finger protein GLI2 (GLI2)	OTIRV97L	GLI2_HUMAN	Affects Expression	[34]
Clusterin (CLU)	OTQGG0JM	CLUS_HUMAN	Increases Expression	[44]
G2/mitotic-specific cyclin-B1 (CCNB1)	OT19S7E5	CCNB1_HUMAN	Decreases Expression	[34]
Serine/threonine-protein kinase B-raf (BRAF)	OT7S81XQ	BRAF_HUMAN	Decreases Expression	[34]
NAD(P)H dehydrogenase 1 (NQO1)	OTZGGIVK	NQO1_HUMAN	Increases Expression	[42]
CD44 antigen (CD44)	OT9TTJ41	CD44_HUMAN	Affects Expression	[32]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Expression	[45]
Insulin-like growth factor-binding protein 3 (IGFBP3)	OTIX63TX	IBP3_HUMAN	Affects Expression	[34]
Cannabinoid receptor 1 (CNR1)	OTEALO6G	CNR1_HUMAN	Increases Expression	[46]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Increases Expression	[47]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Increases Phosphorylation	[35]
Aryl hydrocarbon receptor nuclear translocator (ARNT)	OTMSIEZY	ARNT_HUMAN	Increases Expression	[34]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Increases Phosphorylation	[35]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Increases Methylation	[48]
Cannabinoid receptor 2 (CNR2)	OTYP9P43	CNR2_HUMAN	Increases Expression	[46]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Increases Expression	[49]
Breast cancer type 1 susceptibility protein (BRCA1)	OT5BN6VH	BRCA1_HUMAN	Increases Expression	[34]
Signal transducer and activator of transcription 3 (STAT3)	OTAAGKYZ	STAT3_HUMAN	Decreases Activity	[50]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[51]
Proliferation marker protein Ki-67 (MKI67)	OTA8N1QI	KI67_HUMAN	Decreases Expression	[38]
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)	OTI2OREX	MP2K3_HUMAN	Increases Phosphorylation	[52]
Transcription factor SOX-2 (SOX2)	OTFAWCAU	SOX2_HUMAN	Increases Expression	[49]
Glycogen synthase kinase-3 beta (GSK3B)	OTL3L14B	GSK3B_HUMAN	Increases Phosphorylation	[53]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)	OTK13JKC	MP2K6_HUMAN	Increases Phosphorylation	[52]
Serine/threonine-protein kinase PLK1 (PLK1)	OTRZX45T	PLK1_HUMAN	Decreases Expression	[34]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Activity	[51]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Increases Cleavage	[54]
C-X-C chemokine receptor type 4 (CXCR4)	OTUFSBX2	CXCR4_HUMAN	Affects Expression	[34]
E3 ubiquitin-protein ligase Mdm2 (MDM2)	OTOVXARF	MDM2_HUMAN	Decreases Expression	[34]
POU domain, class 5, transcription factor 1 (POU5F1)	OTDHHN7O	PO5F1_HUMAN	Decreases Expression	[32]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Increases Expression	[55]
Regenerating islet-derived protein 3-alpha (REG3A)	OT0BVQRB	REG3A_HUMAN	Decreases Expression	[53]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Decreases Expression	[35]
Protein patched homolog 1 (PTCH1)	OTMG07H5	PTC1_HUMAN	Affects Expression	[34]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Activity	[51]
Sonic hedgehog protein (SHH)	OTOG2BXF	SHH_HUMAN	Decreases Expression	[34]
Nuclear factor erythroid 2-related factor 2 (NFE2L2)	OT0HENJ5	NF2L2_HUMAN	Increases Expression	[42]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1)	OT2363Z9	T53I1_HUMAN	Increases Expression	[53]
Protein smoothened (SMO)	OTXXE208	SMO_HUMAN	Increases Expression	[49]
Homeobox protein NANOG (NANOG)	OTUEY1FM	NANOG_HUMAN	Decreases Expression	[49]
