Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM15F0X)

Drug Name
Gefitinib Drug Info
Synonyms
Gefitini; IRE; Iressa; Irressat; Gefitinib [USAN]; ZD 1839; ZD1839; Iressa (TN); Iressa(TM); ZD-1839; CU-00000000396-1; Gefitinib,Iressa, ZD1839; Gefitinib (JAN/USAN/INN); ZD-1839, Iressa, Gefitinib; N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine; N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamide; N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine; N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine; N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine; 4-(3'-Chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline; 6-(3-morpholinopropoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine
Indication
Disease Entry ICD 11 Status REF
Colon adenocarcinoma Approved [1]
Glioblastoma 2A00 Approved [1]
Lung cancer 2C25.0 Approved [1]
Non-small-cell lung cancer 2C25.Y Approved [1]
Rectal adenocarcinoma 2B92 Approved [1]
Rectum mucinous adenocarcinoma Approved [1]
Solid tumour/cancer 2A00-2F9Z Approved [2]
Head and neck cancer 2D42 Phase 3 [2]
Urethral cancer 2C93 Phase 2 [2]
Colon cancer 2B90.Z Investigative [1]
Colon mucinous adenocarcinoma Investigative [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
123631
ChEBI ID
CHEBI:49668
CAS Number
CAS 184475-35-2
TTD Drug ID
DM15F0X
VARIDT Drug ID
DR00423
INTEDE Drug ID
DR0764
ACDINA Drug ID
D00299

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [18]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [19]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [20]
Vandetanib DMRICNP Solid tumour/cancer 2A00-2F9Z Approved [21]
Dacomitinib DMOH8VY Non-small-cell lung cancer 2C25.Y Approved [22]
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [23]
SKI-758 DMQ8E9R Ischemia 8B10-8B11 Approved [24]
Epidermal growth factor DMVONE6 Vulnerary ND56.Z Approved [22]
Merimepodib DM0HS92 Breast cancer 2C60-2C65 Approved [25]
Nitroglycerin DMQ2491 Angina pectoris BA40 Approved [26]
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [89]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [90]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [91]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [92]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [93]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [94]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Selenium DM25CGV N. A. N. A. Approved [96]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [97]
Quercetin DM3NC4M Obesity 5B81 Approved [98]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [27]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [28]
Methotrexate DM2TEOL Anterior urethra cancer Approved [4]
Folic Acid DMEMBJC Colorectal carcinoma Approved [29]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [4]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [4]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [30]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [4]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [31]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [32]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
Folic Acid DMEMBJC Colorectal carcinoma Approved [35]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [37]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [38]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [39]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [38]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [40]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [41]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic anion transporting polypeptide 1B1 (SLCO1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [42]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [43]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [5]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [44]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [5]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [45]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [46]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [47]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [48]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [45]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic anion transporting polypeptide 1B3 (SLCO1B3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [5]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [50]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [51]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [5]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [52]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [46]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [48]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [53]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [48]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [54]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [55]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [56]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [57]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [58]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [59]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [60]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [61]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [55]
Verapamil DMA7PEW Angina pectoris BA40 Approved [62]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [63]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [64]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [65]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [58]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [62]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [66]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [67]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [68]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [69]
Propranolol DM79NTF Angina pectoris BA40 Approved [70]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [71]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [72]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [73]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [74]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [75]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [76]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [77]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [78]
Verapamil DMA7PEW Angina pectoris BA40 Approved [79]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [74]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [80]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [80]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [81]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [82]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [83]
Methotrexate DM2TEOL Anterior urethra cancer Approved [84]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [86]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [87]
Folic Acid DMEMBJC Colorectal carcinoma Approved [88]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sulfhydryl oxidase 1 (QSOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [103]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [104]
Testosterone DM7HUNW Hot flushes GA30 Approved [105]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [105]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [107]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Methotrexate DM2TEOL Anterior urethra cancer Approved [109]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [110]
Panobinostat DM58WKG Chronic graft versus host disease Approved [111]
Testosterone DM7HUNW Hot flushes GA30 Approved [105]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [105]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [112]
Febuxostat DMDEXQ0 Hyperuricaemia 5C55.Y Approved [113]
Ethanol DMDRQZU Chronic pain MG30 Approved [114]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon alpha-inducible protein 6 (IFI6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [116]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [117]
Selenium DM25CGV N. A. N. A. Approved [118]
Methotrexate DM2TEOL Anterior urethra cancer Approved [119]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [120]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [119]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [121]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibroblast growth factor 6 (FGF6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [123]
Arsenic DMTL2Y1 N. A. N. A. Approved [124]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [125]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [126]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [127]
AMINOHIPPURIC ACID DMUN54G Discovery agent N.A. Investigative [128]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Ski oncogene (SKI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [118]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [104]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [129]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [130]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [131]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [132]
Arsenic DMTL2Y1 N. A. N. A. Approved [133]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [134]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [135]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Erythropoietin receptor (EPOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [138]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [107]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [140]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [141]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [142]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [135]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [143]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [144]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [145]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [94]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [146]
Methotrexate DM2TEOL Anterior urethra cancer Approved [147]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [148]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [150]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [151]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [152]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [153]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [154]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [155]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [155]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [156]
Ethanol DMDRQZU Chronic pain MG30 Approved [157]
Menthol DMG2KW7 Back pain ME84.Z Approved [158]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [159]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [160]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [94]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [162]
Methotrexate DM2TEOL Anterior urethra cancer Approved [163]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [164]
Quercetin DM3NC4M Obesity 5B81 Approved [165]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [166]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [167]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [168]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2F1 (CYP2F1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [169]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [170]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [171]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [169]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [127]
Drug(s) Affected By Replication protein A 70 kDa DNA-binding subunit (RPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [172]
Leflunomide DMR8ONJ Arthritis FA20 Approved [173]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [129]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [174]
Clozapine DMFC71L Schizophrenia 6A20 Approved [175]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [140]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adenosine receptor A1 (ADORA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [176]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
Testosterone DM7HUNW Hot flushes GA30 Approved [105]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [105]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [130]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [177]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [131]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [178]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [179]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [135]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 14-3-3 protein sigma (SFN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Methotrexate DM2TEOL Anterior urethra cancer Approved [180]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [164]
Quercetin DM3NC4M Obesity 5B81 Approved [181]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [151]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [164]
Panobinostat DM58WKG Chronic graft versus host disease Approved [143]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [182]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [183]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [184]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA mismatch repair protein Mlh1 (MLH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [185]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [131]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [140]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [186]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [187]
Arsenic DMTL2Y1 N. A. N. A. Approved [188]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [189]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [190]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [191]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glycine--tRNA ligase (GARS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [192]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [193]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [194]
Leflunomide DMR8ONJ Arthritis FA20 Approved [173]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [184]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [184]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [195]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [184]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [196]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Epidermal growth factor receptor substrate 15 (EPS15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [197]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [129]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [130]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [174]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [140]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [185]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [198]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [127]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [199]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neuronal pentraxin-2 (NPTX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [200]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [123]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [107]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [140]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [201]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [201]
Arsenic DMTL2Y1 N. A. N. A. Approved [133]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [134]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [202]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Leptin receptor (LEPR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [203]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [104]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [123]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [195]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [204]
Ketamine DMT5HA4 Anaesthesia 9A78.6 Approved [205]
Arsenic DMTL2Y1 N. A. N. A. Approved [133]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [206]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [135]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [207]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neural retina-specific leucine zipper protein (NRL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [208]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [209]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [208]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [187]
Urethane DM7NSI0 N. A. N. A. Phase 4 [210]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [211]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [212]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [213]
TTNPB DMSABD0 Discovery agent N.A. Investigative [208]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
Selenium DM25CGV N. A. N. A. Approved [118]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [214]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [195]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [174]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [215]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [134]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [216]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [217]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinal guanylyl cyclase 1 (GUCY2D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [174]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [178]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [127]
ORG2058 DMH1M6N Discovery agent N.A. Investigative [218]
Drug(s) Affected By Cell growth regulator with RING finger domain protein 1 (CGRRF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [130]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [219]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [220]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [212]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [221]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [143]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 9 (DUSP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [222]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [223]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [130]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [224]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [140]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [222]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [134]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [225]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [226]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [16]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [227]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [227]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [228]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [16]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [227]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [229]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [230]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [16]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [231]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinoblastoma-associated protein (RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [232]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [233]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [234]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [235]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [236]
Methotrexate DM2TEOL Anterior urethra cancer Approved [237]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [238]
Quercetin DM3NC4M Obesity 5B81 Approved [239]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [240]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [241]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [242]
Selenium DM25CGV N. A. N. A. Approved [118]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [243]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [244]
Quercetin DM3NC4M Obesity 5B81 Approved [150]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [245]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [246]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [248]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [249]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [236]
Methotrexate DM2TEOL Anterior urethra cancer Approved [250]
Quercetin DM3NC4M Obesity 5B81 Approved [150]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [251]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Panobinostat DM58WKG Chronic graft versus host disease Approved [143]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [252]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Telomerase reverse transcriptase (TERT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [253]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [153]
Selenium DM25CGV N. A. N. A. Approved [254]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [255]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [256]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [257]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [258]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [259]
Testosterone DM7HUNW Hot flushes GA30 Approved [105]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [260]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [261]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [262]
Etretinate DM2CZFA Keratosis ED56 Approved [263]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [162]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [264]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [265]
Quercetin DM3NC4M Obesity 5B81 Approved [266]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [267]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [268]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [269]
Quercetin DM3NC4M Obesity 5B81 Approved [270]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [271]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [272]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [273]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [274]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [271]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [275]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [174]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [276]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [94]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [277]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [153]
Selenium DM25CGV N. A. N. A. Approved [278]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [279]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [235]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [280]
Methotrexate DM2TEOL Anterior urethra cancer Approved [281]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [148]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [282]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [283]
Fructose DM43AN2 Vomiting MD90 Approved [81]
Ketoprofen DMRKXPT Bursitis Approved [81]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [284]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [285]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [286]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [287]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [288]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [290]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [291]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [292]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [291]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [293]
Selenium DM25CGV N. A. N. A. Approved [294]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [295]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [296]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [297]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clindamycin DM15HL8 Acne vulgaris ED80 Approved [298]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [298]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [185]
Cefepime DMHVWIK Bacterial infection 1A00-1C4Z Approved [298]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [159]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [219]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [299]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [300]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [298]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Estrogen receptor (ESR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [301]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [302]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [303]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [91]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [304]
Quercetin DM3NC4M Obesity 5B81 Approved [305]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [306]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [303]
Estrone DM5T6US Acne vulgaris ED80 Approved [307]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [308]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trastuzumab DMZQOUX Breast cancer 2C60-2C65 Approved [81]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [309]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [310]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [277]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
Selenium DM25CGV N. A. N. A. Approved [118]
Methotrexate DM2TEOL Anterior urethra cancer Approved [109]
Quercetin DM3NC4M Obesity 5B81 Approved [239]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [311]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By HLA class II histocompatibility antigen, DO alpha chain (HLA-DOA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [156]
Saquinavir DMG814N Human immunodeficiency virus infection 1C62 Approved [298]
Indapamide DMGN1PW Edema MG29 Approved [298]
Bortezomib DMNO38U Leukemia Approved [312]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [298]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [313]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [314]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [213]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [315]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [316]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [176]
Selenium DM25CGV N. A. N. A. Approved [118]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [317]
Quercetin DM3NC4M Obesity 5B81 Approved [318]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [319]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [130]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [174]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [320]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [321]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [322]
Quercetin DM3NC4M Obesity 5B81 Approved [323]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [324]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [197]
Testosterone DM7HUNW Hot flushes GA30 Approved [105]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [105]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [184]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [129]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By High mobility group protein B1 (HMGB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [325]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [326]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [327]
Testosterone DM7HUNW Hot flushes GA30 Approved [105]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [105]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [129]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [328]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [130]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [329]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [330]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [262]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [331]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [332]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [331]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [333]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [334]
Methotrexate DM2TEOL Anterior urethra cancer Approved [335]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [336]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [337]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [160]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [94]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [338]
Selenium DM25CGV N. A. N. A. Approved [118]
Etretinate DM2CZFA Keratosis ED56 Approved [339]
Methotrexate DM2TEOL Anterior urethra cancer Approved [281]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [340]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [168]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [341]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [176]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [288]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [342]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [343]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [344]
Methotrexate DM2TEOL Anterior urethra cancer Approved [281]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [345]
Quercetin DM3NC4M Obesity 5B81 Approved [346]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [347]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [348]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [176]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [288]
Selenium DM25CGV N. A. N. A. Approved [96]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [349]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [333]
Methotrexate DM2TEOL Anterior urethra cancer Approved [350]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [351]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [352]
Quercetin DM3NC4M Obesity 5B81 Approved [353]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Platelet endothelial cell adhesion molecule (PECAM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [354]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [355]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [356]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [357]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [358]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [359]
Folic Acid DMEMBJC Colorectal carcinoma Approved [360]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [361]
Vitamin B3 DMQVRZH Chronic renal failure GB61.Z Approved [362]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [363]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [364]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [365]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [235]
Quercetin DM3NC4M Obesity 5B81 Approved [366]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [367]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [368]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [369]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [370]
