Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMI3491)

Drug Name
APIGENIN Drug Info
Synonyms
apigenin; 520-36-5; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; Chamomile; Versulin; Spigenin; Apigenol; 4',5,7-Trihydroxyflavone; Apigenine; C.I. Natural Yellow 1; 5,7,4'-Trihydroxyflavone; Pelargidenon 1449; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone; 2-(p-Hydroxyphenyl)-5,7-dihydroxychromone; UCCF 031; NSC 83244; UNII-7V515PI7F6; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one; CCRIS 3789; CHEBI:18388; CHEMBL28; EINECS 208-292-3; 4H-1-Benzopyran-4-one, 5,7-di
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5280443
ChEBI ID
CHEBI:18388
CAS Number
CAS 520-36-5
TTD Drug ID
DMI3491
VARIDT Drug ID
DR00822

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Patented Agent(s)
Investigative Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Plasmodium CDK Pfmrk (Malaria Pfmrk)
Drug Name Drug ID Indication ICD 11 Highest Status REF
KENPAULLONE DMAGVXW Discovery agent N.A. Patented [10]
2,5-dichloro-N-p-tolylthiophene-3-sulfonamide DMU5J8Y Discovery agent N.A. Investigative [18]
WR-289010 DMS2QUL Discovery agent N.A. Investigative [19]
WR-080539 DMUCGK8 Discovery agent N.A. Investigative [19]
5-chloro-4-nitrothiophene-2-sulfonamide DMRS82Q Discovery agent N.A. Investigative [18]
Oxindole derivative DM1AU8V Malaria 1F40-1F45 Investigative [20]
WR-203581 DM9M1UO Discovery agent N.A. Investigative [19]
WR-289009 DM5W9GR Discovery agent N.A. Investigative [19]
N-(2-aminoethyl)isoquinoline-5-sulfonamide DMG2MSX Discovery agent N.A. Investigative [21]
2-chloro-N-(o-tolylcarbamoyl)benzamide DMLDQ6I Discovery agent N.A. Investigative [18]
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Drug(s) Targeting Aromatase (CYP19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Anastrozole DMNP60F Breast cancer 2C60-2C65 Approved [22]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [23]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [23]
Aminoglutethimide DMWFHMZ Cushing disease 5A70 Approved [24]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [25]
Testolactone DMVY4GN Breast cancer 2C60-2C65 Approved [26]
LIAROZOLE DM4OYXE Dermatological disease DA24.Y Phase 2/3 [4]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [27]
BGS-649 DMO4MNQ Endometriosis GA10 Phase 2 [28]
NARINGENIN DMHAZLM N. A. N. A. Phase 1 [4]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [320]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [321]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [322]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [132]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [322]
Methotrexate DM2TEOL Anterior urethra cancer Approved [112]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [115]
Bifonazole DM3KN7V Fungal infection 1F29-1F2F Approved [323]
Quercetin DM3NC4M Obesity 5B81 Approved [324]
Fluoxetine DM3PD2C Bipolar depression Approved [322]
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Drug(s) Targeting Aldose reductase (AKR1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Epalrestat DM5OGK0 Diabetic neuropathy 8C0Z Approved [29]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [30]
Fidarestat DMZL1I8 Diabetic complication 5A2Y Phase 3 [31]
Ranirestat DMD5QRS Diabetic neuropathy 8C0Z Phase 3 [32]
CONTIGOSIDE B DMX9V8K Thrombosis DB61-GB90 Phase 2/3 [33]
BNV-222 DMYFQJL Diabetic neuropathy 8C0Z Phase 2/3 [32]
BNV-222 DMYFQJL Diabetic neuropathy 8C0Z Phase 2/3 [34]
LIDORESTAT DMA0RI9 Diabetic complication 5A2Y Phase 2 [35]
QR-333 DMKVIWM Diabetic neuropathy 8C0Z Phase 2 [36]
ADMVA DM819CO Diabetic complication 5A2Y Phase 2 [32]
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Drug(s) Targeting Influenza Neuraminidase (Influ NA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Oseltamivir DMGO72P Influenza 1E30-1E32 Approved [37]
Zanamivir DMFMBZ4 Influenza 1E30-1E32 Approved [37]
Peramivir DMNXY5K Influenza virus infection 1E30-1E32 Approved [38]
UX-001 DMD2O0L Hereditary inclusion body myositis 4A41.2 Phase 3 [39]
CS-8958 DM4CSDH Influenza virus infection 1E30-1E32 Phase 3 [38]
DAS-181 DM0Y8JP Influenza virus infection 1E30-1E32 Phase 2 [40]
Lactose DMO4GPK Discovery agent N.A. Phase 1 [39]
GS-3435 DMV7JC6 Influenza virus infection 1E30-1E32 Terminated [41]
BCX-140 DMBJERO Influenza virus infection 1E30-1E32 Terminated [42]
Alpha-D-Mannose DMF5DLW Discovery agent N.A. Investigative [39]
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Drug(s) Targeting Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
NARINGENIN DMHAZLM N. A. N. A. Phase 1 [8]
Nicotinamide-Adenine-Dinucleotide DM9LRKB N. A. N. A. Investigative [39]
2'-Monophosphoadenosine 5'-Diphosphoribose DME9S8M Discovery agent N.A. Investigative [39]
KAEMPFEROL DMHEMUB Discovery agent N.A. Investigative [8]
4-ANDROSTENE-3-17-DIONE DMSE8NU Discovery agent N.A. Investigative [39]
6-(3-Hydroxy-phenyl)-naphthalen-2-ol DMH8WA2 Discovery agent N.A. Investigative [43]
7-(3-Hydroxy-phenyl)-naphthalen-2-ol DM2I91C Discovery agent N.A. Investigative [44]
NSC-94258 DM6VY3P Discovery agent N.A. Investigative [8]
4-[5-(3-Hydroxyphenyl)-3-thienyl]-2-methylphenol DM7ERYJ Discovery agent N.A. Investigative [45]
6-(4-Hydroxy-phenyl)-naphthalen-1-ol DM2V9XI Discovery agent N.A. Investigative [44]
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Drug(s) Targeting Androgen receptor messenger RNA (AR mRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [46]
BAY 86-5044 DMRZLU4 Breast cancer 2C60-2C65 Phase 2 [47]
TRC-253 DMXI8CD Prostate cancer 2C82.0 Phase 1/2 [48]
IONIS-AR-2.5Rx DMF2DMS Prostate cancer 2C82.0 Phase 1/2 [49]
ISIS-AR DM8P3N5 Prostate cancer 2C82.0 Phase 1 [50]
EZN-4176 DMNPS59 Prostate cancer 2C82.0 Phase 1 [51]
EUGENOL DM7US1H Discovery agent N.A. Patented [52]
RU-58841 DMMEAZ2 Acne vulgaris ED80 Discontinued in Phase 1 [53]
flavone DMEQH6J Discovery agent N.A. Investigative [3]
KAEMPFEROL DMHEMUB Discovery agent N.A. Investigative [3]
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Drug(s) Targeting Casein kinase II alpha (CSNK2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
CX-4945 DMWE7B9 Coronavirus infection 1D92 Phase 2 [48]
BALANOL DMDLN9E N. A. N. A. Terminated [54]
EMODIN DMAEDQG Coronavirus Disease 2019 (COVID-19) 1D6Y Terminated [5]
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X Discovery agent N.A. Investigative [55]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB Discovery agent N.A. Investigative [5]
ELLAGIC ACID DMX8BS5 Discovery agent N.A. Investigative [5]
PMID24900749C1a DMZPUSO Discovery agent N.A. Investigative [56]
AdoC(Dpr)2AlaArg6 DM2TWSZ Discovery agent N.A. Investigative [57]
PMID22115617C2c DMX5UKA Discovery agent N.A. Investigative [58]
5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole DM3JB6S Discovery agent N.A. Investigative [5]
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Drug(s) Targeting Cyclin-dependent kinase 6 (CDK6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Apremilast DMTWS9E Psoriasis vulgaris EA90 Approved [59]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [60]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [61]
Ribociclib Succinate DM9CIUW Breast cancer 2C60-2C65 Approved [62]
Trilaciclib DMP5A4T Small-cell lung cancer 2C25.Y Approved [63]
LEE011 DMMX75K Breast cancer 2C60-2C65 Phase 3 [64]
