Details of the Drug Combination

General Information of Drug Combination (ID: DCTTN11)

Drug Combination Name
Irinotecan DTI-015
Indication
Disease Entry Status REF
Brain and Central Nervous System Tumors Phase 1 [1]
Component Drugs Irinotecan   DMP6SC2 DTI-015   DMXZRW0
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Irinotecan
Disease Entry ICD 11 Status REF
Adenocarcinoma 2D40 Approved [2]
Advanced cancer 2A00-2F9Z Approved [2]
Appendiceal neoplasm N.A. Approved [2]
Astrocytoma 2A00.0Y Approved [2]
Brain glioma N.A. Approved [2]
Colon adenocarcinoma N.A. Approved [2]
Colorectal cancer 2B91.Z Approved [3]
Endocrine gland neoplasm N.A. Approved [2]
Kidney neoplasm N.A. Approved [2]
Metastasis from malignant tumor of colon N.A. Approved [2]
Peritoneal neoplasm N.A. Approved [2]
Rectal adenocarcinoma 2B92 Approved [2]
Rectal neoplasm N.A. Approved [2]
Rectum mucinous adenocarcinoma N.A. Approved [2]
Adult glioblastoma N.A. Investigative [2]
Colon cancer 2B90.Z Investigative [2]
Colon mucinous adenocarcinoma N.A. Investigative [2]
Diarrhea ME05.1 Investigative [2]
Gastric cancer 2B72 Investigative [2]
Neuroblastoma 2D11.2 Investigative [2]
Irinotecan Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
DNA topoisomerase I (TOP1) TTGTQHC TOP1_HUMAN Modulator [17]
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Irinotecan Interacts with 6 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [18]
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [19]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [19]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [20]
Multidrug resistance-associated protein 4 (ABCC4) DTCSGPB MRP4_HUMAN Substrate [21]
Multidrug resistance-associated protein 5 (ABCC5) DTYVM24 MRP5_HUMAN Substrate [22]
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⏷ Show the Full List of 6 DTP(s)
Irinotecan Interacts with 8 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [23]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [24]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Metabolism [25]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Metabolism [26]
Carboxylesterase 1 (CES1) DEB30C5 EST1_HUMAN Metabolism [23]
Carboxylesterase 3 (CES3) DEMI4VE EST3_HUMAN Metabolism [27]
Carboxylesterase 2 (CES2) DETHCPD EST2_HUMAN Metabolism [27]
Beta-glucuronidase (uidA) DE9RA0I BGLR_ECOLI Metabolism [28]
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⏷ Show the Full List of 8 DME(s)
Irinotecan Interacts with 469 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Increases Expression [29]
Carboxylesterase 3 (CES3) OT00OP43 EST3_HUMAN Increases Hydrolysis [27]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases Response To Substance [30]
Liver carboxylesterase 1 (CES1) OT9L0LR8 EST1_HUMAN Increases Response To Substance [30]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Decreases Expression [12]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Decreases Response To Substance [31]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Increases Response To Substance [30]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Response To Substance [31]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Increases ADR [32]
Thiopurine S-methyltransferase (TPMT) OTFOX70W TPMT_HUMAN Increases Expression [12]
Cytochrome P450 2A6 (CYP2A6) OT52TWG3 CP2A6_HUMAN Decreases Activity [33]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Decreases Activity [33]
Annexin A2 (ANXA2) OTFNS0CC ANXA2_HUMAN Increases Expression [34]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Increases Expression [34]
FXYD domain-containing ion transport regulator 3 (FXYD3) OT9PPRHE FXYD3_HUMAN Increases Expression [34]
B-cell CLL/lymphoma 9 protein (BCL9) OTRBIPR4 BCL9_HUMAN Increases Expression [11]
Chromodomain-helicase-DNA-binding protein 1 (CHD1) OT9R9G0H CHD1_HUMAN Decreases Expression [11]
Prostaglandin E synthase (PTGES) OTB7YQFU PTGES_HUMAN Increases Expression [11]
tRNA (TRDMT1) OTAYQ8ZF TRDMT_HUMAN Decreases Expression [11]
Guanine nucleotide exchange factor DBS (MCF2L) OTEURA8N MCF2L_HUMAN Decreases Expression [11]
Fanconi anemia group G protein (FANCG) OT7MC8TZ FANCG_HUMAN Increases Expression [11]
Monocarboxylate transporter 5 (SLC16A4) OT1YXBKC MOT5_HUMAN Decreases Expression [11]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [11]
Prominin-1 (PROM1) OTBHV8NX PROM1_HUMAN Decreases Expression [11]
A-kinase anchor protein 10, mitochondrial (AKAP10) OTPNFTOU AKA10_HUMAN Decreases Expression [11]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) OT80DZMT BUB1_HUMAN Decreases Expression [11]
Hyaluronan mediated motility receptor (HMMR) OT4M0JTZ HMMR_HUMAN Decreases Expression [11]
G2/mitotic-specific cyclin-B2 (CCNB2) OTIEXTDK CCNB2_HUMAN Decreases Expression [11]
Heat shock 70 kDa protein 4L (HSPA4L) OT181WZB HS74L_HUMAN Decreases Expression [11]
Aldehyde dehydrogenase 1A1 (ALDH1A1) OTCUWZKB AL1A1_HUMAN Decreases Expression [11]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [11]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [11]
Lactotransferrin (LTF) OT8JWCZ0 TRFL_HUMAN Decreases Expression [11]
Histidine-rich glycoprotein (HRG) OTPLUFOG HRG_HUMAN Increases Expression [11]
Thy-1 membrane glycoprotein (THY1) OTVONVTB THY1_HUMAN Increases Expression [11]
Insulin-like growth factor I (IGF1) OTIIZR61 IGF1_HUMAN Increases Expression [11]
Myeloperoxidase (MPO) OTOOXLIN PERM_HUMAN Decreases Expression [11]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [11]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [11]
Integrin alpha-V (ITGAV) OTAM7JTR ITAV_HUMAN Decreases Expression [11]
Annexin A6 (ANXA6) OT9KIQ0Y ANXA6_HUMAN Increases Expression [11]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Increases Expression [11]
Sulfotransferase 1A3 (SULT1A4) OTHJ8WWV ST1A3_HUMAN Increases Expression [11]
Serine/threonine-protein kinase A-Raf (ARAF) OTZJ0FNO ARAF_HUMAN Increases Expression [11]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Decreases Expression [11]
Collagen alpha-1(VI) chain (COL6A1) OTYKSCOB CO6A1_HUMAN Increases Expression [11]
Keratin, type II cytoskeletal 5 (KRT5) OTVGI9HT K2C5_HUMAN Decreases Expression [11]
Nidogen-1 (NID1) OTKLBLS6 NID1_HUMAN Increases Expression [11]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Increases Expression [11]
Protein C-ets-2 (ETS2) OTPVHOZ7 ETS2_HUMAN Increases Expression [11]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [11]
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PPP3CB) OTEGNEHW PP2BB_HUMAN Decreases Expression [11]
SH2/SH3 adapter protein NCK1 (NCK1) OTKYZ4OP NCK1_HUMAN Decreases Expression [11]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Increases Expression [11]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [11]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [11]
Interferon-induced GTP-binding protein Mx2 (MX2) OT05NF37 MX2_HUMAN Decreases Expression [11]
Integrin alpha-X (ITGAX) OTOGIMHE ITAX_HUMAN Increases Expression [11]
Myelin and lymphocyte protein (MAL) OTBM30SW MAL_HUMAN Increases Expression [11]
Glutathione peroxidase 3 (GPX3) OT6PK94R GPX3_HUMAN Increases Expression [11]
5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS2) OTJXOUCL HEM0_HUMAN Increases Expression [11]
Receptor-type tyrosine-protein phosphatase delta (PTPRD) OTZPJ3GX PTPRD_HUMAN Increases Expression [11]
Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) OTGP7D5Y GATA3_HUMAN Decreases Expression [11]
Adenomatous polyposis coli protein (APC) OTKV0TIK APC_HUMAN Decreases Expression [11]
Retinoblastoma-like protein 1 (RBL1) OTDEBFYC RBL1_HUMAN Decreases Expression [11]
AT-rich interactive domain-containing protein 4A (ARID4A) OT1XKBZ0 ARI4A_HUMAN Decreases Expression [11]
M-phase inducer phosphatase 2 (CDC25B) OT12MSRY MPIP2_HUMAN Decreases Expression [11]
Syndecan-4 (SDC4) OTKUVUGZ SDC4_HUMAN Increases Expression [11]
C-C chemokine receptor type 1 (CCR1) OT4FC783 CCR1_HUMAN Increases Expression [11]
G-protein coupled receptor 183 (GPR183) OTRILX7G GP183_HUMAN Increases Expression [11]
CD70 antigen (CD70) OTHB2AL1 CD70_HUMAN Increases Expression [11]
T-lymphocyte activation antigen CD80 (CD80) OTJBLUQE CD80_HUMAN Increases Expression [11]
Dual specificity protein kinase TTK (TTK) OTBY1Z5H TTK_HUMAN Decreases Expression [11]
DNA replication licensing factor MCM4 (MCM4) OT19PNNG MCM4_HUMAN Decreases Expression [11]
Replication factor C subunit 3 (RFC3) OT1MS7AO RFC3_HUMAN Decreases Expression [11]
Cyclin-F (CCNF) OTJFVU43 CCNF_HUMAN Decreases Expression [11]
Transcription factor ETV6 (ETV6) OTCZMG61 ETV6_HUMAN Decreases Expression [11]
DNA mismatch repair protein Msh2 (MSH2) OT10H1AB MSH2_HUMAN Decreases Expression [11]
Hydroxycarboxylic acid receptor 3 (HCAR3) OTJBHLX0 HCAR3_HUMAN Increases Expression [11]
Centromere protein F (CENPF) OT7AG0SW CENPF_HUMAN Decreases Expression [11]
Caspase-4 (CASP4) OTVQTV1L CASP4_HUMAN Decreases Expression [11]
5-formyltetrahydrofolate cyclo-ligase (MTHFS) OTZ39JNR MTHFS_HUMAN Decreases Expression [11]
Protein Tob1 (TOB1) OTNW949D TOB1_HUMAN Increases Expression [11]
C-C chemokine receptor type 6 (CCR6) OT61JMYX CCR6_HUMAN Decreases Expression [11]
Serine/threonine-protein kinase Nek2 (NEK2) OT1H27HO NEK2_HUMAN Decreases Expression [11]
Serine/threonine-protein kinase PLK1 (PLK1) OTRZX45T PLK1_HUMAN Decreases Expression [11]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Increases Expression [11]
UV excision repair protein RAD23 homolog B (RAD23B) OT0PGOG3 RD23B_HUMAN Decreases Expression [11]
Sestrin-2 (SESN2) OT889IXY SESN2_HUMAN Increases Expression [11]
Neutrophil defensin 1 (DEFA1) OT5N1B9B DEF1_HUMAN Decreases Expression [11]
Ras-related C3 botulinum toxin substrate 3 (RAC3) OT2RE7A7 RAC3_HUMAN Increases Expression [11]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6) OT1SLUZH TSG6_HUMAN Decreases Expression [11]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Expression [11]
Runt-related transcription factor 1 (RUNX1) OTU7J84H RUNX1_HUMAN Decreases Expression [11]
Transcription factor Spi-B (SPIB) OTO4YKYI SPIB_HUMAN Increases Expression [11]
Myocyte-specific enhancer factor 2B (MEF2B) OT880SE6 MEF2B_HUMAN Increases Expression [11]
DNA-binding protein inhibitor ID-2 (ID2) OT0U1D53 ID2_HUMAN Decreases Expression [11]
Dual specificity protein phosphatase 2 (DUSP2) OTH54FMR DUS2_HUMAN Increases Expression [11]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B) OTOA8WU2 PDE4B_HUMAN Decreases Expression [11]
Regulator of G-protein signaling 1 (RGS1) OTGXJYMG RGS1_HUMAN Increases Expression [11]
Dystrophia myotonica WD repeat-containing protein (DMWD) OT0CBZ6F DMWD_HUMAN Increases Expression [11]
Histone acetyltransferase p300 (EP300) OTL8QJDX EP300_HUMAN Decreases Expression [11]
Dihydropyrimidine dehydrogenase (DPYD) OTWRF2NR DPYD_HUMAN Decreases Expression [11]
Tyrosine-protein phosphatase non-receptor type 13 (PTPN13) OTESFZSO PTN13_HUMAN Decreases Expression [11]
Rho GTPase-activating protein 5 (ARHGAP5) OTOQELUN RHG05_HUMAN Decreases Expression [11]
MAL-like protein (MALL) OTKGZ89D MALL_HUMAN Increases Expression [11]
TNF receptor-associated factor 1 (TRAF1) OTTLM5RU TRAF1_HUMAN Decreases Expression [11]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) OTXNGZCG MD2L1_HUMAN Decreases Expression [11]
Cyclin-dependent kinase 5 activator 2 (CDK5R2) OTNUTLPU CD5R2_HUMAN Increases Expression [11]
Centromere protein R (ITGB3BP) OT6Q7GR3 CENPR_HUMAN Decreases Expression [11]
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) OTPLXCDN DYR1A_HUMAN Decreases Expression [11]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Increases Expression [11]
Krueppel-like factor 9 (KLF9) OTBFEJRQ KLF9_HUMAN Increases Expression [11]
