Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMI0V4O)

• Drug Name: bilirubin Drug Info
• Synonyms: bilirubin; 635-65-4; Hematoidin; Hemetoidin; Principal bile pigment; UNII-RFM9X3LJ49; Bilirubin IXalpha; Bilirubin IX-alpha; EINECS 211-239-7; NSC 26685; BRN 0074376; RFM9X3LJ49; AI3-23078; 21H-Biline-8,12-dipropanoic acid, 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-; CHEBI:16990; BPYKTIZUTYGOLE-IFADSCNNSA-N; PHEOPHYTIN; MFCD00005499; Bilirubin, 99%; Biline-8,12-dipropionic acid, 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5280352
  ChEBI ID: CHEBI:16990
  CAS Number: CAS 635-65-4
  TTD Drug ID: DMI0V4O
  VARIDT Drug ID: DR00252
  INTEDE Drug ID: DR1980

Molecule-Related Drug Atlas

Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[8]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[10]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[11]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[12]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[13]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[14]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[15]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[16]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[17]

Drug(s) Transported By Organic anion transporting polypeptide 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[19]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[20]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[21]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[20]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[22]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[23]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[24]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[25]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[22]

Drug(s) Transported By Organic anion transporting polypeptide 1B3 (SLCO1B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[20]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[27]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[28]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[20]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[29]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[23]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[25]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[30]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[25]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A6 (UGT1A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[33]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[36]
Naproxen	DMZ5RGV	Bursitis		Approved	[37]
Deferiprone	DMS2M7O	Beta thalassemia	3A50.2	Approved	[38]
ANDROSTERONE	DMITJAK	N. A.	N. A.	Phase 3	[4]
BCP-13498	DM2BO9W	N. A.	N. A.	Phase 2	[39]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[40]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[41]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[42]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[45]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[46]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[46]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[47]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[48]

Drug(s) Affected By Glutathione S-transferase A1 (GSTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[49]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[50]
Thiotepa	DMIZKOP	Breast cancer	2C60-2C65	Approved	[51]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[56]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[59]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[60]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[61]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[62]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[63]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[64]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[65]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[66]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[67]

Drug(s) Affected By Glutathione S-transferase A2 (GSTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[68]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[73]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[57]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[75]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[76]

Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[77]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[63]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[62]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[78]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[79]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[63]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[80]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[62]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[63]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[81]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[82]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[83]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[84]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[85]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[86]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[87]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[88]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[89]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[90]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[91]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[91]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[92]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[94]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[91]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[91]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[91]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[95]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[96]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[101]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[102]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]

Drug(s) Affected By Solute carrier family 23 member 2 (SLC23A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[106]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[107]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[111]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[113]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[114]

Drug(s) Affected By Solute carrier family 23 member 1 (SLC23A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[115]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[105]
Taurocholic Acid	DM2LZ8F	Type-2 diabetes	5A11	Phase 1/2	[111]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]

Drug(s) Affected By Interferon-related developmental regulator 1 (IFRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[119]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[120]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[121]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[122]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[116]

Drug(s) Affected By C-X-C motif chemokine 11 (CXCL11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[127]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[130]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[131]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[131]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[132]

Drug(s) Affected By Etoposide-induced protein 2.4 homolog (EI24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[122]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[135]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[136]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[136]

Drug(s) Affected By Tripeptidyl-peptidase 1 (TPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[140]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[142]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[143]

Drug(s) Affected By Glutathione S-transferase A4 (GSTA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[146]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[147]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[143]

Drug(s) Affected By Leptin receptor gene-related protein (LEPROT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[127]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[148]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[149]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[130]

Drug(s) Affected By Tapasin (TAPBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[150]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[152]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[153]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[148]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[154]

Drug(s) Affected By Myelin protein zero-like protein 2 (MPZL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[153]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[155]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[143]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[158]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[127]

Drug(s) Affected By Transcription factor Maf (MAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[163]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[164]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[165]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[166]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[57]