G1T38 DMQO2IT Breast cancer 2C60-2C65 Phase 2 [48]
GLR2007 DM7DWLY Glioblastoma of brain 2A00.00 Phase 1/2 [65]
FCN-437 DMQ8VUW Breast cancer 2C60-2C65 Phase 1/2 [66]
NUV-422 DMQJQNT Malignant glioma 2A00.0 Phase 1/2 [67]
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Drug(s) Targeting Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PINOCEMBRIN DM96VWD N. A. N. A. Phase 2 [7]
NARINGENIN DMHAZLM N. A. N. A. Phase 1 [7]
Chrysin DM7V2LG Discovery agent N.A. Investigative [7]
KAEMPFEROL DMHEMUB Discovery agent N.A. Investigative [7]
ISORHAMNETIN DMQ4Z6E Discovery agent N.A. Investigative [7]
ACACETIN DMQOB0X Discovery agent N.A. Investigative [7]
TRISMETHOXYRESVERATROL DM6USPC Discovery agent N.A. Investigative [68]
Galangin DM5TQ2O Discovery agent N.A. Investigative [7]
CHRYSOERIOL DM96ECL Discovery agent N.A. Investigative [7]
DIOSMETIN DM4KXIM Discovery agent N.A. Investigative [7]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [394]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [473]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [474]
Estrone DM5T6US Acne vulgaris ED80 Approved [475]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [476]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [477]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [478]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [479]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [419]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [69]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [70]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [71]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [72]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [73]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [74]
Ethacrynic acid DM60QMR Edema MG29 Approved [75]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [76]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [77]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [78]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [80]
Selenium DM25CGV N. A. N. A. Approved [81]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [82]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [83]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [84]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [86]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [88]
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Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [89]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [89]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [89]
Capsaicin DMGMF6V Back pain ME84.Z Approved [90]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [91]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [92]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [93]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [94]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [95]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [96]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [97]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [98]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [99]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [100]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [101]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [102]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [103]
Capsaicin DMGMF6V Back pain ME84.Z Approved [104]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [105]
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Drug(s) Affected By Catalase (CAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [106]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [107]
Haloperidol DM96SE0 Delirium Approved [96]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Selenium DM25CGV N. A. N. A. Approved [109]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [110]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [111]
Methotrexate DM2TEOL Anterior urethra cancer Approved [112]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [113]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
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Drug(s) Affected By Cytochrome P450 11B1, mitochondrial (CYP11B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [114]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [115]
Quercetin DM3NC4M Obesity 5B81 Approved [116]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Ethanol DMDRQZU Chronic pain MG30 Approved [118]
Potassium Chloride DMMTAJC Hypokalemia 5C77 Approved [119]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [120]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
Dalcetrapib DMKNCVM Acute coronary syndrome BA41 Phase 3 [121]
Anacetrapib DMP2BFG Arteriosclerosis BD40 Phase 3 [121]
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Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fomepizole DM6VOWQ Athylene glycol or methanol poisoning NE61 Approved [122]
Ademetionine DMYQDBO Hepatic fibrosis DB93.0 Approved [123]
Theophylline DMRJFN9 Bronchitis CA20 Approved [96]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [124]
Ethanol DMDRQZU Chronic pain MG30 Approved [125]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [126]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Didanosine DMI2QPE Human immunodeficiency virus infection 1C62 Approved [96]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [128]
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Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [98]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [129]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [101]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [100]
Capsaicin DMGMF6V Back pain ME84.Z Approved [90]
Zafirlukast DMHNQOG Asthma CA23 Approved [130]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [101]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [131]
Fluconazole DMOWZ6B Cryptococcal meningitis Approved [100]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [101]
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Drug(s) Affected By Suppressor of cytokine signaling 3 (SOCS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [132]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Methotrexate DM2TEOL Anterior urethra cancer Approved [134]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [135]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [136]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Fedratinib DM4ZBK6 Myelofibrosis 2A20.2 Approved [138]
Panobinostat DM58WKG Chronic graft versus host disease Approved [139]
Pyrimethamine DM5X7VY Malaria 1F40-1F45 Approved [138]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [136]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [140]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [141]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [142]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [143]
Selenium DM25CGV N. A. N. A. Approved [144]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [140]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [145]
Methotrexate DM2TEOL Anterior urethra cancer Approved [134]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [145]
