General Information of Drug (ID: DMMJZYC)

Drug Name
CH-223191 Drug Info
Synonyms
301326-22-7; CH 223191; CH223191; UNII-HYE7315Z4C; HYE7315Z4C; CHEMBL1743245; AhR Antagonist; 2-methyl-N-[2-methyl-4-[(2-methylphenyl)diazenyl]phenyl]pyrazole-3-carboxamide; 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide; 2-methyl-N-[2-methyl-4-(2-methylphenyl)azophenyl]-3-pyrazolecarboxamide; (E)-1-methyl-N-(2-methyl-4-(o-tolyldiazenyl)phenyl)-1H-pyrazole-5-carboxamide; 1-methyl-N-{2-methyl-4-[(E)-(2-methylphenyl)diazenyl]phenyl}-1H-pyrazole-5-carboxamide; 2-Methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide; CBDivE_007629; SCHEMBL363547; DTXSID5058698; AOB1977; EX-A771; SYN5007; CHEBI:125508; HMS3412G22; HMS3676G22; HMS3750E07; BCP12814; ZINC4762981; BDBM50525572; MFCD00377884; s7711; SBB081907; STK837883; 2-Methyl-2H-pyrazole-3-carboxylic acid-(2-methyl-4-o-tolyl-azophenyl)-amide; AKOS000629906; AKOS026750492; ZINC100550218; ZINC254429865; CCG-267843; CS-3905; MCULE-3225752823; 1H-Pyrazole-5-carboxamide, 1-methyl-N-(2-methyl-4-((2-methylphenyl)azo)phenyl)-; 1H-Pyrazole-5-carboxamide, 1-methyl-N-(2-methyl-4-(2-(2-methylphenyl)diazenyl)phenyl)-; AC-32878; AS-16374; HY-12684; QC-11824; FT-0696668; X3558; J-017795; BRD-K22314899-001-01-6; Q27216129; Q27280162; 1-methyl-N-{2-methyl-4-[2-(2-methylphenyl)diazen-1-yl]phenyl}-1H-pyrazole-5-carboxamide; N-{2-methyl-4-[(2-methylphenyl)diazenyl]phenyl}(1-methylpyrazol-5-yl)carboxami de
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Investigative [1]
Cross-matching ID
PubChem CID
3091786
ChEBI ID
CHEBI:125508
CAS Number
CAS 301326-22-7
TTD Drug ID
DMMJZYC

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Patented Agent(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [5]
Tapinarof DMRPI2Q Plaque psoriasis EA90.0 Approved [6]
RVT-505 DM3C9F8 Atopic dermatitis EA80 Phase 2 [7]
IK-175 DMDU54Y Urothelial carcinoma 2C92.0 Phase 1 [8]
BAY 2416964 DMD9N12 Solid tumour/cancer 2A00-2F9Z Phase 1 [9]
AT-177 DMJ02RH Ulcerative colitis DD71 Clinical trial [10]
CB7993113 DMJUQ6E Solid tumour/cancer 2A00-2F9Z Preclinical [11]
2-(1H-indole-3,-carbonyl)-thiazole-4-carboxylic acid methyl ester DMIS1G7 Glioma 2A00.0 Preclinical [12]
6-Formylindolo[3,2-b]carbazole DMN84RM Dermatitis EA80-EA89 Investigative [13]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [14]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [15]
Etretinate DM2CZFA Keratosis ED56 Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [17]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [20]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [21]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [22]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [23]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [24]
Etretinate DM2CZFA Keratosis ED56 Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [28]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [29]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [22]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [23]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [31]
Quercetin DM3NC4M Obesity 5B81 Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [28]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [23]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Benzatropine DMF7EXL Parkinsonian disorder Approved [35]
Clozapine DMFC71L Schizophrenia 6A20 Approved [35]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [36]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [20]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [39]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Urethane DM7NSI0 N. A. N. A. Phase 4 [41]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [42]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [44]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [45]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [47]
Clotrimazole DMMFCIH Cutaneous candidiasis 1F23.14 Approved [46]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [48]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [50]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [51]
Bardoxolone methyl DMODA2X Mixed connective tissue disease 4A43.3 Phase 3 [52]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [53]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [54]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [55]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [56]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [58]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
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Drug(s) Affected By Phosphoglucomutase-1 (PGM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [25]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [61]
Panobinostat DM58WKG Chronic graft versus host disease Approved [62]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [63]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [31]
Etretinate DM2CZFA Keratosis ED56 Approved [16]
Methotrexate DM2TEOL Anterior urethra cancer Approved [64]
Quercetin DM3NC4M Obesity 5B81 Approved [65]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [66]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [67]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [23]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hyaluronan synthase 3 (HAS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [68]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [36]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [71]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [72]
Urethane DM7NSI0 N. A. N. A. Phase 4 [41]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [62]
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Drug(s) Affected By Proepiregulin (EREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [73]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [74]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [74]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [74]
Methotrexate DM2TEOL Anterior urethra cancer Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [78]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [74]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [80]
Gefitinib DM15F0X Colon adenocarcinoma Approved [81]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [74]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [74]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [83]
Selenium DM25CGV N. A. N. A. Approved [84]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [85]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [86]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [73]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Etretinate DM2CZFA Keratosis ED56 Approved [88]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [89]
Methotrexate DM2TEOL Anterior urethra cancer Approved [76]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [90]
Quercetin DM3NC4M Obesity 5B81 Approved [91]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [92]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [93]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [95]
Methotrexate DM2TEOL Anterior urethra cancer Approved [76]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Panobinostat DM58WKG Chronic graft versus host disease Approved [62]
Estrone DM5T6US Acne vulgaris ED80 Approved [97]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [98]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [99]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [100]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [101]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [102]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [103]
Ethacrynic acid DM60QMR Edema MG29 Approved [104]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [105]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [106]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [107]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [109]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [109]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [110]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [111]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [112]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [113]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
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Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [114]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [115]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [116]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [117]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [80]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [118]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [83]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [119]
Methotrexate DM2TEOL Anterior urethra cancer Approved [114]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [31]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [120]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [77]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [58]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [121]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [121]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [69]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [123]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [124]
Diazepam DM08E9O Alcohol withdrawal Approved [125]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [126]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [127]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [28]
Isradipine DMA5XGH Hypertension BA00-BA04 Approved [129]
Valdecoxib DMAY7H4 Osteoarthritis FA00-FA05 Approved [130]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fos-related antigen 1 (FOSL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [131]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [132]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [133]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [134]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [135]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [136]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [112]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amphiregulin (AREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Methotrexate DM2TEOL Anterior urethra cancer Approved [139]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [140]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [78]
Estrone DM5T6US Acne vulgaris ED80 Approved [141]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [133]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [142]
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Drug(s) Affected By Catenin alpha-1 (CTNNA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [143]
Selenium DM25CGV N. A. N. A. Approved [31]
Methotrexate DM2TEOL Anterior urethra cancer Approved [139]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [145]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [94]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [145]
Haloperidol DM96SE0 Delirium Approved [35]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [146]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [147]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [148]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [149]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [150]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [151]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [152]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [153]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [154]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [155]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [74]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [156]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [157]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [159]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [160]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [161]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [162]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [113]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [122]
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Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [99]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [163]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [164]
Estrone DM5T6US Acne vulgaris ED80 Approved [165]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [166]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [167]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [168]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [169]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [116]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [170]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [136]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [122]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [122]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [122]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [171]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [172]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [173]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [39]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [174]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [175]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
QUERCITRIN DM1DH96 Discovery agent N.A. Investigative [176]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [177]
Testosterone DM7HUNW Hot flushes GA30 Approved [178]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [122]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [122]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [15]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [179]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [122]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [122]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [122]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levacecarnine hci DMJBOCR Cognitive impairment 6D71 Approved [181]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [58]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [39]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [71]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [182]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Annexin A10 (ANXA10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [183]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [183]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [184]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [33]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [175]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [33]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [45]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [185]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [186]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [186]
Gefitinib DM15F0X Colon adenocarcinoma Approved [187]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [15]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [188]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [189]
Methotrexate DM2TEOL Anterior urethra cancer Approved [64]
Quercetin DM3NC4M Obesity 5B81 Approved [190]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [58]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [191]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Guanine deaminase (GDA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [136]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [184]
Urethane DM7NSI0 N. A. N. A. Phase 4 [41]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [193]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [44]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [61]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [36]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [184]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [147]
Methotrexate DM2TEOL Anterior urethra cancer Approved [194]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [194]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [195]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCN family member 1 (CCN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Methotrexate DM2TEOL Anterior urethra cancer Approved [114]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [196]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [114]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [197]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [113]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Claudin-4 (CLDN4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [198]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [199]
Selenium DM25CGV N. A. N. A. Approved [31]
Methotrexate DM2TEOL Anterior urethra cancer Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [200]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [201]
Panobinostat DM58WKG Chronic graft versus host disease Approved [62]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [69]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [202]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [203]
Fluoxetine DM3PD2C Bipolar depression Approved [204]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [183]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [179]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [205]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [61]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [179]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [206]
Testosterone DM7HUNW Hot flushes GA30 Approved [178]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By MutS protein homolog 5 (MSH5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [207]
Selenium DM25CGV N. A. N. A. Approved [31]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Testosterone DM7HUNW Hot flushes GA30 Approved [178]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [147]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Arsenic DMTL2Y1 N. A. N. A. Approved [208]
Urethane DM7NSI0 N. A. N. A. Phase 4 [41]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [31]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [136]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [63]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Paclitaxel DMLB81S Breast carcinoma Approved [209]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [210]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [48]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [211]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [212]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Panobinostat DM58WKG Chronic graft versus host disease Approved [213]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [36]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [214]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [184]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [215]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear protein 1 (NUPR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [216]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [217]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [218]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [216]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [216]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Fluoxetine DM3PD2C Bipolar depression Approved [216]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [219]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [217]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [178]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [147]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [220]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [50]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [195]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [44]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [221]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [221]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Panobinostat DM58WKG Chronic graft versus host disease Approved [62]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [222]
