Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCPF90)

• Drug Name: Mivebresib Drug Info
• Synonyms: ABBV-075; 1445993-26-9; UNII-VR86R11J7J; VR86R11J7J; N-[4-(2,4-Difluorophenoxy)-3-(6-Methyl-7-Oxo-6,7-Dihydro-1h-Pyrrolo[2,3-C]pyridin-4-Yl)phenyl]ethanesulfonamide; N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide; 8NG; Mivebresib [INN]; ABBV-075 (Mivebresib); ABBV075; GTPL9117; SCHEMBL15068241; CHEMBL3987016; Mivebresib(ABBV-075 pound(c); MolPort-044-561-801; RDONXGFGWSSFMY-UHFFFAOYSA-N; BDBM220447; EX-A1082; s8400; ZINC146486516; AKOS030628486; CS-5815

Indication

Disease Entry	ICD 11	Status	REF
Acute myeloid leukaemia	2A60	Phase 1	[1]
Multiple myeloma	2A83	Phase 1	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

• Cross-matching ID:
  PubChem CID: 71600087
  CAS Number: CAS 1445993-26-9
  TTD Drug ID: DMCPF90

Molecule-Related Drug Atlas

Drug(s) Targeting Bromodomain and extraterminal domain protein (BET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CPI-0610	DMPXOYJ	Myelofibrosis	2A20.2	Phase 3	[1]
ZEN-3694	DM6VQTF	Prostate cancer	2C82.0	Phase 2	[3]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[1]
BMS-986158	DM6LDI4	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]
INCB054329	DM7TZL0	Refractory hematologic malignancy	2A85.5	Phase 1/2	[4]
INCB057643	DMG65CV	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[5]
ODM-207	DMOKVJD	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[6]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[7]
GSK525762	DMPAWBN	Haematological malignancy	2B33.Y	Phase 1	[1]
PLX51107	DMXLHVW	Haematological malignancy	2B33.Y	Phase 1	[1]

Drug(s) Affected By Coiled-coil domain-containing protein 154 (CCDC154)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[10]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[13]

Drug(s) Affected By Nuclear pore complex-interacting protein family member A5 (NPIPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[2]

Drug(s) Affected By Sodium-dependent phosphate transport protein 3 (SLC17A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[15]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[20]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]

Drug(s) Affected By AT-rich interactive domain-containing protein 1A (ARID1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Indomethacin	DMSC4A7	Bursitis		Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[20]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[25]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[26]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[21]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[21]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[29]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[30]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[36]

Drug(s) Affected By FYN-binding protein 1 (FYB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]

Drug(s) Affected By Forkhead box protein P2 (FOXP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[47]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[49]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[50]
Crocin	DM5F24X	N. A.	N. A.	Phase 3	[51]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]

Drug(s) Affected By Calpain-5 (CAPN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[54]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[55]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[58]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[59]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[10]

Drug(s) Affected By RNA-binding protein Musashi homolog 1 (MSI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[61]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[44]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[63]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[65]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[67]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[68]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[70]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]

Drug(s) Affected By Uncharacterized protein KIAA0513 (KIAA0513)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]

Drug(s) Affected By Tetraspanin-1 (TSPAN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[79]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[80]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[81]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[82]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]

Drug(s) Affected By Bromodomain-containing protein 4 (BRD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[84]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[84]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[47]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (PLCH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[87]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[88]

Drug(s) Affected By Breast carcinoma-amplified sequence 1 (BCAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[90]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[82]

Drug(s) Affected By Integrin alpha-10 (ITGA10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[91]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[92]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[93]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[94]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[2]

Drug(s) Affected By Cytochrome P450 7B1 (CYP7B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[60]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[97]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[98]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[99]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[97]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]

Drug(s) Affected By Slit homolog 2 protein (SLIT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Selenium	DM25CGV	N. A.	N. A.	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[47]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[103]

Drug(s) Affected By Protein HEXIM1 (HEXIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[104]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[105]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[20]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]

Drug(s) Affected By Apolipoprotein L3 (APOL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[20]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[107]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[101]

Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[108]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[111]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[112]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Haloperidol	DM96SE0	Delirium		Approved	[114]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[115]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[116]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[118]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[119]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[124]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[125]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[126]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[125]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[130]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[132]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[126]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[127]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Selenium	DM25CGV	N. A.	N. A.	Approved	[134]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[135]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[65]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[136]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]