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Drug(s) Affected By Tumor protein p73 (TP73)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [146]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [147]
Etretinate DM2CZFA Keratosis ED56 Approved [148]
Quercetin DM3NC4M Obesity 5B81 Approved [149]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [150]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [151]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [152]
Menthol DMG2KW7 Back pain ME84.Z Approved [153]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [154]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [148]
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Drug(s) Affected By Prominin-1 (PROM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [155]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [156]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [157]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [158]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [151]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [159]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [160]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [161]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [162]
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Drug(s) Affected By Prostate stem cell antigen (PSCA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Quercetin DM3NC4M Obesity 5B81 Approved [163]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [164]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [165]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [166]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [126]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [167]
ACYLINE DM9GRTK Prostate cancer 2C82.0 Phase 2 [168]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [169]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [170]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [170]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [171]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [172]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [173]
Etidronic acid DM1XHYJ Bone Paget disease Approved [170]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [170]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [170]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [174]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [175]
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Drug(s) Affected By CCN family member 5 (CCN5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [132]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [176]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [177]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [177]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [177]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [126]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [178]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [179]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [180]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [181]
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Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [182]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [183]
Quercetin DM3NC4M Obesity 5B81 Approved [184]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [186]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [187]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [188]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [189]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [186]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [190]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Erythropoietin (EPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [191]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [192]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [193]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [165]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [194]
Fenoterol DMIP3ZV Asthma CA23 Approved [195]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [196]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [197]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [198]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glycophorin-A (GYPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [199]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [200]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [201]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [202]
Teriflunomide DMQ2FKJ Hyperlipidaemia 5C80 Approved [203]
Arsenic DMTL2Y1 N. A. N. A. Approved [204]
Allopurinol DMLPAOB Gout FA25 Approved [96]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [205]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [206]
Butanoic Acid DMTAJP7 Discovery agent N.A. Investigative [207]
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Drug(s) Affected By Fibronectin (FN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [208]
Methotrexate DM2TEOL Anterior urethra cancer Approved [112]
Quercetin DM3NC4M Obesity 5B81 Approved [209]
Aripiprazole DM3NUMH Bipolar I disorder Approved [210]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [211]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [212]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [213]
Ethacrynic acid DM60QMR Edema MG29 Approved [214]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [215]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [216]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Estrogen receptor (ESR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [217]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [218]
Gefitinib DM15F0X Colon adenocarcinoma Approved [219]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [220]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [221]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [222]
Quercetin DM3NC4M Obesity 5B81 Approved [223]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [224]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [220]
Estrone DM5T6US Acne vulgaris ED80 Approved [225]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interstitial collagenase (MMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [226]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Etretinate DM2CZFA Keratosis ED56 Approved [228]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [229]
Methotrexate DM2TEOL Anterior urethra cancer Approved [230]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [231]
Quercetin DM3NC4M Obesity 5B81 Approved [232]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [233]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [234]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sex hormone-binding globulin (SHBG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [236]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Fructose DM43AN2 Vomiting MD90 Approved [237]
Oxcarbazepine DM5PU6O Epilepsy 8A60-8A68 Approved [238]
Estrone DM5T6US Acne vulgaris ED80 Approved [239]
Testosterone DM7HUNW Hot flushes GA30 Approved [240]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Dienestrol DMBSXI0 Atrophic vaginitis GA30.2 Approved [239]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [239]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [239]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [242]
