Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6IR3P)

Drug Name
Liothyronine Drug Info
Synonyms
liothyronine; 3,3',5-Triiodo-L-thyronine; 6893/2/3; Liothyronin; Tresitope; 3,5,3'-triiodothyronine; L-Liothyronine; O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine; triothyrone; Liothyroninum; Liotironina; 3,5,3'-Triiodo-L-thyronine; L-T3; T3; 3,3',5-Triiodothyronine; Triiodo-L-thyronine; Lyothyronine; 3,5,3'TRIIODOTHYRONINE; L-3,5,3'-Triiodothyronine; (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid; T3 (amino acid); T3 (Hormone); L-3,3',5-TriioDOThyronine; Liothyronine [INN:BAN]; Rathyronine; Triothyrone; THYROID HORMONE; Liothyronine I 131; Liothyronine I 131 [USAN]; T3 liothyronine; Cytomel (TN); Euthroid-1; Euthroid-2; Euthroid-3; Liothyronine (INN); Liothyroninum[INN-Latin]; Liotironina [INN-Spanish]; T3 (Triiodothyronine); T3 (VAN); Tertroxin (TN); Thyrolar-1; Thyrolar-2; Thyrolar-3; Tri-Thyrotope; Triiodothyronine (T3); Triomet-131; Euthroid-05; Thyrolar-025; Thyrolar-05; TRIIODOTHYRONINE (T3 OR LIOTHYRONINE, ACTIVE) (6-11%); Thyronine, 3,3',5-triiodo-, L-(6CI); L-3-(4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl)alanine; L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-(9CI); 3,3'5-Triiodo-L-thyronine; 3,5,3'-Tri-iodo-L-thyronine; 4-(3-Iodo-4-hydroxyphenoxy)-3,5-diiodophenylalanine; 4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenylalanine; 4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine
Indication
Disease Entry ICD 11 Status REF
Congenital hypothyroidism Approved [1]
Edema MG29 Approved [1]
Goiter Approved [1]
Hypothyroidism 5A00 Approved [2]
Thyroid cancer 2D10 Approved [1]
Congestive heart failure BD10 Phase 3 [3]
Therapeutic Class
Hormone Replacement Agents
Cross-matching ID
PubChem CID
5920
ChEBI ID
CHEBI:18258
CAS Number
CAS 15785-49-6
TTD Drug ID
DM6IR3P
VARIDT Drug ID
DR00173
INTEDE Drug ID
DR0959
ACDINA Drug ID
D00368

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Patented Agent(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Thyroid hormone receptor alpha (THRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levothyroxine DMHN027 Congenital hypothyroidism Approved [17]
Dextrothyroxine Sodium DMBVEC7 High blood cholesterol level 5C80.00 Approved [18]
BCT303 DMUFY4K Hypothyroidism 5A00 Phase 2 [19]
tiratricol DMZO6CV Wound healing EL8Y Clinical trial [20]
3-(dibutylamino)-1-(4-hexylphenyl)propan-1-one DM2JBQI Discovery agent N.A. Investigative [21]
3-(3,5-Dibromo-4-hexyloxy-phenyl)-propionic acid DMDFHCU Discovery agent N.A. Investigative [22]
3-(dimethylamino)-1-(4-hexylphenyl)propan-1-one DMJYCHG Discovery agent N.A. Investigative [21]
4-(4-hexylphenyl)-4-oxobut-2-enoic acid DMR9TBW Discovery agent N.A. Investigative [21]
(3,5-Dibromo-4-hexyloxy-phenyl)-acetic acid DM5GN46 Discovery agent N.A. Investigative [22]
1-(4-hexylphenyl)-3-morpholinopropan-1-one DMFN8T6 Discovery agent N.A. Investigative [21]
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Drug(s) Transported By Organic anion transporting polypeptide 1B1 (SLCO1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [23]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [24]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [25]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [26]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [25]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [27]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [28]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [29]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [30]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [27]
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Drug(s) Transported By Sodium/taurocholate cotransporting polypeptide (SLC10A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [31]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [32]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [33]
Estrone sulfate DMVBIZL Atrophic vaginitis GA30.2 Approved [34]
Taurocholic Acid DM2LZ8F Type-2 diabetes 5A11 Phase 1/2 [35]
Sodium taurocholate DM3GO0J Type-2 diabetes 5A11 Phase 1/2 [36]
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Drug(s) Transported By Organic anion transporting polypeptide 1A2 (SLCO1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [37]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [38]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [39]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [40]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [32]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [33]
Saquinavir DMG814N Human immunodeficiency virus infection 1C62 Approved [41]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [42]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [43]
Labetalol DMK8U72 Hypertension BA00-BA04 Approved [44]
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Drug(s) Transported By Organic anion transporting polypeptide 1B3 (SLCO1B3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [10]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [25]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [45]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [46]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [25]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [47]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [28]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [30]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [48]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [30]
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Drug(s) Transported By Organic anion transporting polypeptide 1C1 (SLCO1C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [49]
Levothyroxine DMHN027 Congenital hypothyroidism Approved [49]
[3H]estradiol-17beta-glucuronide DM3KJ45 Discovery agent N.A. Investigative [50]
Drug(s) Transported By Organic anion transporting polypeptide 4A1 (SLCO4A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [51]
Estrone sulfate DMVBIZL Atrophic vaginitis GA30.2 Approved [52]
Benzylpenicillin DMS9503 Actinomycosis Phase 3 [51]
Taurocholic Acid DM2LZ8F Type-2 diabetes 5A11 Phase 1/2 [8]
Drug(s) Transported By Organic anion transporting polypeptide 4C1 (SLCO4C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Digoxin DMQCTIH Arrhythmia BC9Z Approved [6]
Saxagliptin DMGXENV Type-2 diabetes 5A11 Approved [53]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [6]
Estrone sulfate DMVBIZL Atrophic vaginitis GA30.2 Approved [54]
Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [55]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [56]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [57]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [58]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [61]
Metronidazole DMTIVEN Abscess Approved [62]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [63]
Ethanol DMDRQZU Chronic pain MG30 Approved [64]
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Drug(s) Metabolized By Sulfotransferase 1A1 (SULT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [65]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [66]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [67]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [68]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [69]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [70]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [71]
Epinephrine DM3KJBC Acute asthma CA23 Approved [72]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [73]
Teicoplanin DMAQ2LK Bacterial infection 1A00-1C4Z Approved [74]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [75]
Minoxidil DMA2Z4F Alopecia ED70 Approved [76]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [73]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [76]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [69]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