Cyclin-dependent kinase 13 (CDK13) OT3P7JF1 CDK13_HUMAN Decreases Expression [11]
Protein Tob2 (TOB2) OTEEHL60 TOB2_HUMAN Increases Expression [11]
Serine/threonine-protein kinase 38 (STK38) OTKMYCYR STK38_HUMAN Increases Expression [11]
Retinoblastoma-binding protein 5 (RBBP5) OT12W2MK RBBP5_HUMAN Decreases Expression [11]
Receptor tyrosine-protein kinase erbB-4 (ERBB4) OT9L6C41 ERBB4_HUMAN Increases Expression [11]
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF2) OTRHB9SR NHRF2_HUMAN Increases Expression [11]
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) OTBOSJHO TRADD_HUMAN Increases Expression [11]
Nuclear receptor coactivator 1 (NCOA1) OTLIUJQD NCOA1_HUMAN Increases Expression [11]
Tubulin-specific chaperone C (TBCC) OTBF0X8R TBCC_HUMAN Increases Expression [11]
Cyclin-dependent kinase inhibitor 3 (CDKN3) OTBE3H07 CDKN3_HUMAN Decreases Expression [11]
Receptor-type tyrosine-protein phosphatase-like N (PTPRN) OTAP7NOL PTPRN_HUMAN Increases Expression [11]
B-cell CLL/lymphoma 7 protein family member A (BCL7A) OTYFUJTP BCL7A_HUMAN Increases Expression [11]
Transmembrane protein 41B (TMEM41B) OTW0B0KS TM41B_HUMAN Decreases Expression [11]
Transcription initiation factor TFIID subunit 2 (TAF2) OTTIGJ9M TAF2_HUMAN Decreases Expression [11]
DNA cross-link repair 1A protein (DCLRE1A) OT68PVSD DCR1A_HUMAN Decreases Expression [11]
C-myc promoter-binding protein (DENND4A) OT8FFZ29 MYCPP_HUMAN Decreases Expression [11]
COMM domain-containing protein 6 (COMMD6) OTRZQJFW COMD6_HUMAN Increases Expression [11]
Bone morphogenetic protein 8A (BMP8A) OT1997IN BMP8A_HUMAN Increases Expression [11]
Pleckstrin homology domain-containing family H member 3 (PLEKHH3) OTREOQBO PKHH3_HUMAN Increases Expression [11]
DNA damage-binding protein 2 (DDB2) OTO8HVVB DDB2_HUMAN Increases Expression [11]
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) OTMDVWPS DYRK2_HUMAN Decreases Expression [11]
Histone H2A type 1-C (H2AC6) OTF3YK7V H2A1C_HUMAN Decreases Expression [11]
Aurora kinase B (AURKB) OTIY4VHU AURKB_HUMAN Decreases Expression [11]
Sorting nexin-18 (SNX18) OT68KT3X SNX18_HUMAN Decreases Expression [11]
Oncostatin-M-specific receptor subunit beta (OSMR) OTORWHPL OSMR_HUMAN Increases Expression [11]
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) OTQR6ENW M3K5_HUMAN Decreases Expression [11]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [11]
Ubiquitin-like-conjugating enzyme ATG10 (ATG10) OTVRPC5X ATG10_HUMAN Decreases Expression [11]
Serine/threonine-protein kinase PLK3 (PLK3) OT19CT2Z PLK3_HUMAN Increases Expression [11]
E3 ubiquitin-protein ligase Topors (TOPORS) OT1ERFFQ TOPRS_HUMAN Decreases Expression [11]
Serine/threonine-protein kinase PLK2 (PLK2) OTKMJXJ8 PLK2_HUMAN Increases Expression [11]
Gamma-adducin (ADD3) OTDRSHAZ ADDG_HUMAN Decreases Expression [11]
Targeting protein for Xklp2 (TPX2) OTWLJYH0 TPX2_HUMAN Decreases Expression [11]
Protocadherin gamma-C3 (PCDHGC3) OTDXTUMI PCDGK_HUMAN Increases Expression [11]
Tyrosine-protein phosphatase non-receptor type 22 (PTPN22) OTDCNTC3 PTN22_HUMAN Increases Expression [11]
Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1) OTBV52DR SMHD1_HUMAN Decreases Expression [12]
Serine/threonine-protein kinase Sgk1 (SGK1) OT301T1U SGK1_HUMAN Increases Expression [12]
Matrilin-2 (MATN2) OTVDR68G MATN2_HUMAN Increases Expression [12]
Krev interaction trapped protein 1 (KRIT1) OT58AP1I KRIT1_HUMAN Decreases Expression [12]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Decreases Expression [12]
Calmegin (CLGN) OTEWVFQV CLGN_HUMAN Increases Expression [12]
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) OTB3BFCV HNRDL_HUMAN Decreases Expression [12]
Centrosomal protein of 290 kDa (CEP290) OTVN52VH CE290_HUMAN Decreases Expression [12]
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (ANKRD28) OTRBREQ9 ANR28_HUMAN Decreases Expression [12]
FYN-binding protein 1 (FYB1) OT6345CH FYB1_HUMAN Decreases Expression [12]
Protein phosphatase 1D (PPM1D) OT8NLZ9D PPM1D_HUMAN Increases Expression [12]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Decreases Expression [12]
Krueppel-like factor 4 (KLF4) OT4O9RQW KLF4_HUMAN Increases Expression [12]
Density-regulated protein (DENR) OTXP9HOY DENR_HUMAN Decreases Expression [12]
E3 ubiquitin-protein ligase MARCHF6 (MARCHF6) OTBTA03N MARH6_HUMAN Increases Expression [12]
Oligophrenin-1 (OPHN1) OTDURZAV OPHN1_HUMAN Increases Expression [12]
NEDD4-binding protein 1 (N4BP1) OTN2TL6N N4BP1_HUMAN Decreases Expression [12]
Ankyrin repeat domain-containing protein 17 (ANKRD17) OTQ3DYEP ANR17_HUMAN Decreases Expression [12]
Nuclear receptor corepressor 1 (NCOR1) OT04XNOU NCOR1_HUMAN Decreases Expression [12]
Death effector domain-containing protein (DEDD) OTIL349E DEDD_HUMAN Decreases Expression [12]
Glutaredoxin-3 (GLRX3) OTUPAU1N GLRX3_HUMAN Affects Expression [12]
Tubulin polymerization-promoting protein (TPPP) OTCFMSUF TPPP_HUMAN Increases Expression [12]
Protein transport protein Sec31A (SEC31A) OT2U42AC SC31A_HUMAN Decreases Expression [12]
SR-related and CTD-associated factor 4 (SCAF4) OTFGHB1E SCAF4_HUMAN Decreases Expression [12]
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) OT9QIHEQ RECK_HUMAN Increases Expression [12]
Tissue-type plasminogen activator (PLAT) OTQPDNAB TPA_HUMAN Decreases Expression [12]
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Decreases Expression [12]
HLA class I histocompatibility antigen, B alpha chain (HLA-B) OTNXFWY2 HLAB_HUMAN Decreases Expression [12]
HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1) OTRGGIFP DRB1_HUMAN Increases Expression [12]
Myelin basic protein (MBP) OTFZCEDB MBP_HUMAN Decreases Expression [12]
Fibronectin (FN1) OTB5ZN4Q FINC_HUMAN Increases Expression [12]
Albumin (ALB) OTVMM513 ALBU_HUMAN Decreases Expression [12]
Transferrin receptor protein 1 (TFRC) OT8ZPBDL TFR1_HUMAN Increases Expression [12]
Alpha-enolase (ENO1) OTB1KWJS ENOA_HUMAN Decreases Expression [12]
Transcription factor Sp1 (SP1) OTISPT4X SP1_HUMAN Decreases Expression [12]
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) OTIRPN6B ROA1_HUMAN Decreases Expression [12]
U2 small nuclear ribonucleoprotein A' (SNRPA1) OTWJZFAP RU2A_HUMAN Decreases Expression [12]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Increases Expression [12]
Chorionic somatomammotropin hormone 2 (CSH2) OTW8JVAN CSH2_HUMAN Decreases Expression [12]
Tissue factor pathway inhibitor (TFPI) OTA0FX16 TFPI1_HUMAN Decreases Expression [12]
Breakpoint cluster region protein (BCR) OTCN76C1 BCR_HUMAN Decreases Expression [12]
Interferon-induced transmembrane protein 1 (IFITM1) OTECO1G8 IFM1_HUMAN Increases Expression [12]
HLA class II histocompatibility antigen, DR beta 4 chain (HLA-DRB4) OTNXIHQU DRB4_HUMAN Increases Expression [12]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Decreases Expression [12]
Arylsulfatase B (ARSB) OTTYDDNU ARSB_HUMAN Decreases Expression [12]
Carboxypeptidase E (CPE) OTXNTV79 CBPE_HUMAN Increases Expression [12]
Integrin alpha-2 (ITGA2) OTPFL017 ITA2_HUMAN Increases Expression [12]
Gap junction alpha-1 protein (GJA1) OTT94MKL CXA1_HUMAN Affects Expression [12]
Peptidyl-glycine alpha-amidating monooxygenase (PAM) OTX8HV5B AMD_HUMAN Decreases Expression [12]
Glutathione hydrolase 1 proenzyme (GGT1) OTYDA1Z7 GGT1_HUMAN Decreases Expression [12]
Ras GTPase-activating protein 1 (RASA1) OTZJ3LP4 RASA1_HUMAN Decreases Expression [12]
Synaptotagmin-1 (SYT1) OTVTPOI6 SYT1_HUMAN Decreases Expression [12]
Receptor-type tyrosine-protein phosphatase gamma (PTPRG) OT9N2WOF PTPRG_HUMAN Decreases Expression [12]
Paired box protein Pax-7 (PAX7) OTDMQRPO PAX7_HUMAN Decreases Expression [12]
Annexin A13 (ANXA13) OTM33P73 ANX13_HUMAN Decreases Expression [12]
Lens fiber major intrinsic protein (MIP) OTEBLU3E MIP_HUMAN Decreases Expression [12]
Fibroblast growth factor 9 (FGF9) OT2SKDGM FGF9_HUMAN Decreases Expression [12]
Glycerol kinase (GK) OTK2YRA0 GLPK_HUMAN Decreases Expression [12]
Cystathionine gamma-lyase (CTH) OTC90LA0 CGL_HUMAN Increases Expression [12]
Myosin-10 (MYH10) OTXN2WXS MYH10_HUMAN Decreases Expression [12]
Large ribosomal subunit protein uL4 (RPL4) OTTYJB0X RL4_HUMAN Decreases Expression [12]
T-complex protein 1 subunit zeta (CCT6A) OTCYWL5F TCPZ_HUMAN Decreases Expression [12]
Reduced folate transporter (SLC19A1) OTWB0BTO S19A1_HUMAN Decreases Expression [12]
Matrin-3 (MATR3) OTESJ5S7 MATR3_HUMAN Decreases Expression [12]
Transcriptional regulator ATRX (ATRX) OT77RSQW ATRX_HUMAN Decreases Expression [12]
Vesicle-fusing ATPase (NSF) OTKRJ2ZT NSF_HUMAN Decreases Expression [12]
Stromal cell-derived factor 1 (CXCL12) OT2QX5LL SDF1_HUMAN Decreases Expression [12]
Nuclear pore complex protein Nup153 (NUP153) OTCAS0AR NU153_HUMAN Decreases Expression [12]
Gastrotropin (FABP6) OTIRQWLW FABP6_HUMAN Increases Expression [12]
Host cell factor 1 (HCFC1) OT0UCK62 HCFC1_HUMAN Decreases Expression [12]
Collagen alpha-4(IV) chain (COL4A4) OT9G0MCT CO4A4_HUMAN Decreases Expression [12]
Coatomer subunit alpha (COPA) OTZ1DTXU COPA_HUMAN Increases Expression [12]
Cadherin-4 (CDH4) OT8LH3HN CADH4_HUMAN Decreases Expression [12]
C-terminal-binding protein 2 (CTBP2) OTGZGT87 CTBP2_HUMAN Decreases Expression [12]
ADP-ribosylation factor-like protein 4C (ARL4C) OTQ3QNNU ARL4C_HUMAN Increases Expression [12]
Epiplakin (EPPK1) OT7BAU8C EPIPL_HUMAN Increases Expression [12]
Lysyl oxidase homolog 3 (LOXL3) OTLLY1QI LOXL3_HUMAN Decreases Expression [12]
Histone H4 (H4C1) OTB71W46 H4_HUMAN Decreases Expression [12]
AP-2 complex subunit beta (AP2B1) OTL6LZJ4 AP2B1_HUMAN Decreases Expression [12]
Hemoglobin subunit gamma-1 (HBG1) OTVL4NSU HBG1_HUMAN Decreases Expression [12]
Mothers against decapentaplegic homolog 3 (SMAD3) OTNA96MR SMAD3_HUMAN Decreases Expression [12]
ADP-ribosylation factor 1 (ARF1) OT5C4C3L ARF1_HUMAN Decreases Expression [12]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Affects Expression [12]
Clathrin heavy chain 1 (CLTC) OTBFASMA CLH1_HUMAN Decreases Expression [12]
Centromere-associated protein E (CENPE) OTQ7AP04 CENPE_HUMAN Decreases Expression [12]
Paired box protein Pax-5 (PAX5) OTYBJJWX PAX5_HUMAN Decreases Expression [12]
Dystonin (DST) OTHZBM4X DYST_HUMAN Decreases Expression [12]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Decreases Expression [12]
Recombining binding protein suppressor of hairless (RBPJ) OTD7CUG0 SUH_HUMAN Decreases Expression [12]
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) OT5GO2PL KHDR1_HUMAN Decreases Expression [12]
Protein phosphatase 3 catalytic subunit alpha (PPP3CA) OT58PUEN PP2BA_HUMAN Decreases Expression [12]
Leukocyte surface antigen CD47 (CD47) OTLDZ0KZ CD47_HUMAN Increases Expression [12]
Transmembrane protein 267 (TMEM267) OTEAAVK7 TM267_HUMAN Decreases Expression [12]
Proline-rich nuclear receptor coactivator 1 (PNRC1) OTQMLEE1 PNRC1_HUMAN Increases Expression [12]
Alpha-globin transcription factor CP2 (TFCP2) OTA246TE TFCP2_HUMAN Decreases Expression [12]
Disks large homolog 1 (DLG1) OTCRZYWT DLG1_HUMAN Decreases Expression [12]
Serine/threonine-protein kinase 4 (STK4) OTBRYNNH STK4_HUMAN Decreases Expression [12]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Decreases Expression [12]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) OT7TNF0L AAPK1_HUMAN Decreases Expression [12]
BMP and activin membrane-bound inhibitor homolog (BAMBI) OTCEJ8W5 BAMBI_HUMAN Increases Expression [12]
Dynactin subunit 2 (DCTN2) OTMB4IXD DCTN2_HUMAN Increases Expression [12]
Cullin-4A (CUL4A) OTTBV70J CUL4A_HUMAN Decreases Expression [12]
Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) OT5UO1FA HNRPD_HUMAN Decreases Expression [12]
Guanine nucleotide-binding protein subunit alpha-13 (GNA13) OTVDL515 GNA13_HUMAN Increases Expression [12]