Methotrexate DM2TEOL Anterior urethra cancer Approved [112]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [243]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [244]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [245]
Paclitaxel DMLB81S Breast carcinoma Approved [246]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [247]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [248]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [249]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [250]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-4 (IL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [251]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [252]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [253]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [254]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [255]
Prednisone DM2HG4X Acute asthma CA23 Approved [256]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [257]
Methotrexate DM2TEOL Anterior urethra cancer Approved [112]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [135]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [258]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Progesterone receptor (PGR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [259]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [260]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [261]
Estrone DM5T6US Acne vulgaris ED80 Approved [262]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [263]
Testosterone DM7HUNW Hot flushes GA30 Approved [264]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [265]
Goserelin DMAT8CG Breast cancer 2C60-2C65 Approved [266]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [267]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [226]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [268]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [269]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Selenium DM25CGV N. A. N. A. Approved [270]
Etretinate DM2CZFA Keratosis ED56 Approved [148]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [82]
Methotrexate DM2TEOL Anterior urethra cancer Approved [230]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [271]
Quercetin DM3NC4M Obesity 5B81 Approved [272]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hepatocyte growth factor receptor (MET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [273]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [274]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [275]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [275]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [275]
Methotrexate DM2TEOL Anterior urethra cancer Approved [177]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [275]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [276]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [177]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fructose-1,6-bisphosphatase 1 (FBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [163]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [277]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [278]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [213]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [279]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [280]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [281]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [282]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [283]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [284]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [285]
Gefitinib DM15F0X Colon adenocarcinoma Approved [286]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [287]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [288]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [289]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [290]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [289]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [291]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [292]
Methotrexate DM2TEOL Anterior urethra cancer Approved [293]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myb-related protein A (MYBL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [294]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [295]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Panobinostat DM58WKG Chronic graft versus host disease Approved [296]
Estrone DM5T6US Acne vulgaris ED80 Approved [294]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [297]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [298]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [165]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [299]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [295]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [300]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [301]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [302]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [303]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [96]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [285]
Verapamil DMA7PEW Angina pectoris BA40 Approved [304]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [305]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [306]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [80]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [307]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [308]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [309]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [310]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [311]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [312]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [311]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [278]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [313]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [314]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [315]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [316]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [317]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [318]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [317]
Methotrexate DM2TEOL Anterior urethra cancer Approved [134]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [317]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Fluoxetine DM3PD2C Bipolar depression Approved [317]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [319]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cystic fibrosis transmembrane conductance regulator (CFTR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivacaftor DMZC1HS Cystic fibrosis CA25 Approved [325]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [326]
Quercetin DM3NC4M Obesity 5B81 Approved [327]
Miglustat DM5J64S Niemann-Pick disease type C Approved [328]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [329]
Milrinone DM8TUPF Congestive heart failure BD10 Approved [326]
Oxidized glutathione DM9EQC0 Breast cancer 2C60-2C65 Approved [330]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [330]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [151]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [226]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [268]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [331]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Selenium DM25CGV N. A. N. A. Approved [270]