Drug(s) Affected By E3 SUMO-protein ligase PIAS1 (PIAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[167]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[127]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[167]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[168]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[163]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[138]

Drug(s) Affected By Carboxypeptidase D (CPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[122]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[169]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[112]

Drug(s) Affected By Endonuclease domain-containing 1 protein (ENDOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[172]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[174]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[175]

Drug(s) Affected By Rho-related BTB domain-containing protein 3 (RHOBTB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[122]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[177]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[178]

Drug(s) Affected By Collagen alpha-1(III) chain (COL3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[181]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[183]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[184]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[185]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[186]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[187]

Drug(s) Affected By C-X-C motif chemokine 10 (CXCL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[190]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[191]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[192]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[194]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[195]
Haloperidol	DM96SE0	Delirium		Approved	[196]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[197]
Selenium	DM25CGV	N. A.	N. A.	Approved	[198]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[199]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]

Drug(s) Affected By Annexin A1 (ANXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[202]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[203]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[205]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[124]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[206]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[207]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[203]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]

Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[209]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[190]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[210]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[211]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[212]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[213]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[214]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[215]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[216]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[217]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[218]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[219]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[220]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[190]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[222]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[223]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[224]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[225]

Drug(s) Affected By Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[153]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[226]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[228]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[229]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[231]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[233]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[234]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[151]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[235]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[236]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[237]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[238]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[239]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[240]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[241]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[242]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[243]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[244]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[237]

Drug(s) Affected By Gelsolin (GSN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[127]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[246]

Drug(s) Affected By Laminin subunit beta-1 (LAMB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[248]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[153]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[249]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[250]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[251]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[252]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[252]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[253]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[255]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[256]

Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[251]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[257]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[258]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[259]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[260]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[260]
Methyldopa	DM5I621	Hypertension	BA00-BA04	Approved	[261]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[127]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[127]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[262]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[263]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[239]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[264]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[241]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[265]
Selenium	DM25CGV	N. A.	N. A.	Approved	[266]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[267]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[268]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[159]

Drug(s) Affected By Pro-cathepsin H (CTSH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[270]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[271]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[146]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[113]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[164]

Drug(s) Affected By Histone H1.4 (H1-4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[272]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[249]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[148]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[273]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[274]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[275]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[276]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[277]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[255]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[278]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[279]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[280]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[281]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[282]

Drug(s) Affected By Lysosome-associated membrane glycoprotein 2 (LAMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[284]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[285]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[286]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[258]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[161]

Drug(s) Affected By Delta-aminolevulinic acid dehydratase (ALAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[287]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[288]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[287]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[289]
Mestranol	DMG3F94	Contraception	QA21	Approved	[287]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[287]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[290]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[143]

Drug(s) Affected By Nidogen-1 (NID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[248]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[291]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[292]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[293]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[294]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]

Drug(s) Affected By Leukemia inhibitory factor (LIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[295]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[296]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[298]

Drug(s) Affected By Fos-related antigen 1 (FOSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[101]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[299]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[300]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[301]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[124]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[302]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[71]

Drug(s) Affected By Amphiregulin (AREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[303]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[295]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[305]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[287]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[299]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[306]

Drug(s) Affected By Transcription factor 4 (TCF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[150]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[307]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[308]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[271]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[307]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[309]

Drug(s) Affected By Insulin-like growth factor-binding protein 3 (IGFBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[150]
Selenium	DM25CGV	N. A.	N. A.	Approved	[310]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[311]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[312]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[260]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[313]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[314]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[315]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[263]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[295]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[316]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[317]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[318]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[319]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[320]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[167]

Drug(s) Affected By C-X-C motif chemokine 2 (CXCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Selenium	DM25CGV	N. A.	N. A.	Approved	[321]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[120]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[237]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[322]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[323]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[298]

Drug(s) Affected By Sterol carrier protein 2 (SCP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[324]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[325]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[320]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[82]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]