Disco-interacting protein 2 homolog A (DIP2A) OTXPTR8R DIP2A_HUMAN Decreases Expression [12]
Uncharacterized protein KIAA0040 (KIAA0040) OT27EBY3 K0040_HUMAN Increases Expression [12]
Kinesin-like protein KIF14 (KIF14) OTXHT4JM KIF14_HUMAN Decreases Expression [12]
Transforming growth factor-beta-induced protein ig-h3 (TGFBI) OTR443C5 BGH3_HUMAN Decreases Expression [12]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Increases Expression [12]
MICOS complex subunit MIC60 (IMMT) OTBDSLE7 MIC60_HUMAN Affects Expression [12]
WD40 repeat-containing protein SMU1 (SMU1) OTLCSLGL SMU1_HUMAN Decreases Expression [12]
Neuroblastoma breakpoint family member 1 (NBPF1) OTAZ55UQ NBPF1_HUMAN Decreases Expression [12]
Cell adhesion molecule-related/down-regulated by oncogenes (CDON) OT81X593 CDON_HUMAN Decreases Expression [12]
Protein LBH (LBH) OT87AT1X LBH_HUMAN Decreases Expression [12]
Shugoshin 2 (SGO2) OTNGJDS8 SGO2_HUMAN Decreases Expression [12]
PAN2-PAN3 deadenylation complex subunit PAN3 (PAN3) OTYBA69S PAN3_HUMAN Decreases Expression [12]
Sterile alpha motif domain-containing protein 9 (SAMD9) OTDG48P0 SAMD9_HUMAN Increases Expression [12]
Serine/threonine-protein phosphatase 4 regulatory subunit 3B (PPP4R3B) OT1VTUL9 P4R3B_HUMAN Decreases Expression [12]
Acyl-coenzyme A thioesterase THEM4 (THEM4) OTSIZU8Y THEM4_HUMAN Decreases Expression [12]
MAGUK p55 subfamily member 7 (MPP7) OT3G3HTZ MPP7_HUMAN Increases Expression [12]
DDB1- and CUL4-associated factor 8 (DCAF8) OT3VFSLG DCAF8_HUMAN Decreases Expression [12]
Collagen alpha-1(XIII) chain (COL13A1) OTM9IM6J CODA1_HUMAN Increases Expression [12]
Probable E3 ubiquitin-protein ligase HECTD2 (HECTD2) OTDIBGQV HECD2_HUMAN Decreases Expression [12]
Serine/threonine-protein kinase MRCK alpha (CDC42BPA) OTCPFOSA MRCKA_HUMAN Decreases Expression [12]
Rho GTPase-activating protein SYDE2 (SYDE2) OTOEIXSM SYDE2_HUMAN Increases Expression [12]
Deubiquitinase MYSM1 (MYSM1) OTO73N00 MYSM1_HUMAN Decreases Expression [12]
AT-rich interactive domain-containing protein 2 (ARID2) OTIRJXWM ARID2_HUMAN Decreases Expression [12]
Glucose 1,6-bisphosphate synthase (PGM2L1) OTSBNRT5 PGM2L_HUMAN Increases Expression [12]
UPF0547 protein C16orf87 (C16ORF87) OT658H5A CP087_HUMAN Decreases Expression [12]
Kelch-like protein 24 (KLHL24) OTWZSX5C KLH24_HUMAN Increases Expression [12]
Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) OTV01EFP C1TM_HUMAN Decreases Expression [12]
Rho-related GTP-binding protein RhoU (RHOU) OTERIAD4 RHOU_HUMAN Increases Expression [12]
Protein ABHD13 (ABHD13) OTF2E8M6 ABHDD_HUMAN Decreases Expression [12]
G2/M phase-specific E3 ubiquitin-protein ligase (G2E3) OT06BFRQ G2E3_HUMAN Decreases Expression [12]
Diphthine--ammonia ligase (DPH6) OTOJ7BXR DPH6_HUMAN Decreases Expression [12]
Pogo transposable element with ZNF domain (POGZ) OT4CYWC1 POGZ_HUMAN Decreases Expression [12]
FERM domain-containing protein 5 (FRMD5) OTC73XJK FRMD5_HUMAN Decreases Expression [12]
Phosphatidylinositol-glycan biosynthesis class W protein (PIGW) OTT9SMTF PIGW_HUMAN Decreases Expression [12]
Amphoterin-induced protein 2 (AMIGO2) OTPAIT1O AMGO2_HUMAN Increases Expression [12]
Dihydrofolate reductase 2, mitochondrial (DHFR2) OTPHUWEY DYR2_HUMAN Decreases Expression [12]
ELKS/Rab6-interacting/CAST family member 1 (ERC1) OTYBGGNO RB6I2_HUMAN Decreases Expression [12]
Armadillo repeat-containing protein 8 (ARMC8) OTNAXGM7 ARMC8_HUMAN Decreases Expression [12]
Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3) OTNJX38T M4K3_HUMAN Decreases Expression [12]
Protein FAM219A (FAM219A) OTAFZHY9 F219A_HUMAN Decreases Expression [12]
Homeobox protein Mohawk (MKX) OT7H7Z50 MKX_HUMAN Decreases Expression [12]
Threonine synthase-like 1 (THNSL1) OTQNFH3E THNS1_HUMAN Decreases Expression [12]
Porimin (TMEM123) OTDMVZD6 PORIM_HUMAN Decreases Expression [12]
Rho guanine nucleotide exchange factor 39 (ARHGEF39) OT9UKTQ5 ARG39_HUMAN Decreases Expression [12]
Type 2 DNA topoisomerase 6 subunit B-like (TOP6BL) OTCYPUNK TO6BL_HUMAN Increases Expression [12]
Protein SCAI (SCAI) OTAK3TMO SCAI_HUMAN Decreases Expression [12]
Diacylglycerol lipase-beta (DAGLB) OT1S9869 DGLB_HUMAN Decreases Expression [12]
Regulator of G-protein signaling 22 (RGS22) OTCTFGW6 RGS22_HUMAN Decreases Expression [12]
Phospholipase DDHD1 (DDHD1) OTWTHOWK DDHD1_HUMAN Decreases Expression [12]
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) OTCV7AGV PCAT1_HUMAN Decreases Expression [12]
Biorientation of chromosomes in cell division protein 1-like 1 (BOD1L1) OTTD5FJ8 BD1L1_HUMAN Decreases Expression [12]
Atlastin-2 (ATL2) OT93AUOO ATLA2_HUMAN Increases Expression [12]
Centrosomal protein of 192 kDa (CEP192) OTBLFV7T CE192_HUMAN Decreases Expression [12]
DEP domain-containing protein 1B (DEPDC1B) OTMVFOT1 DEP1B_HUMAN Decreases Expression [12]
Pleckstrin homology-like domain family A member 1 (PHLDA1) OTFTWMIQ PHLA1_HUMAN Decreases Expression [12]
Microprocessor complex subunit DGCR8 (DGCR8) OT62LXE4 DGCR8_HUMAN Decreases Expression [12]
Tribbles homolog 2 (TRIB2) OTHSX3MX TRIB2_HUMAN Affects Expression [12]
Protein FAM3C (FAM3C) OTBR6U9G FAM3C_HUMAN Decreases Expression [12]
CREB-binding protein (CREBBP) OTPA4QGM CBP_HUMAN Decreases Expression [12]
Histone acetyltransferase KAT2B (KAT2B) OTWQITWK KAT2B_HUMAN Increases Expression [12]
Homeobox protein DLX-4 (DLX4) OTLWVCN4 DLX4_HUMAN Increases Expression [12]
Protein tyrosine phosphatase type IVA 1 (PTP4A1) OTK0NFXJ TP4A1_HUMAN Decreases Expression [12]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Increases Expression [12]
Exocyst complex component 4 (EXOC4) OT5EWXAN EXOC4_HUMAN Decreases Expression [12]
RalBP1-associated Eps domain-containing protein 1 (REPS1) OTX4ERRK REPS1_HUMAN Decreases Expression [12]
Protein LTV1 homolog (LTV1) OTZILJDI LTV1_HUMAN Decreases Expression [12]
PDZ and LIM domain protein 5 (PDLIM5) OTLQVV22 PDLI5_HUMAN Decreases Expression [12]
DISP complex protein LRCH3 (LRCH3) OTDLBLMU LRCH3_HUMAN Decreases Expression [12]
Rho GTPase-activating protein 7 (DLC1) OTP8LMCR RHG07_HUMAN Decreases Expression [12]
Tribbles homolog 1 (TRIB1) OTPEO17G TRIB1_HUMAN Increases Expression [12]
Mitochondrial inner membrane protease subunit 2 (IMMP2L) OT9WGAFD IMP2L_HUMAN Decreases Expression [12]
Transcription factor 12 (TCF12) OTZVONNU HTF4_HUMAN Decreases Expression [12]
ATP synthase subunit s, mitochondrial (DMAC2L) OT2OQ1UD ATP5S_HUMAN Decreases Expression [12]
Semaphorin-3C (SEMA3C) OTEGUY7F SEM3C_HUMAN Increases Expression [12]
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (DPH2) OT9P91XR DPH2_HUMAN Decreases Expression [12]
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) OTB78IF4 ODC_HUMAN Decreases Expression [12]
Deubiquitinase DESI2 (DESI2) OTHUOKOC DESI2_HUMAN Decreases Expression [12]
Acireductone dioxygenase (ADI1) OT8IOD03 MTND_HUMAN Decreases Expression [12]
Protein C1orf43 (C1ORF43) OTT9CVZR CA043_HUMAN Decreases Expression [12]
RNA-binding protein 24 (RBM24) OTQI1AR1 RBM24_HUMAN Increases Expression [12]
Nucleolar and spindle-associated protein 1 (NUSAP1) OT85HIJ5 NUSAP_HUMAN Decreases Expression [12]
E3 ubiquitin-protein ligase TRIM9 (TRIM9) OTKYG33W TRIM9_HUMAN Increases Expression [12]
E3 ubiquitin-protein ligase TRIM4 (TRIM4) OTLKQNKQ TRIM4_HUMAN Increases Expression [12]
Histone-lysine N-methyltransferase SETD5 (SETD5) OTRPAVEO SETD5_HUMAN Decreases Expression [12]
Alpha-ketoglutarate-dependent dioxygenase FTO (FTO) OTXML85Y FTO_HUMAN Decreases Expression [12]
Centrosomal protein of 295 kDa (CEP295) OTVTTXRO CE295_HUMAN Decreases Expression [12]
Sentrin-specific protease 6 (SENP6) OT05LLF4 SENP6_HUMAN Decreases Expression [12]
Cytochrome c oxidase assembly factor 1 homolog (COA1) OTHSX40F COA1_HUMAN Decreases Expression [12]
Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19) OTH88TXU ADA19_HUMAN Increases Expression [12]
Pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2) OTXV0ZD0 PHS2_HUMAN Decreases Expression [12]
Metal transporter CNNM2 (CNNM2) OTZHO8WU CNNM2_HUMAN Increases Expression [12]
Pleckstrin homology domain-containing family A member 5 (PLEKHA5) OT2MNW8T PKHA5_HUMAN Decreases Expression [12]
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) OTQDHSMI MCCB_HUMAN Decreases Expression [12]
E3 ubiquitin-protein ligase SMURF1 (SMURF1) OT5UIZR8 SMUF1_HUMAN Affects Expression [12]
Large ribosomal subunit protein mL65 (MRPS30) OTDXIAGG RT30_HUMAN Decreases Expression [12]
Transcription factor 7-like 2 (TCF7L2) OTVWPZ8B TF7L2_HUMAN Decreases Expression [12]
Muscleblind-like protein 1 (MBNL1) OTOV7J85 MBNL1_HUMAN Decreases Expression [12]
Lymphoid-specific helicase (HELLS) OTVVV668 HELLS_HUMAN Decreases Expression [12]
Phenylalanine--tRNA ligase beta subunit (FARSB) OT8N9TT5 SYFB_HUMAN Decreases Expression [12]
Midasin (MDN1) OTNBSPTW MDN1_HUMAN Affects Expression [12]
tRNA:m(4)X modification enzyme TRM13 homolog (TRMT13) OT2H0MCE TRM13_HUMAN Decreases Expression [12]
E3 ubiquitin-protein ligase RLIM (RLIM) OTEBRNHJ RNF12_HUMAN Decreases Expression [12]
G patch domain-containing protein 2-like (GPATCH2L) OTETUZ64 GPT2L_HUMAN Decreases Expression [12]
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1) OTFOJUIQ PHAG1_HUMAN Increases Expression [12]
Huntingtin-interacting protein K (HYPK) OTRWRVWN HYPK_HUMAN Affects Expression [12]
Inhibitor of growth protein 3 (ING3) OTDIJXFP ING3_HUMAN Decreases Expression [12]
Rho guanine nucleotide exchange factor 12 (ARHGEF12) OTM2D3LT ARHGC_HUMAN Decreases Expression [12]
Cysteine-rich motor neuron 1 protein (CRIM1) OTTZNV6Y CRIM1_HUMAN Decreases Expression [12]
Voltage-dependent T-type calcium channel subunit alpha-1I (CACNA1I) OTRH8X8A CAC1I_HUMAN Decreases Expression [12]
eIF-2-alpha kinase GCN2 (EIF2AK4) OTLE1JY8 E2AK4_HUMAN Affects Expression [12]
DNA polymerase kappa (POLK) OTKZ38JH POLK_HUMAN Decreases Expression [12]
Mediator of RNA polymerase II transcription subunit 13 (MED13) OTP5LEJE MED13_HUMAN Decreases Expression [12]
Jupiter microtubule associated homolog 1 (JPT1) OT6CRZEU JUPI1_HUMAN Decreases Expression [12]
BTB/POZ domain-containing protein 3 (BTBD3) OTZ607YT BTBD3_HUMAN Decreases Expression [12]
Thyroid hormone receptor-associated protein 3 (THRAP3) OTG25JOG TR150_HUMAN Decreases Expression [12]
rRNA-processing protein FCF1 homolog (FCF1) OTTI9M2D FCF1_HUMAN Affects Expression [12]
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMHD1) OTBCIBC7 SAMH1_HUMAN Affects Expression [12]
Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (HS3ST3B1) OTK53GUD HS3SB_HUMAN Increases Expression [12]
Calcineurin-binding protein cabin-1 (CABIN1) OT4G5CIK CABIN_HUMAN Decreases Expression [12]
Proton-coupled zinc antiporter SLC30A1 (SLC30A1) OTY8J0S4 ZNT1_HUMAN Decreases Expression [12]
Serine/threonine-protein kinase Chk1 (CHEK1) OTTTI622 CHK1_HUMAN Increases Phosphorylation [35]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [36]
Ubiquinone biosynthesis protein COQ9, mitochondrial (COQ9) OTM2T1FI COQ9_HUMAN Decreases Expression [14]
Interleukin-33 (IL33) OTT5YWK3 IL33_HUMAN Increases Expression [37]
Serine/threonine-protein kinase Chk2 (CHEK2) OT8ZPCNS CHK2_HUMAN Increases Phosphorylation [38]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Increases Expression [37]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Decreases Secretion [39]
Protransforming growth factor alpha (TGFA) OTPD1LL9 TGFA_HUMAN Increases Secretion [40]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Expression [41]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Expression [38]
Protein kinase C beta type (PRKCB) OTYQ0656 KPCB_HUMAN Increases Phosphorylation [40]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Affects Expression [42]