Testosterone DM7HUNW Hot flushes GA30 Approved [371]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alanine aminotransferase 1 (GPT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [81]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [372]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [373]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [81]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [81]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [374]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [10]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [10]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [375]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [376]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [377]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [378]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [302]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [234]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [379]
Selenium DM25CGV N. A. N. A. Approved [118]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [279]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [380]
Methotrexate DM2TEOL Anterior urethra cancer Approved [109]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DnaJ homolog subfamily B member 1 (DNAJB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [381]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [160]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [382]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [383]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [271]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [384]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [385]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [194]
Leflunomide DMR8ONJ Arthritis FA20 Approved [173]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [386]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [387]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [388]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [285]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [389]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [390]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [391]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [392]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [393]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [394]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [395]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [387]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [396]
Paclitaxel DMLB81S Breast carcinoma Approved [397]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [398]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [386]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [81]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [285]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [389]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-1 (CASP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [399]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [293]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [297]
Quercetin DM3NC4M Obesity 5B81 Approved [152]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [120]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [400]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [401]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [402]
Testosterone DM7HUNW Hot flushes GA30 Approved [403]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Quercetin DM3NC4M Obesity 5B81 Approved [239]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [251]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [404]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [405]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [223]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [193]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [145]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [104]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [406]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain F (HLA-F)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [118]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [298]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [407]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [408]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [409]
Repaglinide DM5SXUV Diabetic complication 5A2Y Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [410]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [107]
Saquinavir DMG814N Human immunodeficiency virus infection 1C62 Approved [298]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [159]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [411]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [412]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [413]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [378]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [365]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [414]
Selenium DM25CGV N. A. N. A. Approved [118]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [321]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [279]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [415]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [416]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [417]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [234]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [338]
Etretinate DM2CZFA Keratosis ED56 Approved [263]
Prednisone DM2HG4X Acute asthma CA23 Approved [418]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [332]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [419]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [420]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [421]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [422]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [364]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [423]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [279]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [424]
Quercetin DM3NC4M Obesity 5B81 Approved [425]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [426]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [427]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [424]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor B (CDKN2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
Prednisone DM2HG4X Acute asthma CA23 Approved [418]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [428]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [429]
Testosterone DM7HUNW Hot flushes GA30 Approved [105]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [105]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [430]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [431]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [432]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [433]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [434]
Quercetin DM3NC4M Obesity 5B81 Approved [150]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [435]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [436]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [434]
Ethacrynic acid DM60QMR Edema MG29 Approved [437]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [438]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [233]
Prednisone DM2HG4X Acute asthma CA23 Approved [418]
Methotrexate DM2TEOL Anterior urethra cancer Approved [439]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [440]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [441]
Fluoxetine DM3PD2C Bipolar depression Approved [442]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [443]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [444]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [383]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [445]
Epinephrine DM3KJBC Acute asthma CA23 Approved [446]
Quercetin DM3NC4M Obesity 5B81 Approved [447]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [340]
Fructose DM43AN2 Vomiting MD90 Approved [448]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [449]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [450]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [451]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [452]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [453]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [454]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [455]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [456]
Methotrexate DM2TEOL Anterior urethra cancer Approved [281]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [457]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [458]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [459]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor E2F1 (E2F1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [460]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [329]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [461]
Selenium DM25CGV N. A. N. A. Approved [118]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [419]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [236]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [462]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [463]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caveolin-1 (CAV1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [378]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [176]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [464]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [465]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [83]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [410]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [466]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [130]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sequestosome-1 (SQSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [422]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [364]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [117]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [467]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [162]
Methotrexate DM2TEOL Anterior urethra cancer Approved [109]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [120]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [271]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [222]
Selenium DM25CGV N. A. N. A. Approved [118]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [120]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [402]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [184]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [184]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [184]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [468]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [469]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [184]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [470]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [471]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [472]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [473]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [262]
Selenium DM25CGV N. A. N. A. Approved [118]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [474]
Methotrexate DM2TEOL Anterior urethra cancer Approved [281]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [148]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [475]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [338]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [476]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [477]
Estrone DM5T6US Acne vulgaris ED80 Approved [478]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [479]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [480]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [481]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [482]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [483]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By MHC class I polypeptide-related sequence B (MICB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [109]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Panobinostat DM58WKG Chronic graft versus host disease Approved [143]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [484]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [107]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [219]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [485]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [132]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By MHC class I polypeptide-related sequence A (MICA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [484]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [129]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [195]
Folic Acid DMEMBJC Colorectal carcinoma Approved [486]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [487]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [219]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [201]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [201]
Arsenic DMTL2Y1 N. A. N. A. Approved [133]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [189]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Estrogen receptor beta (ESR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [176]
Quercetin DM3NC4M Obesity 5B81 Approved [488]
Estrone DM5T6US Acne vulgaris ED80 Approved [489]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [490]
Testosterone DM7HUNW Hot flushes GA30 Approved [491]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [492]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [493]
Mestranol DMG3F94 Contraception QA21 Approved [494]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [495]
Paclitaxel DMLB81S Breast carcinoma Approved [386]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine protease HTRA1 (HTRA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [409]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [123]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [195]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [159]
Tirbanibulin DMJNV4O Actinic keratosis EK90.0 Approved [496]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [497]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [219]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [140]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [496]
Arsenic DMTL2Y1 N. A. N. A. Approved [496]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Major histocompatibility complex class I-related gene protein (MR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [298]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [298]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [164]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [298]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [298]
Repaglinide DM5SXUV Diabetic complication 5A2Y Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [106]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Autophagy protein 5 (ATG5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [498]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [272]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [499]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [500]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [274]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [501]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [129]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [502]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [313]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [174]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor SOX-17 (SOX17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [503]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [503]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [503]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [503]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [503]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [504]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [159]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [503]
Ziprasidone DMM58JY Bipolar disorder 6A60 Approved [503]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [505]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By MARVEL domain-containing protein 1 (MARVELD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [130]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [187]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [313]
Paclitaxel DMLB81S Breast carcinoma Approved [506]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [507]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [507]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [313]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [212]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [213]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By GTPase KRas (KRAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [508]
Quercetin DM3NC4M Obesity 5B81 Approved [165]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [409]
Tiazofurin DM5JWV9 Solid tumour/cancer 2A00-2F9Z Approved [509]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [510]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [197]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [511]
Testosterone enanthate DMB6871 N. A. N. A. Approved [512]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [513]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [156]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [514]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [83]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Panobinostat DM58WKG Chronic graft versus host disease Approved [143]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [327]
Testosterone DM7HUNW Hot flushes GA30 Approved [105]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [105]
Leflunomide DMR8ONJ Arthritis FA20 Approved [173]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [123]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [195]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Membrane-associated progesterone receptor component 1 (PGRMC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [199]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [409]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [129]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [130]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [174]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [140]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [132]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [189]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [135]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [515]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [516]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [475]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [517]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [518]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [519]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [340]
Ethacrynic acid DM60QMR Edema MG29 Approved [520]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [319]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [521]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [522]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [523]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [433]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [231]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [524]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [525]
Quercetin DM3NC4M Obesity 5B81 Approved [526]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [527]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [381]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RNA-binding protein 7 (RBM7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [528]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [129]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [130]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [219]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [529]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [140]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [187]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [530]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cell death regulator Aven (AVEN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [130]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [219]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [531]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [313]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [220]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [313]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [313]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [127]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Forkhead box protein O3 (FOXO3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [532]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [533]
Quercetin DM3NC4M Obesity 5B81 Approved [165]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [534]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [535]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [383]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [536]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Leflunomide DMR8ONJ Arthritis FA20 Approved [173]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [106]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phospholipase B-like 1 (PLBD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Panobinostat DM58WKG Chronic graft versus host disease Approved [143]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [130]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [174]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [537]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [136]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [135]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [143]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [538]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [127]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [539]
Methotrexate DM2TEOL Anterior urethra cancer Approved [281]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [540]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [541]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [542]
Paclitaxel DMLB81S Breast carcinoma Approved [543]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [544]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [413]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [545]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [249]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Securin (PTTG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [546]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [547]
Testosterone DM7HUNW Hot flushes GA30 Approved [105]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [105]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [548]
Leflunomide DMR8ONJ Arthritis FA20 Approved [173]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amphiregulin (AREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [329]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [116]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [338]
Methotrexate DM2TEOL Anterior urethra cancer Approved [250]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [97]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [549]
Estrone DM5T6US Acne vulgaris ED80 Approved [550]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [223]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [104]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [551]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pleckstrin homology-like domain family A member 2 (PHLDA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [534]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [400]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [409]
Panobinostat DM58WKG Chronic graft versus host disease Approved [143]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [153]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [130]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aurora kinase A (AURKA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [325]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [162]
Methotrexate DM2TEOL Anterior urethra cancer Approved [552]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [462]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [553]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [162]
Testosterone DM7HUNW Hot flushes GA30 Approved [105]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA excision repair protein ERCC-1 (ERCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [118]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [409]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [143]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [554]
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [555]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [556]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [140]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [557]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [558]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [235]
Quercetin DM3NC4M Obesity 5B81 Approved [559]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [535]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [560]
Panobinostat DM58WKG Chronic graft versus host disease Approved [143]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [561]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [562]
Testosterone DM7HUNW Hot flushes GA30 Approved [403]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ceramide transfer protein (CERT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [118]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [195]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [174]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [563]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [187]
Arsenic DMTL2Y1 N. A. N. A. Approved [133]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [564]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [135]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [118]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA repair protein RAD51 homolog 1 (RAD51)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [260]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [565]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [566]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [567]
Testosterone DM7HUNW Hot flushes GA30 Approved [105]
Quizartinib DM8Y4JS Acute myeloid leukaemia 2A60 Approved [568]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [105]
Leflunomide DMR8ONJ Arthritis FA20 Approved [173]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Oncostatin-M-specific receptor subunit beta (OSMR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Leflunomide DMR8ONJ Arthritis FA20 Approved [173]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [313]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [569]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [530]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [570]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [135]
Paclitaxel DMLB81S Breast carcinoma Approved [571]
Urethane DM7NSI0 N. A. N. A. Phase 4 [210]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protransforming growth factor alpha (TGFA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [176]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [176]
Methotrexate DM2TEOL Anterior urethra cancer Approved [250]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [572]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [573]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [574]
Leflunomide DMR8ONJ Arthritis FA20 Approved [173]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [195]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [219]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 3 (DUSP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [129]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [130]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [174]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [219]
Paclitaxel DMLB81S Breast carcinoma Approved [575]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [201]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [201]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [136]
Arsenic DMTL2Y1 N. A. N. A. Approved [576]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [378]
Selenium DM25CGV N. A. N. A. Approved [118]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [577]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [149]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [578]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [579]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [368]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [580]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pericentrin (PCNT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [123]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [469]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [187]
Arsenic DMTL2Y1 N. A. N. A. Approved [133]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [135]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [469]
Urethane DM7NSI0 N. A. N. A. Phase 4 [210]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [199]
Hexadecanoic acid DMWUXDZ Discovery agent N.A. Investigative [581]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Coronin-1C (CORO1C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [582]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [107]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [174]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [219]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [132]
Arsenic DMTL2Y1 N. A. N. A. Approved [133]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [134]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [142]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [505]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [505]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ribonucleoside-diphosphate reductase large subunit (RRM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [583]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [325]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [584]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [195]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [585]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Epidermal growth factor receptor (EGFR) TTGKNB4 EGFR_HUMAN Inhibitor [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [4]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [5]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [5]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [7]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [8]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Gene/Protein Processing [9]
Adenosine receptor A1 (ADORA1) OTI7X39E AA1R_HUMAN Gene/Protein Processing [9]
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Protein Interaction/Cellular Processes [10]
Amphiregulin (AREG) OTJFOR67 AREG_HUMAN Drug Response [11]
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Drug Response [12]
Autophagy protein 5 (ATG5) OT4T5SMS ATG5_HUMAN Gene/Protein Processing [13]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [14]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Drug Response [15]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [16]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Drug Response [17]

References