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Drug(s) Affected By Monocarboxylate transporter 4 (SLC16A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [84]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [85]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [88]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [89]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
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Drug(s) Affected By All-trans-retinol dehydrogenase ADH1B (ADH1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [91]
Selenium DM25CGV N. A. N. A. Approved [92]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [93]
Leflunomide DMR8ONJ Arthritis FA20 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [95]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [96]
Flucloxacillin DMNUWST Bacterial infection 1A00-1C4Z Approved [97]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [86]
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Drug(s) Affected By Alpha-enolase (ENO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [98]
Etretinate DM2CZFA Keratosis ED56 Approved [99]
Methotrexate DM2TEOL Anterior urethra cancer Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [101]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [102]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [104]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [105]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [106]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [107]
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Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [108]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [109]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [110]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [111]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [112]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [112]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [114]
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Drug(s) Affected By Collagen alpha-3(VI) chain (COL6A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Panobinostat DM58WKG Chronic graft versus host disease Approved [116]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [114]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [117]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [89]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [96]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [118]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [119]
Arsenic DMTL2Y1 N. A. N. A. Approved [120]
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Drug(s) Affected By Ras-related protein Rab-3B (RAB3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [121]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [88]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [89]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [123]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [124]
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Drug(s) Affected By Fibroblast growth factor 7 (FGF7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [125]
Methotrexate DM2TEOL Anterior urethra cancer Approved [126]
Quercetin DM3NC4M Obesity 5B81 Approved [127]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [114]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [128]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [126]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [129]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [119]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [130]
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Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [131]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [132]
Diazepam DM08E9O Alcohol withdrawal Approved [133]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [134]
Desogestrel DM27U4Y Contraception QA21 Approved [134]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [132]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [132]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [135]
Quercetin DM3NC4M Obesity 5B81 Approved [136]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
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Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [132]
Diazepam DM08E9O Alcohol withdrawal Approved [133]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [137]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [138]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [132]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [139]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [132]
Testosterone DM7HUNW Hot flushes GA30 Approved [140]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [141]
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Drug(s) Affected By ATP-dependent 6-phosphofructokinase, platelet type (PFKP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [142]
Quercetin DM3NC4M Obesity 5B81 Approved [143]
Panobinostat DM58WKG Chronic graft versus host disease Approved [116]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [144]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [88]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [145]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [131]
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Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [146]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [132]
Diazepam DM08E9O Alcohol withdrawal Approved [133]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [147]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [132]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [132]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [148]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [141]
Ethacrynic acid DM60QMR Edema MG29 Approved [147]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [132]
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Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [149]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Prednisone DM2HG4X Acute asthma CA23 Approved [151]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [151]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [152]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [153]
Epinephrine DM3KJBC Acute asthma CA23 Approved [154]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Fluoxetine DM3PD2C Bipolar depression Approved [155]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [156]
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Drug(s) Affected By Superoxide dismutase (SOD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [157]
Haloperidol DM96SE0 Delirium Approved [158]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [159]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [160]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [162]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [163]
Methotrexate DM2TEOL Anterior urethra cancer Approved [164]
Epinephrine DM3KJBC Acute asthma CA23 Approved [165]
Quercetin DM3NC4M Obesity 5B81 Approved [166]
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Drug(s) Affected By Monocarboxylate transporter 7 (SLC16A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [167]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [84]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [104]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [121]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [106]
Leflunomide DMR8ONJ Arthritis FA20 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [169]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [170]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [171]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [172]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [173]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [173]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [174]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [175]