DNA excision repair protein ERCC-1 (ERCC1) OTNPYQHI ERCC1_HUMAN Decreases Expression [13]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [37]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Expression [43]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [40]
Amphiregulin (AREG) OTJFOR67 AREG_HUMAN Increases Expression [40]
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Decreases Expression [44]
Protein kinase C alpha type (PRKCA) OT5UWNRD KPCA_HUMAN Increases Phosphorylation [40]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Increases Activity [41]
3-mercaptopyruvate sulfurtransferase (MPST) OTCDPH5D THTM_HUMAN Decreases Expression [14]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [45]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Increases Expression [14]
Nitric oxide synthase, inducible (NOS2) OTKKIOJ1 NOS2_HUMAN Increases Expression [37]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Decreases Expression [37]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [46]
Protein kinase C iota type (PRKCI) OTKBAVT3 KPCI_HUMAN Increases Phosphorylation [40]
Signal transducer and activator of transcription 1-alpha/beta (STAT1) OTLMBUZ6 STAT1_HUMAN Increases Phosphorylation [45]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [47]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Decreases Expression [48]
Radiation-inducible immediate-early gene IEX-1 (IER3) OTZJI5FZ IEX1_HUMAN Increases Expression [14]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Activity [36]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [38]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Decreases Expression [49]
Rho-related GTP-binding protein RhoB (RHOB) OTHQFQF7 RHOB_HUMAN Increases Expression [14]
DNA-dependent protein kinase catalytic subunit (PRKDC) OTJVS4EG PRKDC_HUMAN Increases Phosphorylation [50]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Increases Activity [41]
Protein kinase C delta type (PRKCD) OTSEH90E KPCD_HUMAN Increases Phosphorylation [40]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Increases Expression [51]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [48]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Increases Phosphorylation [38]
Transcription factor HES-1 (HES1) OT8P19W2 HES1_HUMAN Increases Activity [52]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Activity [48]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Increases Expression [37]
Extracellular tyrosine-protein kinase PKDCC (PKDCC) OTVXJR26 PKDCC_HUMAN Decreases Expression [14]
Pleckstrin homology-like domain family A member 2 (PHLDA2) OTMV9DPP PHLA2_HUMAN Increases Expression [14]
Docking protein 6 (DOK6) OTX55OIF DOK6_HUMAN Decreases Expression [14]
tRNA-splicing endonuclease subunit Sen2 (TSEN2) OT1UWYRI SEN2_HUMAN Decreases Expression [14]
Protein FAN (NSMAF) OTYNVZ23 FAN_HUMAN Decreases Expression [14]
Probable ATP-dependent RNA helicase DDX17 (DDX17) OTXRMMBP DDX17_HUMAN Decreases Expression [14]
F-box/WD repeat-containing protein 5 (FBXW5) OT5TQK3H FBXW5_HUMAN Increases Expression [14]
PRKC apoptosis WT1 regulator protein (PAWR) OTKY7W52 PAWR_HUMAN Decreases Expression [14]
Proheparin-binding EGF-like growth factor (HBEGF) OTLU00JS HBEGF_HUMAN Increases Expression [40]
Homeobox protein HMX1 (HMX1) OT65ZGE0 HMX1_HUMAN Increases Expression [14]
Abl interactor 2 (ABI2) OT8GIIS5 ABI2_HUMAN Decreases Expression [14]
Inhibitor of Bruton tyrosine kinase (IBTK) OTB2GM4G IBTK_HUMAN Decreases Expression [14]
SERTA domain-containing protein 1 (SERTAD1) OTBHKZQP SRTD1_HUMAN Increases Expression [14]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Decreases Response To Substance [53]
Phospholipid phosphatase 1 (PLPP1) OT0IIMI5 PLPP1_HUMAN Decreases Response To Substance [53]
DNA polymerase alpha catalytic subunit (POLA1) OT1WXFVY DPOLA_HUMAN Increases Response To Substance [53]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Response To Substance [54]
Collagen alpha-1(VII) chain (COL7A1) OT3MIRZJ CO7A1_HUMAN Decreases Response To Substance [53]
Integrin alpha-E (ITGAE) OT41KCRX ITAE_HUMAN Increases Response To Substance [53]
Nicastrin (NCSTN) OT5QBTA4 NICA_HUMAN Affects Response To Substance [52]
V-type proton ATPase 21 kDa proteolipid subunit c'' (ATP6V0B) OT8GTI1V VATO_HUMAN Increases Response To Substance [53]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Affects Response To Substance [55]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1) OT9HYT7A PLCB1_HUMAN Increases ADR [56]
DNA polymerase epsilon subunit 2 (POLE2) OTAC9V6L DPOE2_HUMAN Increases Response To Substance [53]
Protein DBF4 homolog A (DBF4) OTBL7JHQ DBF4A_HUMAN Increases Response To Substance [53]
Glucocorticoid receptor (NR3C1) OTCI2YDI GCR_HUMAN Decreases Response To Substance [53]
Cell division cycle protein 20 homolog (CDC20) OTCOEZRV CDC20_HUMAN Increases Response To Substance [53]
RNA-binding motif, single-stranded-interacting protein 1 (RBMS1) OTD13PJN RBMS1_HUMAN Decreases Response To Substance [53]
S-phase kinase-associated protein 2 (SKP2) OTD5B41X SKP2_HUMAN Increases Response To Substance [53]
Pre-B-cell leukemia transcription factor-interacting protein 1 (PBXIP1) OTEAAUBY PBIP1_HUMAN Decreases Response To Substance [53]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Increases Response To Substance [57]
DNA mismatch repair protein Mlh1 (MLH1) OTG5XDD8 MLH1_HUMAN Affects Response To Substance [55]
Origin recognition complex subunit 1 (ORC1) OTHWU8IJ ORC1_HUMAN Increases Response To Substance [53]
U6 snRNA-associated Sm-like protein LSm7 (LSM7) OTHZ2XPX LSM7_HUMAN Increases Response To Substance [53]
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) OTJC60Q7 THIL_HUMAN Increases Response To Substance [53]
Transcriptional activator Myb (MYB) OTJH64IV MYB_HUMAN Increases Response To Substance [53]
CCN family member 1 (CCN1) OTKJBEMD CCN1_HUMAN Decreases Response To Substance [53]
Ras-related protein Rab-31 (RAB31) OTMLXQZ0 RAB31_HUMAN Decreases Response To Substance [53]
Copper-transporting ATPase 1 (ATP7A) OTMR3GXP ATP7A_HUMAN Decreases Response To Substance [58]
Plasma membrane calcium-transporting ATPase 4 (ATP2B4) OTMWFDAC AT2B4_HUMAN Decreases Response To Substance [53]
E3 ubiquitin-protein ligase CCNB1IP1 (CCNB1IP1) OTOTVMC8 CIP1_HUMAN Increases Response To Substance [53]
Protein FAM50B (FAM50B) OTP3H38A FA50B_HUMAN Increases ADR [59]
DNA fragmentation factor subunit beta (DFFB) OTPBW5N5 DFFB_HUMAN Increases Response To Substance [53]
ATP-binding cassette sub-family B member 6 (ABCB6) OTPGZFES ABCB6_HUMAN Decreases Response To Substance [60]
E3 ubiquitin-protein ligase RNF34 (RNF34) OTQY58LU RNF34_HUMAN Decreases Response To Substance [47]
DNA-directed RNA polymerase III subunit RPC7 (POLR3G) OTU3TGQ9 RPC7_HUMAN Increases Response To Substance [53]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Response To Substance [61]
NADPH--cytochrome P450 reductase (POR) OTVIDOCH NCPR_HUMAN Increases Response To Substance [30]
Protein NDRG1 (NDRG1) OTVO66BO NDRG1_HUMAN Decreases Response To Substance [62]
Phosphoserine aminotransferase (PSAT1) OTVV1YV9 SERC_HUMAN Increases Response To Substance [53]
Uncharacterized protein C8orf34 (C8ORF34) OTXCTHDG CH034_HUMAN Increases ADR [56]
Small nuclear ribonucleoprotein F (SNRPF) OTZE5W6G RUXF_HUMAN Increases Response To Substance [53]
Adenylate kinase 2, mitochondrial (AK2) OTZG3X2H KAD2_HUMAN Increases Response To Substance [53]
------------------------------------------------------------------------------------
⏷ Show the Full List of 469 DOT(s)
Indication(s) of DTI-015
Disease Entry ICD 11 Status REF
Brain cancer 2A00 Approved [4]
Glioblastoma of brain 2A00.00 Approved [5]
Liver cancer 2C12 Approved [6]
Malignant glioma 2A00.0 Approved [7]
Plasma cell myeloma 2A83.1 Approved [8]
Classic Hodgkin lymphoma N.A. Investigative [8]
DTI-015 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Binder [6]
------------------------------------------------------------------------------------
DTI-015 Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [66]
Glutathione S-transferase alpha-1 (GSTA1) DE4ZHS1 GSTA1_HUMAN Metabolism [67]
------------------------------------------------------------------------------------
DTI-015 Interacts with 386 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Decreases Response To Substance [64]
Probable G-protein coupled receptor 25 (GPR25) OTXTNEW3 GPR25_HUMAN Decreases Expression [63]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) OTQ4W7MT TR11B_HUMAN Decreases Expression [63]
Ladinin-1 (LAD1) OT6YGTVX LAD1_HUMAN Decreases Expression [63]
Immunoglobulin superfamily containing leucine-rich repeat protein (ISLR) OTOLYLGI ISLR_HUMAN Decreases Expression [63]
Homeobox protein CDX-4 (CDX4) OTD1SQKM CDX4_HUMAN Decreases Expression [63]
Segment polarity protein dishevelled homolog DVL-1 (DVL1) OTD67RF1 DVL1_HUMAN Decreases Expression [63]
Tetraspanin-4 (TSPAN4) OTKFK57F TSN4_HUMAN Decreases Expression [63]
Actin-related protein 2/3 complex subunit 2 (ARPC2) OTSOKOMY ARPC2_HUMAN Decreases Expression [63]
Short stature homeobox protein (SHOX) OTE0YZJO SHOX_HUMAN Decreases Expression [63]
Polyunsaturated fatty acid lipoxygenase ALOX15B (ALOX15B) OTWQQ08W LX15B_HUMAN Decreases Expression [63]
Prosaposin receptor GPR37 (GPR37) OTIMDDI3 GPR37_HUMAN Decreases Expression [63]
Protein phosphatase 1G (PPM1G) OTLZL9CG PPM1G_HUMAN Decreases Expression [63]
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1) OTCDAVBQ SHIP2_HUMAN Decreases Expression [63]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Decreases Expression [63]
Beta-1,4-galactosyltransferase 5 (B4GALT5) OTHMZY12 B4GT5_HUMAN Decreases Expression [63]
NADH dehydrogenase 1 subunit C1, mitochondrial (NDUFC1) OTJ5TNHB NDUC1_HUMAN Decreases Expression [63]
Transcription factor 21 (TCF21) OT393IMA TCF21_HUMAN Decreases Expression [63]
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (DHX16) OTW8KZAU DHX16_HUMAN Decreases Expression [63]
LIM homeobox transcription factor 1-beta (LMX1B) OTM8145D LMX1B_HUMAN Decreases Expression [63]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2) OTG7NW98 F262_HUMAN Decreases Expression [63]
Sphingomyelin phosphodiesterase 2 (SMPD2) OTE5BVP9 NSMA_HUMAN Increases Expression [63]
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) OT4CA13K ATS4_HUMAN Decreases Expression [63]
Probable G-protein coupled receptor 32 (GPR32) OTTWHSP9 GPR32_HUMAN Decreases Expression [63]
Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4) OTJFA4AV LRCH4_HUMAN Decreases Expression [63]
Gamma-synuclein (SNCG) OT3CPI8L SYUG_HUMAN Increases Expression [63]
Extracellular matrix protein 2 (ECM2) OTNGYVMR ECM2_HUMAN Increases Expression [63]
Aquaporin-8 (AQP8) OT99JKME AQP8_HUMAN Decreases Expression [63]
BAI1-associated protein 3 (BAIAP3) OTS1H0J0 BAIP3_HUMAN Decreases Expression [63]
Sorbin and SH3 domain-containing protein 2 (SORBS2) OTJSX44Y SRBS2_HUMAN Decreases Expression [63]
Homeobox protein Nkx-2.2 (NKX2-2) OTDCOYNG NKX22_HUMAN Decreases Expression [63]
Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein (ASMTL) OTPUGCZO ASML_HUMAN Decreases Expression [63]
Adenomatous polyposis coli protein 2 (APC2) OTRH91CX APCL_HUMAN Decreases Expression [63]
B-cell lymphoma/leukemia 10 (BCL10) OT47MCLI BCL10_HUMAN Increases Expression [63]
Prolactin (PRL) OTWFQGX7 PRL_HUMAN Decreases Expression [63]
Gastrin (GAST) OTD0IP9N GAST_HUMAN Decreases Expression [63]
Ferritin light chain (FTL) OTYQA8A6 FRIL_HUMAN Decreases Expression [63]
Ferritin heavy chain (FTH1) OT6IFS0O FRIH_HUMAN Decreases Expression [63]
Muellerian-inhibiting factor (AMH) OT5FH4BD MIS_HUMAN Decreases Expression [63]