Axin-2 (AXIN2)	OTRMGQNU	AXIN2_HUMAN	Affects Expression	[34]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)	OT1RWFV0	PDE4D_HUMAN	Increases ADR	[56]
Focal adhesion kinase 1 (PTK2)	OT3Q1JDY	FAK1_HUMAN	Decreases Response To Substance	[57]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Affects Response To Substance	[58]
Splicing factor 45 (RBM17)	OT9ROJCL	SPF45_HUMAN	Decreases Response To Substance	[59]
Hypoxia-inducible factor 1-alpha (HIF1A)	OTADSC03	HIF1A_HUMAN	Affects Response To Substance	[60]
Neuropilin-1 (NRP1)	OTCGULYV	NRP1_HUMAN	Decreases Response To Substance	[61]
Oxysterol-binding protein 2 (OSBP2)	OTDGLB4J	OSBP2_HUMAN	Increases ADR	[56]
Proto-oncogene tyrosine-protein kinase Src (SRC)	OTETYX40	SRC_HUMAN	Decreases Response To Substance	[62]
Equilibrative nucleoside transporter 3 (SLC29A3)	OTGLX8XU	S29A3_HUMAN	Affects Transport	[63]
Probable ATP-dependent RNA helicase DDX53 (DDX53)	OTHK3EGZ	DDX53_HUMAN	Affects Response To Substance	[64]
Amphiregulin (AREG)	OTJFOR67	AREG_HUMAN	Decreases Response To Substance	[65]
Pyruvate kinase PKM (PKM)	OTLHHMC2	KPYM_HUMAN	Affects Response To Substance	[38]
Equilibrative nucleoside transporter 1 (SLC29A1)	OTLOOZZS	S29A1_HUMAN	Increases Response To Substance	[66]
Alpha-protein kinase 3 (ALPK3)	OTLUYSMO	ALPK3_HUMAN	Increases ADR	[56]
Transcription factor AP-2-alpha (TFAP2A)	OTMYT3NK	AP2A_HUMAN	Increases Response To Substance	[67]
Death-associated protein kinase 1 (DAPK1)	OTNCNUCO	DAPK1_HUMAN	Increases ADR	[68]
Cytochrome c oxidase subunit 3 (COX3)	OTNNGBYJ	COX3_HUMAN	Decreases Response To Substance	[69]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Decreases Response To Substance	[70]
Receptor tyrosine-protein kinase erbB-2 (ERBB2)	OTOAUNCK	ERBB2_HUMAN	Increases ADR	[71]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Affects Response To Substance	[72]
3-phosphoinositide-dependent protein kinase 1 (PDPK1)	OTT09ZVP	PDPK1_HUMAN	Decreases Response To Substance	[73]
Nucleophosmin (NPM1)	OTTBYYT0	NPM_HUMAN	Decreases Response To Substance	[74]
Serine/threonine-protein kinase SMG1 (SMG1)	OTTS3SXE	SMG1_HUMAN	Decreases Response To Substance	[75]
ATP-dependent DNA helicase PIF1 (PIF1)	OTUHKKVP	PIF1_HUMAN	Decreases Response To Substance	[45]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Decreases Response To Substance	[76]
Ribonucleoside-diphosphate reductase large subunit (RRM1)	OTXGQOR9	RIR1_HUMAN	Increases ADR	[77]
Olfactory receptor 4D6 (OR4D6)	OTXJKUT1	OR4D6_HUMAN	Affects Response To Substance	[64]
PDZ domain-containing protein GIPC1 (GIPC1)	OTXLVCPJ	GIPC1_HUMAN	Affects Response To Substance	[78]
Integrin-linked protein kinase (ILK)	OTYG2FD1	ILK_HUMAN	Affects Response To Substance	[58]
Poly polymerase 2 (PARP2)	OTYL81ZI	PARP2_HUMAN	Decreases Response To Substance	[79]

References

• [1] ClinicalTrials.gov (NCT04747236) Randomized Phase IIB Trial of Oral Azacytidine Plus Romidepsin Versus Investigator's Choice in PTCL
• [2] Belinostat FDA Label
• [3] A Phase II trial of Belinostat (PXD101) in patients with relapsed or refractory peripheral or cutaneous T-cell lymphoma. Br J Haematol. 2015 Mar;168(6):811-9.
• [4] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [5] Gemcitabine FDA Label
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