Capsaicin DMGMF6V Back pain ME84.Z Approved [176]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [177]
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Drug(s) Affected By Stromelysin-3 (MMP11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [178]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [180]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [181]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [182]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [145]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Methotrexate DM2TEOL Anterior urethra cancer Approved [183]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [102]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [184]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [185]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [186]
Leflunomide DMR8ONJ Arthritis FA20 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glucose-6-phosphatase catalytic subunit 1 (G6PC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Fluoxetine DM3PD2C Bipolar depression Approved [187]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [93]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [185]
Leflunomide DMR8ONJ Arthritis FA20 Approved [188]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [93]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [93]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [95]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [189]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [190]
Calcidiol DMN4CV5 Hypophosphatemia Approved [191]
Calcipotriol DM03CP7 Psoriasis EA90 Approved [192]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [193]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [194]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [195]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [196]
Testosterone DM7HUNW Hot flushes GA30 Approved [197]
Leflunomide DMR8ONJ Arthritis FA20 Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Organic solute transporter subunit beta (SLC51B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [198]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [199]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [102]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [200]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [201]
Leflunomide DMR8ONJ Arthritis FA20 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcriptional and immune response regulator (TCIM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [202]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [203]
Testosterone DM7HUNW Hot flushes GA30 Approved [197]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [197]
Leflunomide DMR8ONJ Arthritis FA20 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [204]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Folic Acid DMEMBJC Colorectal carcinoma Approved [205]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [206]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [207]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [208]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [209]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [210]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [211]
Ethacrynic acid DM60QMR Edema MG29 Approved [147]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [212]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [213]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [214]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [215]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [215]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [215]
Capsaicin DMGMF6V Back pain ME84.Z Approved [216]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [217]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [218]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [219]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [220]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [221]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [158]
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Drug(s) Affected By Thyroid hormone-inducible hepatic protein (THRSP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [93]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [93]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [93]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [222]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [222]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [86]
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Drug(s) Affected By Uncharacterized protein C20orf204 (C20ORF204)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [224]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [225]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [86]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [86]
Drug(s) Affected By Meiosis-specific coiled-coil domain-containing protein MEIOC (MEIOC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [226]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [116]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [227]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [228]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [229]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [116]
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Drug(s) Affected By LYR motif-containing protein 9 (LYRM9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [180]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [225]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [145]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [131]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [230]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [231]
GSK2110183 DMZHB37 leukaemia 2A60-2B33 Phase 2 [232]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [233]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [234]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [137]
Methotrexate DM2TEOL Anterior urethra cancer Approved [235]
Quercetin DM3NC4M Obesity 5B81 Approved [236]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [237]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [238]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [239]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [240]
Olaparib DM8QB1D Ovarian cancer 2C73 Approved [241]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apolipoprotein L1 (APOL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [242]
Selenium DM25CGV N. A. N. A. Approved [92]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Testosterone DM7HUNW Hot flushes GA30 Approved [197]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [197]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Bortezomib DMNO38U Leukemia Approved [243]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [225]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proepiregulin (EREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [234]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [244]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [244]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [244]
Methotrexate DM2TEOL Anterior urethra cancer Approved [245]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [238]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [246]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [244]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine palmitoyltransferase 2 (SPTLC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [159]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [114]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [247]
Testosterone DM7HUNW Hot flushes GA30 Approved [140]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [248]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [88]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [249]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 12 (ADAM12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [127]