Protamine-2 (PRM2) OTSAXTSQ PRM2_HUMAN Decreases Expression [63]
Non-histone chromosomal protein HMG-17 (HMGN2) OTN20MEF HMGN2_HUMAN Decreases Expression [63]
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Decreases Expression [63]
Creatine kinase M-type (CKM) OTME0KO7 KCRM_HUMAN Decreases Expression [63]
Epoxide hydrolase 1 (EPHX1) OTBKWQER HYEP_HUMAN Decreases Expression [63]
Acetylcholine receptor subunit gamma (CHRNG) OTXC2UR7 ACHG_HUMAN Decreases Expression [63]
Profilin-1 (PFN1) OTHTGA1H PROF1_HUMAN Decreases Expression [63]
Muscarinic acetylcholine receptor M4 (CHRM4) OTF0F0FF ACM4_HUMAN Decreases Expression [63]
ATP-dependent 6-phosphofructokinase, muscle type (PFKM) OT1QY9JM PFKAM_HUMAN Decreases Expression [63]
U2 small nuclear ribonucleoprotein B'' (SNRPB2) OT6XISJD RU2B_HUMAN Increases Expression [63]
Steryl-sulfatase (STS) OTXTJQPC STS_HUMAN Increases Expression [63]
Glycodelin (PAEP) OTQA0NV4 PAEP_HUMAN Decreases Expression [63]
Steroid hormone receptor ERR1 (ESRRA) OTTDTUSP ERR1_HUMAN Increases Expression [63]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Decreases Expression [63]
B-cell antigen receptor complex-associated protein alpha chain (CD79A) OTOJC8DV CD79A_HUMAN Decreases Expression [63]
Alpha-actinin-1 (ACTN1) OTUCLNXH ACTN1_HUMAN Decreases Expression [63]
Platelet glycoprotein Ib beta chain (GP1BB) OTD7XNLL GP1BB_HUMAN Decreases Expression [63]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Increases Expression [63]
Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3) OTM8EG6H AT1A3_HUMAN Decreases Expression [63]
Delta-aminolevulinic acid dehydratase (ALAD) OTHM9GSH HEM2_HUMAN Decreases Expression [63]
Glial fibrillary acidic protein (GFAP) OTQ01ZAS GFAP_HUMAN Decreases Expression [63]
Myoblast determination protein 1 (MYOD1) OTV2S79X MYOD1_HUMAN Decreases Expression [63]
Myogenin (MYOG) OTPLJKFA MYOG_HUMAN Decreases Expression [63]
Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) OT7US3NO SIAT1_HUMAN Increases Expression [63]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Decreases Expression [63]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Decreases Expression [63]
Bone morphogenetic protein 7 (BMP7) OTYATP2K BMP7_HUMAN Decreases Expression [63]
Pituitary adenylate cyclase-activating polypeptide (ADCYAP1) OT0LQH93 PACA_HUMAN Decreases Expression [63]
DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) OTH5IL2A RPAB1_HUMAN Decreases Expression [63]
Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) OTSXJGQF ITIH1_HUMAN Decreases Expression [63]
Protachykinin-1 (TAC1) OTM842YW TKN1_HUMAN Decreases Expression [63]
Hepatocyte nuclear factor 1-alpha (HNF1A) OT9DOUKL HNF1A_HUMAN Decreases Expression [63]
Collagen alpha-1(IX) chain (COL9A1) OTWBR27Y CO9A1_HUMAN Decreases Expression [63]
Midkine (MDK) OTF24HKC MK_HUMAN Decreases Expression [63]
Macrophage scavenger receptor types I and II (MSR1) OTHANJ7A MSRE_HUMAN Decreases Expression [63]
Iduronate 2-sulfatase (IDS) OTZO94EO IDS_HUMAN Decreases Expression [63]
Calretinin (CALB2) OTSNMCG9 CALB2_HUMAN Decreases Expression [63]
Splicing factor, proline- and glutamine-rich (SFPQ) OTLCIAPJ SFPQ_HUMAN Decreases Expression [63]
Carbonic anhydrase 6 (CA6) OTIX56CJ CAH6_HUMAN Decreases Expression [63]
Sodium-dependent noradrenaline transporter (SLC6A2) OTMHQJMP SC6A2_HUMAN Increases Expression [63]
Integrin alpha-3 (ITGA3) OTBCH21D ITA3_HUMAN Decreases Expression [63]
Tyrosine-protein phosphatase non-receptor type 3 (PTPN3) OTSLZBVY PTN3_HUMAN Decreases Expression [63]
Elongation factor 1-gamma (EEF1G) OTW7DH2F EF1G_HUMAN Increases Expression [63]
V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C) OTKPL09B VATL_HUMAN Decreases Expression [63]
Cystatin-D (CST5) OTHJXNJG CYTD_HUMAN Decreases Expression [63]
Progranulin (GRN) OTXXSJ53 GRN_HUMAN Decreases Expression [63]
Cellular retinoic acid-binding protein 1 (CRABP1) OTISDG5X RABP1_HUMAN Decreases Expression [63]
ATP synthase subunit delta, mitochondrial (ATP5F1D) OTXTAG2V ATPD_HUMAN Decreases Expression [63]
Gonadotropin-releasing hormone receptor (GNRHR) OTLE25K3 GNRHR_HUMAN Increases Expression [63]
Rab GDP dissociation inhibitor alpha (GDI1) OTYM3928 GDIA_HUMAN Increases Expression [63]
RAC-beta serine/threonine-protein kinase (AKT2) OTBB632K AKT2_HUMAN Decreases Expression [63]
T-lymphocyte activation antigen CD80 (CD80) OTJBLUQE CD80_HUMAN Increases Expression [63]
Ribonuclease 4 (RNASE4) OTA5SZLC RNAS4_HUMAN Increases Expression [63]
Macrosialin (CD68) OTOYEY3J CD68_HUMAN Decreases Expression [63]
Serine hydroxymethyltransferase, mitochondrial (SHMT2) OT5NCAZN GLYM_HUMAN Decreases Expression [63]
General transcription factor IIF subunit 1 (GTF2F1) OTVXS75P T2FA_HUMAN Decreases Expression [63]
Small proline-rich protein 2B (SPRR2B) OTQ9WPKY SPR2B_HUMAN Decreases Expression [63]
Alpha-1B adrenergic receptor (ADRA1B) OTSAYAFD ADA1B_HUMAN Decreases Expression [63]
Apelin receptor (APLNR) OT8585HU APJ_HUMAN Decreases Expression [63]
Fibrillin-1 (FBN1) OTYCJT63 FBN1_HUMAN Decreases Expression [63]
Insulin receptor substrate 1 (IRS1) OTNO82CU IRS1_HUMAN Decreases Expression [63]
Monocarboxylate transporter 8 (SLC16A2) OTLRA7C0 MOT8_HUMAN Increases Expression [63]
Signal recognition particle 14 kDa protein (SRP14) OTAVZ94Y SRP14_HUMAN Decreases Expression [63]
Vasopressin V1a receptor (AVPR1A) OTKR8AFL V1AR_HUMAN Increases Expression [63]
Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) OTZG1W8W CEAM3_HUMAN Decreases Expression [63]
Pre-B-cell leukemia transcription factor 2 (PBX2) OTEBYCAW PBX2_HUMAN Decreases Expression [63]
Carnitine O-acetyltransferase (CRAT) OTSCLZ04 CACP_HUMAN Decreases Expression [63]
Radiation-inducible immediate-early gene IEX-1 (IER3) OTZJI5FZ IEX1_HUMAN Decreases Expression [63]
Solute carrier organic anion transporter family member 1A2 (SLCO1A2) OTO70C5O SO1A2_HUMAN Decreases Expression [63]
RPE-retinal G protein-coupled receptor (RGR) OTKCF5AZ RGR_HUMAN Decreases Expression [63]
Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2) OT9TZ2E0 GBRA2_HUMAN Decreases Expression [63]
Olfactory marker protein (OMP) OT7JH0DY OMP_HUMAN Decreases Expression [63]
Neuropeptides B/W receptor type 2 (NPBWR2) OTABA9JW NPBW2_HUMAN Decreases Expression [63]
CD151 antigen (CD151) OTF3UZS7 CD151_HUMAN Decreases Expression [63]
Cyclin-dependent kinase 8 (CDK8) OTMC3CWX CDK8_HUMAN Decreases Expression [63]
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA) OTCV2Q89 FNTA_HUMAN Decreases Expression [63]
Choline-phosphate cytidylyltransferase A (PCYT1A) OTMH0YLN PCY1A_HUMAN Decreases Expression [63]
Rab GDP dissociation inhibitor beta (GDI2) OTGLY3I7 GDIB_HUMAN Increases Expression [63]
Potassium-transporting ATPase subunit beta (ATP4B) OTIP2EYJ ATP4B_HUMAN Decreases Expression [63]
Tyrosine-protein kinase Blk (BLK) OT1EB8MT BLK_HUMAN Decreases Expression [63]
Insulin-like 3 (INSL3) OT7KUNTE INSL3_HUMAN Decreases Expression [63]
Host cell factor 1 (HCFC1) OT0UCK62 HCFC1_HUMAN Decreases Expression [63]
Diphosphomevalonate decarboxylase (MVD) OTGEX4SR MVD1_HUMAN Decreases Expression [63]
Beta-crystallin B1 (CRYBB1) OTDI4W3V CRBB1_HUMAN Decreases Expression [63]
Clathrin heavy chain 2 (CLTCL1) OT6W5BNR CLH2_HUMAN Increases Expression [63]
Mitogen-activated protein kinase 10 (MAPK10) OTC46VX1 MK10_HUMAN Decreases Expression [63]
UV excision repair protein RAD23 homolog A (RAD23A) OTBPAWHX RD23A_HUMAN Decreases Expression [63]
Eukaryotic translation initiation factor 6 (EIF6) OTEXMUED IF6_HUMAN Decreases Expression [63]
Syntaxin-1B (STX1B) OTSW59X0 STX1B_HUMAN Decreases Expression [63]
Pterin-4-alpha-carbinolamine dehydratase (PCBD1) OTDSRUD5 PHS_HUMAN Decreases Expression [63]
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) OT6285L4 FKB1A_HUMAN Decreases Expression [63]
Actin, gamma-enteric smooth muscle (ACTG2) OTRDWUO0 ACTH_HUMAN Decreases Expression [63]
Actin, alpha cardiac muscle 1 (ACTC1) OTJU04B1 ACTC_HUMAN Decreases Expression [63]
Contactin-associated protein 1 (CNTNAP1) OT5Y03EU CNTP1_HUMAN Increases Expression [63]
Homeobox protein Hox-A4 (HOXA4) OTNVTQDT HXA4_HUMAN Decreases Expression [63]
S-adenosylmethionine synthase isoform type-1 (MAT1A) OTK72E4F METK1_HUMAN Decreases Expression [63]
Cytochrome c oxidase subunit 6A2, mitochondrial (COX6A2) OTQR5SXD CX6A2_HUMAN Decreases Expression [63]
Mucin-2 (MUC2) OT3X4QVX MUC2_HUMAN Decreases Expression [63]
Keratin, type I cytoskeletal 17 (KRT17) OT6Y1DPK K1C17_HUMAN Decreases Expression [63]
Transducin-like enhancer protein 3 (TLE3) OTR9PH95 TLE3_HUMAN Decreases Expression [63]
Sex-determining region Y protein (SRY) OT516T6D SRY_HUMAN Decreases Expression [63]
Neuronal acetylcholine receptor subunit beta-3 (CHRNB3) OTE5XENW ACHB3_HUMAN Decreases Expression [63]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Decreases Expression [63]
Paired box protein Pax-8 (PAX8) OTRPD9MI PAX8_HUMAN Decreases Expression [63]
Golgin subfamily A member 2 (GOLGA2) OT5S9KYM GOGA2_HUMAN Decreases Expression [63]
Lysyl oxidase homolog 1 (LOXL1) OTA0NEJU LOXL1_HUMAN Decreases Expression [63]
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (MGAT3) OTXI5X4T MGAT3_HUMAN Decreases Expression [63]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Decreases Expression [63]
Kinesin heavy chain isoform 5A (KIF5A) OT3ETTI6 KIF5A_HUMAN Decreases Expression [63]
Mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2) OTM7V78U M4K2_HUMAN Decreases Expression [63]
Inositol 1,4,5-triphosphate receptor associated 2 (IRAG2) OTLUTKJQ IRAG2_HUMAN Decreases Expression [63]
TNF receptor-associated factor 1 (TRAF1) OTTLM5RU TRAF1_HUMAN Decreases Expression [63]
Myosin-binding protein H (MYBPH) OTQJBPUR MYBPH_HUMAN Decreases Expression [63]
Golgin subfamily A member 4 (GOLGA4) OTCMEHNJ GOGA4_HUMAN Increases Expression [63]
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15) OTZ7VLTP ADA15_HUMAN Decreases Expression [63]
Laminin subunit beta-3 (LAMB3) OTFPU6W8 LAMB3_HUMAN Decreases Expression [63]
Translation initiation factor eIF2B subunit alpha (EIF2B1) OT4NCVY1 EI2BA_HUMAN Increases Expression [63]
Guanidinoacetate N-methyltransferase (GAMT) OTVC87ES GAMT_HUMAN Decreases Expression [63]
Growth factor receptor-bound protein 7 (GRB7) OTF8Y9XY GRB7_HUMAN Decreases Expression [63]
Beclin-1 (BECN1) OT4X293M BECN1_HUMAN Decreases Expression [63]
Hepatic sodium/bile acid cotransporter (SLC10A1) OTUJVMCL NTCP_HUMAN Increases Expression [63]
Procollagen C-endopeptidase enhancer 1 (PCOLCE) OTJXOAN4 PCOC1_HUMAN Decreases Expression [63]
Reticulocalbin-1 (RCN1) OT3JBGAG RCN1_HUMAN Decreases Expression [63]
Keratin, type I cuticular Ha1 (KRT31) OTB6RCAH K1H1_HUMAN Decreases Expression [63]
Cytohesin-1 (CYTH1) OTYH9NRJ CYH1_HUMAN Increases Expression [63]
Mediator of RNA polymerase II transcription subunit 1 (MED1) OTOO24C4 MED1_HUMAN Decreases Expression [63]
Striated muscle preferentially expressed protein kinase (SPEG) OTQXWJR4 SPEG_HUMAN Decreases Expression [63]
Syntaxin-binding protein 2 (STXBP2) OTX8GUC4 STXB2_HUMAN Decreases Expression [63]
Histone-lysine N-methyltransferase EZH2 (EZH2) OTIEHTKW EZH2_HUMAN Decreases Expression [63]
Gamma-aminobutyric acid receptor subunit alpha-6 (GABRA6) OTX4UC3O GBRA6_HUMAN Decreases Expression [63]
snRNA-activating protein complex subunit 1 (SNAPC1) OTAPN1NI SNPC1_HUMAN Increases Expression [63]
Alpha-sarcoglycan (SGCA) OTCLJVZV SGCA_HUMAN Decreases Expression [63]
Cardiotrophin-1 (CTF1) OT6P9QBG CTF1_HUMAN Decreases Expression [63]
Hydroxyacylglutathione hydrolase, mitochondrial (HAGH) OTYMDAYV GLO2_HUMAN Decreases Expression [63]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) OTJDOL20 HCDH_HUMAN Decreases Expression [63]
Artemin (ARTN) OTWIWGL6 ARTN_HUMAN Decreases Expression [63]