Ethanol DMDRQZU Chronic pain MG30 Approved [223]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [214]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [215]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TIP41-like protein (TIPRL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Testosterone enanthate DMB6871 N. A. N. A. Approved [224]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [225]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [226]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [45]
Milchsaure DM462BT Pruritus EC90 Investigative [227]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Stanniocalcin-2 (STC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [131]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [120]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [68]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [177]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [228]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [31]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [230]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [231]
Testosterone DM7HUNW Hot flushes GA30 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [232]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [36]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [233]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [203]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Panobinostat DM58WKG Chronic graft versus host disease Approved [62]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [202]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Menthol DMG2KW7 Back pain ME84.Z Approved [234]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catalase (CAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [235]
Haloperidol DM96SE0 Delirium Approved [15]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [236]
Selenium DM25CGV N. A. N. A. Approved [237]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [238]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [239]
Methotrexate DM2TEOL Anterior urethra cancer Approved [240]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [241]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin receptor (INSR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [242]
Methotrexate DM2TEOL Anterior urethra cancer Approved [240]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Testosterone DM7HUNW Hot flushes GA30 Approved [243]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [172]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [244]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [245]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [246]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [247]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Etretinate DM2CZFA Keratosis ED56 Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Testosterone DM7HUNW Hot flushes GA30 Approved [248]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [146]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [23]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [172]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [249]
Bortezomib DMNO38U Leukemia Approved [250]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [251]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [228]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [252]
Gefitinib DM15F0X Colon adenocarcinoma Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Selenium DM25CGV N. A. N. A. Approved [31]
Etretinate DM2CZFA Keratosis ED56 Approved [16]
Methotrexate DM2TEOL Anterior urethra cancer Approved [240]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [103]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [253]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [254]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [255]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [116]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [256]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [80]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [74]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [257]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [74]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bosutinib DMTI8YE Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [258]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [259]
Methotrexate DM2TEOL Anterior urethra cancer Approved [240]
Quercetin DM3NC4M Obesity 5B81 Approved [260]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [261]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [262]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [263]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [263]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [120]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [121]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [121]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [69]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [121]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [222]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Syndecan-1 (SDC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [264]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [265]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [202]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [266]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [39]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [267]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [228]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [120]
Methotrexate DM2TEOL Anterior urethra cancer Approved [213]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [196]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [268]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [183]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [27]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [72]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [194]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [194]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
Calphostin C DM9X2D0 N. A. N. A. Terminated [269]
Drug(s) Affected By CCN family member 2 (CCN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [155]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [131]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [183]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [114]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [270]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [136]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [228]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [31]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [28]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [271]
Testosterone enanthate DMB6871 N. A. N. A. Approved [224]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [14]
Arsenic DMTL2Y1 N. A. N. A. Approved [208]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [174]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [215]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [228]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [272]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [252]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [273]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [274]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [138]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [275]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [276]
Methotrexate DM2TEOL Anterior urethra cancer Approved [212]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [277]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [278]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Folic Acid DMEMBJC Colorectal carcinoma Approved [279]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [39]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [139]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Urethane DM7NSI0 N. A. N. A. Phase 4 [41]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [44]
PMID28870136-Compound-48 DMPIM9L N. A. N. A. Patented [280]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [45]
Plumbagin DM9BS50 Discovery agent N.A. Investigative [281]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [282]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [116]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [143]
Selenium DM25CGV N. A. N. A. Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [283]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [284]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [136]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [69]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [58]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [27]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [122]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [122]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [122]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [27]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [285]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [112]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [247]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [14]
Indomethacin DMSC4A7 Bursitis Approved [286]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [124]
Selenium DM25CGV N. A. N. A. Approved [31]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [287]
Panobinostat DM58WKG Chronic graft versus host disease Approved [62]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [69]
Testosterone DM7HUNW Hot flushes GA30 Approved [178]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [113]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [288]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [289]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [31]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [226]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [44]
3R14S-OCHRATOXIN A DM2KEW6 Discovery agent N.A. Investigative [290]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [252]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [160]
Testosterone DM7HUNW Hot flushes GA30 Approved [178]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Capsaicin DMGMF6V Back pain ME84.Z Approved [291]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [292]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ephrin-A4 (EFNA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [146]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [293]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [220]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [294]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [77]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [295]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [296]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [197]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [112]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein jagged-1 (JAG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Methotrexate DM2TEOL Anterior urethra cancer Approved [297]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [179]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [162]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [62]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [298]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [285]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [299]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [160]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [27]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [300]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [69]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [301]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [63]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Septin-2 (SEPTIN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [146]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [302]
[3H]methyltrienolone DMTSGOW Discovery agent N.A. Investigative [303]
ELLAGIC ACID DMX8BS5 Discovery agent N.A. Investigative [304]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By P2Y purinoceptor 6 (P2RY6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [305]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [293]
Arsenic DMTL2Y1 N. A. N. A. Approved [306]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
Urethane DM7NSI0 N. A. N. A. Phase 4 [41]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [307]
QUERCITRIN DM1DH96 Discovery agent N.A. Investigative [176]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [31]
Methotrexate DM2TEOL Anterior urethra cancer Approved [139]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [59]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [113]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [146]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [308]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [308]
Arsenic DMTL2Y1 N. A. N. A. Approved [208]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein TGIF1 (TGIF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [160]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [309]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [206]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [310]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [311]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [184]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [147]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [36]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [233]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [312]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
Urethane DM7NSI0 N. A. N. A. Phase 4 [41]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [120]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [183]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [179]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [313]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [136]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [147]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Clozapine DMFC71L Schizophrenia 6A20 Approved [35]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [314]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [195]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [36]
Arsenic DMTL2Y1 N. A. N. A. Approved [208]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [184]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [195]
Urethane DM7NSI0 N. A. N. A. Phase 4 [41]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [231]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [113]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [266]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [63]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [146]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [172]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [44]
Milchsaure DM462BT Pruritus EC90 Investigative [227]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [172]
⏷ Show the Full List of 6 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Ethanol DMDRQZU Chronic pain MG30 Approved [223]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [183]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [36]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [315]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [315]
Estriol DMOEM2I Hormone deficiency 5A61.1 Approved [315]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [293]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Testosterone DM7HUNW Hot flushes GA30 Approved [178]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [36]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [293]
Arsenic DMTL2Y1 N. A. N. A. Approved [208]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [316]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [25]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [174]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [226]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [317]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [44]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [221]
Milchsaure DM462BT Pruritus EC90 Investigative [227]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [146]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [184]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [289]
Urethane DM7NSI0 N. A. N. A. Phase 4 [41]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [44]
3R14S-OCHRATOXIN A DM2KEW6 Discovery agent N.A. Investigative [318]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [45]
Drug(s) Affected By Protein FAM43B (FAM43B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [113]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [147]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [305]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [36]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [308]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [308]
Urethane DM7NSI0 N. A. N. A. Phase 4 [41]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [215]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [179]
Testosterone DM7HUNW Hot flushes GA30 Approved [248]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [36]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [184]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [319]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [320]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [139]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [72]
Urethane DM7NSI0 N. A. N. A. Phase 4 [41]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [175]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [321]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Testosterone DM7HUNW Hot flushes GA30 Approved [248]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Bortezomib DMNO38U Leukemia Approved [250]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [322]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [215]
Urethane DM7NSI0 N. A. N. A. Phase 4 [41]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [113]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [323]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [250]
Arsenic DMTL2Y1 N. A. N. A. Approved [208]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [174]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
Urethane DM7NSI0 N. A. N. A. Phase 4 [41]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [324]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [44]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
Drug(s) Affected By Protein FAM24B (FAM24B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [146]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [36]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [62]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [325]
⏷ Show the Full List of 7 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [160]
Panobinostat DM58WKG Chronic graft versus host disease Approved [62]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Benzatropine DMF7EXL Parkinsonian disorder Approved [35]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [14]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [326]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [327]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [36]
Bortezomib DMNO38U Leukemia Approved [250]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [48]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [193]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [221]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [36]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [328]
Drug(s) Affected By Gasdermin-B (GSDMB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [14]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [184]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [72]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [147]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [329]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By F-box only protein 30 (FBXO30)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [231]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [69]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [122]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [122]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [62]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [146]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [62]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [44]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [330]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [172]
