Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU764S)

• Drug Name: Ritonavir Drug Info
• Synonyms: Norvir; RIT; RTV; Norvir Sec; Ritonavir [USAN]; ABT 538; ABT 84538; ABT538; Abbott 84538; A-84538; ABBOTT-84538; ABT-538; DRG-0244; Norvir (TM); Norvir (TN); Ritonavir (JAN/USAN/INN); N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N~2~-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide; 1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate; 5-Thiazolylmethyl ((alphaS)-alpha-((1S,3S)-1-hydroxy-3-((2S)-2-(3-((2-isopropyl-4-thiazolyl)methyl)-3-methylureido)-3-methylbutyramido)-4-phenylbutyl)phenethyl)carbamate; 5-Thiazolylmethyl ((alphaS)-alpha-((1S,3S-1-hydroxy-3-((2S)-2-(3-((2-isopropyl-4-thiazolyl)methyl)-3-methylureido)-3-methylbutyramido)-4-phenylbutyl)phenethyl)carbamate; 538, ABT

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus infection	1C62	Approved	[1]

• Therapeutic Class: Anti-HIV Agents
• Cross-matching ID:
  PubChem CID: 392622
  ChEBI ID: CHEBI:45409
  CAS Number: CAS 155213-67-5
  TTD Drug ID: DMU764S
  VARIDT Drug ID: DR00332
  INTEDE Drug ID: DR1430
  ACDINA Drug ID: D00600

Molecule-Related Drug Atlas

Drug(s) Targeting Human immunodeficiency virus Protease (HIV PR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[17]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[18]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[19]
Amprenavir	DMLMXE0	Human immunodeficiency virus infection	1C62	Approved	[20]
Darunavir	DMN3GCH	Human immunodeficiency virus infection	1C62	Approved	[21]
Tipranavir	DM8HJX6	Human immunodeficiency virus infection	1C62	Approved	[22]
Fosamprenavir	DM4W9B3	Human immunodeficiency virus infection	1C62	Approved	[23]
BI 201335	DM3MXT8	Hepatitis C virus infection	1E51.1	Phase 3	[24]
BMS 650032	DMQI43G	Hepatitis C virus infection	1E51.1	Phase 2	[25]
Danoprevir	DM20MDU	Hepatitis C virus infection	1E51.1	Phase 2	[26]

Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[29]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[30]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[33]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[34]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[35]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[36]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[37]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[40]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[39]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[41]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[43]

Drug(s) Transported By Organic anion transporting polypeptide 2B1 (SLCO2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[44]
L-Glutamic Acid	DM4PUDW	Schizophrenia	6A20	Approved	[45]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[46]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[47]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[48]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[49]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[50]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[51]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[52]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[53]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[55]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[56]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[58]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[59]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[60]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[61]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[55]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[62]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[92]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[112]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[113]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[114]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[114]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[115]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[94]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[116]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[117]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[64]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[58]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[62]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[66]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[67]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[68]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[69]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[70]

Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[71]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[72]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[73]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[8]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[74]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[75]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[77]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[78]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[8]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[92]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[94]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[95]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[96]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[100]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[101]

Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[79]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[8]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[8]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[8]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[80]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[81]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[8]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[8]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[8]
Metronidazole	DMTIVEN	Abscess		Approved	[82]

Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[83]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[80]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[84]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[87]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[88]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[89]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[90]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[91]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[102]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[103]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[104]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[105]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[106]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[107]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[108]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[109]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[110]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Adiponectin (ADIPOQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[11]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[118]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[119]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[11]
Cilazapril	DM4V6JA	Congestive heart failure	BD10	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[11]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[122]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[123]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[124]

Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[126]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[129]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[130]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[131]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[133]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[132]

Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[137]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[142]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[143]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[144]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[145]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[146]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[147]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[148]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[149]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[151]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[152]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[153]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[153]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[153]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[154]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[155]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[156]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[157]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[158]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[159]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[13]

Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[160]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[114]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[113]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[154]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[161]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[114]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[162]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[113]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[114]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[163]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[113]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[102]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[154]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[114]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[156]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[114]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[163]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[13]

Drug(s) Affected By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[164]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[165]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[164]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[165]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[166]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[164]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[164]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[164]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[167]
Dabrafenib	DMX6OE3	Melanoma	2C30	Approved	[168]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[169]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[170]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[170]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[171]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[169]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[170]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[172]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[169]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[173]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[169]

Drug(s) Affected By Fibroblast growth factor 19 (FGF19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[175]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[177]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[178]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[179]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[175]

Drug(s) Affected By C-X-C motif chemokine 10 (CXCL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[182]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[184]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[186]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Selenium	DM25CGV	N. A.	N. A.	Approved	[188]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[189]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[190]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[191]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[192]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[191]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[193]

Drug(s) Affected By Interleukin-7 (IL7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[193]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[194]
Oxymetholone	DMFXUT8	Aplastic anemia	3A70	Approved	[196]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[197]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[198]

Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[148]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[201]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[203]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[204]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[203]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]

Drug(s) Affected By Leukemia inhibitory factor (LIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[186]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[130]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[204]

Drug(s) Affected By C-X-C motif chemokine 2 (CXCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[186]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Selenium	DM25CGV	N. A.	N. A.	Approved	[188]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[189]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[192]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[212]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[204]

Drug(s) Affected By Sterol carrier protein 2 (SCP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[213]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[214]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[215]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[216]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[217]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[218]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[219]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[220]

Drug(s) Affected By Cytochrome P450 7A1 (CYP7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[221]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[189]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[222]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[223]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[224]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[109]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[222]

Drug(s) Affected By Interleukin-32 (IL32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[225]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[202]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[197]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[227]

Drug(s) Affected By MHC class II transactivator (CIITA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[197]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[229]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[231]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[232]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[233]

Drug(s) Affected By C-X-C motif chemokine 5 (CXCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[234]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[177]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[213]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[237]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[238]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[197]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[239]

Drug(s) Affected By Stromal cell-derived factor 1 (CXCL12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[135]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[240]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[241]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[242]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[177]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[240]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[243]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[204]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[244]

Drug(s) Affected By C-C motif chemokine 20 (CCL20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[186]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[246]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[192]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[247]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[209]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[248]

Drug(s) Affected By C-X-C motif chemokine 6 (CXCL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[249]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[250]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[252]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[253]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[254]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[255]

Drug(s) Affected By Hepatic sodium/bile acid cotransporter (SLC10A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[137]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[223]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[217]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[256]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[224]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[257]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]

Drug(s) Affected By Organic solute transporter subunit alpha (SLC51A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[189]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[259]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[247]

Drug(s) Affected By Protein NLRC5 (NLRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[189]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[10]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[218]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[260]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[261]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[220]

Drug(s) Affected By Heat shock protein 105 kDa (HSPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[148]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[263]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[264]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[265]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[266]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[204]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[213]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[214]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[267]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[268]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[224]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[268]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[175]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[270]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]

Drug(s) Affected By 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[175]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[137]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[127]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[271]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[261]

Drug(s) Affected By Transcription factor E2F3 (E2F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[189]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[264]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[274]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[213]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[264]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[275]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[276]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[277]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[278]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[280]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[281]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[282]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[283]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[284]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[285]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[286]

Drug(s) Affected By G1/S-specific cyclin-E2 (CCNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[234]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[277]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[287]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[189]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[288]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[289]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[290]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[291]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[293]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[294]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[293]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[297]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[298]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[299]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[300]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[294]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[295]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[301]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Selenium	DM25CGV	N. A.	N. A.	Approved	[303]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[304]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[305]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[306]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[307]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[308]
Fructose	DM43AN2	Vomiting	MD90	Approved	[13]
Ketoprofen	DMRKXPT	Bursitis		Approved	[13]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[309]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[310]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[311]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[312]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[313]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[314]

Drug(s) Affected By Prelamin-A/C (LMNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[315]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[316]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[317]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[318]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[214]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[13]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[319]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[320]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[321]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[322]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[323]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[324]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[325]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[326]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[327]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[328]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[329]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[330]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[331]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[332]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[333]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[334]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[330]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[335]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[336]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[337]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[338]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[339]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[340]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[341]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[342]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[343]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[344]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[192]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[345]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[186]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[346]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[11]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[314]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[347]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[348]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[349]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[349]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[13]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[350]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[351]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[352]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[353]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[354]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[355]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[356]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[357]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Fructose	DM43AN2	Vomiting	MD90	Approved	[13]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[359]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[360]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[294]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[361]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[362]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[363]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[364]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[365]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[366]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[367]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[368]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[305]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[369]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[370]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[371]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[372]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[373]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[346]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[374]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[375]
Selenium	DM25CGV	N. A.	N. A.	Approved	[376]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[356]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[377]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[186]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[378]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[379]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[280]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[380]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[381]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[380]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[382]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[383]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[384]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[385]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[386]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[387]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[346]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[360]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[245]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[388]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[389]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[390]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[388]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[11]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[148]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[391]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[201]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[203]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[203]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[11]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[392]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[393]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[394]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[395]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[13]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[186]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[396]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[397]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[310]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[398]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[399]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[400]
Selenium	DM25CGV	N. A.	N. A.	Approved	[303]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[401]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[402]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[403]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[404]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[405]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[406]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[407]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[408]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[409]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[409]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[11]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[410]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[411]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[314]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[412]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[413]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[356]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[414]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[234]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[415]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[361]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Selenium	DM25CGV	N. A.	N. A.	Approved	[303]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[281]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[381]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[416]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[282]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[417]

Drug(s) Affected By Beta-galactosidase (GLB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[234]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[418]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[419]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[420]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[213]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[214]
Bendamustine hydrochloride	DMFH15Z	leukaemia	2A60-2B33	Approved	[421]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[372]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[422]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[294]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[423]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[424]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[425]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[426]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[427]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[429]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[415]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[430]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[369]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[417]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[431]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[432]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]

Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[433]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[434]
Methysergide	DM1EF73	Migraine	8A80	Approved	[172]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[189]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[172]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[127]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[435]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[103]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[436]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[437]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[398]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[328]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[438]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[368]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[439]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[304]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[440]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[234]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[415]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[441]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[442]
Selenium	DM25CGV	N. A.	N. A.	Approved	[303]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[381]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[443]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[444]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[402]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[13]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[445]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[446]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[375]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[447]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[448]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[449]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[315]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]

Drug(s) Affected By Retinoblastoma-like protein 1 (RBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[234]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[450]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[189]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[451]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[452]

Drug(s) Affected By Caspase-1 (CASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[446]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[453]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[454]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[347]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[455]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[456]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[457]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[458]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[459]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[460]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[461]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[13]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[462]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[189]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[463]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[464]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[465]
Fructose	DM43AN2	Vomiting	MD90	Approved	[466]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[467]

Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[468]
Selenium	DM25CGV	N. A.	N. A.	Approved	[303]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[469]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[470]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[289]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[471]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[204]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[213]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[472]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[473]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[474]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[475]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[476]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[477]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[478]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[479]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[480]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[481]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[289]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[361]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[278]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[368]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[281]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[482]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[381]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[287]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[13]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[446]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[483]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[484]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[485]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[486]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[189]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[487]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[488]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[406]

Drug(s) Affected By Leptin (LEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[11]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[314]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[489]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[490]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[491]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[11]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[11]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[122]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[492]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[493]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[494]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[495]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[496]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[339]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[497]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[498]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[499]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[500]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[501]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[445]

Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor B (CDKN2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[234]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[301]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[482]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[502]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[503]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[366]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[438]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[482]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[504]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[505]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[331]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[506]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[507]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[508]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[509]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[510]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[511]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[512]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[513]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[514]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[148]
Fructose	DM43AN2	Vomiting	MD90	Approved	[515]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[516]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[517]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[518]

Drug(s) Affected By Cyclin-dependent kinase 3 (CDK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[282]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[282]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[260]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[261]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[519]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[519]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[519]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[520]
Scriptaid	DM9JZ21	Solid tumour/cancer	2A00-2F9Z	Preclinical	[521]

Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[400]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[344]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[367]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[369]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[189]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[522]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[476]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[177]

Drug(s) Affected By Cyclin-dependent kinase 5 (CDK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[523]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[524]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[242]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[525]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[213]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[214]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[526]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[527]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[186]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[441]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[528]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[287]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[369]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[431]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[446]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[398]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[529]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[427]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[315]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[530]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[531]

Drug(s) Affected By Proto-oncogene c-Rel (REL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[375]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[532]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[533]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[452]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[534]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[535]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[536]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[537]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[538]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[342]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[539]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[280]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[540]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[541]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[542]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[148]

Drug(s) Affected By Retinoblastoma-like protein 2 (RBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[543]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[544]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[274]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[545]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[275]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[218]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[260]

Drug(s) Affected By Transcription factor E2F2 (E2F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[186]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[177]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[265]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[209]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[546]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[374]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[294]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[389]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[547]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[548]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[549]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[550]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[551]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[552]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[553]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[554]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[555]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[556]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[557]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[144]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[558]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[559]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[560]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[561]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[562]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[563]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[564]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[346]

Drug(s) Affected By Scavenger receptor class B member 1 (SCARB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[565]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[566]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[567]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[568]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[569]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[570]

Drug(s) Affected By AP-2 complex subunit alpha-2 (AP2A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[214]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[571]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[261]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[125]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[572]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[573]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[574]

Drug(s) Affected By Lipoprotein lipase (LPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[13]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[410]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[314]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[575]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[476]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[576]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[122]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[577]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[122]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human immunodeficiency virus Protease (HIV PR)	TT5FNQT	POL_HV1B1	Inhibitor	[2]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[3]
Organic anion transporting polypeptide 2B1 (SLCO2B1)	DTPFTEQ	SO2B1_HUMAN	Substrate	[4]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[5]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[6]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[7]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[8]
Cytochrome P450 2B6 (CYP2B6)	DEPKLMQ	CP2B6_HUMAN	Substrate	[9]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Substrate	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1)	OTRI4UR1	CP8B1_HUMAN	Gene/Protein Processing	[10]
Adiponectin (ADIPOQ)	OTNX23LE	ADIPO_HUMAN	Gene/Protein Processing	[11]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[12]
AP-2 complex subunit alpha-2 (AP2A2)	OTD1UGUN	AP2A2_HUMAN	Drug Response	[13]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[14]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[15]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Gene/Protein Processing	[14]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[15]
Beta-galactosidase (GLB1)	OTB0TKAG	BGAL_HUMAN	Gene/Protein Processing	[16]
Bile acid receptor (NR1H4)	OTWZLPTB	NR1H4_HUMAN	Gene/Protein Processing	[10]

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