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) OTXIGC6I LAIR1_HUMAN Increases Expression [63]
Psychosine receptor (GPR65) OTCF5O4G PSYR_HUMAN Increases Expression [63]
Ataxin-2-like protein (ATXN2L) OTP5M3R9 ATX2L_HUMAN Decreases Expression [63]
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1) OTGND2YZ SIA8A_HUMAN Increases Expression [63]
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) OTXGJ8N1 P55G_HUMAN Increases Expression [63]
Signal transducing adapter molecule 1 (STAM) OT6X5RR1 STAM1_HUMAN Decreases Expression [63]
Growth hormone secretagogue receptor type 1 (GHSR) OT1Y8ARK GHSR_HUMAN Decreases Expression [63]
Deoxyribonuclease-1-like 2 (DNASE1L2) OT56VFRL DNSL2_HUMAN Decreases Expression [63]
Forkhead box protein J1 (FOXJ1) OT7LLBZ7 FOXJ1_HUMAN Decreases Expression [63]
snRNA-activating protein complex subunit 3 (SNAPC3) OTSGZZCJ SNPC3_HUMAN Increases Expression [63]
Transcription factor IIIB 90 kDa subunit (BRF1) OTQC6DMG TF3B_HUMAN Decreases Expression [63]
Protein bicaudal D homolog 1 (BICD1) OT78IYPF BICD1_HUMAN Decreases Expression [63]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) OTHFFT6G SMRD1_HUMAN Increases Expression [63]
GTP-binding protein Rit2 (RIT2) OTSNYG0D RIT2_HUMAN Decreases Expression [63]
Cell cycle checkpoint control protein RAD9A (RAD9A) OTJ3AJQU RAD9A_HUMAN Decreases Expression [63]
Septin-5 (SEPTIN5) OT6JTJBO SEPT5_HUMAN Decreases Expression [63]
Probable proton-coupled zinc antiporter SLC30A3 (SLC30A3) OTEY876E ZNT3_HUMAN Decreases Expression [63]
Neuronal PAS domain-containing protein 1 (NPAS1) OTZKO6ZN NPAS1_HUMAN Decreases Expression [63]
Neurturin (NRTN) OT4PAKUY NRTN_HUMAN Decreases Expression [63]
Myeloid differentiation primary response protein MyD88 (MYD88) OTB4D6FL MYD88_HUMAN Decreases Expression [63]
Chorion-specific transcription factor GCMa (GCM1) OT5CPAUT GCM1_HUMAN Increases Expression [63]
Alpha-catulin (CTNNAL1) OTESJ6JD CTNL1_HUMAN Increases Expression [63]
Intercellular adhesion molecule 5 (ICAM5) OTDGGAFH ICAM5_HUMAN Decreases Expression [63]
Protocadherin gamma-C3 (PCDHGC3) OTDXTUMI PCDGK_HUMAN Decreases Expression [63]
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) OT1KKMYZ BAIP2_HUMAN Decreases Expression [63]
Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1) OTJCX8K9 MD1L1_HUMAN Decreases Expression [63]
NF-kappa-B essential modulator (IKBKG) OTNWJWSD NEMO_HUMAN Decreases Expression [63]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Decreases Activity [68]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Decreases Activity [68]
Suppressor of cytokine signaling 1 (SOCS1) OTWA9KFU SOCS1_HUMAN Decreases Expression [69]
Protein regulator of cytokinesis 1 (PRC1) OTHD0XS0 PRC1_HUMAN Decreases Expression [69]
Glutathione reductase, mitochondrial (GSR) OTM2TUYM GSHR_HUMAN Decreases Activity [70]
Platelet-derived growth factor subunit B (PDGFB) OTMFMFC3 PDGFB_HUMAN Increases Expression [71]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Expression [72]
Insulin-like growth factor I (IGF1) OTIIZR61 IGF1_HUMAN Decreases Expression [73]
Integrin beta-1 (ITGB1) OT6G1IAR ITB1_HUMAN Decreases Expression [73]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [74]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [75]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [76]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [72]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Cleavage [75]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Increases Expression [77]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [78]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [76]
Fanconi anemia group D2 protein (FANCD2) OTVEB5LF FACD2_HUMAN Increases Ubiquitination [79]
Three-prime repair exonuclease 1 (TREX1) OTQG7K12 TREX1_HUMAN Increases Expression [80]
Telomerase reverse transcriptase (TERT) OT085VVA TERT_HUMAN Decreases Response To Substance [81]
Eukaryotic initiation factor 4A-II (EIF4A2) OT08H03R IF4A2_HUMAN Affects Response To Substance [64]
Squalene monooxygenase (SQLE) OT0GGRDO ERG1_HUMAN Affects Response To Substance [64]
Sodium channel protein type 8 subunit alpha (SCN8A) OT0JGIZN SCN8A_HUMAN Affects Response To Substance [64]
Transmembrane protein 158 (TMEM158) OT0KUBBI TM158_HUMAN Affects Response To Substance [64]
Four and a half LIM domains protein 2 (FHL2) OT0OAYWT FHL2_HUMAN Affects Response To Substance [64]
Glutaminyl-peptide cyclotransferase (QPCT) OT0TSHP4 QPCT_HUMAN Affects Response To Substance [64]
DNA mismatch repair protein Msh2 (MSH2) OT10H1AB MSH2_HUMAN Affects Response To Substance [82]
Rho-related BTB domain-containing protein 3 (RHOBTB3) OT1BFKPH RHBT3_HUMAN Affects Response To Substance [64]
Retinaldehyde dehydrogenase 3 (ALDH1A3) OT1C9NKQ AL1A3_HUMAN Affects Response To Substance [64]
Nuclear factor 1 X-type (NFIX) OT1DPZAE NFIX_HUMAN Affects Response To Substance [64]
Granulocyte-macrophage colony-stimulating factor (CSF2) OT1M7D28 CSF2_HUMAN Affects Response To Substance [64]
Neurotrypsin (PRSS12) OT1MYL3L NETR_HUMAN Affects Response To Substance [64]
ATP-binding cassette sub-family G member 5 (ABCG5) OT1OMY93 ABCG5_HUMAN Affects Response To Substance [64]
Protein Lines homolog 1 (LINS1) OT1USO08 LINES_HUMAN Affects Response To Substance [64]
Protein ERGIC-53-like (LMAN1L) OT2CSBR3 LMA1L_HUMAN Affects Response To Substance [64]
Spermatogenesis-associated protein 12 (SPATA12) OT2EPI7P SPT12_HUMAN Affects Response To Substance [64]
Importin-4 (IPO4) OT2N5020 IPO4_HUMAN Affects Response To Substance [64]
Msx2-interacting protein (SPEN) OT37A2MD MINT_HUMAN Affects Response To Substance [64]
Protein-cysteine N-palmitoyltransferase HHAT (HHAT) OT3IXYII HHAT_HUMAN Affects Response To Substance [64]
Probable RNA-binding protein 19 (RBM19) OT3Q6UIM RBM19_HUMAN Affects Response To Substance [64]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Affects Response To Substance [64]
DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2) OT4DJFFU DNA2_HUMAN Affects Response To Substance [64]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Affects Response To Substance [64]
Microsomal glutathione S-transferase 2 (MGST2) OT4UGTDO MGST2_HUMAN Affects Response To Substance [64]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Affects Response To Substance [64]
DNA repair nuclease/redox regulator APEX1 (APEX1) OT53OI14 APEX1_HUMAN Increases Response To Substance [83]
ADP-ribosylation factor 1 (ARF1) OT5C4C3L ARF1_HUMAN Affects Response To Substance [64]
Leukocyte elastase inhibitor (SERPINB1) OT5RDUFO ILEU_HUMAN Affects Response To Substance [64]
Cytoplasmic phosphatidylinositol transfer protein 1 (PITPNC1) OT64TTGC PITC1_HUMAN Affects Response To Substance [64]
CCN family member 4 (CCN4) OT69BER9 CCN4_HUMAN Affects Response To Substance [64]
ETS translocation variant 1 (ETV1) OT6PMJIK ETV1_HUMAN Affects Response To Substance [64]
Transcription factor Dp-1 (TFDP1) OT6RZ7VT TFDP1_HUMAN Affects Response To Substance [64]
Melanophilin (MLPH) OT7ADCXL MELPH_HUMAN Affects Response To Substance [64]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Decreases Response To Substance [84]
Golgin subfamily A member 8B (GOLGA8B) OT807QHZ GOG8B_HUMAN Affects Response To Substance [64]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Affects Response To Substance [82]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Affects Response To Substance [64]
Glial cell line-derived neurotrophic factor (GDNF) OT8ICC4Z GDNF_HUMAN Decreases Response To Substance [85]
Paired mesoderm homeobox protein 2 (PRRX2) OT8UR4AU PRRX2_HUMAN Affects Response To Substance [64]
Thrombomodulin (THBD) OT8VHLKY TRBM_HUMAN Affects Response To Substance [64]
Serine/threonine-protein kinase LMTK2 (LMTK2) OT93MVIC LMTK2_HUMAN Affects Response To Substance [64]
Doublesex- and mab-3-related transcription factor C2 (DMRTC2) OT959L3E DMRTD_HUMAN Affects Response To Substance [64]
Metallothionein-1X (MT1X) OT9AKFVS MT1X_HUMAN Affects Response To Substance [64]
Secretory carrier-associated membrane protein 5 (SCAMP5) OT9MXA2J SCAM5_HUMAN Affects Response To Substance [64]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Affects Response To Substance [64]
N-acetylneuraminate lyase (NPL) OTA7P0TO NPL_HUMAN Affects Response To Substance [64]
Transgelin (TAGLN) OTAEZ0KP TAGL_HUMAN Affects Response To Substance [64]
DNA-3-methyladenine glycosylase (MPG) OTAHW80B 3MG_HUMAN Decreases Response To Substance [86]
Transcriptional and immune response regulator (TCIM) OTARUXQF TCIM_HUMAN Increases Response To Substance [64]
Cyclin-dependent kinase inhibitor 1C (CDKN1C) OTASTJ3Q CDN1C_HUMAN Affects Response To Substance [64]
Enteropeptidase (TMPRSS15) OTB277NN ENTK_HUMAN Affects Response To Substance [64]
Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1) OTBML9D9 CGAT1_HUMAN Affects Response To Substance [64]
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Decreases Response To Substance [87]
Bone morphogenetic protein 5 (BMP5) OTC0Y6E0 BMP5_HUMAN Affects Response To Substance [64]
Organic cation/carnitine transporter 2 (SLC22A5) OTC36TYB S22A5_HUMAN Affects Response To Substance [64]
Synaptopodin-2 (SYNPO2) OTC3U0YH SYNP2_HUMAN Affects Response To Substance [64]
3-mercaptopyruvate sulfurtransferase (MPST) OTCDPH5D THTM_HUMAN Affects Response To Substance [64]
Protein naked cuticle homolog 2 (NKD2) OTCYT3I6 NKD2_HUMAN Affects Response To Substance [64]
Cadherin-13 (CDH13) OTD2CYM5 CAD13_HUMAN Affects Response To Substance [64]
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) OTD5QPCI NT2NA_HUMAN Affects Response To Substance [64]
DNA polymerase subunit gamma-2 (POLG2) OTDBMZJB DPOG2_HUMAN Affects Response To Substance [64]
Stathmin (STMN1) OTDJ4RV0 STMN1_HUMAN Affects Response To Substance [88]
Solute carrier family 15 member 2 (SLC15A2) OTDV7YES S15A2_HUMAN Affects Response To Substance [64]
Maturin (MTURN) OTEBJNVG MTURN_HUMAN Affects Response To Substance [64]
Cysteine and glycine-rich protein 3 (CSRP3) OTECBJMV CSRP3_HUMAN Affects Response To Substance [64]
Testis development-related protein (TDRP) OTEFLMGF TDRP_HUMAN Affects Response To Substance [64]
C-X-C motif chemokine 2 (CXCL2) OTEJCYMY CXCL2_HUMAN Affects Response To Substance [64]
Glycine receptor subunit beta (GLRB) OTF37UG4 GLRB_HUMAN Affects Response To Substance [64]
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3GAL1) OTFCO8QX SIA4A_HUMAN Affects Response To Substance [64]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Increases Response To Substance [57]
Pleckstrin homology-like domain family A member 1 (PHLDA1) OTFTWMIQ PHLA1_HUMAN Affects Response To Substance [64]
Glutathione S-transferase Mu 2 (GSTM2) OTG4WT05 GSTM2_HUMAN Decreases Nitrosation [89]
DNA mismatch repair protein Mlh1 (MLH1) OTG5XDD8 MLH1_HUMAN Affects Response To Substance [82]
Polyhomeotic-like protein 2 (PHC2) OTG7ZO80 PHC2_HUMAN Affects Response To Substance [64]
Stanniocalcin-1 (STC1) OTGVVXYF STC1_HUMAN Affects Response To Substance [64]
COUP transcription factor 1 (NR2F1) OTGWZWYL COT1_HUMAN Affects Response To Substance [64]
Voltage-gated potassium channel subunit beta-2 (KCNAB2) OTH115IE KCAB2_HUMAN Affects Response To Substance [64]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Affects Uptake [90]
Urea transporter 1 (SLC14A1) OTH7UUV0 UT1_HUMAN Affects Response To Substance [64]
Ankyrin repeat domain-containing protein 1 (ANKRD1) OTHJ7JV9 ANKR1_HUMAN Affects Response To Substance [64]
Metallothionein-2 (MT2A) OTHOACHD MT2_HUMAN Affects Response To Substance [64]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Affects Response To Substance [64]
Phosphopentomutase (PGM2) OTIR1VDW PGM2_HUMAN Affects Response To Substance [64]