Etretinate DM2CZFA Keratosis ED56 Approved [148]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [290]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [332]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [333]
Methotrexate DM2TEOL Anterior urethra cancer Approved [334]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [335]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [336]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [337]
Gefitinib DM15F0X Colon adenocarcinoma Approved [338]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [339]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [340]
Methotrexate DM2TEOL Anterior urethra cancer Approved [341]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [342]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [83]
Quercetin DM3NC4M Obesity 5B81 Approved [343]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [344]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [345]
Gefitinib DM15F0X Colon adenocarcinoma Approved [182]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [346]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [347]
Quercetin DM3NC4M Obesity 5B81 Approved [348]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [349]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [350]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [351]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [96]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [352]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [353]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [354]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [355]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [356]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [357]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [84]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [358]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [359]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [360]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [306]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [361]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [362]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [363]
Gefitinib DM15F0X Colon adenocarcinoma Approved [364]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [365]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [366]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [367]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [359]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [368]
Paclitaxel DMLB81S Breast carcinoma Approved [369]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [370]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [358]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [96]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [306]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [361]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [226]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [339]
Methotrexate DM2TEOL Anterior urethra cancer Approved [230]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [176]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [371]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [372]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [373]
Testosterone DM7HUNW Hot flushes GA30 Approved [374]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [375]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [376]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [248]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [80]
Gefitinib DM15F0X Colon adenocarcinoma Approved [377]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [346]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [378]
Selenium DM25CGV N. A. N. A. Approved [81]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [379]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [380]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [381]
Folic Acid DMEMBJC Colorectal carcinoma Approved [382]
Methotrexate DM2TEOL Anterior urethra cancer Approved [383]
Quercetin DM3NC4M Obesity 5B81 Approved [384]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [385]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [386]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [387]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [388]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [389]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [389]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [390]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [391]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [331]
Gefitinib DM15F0X Colon adenocarcinoma Approved [392]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [393]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [394]
Etretinate DM2CZFA Keratosis ED56 Approved [148]
Prednisone DM2HG4X Acute asthma CA23 Approved [395]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [290]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [140]
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Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [96]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [396]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [397]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [398]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [399]
Methotrexate DM2TEOL Anterior urethra cancer Approved [134]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [400]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [401]
Quercetin DM3NC4M Obesity 5B81 Approved [402]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [403]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [404]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [405]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [245]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [406]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [407]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [408]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [409]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [410]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [352]
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Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor C (CDKN2C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [285]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [176]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [411]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [412]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [413]
Testosterone DM7HUNW Hot flushes GA30 Approved [374]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [374]
Leflunomide DMR8ONJ Arthritis FA20 Approved [414]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [165]
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Drug(s) Affected By Stromal cell-derived factor 1 (CXCL12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [415]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [294]
Methotrexate DM2TEOL Anterior urethra cancer Approved [112]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [416]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [213]