1 Gefitinib FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4941).
3 Gefitinib ('Iressa', ZD1839) and new epidermal growth factor receptor inhibitors. Br J Cancer. 2004 Feb 9;90(3):566-72.
4 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
5 Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66.
6 Gefitinib-phenytoin interaction is not correlated with the C-erythromycin breath test in healthy male volunteers. Br J Clin Pharmacol. 2009 Aug;68(2):226-37.
7 Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes. Clin Cancer Res. 2007 Jun 15;13(12):3731-7.
8 Pharmacokinetic drug interactions of gefitinib with rifampicin, itraconazole and metoprolol. Clin Pharmacokinet. 2005;44(10):1067-81.
9 Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol Rep. 2006 Jun;15(6):1453-60.
10 Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes. Toxicol Lett. 2018 Jul;291:138-148. doi: 10.1016/j.toxlet.2018.04.010. Epub 2018 Apr 12.
11 Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839). Hum Mol Genet. 2004 Dec 15;13(24):3029-43. doi: 10.1093/hmg/ddh331. Epub 2004 Oct 20.
12 Aurora-A promotes gefitinib resistance via a NF-B signaling pathway in p53 knockdown lung cancer cells. Biochem Biophys Res Commun. 2011 Feb 11;405(2):168-72. doi: 10.1016/j.bbrc.2011.01.001. Epub 2011 Jan 7.
13 EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS One. 2011;6(6):e18691. doi: 10.1371/journal.pone.0018691. Epub 2011 Jun 2.
14 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
15 BIM induction of apoptosis triggered by EGFR-sensitive and resistance cell lines of non-small-cell lung cancer. Med Oncol. 2011 Jun;28(2):572-7. doi: 10.1007/s12032-010-9470-y. Epub 2010 Mar 17.
16 Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicol Sci. 2010 Dec; 118(2):485-500.
17 Pharmacogenetics of ABCG2 and adverse reactions to gefitinib. J Natl Cancer Inst. 2006 Dec 6;98(23):1739-42.
18 Nasopharyngeal carcinoma: Current treatment options and future directions. J Nasopharyng Carcinoma, 2014, 1(16): e16.
19 Triple negative breast cancer--current status and prospective targeted treatment based on HER1 (EGFR), TOP2A and C-MYC gene assessment. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2009 Mar;153(1):13-7.
20 Quantitative prediction of fold resistance for inhibitors of EGFR. Biochemistry. 2009 Sep 8;48(35):8435-48.
21 A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
22 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797).
23 Boehringer Ingelheim. Product Development Pipeline. June 2 2009.
24 Synthesis and Src kinase inhibitory activity of a series of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-furyl-3-quinolinecarbonitriles. J Med Chem. 2006 Dec 28;49(26):7868-76.
25 Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
26 Emerging drugs for diabetic foot ulcers. Expert Opin Emerg Drugs. 2006 Nov;11(4):709-24.
27 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
28 MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
29 Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
30 Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
31 Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
32 Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
33 Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25.
34 Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003 Sep 1;63(17):5538-43.
35 The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9.
36 Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10.
37 Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93.
38 Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51.
39 The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Lett. 2016 Jun 28;376(1):165-72.
40 Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res. 2009 Feb;26(2):480-7.
41 Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood. 2004 Nov 1;104(9):2940-2.
42 Preclinical Mouse Models To Study Human OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions in Vivo. Mol Pharm. 2015 Dec 7;12(12):4259-69.
43 Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81.
44 Identification of drugs and drug metabolites as substrates of multidrug resistance protein 2 (MRP2) using triple-transfected MDCK-OATP1B1-UGT1A1-MRP2 cells. Br J Pharmacol. 2012 Mar;165(6):1836-1847.
45 The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15. Pharmacogenet Genomics. 2008 May;18(5):424-33.
46 Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. Eur J Clin Pharmacol. 2007 Dec;63(12):1161-9.
47 Rifampicin alters atorvastatin plasma concentration on the basis of SLCO1B1 521T>C polymorphism. Clin Chim Acta. 2009 Jul;405(1-2):49-52.
48 FDA Drug Development and Drug Interactions
49 LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology. 2001 Jun;120(7):1689-99.
50 Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol. 2008 Apr 14;584(1):57-65.
51 Influence of non-steroidal anti-inflammatory drugs on organic anion transporting polypeptide (OATP) 1B1- and OATP1B3-mediated drug transport. Drug Metab Dispos. 2011 Jun;39(6):1047-53.
52 Relevance of conserved lysine and arginine residues in transmembrane helices for the transport activity of organic anion transporting polypeptide 1B3. Br J Pharmacol. 2010 Feb 1;159(3):698-708.
53 Impact of OATP transporters on pharmacokinetics. Br J Pharmacol. 2009 Oct;158(3):693-705.
54 Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer. 2007 Mar 1;109(5):957-65.
55 Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47.
56 Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.
57 Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone. Drug Metab Dispos. 2013 Feb;41(2):263-9.
58 Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
59 Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates. Br J Pharmacol. 2012 Apr;165(8):2787-98.
60 Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos. 2007 Apr;28(3):151-6.
61 The metabolism of zidovudine by human liver microsomes in vitro: formation of 3'-amino-3'-deoxythymidine. Biochem Pharmacol. 1994 Jul 19;48(2):267-76.
62 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
63 Inhibitory effects of anticancer drugs on dextromethorphan-O-demethylase activity in human liver microsomes. Cancer Chemother Pharmacol. 1993;32(6):491-5.
64 Effect of genetic polymorphism on the metabolism of endogenous neuroactive substances, progesterone and p-tyramine, catalyzed by CYP2D6. Brain Res Mol Brain Res. 2004 Oct 22;129(1-2):117-23.
65 CYP2D6 polymorphisms and tamoxifen metabolism: clinical relevance. Curr Oncol Rep. 2010 Jan;12(1):7-15.
66 Inhibition of cytochrome P450 2D6: structure-activity studies using a series of quinidine and quinine analogues. Chem Res Toxicol. 2003 Apr;16(4):450-9.
67 Effects of propofol on human hepatic microsomal cytochrome P450 activities. Xenobiotica. 1998 Sep;28(9):845-53.
68 Pharmacogenetics of schizophrenia. Am J Med Genet. 2000 Spring;97(1):98-106.
69 Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol. 1999 Mar;73(2):65-70.
70 Structure-activity relationship for human cytochrome P450 substrates and inhibitors. Drug Metab Rev. 2002 Feb-May;34(1-2):69-82.
71 Drug related genetic polymorphisms affecting adverse reactions to methotrexate, vinblastine, doxorubicin and cisplatin in patients with urothelial cancer. J Urol. 2008 Dec;180(6):2389-95.
72 Human prostate CYP3A5: identification of a unique 5'-untranslated sequence and characterization of purified recombinant protein. Biochem Biophys Res Commun. 1999 Jul 14;260(3):676-81.
73 Polymorphisms in cytochrome P4503A5 (CYP3A5) may be associated with race and tumor characteristics, but not metabolism and side effects of tamoxifen in breast cancer patients. Cancer Lett. 2005 Jan 10;217(1):61-72.
74 Drug Interactions Flockhart Table
75 Induction of hepatic CYP2E1 by a subtoxic dose of acetaminophen in rats: increase in dichloromethane metabolism and carboxyhemoglobin elevation. Drug Metab Dispos. 2007 Oct;35(10):1754-8.
76 Urinary 6 beta-hydroxycortisol excretion in rheumatoid arthritis. Br J Rheumatol. 1997 Jan;36(1):54-8.
77 Clinical pharmacokinetics of imatinib. Clin Pharmacokinet. 2005;44(9):879-94.
78 Kinetics and regulation of cytochrome P450-mediated etoposide metabolism. Drug Metab Dispos. 2004 Sep;32(9):993-1000.
79 Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil. Drug Metab Dispos. 2005 May;33(5):664-71.
80 Localization of breast cancer resistance protein (Bcrp) in endocrine organs and inhibition of its transport activity by steroid hormones. Cell Tissue Res. 2012 Aug;349(2):551-63. doi: 10.1007/s00441-012-1417-5. Epub 2012 May 13.
81 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
82 ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin. Clin Pharmacol Ther. 2010 May;87(5):558-62.
83 Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
84 Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
85 Activation of beta-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells. J Neurochem. 2008 Aug;106(4):1855-65. doi: 10.1111/j.1471-4159.2008.05537.x. Epub 2008 Jul 4.
86 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
87 Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps. Cancer Biol Ther. 2005 Jul;4(7):747-52.
88 Folate deprivation induces BCRP (ABCG2) expression and mitoxantrone resistance in Caco-2 cells. Int J Cancer. 2008 Oct 1;123(7):1712-20.
89 Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors. J Med Chem. 2011 Mar 10;54(5):1347-55. doi: 10.1021/jm101396q. Epub 2011 Feb 15.
90 Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004 May 20;350(21):2129-39. doi: 10.1056/NEJMoa040938. Epub 2004 Apr 29.
91 The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res. 2005 Jan 1;65(1):18-25.
92 A fine-needle aspirate-based vulnerability assay identifies polo-like kinase 1 as a mediator of gemcitabine resistance in pancreatic cancer. Mol Cancer Ther. 2010 Feb;9(2):311-8. doi: 10.1158/1535-7163.MCT-09-0693. Epub 2010 Jan 26.
93 Prediction of chemosensitivity using multigene analysis in head and neck squamous cell carcinoma. Oncology. 2007;73(1-2):104-11. doi: 10.1159/000120998. Epub 2008 Mar 13.