Differentially expressed in FDCP 6 homolog (DEF6) OTIRBYVK DEFI6_HUMAN Affects Response To Substance [64]
Insulin-like growth factor II (IGF2) OTJ4O6MW IGF2_HUMAN Affects Response To Substance [64]
N-glycosylase/DNA lyase (OGG1) OTJ97TF3 OGG1_HUMAN Decreases Response To Substance [91]
Protocadherin beta-2 (PCDHB2) OTJ9UCIH PCDB2_HUMAN Affects Response To Substance [64]
Alpha-(1,6)-fucosyltransferase (FUT8) OTJJCVG1 FUT8_HUMAN Affects Response To Substance [64]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Affects Response To Substance [64]
Tenascin (TNC) OTK4FSHR TENA_HUMAN Affects Response To Substance [64]
Endothelin-1 receptor (EDNRA) OTK9T5O3 EDNRA_HUMAN Affects Response To Substance [64]
Nuclear factor of activated T-cells 5 (NFAT5) OTKIE59S NFAT5_HUMAN Affects Response To Substance [64]
Nitric oxide synthase, inducible (NOS2) OTKKIOJ1 NOS2_HUMAN Decreases Response To Substance [92]
Adenomatous polyposis coli protein (APC) OTKV0TIK APC_HUMAN Affects Response To Substance [64]
Transmembrane protein 19 (TMEM19) OTKWMDYH TMM19_HUMAN Affects Response To Substance [64]
Pleckstrin homology domain-containing family G member 5 (PLEKHG5) OTL0S21W PKHG5_HUMAN Affects Response To Substance [64]
Glutathione S-transferase Mu 3 (GSTM3) OTLA2WJT GSTM3_HUMAN Decreases Nitrosation [89]
Splicing factor 1 (SF1) OTLEDM2S SF01_HUMAN Affects Response To Substance [64]
Glutathione S-transferase P (GSTP1) OTLP0A0Y GSTP1_HUMAN Decreases Response To Substance [93]
Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) OTLUM9L7 PK3C3_HUMAN Affects Response To Substance [64]
Probable ATP-dependent RNA helicase DHX37 (DHX37) OTM1A5KP DHX37_HUMAN Affects Response To Substance [64]
T-box transcription factor TBX3 (TBX3) OTM64N7K TBX3_HUMAN Affects Response To Substance [64]
Neuronal PAS domain-containing protein 2 (NPAS2) OTMRT2TS NPAS2_HUMAN Affects Response To Substance [64]
Exostosin-like 1 (EXTL1) OTMSNY9N EXTL1_HUMAN Affects Response To Substance [64]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Increases Response To Substance [94]
Popeye domain-containing protein 3 (POPDC3) OTN4FJ5J POPD3_HUMAN Affects Response To Substance [64]
Leukemia inhibitory factor (LIF) OTO46S5S LIF_HUMAN Increases Response To Substance [64]
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B) OTO7O3CU DYR1B_HUMAN Affects Response To Substance [64]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD) OTOMP6TH PK3CD_HUMAN Affects Response To Substance [64]
Anterior gradient protein 3 (AGR3) OTONJPDP AGR3_HUMAN Affects Response To Substance [64]
Histone-lysine N-methyltransferase MECOM (MECOM) OTP983W8 MECOM_HUMAN Affects Response To Substance [64]
Ras-related protein Rab-27B (RAB27B) OTPF9D0K RB27B_HUMAN Affects Response To Substance [64]
Plakophilin-3 (PKP3) OTPL1HRB PKP3_HUMAN Affects Response To Substance [64]
SPARC (SPARC) OTPN90H0 SPRC_HUMAN Affects Response To Substance [64]
Semaphorin-3A (SEMA3A) OTQJSV7W SEM3A_HUMAN Affects Response To Substance [64]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Affects Response To Substance [64]
Lipopolysaccharide-binding protein (LBP) OTQXAH4L LBP_HUMAN Affects Response To Substance [64]
Prolyl 3-hydroxylase 3 (P3H3) OTRC8QCM P3H3_HUMAN Affects Response To Substance [64]
Dickkopf-related protein 1 (DKK1) OTRDLUSP DKK1_HUMAN Increases Response To Substance [78]
Glutathione S-transferase theta-1 (GSTT1) OTRFMWBK GSTT1_HUMAN Decreases Nitrosation [89]
Chromodomain-helicase-DNA-binding protein 2 (CHD2) OTRKL6YC CHD2_HUMAN Affects Response To Substance [64]
Cell adhesion molecule 1 (CADM1) OTRWG9QS CADM1_HUMAN Affects Response To Substance [64]
Aldo-keto reductase family 1 member B1 (AKR1B1) OTRX72TH ALDR_HUMAN Affects Response To Substance [64]
Tumor protein D53 (TPD52L1) OTSA6U0I TPD53_HUMAN Affects Response To Substance [64]
Neutrophil gelatinase-associated lipocalin (LCN2) OTSB42BR NGAL_HUMAN Increases Response To Substance [95]
Glutathione S-transferase Mu 1 (GSTM1) OTSBF2MO GSTM1_HUMAN Decreases Response To Substance [96]
Short-chain dehydrogenase/reductase 3 (DHRS3) OTSK1DTP DHRS3_HUMAN Affects Response To Substance [64]
Inhibin beta A chain (INHBA) OTSP64PQ INHBA_HUMAN Affects Response To Substance [64]
Neuroblastoma suppressor of tumorigenicity 1 (NBL1) OTT37U4O NBL1_HUMAN Affects Response To Substance [64]
cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A) OTT8Q1AP PDE5A_HUMAN Affects Response To Substance [64]
Fanconi anemia group C protein (FANCC) OTTIDM3P FANCC_HUMAN Affects Response To Substance [64]
Keratin, type II cytoskeletal 8 (KRT8) OTTM4X11 K2C8_HUMAN Affects Response To Substance [64]
Interleukin-1 receptor type 1 (IL1R1) OTTU8959 IL1R1_HUMAN Affects Response To Substance [64]
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) OTTVT4MB TNR19_HUMAN Affects Response To Substance [64]
RAB6A-GEF complex partner protein 2 (RGP1) OTTZ63A6 RGP1_HUMAN Affects Response To Substance [64]
Protein Mdm4 (MDM4) OTU10BSF MDM4_HUMAN Decreases Response To Substance [97]
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) OTU1KZPV AAPK2_HUMAN Affects Response To Substance [64]
Transcription factor AP-2 gamma (TFAP2C) OTUDIW05 AP2C_HUMAN Affects Response To Substance [64]
F-box only protein 32 (FBXO32) OTUE978R FBX32_HUMAN Affects Response To Substance [64]
Syntaxin-binding protein 6 (STXBP6) OTUEKTIP STXB6_HUMAN Affects Response To Substance [64]
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Affects Response To Substance [64]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Affects Response To Substance [64]
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (PREX1) OTUTPVA9 PREX1_HUMAN Affects Response To Substance [64]
Forkhead box protein F2 (FOXF2) OTV20NGX FOXF2_HUMAN Affects Response To Substance [64]
Transcription factor SOX-9 (SOX9) OTVDJFGN SOX9_HUMAN Affects Response To Substance [64]
Arrestin domain-containing protein 2 (ARRDC2) OTVEOXAG ARRD2_HUMAN Affects Response To Substance [64]
Ninein (NIN) OTVH3M4Z NIN_HUMAN Affects Response To Substance [64]
Polypeptide N-acetylgalactosaminyltransferase 15 (GALNT15) OTVK9EHD GLT15_HUMAN Affects Response To Substance [64]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) OTVLI4DD TNAP3_HUMAN Increases Response To Substance [64]
Ankyrin-2 (ANK2) OTWB4R1Y ANK2_HUMAN Affects Response To Substance [64]
Integrin beta-3 (ITGB3) OTWCK1K6 ITB3_HUMAN Increases Response To Substance [98]
Syndecan-1 (SDC1) OTWKRVZC SDC1_HUMAN Affects Response To Substance [64]
Mannan-binding lectin serine protease 1 (MASP1) OTWWCNZP MASP1_HUMAN Affects Response To Substance [64]
Nuclear factor 1 B-type (NFIB) OTX94PD0 NFIB_HUMAN Affects Response To Substance [64]
E3 ubiquitin-protein ligase TRIM50 (TRIM50) OTXA2IXF TRI50_HUMAN Affects Response To Substance [64]
Sphingosine 1-phosphate receptor 3 (S1PR3) OTXBIYO8 S1PR3_HUMAN Affects Response To Substance [64]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) OTXOQDSG IFIT1_HUMAN Affects Response To Substance [64]
Engulfment and cell motility protein 1 (ELMO1) OTY2ORXK ELMO1_HUMAN Affects Response To Substance [64]
Regulator of cell cycle RGCC (RGCC) OTYJMLWM RGCC_HUMAN Affects Response To Substance [64]
GTPase-activating Rap/Ran-GAP domain-like protein 3 (GARNL3) OTYK950M GARL3_HUMAN Affects Response To Substance [64]
Chloride intracellular channel protein 1 (CLIC1) OTYLFWNG CLIC1_HUMAN Decreases Response To Substance [99]
Tissue factor pathway inhibitor 2 (TFPI2) OTZCRWOR TFPI2_HUMAN Affects Response To Substance [64]
AP-1 complex subunit sigma-2 (AP1S2) OTZHJFYI AP1S2_HUMAN Affects Response To Substance [64]
Metallothionein-1F (MT1F) OTZVUYG1 MT1F_HUMAN Affects Response To Substance [64]
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References

1 ClinicalTrials.gov (NCT00027612) Irinotecan Plus Radiation Therapy Followed By Chemotherapy in Treating Patients With Glioblastoma Multiforme
2 Irinotecan FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6823).
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6800).
5 Levels and distribution of BCNU in GBM tumors following intratumoral injection of DTI-015 (BCNU-ethanol). Neuro Oncol. 2007 Jan;9(1):12-9.
6 Carmustine-induced toxicity, DNA crosslinking and O6-methylguanine-DNA methyltransferase activity in two human lung cancer cell lines. Eur J Cancer. 1991;27(12):1658-62.
7 Stereotactic injection of DTI-015 into recurrent malignant gliomas: phase I/II trial. Neoplasia. 2003 Jan-Feb;5(1):9-16.
8 A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
9 Characterization of the UDP glucuronosyltransferase activity of human liver microsomes genotyped for the UGT1A1*28 polymorphism. Drug Metab Dispos. 2007 Dec;35(12):2270-80.
10 Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene. Mol Pharmacol. 2005 May;67(5):1732-9.
11 In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
12 Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
13 Combination of oxaliplatin and irinotecan on human colon cancer cell lines: activity in vitro and in vivo. Anticancer Drugs. 2001 Oct;12(9):741-51. doi: 10.1097/00001813-200110000-00006.
14 Gene expression profile of colon cancer cell lines treated with SN-38. Chemotherapy. 2010;56(1):17-25. doi: 10.1159/000287353. Epub 2010 Feb 24.
15 UGT1A10 is responsible for SN-38 glucuronidation and its expression in human lung cancers. Anticancer Res. 2004 Sep-Oct;24(5A):2893-6.
16 Differential rates of glucuronidation for 7-ethyl-10-hydroxy-camptothecin (SN-38) lactone and carboxylate in human and rat microsomes and recombinant UDP-glucuronosyltransferase isoforms. Drug Metab Dispos. 2005 Jul;33(7):977-83. doi: 10.1124/dmd.104.003491. Epub 2005 Apr 15.
17 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
18 ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P. Mol Pharmacol. 1999 May;55(5):921-8.
19 Intestinal transport of irinotecan in Caco-2 cells and MDCK II cells overexpressing efflux transporters Pgp, cMOAT, and MRP1. Drug Metab Dispos. 2002 Jul;30(7):763-70.
20 Cyclosporin A, tacrolimus and sirolimus are potent inhibitors of the human breast cancer resistance protein (ABCG2) and reverse resistance to mitoxantrone and topotecan. Cancer Chemother Pharmacol. 2006 Sep;58(3):374-83.
21 P-glycoprotein, but not multidrug resistance protein 4, plays a role in the systemic clearance of irinotecan and SN-38 in mice. Drug Metab Lett. 2010 Dec;4(4):195-201.
22 Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy. Curr Cancer Drug Targets. 2008 Aug;8(5):414-20.
23 Irinotecan and its active metabolite, SN-38: review of bioanalytical methods and recent update from clinical pharmacology perspectives. Biomed Chromatogr. 2010 Jan;24(1):104-23.
24 Pharmacogenetics of irinotecan metabolism and transport: an update. Toxicol In Vitro. 2006 Mar;20(2):163-75.
25 Drug Interactions Flockhart Table
26 Drugs that may have potential CYP2B6 interactions.
27 Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. Drug Metab Dispos. 2004 May;32(5):505-11.
28 Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats. Cancer Res. 1996 Aug 15;56(16):3752-7.
29 Transcriptional activation of the carboxylesterase 2 gene by the p53 pathway. Cancer Biol Ther. 2006 Nov;5(11):1450-6.
30 Concise prediction models of anticancer efficacy of 8 drugs using expression data from 12 selected genes. Int J Cancer. 2004 Sep 10;111(4):617-26. doi: 10.1002/ijc.20289.
31 A mechanistic study on reduced toxicity of irinotecan by coadministered thalidomide, a tumor necrosis factor-alpha inhibitor. J Pharmacol Exp Ther. 2006 Oct;319(1):82-104. doi: 10.1124/jpet.106.103606. Epub 2006 Jun 30.
32 Severe toxicities after irinotecan-based chemotherapy in a patient with lung cancer: a homozygote for the SLCO1B1*15 allele. Ther Drug Monit. 2007 Oct;29(5):666-8. doi: 10.1097/FTD.0b013e3181357364.