Panobinostat DM58WKG Chronic graft versus host disease Approved [116]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Folic Acid DMEMBJC Colorectal carcinoma Approved [205]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [250]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [225]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [251]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [131]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [252]
Chlorothiazide DMLHESP Chronic heart failure BD1Z Approved [253]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytoplasmic dynein 1 light intermediate chain 2 (DYNC1LI2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [224]
Quercetin DM3NC4M Obesity 5B81 Approved [254]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [88]
Clozapine DMFC71L Schizophrenia 6A20 Approved [111]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [82]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [255]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [83]
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Drug(s) Affected By Trans-Golgi network integral membrane protein 2 (TGOLN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [14]
Quercetin DM3NC4M Obesity 5B81 Approved [254]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [114]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Testosterone enanthate DMB6871 N. A. N. A. Approved [256]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [14]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [257]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lysine-specific demethylase hairless (HR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [248]
Leflunomide DMR8ONJ Arthritis FA20 Approved [94]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [180]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [225]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [258]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [259]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [131]
Urethane DM7NSI0 N. A. N. A. Phase 4 [260]
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Drug(s) Affected By Prostate stem cell antigen (PSCA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Quercetin DM3NC4M Obesity 5B81 Approved [261]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [225]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [75]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [262]
ACYLINE DM9GRTK Prostate cancer 2C82.0 Phase 2 [263]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [264]
Flavonoid derivative 1 DMCQP0B N. A. N. A. Patented [261]
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Drug(s) Affected By Plexin-C1 (PLXNC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Panobinostat DM58WKG Chronic graft versus host disease Approved [116]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [203]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [265]
Leflunomide DMR8ONJ Arthritis FA20 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [266]
Arsenic DMTL2Y1 N. A. N. A. Approved [120]
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Drug(s) Affected By TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (TAF5L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [92]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [227]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [267]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [268]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [269]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [131]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [270]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [271]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [272]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [272]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [95]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [271]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [272]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [273]
Gefitinib DM15F0X Colon adenocarcinoma Approved [271]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [274]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [271]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Echinoderm microtubule-associated protein-like 2 (EML2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [92]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [144]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [88]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [180]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [225]
Arsenic DMTL2Y1 N. A. N. A. Approved [275]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [131]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [92]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Low-density lipoprotein receptor (LDLR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [276]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [137]
Desogestrel DM27U4Y Contraception QA21 Approved [276]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [277]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [278]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [102]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [93]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [279]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-1 alpha (IL1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [242]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [244]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [244]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [280]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [244]
Methotrexate DM2TEOL Anterior urethra cancer Approved [183]
Quercetin DM3NC4M Obesity 5B81 Approved [236]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [244]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [211]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [281]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [282]
Gefitinib DM15F0X Colon adenocarcinoma Approved [283]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [244]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [244]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [284]
Selenium DM25CGV N. A. N. A. Approved [285]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [286]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [287]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [158]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [288]
Diazepam DM08E9O Alcohol withdrawal Approved [289]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [290]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [291]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [292]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [293]
Methotrexate DM2TEOL Anterior urethra cancer Approved [294]
Quercetin DM3NC4M Obesity 5B81 Approved [295]
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Drug(s) Affected By Estrogen receptor (ESR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [296]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [297]
Gefitinib DM15F0X Colon adenocarcinoma Approved [298]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [299]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [300]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [301]
Quercetin DM3NC4M Obesity 5B81 Approved [302]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [303]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [299]