94 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
95 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
96 Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
97 Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. Surgery. 2005 Sep;138(3):415-21. doi: 10.1016/j.surg.2005.06.030.
98 Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3). Cell Biochem Funct. 2011 Mar;29(2):87-95. doi: 10.1002/cbf.1725. Epub 2011 Feb 9.
99 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
100 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
101 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
102 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
103 Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
104 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
105 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
106 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
107 The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
108 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
109 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
110 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
111 SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-B/STAT3 complex to its promoter in malignant lymphoid cells. Cell Death Dis. 2013 May 16;4(5):e635. doi: 10.1038/cddis.2013.159.
112 Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
113 Febuxostat Increases Ventricular Arrhythmogenesis Through Calcium Handling Dysregulation in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Toxicol Sci. 2022 Sep 24;189(2):216-224. doi: 10.1093/toxsci/kfac073.
114 Cardiac toxicity from ethanol exposure in human-induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci. 2019 May 1;169(1):280-292.
115 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
116 Analysis of estrogen agonism and antagonism of tamoxifen, raloxifene, and ICI182780 in endometrial cancer cells: a putative role for the epidermal growth factor receptor ligand amphiregulin. J Soc Gynecol Investig. 2005 Oct;12(7):e55-67.
117 MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
118 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
119 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
120 Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
121 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
122 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
123 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
124 Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci. 2014 Jun;139(2):328-37. doi: 10.1093/toxsci/kfu053. Epub 2014 Mar 27.
125 Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21737-42. doi: 10.1073/pnas.1007863107. Epub 2010 Nov 22.
126 Malathion induced cancer-linked gene expression in human lymphocytes. Environ Res. 2020 Mar;182:109131. doi: 10.1016/j.envres.2020.109131. Epub 2020 Jan 10.
127 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
128 Induction of fibroblast growth factor-9 and interleukin-1alpha gene expression by motorcycle exhaust particulate extracts and benzo(a)pyrene in human lung adenocarcinoma cells. Toxicol Sci. 2005 Oct;87(2):483-96. doi: 10.1093/toxsci/kfi251. Epub 2005 Jul 7.
129 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
130 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
131 Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray. Cancer Lett. 2005 Apr 8;220(2):197-210.
132 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
133 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
134 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
135 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
136 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
137 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
138 In vitro dual effect of arsenic trioxide on hemopoiesis: inhibition of erythropoiesis and stimulation of megakaryocytic maturation. Blood Cells Mol Dis. 2006 Jan-Feb;36(1):59-76. doi: 10.1016/j.bcmd.2005.10.005. Epub 2005 Dec 15.
139 The distinct erythropoietin functions that promote cell survival and proliferation are affected by aluminum exposure through mechanisms involving erythropoietin receptor. Biochim Biophys Acta. 2005 Mar 22;1743(1-2):29-36. doi: 10.1016/j.bbamcr.2004.08.004.
140 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
141 Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
142 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
143 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
144 Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
145 DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
146 The thioredoxin system mediates redox-induced cell death in human colon cancer cells: implications for the mechanism of action of anticancer agents. Cancer Res. 2008 Oct 15;68(20):8269-77. doi: 10.1158/0008-5472.CAN-08-2010.
147 Development of an alternative zebrafish model for drug-induced intestinal toxicity. J Appl Toxicol. 2018 Feb;38(2):259-273. doi: 10.1002/jat.3520. Epub 2017 Oct 13.
148 Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. 2005 Jul 7;5:74. doi: 10.1186/1471-2407-5-74.
149 Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2716-23.
150 Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
151 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
152 Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
153 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
154 Hydroquinone Exposure Worsens Rheumatoid Arthritis through the Activation of the Aryl Hydrocarbon Receptor and Interleukin-17 Pathways. Antioxidants (Basel). 2021 Jun 7;10(6):929. doi: 10.3390/antiox10060929.
155 Circulating endothelial progenitor cells in multiple myeloma: implications and significance. Blood. 2005 Apr 15;105(8):3286-94. doi: 10.1182/blood-2004-06-2101. Epub 2004 Dec 23.
156 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
157 Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC). Front Microbiol. 2015 Dec 22;6:1452. doi: 10.3389/fmicb.2015.01452. eCollection 2015.
158 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
159 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
160 Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
161 Chromium III histidinate exposure modulates gene expression in HaCaT human keratinocytes exposed to oxidative stress. Biol Trace Elem Res. 2010 Oct;137(1):23-39.
162 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
163 A dual role of p21waf1/cip1 gene in apoptosis of HEp-2 treated with cisplatin or methotrexate. Cancer Gene Ther. 2008 Sep;15(9):576-90. doi: 10.1038/cgt.2008.28. Epub 2008 May 16.
164 Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
165 Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Int J Mol Sci. 2023 Mar 15;24(6):5604. doi: 10.3390/ijms24065604.
166 The Effect of GADD45a on Furazolidone-Induced S-Phase Cell-Cycle Arrest in Human Hepatoma G2 Cells. J Biochem Mol Toxicol. 2015 Oct;29(10):489-495. doi: 10.1002/jbt.21719. Epub 2015 Jun 11.
167 Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells. Oncogene. 2004 Jun 3;23(26):4614-23. doi: 10.1038/sj.onc.1207598.
168 D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
169 Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol Toxicol. 2012 Apr;28(2):69-87.
170 Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. BMC Genomics. 2006 Apr 3;7:68. doi: 10.1186/1471-2164-7-68.
171 Human drug metabolism genes in parathion-and estrogen-treated breast cells. Int J Mol Med. 2007 Dec;20(6):875-81.
172 XPC is essential for nucleotide excision repair of zidovudine-induced DNA damage in human hepatoma cells. Toxicol Appl Pharmacol. 2011 Mar 1;251(2):155-62. doi: 10.1016/j.taap.2010.12.009. Epub 2010 Dec 28.
173 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
174 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
175 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
176 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
177 New 2,6,9-trisubstituted adenines as adenosine receptor antagonists: a preliminary SAR profile. Purinergic Signal. 2007 Sep;3(4):339-46. doi: 10.1007/s11302-007-9068-9. Epub 2007 Sep 19.
178 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
179 Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
180 Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
181 Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol. 2008 Jun;46(6):2042-53. doi: 10.1016/j.fct.2008.01.049. Epub 2008 Feb 7.
182 Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
183 Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenase. J Biol Chem. 2013 Oct 4;288(40):28792-800. doi: 10.1074/jbc.M113.491365. Epub 2013 Aug 12.
184 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
185 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
186 Expression and promoter methylation status of mismatch repair gene hMLH1 and hMSH2 in epithelial ovarian cancer. Aust N Z J Obstet Gynaecol. 2008 Oct;48(5):505-9. doi: 10.1111/j.1479-828X.2008.00892.x.
187 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
188 Epigenetic alteration of mismatch repair genes in the population chronically exposed to arsenic in West Bengal, India. Environ Res. 2018 May;163:289-296. doi: 10.1016/j.envres.2018.01.002. Epub 2018 Feb 27.
189 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
190 DNA demethylation by 5-aza-2-deoxycytidine treatment abrogates 17 beta-estradiol-induced cell growth and restores expression of DNA repair genes in human breast cancer cells. Cancer Lett. 2012 Mar;316(1):62-9. doi: 10.1016/j.canlet.2011.10.022. Epub 2011 Oct 23.
191 Exploring pradimicin-IRD antineoplastic mechanisms and related DNA repair pathways. Chem Biol Interact. 2023 Feb 1;371:110342. doi: 10.1016/j.cbi.2023.110342. Epub 2023 Jan 10.
192 Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
193 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
194 JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
195 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
196 Gene expression profiling of early primary biliary cirrhosis: possible insights into the mechanism of action of ursodeoxycholic acid. Liver Int. 2008 Aug;28(7):997-1010. doi: 10.1111/j.1478-3231.2008.01744.x. Epub 2008 Apr 15.
197 Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
198 Interactive gene expression pattern in prostate cancer cells exposed to phenolic antioxidants. Life Sci. 2002 Mar 1;70(15):1821-39.
199 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
200 Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
201 Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
202 Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
203 [Quercetin affects leptin and its receptor in human gastric cancer MGC-803 cells and JAK-STAT pathway]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 Jan;28(1):12-6.
204 Regulation of leptin receptor expression in human papillary thyroid cancer cells. Biomed Pharmacother. 2012 Sep;66(6):469-73. doi: 10.1016/j.biopha.2012.03.008. Epub 2012 Mar 31.
205 Lipoxin A4 methyl ester attenuated ketamine-induced neurotoxicity in SH-SY5Y cells via regulating leptin pathway. Toxicol In Vitro. 2023 Jun;89:105581. doi: 10.1016/j.tiv.2023.105581. Epub 2023 Mar 11.
206 Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
207 Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
208 Retinoic acid regulates the expression of photoreceptor transcription factor NRL. J Biol Chem. 2006 Sep 15;281(37):27327-34. doi: 10.1074/jbc.M605500200. Epub 2006 Jul 19.
209 Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
210 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
211 Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
212 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
213 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
214 Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
215 Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan;92(1):469-485.
216 Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. Mol Cancer. 2006 May 18;5:20. doi: 10.1186/1476-4598-5-20.
217 Changes in gene expressions elicited by physiological concentrations of genistein on human endometrial cancer cells. Mol Carcinog. 2006 Oct;45(10):752-63.
218 The antiproliferative effects of progestins in T47D breast cancer cells are tempered by progestin induction of the ETS transcription factor Elf5. Mol Endocrinol. 2010 Jul;24(7):1380-92. doi: 10.1210/me.2009-0516. Epub 2010 Jun 2.
219 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
220 Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
221 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
222 Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
223 Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
224 Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
225 Identification of transcriptional biomarkers induced by SERMS in human endometrial cells using multivariate analysis of DNA microarrays. Biomarkers. 2004 Nov-Dec;9(6):447-60.
226 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
227 Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). Toxicol Sci. 2013 Dec;136(2):328-43.
228 Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
229 Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals. Chem Res Toxicol. 2017 May 15;30(5):1219-1229. doi: 10.1021/acs.chemrestox.7b00048. Epub 2017 May 4.
230 A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicol Sci. 2013 Nov;136(1):216-41.
231 Blood cell oxidative stress precedes hemolysis in whole blood-liver slice co-cultures of rat, dog, and human tissues. Toxicol Appl Pharmacol. 2010 May 1;244(3):354-65. doi: 10.1016/j.taap.2010.01.017. Epub 2010 Feb 6.
232 Indomethacin inhibits cell growth of medullary thyroid carcinoma by reducing cell cycle progression into S phase. Exp Biol Med (Maywood). 2008 Nov;233(11):1433-40. doi: 10.3181/0804-RM-127. Epub 2008 Sep 12.
233 Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer. Endocr Relat Cancer. 2011 Apr 28;18(3):333-45. doi: 10.1530/ERC-10-0262. Print 2011 Jun.
234 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
235 Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
236 Sulindac induces specific degradation of the HPV oncoprotein E7 and causes growth arrest and apoptosis in cervical carcinoma cells. Cancer Lett. 2007 Jan 8;245(1-2):103-11. doi: 10.1016/j.canlet.2005.12.034. Epub 2006 Feb 20.
237 Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance. Exp Cell Res. 2012 Jun 10;318(10):1146-59.
238 HMG-CoA reductase inhibitor simvastatin inhibits cell cycle progression at the G1/S checkpoint in immortalized lymphocytes from Alzheimer's disease patients independently of cholesterol-lowering effects. J Pharmacol Exp Ther. 2008 Jan;324(1):352-9. doi: 10.1124/jpet.107.128959. Epub 2007 Oct 10.