Panobinostat DM58WKG Chronic graft versus host disease Approved [139]
Estrone DM5T6US Acne vulgaris ED80 Approved [294]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [417]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [151]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [418]
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Drug(s) Affected By Transcription factor SOX-2 (SOX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [419]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [155]
Quercetin DM3NC4M Obesity 5B81 Approved [420]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [421]
Panobinostat DM58WKG Chronic graft versus host disease Approved [139]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [422]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [423]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [424]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [425]
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Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [316]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [354]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [426]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [427]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [428]
Quercetin DM3NC4M Obesity 5B81 Approved [429]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [176]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [430]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [431]
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Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [432]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [337]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [433]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [434]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [435]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [435]
Methotrexate DM2TEOL Anterior urethra cancer Approved [230]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [342]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [436]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [437]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [438]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [439]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [285]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [305]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [440]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [441]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [288]
Meloxicam DM2AR7L Arthritis FA20 Approved [442]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [443]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [444]
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Drug(s) Affected By Laminin subunit beta-2 (LAMB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Quercetin DM3NC4M Obesity 5B81 Approved [445]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [278]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [446]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [447]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [448]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [166]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [133]
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Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [449]
Gefitinib DM15F0X Colon adenocarcinoma Approved [286]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [440]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [450]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [434]
Methotrexate DM2TEOL Anterior urethra cancer Approved [112]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [451]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [452]
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Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [155]
Quercetin DM3NC4M Obesity 5B81 Approved [453]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [319]
Panobinostat DM58WKG Chronic graft versus host disease Approved [139]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [422]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [454]
Testosterone DM7HUNW Hot flushes GA30 Approved [455]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [456]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [457]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [458]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [352]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [147]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [288]
Methotrexate DM2TEOL Anterior urethra cancer Approved [230]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [277]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [278]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [459]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [150]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [460]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [461]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [462]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [463]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Gefitinib DM15F0X Colon adenocarcinoma Approved [464]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [465]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [288]
Selenium DM25CGV N. A. N. A. Approved [81]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [443]
Methotrexate DM2TEOL Anterior urethra cancer Approved [112]
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Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [466]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [467]
Prednisone DM2HG4X Acute asthma CA23 Approved [468]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [468]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [469]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [470]
Epinephrine DM3KJBC Acute asthma CA23 Approved [471]
Quercetin DM3NC4M Obesity 5B81 Approved [307]
Fluoxetine DM3PD2C Bipolar depression Approved [472]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [349]
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Drug(s) Affected By Protein GREB1 (GREB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [132]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [295]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [480]
Testosterone DM7HUNW Hot flushes GA30 Approved [481]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [374]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [482]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [295]
Nandrolone DMFWKG1 Osteoporosis FB83.0 Approved [483]
Mestranol DMG3F94 Contraception QA21 Approved [295]
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Drug(s) Affected By Quinone oxidoreductase PIG3 (TP53I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [288]
Methotrexate DM2TEOL Anterior urethra cancer Approved [230]
Quercetin DM3NC4M Obesity 5B81 Approved [163]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [484]
Amifostine DM5FL14 Mucositis CA00 Approved [485]
Testosterone DM7HUNW Hot flushes GA30 Approved [481]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [486]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [487]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [487]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [487]