⏷ Show the Full List of 8 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [296]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [331]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [332]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [333]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [195]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [333]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [280]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [121]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [121]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [202]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [121]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [247]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [193]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [247]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [195]
Urethane DM7NSI0 N. A. N. A. Phase 4 [41]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [44]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [63]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ataxin-2-like protein (ATXN2L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [146]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [14]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [75]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [331]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [50]
Urethane DM7NSI0 N. A. N. A. Phase 4 [41]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [333]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nectin-2 (NECTIN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [31]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [62]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Benzatropine DMF7EXL Parkinsonian disorder Approved [35]
Clozapine DMFC71L Schizophrenia 6A20 Approved [35]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [184]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [220]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [194]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein TMEPAI (PMEPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [62]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [202]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [122]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [122]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [122]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [122]
Heroin diacetylmorphine DMDBWHY Neurological disorder 6B60 Approved [334]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [36]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [121]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [121]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [146]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [121]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [266]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [14]
Urethane DM7NSI0 N. A. N. A. Phase 4 [41]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [121]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [44]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [335]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Folic Acid DMEMBJC Colorectal carcinoma Approved [279]
Arsenic DMTL2Y1 N. A. N. A. Approved [208]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [336]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [62]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [337]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [172]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [122]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [75]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [338]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [339]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [221]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [221]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [61]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Testosterone enanthate DMB6871 N. A. N. A. Approved [224]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [340]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [324]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [340]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [331]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [226]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
⏷ Show the Full List of 8 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [341]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
Urethane DM7NSI0 N. A. N. A. Phase 4 [41]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [317]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [62]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [36]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [308]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [214]
Arsenic DMTL2Y1 N. A. N. A. Approved [208]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [147]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [215]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [62]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [266]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [177]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [250]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [184]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [195]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [342]
Milchsaure DM462BT Pruritus EC90 Investigative [227]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tribbles homolog 3 (TRIB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [228]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [183]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [121]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [27]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [343]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [121]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [136]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [344]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [69]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [345]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [280]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [283]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [228]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [113]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [146]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [147]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [63]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [346]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [250]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Copine-1 (CPNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [120]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [120]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Clozapine DMFC71L Schizophrenia 6A20 Approved [35]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [36]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [308]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [308]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [31]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [233]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [289]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
⏷ Show the Full List of 6 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [31]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [347]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [75]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [184]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [72]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [308]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [308]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [184]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [348]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [349]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Selenium DM25CGV N. A. N. A. Approved [31]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Testosterone DM7HUNW Hot flushes GA30 Approved [248]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [36]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Arsenic DMTL2Y1 N. A. N. A. Approved [208]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Autophagy protein 5 (ATG5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [350]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [351]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [352]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [353]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [354]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [355]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [356]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [146]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [357]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [215]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [358]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [359]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [75]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [360]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [215]
YM155 DM5Q1W4 Breast cancer 2C60-2C65 Phase 2 [361]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [139]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [136]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [327]
Testosterone enanthate DMB6871 N. A. N. A. Approved [224]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [362]
Arsenic DMTL2Y1 N. A. N. A. Approved [208]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [155]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [94]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [363]
Testosterone DM7HUNW Hot flushes GA30 Approved [178]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein kish-B (TMEM167B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
Urethane DM7NSI0 N. A. N. A. Phase 4 [41]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [342]
Milchsaure DM462BT Pruritus EC90 Investigative [227]
⏷ Show the Full List of 8 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [147]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [194]
Paclitaxel DMLB81S Breast carcinoma Approved [194]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [364]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [194]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [228]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [203]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [264]
Methotrexate DM2TEOL Anterior urethra cancer Approved [297]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [365]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [28]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [177]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [344]
Testosterone DM7HUNW Hot flushes GA30 Approved [248]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [146]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [366]
Arsenic DMTL2Y1 N. A. N. A. Approved [367]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
Urethane DM7NSI0 N. A. N. A. Phase 4 [41]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [215]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [368]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [116]
Selenium DM25CGV N. A. N. A. Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [331]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [215]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [226]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [369]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [177]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [147]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [63]
Clozapine DMFC71L Schizophrenia 6A20 Approved [370]
Menthol DMG2KW7 Back pain ME84.Z Approved [234]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [141]
Estrone DM5T6US Acne vulgaris ED80 Approved [141]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [69]
Testosterone DM7HUNW Hot flushes GA30 Approved [248]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Mestranol DMG3F94 Contraception QA21 Approved [141]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [141]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [371]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [308]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [372]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [359]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [293]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [48]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [226]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]
⏷ Show the Full List of 8 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [297]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [68]
Testosterone DM7HUNW Hot flushes GA30 Approved [178]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [39]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [71]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [308]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Axin-2 (AXIN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Panobinostat DM58WKG Chronic graft versus host disease Approved [62]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [134]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [373]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [47]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [36]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [374]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [375]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [376]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [228]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Testosterone enanthate DMB6871 N. A. N. A. Approved [224]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Clozapine DMFC71L Schizophrenia 6A20 Approved [35]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [377]
Methotrexate DM2TEOL Anterior urethra cancer Approved [240]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [378]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [379]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [380]
Paclitaxel DMLB81S Breast carcinoma Approved [381]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [382]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [383]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [384]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [385]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [386]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [386]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [386]
Capsaicin DMGMF6V Back pain ME84.Z Approved [387]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [388]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [389]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [390]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [391]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [392]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [15]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [357]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [393]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [394]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [395]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [15]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Verapamil DMA7PEW Angina pectoris BA40 Approved [396]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [397]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [398]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [399]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [400]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [401]
Selenium DM25CGV N. A. N. A. Approved [31]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [402]
Etretinate DM2CZFA Keratosis ED56 Approved [403]
Methotrexate DM2TEOL Anterior urethra cancer Approved [404]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [405]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [406]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [407]
Quercetin DM3NC4M Obesity 5B81 Approved [408]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [409]
Methotrexate DM2TEOL Anterior urethra cancer Approved [139]
Quercetin DM3NC4M Obesity 5B81 Approved [410]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [411]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [4]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [247]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [375]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [72]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [412]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [413]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [414]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [380]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [415]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [416]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [417]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [418]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [419]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [420]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [421]
Gefitinib DM15F0X Colon adenocarcinoma Approved [422]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [423]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [424]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [425]
Methotrexate DM2TEOL Anterior urethra cancer Approved [240]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [426]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [427]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [357]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [420]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Verapamil DMA7PEW Angina pectoris BA40 Approved [396]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [207]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [423]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [428]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [143]
Meloxicam DM2AR7L Arthritis FA20 Approved [429]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [430]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [431]
Verapamil DMA7PEW Angina pectoris BA40 Approved [432]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [252]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Selenium DM25CGV N. A. N. A. Approved [31]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [433]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [434]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [435]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [436]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA polymerase kappa (POLK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [146]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [437]
Paclitaxel DMLB81S Breast carcinoma Approved [438]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [40]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [366]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [293]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
Guanine DMIWLJE N. A. N. A. Phase 3 [439]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [324]
MK-886 DMT0O7H Asthma CA23 Discontinued in Phase 2 [440]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aryl hydrocarbon receptor (AHR) TT037IE AHR_HUMAN Antagonist [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2) OTG7NW98 F262_HUMAN Gene/Protein Processing [2]
Acylpyruvase FAHD1, mitochondrial (FAHD1) OTSZJNPR FAHD1_HUMAN Gene/Protein Processing [2]
Adhesion G-protein coupled receptor F1 (ADGRF1) OTRAOBYH AGRF1_HUMAN Gene/Protein Processing [3]
Alanine aminotransferase 2 (GPT2) OTS5VF7N ALAT2_HUMAN Gene/Protein Processing [2]
Alpha-(1,3)-fucosyltransferase 11 (FUT11) OTD0CDN5 FUT11_HUMAN Gene/Protein Processing [2]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Gene/Protein Processing [3]
Amphiregulin (AREG) OTJFOR67 AREG_HUMAN Gene/Protein Processing [3]
Angiopoietin-related protein 4 (ANGPTL4) OTQL5SPX ANGL4_HUMAN Gene/Protein Processing [3]
Annexin A10 (ANXA10) OTA8LWSL ANX10_HUMAN Gene/Protein Processing [3]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [4]

References

1 Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. Mol Pharmacol. 2006 Jun;69(6):1871-8.