Drug(s) Affected By NAD-dependent malic enzyme, mitochondrial (ME2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[326]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[148]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[327]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[328]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[329]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[330]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[331]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[332]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[333]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[334]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[335]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[336]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[337]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[338]

Drug(s) Affected By DnaJ homolog subfamily B member 1 (DNAJB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[263]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[340]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[121]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[167]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[101]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[341]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[342]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[302]

Drug(s) Affected By Protein S100-A4 (S100A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[122]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[343]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[344]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[345]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[186]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[346]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[347]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[348]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[344]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[213]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[349]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]

Drug(s) Affected By CAP-Gly domain-containing linker protein 1 (CLIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[350]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[57]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[250]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[174]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[351]

Drug(s) Affected By Ribonuclease 4 (RNASE4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[320]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[352]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[353]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[174]

Drug(s) Affected By Prohibitin 1 (PHB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[171]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[354]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[355]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[354]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[324]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[263]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[357]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[157]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[358]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[276]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[295]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[278]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[359]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[360]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]

Drug(s) Affected By Choline kinase alpha (CHKA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[158]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]

Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[361]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[362]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[361]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[318]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[363]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[364]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[365]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[362]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[366]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[367]

Drug(s) Affected By Isocitrate dehydrogenase , mitochondrial (IDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[368]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[369]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[370]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[153]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[146]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[371]

Drug(s) Affected By RNA-binding protein 5 (RBM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[289]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[148]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[289]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[372]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[138]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[373]

Drug(s) Affected By Protein S100-A10 (S100A10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[374]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[345]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[127]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[375]

Drug(s) Affected By Histone H4 (H4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[295]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[316]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[376]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[205]

Drug(s) Affected By Histone H2B type 1-C/E/F/G/I (H2BC10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[298]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[377]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[113]

Drug(s) Affected By Biogenesis of lysosome-related organelles complex 1 subunit 1 (BLOC1S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[378]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[379]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[380]

Drug(s) Affected By Peripheral myelin protein 22 (PMP22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[213]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[152]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[293]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[381]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[382]

Drug(s) Affected By Prolow-density lipoprotein receptor-related protein 1 (LRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[205]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[383]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[384]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[385]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[249]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[146]

Drug(s) Affected By Peroxiredoxin-4 (PRDX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[386]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[387]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[388]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[389]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[390]

Drug(s) Affected By Methanethiol oxidase (SELENBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[391]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[392]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[146]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[293]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[392]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[392]

Drug(s) Affected By NAD(P) transhydrogenase, mitochondrial (NNT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[213]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[171]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[146]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[393]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[393]

Drug(s) Affected By Nuclear nucleic acid-binding protein C1D (C1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[150]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[394]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[373]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[395]

Drug(s) Affected By RNA-binding protein 39 (RBM39)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[174]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[289]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[149]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[396]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[394]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[329]

Drug(s) Affected By Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[263]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[157]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[397]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[101]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[342]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[398]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[399]

Drug(s) Affected By kinase isozyme 1, mitochondrial (PDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[400]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[400]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[401]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[402]

Drug(s) Affected By Serum paraoxonase/arylesterase 2 (PON2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[403]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[404]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[405]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[178]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]

Drug(s) Affected By Microtubule-associated protein RP/EB family member 2 (MAPRE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[203]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[203]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[400]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[400]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[406]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[373]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[407]

Drug(s) Affected By Dual specificity protein phosphatase 5 (DUSP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[408]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[404]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[409]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[124]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[127]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[400]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]

Drug(s) Affected By Glutathione S-transferase A3 (GSTA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[147]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[57]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[101]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[75]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[410]

Drug(s) Affected By Protein C-mannosyl-transferase DPY19L1 (DPY19L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[161]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[258]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[329]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[411]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[412]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[130]

Drug(s) Affected By Rho GTPase-activating protein 29 (ARHGAP29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[318]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[407]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[203]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[298]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[375]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]