239 Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
240 Troglitazone suppresses cell growth of KU812 cells independently of PPARgamma. Eur J Pharmacol. 2002 Feb 1;436(1-2):7-13. doi: 10.1016/s0014-2999(01)01577-1.
241 Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. Int J Mol Sci. 2016 Dec 23;18(1):26. doi: 10.3390/ijms18010026.
242 The protective effects of liraglutide on AD-like neurodegeneration induced by oxidative stress in human neuroblastoma SH-SY5Y cells. Chem Biol Interact. 2019 Sep 1;310:108688. doi: 10.1016/j.cbi.2019.06.001. Epub 2019 Jun 4.
243 Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis. Oncogene. 2001 Sep 27;20(43):6250-7. doi: 10.1038/sj.onc.1204791.
244 Differential effects of simvastatin and pravastatin on expression of Alzheimer's disease-related genes in human astrocytes and neuronal cells. J Lipid Res. 2009 Oct;50(10):2095-102. doi: 10.1194/jlr.M900236-JLR200. Epub 2009 May 21.
245 Suppression of NF-kappaB and GSK-3beta is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone. Chem Biol Interact. 2010 Oct 6;188(1):75-85. doi: 10.1016/j.cbi.2010.06.001. Epub 2010 Jun 9.
246 NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. J Biol Chem. 2021 Jan-Jun;296:100624. doi: 10.1016/j.jbc.2021.100624. Epub 2021 Apr 2.
247 Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
248 In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells. Food Chem Toxicol. 2022 Jan;159:112722. doi: 10.1016/j.fct.2021.112722. Epub 2021 Dec 3.
249 Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
250 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
251 Involvement of the p38 MAPK signaling pathway in S-phase cell-cycle arrest induced by Furazolidone in human hepatoma G2 cells. J Appl Toxicol. 2013 Dec;33(12):1500-5. doi: 10.1002/jat.2829. Epub 2012 Oct 30.
252 Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia. J Cell Mol Med. 2018 Mar;22(3):1614-1626.
253 Effect of ellagic acid on the expression of human telomerase reverse transcriptase (hTERT) alpha+beta+ transcript in estrogen receptor-positive MCF-7 breast cancer cells. Clin Biochem. 2009 Sep;42(13-14):1358-62. doi: 10.1016/j.clinbiochem.2009.05.017. Epub 2009 Jun 6.
254 Inhibitory effects of selenium on telomerase activity and hTERT expression in cadmium-transformed 16HBE cells. Biomed Environ Sci. 2007 Aug;20(4):307-12.
255 Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast cancer cells. BMC Cancer. 2010 Jul 22;10:390. doi: 10.1186/1471-2407-10-390.
256 Analysis of telomerase activity and RNA expression in a patient with acute promyelocytic leukemia treated with all-trans retinoic acid. Pediatr Blood Cancer. 2006 Apr;46(4):506-11. doi: 10.1002/pbc.20392.
257 Characterization of the functional and growth properties of long-term cell cultures established from a human somatostatinoma. Endocr Relat Cancer. 2006 Mar;13(1):79-93. doi: 10.1677/erc.1.00988.
258 Characterization of arsenic-induced cytogenetic alterations in acute promyelocytic leukemia cell line, NB4. Med Oncol. 2012 Jun;29(2):1209-16. doi: 10.1007/s12032-011-9946-4. Epub 2011 May 5.
259 Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
260 mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
261 Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
262 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
263 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
264 Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin. Invest New Drugs. 2011 Oct;29(5):945-52. doi: 10.1007/s10637-010-9450-2. Epub 2010 May 13.
265 Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene. 2005 Sep 15;24(41):6213-21. doi: 10.1038/sj.onc.1208774.
266 Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest. 2009 Jul;27(6):604-12. doi: 10.1080/07357900802337191.
267 Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. Apoptosis. 2006 Sep;11(9):1503-12. doi: 10.1007/s10495-006-8896-3.
268 CyclinB2 and BIRC5 genes as surrogate biomarkers for neurite outgrowth in SH-SY5Y subclonal cells. Neuropharmacology. 2006 Jun;50(8):1041-7. doi: 10.1016/j.neuropharm.2006.02.004. Epub 2006 Mar 30.
269 Time course study of A formation and neurite outgrowth disruption in differentiated human neuroblastoma cells exposed to H2O2: protective role of autophagy. Toxicol In Vitro. 2013 Sep;27(6):1780-8. doi: 10.1016/j.tiv.2013.05.005. Epub 2013 May 29.
270 Multitarget effects of quercetin in leukemia. Cancer Prev Res (Phila). 2014 Dec;7(12):1240-50. doi: 10.1158/1940-6207.CAPR-13-0383. Epub 2014 Oct 7.
271 Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
272 Arsenic trioxide induces autophagic cell death in osteosarcoma cells via the ROS-TFEB signaling pathway. Biochem Biophys Res Commun. 2018 Jan 29;496(1):167-175. doi: 10.1016/j.bbrc.2018.01.018. Epub 2018 Jan 4.
273 Effects of SIDT2 on the miR-25/NOX4/HuR axis and SIRT3 mRNA stability lead to ROS-mediated TNF- expression in hydroquinone-treated leukemia cells. Cell Biol Toxicol. 2023 Oct;39(5):2207-2225. doi: 10.1007/s10565-022-09705-5. Epub 2022 Mar 18.
274 AMPK activation induced by promethazine increases NOXA expression and Beclin-1 phosphorylation and drives autophagy-associated apoptosis in chronic myeloid leukemia. Chem Biol Interact. 2020 Jan 5;315:108888. doi: 10.1016/j.cbi.2019.108888. Epub 2019 Nov 2.
275 Endoplasmic reticulum stress contributes to autophagy and apoptosis in cantharidin-induced nephrotoxicity. Food Chem Toxicol. 2022 May;163:112986. doi: 10.1016/j.fct.2022.112986. Epub 2022 Apr 6.
276 Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-kappaB activity. Toxicol Sci. 2002 Apr;66(2):233-43. doi: 10.1093/toxsci/66.2.233.
277 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
278 Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
279 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
280 Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. Cancer Res. 2002 Nov 1;62(21):6006-10.
281 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
282 Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells. J Biochem Mol Toxicol. 2020 Feb;34(2):e22433. doi: 10.1002/jbt.22433. Epub 2020 Jan 9.
283 A cell impedance-based real-time in vitro assay to assess the toxicity of amphotericin B formulations. Toxicol Appl Pharmacol. 2017 Nov 1;334:18-23. doi: 10.1016/j.taap.2017.08.017. Epub 2017 Sep 1.
284 CBD Promotes Oral Ulcer Healing via Inhibiting CMPK2-Mediated Inflammasome. J Dent Res. 2022 Feb;101(2):206-215. doi: 10.1177/00220345211024528. Epub 2021 Jul 16.
285 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
286 Anti-inflammatory effects of the GABA(B) receptor agonist baclofen in allergic contact dermatitis. Exp Dermatol. 2010 Jul 1;19(7):661-6. doi: 10.1111/j.1600-0625.2010.01076.x. Epub 2010 Feb 25.
287 Sulfasalazine unveils a contact-independent HSV-TK/ganciclovir gene therapy bystander effect in malignant gliomas. Int J Oncol. 2007 Jan;30(1):283-90.
288 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
289 Regulatory role of nitric oxide on monocyte-derived dendritic cell functions. J Interferon Cytokine Res. 2003 Aug;23(8):423-31. doi: 10.1089/107999003322277838.
290 ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
291 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
292 Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
293 (9)-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7-Stimulated Human Coculture. J Pharmacol Exp Ther. 2019 Oct;371(1):191-201. doi: 10.1124/jpet.119.260661. Epub 2019 Aug 5.
294 Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
295 Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. Arch Toxicol. 2018 Jun;92(6):2043-2054. doi: 10.1007/s00204-018-2199-7. Epub 2018 Mar 29.
296 Spironolactone induces apoptosis in human mononuclear cells. Association between apoptosis and cytokine suppression. Apoptosis. 2006 Apr;11(4):573-9. doi: 10.1007/s10495-006-4919-3.
297 Some non-sensitizers upregulate CD54 expression by activation of the NLRP3 inflammasome in THP-1 cells. J Toxicol Sci. 2019;44(3):213-224. doi: 10.2131/jts.44.213.
298 Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
299 Sulfur mustard alkylates steroid hormones and impacts hormone function in vitro. Arch Toxicol. 2019 Nov;93(11):3141-3152. doi: 10.1007/s00204-019-02571-x. Epub 2019 Sep 12.
300 Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
301 Estrogen-like activity of metals in MCF-7 breast cancer cells. Endocrinology. 2003 Jun;144(6):2425-36. doi: 10.1210/en.2002-221054.
302 Cross-talk between non-genomic and genomic signalling pathways--distinct effect profiles of environmental estrogens. Toxicol Appl Pharmacol. 2010 Jun 1;245(2):160-70. doi: 10.1016/j.taap.2010.02.015. Epub 2010 Mar 4.
303 Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry. Odontology. 2013 Jan;101(1):43-51.
304 Antitumoral activity of liraglutide, a new DNMT inhibitor in breast cancer cells in vitro and in vivo. Chem Biol Interact. 2021 Nov 1;349:109641. doi: 10.1016/j.cbi.2021.109641. Epub 2021 Sep 14.
305 Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells. Mol Pharmacol. 2001 Sep;60(3):595-602.
306 Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth. Br J Cancer. 2007 Apr 23;96(8):1204-15. doi: 10.1038/sj.bjc.6603705. Epub 2007 Mar 27.
307 Prediction of the combined effects of multiple estrogenic chemicals on MCF-7 human breast cancer cells and a preliminary molecular exploration of the estrogenic proliferative effects and related gene expression. Ecotoxicol Environ Saf. 2018 Sep 30;160:1-9. doi: 10.1016/j.ecoenv.2018.05.025. Epub 2018 May 21.
308 [Arsenic trioxide restores ER expression in ER-negative human breast cancer cells and its treatment efficacy in combination with tamoxifen in xenografts in nude mice]. Zhonghua Zhong Liu Za Zhi. 2012 Sep;34(9):645-51. doi: 10.3760/cma.j.issn.0253-3766.2012.09.002.
309 Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
310 Down-regulation of HER-2 expression in human breast cancer cell HBC-4 and ZR75-1 by nitrogen-mustard-N-oxide. Kobe J Med Sci. 2007;53(4):135-42.
311 Aspirin inhibits ErbB2 to induce apoptosis in cervical cancer cells. Med Oncol. 2010 Jun;27(2):379-87. doi: 10.1007/s12032-009-9221-0. Epub 2009 May 8.
312 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
313 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
314 Inter- and intra-laboratory study to determine the reproducibility of toxicogenomics datasets. Toxicology. 2011 Nov 28;290(1):50-8.
315 Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
316 Arsenic trioxide (As(2)O(3)) induced apoptosis and its mechanisms in a human esophageal squamous carcinoma cell line. Chin Med J (Engl). 2002 Feb;115(2):280-5.
317 Simvastatin induces heat shock factor 1 in vascular endothelial cells. Atherosclerosis. 2006 Oct;188(2):265-73. doi: 10.1016/j.atherosclerosis.2005.10.045. Epub 2005 Dec 20.
318 Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
319 Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
320 Estrogen utilization of IGF-1-R and EGF-R to signal in breast cancer cells. J Steroid Biochem Mol Biol. 2010 Feb 28;118(4-5):219-30. doi: 10.1016/j.jsbmb.2009.09.018. Epub 2009 Oct 6.