2 Adaptive changes in global gene expression profile of lung carcinoma A549 cells acutely exposed to distinct types of AhR ligands. Toxicol Lett. 2018 Aug;292:162-174.
3 The Ah receptor regulates growth factor expression in head and neck squamous cell carcinoma cell lines. Mol Carcinog. 2014 Oct;53(10):765-76.
4 Ligand-independent activation of AhR by hydroquinone mediates benzene-induced hematopoietic toxicity. Chem Biol Interact. 2022 Mar 1;355:109845. doi: 10.1016/j.cbi.2022.109845. Epub 2022 Feb 4.
5 A Phase I study of the angiogenesis inhibitor SU5416 (semaxanib) in solid tumours, incorporating dynamic contrast MR pharmacodynamic end points. Br J Cancer. 2005 Oct 17;93(8):876-83.
6 FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 215272.
7 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
8 Clinical pipeline report, company report or official report of Ikena Oncology.
9 ClinicalTrials.gov (NCT04069026) A First-in-Humans Dose Finding Study for an Aryl Hydrocarbon Receptor Inhibitor (AhRi) in Patients With Advanced Cancer. U.S. National Institutes of Health.
10 Clinical pipeline report, company report or official report of Azora Therapeutics
11 In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo. Mol Pharmacol. 2014 Nov;86(5):593-608.
12 1'H-Indole-3'-Carbonyl-Thiazole-4-Carboxylic Acid Methyl Ester Blocked Human Glioma Cell Invasion via Aryl Hydrocarbon Receptor's Regulation of Cytoskeletal Contraction. Biomed Res Int. 2020 Oct 3;2020:2616930.
13 6-Formylindolo(3,2-b)carbazole induced aryl hydrocarbon receptor activation prevents intestinal barrier dysfunction through regulation of claudin-2 expression. Chem Biol Interact. 2018 May 25;288:83-90.
14 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
15 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
16 Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
17 Quercetin acts via the G3BP1/YWHAZ axis to inhibit glycolysis and proliferation in oral squamous cell carcinoma. Toxicol Mech Methods. 2023 Feb;33(2):141-150. doi: 10.1080/15376516.2022.2103480. Epub 2022 Aug 9.
18 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
19 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
20 Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
21 1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells. Cell Struct Funct. 2005;30(1):1-6. doi: 10.1247/csf.30.1.
22 Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22.
23 Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
24 PGK1 induction by a hydrogen peroxide treatment is suppressed by antioxidants in human colon carcinoma cells. Biosci Biotechnol Biochem. 2008 Jul;72(7):1799-808. doi: 10.1271/bbb.80079. Epub 2008 Jul 7.
25 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
26 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
27 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
28 Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
29 Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain Res. 2008 Jan 29;1191:1-11.
30 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
31 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
32 Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
33 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
34 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
35 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
36 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
37 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
38 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
39 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
40 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
41 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
42 Molecular mechanisms of action of angiopreventive anti-oxidants on endothelial cells: microarray gene expression analyses. Mutat Res. 2005 Dec 11;591(1-2):198-211.
43 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
44 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
45 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
46 Combination of imatinib and clotrimazole enhances cell growth inhibition in T47D breast cancer cells. Chem Biol Interact. 2015 May 25;233:147-56. doi: 10.1016/j.cbi.2015.03.028. Epub 2015 Apr 8.
47 Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
48 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
49 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
50 Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
51 Resveratrol decreases breast cancer cell viability and glucose metabolism by inhibiting 6-phosphofructo-1-kinase. Biochimie. 2013 Jun;95(6):1336-43. doi: 10.1016/j.biochi.2013.02.013. Epub 2013 Feb 27.
52 Synthetic oleanane triterpenoid derivative CDDO-Me disrupts cellular bioenergetics to suppress pancreatic ductal adenocarcinoma via targeting SLC1A5. J Biochem Mol Toxicol. 2022 Nov;36(11):e23192. doi: 10.1002/jbt.23192. Epub 2022 Aug 5.
53 Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
54 Insulin regulation of hexose transport in mouse 3T3-L1 cells expressing the human HepG2 glucose transporter. J Biol Chem. 1990 Nov 25;265(33):20106-16.
55 Effects of troglitazone on cellular differentiation, insulin signaling, and glucose metabolism in cultured human skeletal muscle cells. Biochem Biophys Res Commun. 2001 Jan 26;280(3):664-74. doi: 10.1006/bbrc.2000.4216.
56 Disturbance of cellular glucose transport by two prevalently used fluoroquinolone antibiotics ciprofloxacin and levofloxacin involves glucose transporter type 1. Toxicol Lett. 2009 Jan 30;184(2):81-4. doi: 10.1016/j.toxlet.2008.10.017. Epub 2008 Oct 28.
57 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
58 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
59 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
60 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
61 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
62 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
63 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
64 Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
65 Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis. Int J Cancer. 2004 Mar 20;109(2):220-9. doi: 10.1002/ijc.11692.
66 Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells. Biol Pharm Bull. 2007 Feb;30(2):247-53. doi: 10.1248/bpb.30.247.
67 Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease. Proteomics. 2008 Apr;8(8):1595-607. doi: 10.1002/pmic.200700556.
68 Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
69 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
70 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
71 CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
72 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
73 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
74 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
75 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
76 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
77 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
78 Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo. J Invest Dermatol. 2006 Apr;126(4):732-9. doi: 10.1038/sj.jid.5700202.
79 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
80 ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
81 Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
82 Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
83 (9)-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7-Stimulated Human Coculture. J Pharmacol Exp Ther. 2019 Oct;371(1):191-201. doi: 10.1124/jpet.119.260661. Epub 2019 Aug 5.
84 Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
85 Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. Arch Toxicol. 2018 Jun;92(6):2043-2054. doi: 10.1007/s00204-018-2199-7. Epub 2018 Mar 29.
86 Spironolactone induces apoptosis in human mononuclear cells. Association between apoptosis and cytokine suppression. Apoptosis. 2006 Apr;11(4):573-9. doi: 10.1007/s10495-006-4919-3.
87 Oxidative Stress-Protective and Anti-Melanogenic Effects of Loliolide and Ethanol Extract from Fresh Water Green Algae, Prasiola japonica. Int J Mol Sci. 2018 Sep 18;19(9):2825. doi: 10.3390/ijms19092825.
88 The effects of a novel synthetic retinoid, seletinoid G, on the expression of extracellular matrix proteins in aged human skin in vivo. Clin Chim Acta. 2005 Dec;362(1-2):161-9. doi: 10.1016/j.cccn.2005.06.016. Epub 2005 Aug 1.
89 Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin-1beta in human tendon-derived cells. A potential mechanism of fluoroquinolone-induced tendinopathy. Arthritis Rheum. 2002 Nov;46(11):3034-40. doi: 10.1002/art.10617.
90 Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. Arterioscler Thromb Vasc Biol. 2007 May;27(5):1043-9. doi: 10.1161/ATVBAHA.107.139881. Epub 2007 Feb 15.
91 Quercetin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells through extracellular signal-regulated kinase. Arch Biochem Biophys. 2001 Jul 1;391(1):72-8. doi: 10.1006/abbi.2001.2402.
92 Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans: implication for the adverse effects of cyclooxygenase-2 inhibitors. Clin Pharmacol Ther. 2006 Apr;79(4):303-15. doi: 10.1016/j.clpt.2005.12.306.
93 Interaction between the aryl hydrocarbon receptor and retinoic acid pathways increases matrix metalloproteinase-1 expression in keratinocytes. J Biol Chem. 2004 Jun 11;279(24):25284-93. doi: 10.1074/jbc.M402168200. Epub 2004 Apr 9.
94 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
95 Ramipril inhibits in vitro human mesangial cell proliferation and platelet-derived growth factor expression. Exp Nephrol. 1999 May-Jun;7(3):229-35. doi: 10.1159/000020606.