Estrone DM5T6US Acne vulgaris ED80 Approved [304]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Antileukoproteinase (SLPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [244]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [244]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [244]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [244]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [244]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [244]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [244]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [244]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amyloid-beta precursor protein (APP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [178]
Selenium DM25CGV N. A. N. A. Approved [92]
Methotrexate DM2TEOL Anterior urethra cancer Approved [183]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [305]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [238]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [306]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [307]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [308]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [114]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [309]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thyroxine-binding globulin (SERPINA7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leuprolide DM5XPIJ Plasma cell myeloma 2A83.1 Approved [158]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [310]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [311]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [75]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [86]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [312]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salmeterol DMIEU69 Allergic asthma CA23.0 Approved [313]
Bambuterol DMKLSHF Asthma CA23 Approved [314]
Terbutaline DMD4381 Asthma CA23 Approved [315]
Salbutamol DMN9CWF Acute asthma CA23 Approved [316]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [317]
Methotrexate DM2TEOL Anterior urethra cancer Approved [224]
Epinephrine DM3KJBC Acute asthma CA23 Approved [318]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [319]
Propranolol DM79NTF Angina pectoris BA40 Approved [320]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [126]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [121]
Testosterone DM7HUNW Hot flushes GA30 Approved [321]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [322]
Leflunomide DMR8ONJ Arthritis FA20 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [323]
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Drug(s) Affected By Histone H2A type 1 (H2AC11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [242]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [324]
Testosterone DM7HUNW Hot flushes GA30 Approved [197]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [197]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [267]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [268]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [225]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [325]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [326]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [327]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [198]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [328]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [282]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [244]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [329]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [244]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [330]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [331]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [332]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [333]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [158]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [242]
Verapamil DMA7PEW Angina pectoris BA40 Approved [334]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [335]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [336]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [337]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thyroid hormone receptor beta (THRB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [338]
Panobinostat DM58WKG Chronic graft versus host disease Approved [116]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [339]
Testosterone DM7HUNW Hot flushes GA30 Approved [140]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [248]
Leflunomide DMR8ONJ Arthritis FA20 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Ethanol DMDRQZU Chronic pain MG30 Approved [340]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [341]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [242]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [342]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Selenium DM25CGV N. A. N. A. Approved [343]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [291]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [344]
Meloxicam DM2AR7L Arthritis FA20 Approved [345]
Methotrexate DM2TEOL Anterior urethra cancer Approved [245]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [148]
Epinephrine DM3KJBC Acute asthma CA23 Approved [154]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 5 (CCL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [160]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [346]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [347]
Methotrexate DM2TEOL Anterior urethra cancer Approved [183]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [348]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [238]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [350]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [351]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Replication protein A 32 kDa subunit (RPA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [234]
Etretinate DM2CZFA Keratosis ED56 Approved [352]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [238]
Testosterone DM7HUNW Hot flushes GA30 Approved [197]
Quizartinib DM8Y4JS Acute myeloid leukaemia 2A60 Approved [353]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [197]
Leflunomide DMR8ONJ Arthritis FA20 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [88]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [354]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [355]
Selenium DM25CGV N. A. N. A. Approved [92]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [356]
Etretinate DM2CZFA Keratosis ED56 Approved [352]
Methotrexate DM2TEOL Anterior urethra cancer Approved [357]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [358]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [359]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [360]
Quercetin DM3NC4M Obesity 5B81 Approved [361]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H1.5 (H1-5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [242]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [362]
Methotrexate DM2TEOL Anterior urethra cancer Approved [363]
Quercetin DM3NC4M Obesity 5B81 Approved [364]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [324]
Testosterone DM7HUNW Hot flushes GA30 Approved [197]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [197]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [365]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neuroendocrine convertase 2 (PCSK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [366]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [367]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [252]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [228]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [229]
4-hydroxy-2-nonenal DM2LJFZ Discovery agent N.A. Investigative [178]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [142]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Integrin beta-5 (ITGB5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [178]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [14]