33 Interaction of irinotecan (CPT-11) and its active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38) with human cytochrome P450 enzymes. Drug Metab Dispos. 2002 Apr;30(4):391-6.
34 5-Fluorouracil: identification of novel downstream mediators of tumour response. Anticancer Res. 2004 Mar-Apr;24(2A):417-23.
35 Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing. J Med Chem. 2011 Dec 22;54(24):8328-42. doi: 10.1021/jm2007326. Epub 2011 Nov 23.
36 Chemotherapy and TRAIL-mediated colon cancer cell death: the roles of p53, TRAIL receptors, and c-FLIP. Mol Cancer Ther. 2005 Dec;4(12):2026-36. doi: 10.1158/1535-7163.MCT-05-0262.
37 The PPAR-dependent effect of flavonoid luteolin against damage induced by the chemotherapeutic irinotecan in human intestinal cells. Chem Biol Interact. 2022 Jan 5;351:109712. doi: 10.1016/j.cbi.2021.109712. Epub 2021 Oct 23.
38 Irinotecan induces senescence and apoptosis in colonic cells in vitro. Toxicol Lett. 2012 Oct 2;214(1):1-8. doi: 10.1016/j.toxlet.2012.08.004. Epub 2012 Aug 14.
39 Ursolic and oleanolic acids in combination therapy inhibit migration of colon cancer cells through down-regulation of the uPA/uPAR-dependent MMPs pathway. Chem Biol Interact. 2022 Dec 1;368:110202. doi: 10.1016/j.cbi.2022.110202. Epub 2022 Oct 1.
40 Gefitinib ("Iressa", ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells. Cancer Chemother Pharmacol. 2005 Apr;55(4):393-403. doi: 10.1007/s00280-004-0904-0. Epub 2004 Oct 5.
41 Pharmacological targeting of NF-kappaB potentiates the effect of the topoisomerase inhibitor CPT-11 on colon cancer cells. Br J Cancer. 2008 Jan 29;98(2):335-44. doi: 10.1038/sj.bjc.6604082. Epub 2008 Jan 8.
42 The expressions of p21 and pRB may be good indicators for the sensitivity of esophageal squamous cell cancers to CPT-11: Cell proliferation activity correlates with the effect of CPT-11. Cancer Sci. 2004 May;95(5):464-8. doi: 10.1111/j.1349-7006.2004.tb03233.x.
43 Sensitization of colorectal cancer to irinotecan therapy by PARP inhibitor rucaparib. Invest New Drugs. 2019 Oct;37(5):948-960. doi: 10.1007/s10637-018-00717-9. Epub 2019 Jan 5.
44 Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N'-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells. Mol Pharmacol. 2008 Aug;74(2):517-26. doi: 10.1124/mol.107.043620. Epub 2008 May 20.
45 Effect of p53 status and STAT1 on chemotherapy-induced, Fas-mediated apoptosis in colorectal cancer. Cancer Res. 2005 Oct 1;65(19):8951-60. doi: 10.1158/0008-5472.CAN-05-0961.
46 Decreased translation of p21waf1 mRNA causes attenuated p53 signaling in some p53 wild-type tumors. Cell Cycle. 2012 May 1;11(9):1818-26. doi: 10.4161/cc.20208. Epub 2012 May 1.
47 Exogenous expression of hRFI induces multidrug resistance through escape from apoptosis in colorectal cancer cells. Anticancer Res. 2005 Jul-Aug;25(4):2737-41.
48 Enhancement of DNA topoisomerase I inhibitor-induced apoptosis by ursodeoxycholic acid. Mol Cancer Ther. 2006 Jan;5(1):68-79. doi: 10.1158/1535-7163.MCT-05-0107.
49 The histone-deacetylase inhibitor SAHA potentiates proapoptotic effects of 5-fluorouracil and irinotecan in hepatoma cells. J Cancer Res Clin Oncol. 2005 Jun;131(6):385-94. doi: 10.1007/s00432-004-0664-6. Epub 2005 Mar 8.
50 DNA topoisomerase inhibitor, etoposide, enhances GC-box-dependent promoter activity via Sp1 phosphorylation. Cancer Sci. 2007 Jun;98(6):858-63. doi: 10.1111/j.1349-7006.2007.00476.x. Epub 2007 Apr 18.
51 Irinotecan and DNA-PKcs inhibitors synergize in killing of colon cancer cells. Invest New Drugs. 2012 Jun;30(3):1248-56. doi: 10.1007/s10637-010-9626-9. Epub 2011 Jan 11.
52 gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. Cancer Res. 2009 Jan 15;69(2):573-82. doi: 10.1158/0008-5472.CAN-08-2088.
53 Gene expression analysis using human cancer xenografts to identify novel predictive marker genes for the efficacy of 5-fluorouracil-based drugs. Cancer Sci. 2006 Jun;97(6):510-22. doi: 10.1111/j.1349-7006.2006.00204.x.
54 Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cells. Mol Cancer. 2011 Apr 20;10:44. doi: 10.1186/1476-4598-10-44.
55 Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer. Oncol Rep. 2008 Nov;20(5):999-1004.
56 A genome-wide association study for irinotecan-related severe toxicities in patients with advanced non-small-cell lung cancer. Pharmacogenomics J. 2013 Oct;13(5):417-22. doi: 10.1038/tpj.2012.24. Epub 2012 Jun 5.
57 Potentiation of chemotherapeutic agents following antagonism of nuclear factor kappa B in human gliomas. J Neurooncol. 2003 Feb;61(3):187-96. doi: 10.1023/a:1022554824129.
58 Copper-transporting P-type ATPase, ATP7A, confers multidrug resistance and its expression is related to resistance to SN-38 in clinical colon cancer. Cancer Res. 2007 May 15;67(10):4860-8. doi: 10.1158/0008-5472.CAN-06-3096.
59 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Cancer Sci. 2013 Aug;104(8):1074-82. doi: 10.1111/cas.12186. Epub 2013 Jun 10.
60 Expression of ABCB6 is related to resistance to 5-FU, SN-38 and vincristine. Anticancer Res. 2014 Sep;34(9):4767-73.
61 Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2. Mol Pharmacol. 2007 Sep;72(3):686-94. doi: 10.1124/mol.107.036889. Epub 2007 May 30.
62 Drg1 expression in 131 colorectal liver metastases: correlation with clinical variables and patient outcomes. Clin Cancer Res. 2005 May 1;11(9):3296-302. doi: 10.1158/1078-0432.CCR-04-2417.
63 Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
64 Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006 Jan 10;24(2):274-87. doi: 10.1200/JCO.2005.02.9405. Epub 2005 Dec 19.
65 Wilms' tumor 1 silencing decreases the viability and chemoresistance of glioblastoma cells in vitro: a potential role for IGF-1R de-repression. J Neurooncol. 2011 May;103(1):87-102. doi: 10.1007/s11060-010-0374-7. Epub 2010 Sep 4.
66 Principal drug-metabolizing enzyme systems in L1210 leukemia sensitive or resistant to BCNU in vivo. Leuk Res. 1994 Nov;18(11):829-35.
67 Expression of glutathione S-transferase T1 (GSTT1) in human brain tumours. Histol Histopathol. 2006 Nov;21(11):1199-207.
68 Proline analogue of nitrosourea as a new cytotoxic prodrug. Arch Pharm (Weinheim). 2009 Nov;342(11):632-9.
69 Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling. Mutat Res. 2007 Jun 1;619(1-2):16-29. doi: 10.1016/j.mrfmmm.2006.12.007. Epub 2007 Feb 8.
70 Decreased GSSG reductase activity enhances cellular zinc toxicity in three human lung cell lines. Arch Toxicol. 2003 Mar;77(3):131-7. doi: 10.1007/s00204-002-0421-z. Epub 2003 Jan 4.
71 Fatal pulmonary fibrosis associated with BCNU: the relative role of platelet-derived growth factor-B, insulin-like growth factor I, transforming growth factor-beta1 and cyclooxygenase-2. Bone Marrow Transplant. 2004 Oct;34(7):609-14. doi: 10.1038/sj.bmt.1704616.
72 Inactivated MGMT by O6-benzylguanine is associated with prolonged G2/M arrest in cancer cells treated with BCNU. Oncogene. 2005 Mar 24;24(13):2175-83. doi: 10.1038/sj.onc.1208250.
73 Proline-linked nitrosoureas as prolidase-convertible prodrugs in human breast cancer cells. Pharmacol Rep. 2008 Mar-Apr;60(2):171-82.
74 Enhanced in vitro invasiveness and drug resistance with altered gene expression patterns in a human lung carcinoma cell line after pulse selection with anticancer drugs. Int J Cancer. 2004 Sep 10;111(4):484-93. doi: 10.1002/ijc.20230.
75 Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage. Carcinogenesis. 2014 Mar;35(3):692-702. doi: 10.1093/carcin/bgt366. Epub 2013 Nov 5.
76 BCNU down-regulates anti-apoptotic proteins bcl-xL and Bcl-2 in association with cell death in oligodendroglioma-derived cells. J Neurooncol. 2004 Jul;68(3):233-41. doi: 10.1023/b:neon.0000033382.40601.5a.
77 Noninvasive assessment of E2F-1-mediated transcriptional regulation in vivo. Cancer Res. 2008 Jul 15;68(14):5932-40. doi: 10.1158/0008-5472.CAN-07-6373.
78 Elevated expression of Dickkopf-1 increases the sensitivity of human glioma cell line SHG44 to BCNU. J Exp Clin Cancer Res. 2010 Oct 4;29(1):131. doi: 10.1186/1756-9966-29-131.
79 The Fanconi anemia (FA) pathway confers glioma resistance to DNA alkylating agents. J Mol Med (Berl). 2007 May;85(5):497-509. doi: 10.1007/s00109-006-0153-2. Epub 2007 Jan 13.
80 Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs. Biochim Biophys Acta. 2013 Aug;1833(8):1832-43. doi: 10.1016/j.bbamcr.2013.03.029. Epub 2013 Apr 8.
81 Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor. Mol Pharmacol. 2003 Jan;63(1):192-202. doi: 10.1124/mol.63.1.192.
82 Carmustine-resistant cancer cells are sensitized to temozolomide as a result of enhanced mismatch repair during the development of carmustine resistance. Mol Pharmacol. 2008 Jul;74(1):82-91. doi: 10.1124/mol.107.041988. Epub 2008 Apr 22.
83 A dominant-negative form of the major human abasic endonuclease enhances cellular sensitivity to laboratory and clinical DNA-damaging agents. Mol Cancer Res. 2007 Jan;5(1):61-70. doi: 10.1158/1541-7786.MCR-06-0329.
84 Adenovirus-mediated transfer of siRNA against basic fibroblast growth factor mRNA enhances the sensitivity of glioblastoma cells to chemotherapy. Med Oncol. 2011 Mar;28(1):24-30. doi: 10.1007/s12032-010-9445-z. Epub 2010 Feb 24.
85 Glial cell-line derived neurotrophic factor (GDNF) family of ligands confer chemoresistance in a ligand-specific fashion in malignant gliomas. J Clin Neurosci. 2009 Mar;16(3):427-36. doi: 10.1016/j.jocn.2008.06.002. Epub 2009 Jan 12.
86 Sensitization of human carcinoma cells to alkylating agents by small interfering RNA suppression of 3-alkyladenine-DNA glycosylase. Cancer Res. 2005 Nov 15;65(22):10472-7. doi: 10.1158/0008-5472.CAN-05-1495.
87 Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases. Cancer Res. 2000 Oct 1;60(19):5464-9.
88 The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. J Natl Cancer Inst. 2007 Apr 18;99(8):639-52. doi: 10.1093/jnci/djk135.
89 The polymorphic human glutathione transferase T1-1, the most efficient glutathione transferase in the denitrosation and inactivation of the anticancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea. Biochem Pharmacol. 2002 Jan 15;63(2):191-7. doi: 10.1016/s0006-2952(01)00846-2.
90 Association of carmustine with a lipid emulsion: in vitro, in vivo and preliminary studies in cancer patients. Cancer Chemother Pharmacol. 2002 Jun;49(6):487-98. doi: 10.1007/s00280-002-0437-3. Epub 2002 Mar 21.
91 Protection of mammalian cells against chemotherapeutic agents thiotepa, 1,3-N,N'-bis(2-chloroethyl)-N-nitrosourea, and mafosfamide using the DNA base excision repair genes Fpg and alpha-hOgg1: implications for protective gene therapy applications. J Pharmacol Exp Ther. 2001 Mar;296(3):825-31.
92 Nitric oxide and BCNU chemoresistance in C6 glioma cells: role of S-nitrosoglutathione. Free Radic Biol Med. 2004 May 15;36(10):1317-28. doi: 10.1016/j.freeradbiomed.2004.02.010.
93 In vitro drug response and molecular markers associated with drug resistance in malignant gliomas. Clin Cancer Res. 2006 Aug 1;12(15):4523-32. doi: 10.1158/1078-0432.CCR-05-1830.
94 Role of p16 and p14ARF in radio- and chemosensitivity of malignant gliomas. Oncol Rep. 2006 Jul;16(1):127-32.
95 Down-regulation of lipocalin 2 contributes to chemoresistance in glioblastoma cells. J Neurochem. 2009 Dec;111(5):1238-51. doi: 10.1111/j.1471-4159.2009.06410.x. Epub 2009 Oct 5.
96 Glutathione S-transferase M1 inhibits dexamethasone-induced apoptosis in association with the suppression of Bim through dual mechanisms in a lymphoblastic leukemia cell line. Cancer Sci. 2010 Mar;101(3):767-73. doi: 10.1111/j.1349-7006.2009.01432.x. Epub 2010 Jan 7.
97 HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea. Neuro Oncol. 2010 Sep;12(9):956-66. doi: 10.1093/neuonc/noq045. Epub 2010 May 14.
98 Pro-apoptotic role of integrin 3 in glioma cells. J Neurochem. 2011 May;117(3):494-503. doi: 10.1111/j.1471-4159.2011.07219.x. Epub 2011 Mar 15.
99 Pharmacologic blockade of chloride channel synergistically enhances apoptosis of chemotherapeutic drug-resistant cancer stem cells. Biochem Biophys Res Commun. 2008 Sep 5;373(4):539-44. doi: 10.1016/j.bbrc.2008.06.070. Epub 2008 Jun 30.