96 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
97 Atheroprotective effect of estriol and estrone sulfate on human vascular smooth muscle cells. J Steroid Biochem Mol Biol. 2000 Jan-Feb;72(1-2):71-8. doi: 10.1016/s0960-0760(99)00149-1.
98 Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42.
99 Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
100 Anti-androgenic effect of 6-formylindolo[3,2-b]carbazole (FICZ) in LNCaP cells is mediated by the aryl hydrocarbon-androgen receptors cross-talk. Steroids. 2020 Jan;153:108508. doi: 10.1016/j.steroids.2019.108508. Epub 2019 Oct 3.
101 Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition. Arch Toxicol. 2008 Dec;82(12):909-21.
102 Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density. J Bone Miner Res. 2005 Feb;20(2):232-9. doi: 10.1359/JBMR.041110. Epub 2004 Nov 16.
103 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
104 Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 1999 Feb 1;59(3):607-14.
105 Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
106 The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol. Arch Toxicol. 2013 Apr;87(4):633-43.
107 Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Gastroenterology. 2004 Nov;127(5):1436-45.
108 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
109 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
110 [Effects of As2O3 on tissue factor, plasminogen activator inhibitor-1 and -2 expression in NB4, HL-60 and THP-1 cells]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2003 Oct;34(4):645-9.
111 Effects of aspirin on metastasis-associated gene expression detected by cDNA microarray. Acta Pharmacol Sin. 2004 Oct;25(10):1327-33.
112 JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
113 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
114 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
115 Mechanisms of dexamethasone-induced disturbed sleep and fatigue in paediatric patients receiving treatment for ALL. Eur J Cancer. 2010 Jul;46(10):1848-55. doi: 10.1016/j.ejca.2010.03.026. Epub 2010 Apr 17.
116 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
117 Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
118 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
119 Blood cell oxidative stress precedes hemolysis in whole blood-liver slice co-cultures of rat, dog, and human tissues. Toxicol Appl Pharmacol. 2010 May 1;244(3):354-65. doi: 10.1016/j.taap.2010.01.017. Epub 2010 Feb 6.
120 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
121 Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
122 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
123 Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21737-42. doi: 10.1073/pnas.1007863107. Epub 2010 Nov 22.
124 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
125 Patterns of some extracellular matrix gene expression are similar in cells from cleft lip-palate patients and in human palatal fibroblasts exposed to diazepam in culture. Toxicology. 2009 Mar 4;257(1-2):10-6. doi: 10.1016/j.tox.2008.12.002. Epub 2008 Dec 9.
126 Imiquimod: a potential weapon against Dupuytren contracture. Med Hypotheses. 2006;66(5):991-2. doi: 10.1016/j.mehy.2005.09.052. Epub 2005 Dec 20.
127 Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells. PLoS One. 2016 Jan 22;11(1):e0147312. doi: 10.1371/journal.pone.0147312. eCollection 2016.
128 The role of simvastatin in the osteogenesis of injectable tissue-engineered bone based on human adipose-derived stromal cells and platelet-rich plasma. Biomaterials. 2010 Jul;31(20):5325-35. doi: 10.1016/j.biomaterials.2010.03.037. Epub 2010 Apr 9.
129 Proliferation of cultured human gingival fibroblasts caused by isradipine, a dihydropyridine-derivative calcium antagonist. Eur J Med Res. 2004 Jun 30;9(6):313-5.
130 The effect of valdecoxib on the production of growth factors evoked by hypoxia and bacterial lipopolysaccharide in HMEC-1 cells. Adv Clin Exp Med. 2013 Nov-Dec;22(6):795-800.
131 Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
132 Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
133 Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
134 A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
135 Antitumor effect of aspirin in glioblastoma cells by modulation of -catenin/T-cell factor-mediated transcriptional activity. J Neurosurg. 2011 Oct;115(4):780-8. doi: 10.3171/2011.5.JNS113. Epub 2011 Jul 1.
136 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
137 Analysis of estrogen agonism and antagonism of tamoxifen, raloxifene, and ICI182780 in endometrial cancer cells: a putative role for the epidermal growth factor receptor ligand amphiregulin. J Soc Gynecol Investig. 2005 Oct;12(7):e55-67.
138 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
139 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
140 Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. Surgery. 2005 Sep;138(3):415-21. doi: 10.1016/j.surg.2005.06.030.
141 Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
142 Amphiregulin is a vitamin D3 target gene in squamous cell and breast carcinoma. Biochem Biophys Res Commun. 2001 Mar 9;281(4):1051-6. doi: 10.1006/bbrc.2001.4466.
143 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
144 Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
145 Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
146 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
147 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
148 Docosahexaenoic acid regulates gene expression in HUVEC cells treated with polycyclic aromatic hydrocarbons. Toxicol Lett. 2015 Jul 16;236(2):75-81.
149 Etoposide induces necrosis through p53-mediated antiapoptosis in human kidney proximal tubule cells. Toxicol Sci. 2015 Nov;148(1):204-19.
150 Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. Br J Nutr. 2006 Nov;96(5):811-9.
151 COX-2 and PPAR-gama confer cannabidiol-induced apoptosis of human lung cancer cells. Mol Cancer Ther. 2013 Jan;12(1):69-82.
152 Mitochondrial involvement in schizophrenia and other functional psychoses. Neurochem Res. 1996 Sep;21(9):995-1004.
153 Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression. Eur Neuropsychopharmacol. 2007 Dec;17(12):774-80.
154 Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer. Cancer Res. 2006 Feb 15;66(4):2067-73.
155 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
156 A2E selectively induces cox-2 in ARPE-19 and human neural cells. Curr Eye Res. 2006 Mar;31(3):259-63.
157 Investigation of in vitro odonto/osteogenic capacity of cannabidiol on human dental pulp cell. J Dent. 2021 Jun;109:103673. doi: 10.1016/j.jdent.2021.103673. Epub 2021 Apr 16.
158 Naringin protects human adipose-derived mesenchymal stem cells against hydrogen peroxide-induced inhibition of osteogenic differentiation. Chem Biol Interact. 2015 Dec 5;242:255-61. doi: 10.1016/j.cbi.2015.10.010. Epub 2015 Oct 19.
159 Quercetin, a flavonoid, inhibits proliferation and increases osteogenic differentiation in human adipose stromal cells. Biochem Pharmacol. 2006 Nov 15;72(10):1268-78. doi: 10.1016/j.bcp.2006.08.021. Epub 2006 Sep 22.
160 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
161 Glucosamine promotes osteogenic differentiation of dental pulp stem cells through modulating the level of the transforming growth factor-beta type I receptor. J Cell Physiol. 2010 Oct;225(1):140-51.
162 How benzene and its metabolites affect human marrow derived mesenchymal stem cells. Toxicol Lett. 2012 Oct 17;214(2):145-53. doi: 10.1016/j.toxlet.2012.08.015. Epub 2012 Aug 30.
163 Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
164 Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
165 In vitro aromatic bioactivation of the weak estrogen E(2)alpha and genesis of DNA adducts. Steroids. 2005 Mar;70(3):161-72. doi: 10.1016/j.steroids.2004.11.004.
166 Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr;33(4):489-94.
167 Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1. Drug Metab Dispos. 2004 Aug;32(8):840-7.
168 Apoptosis contributes to the cytotoxicity induced by amodiaquine and its major metabolite N-desethylamodiaquine in hepatic cells. Toxicol In Vitro. 2020 Feb;62:104669. doi: 10.1016/j.tiv.2019.104669. Epub 2019 Oct 16.
169 Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. doi: 10.1158/0008-5472.CAN-07-6381.
170 Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
171 Oxidative stress mechanisms do not discriminate between genotoxic and nongenotoxic liver carcinogens. Chem Res Toxicol. 2015 Aug 17;28(8):1636-46.
172 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
173 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
174 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
175 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
176 Molecular mechanisms of quercitrin-induced apoptosis in non-small cell lung cancer. Arch Med Res. 2014 Aug;45(6):445-54.
177 In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
178 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
179 Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
180 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
181 Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters. Exp Hematol. 2011 Apr;39(4):446-56.
182 Multiple drug transporters mediate the placental transport of sulpiride. Arch Toxicol. 2017 Dec;91(12):3873-3884. doi: 10.1007/s00204-017-2008-8. Epub 2017 Jun 9.
183 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
184 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
185 Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
186 Localization of breast cancer resistance protein (Bcrp) in endocrine organs and inhibition of its transport activity by steroid hormones. Cell Tissue Res. 2012 Aug;349(2):551-63. doi: 10.1007/s00441-012-1417-5. Epub 2012 May 13.
187 Pharmacogenetics of ABCG2 and adverse reactions to gefitinib. J Natl Cancer Inst. 2006 Dec 6;98(23):1739-42.
188 ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin. Clin Pharmacol Ther. 2010 May;87(5):558-62.