Drug(s) Affected By Erythropoietin (EPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[137]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[140]
Fenoterol	DMIP3ZV	Asthma	CA23	Approved	[141]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[142]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[143]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[144]

Drug(s) Affected By N-myc proto-oncogene protein (MYCN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[147]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[148]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[149]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[151]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[152]

Drug(s) Affected By Heat shock protein beta-1 (HSPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Selenium	DM25CGV	N. A.	N. A.	Approved	[101]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]

Drug(s) Affected By Inhibin alpha chain (INHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[160]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[161]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[162]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[2]

Drug(s) Affected By Galectin-2 (LGALS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Bortezomib	DMNO38U	Leukemia		Approved	[164]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[90]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[94]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[165]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[166]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Selenium	DM25CGV	N. A.	N. A.	Approved	[134]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[167]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[168]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[169]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[171]

Drug(s) Affected By Eukaryotic translation initiation factor 4E (EIF4E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[176]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[178]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[177]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]

Drug(s) Affected By Complement component C8 alpha chain (C8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[56]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[96]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[179]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[180]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[182]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[183]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[184]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[183]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[185]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[186]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[187]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[188]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[191]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[114]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[179]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[192]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[193]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[195]

Drug(s) Affected By Glucose-6-phosphate 1-dehydrogenase (G6PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[114]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[196]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[198]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[174]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[201]

Drug(s) Affected By Plastin-2 (LCP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[202]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[203]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[165]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[116]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Selenium	DM25CGV	N. A.	N. A.	Approved	[134]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[167]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[184]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[204]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[84]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]

Drug(s) Affected By Leukemia inhibitory factor (LIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[169]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[207]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Selenium	DM25CGV	N. A.	N. A.	Approved	[101]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[210]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[211]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[212]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[213]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[214]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[216]

Drug(s) Affected By Tyrosine aminotransferase (TAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[217]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[219]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[220]
Miconazole	DMPMYE8	Cutaneous candidiasis	1F23.14	Approved	[221]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[222]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]

Drug(s) Affected By Endoglin (ENG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[225]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Ximelegatran	DMU8ANS	Myocardial infarction	BA41-BA43	Approved	[226]

Drug(s) Affected By Interleukin-1 receptor antagonist protein (IL1RN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[227]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[227]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[229]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[230]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]

Drug(s) Affected By Glutathione hydrolase 1 proenzyme (GGT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[42]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[231]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[232]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[114]

Drug(s) Affected By Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[96]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[233]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]

Drug(s) Affected By Alanine--glyoxylate aminotransferase (AGXT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[234]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[18]

Drug(s) Affected By Glycerol-3-phosphate dehydrogenase , cytoplasmic (GPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[235]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[103]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[20]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[2]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[236]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[237]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[238]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[239]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[65]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[240]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[242]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[243]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[244]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[245]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[195]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[246]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[247]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[248]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Selenium	DM25CGV	N. A.	N. A.	Approved	[101]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[135]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[250]

Drug(s) Affected By Protein kinase C eta type (PRKCH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Indomethacin	DMSC4A7	Bursitis		Approved	[252]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[69]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[94]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[253]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[254]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[255]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[256]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[257]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[258]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[259]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[260]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[261]

Drug(s) Affected By Proteasome subunit beta type-8 (PSMB8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[264]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Sibutramine	DMFJTDI	Obesity	5B81	Approved	[265]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[266]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[254]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[267]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[268]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[269]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[253]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[114]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[256]

Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[169]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[271]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[272]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]

Drug(s) Affected By cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[47]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[103]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[273]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[274]

Drug(s) Affected By Alpha-L-iduronidase (IDUA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[275]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[101]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[2]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[276]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[124]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[116]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[277]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[248]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[167]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[278]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[184]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[279]

Drug(s) Affected By Proteasome subunit beta type-10 (PSMB10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[101]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[280]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[281]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]

Drug(s) Affected By Signal transducer and activator of transcription 5A (STAT5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[282]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[283]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[284]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[285]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[286]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[89]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[287]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[288]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[289]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[290]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[237]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[238]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[291]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[135]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[292]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[293]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[295]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[296]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[298]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[299]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[300]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[301]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[303]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[304]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[305]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[278]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[307]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[308]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[309]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[310]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[311]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[312]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[313]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[247]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[278]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[314]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[315]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[316]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[317]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[318]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[319]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]

Drug(s) Affected By Sodium- and chloride-dependent glycine transporter 1 (SLC6A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[321]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[322]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[323]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[324]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[324]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[324]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[324]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[324]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[324]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[324]