321 Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
322 Simvastatin inhibits the proliferation of human prostate cancer PC-3 cells via down-regulation of the insulin-like growth factor 1 receptor. Biochem Biophys Res Commun. 2008 Jul 25;372(2):356-61. doi: 10.1016/j.bbrc.2008.05.043. Epub 2008 May 19.
323 Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
324 Arsenic trioxide and cisplatin synergism increase cytotoxicity in human ovarian cancer cells: therapeutic potential for ovarian cancer. Cancer Sci. 2009 Dec;100(12):2459-64.
325 Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
326 Activation of inflammasomes by tyrosine kinase inhibitors of vascular endothelial growth factor receptor: Implications for VEGFR TKIs-induced immune related adverse events. Toxicol In Vitro. 2021 Mar;71:105063. doi: 10.1016/j.tiv.2020.105063. Epub 2020 Dec 1.
327 Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
328 Dihydroartemisinin induces pyroptosis by promoting the AIM2/caspase-3/DFNA5 axis in breast cancer cells. Chem Biol Interact. 2021 May 1;340:109434. doi: 10.1016/j.cbi.2021.109434. Epub 2021 Mar 6.
329 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
330 Cigarette smoke and asbestos activate poly-ADP-ribose polymerase in alveolar epithelial cells. J Investig Med. 2001 Jan;49(1):68-76. doi: 10.2310/6650.2001.34092.
331 The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. doi: 10.1002/(sici)1099-0461(1999)13:6<338::aid-jbt8>3.0.co;2-7.
332 Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
333 Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
334 Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
335 Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells. Clin Exp Immunol. 2007 May;148(2):288-95. doi: 10.1111/j.1365-2249.2007.03335.x. Epub 2007 Feb 7.
336 Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c. Biochim Biophys Acta. 2010 Apr;1803(4):452-67. doi: 10.1016/j.bbamcr.2009.12.005. Epub 2010 Jan 4.
337 Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. Pharmacogenet Genomics. 2006 Apr;16(4):287-96. doi: 10.1097/01.fpc.0000189800.88596.7a.
338 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
339 Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
340 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
341 Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
342 Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
343 Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
344 Dimethyl Fumarate Inhibits the Nuclear Factor B Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. J Biol Chem. 2016 Feb 12;291(7):3639-47. doi: 10.1074/jbc.M115.679704. Epub 2015 Dec 18.
345 Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients. Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1194-9. doi: 10.1161/01.atv.0000022694.16328.cc.
346 Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFB and AhR and EGFR-ERK pathway. Toxicol Appl Pharmacol. 2011 Sep 1;255(2):138-49.
347 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
348 Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment. Pharmaceutics. 2021 Sep 7;13(9):1415. doi: 10.3390/pharmaceutics13091415.
349 Pentosan polysulfate decreases proliferation and extracellular matrix deposition by vascular smooth muscle cells isolated from failed hemodialysis access grafts. Clin Nephrol. 2000 Aug;54(2):121-7.
350 Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
351 Matrix metalloproteinase-9 is involved in chronic lymphocytic leukemia cell response to fludarabine and arsenic trioxide. PLoS One. 2014 Jun 23;9(6):e99993. doi: 10.1371/journal.pone.0099993. eCollection 2014.
352 Simvastatin, an HMG-CoA reductase inhibitor, reduced the expression of matrix metalloproteinase-9 (Gelatinase B) in osteoblastic cells and HT1080 fibrosarcoma cells. J Pharmacol Sci. 2004 Apr;94(4):403-9. doi: 10.1254/jphs.94.403.
353 Antifibrotic effects of quercetin in primary orbital fibroblasts and orbital fat tissue cultures of Graves' orbitopathy. Invest Ophthalmol Vis Sci. 2012 Aug 31;53(9):5921-9. doi: 10.1167/iovs.12-9646.
354 Relationship between release of platelet/endothelial biomarkers and plasma levels of sertraline and N-desmethylsertraline in acute coronary syndrome patients receiving SSRI treatment for depression. Am J Psychiatry. 2005 Jun;162(6):1165-70. doi: 10.1176/appi.ajp.162.6.1165.
355 Low dosage of arsenic trioxide (As(2)O(3)) inhibits angiogenesis in epithelial ovarian cancer without cell apoptosis. J Biol Inorg Chem. 2018 Aug;23(6):939-947. doi: 10.1007/s00775-018-1595-z. Epub 2018 Jul 16.
356 Effects of aspirin on metastasis-associated gene expression detected by cDNA microarray. Acta Pharmacol Sin. 2004 Oct;25(10):1327-33.
357 Thalidomide suppresses angiogenesis and immune evasion via lncRNA FGD5-AS1/miR-454-3p/ZEB1 axis-mediated VEGFA expression and PD-1/PD-L1 checkpoint in NSCLC. Chem Biol Interact. 2021 Nov 1;349:109652. doi: 10.1016/j.cbi.2021.109652. Epub 2021 Sep 11.
358 RhoA/MLC signaling pathway is involved in ?-tetrahydrocannabinol-impaired placental angiogenesis. Toxicol Lett. 2018 Mar 15;285:148-155. doi: 10.1016/j.toxlet.2017.12.031. Epub 2018 Jan 4.
359 Magnitude and time course of platelet inhibition with Aggrenox and Aspirin in patients after ischemic stroke: the AGgrenox versus Aspirin Therapy Evaluation (AGATE) trial. Eur J Pharmacol. 2004 Sep 24;499(3):315-24. doi: 10.1016/j.ejphar.2004.07.114.
360 Possible roles for folic acid in the regulation of trophoblast invasion and placental development in normal early human pregnancy. Biol Reprod. 2011 Jun;84(6):1148-53. doi: 10.1095/biolreprod.110.088351. Epub 2011 Feb 23.
361 Rosiglitazone impairs proliferation of human adrenocortical cancer: preclinical study in a xenograft mouse model. Endocr Relat Cancer. 2010 Feb 18;17(1):169-77. doi: 10.1677/ERC-09-0170. Print 2010 Mar.
362 Effects of niacin on cell adhesion and early atherogenesis: biochemical and functional findings in endothelial cells. Basic Clin Pharmacol Toxicol. 2009 Mar;104(3):206-10. doi: 10.1111/j.1742-7843.2008.00364.x. Epub 2009 Jan 21.
363 Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone. Blood. 2004 Apr 15;103(8):3138-47. doi: 10.1182/blood-2003-05-1543. Epub 2003 Dec 24.
364 Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein. Autophagy. 2021 Oct;17(10):2783-2799. doi: 10.1080/15548627.2020.1841953. Epub 2020 Nov 9.
365 Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
366 Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.
367 SU5416 inhibited VEGF and HIF-1alpha expression through the PI3K/AKT/p70S6K1 signaling pathway. Biochem Biophys Res Commun. 2004 Nov 12;324(2):471-80. doi: 10.1016/j.bbrc.2004.09.082.
368 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
369 D-glucosamine down-regulates HIF-1alpha through inhibition of protein translation in DU145 prostate cancer cells. Biochem Biophys Res Commun. 2009 Apr 24;382(1):96-101. doi: 10.1016/j.bbrc.2009.02.129. Epub 2009 Feb 28.
370 Arsenic trioxide inhibits translation of mRNA of bcr-abl, resulting in attenuation of Bcr-Abl levels and apoptosis of human leukemia cells. Cancer Res. 2003 Nov 15;63(22):7950-8.
371 Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs. Cell Cycle. 2010 Apr 15;9(8):1629-38. doi: 10.4161/cc.9.8.11487. Epub 2010 Apr 15.
372 Quercetin protected against isoniazide-induced HepG2 cell apoptosis by activating the SIRT1/ERK pathway. J Biochem Mol Toxicol. 2019 Sep;33(9):e22369. doi: 10.1002/jbt.22369. Epub 2019 Jul 23.
373 Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1/GSTA1 expression via JNK signaling pathway. J Appl Toxicol. 2021 Dec;41(12):2011-2020. doi: 10.1002/jat.4181. Epub 2021 May 6.
374 A Study of Gentianae Radix et Rhizoma Class Differences Based on Chemical Composition and Core Efficacy. Molecules. 2023 Oct 17;28(20):7132. doi: 10.3390/molecules28207132.
375 Rifampicin-induced injury in L02 cells is alleviated by 4-PBA via inhibition of the PERK-ATF4-CHOP pathway. Toxicol In Vitro. 2016 Oct;36:186-196. doi: 10.1016/j.tiv.2016.07.017. Epub 2016 Jul 26.
376 The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling. Oncogene. 2001 Feb 1;20(5):645-53. doi: 10.1038/sj.onc.1204123.
377 Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines. Breast. 2018 Oct;41:34-41. doi: 10.1016/j.breast.2018.06.009. Epub 2018 Jun 22.
378 -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
379 Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. Eur Rev Med Pharmacol Sci. 2016;20(6):1203-13.
380 Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells. J Pharmacol Exp Ther. 2001 Sep;298(3):976-85.
381 Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line. Mol Cancer Ther. 2009 May;8(5):1197-206.
382 Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
383 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
384 Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3767-77.
385 Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells. Lipids Health Dis. 2010 Jun 2;9:56. doi: 10.1186/1476-511X-9-56.
386 Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
387 Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
388 Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
389 Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer. 2006 Mar 15;118(6):1370-80. doi: 10.1002/ijc.21537.
390 Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
391 Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1. J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. doi: 10.1124/jpet.104.071332. Epub 2004 Jul 19.
392 Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. Int Arch Allergy Immunol. 2011;155(1):38-51. doi: 10.1159/000318720. Epub 2010 Nov 25.
393 SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
394 Imiquimod induces apoptosis of human melanocytes. Arch Dermatol Res. 2010 May;302(4):301-6. doi: 10.1007/s00403-009-1012-0. Epub 2009 Dec 23.
395 Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
396 A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
397 The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
398 Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
399 Cannabidiol Protects Human Skin Keratinocytes from Hydrogen-Peroxide-Induced Oxidative Stress via Modulation of the Caspase-1-IL-1 Axis. J Nat Prod. 2021 May 28;84(5):1563-1572. doi: 10.1021/acs.jnatprod.1c00083. Epub 2021 May 6.
400 Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
401 Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment. J Pharmacol Exp Ther. 2014 Mar;348(3):360-71. doi: 10.1124/jpet.113.210054. Epub 2013 Dec 17.
402 Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes. Toxicol Lett. 2023 Mar 1;376:39-50. doi: 10.1016/j.toxlet.2023.01.005. Epub 2023 Jan 13.
403 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
404 Thiazolidinediones inhibit proliferation of microvascular and macrovascular cells by a PPARgamma-independent mechanism. Diabetologia. 2005 Mar;48(3):586-94. doi: 10.1007/s00125-005-1672-z. Epub 2005 Feb 24.
405 Retinoid targeting of different D-type cyclins through distinct chemopreventive mechanisms. Cancer Res. 2005 Jul 15;65(14):6476-83. doi: 10.1158/0008-5472.CAN-05-0370.
406 A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3378-83.
407 Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
408 Effect of nephrotoxicants and hepatotoxicants on gene expression profile in human peripheral blood mononuclear cells. Biochem Biophys Res Commun. 2010 Oct 15;401(2):245-50. doi: 10.1016/j.bbrc.2010.09.039. Epub 2010 Sep 16.
409 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
410 Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
411 Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
412 Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. Mol Cancer. 2010 Aug 20;9:220.
413 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
414 Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2015 Mar;35(3):1063-76. doi: 10.1111/liv.12626. Epub 2014 Jul 30.
415 Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
416 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
417 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
418 Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
419 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
420 p21(WAF1/cip1) is an important determinant of intestinal cell response to sulindac in vitro and in vivo. Cancer Res. 2001 Aug 15;61(16):6297-302.