Drug(s) Affected By Phospholipase A1 member A (PLA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[130]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[320]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[153]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[373]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[130]
GW7647	DM9RD0C	Discovery agent	N.A.	Investigative	[413]

Drug(s) Affected By Very-long-chain (HACD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[365]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[148]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[414]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[415]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[416]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[395]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[152]

Drug(s) Affected By Transcription factor Sp5 (SP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[291]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[352]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[57]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[161]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[417]

Drug(s) Affected By Dermokine (DMKN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[186]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[298]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[293]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[326]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[417]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[406]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[418]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[373]

Drug(s) Affected By Monocarboxylate transporter 12 (SLC16A12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[107]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[148]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[414]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[419]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[373]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[420]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[421]

Drug(s) Affected By Histone H3.2 (H3C13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[422]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[148]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[423]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[273]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[422]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[394]

Drug(s) Affected By Coiled-coil domain-containing protein 80 (CCDC80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[186]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[424]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[148]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[418]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[161]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[154]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[425]

Drug(s) Affected By Heme A synthase COX15 (COX15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[426]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[371]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[174]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[148]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[415]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[427]

Drug(s) Affected By Histone H2A type 3 (H2AC25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[428]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[429]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[57]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[175]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[430]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[431]

Drug(s) Affected By Protein mono-ADP-ribosyltransferase TIPARP (TIPARP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[272]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[127]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[127]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[71]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[400]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[400]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]

Drug(s) Affected By CD302 antigen (CD302)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[246]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[249]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[293]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[432]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[148]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[258]

Drug(s) Affected By DEP domain-containing mTOR-interacting protein (DEPTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[161]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[433]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[153]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[249]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[293]

Drug(s) Affected By Membrane protein FAM174A (FAM174A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[130]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[150]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[130]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[434]

Drug(s) Affected By Ankyrin repeat and SOCS box protein 13 (ASB13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[175]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[417]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[414]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[431]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[118]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[395]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[435]

Drug(s) Affected By Tribbles homolog 2 (TRIB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[436]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[437]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[146]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[438]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[174]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[439]

Drug(s) Affected By Chloride channel CLIC-like protein 1 (CLCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[440]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[148]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[441]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[138]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[373]

Drug(s) Affected By Microsomal glutathione S-transferase 2 (MGST2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[442]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[146]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[143]

Drug(s) Affected By Transmembrane 9 superfamily member 2 (TM9SF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[171]
Haloperidol	DM96SE0	Delirium		Approved	[171]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[171]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[146]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[174]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[148]

Drug(s) Affected By Sclerostin (SOST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[417]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[414]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[373]

Drug(s) Affected By Hephaestin (HEPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[130]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[249]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[148]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[258]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[161]

Drug(s) Affected By Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[263]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[121]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[443]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[433]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[398]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[443]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[399]

Drug(s) Affected By Sphingosine-1-phosphate phosphatase 1 (SGPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[291]
Bortezomib	DMNO38U	Leukemia		Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[148]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[406]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[154]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[329]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[407]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[152]

Drug(s) Affected By Egl nine homolog 1 (EGLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[444]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[404]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[167]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[377]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[167]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]

Drug(s) Affected By Large ribosomal subunit protein uL18m (MRPL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[378]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[445]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[105]

Drug(s) Affected By Multiple epidermal growth factor-like domains protein 9 (MEGF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[148]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[258]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[406]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[446]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[373]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[395]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[447]

Drug(s) Affected By Ras association domain-containing protein 4 (RASSF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[145]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[293]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 19 (TNFRSF19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[448]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[317]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[186]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[291]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[317]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[352]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[449]

Drug(s) Affected By Post-GPI attachment to proteins factor 2 (PGAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[296]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[146]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[148]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[329]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[407]

Drug(s) Affected By Oxidative stress-induced growth inhibitor 1 (OSGIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[295]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[127]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[127]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[400]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[400]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[400]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[400]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[400]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[400]

Drug(s) Affected By Nocturnin (NOCT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[146]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[450]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[174]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[379]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[148]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[406]