Drug(s) Affected By Aldo-keto reductase family 1 member D1 (AKR1D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[235]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[325]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[18]

Drug(s) Affected By 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 (FUT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[326]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[327]

Drug(s) Affected By Ephrin-B2 (EFNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[328]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[89]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[329]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[20]

Drug(s) Affected By Serine/threonine-protein kinase PLK1 (PLK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[330]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[75]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]

Drug(s) Affected By Huntingtin-associated protein 1 (HAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[90]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[93]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[331]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[332]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[333]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[334]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[334]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[169]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[335]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[336]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[215]

Drug(s) Affected By Protein ripply3 (RIPPLY3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[337]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[337]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[337]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[338]

Drug(s) Affected By T-box transcription factor TBX4 (TBX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[104]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[2]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[63]

Drug(s) Affected By Transmembrane protease serine 3 (TMPRSS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[339]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[340]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[82]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[341]

Drug(s) Affected By Claudin-2 (CLDN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[342]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[343]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[345]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[346]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[20]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[347]

Drug(s) Affected By Sestrin-3 (SESN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[348]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[349]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[350]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Inhibin beta E chain (INHBE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[351]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[352]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[351]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[351]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[351]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[56]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[353]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[351]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[354]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[356]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[357]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[358]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[359]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[348]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[360]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[242]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[361]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[362]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[363]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[364]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[365]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]

Drug(s) Affected By Microtubule-associated protein 1A (MAP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Haloperidol	DM96SE0	Delirium		Approved	[196]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[196]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[366]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[367]

Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[368]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[369]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[370]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[371]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[348]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[30]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[372]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]

Drug(s) Affected By Perilipin-5 (PLIN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[20]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[90]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[94]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[82]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[188]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[305]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[179]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[192]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[115]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[373]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[248]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[374]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[184]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[375]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[182]
Selenium	DM25CGV	N. A.	N. A.	Approved	[101]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[376]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[169]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[377]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[378]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[30]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[379]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[115]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[380]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[381]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[382]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[383]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[384]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[385]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[386]

Drug(s) Affected By Forkhead box protein M1 (FOXM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[166]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[387]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[388]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[389]

Drug(s) Affected By Schlafen family member 5 (SLFN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[387]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[390]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[104]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[391]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[20]

Drug(s) Affected By Putative sodium-coupled neutral amino acid transporter 11 (SLC38A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[325]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[104]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[18]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]

Drug(s) Affected By Protein mab-21-like 4 (MAB21L4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[90]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[392]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[82]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[393]

Drug(s) Affected By Serine/threonine-protein kinase PAK 1 (PAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[394]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[367]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[395]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[387]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[396]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[104]

Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[397]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[135]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[307]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[398]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[349]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[363]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]

Drug(s) Affected By GRB2-related adapter protein (GRAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[90]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[82]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[326]

Drug(s) Affected By Potassium voltage-gated channel subfamily C member 3 (KCNC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[96]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[82]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]

Drug(s) Affected By Dihydropyrimidinase-related protein 3 (DPYSL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[399]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[348]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[361]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[324]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[324]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]

Drug(s) Affected By Lymphocyte antigen 6D (LY6D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[400]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[90]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]

Drug(s) Affected By cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[75]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[401]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[79]
Roflumilast	DMPGHY8	Asthma	CA23	Approved	[402]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]

Drug(s) Affected By Alpha-internexin (INA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[392]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[49]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[403]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[94]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[404]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[405]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[406]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[169]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[407]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[408]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[409]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[410]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[411]

Drug(s) Affected By Transcription factor NF-E2 45 kDa subunit (NFE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[412]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Aclarubicin	DMLFZHD	Acute myeloid leukaemia	2A60	Approved	[413]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[338]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[338]
Pomalidomide	DMTGBAX	Plasma cell myeloma	2A83.1	Approved	[414]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[415]

Drug(s) Affected By POU domain class 2-associating factor 1 (POU2AF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[416]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[417]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[418]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]

Drug(s) Affected By Protein Aster-B (GRAMD1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[90]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[419]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[404]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[420]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[21]

Drug(s) Affected By Protein phosphatase 1J (PPM1J)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[101]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[79]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[392]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[50]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[94]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[69]

Drug(s) Affected By Uncharacterized protein C9orf152 (C9ORF152)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[10]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[203]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[341]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[396]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[421]