421 eIF4E is a critical regulator of human papillomavirus (HPV)-immortalized cervical epithelial (H8) cell growth induced by nicotine. Toxicology. 2019 May 1;419:1-10. doi: 10.1016/j.tox.2019.02.017. Epub 2019 Mar 2.
422 Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
423 Repression of Kisspeptin1 weakens hydrogen peroxide-caused injury in HTR8 cells via adjusting PI3K/AKT/mTOR pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22461. doi: 10.1002/jbt.22461. Epub 2020 Feb 11.
424 Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals. Toxicol Lett. 2022 Feb 1;355:1-18. doi: 10.1016/j.toxlet.2021.10.013. Epub 2021 Nov 5.
425 Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways. PLoS One. 2012;7(10):e47516. doi: 10.1371/journal.pone.0047516. Epub 2012 Oct 18.
426 A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
427 Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR. Environ Toxicol. 2023 Aug;38(8):1874-1890. doi: 10.1002/tox.23814. Epub 2023 May 6.
428 Constitutive gene expression predisposes morphogen-mediated cell fate responses of NT2/D1 and 27X-1 human embryonal carcinoma cells. Stem Cells. 2007 Mar;25(3):771-8. doi: 10.1634/stemcells.2006-0271. Epub 2006 Nov 30.
429 Arsenic trioxide inhibits P-glycoprotein expression in multidrug-resistant human leukemia K562/ADM cell line that overexpresses mdr-1 gene and enhances their chemotherapeutic sensitivity. Zhonghua Xue Ye Xue Za Zhi. 2003 Jan;24(1):28-31.
430 Cantharidin suppresses gastric cancer cell migration/invasion by inhibiting the PI3K/Akt signaling pathway via CCAT1. Chem Biol Interact. 2020 Feb 1;317:108939. doi: 10.1016/j.cbi.2020.108939. Epub 2020 Jan 13.
431 Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway. Free Radic Biol Med. 2019 Feb 1;131:225-236. doi: 10.1016/j.freeradbiomed.2018.12.008. Epub 2018 Dec 11.
432 Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
433 Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
434 Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem. 2002 Nov 15;277(46):43648-58. doi: 10.1074/jbc.M203214200. Epub 2002 Sep 6.
435 Lon protease and eiF2 are involved in acute, but not prolonged, antiretroviral induced stress response in HepG2 cells. Chem Biol Interact. 2016 May 25;252:82-6. doi: 10.1016/j.cbi.2016.03.021. Epub 2016 Apr 1.
436 Disease-modifying effects of glucosamine HCl involving regulation of metalloproteinases and chemokines activated by interleukin-1beta in human primary synovial fibroblasts. J Cell Biochem. 2008 May 1;104(1):38-50. doi: 10.1002/jcb.21597.
437 Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine. Cancer Sci. 2003 Oct;94(10):886-93.
438 Apoptosis induced by arsenic trioxide in leukemia U937 cells is dependent on activation of p38, inactivation of ERK and the Ca2+-dependent production of superoxide. Int J Cancer. 2001 May 15;92(4):518-26. doi: 10.1002/ijc.1220.
439 Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Arthritis Rheum. 2012 Jun;64(6):1780-9. doi: 10.1002/art.34342. Epub 2011 Dec 19.
440 Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. Melanoma Res. 2008 Apr;18(2):85-94. doi: 10.1097/CMR.0b013e3282f60097.
441 Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. Biochem Pharmacol. 2001 May 15;61(10):1205-15. doi: 10.1016/s0006-2952(01)00583-4.
442 Fluoxetine mediates G0/G1 arrest by inducing functional inhibition of cyclin dependent kinase subunit (CKS)1. Biochem Pharmacol. 2008 May 15;75(10):1924-34. doi: 10.1016/j.bcp.2008.02.013. Epub 2008 Feb 17.
443 Induction mechanism of apoptosis by troglitazone through peroxisome proliferator-activated receptor-gamma in gastric carcinoma cells. Anticancer Res. 2003 Jan-Feb;23(1A):267-73.
444 Down-regulation of CD44 contributes to the differentiation of HL-60 cells induced by ATRA or HMBA. Cell Mol Immunol. 2007 Feb;4(1):59-63.
445 NF-B potentiates caspase independent hydrogen peroxide induced cell death. PLoS One. 2011 Feb 15;6(2):e16815. doi: 10.1371/journal.pone.0016815.
446 Carvedilol prevents epinephrine-induced apoptosis in human coronary artery endothelial cells: modulation of Fas/Fas ligand and caspase-3 pathway. Cardiovasc Res. 2000 Feb;45(3):788-94. doi: 10.1016/s0008-6363(99)00369-7.
447 Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells. Oncol Rep. 2011 Feb;25(2):583-91. doi: 10.3892/or.2010.1097. Epub 2010 Dec 10.
448 Non-nutritional sweeteners effects on endothelial vascular function. Toxicol In Vitro. 2020 Feb;62:104694. doi: 10.1016/j.tiv.2019.104694. Epub 2019 Oct 23.
449 Influence of antitumor drugs on the expression of Fas system in SW480 colon cancer cells. Eur J Gastroenterol Hepatol. 2006 Oct;18(10):1071-7. doi: 10.1097/01.meg.0000231750.68513.6c.
450 Acrolein enhances epigenetic modifications, FasL expression and hepatocyte toxicity induced by anti-HIV drug Zidovudine. Toxicol In Vitro. 2016 Sep;35:66-76. doi: 10.1016/j.tiv.2016.05.013. Epub 2016 May 26.
451 Rifampicin inhibits CD95-mediated apoptosis of Jurkat T cells via glucocorticoid receptors by modifying the expression of molecules regulating apoptosis. J Clin Immunol. 2002 Jan;22(1):37-47. doi: 10.1023/a:1014256603539.
452 Inhibition of drug-induced Fas ligand transcription and apoptosis by Bcl-XL. Mol Cell Biochem. 2001 Sep;225(1-):7-20. doi: 10.1023/a:1012203110027.
453 Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1. Mol Endocrinol. 2010 May;24(5):969-80. doi: 10.1210/me.2009-0148. Epub 2010 Mar 8.
454 Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
455 K-RAS transformation in prostate epithelial cell overcomes H2O2-induced apoptosis via upregulation of gamma-glutamyltransferase-2. Toxicol In Vitro. 2012 Apr;26(3):429-34. doi: 10.1016/j.tiv.2012.01.013. Epub 2012 Jan 17.
456 Nitric oxide inhibits execution of apoptosis at two distinct ATP-dependent steps upstream and downstream of mitochondrial cytochrome c release. Biochem Biophys Res Commun. 1999 Apr 29;258(1):215-21. doi: 10.1006/bbrc.1999.0491.
457 Troglitazone induces cytotoxicity in part by promoting the degradation of peroxisome proliferator-activated receptor co-activator-1 protein. Br J Pharmacol. 2010 Oct;161(4):771-81. doi: 10.1111/j.1476-5381.2010.00900.x.
458 Under ambient UVA exposure, pefloxacin exhibits both immunomodulatory and genotoxic effects via multiple mechanisms. J Photochem Photobiol B. 2018 Jan;178:593-605. doi: 10.1016/j.jphotobiol.2017.12.014. Epub 2017 Dec 15.
459 [Role of Bcl-xL in the cathepsin D-associated apoptosis of K562 cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2005 Jun;13(3):379-82.
460 Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor. Nat Med. 2004 Jan;10(1):40-7. doi: 10.1038/nm969. Epub 2003 Dec 14.
461 Estrogen receptor regulates E2F1 expression to mediate tamoxifen resistance. Mol Cancer Res. 2010 Mar;8(3):343-52. doi: 10.1158/1541-7786.MCR-09-0395. Epub 2010 Mar 9.
462 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
463 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
464 The protective effect of quercetin against oxidative stress in the human RPE in vitro. Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1712-20. doi: 10.1167/iovs.07-0477.
465 Nitric oxide regulates lung carcinoma cell anoikis through inhibition of ubiquitin-proteasomal degradation of caveolin-1. J Biol Chem. 2009 Oct 9;284(41):28476-28484. doi: 10.1074/jbc.M109.050864. Epub 2009 Aug 25.
466 Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
467 Harnessing autophagy to overcome mitogen-activated protein kinase kinase inhibitor-induced resistance in metastatic melanoma. Br J Dermatol. 2019 Feb;180(2):346-356. doi: 10.1111/bjd.17333. Epub 2018 Nov 25.
468 Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
469 A genomic approach to predict synergistic combinations for breast cancer treatment. Pharmacogenomics J. 2013 Feb;13(1):94-104. doi: 10.1038/tpj.2011.48. Epub 2011 Nov 15.
470 Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells. Carcinogenesis. 2005 May;26(5):883-91. doi: 10.1093/carcin/bgi036. Epub 2005 Feb 10.
471 Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis. Br J Cancer. 2011 Apr 12;104(8):1278-87. doi: 10.1038/bjc.2011.84.
472 Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells. Mol Cancer. 2011 Jul 31;10:95. doi: 10.1186/1476-4598-10-95.
473 Melatonin enhances hydrogen peroxide-induced apoptosis in human promyelocytic leukaemia HL-60 cells. Mol Cell Biochem. 2011 Jul;353(1-2):167-76. doi: 10.1007/s11010-011-0783-8. Epub 2011 Mar 23.
474 Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells. Br J Cancer. 2002 Feb 1;86(3):443-8. doi: 10.1038/sj.bjc.6600079.
475 Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
476 Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
477 Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
478 In vitro aromatic bioactivation of the weak estrogen E(2)alpha and genesis of DNA adducts. Steroids. 2005 Mar;70(3):161-72. doi: 10.1016/j.steroids.2004.11.004.
479 Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr;33(4):489-94.
480 Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1. Drug Metab Dispos. 2004 Aug;32(8):840-7.
481 Apoptosis contributes to the cytotoxicity induced by amodiaquine and its major metabolite N-desethylamodiaquine in hepatic cells. Toxicol In Vitro. 2020 Feb;62:104669. doi: 10.1016/j.tiv.2019.104669. Epub 2019 Oct 16.
482 Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. doi: 10.1158/0008-5472.CAN-07-6381.
483 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
484 Induction of NKG2D ligands and subsequent enhancement of NK cell-mediated lysis of cancer cells by arsenic trioxide. J Immunother. 2008 Jun;31(5):475-86. doi: 10.1097/CJI.0b013e3181755deb.
485 CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
486 Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells. Carcinogenesis. 2006 May;27(5):916-24. doi: 10.1093/carcin/bgi312. Epub 2005 Dec 16.
487 NF-kappa B regulates expression of the MHC class I-related chain A gene in activated T lymphocytes. J Immunol. 2004 Nov 1;173(9):5583-90. doi: 10.4049/jimmunol.173.9.5583.
488 Quercetin exerts bidirectional regulation effects on the efficacy of tamoxifen in estrogen receptor-positive breast cancer therapy: An in vitro study. Environ Toxicol. 2020 Nov;35(11):1179-1193. doi: 10.1002/tox.22983. Epub 2020 Jun 12.
489 Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens, phytoestrogens and xenoestrogens. Toxicology. 2001 Sep 14;166(1-2):79-89. doi: 10.1016/s0300-483x(01)00437-1.
490 Estrogenic effects of natural and synthetic compounds including tibolone assessed in Saccharomyces cerevisiae expressing the human estrogen alpha and beta receptors. FASEB J. 2006 Jul;20(9):1552-4. doi: 10.1096/fj.05-5413fje. Epub 2006 May 23.
491 Comparison of relative binding affinities to fish and mammalian estrogen receptors: the regulatory implications. Toxicol Lett. 2010 Feb 15;192(3):298-315. doi: 10.1016/j.toxlet.2009.11.004. Epub 2009 Nov 12.