Drug(s) Affected By Aspartyl aminopeptidase (DNPEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[148]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[406]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[451]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[373]

Drug(s) Affected By Glutathione S-transferase kappa 1 (GSTK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[452]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[265]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[453]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[379]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[454]

Drug(s) Affected By Axin-2 (AXIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[300]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[437]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[455]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[146]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[456]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[74]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[457]

Drug(s) Affected By Sorting nexin-14 (SNX14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[417]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[174]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[148]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[458]

Drug(s) Affected By EP300-interacting inhibitor of differentiation 1 (EID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[459]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[148]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[417]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[105]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[329]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[460]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[461]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[462]

Drug(s) Affected By Sestrin-1 (SESN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[194]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[463]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[205]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[272]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[302]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[127]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[127]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[71]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[400]

Drug(s) Affected By Cytochrome P450 2A6 (CYP2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tegafur	DM31ZQM	Solid tumour/cancer	2A00-2F9Z	Approved	[464]
Methoxsalen	DME8FZ9	Cutaneous T-cell lymphoma	2B01	Approved	[465]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[466]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[467]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[468]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[469]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[470]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[471]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[472]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[473]
Fructose	DM43AN2	Vomiting	MD90	Approved	[196]
Ketoprofen	DMRKXPT	Bursitis		Approved	[196]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[474]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[475]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[476]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[477]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[478]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[242]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[316]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[120]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[106]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[121]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[400]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[479]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[480]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[481]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[482]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[483]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[482]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[484]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[485]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[486]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[487]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[488]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[489]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[239]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[490]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[241]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[491]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[194]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[492]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[491]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[276]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[493]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[276]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[494]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[495]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[101]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[276]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[496]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[497]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[498]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[499]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[500]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[475]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[501]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[502]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[503]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[504]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[505]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[368]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[506]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[499]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[507]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[508]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[509]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[498]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[196]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[448]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[475]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[501]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[510]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[511]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[512]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[513]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[514]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[515]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[516]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[517]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[518]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[519]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[448]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[332]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[520]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[521]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[522]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[523]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[524]

Drug(s) Affected By Interleukin-18 (IL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[448]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[525]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[526]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[527]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[298]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[528]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[529]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[528]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[254]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[491]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[288]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[491]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[491]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[237]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[530]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[121]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[491]

Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[531]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[532]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[533]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[534]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[535]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[438]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[536]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[537]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[538]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[538]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[174]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[196]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[539]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[540]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[541]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[542]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[543]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[544]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[545]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[546]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[2]
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[3]
Organic anion transporting polypeptide 1B3 (SLCO1B3)	DT9C1TS	SO1B3_HUMAN	Substrate	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
UDP-glucuronosyltransferase 1A6 (UGT1A6) Main DME	DESD26P	UD16_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Drug Response	[5]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Gene/Protein Processing	[6]
Amphiregulin (AREG)	OTJFOR67	AREG_HUMAN	Gene/Protein Processing	[7]
AN1-type zinc finger protein 2A	OTTG7P8R	ZFN2A_HUMAN	Gene/Protein Processing	[7]
Ankyrin repeat and SOCS box protein 13 (ASB13)	OTTONRCH	ASB13_HUMAN	Gene/Protein Processing	[7]
Annexin A1 (ANXA1)	OT5OFDJC	ANXA1_HUMAN	Gene/Protein Processing	[7]
Aspartyl aminopeptidase (DNPEP)	OT3UQXXV	DNPEP_HUMAN	Gene/Protein Processing	[7]
Axin-2 (AXIN2)	OTRMGQNU	AXIN2_HUMAN	Gene/Protein Processing	[7]
Biogenesis of lysosome-related organelles complex 1 subunit 1 (BLOC1S1)	OT123376	BL1S1_HUMAN	Gene/Protein Processing	[7]
C-X-C motif chemokine 10 (CXCL10)	OTTLQ6S0	CXL10_HUMAN	Gene/Protein Processing	[7]

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