189 Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
190 Activation of beta-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells. J Neurochem. 2008 Aug;106(4):1855-65. doi: 10.1111/j.1471-4159.2008.05537.x. Epub 2008 Jul 4.
191 Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps. Cancer Biol Ther. 2005 Jul;4(7):747-52.
192 Aberrantly expressed genes in HaCaT keratinocytes chronically exposed to arsenic trioxide. Biomark Insights. 2011 Feb 8;6:7-16.
193 Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
194 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
195 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
196 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
197 Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3767-77.
198 Cannabidiol induces osteoblast differentiation via angiopoietin1 and p38 MAPK. Environ Toxicol. 2020 Dec;35(12):1318-1325. doi: 10.1002/tox.22996. Epub 2020 Jul 13.
199 Testosterone regulates tight junction proteins and influences prostatic autoimmune responses. Horm Cancer. 2011 Jun;2(3):145-56. doi: 10.1007/s12672-010-0063-1.
200 Quercetin enhances epithelial barrier function and increases claudin-4 expression in Caco-2 cells. J Nutr. 2008 Jun;138(6):1067-73. doi: 10.1093/jn/138.6.1067.
201 Troglitazone increases expression of E-cadherin and claudin 4 in human pancreatic cancer cells. Biochem Biophys Res Commun. 2009 Mar 13;380(3):614-9. doi: 10.1016/j.bbrc.2009.01.134. Epub 2009 Jan 27.
202 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
203 MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
204 Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
205 Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
206 Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
207 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
208 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
209 Proteomic analysis of anti-cancer effects by paclitaxel treatment in cervical cancer cells. Gynecol Oncol. 2005 Jul;98(1):45-53. doi: 10.1016/j.ygyno.2005.04.010.
210 Nuclear proteome analysis of cisplatin-treated HeLa cells. Mutat Res. 2010 Sep 10;691(1-2):1-8. doi: 10.1016/j.mrfmmm.2010.06.002. Epub 2010 Jun 9.
211 Proteomic analysis of antiproliferative effects by treatment of 5-fluorouracil in cervical cancer cells. DNA Cell Biol. 2004 Nov;23(11):769-76.
212 Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
213 Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
214 The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
215 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
216 A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
217 Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci. 2007 Mar;96(1):101-14.
218 In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies. Toxicol Sci. 2007 Sep;99(1):162-73.
219 Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
220 Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
221 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
222 The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
223 Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
224 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
225 Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. PLoS One. 2007 Nov 14;2(11):e1187. doi: 10.1371/journal.pone.0001187.
226 Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
227 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
228 Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
229 Role of calcitriol and cortisol on human adipocyte proliferation and oxidative and inflammatory stress: a microarray study. J Nutrigenet Nutrigenomics. 2008;1(1-2):30-48. doi: 10.1159/000109873. Epub 2007 Oct 16.
230 Adipocyte differentiation, mitochondrial gene expression and fat distribution: differences between zidovudine and tenofovir after 6 months. Antivir Ther. 2009;14(8):1089-100. doi: 10.3851/IMP1457.
231 Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
232 Testosterone stimulates adipose tissue 11beta-hydroxysteroid dehydrogenase type 1 expression in a depot-specific manner in children. J Clin Endocrinol Metab. 2010 Jul;95(7):3300-8.
233 Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
234 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
235 Role of antioxidant systems in human androgen-independent prostate cancer cells. Prostate. 2000 May 1;43(2):144-9. doi: 10.1002/(sici)1097-0045(20000501)43:2<144::aid-pros9>3.0.co;2-h.
236 Cytotoxic Effects of Cannabinoids on Human HT-29 Colorectal Adenocarcinoma Cells: Different Mechanisms of THC, CBD, and CB83. Int J Mol Sci. 2020 Aug 1;21(15):5533. doi: 10.3390/ijms21155533.
237 Selenium deficiency alters epithelial cell morphology and responses to influenza. Free Radic Biol Med. 2007 Jun 15;42(12):1826-37.
238 Hepatocellular peroxisomes in human alcoholic and drug-induced hepatitis: a quantitative study. Hepatology. 1991 Nov;14(5):811-7.
239 Antioxidant enzyme and malondialdehyde values in social phobia before and after citalopram treatment. Eur Arch Psychiatry Clin Neurosci. 2004 Aug;254(4):231-5.
240 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
241 The effect of statins on lipids peroxidation and activities of antioxidants enzymes in patients with dyslipidemia. Przegl Lek. 2006;63(9):738-42.
242 Fanconi anemia links reactive oxygen species to insulin resistance and obesity. Antioxid Redox Signal. 2012 Oct 15;17(8):1083-98. doi: 10.1089/ars.2011.4417. Epub 2012 Jun 25.
243 [Testosterone's role in regulating expression of genes of several proliferation factors]. Tsitologiia. 2006;48(10):856-61.
244 Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-kappa B and I kappa B kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro. Endocrinology. 2005 Mar;146(3):1491-7. doi: 10.1210/en.2004-0809. Epub 2004 Nov 24.
245 Methamphetamine exposure upregulates the amyloid precursor protein and hyperphosphorylated tau expression: The roles of insulin signaling in SH-SY5Y cell line. J Toxicol Sci. 2019;44(7):493-503. doi: 10.2131/jts.44.493.
246 Role of phenytoin in wound healing: microarray analysis of early transcriptional responses in human dermal fibroblasts. Biochem Biophys Res Commun. 2004 Feb 13;314(3):661-6. doi: 10.1016/j.bbrc.2003.12.146.
247 Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
248 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
249 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
250 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
251 Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. Pharmacogenet Genomics. 2006 Apr;16(4):287-96. doi: 10.1097/01.fpc.0000189800.88596.7a.
252 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
253 Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
254 Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol. 2012 May;57(5):483-90. doi: 10.1016/j.archoralbio.2011.10.007. Epub 2011 Nov 25.
255 Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
256 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
257 Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med. 2000 Jan;161(1):249-56. doi: 10.1164/ajrccm.161.1.9804096.
258 SKI-606 decreases growth and motility of colorectal cancer cells by preventing pp60(c-Src)-dependent tyrosine phosphorylation of beta-catenin and its nuclear signaling. Cancer Res. 2006 Feb 15;66(4):2279-86. doi: 10.1158/0008-5472.CAN-05-2057.
259 Selective activation of Src family kinases and JNK by low levels of chromium(VI). Toxicol Appl Pharmacol. 2003 Aug 1;190(3):214-23. doi: 10.1016/s0041-008x(03)00188-1.
260 Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling. Biochem Pharmacol. 2014 Feb 1;87(3):424-34. doi: 10.1016/j.bcp.2013.11.008. Epub 2013 Nov 23.
261 Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells. J Biol Chem. 2015 Jun 19;290(25):15799-15811. doi: 10.1074/jbc.M115.641167. Epub 2015 May 11.
262 Mithramycin inhibits human epithelial carcinoma cell proliferation and migration involving downregulation of Eps8 expression. Chem Biol Interact. 2010 Jan 5;183(1):181-6. doi: 10.1016/j.cbi.2009.09.018.
263 The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
264 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
265 Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
266 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
267 The myeloma cell antigen syndecan-1 is lost by apoptotic myeloma cells. Br J Haematol. 1998 Mar;100(4):637-46. doi: 10.1046/j.1365-2141.1998.00623.x.
268 Identification of novel activators of the metal responsive transcription factor (MTF-1) using a gene expression biomarker in a microarray compendium. Metallomics. 2020 Sep 23;12(9):1400-1415. doi: 10.1039/d0mt00071j.
269 Targeting the beta-catenin/TCF transcriptional complex in the treatment of multiple myeloma. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7516-21. doi: 10.1073/pnas.0610299104. Epub 2007 Apr 23.
270 The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells. Chem Biol Interact. 2019 Apr 1;302:28-35. doi: 10.1016/j.cbi.2019.01.033. Epub 2019 Jan 28.
271 Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
272 Induction of CCAAT/enhancer-binding protein-homologous protein by cigarette smoke through the superoxide anion-triggered PERK-eIF2 pathway. Toxicology. 2011 Sep 5;287(1-3):105-12. doi: 10.1016/j.tox.2011.06.005. Epub 2011 Jun 15.
273 Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 2011 Mar;13(3):267-79. doi: 10.1093/neuonc/noq195. Epub 2011 Feb 3.
274 Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
275 High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities. Arch Toxicol. 2017 Mar;91(3):1367-1383. doi: 10.1007/s00204-016-1781-0. Epub 2016 Jun 29.