492 Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ Health Perspect. 2004 Apr;112(5):524-31. doi: 10.1289/ehp.6649.
493 Valproic acid and its derivatives enhanced estrogenic activity but not androgenic activity in a structure dependent manner. Reprod Toxicol. 2013 Dec;42:49-57. doi: 10.1016/j.reprotox.2013.07.019. Epub 2013 Jul 26.
494 Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. Biosci Biotechnol Biochem. 2002 Jul;66(7):1479-87. doi: 10.1271/bbb.66.1479.
495 Arylpiperazines for management of benign prostatic hyperplasia: design, synthesis, quantitative structure-activity relationships, and pharmacokinetic studies. J Med Chem. 2011 Jan 13;54(1):302-11. doi: 10.1021/jm101163m. Epub 2010 Dec 3.
496 Inorganic arsenic exposure promotes malignant progression by HDAC6-mediated down-regulation of HTRA1. J Appl Toxicol. 2023 Aug;43(8):1214-1224. doi: 10.1002/jat.4457. Epub 2023 Mar 11.
497 Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
498 Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy. Oxid Med Cell Longev. 2018 Mar 18;2018:1482795. doi: 10.1155/2018/1482795. eCollection 2018.
499 TNF enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy. Toxicol Lett. 2021 May 15;342:73-84. doi: 10.1016/j.toxlet.2021.02.009. Epub 2021 Feb 17.
500 Inhibition of autophagy enhances Hydroquinone-induced TK6 cell death. Toxicol In Vitro. 2017 Jun;41:123-132. doi: 10.1016/j.tiv.2017.02.024. Epub 2017 Mar 2.
501 Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe. 2009 Sep 17;6(3):231-43. doi: 10.1016/j.chom.2009.08.004.
502 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
503 A high-throughput screen for teratogens using human pluripotent stem cells. Toxicol Sci. 2014 Jan;137(1):76-90. doi: 10.1093/toxsci/kft239. Epub 2013 Oct 23.
504 Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
505 Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
506 Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells. Oncotarget. 2016 Aug 9;7(32):52392-52403.
507 MARVELD1 attenuates arsenic trioxide-induced apoptosis in liver cancer cells by inhibiting reactive oxygen species production. Ann Transl Med. 2019 May;7(9):200. doi: 10.21037/atm.2019.04.38.
508 Cytotoxicity of simvastatin to pancreatic adenocarcinoma cells containing mutant ras gene. Jpn J Cancer Res. 1994 Jun;85(6):633-8. doi: 10.1111/j.1349-7006.1994.tb02406.x.
509 Regulation of the signal transduction program by drugs. Adv Enzyme Regul. 1997;37:35-55. doi: 10.1016/s0065-2571(96)00025-8.
510 Hydroquinone-induced malignant transformation of TK6 cells by facilitating SIRT1-mediated p53 degradation and up-regulating KRAS. Toxicol Lett. 2016 Sep 30;259:133-142. doi: 10.1016/j.toxlet.2016.08.006. Epub 2016 Aug 8.
511 Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells. Br J Haematol. 2005 Sep;130(6):912-25. doi: 10.1111/j.1365-2141.2005.05696.x.
512 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
513 The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
514 Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling. Free Radic Biol Med. 2012 Jul 1;53(1):44-50. doi: 10.1016/j.freeradbiomed.2012.04.031. Epub 2012 May 9.
515 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
516 Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42.
517 Anti-androgenic effect of 6-formylindolo[3,2-b]carbazole (FICZ) in LNCaP cells is mediated by the aryl hydrocarbon-androgen receptors cross-talk. Steroids. 2020 Jan;153:108508. doi: 10.1016/j.steroids.2019.108508. Epub 2019 Oct 3.
518 Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition. Arch Toxicol. 2008 Dec;82(12):909-21.
519 Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density. J Bone Miner Res. 2005 Feb;20(2):232-9. doi: 10.1359/JBMR.041110. Epub 2004 Nov 16.
520 Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 1999 Feb 1;59(3):607-14.
521 The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol. Arch Toxicol. 2013 Apr;87(4):633-43.
522 Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Gastroenterology. 2004 Nov;127(5):1436-45.
523 Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
524 Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
525 Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells. Biochem Biophys Res Commun. 2002 Feb 8;290(5):1427-33. doi: 10.1006/bbrc.2002.6367.
526 Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter. Free Radic Biol Med. 2002 Mar 1;32(5):386-93. doi: 10.1016/s0891-5849(01)00812-7.
527 Glycidamide and cis-2-butene-1,4-dial (BDA) as potential carcinogens and promoters of liver cancer - An in vitro study. Food Chem Toxicol. 2022 Aug;166:113251. doi: 10.1016/j.fct.2022.113251. Epub 2022 Jun 21.
528 Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
529 Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
530 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
531 Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer. Cancer Res. 2006 Mar 1;66(5):2765-77.
532 Estrogen-mediated inactivation of FOXO3a by the G protein-coupled estrogen receptor GPER. BMC Cancer. 2015 Oct 15;15:702. doi: 10.1186/s12885-015-1699-6.
533 Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization. Mol Endocrinol. 2006 Oct;20(10):2444-55. doi: 10.1210/me.2006-0118. Epub 2006 May 18.
534 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
535 An in vitro study on anti-carcinogenic effect of remdesivir in human ovarian cancer cells via generation of reactive oxygen species. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089257. doi: 10.1177/09603271221089257.
536 Involvement of mitochondrial dysfunction in nefazodone-induced hepatotoxicity. Food Chem Toxicol. 2016 Aug;94:148-58. doi: 10.1016/j.fct.2016.06.001. Epub 2016 Jun 8.
537 PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62.
538 Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
539 p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
540 Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
541 Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
542 Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
543 Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
544 Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. Nucleic Acids Res. 2009 Jan;37(1):78-95. doi: 10.1093/nar/gkn910. Epub 2008 Nov 16.
545 Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
546 Identification of TACC1, NOV, and PTTG1 as new candidate genes associated with endocrine therapy resistance in breast cancer. J Mol Endocrinol. 2009 Feb;42(2):87-103. doi: 10.1677/JME-08-0076. Epub 2008 Nov 4.
547 Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
548 Biological specificity of CDK4/6 inhibitors: dose response relationship, in vivo signaling, and composite response signature. Oncotarget. 2017 Jul 4;8(27):43678-43691. doi: 10.18632/oncotarget.18435.
549 Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo. J Invest Dermatol. 2006 Apr;126(4):732-9. doi: 10.1038/sj.jid.5700202.
550 Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
551 Amphiregulin is a vitamin D3 target gene in squamous cell and breast carcinoma. Biochem Biophys Res Commun. 2001 Mar 9;281(4):1051-6. doi: 10.1006/bbrc.2001.4466.
552 Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
553 Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer. Cancer Lett. 2006 Sep 8;241(1):93-101. doi: 10.1016/j.canlet.2005.10.014. Epub 2005 Dec 9.
554 Melatonin attenuates cisplatin-induced HepG2 cell death via the regulation of mTOR and ERCC1 expressions. World J Hepatol. 2014 Apr 27;6(4):230-42. doi: 10.4254/wjh.v6.i4.230.
555 Pemetrexed downregulates ERCC1 expression and enhances cytotoxicity effected by resveratrol in human nonsmall cell lung cancer cells. Naunyn Schmiedebergs Arch Pharmacol. 2013 Dec;386(12):1047-59. doi: 10.1007/s00210-013-0905-9. Epub 2013 Aug 3.
556 A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
557 Combination of oxaliplatin and irinotecan on human colon cancer cell lines: activity in vitro and in vivo. Anticancer Drugs. 2001 Oct;12(9):741-51. doi: 10.1097/00001813-200110000-00006.
558 Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates. Mol Cancer Ther. 2007 Mar;6(3):1031-8. doi: 10.1158/1535-7163.MCT-06-0643. Epub 2007 Mar 5.
559 Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
560 Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. doi: 10.1158/1535-7163.MCT-11-0934. Epub 2012 Jun 22.
561 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
562 Aspirin induces apoptosis in human leukemia cells independently of NF-kappaB and MAPKs through alteration of the Mcl-1/Noxa balance. Apoptosis. 2010 Feb;15(2):219-29. doi: 10.1007/s10495-009-0424-9.
563 Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines. Chem Biol Interact. 2010 Oct 6;188(1):214-9.
564 Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
565 Propolis alleviates 4-aminobiphenyl-induced oxidative DNA damage by inhibition of CYP2E1 expression in human liver cells. Environ Toxicol. 2021 Aug;36(8):1504-1513. doi: 10.1002/tox.23147. Epub 2021 Apr 13.
566 Unpredicted Downregulation of RAD51 Suggests Genome Instability Induced by Tetrachlorobenzoquinone. Chem Res Toxicol. 2016 Dec 19;29(12):2184-2193. doi: 10.1021/acs.chemrestox.6b00369. Epub 2016 Nov 21.
567 Molecular characterization of a toxicological tipping point during human stem cell differentiation. Reprod Toxicol. 2020 Jan;91:1-13. doi: 10.1016/j.reprotox.2019.10.001. Epub 2019 Oct 7.
568 Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3. Arch Toxicol. 2022 Jan;96(1):177-193. doi: 10.1007/s00204-021-03174-1. Epub 2021 Oct 19.
569 In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
570 Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
571 Gene expression analysis using human cancer xenografts to identify novel predictive marker genes for the efficacy of 5-fluorouracil-based drugs. Cancer Sci. 2006 Jun;97(6):510-22. doi: 10.1111/j.1349-7006.2006.00204.x.
572 Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
573 The psychoactive substance of cannabis 9-tetrahydrocannabinol (THC) negatively regulates CFTR in airway cells. Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):1988-1994. doi: 10.1016/j.bbagen.2018.06.008. Epub 2018 Jun 19.
574 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
575 Effects of paclitaxel on proliferation and apoptosis in human acute myeloid leukemia HL-60 cells. Acta Pharmacol Sin. 2004 Mar;25(3):378-84.
576 Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011 Feb 18;24(2):165-7. doi: 10.1021/tx1004419. Epub 2011 Feb 4.
577 Differential gene expression of sulindac-treated human breast epithelial cells. Int J Oncol. 2005 Dec;27(6):1727-36.
578 Prevention of deoxycholate-induced gastric apoptosis by aspirin: roles of NF-kappaB and PKC signaling. J Surg Res. 2008 Mar;145(1):66-73. doi: 10.1016/j.jss.2007.04.039. Epub 2007 Jul 20.
579 Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells. Immunology. 2007 May;121(1):71-81. doi: 10.1111/j.1365-2567.2006.02539.x.
580 Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells. Eur J Pharmacol. 2010 Jun 10;635(1-3):219-26. doi: 10.1016/j.ejphar.2010.02.044. Epub 2010 Mar 20.
581 Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism. Hepatology. 2017 Aug;66(2):432-448. doi: 10.1002/hep.29033. Epub 2017 Jun 16.
582 Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
583 14-3-3 regulation of and interaction with YAP1 in acquired gemcitabine resistance via promoting ribonucleotide reductase expression. Oncotarget. 2016 Apr 5;7(14):17726-36. doi: 10.18632/oncotarget.7394.
584 E2F1 downregulation by arsenic trioxide in lung adenocarcinoma. Int J Oncol. 2014 Nov;45(5):2033-43. doi: 10.3892/ijo.2014.2609. Epub 2014 Aug 19.
585 Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells. Mol Cancer Ther. 2012 Oct;11(10):2138-48. doi: 10.1158/1535-7163.MCT-12-0562. Epub 2012 Aug 6.