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Drug(s) Affected By Dehydrogenase/reductase SDR family member 11 (DHRS11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [488]
Quercetin DM3NC4M Obesity 5B81 Approved [488]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [213]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [165]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [488]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [489]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [160]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [447]
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Drug(s) Affected By Estrogen receptor beta (ESR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [132]
Gefitinib DM15F0X Colon adenocarcinoma Approved [490]
Quercetin DM3NC4M Obesity 5B81 Approved [491]
Estrone DM5T6US Acne vulgaris ED80 Approved [492]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [493]
Testosterone DM7HUNW Hot flushes GA30 Approved [494]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [495]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [496]
Mestranol DMG3F94 Contraception QA21 Approved [497]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [498]
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Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [345]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [499]
Methotrexate DM2TEOL Anterior urethra cancer Approved [230]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [500]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [186]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [501]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [187]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [502]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [503]
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Drug(s) Affected By Tumor protein 63 (TP63)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [147]
Quercetin DM3NC4M Obesity 5B81 Approved [163]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [504]
Panobinostat DM58WKG Chronic graft versus host disease Approved [505]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [280]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [159]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [506]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [282]
Topotecan DMP6G8T Central nervous system neoplasm Approved [507]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [166]
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Drug(s) Affected By Homeobox protein NANOG (NANOG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [508]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [155]
Quercetin DM3NC4M Obesity 5B81 Approved [453]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [319]
Panobinostat DM58WKG Chronic graft versus host disease Approved [139]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [422]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [454]
Testosterone DM7HUNW Hot flushes GA30 Approved [455]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [482]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [425]
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Drug(s) Affected By Beta-1,3-galactosyltransferase 5 (B3GALT5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [509]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [160]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [282]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [166]
Arsenic DMTL2Y1 N. A. N. A. Approved [510]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [511]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [512]
KAEMPFEROL DMHEMUB Discovery agent N.A. Investigative [13]
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Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [126]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [513]
Minoxidil DMA2Z4F Alopecia ED70 Approved [514]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [515]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [514]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [516]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [312]
Methotrexate DM2TEOL Anterior urethra cancer Approved [517]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
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Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [142]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [415]
Selenium DM25CGV N. A. N. A. Approved [81]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [518]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [519]
Methotrexate DM2TEOL Anterior urethra cancer Approved [520]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [411]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [521]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aldose reductase (AKR1B1) TTFBNVI ALDR_HUMAN Inhibitor [2]
Androgen receptor messenger RNA (AR mRNA) TTKPW01 ANDR_HUMAN Inhibitor [3]
Aromatase (CYP19A1) TTSZLWK CP19A_HUMAN Inhibitor [4]
Casein kinase II alpha (CSNK2A1) TTER6YH CSK21_HUMAN Inhibitor [5]
Cyclin-dependent kinase 6 (CDK6) TTO0FDJ CDK6_HUMAN Inhibitor [6]
Cytochrome P450 1B1 (CYP1B1) TTI84H7 CP1B1_HUMAN Inhibitor [7]
Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) TTIWB6L DHB1_HUMAN Inhibitor [8]
Influenza Neuraminidase (Influ NA) TT50QJ3 NRAM_I33A0 Inhibitor [9]
Plasmodium CDK Pfmrk (Malaria Pfmrk) TTSFWA7 P90584_PLAFA Inhibitor [10]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [11]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Gene/Protein Processing [12]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Protein Interaction/Cellular Processes [11]
Beta-1,3-galactosyltransferase 5 (B3GALT5) OTWXPEMU B3GT5_HUMAN Gene/Protein Processing [13]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [14]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Gene/Protein Processing [15]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Protein Interaction/Cellular Processes [11]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Protein Interaction/Cellular Processes [11]
Catalase (CAT) OTHEBX9R CATA_HUMAN Gene/Protein Processing [16]
CCN family member 5 (CCN5) OTADU8JJ CCN5_HUMAN Gene/Protein Processing [17]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4136).
2 Erigeroflavanone, a flavanone derivative from the flowers of Erigeron annuus with protein glycation and aldose reductase inhibitory activity. J Nat Prod. 2008 Apr;71(4):713-5.
3 Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4706-10.
4 Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64.
5 Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2920-3.
6 Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. J Med Chem. 2005 Feb 10;48(3):737-43.
7 Selective inhibition of methoxyflavonoids on human CYP1B1 activity. Bioorg Med Chem. 2010 Sep 1;18(17):6310-5.
8 Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries. J Med Chem. 2008 Jul 24;51(14):4188-99.
9 Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities. Bioorg Med Chem. 2009 Oct 1;17(19):6816-23.
10 A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different class... J Med Chem. 2004 Oct 21;47(22):5418-26.
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140 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
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