276 Utilization of causal reasoning of hepatic gene expression in rats to identify molecular pathways of idiosyncratic drug-induced liver injury. Toxicol Sci. 2014 Jan;137(1):234-48. doi: 10.1093/toxsci/kft232. Epub 2013 Oct 17.
277 Copper-transporting P-type adenosine triphosphatase (ATP7B) is associated with cisplatin resistance. Cancer Res. 2000 Mar 1;60(5):1312-6.
278 The loop connecting metal-binding domains 3 and 4 of ATP7B is a target of a kinase-mediated phosphorylation. Biochemistry. 2009 Jun 23;48(24):5573-81. doi: 10.1021/bi900325k.
279 Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
280 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
281 Plumbagin induces paraptosis in cancer cells by disrupting the sulfhydryl homeostasis and proteasomal function. Chem Biol Interact. 2019 Sep 1;310:108733. doi: 10.1016/j.cbi.2019.108733. Epub 2019 Jul 2.
282 Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer. Br J Pharmacol. 2014 Oct;171(19):4464-77. doi: 10.1111/bph.12803. Epub 2014 Sep 5.
283 Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
284 Study of As(2)O(3) regulating proliferation and apoptosis of Tca8113 cells by inhibiting the expression of Id-1. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1932-1937. doi: 10.1080/21691401.2019.1613419.
285 Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
286 Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells. Neoplasia. 2006 Sep;8(9):758-71.
287 The aryl hydrocarbon receptor activates the retinoic acid receptoralpha through SMRT antagonism. Biochimie. 2006 Mar-Apr;88(3-4):387-97. doi: 10.1016/j.biochi.2005.11.007. Epub 2005 Dec 7.
288 Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
289 Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
290 Ochratoxin a lowers mRNA levels of genes encoding for key proteins of liver cell metabolism. Cancer Genomics Proteomics. 2008 Nov-Dec;5(6):319-32.
291 A comparative proteomic analysis for capsaicin-induced apoptosis between human hepatocarcinoma (HepG2) and human neuroblastoma (SK-N-SH) cells. Proteomics. 2008 Nov;8(22):4748-67. doi: 10.1002/pmic.200800094.
292 Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines. Chem Biol Interact. 2010 Oct 6;188(1):214-9.
293 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
294 Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
295 D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
296 Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
297 Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
298 NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
299 Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
300 Gene expression in benzene-exposed workers by microarray analysis of peripheral mononuclear blood cells: induction and silencing of CYP4F3A and regulation of DNA-dependent protein kinase catalytic subunit in DNA double strand break repair. Chem Biol Interact. 2010 Mar 19;184(1-2):207-11.
301 Ouabain induces apoptotic cell death in human prostate DU 145 cancer cells through DNA damage and TRAIL pathways. Environ Toxicol. 2019 Dec;34(12):1329-1339. doi: 10.1002/tox.22834. Epub 2019 Aug 21.
302 Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int. 2021 Nov;156:106730. doi: 10.1016/j.envint.2021.106730. Epub 2021 Jun 27.
303 Evaluation of an in vitro model of androgen ablation and identification of the androgen responsive proteome in LNCaP cells. Proteomics. 2007 Jan;7(1):47-63.
304 Interactive gene expression pattern in prostate cancer cells exposed to phenolic antioxidants. Life Sci. 2002 Mar 1;70(15):1821-39.
305 Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
306 Inorganic arsenic exposure promotes malignant progression by HDAC6-mediated down-regulation of HTRA1. J Appl Toxicol. 2023 Aug;43(8):1214-1224. doi: 10.1002/jat.4457. Epub 2023 Mar 11.
307 Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
308 Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
309 Suppression of TG-interacting factor sensitizes arsenic trioxide-induced apoptosis in human hepatocellular carcinoma cells. Biochem J. 2011 Sep 1;438(2):349-58. doi: 10.1042/BJ20101653.
310 Hepatocyte growth factor receptor signaling mediates the anti-fibrotic action of 9-cis-retinoic acid in glomerular mesangial cells. Am J Pathol. 2005 Oct;167(4):947-57. doi: 10.1016/S0002-9440(10)61185-6.
311 Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
312 In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
313 Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. J Proteome Res. 2009 Jun;8(6):3006-19.
314 In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer. Mol Cancer. 2006 Mar 28;5:13.
315 Identification of estrogen-responsive genes by complementary deoxyribonucleic acid microarray and characterization of a novel early estrogen-induced gene: EEIG1. Mol Endocrinol. 2004 Feb;18(2):402-11. doi: 10.1210/me.2003-0202. Epub 2003 Nov 6.
316 Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 2013 Mar;3(3):308-23.
317 Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
318 Transcriptomic alterations induced by Ochratoxin A in rat and human renal proximal tubular in vitro models and comparison to a rat in vivo model. Arch Toxicol. 2012 Apr;86(4):571-89.
319 Cellular reactions to long-term volatile organic compound (VOC) exposures. Sci Rep. 2016 Dec 1;6:37842. doi: 10.1038/srep37842.
320 A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302. doi: 10.1371/journal.pone.0178302. eCollection 2017.
321 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
322 Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer. Cancer Res. 2006 Mar 1;66(5):2765-77.
323 Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
324 Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
325 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
326 5-Fluorouracil up-regulates interferon pathway gene expression in esophageal cancer cells. Anticancer Res. 2005 Sep-Oct;25(5):3271-8.
327 Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
328 Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
329 The MT1G Gene in LUHMES Neurons Is a Sensitive Biomarker of Neurotoxicity. Neurotox Res. 2020 Dec;38(4):967-978. doi: 10.1007/s12640-020-00272-3. Epub 2020 Sep 1.
330 Bisphenol A and bisphenol S induce distinct transcriptional profiles in differentiating human primary preadipocytes. PLoS One. 2016 Sep 29;11(9):e0163318.
331 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
332 Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. BMC Genomics. 2006 Apr 3;7:68. doi: 10.1186/1471-2164-7-68.
333 Changes in gene expressions elicited by physiological concentrations of genistein on human endometrial cancer cells. Mol Carcinog. 2006 Oct;45(10):752-63.
334 Distinctive profiles of gene expression in the human nucleus accumbens associated with cocaine and heroin abuse. Neuropsychopharmacology. 2006 Oct;31(10):2304-12. doi: 10.1038/sj.npp.1301089. Epub 2006 May 3.
335 Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
336 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
337 Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
338 Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
339 Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands. Toxicol Lett. 2011 Oct 10;206(2):178-88.
340 The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent. Toxicology. 2010 Apr 11;270(2-3):137-49. doi: 10.1016/j.tox.2010.02.008. Epub 2010 Feb 17.
341 Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
342 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
343 Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
344 Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells. Lipids Health Dis. 2010 Jun 2;9:56. doi: 10.1186/1476-511X-9-56.
345 Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. Mol Cell. 2006 Nov 3;24(3):341-54. doi: 10.1016/j.molcel.2006.10.019.
346 Hydrocortisone enhances the barrier properties of HBMEC/ci, a brain microvascular endothelial cell line, through mesenchymal-to-endothelial transition-like effects. Fluids Barriers CNS. 2015 Mar 5;12:7. doi: 10.1186/s12987-015-0003-0. eCollection 2015.
347 Real-time monitoring of cisplatin-induced cell death. PLoS One. 2011;6(5):e19714. doi: 10.1371/journal.pone.0019714. Epub 2011 May 16.
348 Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor alpha signalling and results in tamoxifen insensitive proliferation. BMC Cancer. 2014 Apr 23;14:283.
349 Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
350 EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS One. 2011;6(6):e18691. doi: 10.1371/journal.pone.0018691. Epub 2011 Jun 2.
351 Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy. Oxid Med Cell Longev. 2018 Mar 18;2018:1482795. doi: 10.1155/2018/1482795. eCollection 2018.
352 Arsenic trioxide induces autophagic cell death in osteosarcoma cells via the ROS-TFEB signaling pathway. Biochem Biophys Res Commun. 2018 Jan 29;496(1):167-175. doi: 10.1016/j.bbrc.2018.01.018. Epub 2018 Jan 4.
353 TNF enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy. Toxicol Lett. 2021 May 15;342:73-84. doi: 10.1016/j.toxlet.2021.02.009. Epub 2021 Feb 17.
354 Inhibition of autophagy enhances Hydroquinone-induced TK6 cell death. Toxicol In Vitro. 2017 Jun;41:123-132. doi: 10.1016/j.tiv.2017.02.024. Epub 2017 Mar 2.
355 AMPK activation induced by promethazine increases NOXA expression and Beclin-1 phosphorylation and drives autophagy-associated apoptosis in chronic myeloid leukemia. Chem Biol Interact. 2020 Jan 5;315:108888. doi: 10.1016/j.cbi.2019.108888. Epub 2019 Nov 2.