Drug(s) Affected By Solute carrier family 35 member F1 (SLC35F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[94]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[99]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[82]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]

Drug(s) Affected By Tau-tubulin kinase 1 (TTBK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[196]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[196]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[94]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[82]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[21]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[100]

Drug(s) Affected By Terminal nucleotidyltransferase 5C (TENT5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[399]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[396]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]

Drug(s) Affected By FERM and PDZ domain-containing protein 2 (FRMPD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[75]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[422]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[423]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[424]

Drug(s) Affected By Actin-binding LIM protein 2 (ABLIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[425]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[100]

Drug(s) Affected By Protein FAM171B (FAM171B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[427]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[10]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[90]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[404]

Drug(s) Affected By Lysophospholipase D GDPD3 (GDPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[351]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[352]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[351]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[353]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[353]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[351]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[349]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[75]
Haloperidol	DM96SE0	Delirium		Approved	[353]

Drug(s) Affected By Regulator of DNA class I crossover intermediates 1 (REDIC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[422]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[422]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM50 (TRIM50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[428]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[428]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[325]

Drug(s) Affected By Inactive serine/threonine-protein kinase TEX14 (TEX14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[47]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[281]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[10]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[404]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[429]

Drug(s) Affected By Dynein regulatory complex subunit 7 (DRC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[104]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[393]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM22 (TRIM22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[279]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[396]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[54]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[430]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Dermatan-sulfate epimerase-like protein (DSEL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]

Drug(s) Affected By N-acetylglutamate synthase, mitochondrial (NAGS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[325]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[49]

Drug(s) Affected By Protein mab-21-like 3 (MAB21L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]

Drug(s) Affected By Dynein axonemal assembly factor 3 (DNAAF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[431]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[104]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[96]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[94]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[82]

Drug(s) Affected By Protein FAM181A (FAM181A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]

Drug(s) Affected By Mixed lineage kinase domain-like protein (MLKL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[235]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[432]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[433]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[434]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[56]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[325]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]

Drug(s) Affected By Transmembrane protein 229B (TMEM229B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[435]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[93]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[94]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[436]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]

Drug(s) Affected By Arrestin domain-containing protein 4 (ARRDC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[431]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[437]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[16]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]

Drug(s) Affected By Transcription factor MafA (MAFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[82]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
Harmine	DMPA5WD	Discovery agent	N.A.	Patented	[438]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[100]
Tributylstannanyl	DMHN7CB	Discovery agent	N.A.	Investigative	[439]

Drug(s) Affected By Phosphoethanolamine/phosphocholine phosphatase (PHOSPHO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[440]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[47]
Lansoprazole	DMXYLQ3	Gastric ulcer	DA60	Approved	[440]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[429]

Drug(s) Affected By Secreted and transmembrane protein 1 (SECTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[75]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[324]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[340]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[441]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[49]

Drug(s) Affected By Cholesterol transporter ABCA5 (ABCA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[442]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[443]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[444]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[10]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]

Drug(s) Affected By Ubiquitin carboxyl-terminal hydrolase BAP1 (BAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[70]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[445]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[446]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[447]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[101]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[448]

Drug(s) Affected By Liver-expressed antimicrobial peptide 2 (LEAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[425]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[56]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[219]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[325]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[20]

Drug(s) Affected By Terminal nucleotidyltransferase 5B (TENT5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[60]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[329]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[225]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]

Drug(s) Affected By Dapper homolog 3 (DACT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[225]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[449]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[96]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]

Drug(s) Affected By Proline-rich AKT1 substrate 1 (AKT1S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[365]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[430]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Cabazitaxel	DMPAZHC	Breast cancer	2C60-2C65	Approved	[450]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[451]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]

Drug(s) Affected By Hepatitis A virus cellular receptor 1 (HAVCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[452]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[453]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[454]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[455]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[456]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[457]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[73]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[417]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]

Drug(s) Affected By Aurora kinase B (AURKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[124]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[166]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[204]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[75]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[324]

Drug(s) Affected By Carboxypeptidase B2 (CPB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[458]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[459]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[325]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[460]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]

Drug(s) Affected By Apoptosis-inducing factor 3 (AIFM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[461]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[82]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[462]

Drug(s) Affected By CUB and sushi domain-containing protein 1 (CSMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Methamphetamine	DMPM4SK	Anxiety		Approved	[463]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[100]