356 Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe. 2009 Sep 17;6(3):231-43. doi: 10.1016/j.chom.2009.08.004.
357 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
358 Oxidative stress-induced epigenetic changes associated with malignant transformation of human kidney epithelial cells. Oncotarget. 2017 Feb 14;8(7):11127-11143. doi: 10.18632/oncotarget.12091.
359 Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
360 Effects of chronic exposure to arsenic and estrogen on epigenetic regulatory genes expression and epigenetic code in human prostate epithelial cells. PLoS One. 2012;7(8):e43880. doi: 10.1371/journal.pone.0043880. Epub 2012 Aug 27.
361 YM155 as an inhibitor of cancer stemness simultaneously inhibits autophosphorylation of epidermal growth factor receptor and G9a-mediated stemness in lung cancer cells. PLoS One. 2017 Aug 7;12(8):e0182149. doi: 10.1371/journal.pone.0182149. eCollection 2017.
362 Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer. Mol Oncol. 2011 Oct;5(5):438-53. doi: 10.1016/j.molonc.2011.07.003. Epub 2011 Jul 26.
363 Similarities and differences between two modes of antagonism of the thyroid hormone receptor. ACS Chem Biol. 2011 Oct 21;6(10):1096-106.
364 A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia. Nat Genet. 2014 Sep;46(9):1017-20. doi: 10.1038/ng.3060. Epub 2014 Aug 10.
365 Identification of troglitazone responsive genes: induction of RTP801 during troglitazone-induced apoptosis in Hep 3B cells. BMB Rep. 2010 Sep;43(9):599-603. doi: 10.5483/BMBRep.2010.43.9.599.
366 Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
367 Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environ Health Perspect. 2008 Apr;116(4):524-31. doi: 10.1289/ehp.10861.
368 Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
369 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
370 Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids. Toxicol Mech Methods. 2023 Jun;33(5):401-410. doi: 10.1080/15376516.2022.2156005. Epub 2022 Dec 19.
371 DNA methylation inhibits p53-mediated survivin repression. Oncogene. 2009 May 14;28(19):2046-50. doi: 10.1038/onc.2009.62. Epub 2009 Apr 13.
372 Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2011 Feb;123(3-5):140-50.
373 Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
374 Estrogen receptor alpha (ER)-mediated coregulator binding and gene expression discriminates the toxic ER agonist diethylstilbestrol (DES) from the endogenous ER agonist 17-estradiol (E2). Cell Biol Toxicol. 2020 Oct;36(5):417-435. doi: 10.1007/s10565-020-09516-6. Epub 2020 Feb 22.
375 A fine-needle aspirate-based vulnerability assay identifies polo-like kinase 1 as a mediator of gemcitabine resistance in pancreatic cancer. Mol Cancer Ther. 2010 Feb;9(2):311-8. doi: 10.1158/1535-7163.MCT-09-0693. Epub 2010 Jan 26.
376 An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide. Exp Hematol. 2007 Feb;35(2):252-62.
377 p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
378 Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
379 Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
380 Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
381 Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
382 Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. Nucleic Acids Res. 2009 Jan;37(1):78-95. doi: 10.1093/nar/gkn910. Epub 2008 Nov 16.
383 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
384 Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
385 Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
386 In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions. Basic Clin Pharmacol Toxicol. 2008 Aug;103(2):157-65.
387 Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo. J Asian Nat Prod Res. 2012;14(4):382-95.
388 Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.
389 Stiripentol. Expert Opin Investig Drugs. 2005 Jul;14(7):905-11.
390 Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):843-52.
391 Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor. Drug Metab Dispos. 2003 Nov;31(11):1352-60.
392 Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. J Med Chem. 2005 Jun 2;48(11):3808-15.
393 Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
394 Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
395 Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
396 Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
397 Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
398 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
399 -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
400 Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
401 Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. J Toxicol Sci. 2015 Jun;40(3):329-38. doi: 10.2131/jts.40.329.
402 Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Implication for its cardiac developmental toxicity. Toxicology. 2020 Apr 15;435:152422. doi: 10.1016/j.tox.2020.152422. Epub 2020 Feb 26.
403 Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. Bioorg Med Chem. 2007 Jul 15;15(14):4863-75. doi: 10.1016/j.bmc.2007.04.057. Epub 2007 May 3.
404 Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochem Pharmacol. 2011 Feb 15;81(4):510-7. doi: 10.1016/j.bcp.2010.11.014. Epub 2010 Nov 27.
405 Actinomycin D inhibits the expression of the cystine/glutamate transporter xCT via attenuation of CD133 synthesis in CD133(+) HCC. Chem Biol Interact. 2019 Aug 25;309:108713. doi: 10.1016/j.cbi.2019.06.026. Epub 2019 Jun 19.
406 Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells. Ann Hematol. 2010 Nov;89(11):1115-24. doi: 10.1007/s00277-010-0988-z. Epub 2010 May 25.
407 The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
408 The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. DNA Repair (Amst). 2004 Mar 4;3(3):235-44. doi: 10.1016/j.dnarep.2003.10.014.
409 Curcumin inhibits hypoxia-inducible factor-1 by degrading aryl hydrocarbon receptor nuclear translocator: a mechanism of tumor growth inhibition. Mol Pharmacol. 2006 Nov;70(5):1664-71. doi: 10.1124/mol.106.025817. Epub 2006 Jul 31.
410 Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2. Toxicol In Vitro. 2011 Apr;25(3):671-83.
411 Omeprazole inhibits pancreatic cancer cell invasion through a nongenomic aryl hydrocarbon receptor pathway. Chem Res Toxicol. 2015 May 18;28(5):907-18.
412 Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
413 [Mechanisms underlying the effect of arsenic trioxide on proliferation inhibition and apoptosis induction in myeloma cell line u266]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Oct;15(5):982-5.
414 Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
415 Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
416 Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
417 Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
418 Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
419 mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
420 Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
421 Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1. Mol Endocrinol. 2010 May;24(5):969-80. doi: 10.1210/me.2009-0148. Epub 2010 Mar 8.
422 Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013 Apr 25;203(2):412-22. doi: 10.1016/j.cbi.2013.03.011. Epub 2013 Mar 22.
423 Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
424 K-RAS transformation in prostate epithelial cell overcomes H2O2-induced apoptosis via upregulation of gamma-glutamyltransferase-2. Toxicol In Vitro. 2012 Apr;26(3):429-34. doi: 10.1016/j.tiv.2012.01.013. Epub 2012 Jan 17.
425 Nitric oxide inhibits execution of apoptosis at two distinct ATP-dependent steps upstream and downstream of mitochondrial cytochrome c release. Biochem Biophys Res Commun. 1999 Apr 29;258(1):215-21. doi: 10.1006/bbrc.1999.0491.
426 Troglitazone induces cytotoxicity in part by promoting the degradation of peroxisome proliferator-activated receptor co-activator-1 protein. Br J Pharmacol. 2010 Oct;161(4):771-81. doi: 10.1111/j.1476-5381.2010.00900.x.
427 Under ambient UVA exposure, pefloxacin exhibits both immunomodulatory and genotoxic effects via multiple mechanisms. J Photochem Photobiol B. 2018 Jan;178:593-605. doi: 10.1016/j.jphotobiol.2017.12.014. Epub 2017 Dec 15.
428 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
429 Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.
430 Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
431 Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
432 Protective role of HO-1 for alcohol-dependent liver damage. Dig Dis. 2010;28(6):792-8. doi: 10.1159/000324287. Epub 2011 Apr 27.
433 Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease. J Neurosci. 2016 Jun 8;36(23):6332-51. doi: 10.1523/JNEUROSCI.0426-16.2016.
434 Simvastatin protects dopaminergic neurons against MPP+-induced oxidative stress and regulates the endogenous anti-oxidant system through ERK. Cell Physiol Biochem. 2018;51(4):1957-1968.
435 P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
436 P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation. Food Chem Toxicol. 2016 Feb;88:1-12. doi: 10.1016/j.fct.2015.12.004. Epub 2015 Dec 11.
437 Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20;2:55. doi: 10.1186/1755-8794-2-55.
438 Effects of paclitaxel on proliferation and apoptosis in human acute myeloid leukemia HL-60 cells. Acta Pharmacol Sin. 2004 Mar;25(3):378-84.
439 Analysis of nucleotide insertion opposite 2,2,4-triamino-5(2H)-oxazolone by eukaryotic B- and Y-family DNA polymerases. Chem Res Toxicol. 2015 Jun 15;28(6):1307-16. doi: 10.1021/acs.chemrestox.5b00114. Epub 2015 Jun 3.
440 Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity. Chem Res Toxicol. 2013 Feb 18;26(2):221-32. doi: 10.1021/tx300392m. Epub 2013 Jan 31.