Drug(s) Affected By Tetraspanin-32 (TSPAN32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[231]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[94]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[436]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[15]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[464]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[465]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[466]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[432]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[464]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[465]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[467]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]

Drug(s) Affected By TSC22 domain family protein 3 (TSC22D3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[468]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[399]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[469]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[470]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[396]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[471]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[430]

Drug(s) Affected By Endosomal/lysosomal proton channel TMEM175 (TMEM175)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[404]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[472]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[100]

Drug(s) Affected By Mitochondrial ornithine transporter 2 (SLC25A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[473]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[474]

Drug(s) Affected By Keratin-associated protein 3-1 (KRTAP3-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[18]

Drug(s) Affected By Linker for activation of T-cells family member 2 (LAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[475]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[82]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[476]

Drug(s) Affected By Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[349]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[60]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[324]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[55]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[401]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[477]

Drug(s) Affected By 2-aminomuconic semialdehyde dehydrogenase (ALDH8A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[478]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[479]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[478]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[56]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[219]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[325]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[477]

Drug(s) Affected By Regulating synaptic membrane exocytosis protein 4 (RIMS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[90]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[326]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[100]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[421]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[480]

Drug(s) Affected By Rho-related GTP-binding protein RhoJ (RHOJ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[481]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[10]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[481]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[404]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[482]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[462]

Drug(s) Affected By Protein TANC2 (TANC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[483]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[105]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[392]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[49]

Drug(s) Affected By Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[235]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[484]

Drug(s) Affected By Ras-related protein Rab-6B (RAB6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[50]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]

Drug(s) Affected By Solute carrier family 22 member 11 (SLC22A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[485]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[485]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[56]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[485]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[485]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[486]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[485]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[487]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[485]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[488]

Drug(s) Affected By Transmembrane protein 74B (TMEM74B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[96]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[49]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[2]

Drug(s) Affected By Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[445]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[196]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[48]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[10]

Drug(s) Affected By Rhomboid-related protein 2 (RHBDL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[281]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[489]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[422]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[490]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]

Drug(s) Affected By Sphingomyelin phosphodiesterase 3 (SMPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[491]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[492]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[492]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[94]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]

Drug(s) Affected By Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[264]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[493]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]

Drug(s) Affected By Signal-induced proliferation-associated 1-like protein 2 (SIPA1L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[75]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[324]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[324]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[494]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[324]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[103]

Drug(s) Affected By Dynein axonemal heavy chain 17 (DNAH17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[10]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]

Drug(s) Affected By 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[465]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[199]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[465]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[235]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[465]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[495]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[10]

Drug(s) Affected By Protein EFR3 homolog B (EFR3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[338]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[338]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[477]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[496]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[435]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[497]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[476]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (PPP2R2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[498]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[499]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[500]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[501]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[502]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[49]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[162]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[500]

Drug(s) Affected By Choline-phosphate cytidylyltransferase B (PCYT1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[83]

Drug(s) Affected By Tolloid-like protein 2 (TLL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[387]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[79]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[392]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[503]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[11]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[69]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[392]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bromodomain and extraterminal domain protein (BET)	TTE4BSY	NOUNIPROTAC	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (PLCH2)	OTYERO80	PLCH2_HUMAN	Gene/Protein Processing	[2]
2-aminomuconic semialdehyde dehydrogenase (ALDH8A1)	OTINY3MW	AL8A1_HUMAN	Gene/Protein Processing	[2]
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 (FUT6)	OTBZUQ7F	FUT6_HUMAN	Gene/Protein Processing	[2]
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1)	OTRI4UR1	CP8B1_HUMAN	Gene/Protein Processing	[2]
Actin-binding LIM protein 2 (ABLIM2)	OT62KOXF	ABLM2_HUMAN	Gene/Protein Processing	[2]
Alanine--glyoxylate aminotransferase (AGXT)	OTIPTH3Q	AGT1_HUMAN	Gene/Protein Processing	[2]
Aldo-keto reductase family 1 member D1 (AKR1D1)	OTBDJ6RL	AK1D1_HUMAN	Gene/Protein Processing	[2]
Alpha-internexin (INA)	OT1D33T4	AINX_HUMAN	Gene/Protein Processing	[2]
Alpha-L-iduronidase (IDUA)	OTTQQ7FN	IDUA_HUMAN	Gene/Protein Processing	[2]
Apolipoprotein L3 (APOL3)	OT95SQHR	APOL3_HUMAN	Gene/Protein Processing	[2]

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