Panobinostat DM58WKG Chronic graft versus host disease Approved [116]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [14]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [116]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [88]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [368]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [14]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [369]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-A2 (CCNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [370]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [371]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [342]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [137]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [344]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [372]
Methotrexate DM2TEOL Anterior urethra cancer Approved [363]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [148]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [373]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [374]
Verapamil DMA7PEW Angina pectoris BA40 Approved [375]
Methysergide DM1EF73 Migraine 8A80 Approved [273]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [376]
Methotrexate DM2TEOL Anterior urethra cancer Approved [224]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [273]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [102]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [377]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [378]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bone morphogenetic protein 6 (BMP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [244]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [244]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [379]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [244]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [244]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [244]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [244]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [244]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [248]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [117]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-32 (IL32)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [183]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [380]
Testosterone DM7HUNW Hot flushes GA30 Approved [197]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [197]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [368]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [369]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [369]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [381]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [382]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [337]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [297]
Gefitinib DM15F0X Colon adenocarcinoma Approved [383]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [384]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [385]
Selenium DM25CGV N. A. N. A. Approved [92]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [386]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [387]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [242]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [388]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [344]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [389]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [372]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Fluoxetine DM3PD2C Bipolar depression Approved [390]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [391]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [392]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [393]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neuroendocrine convertase 1 (PCSK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [139]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [167]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [89]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [394]
Gatifloxacin DMSL679 Acute gonococcal cervicitis Approved [395]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [396]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [131]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [397]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [398]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [399]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [400]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [337]
Gefitinib DM15F0X Colon adenocarcinoma Approved [401]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [402]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [403]
Selenium DM25CGV N. A. N. A. Approved [92]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [291]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [386]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [404]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [85]
Leflunomide DMR8ONJ Arthritis FA20 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [88]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [405]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [406]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [407]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [408]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [409]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [410]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [411]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [412]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [202]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [244]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [413]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Beta-adducin (ADD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [88]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [131]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [414]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [415]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [416]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [417]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [125]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [160]
Gefitinib DM15F0X Colon adenocarcinoma Approved [418]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [384]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [137]
Etretinate DM2CZFA Keratosis ED56 Approved [419]
Prednisone DM2HG4X Acute asthma CA23 Approved [420]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [389]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [421]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [422]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [423]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [424]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [425]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [426]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [427]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [428]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [429]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [430]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [431]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier family 15 member 1 (SLC15A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [200]
Repaglinide DM5SXUV Diabetic complication 5A2Y Approved [432]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [203]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [433]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [227]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [368]
Benzoic Acid DMKB9FI Alopecia areata ED70.2 Approved [433]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [434]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [435]
Gefitinib DM15F0X Colon adenocarcinoma Approved [383]
Prednisone DM2HG4X Acute asthma CA23 Approved [420]
Methotrexate DM2TEOL Anterior urethra cancer Approved [436]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [437]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [300]
Quercetin DM3NC4M Obesity 5B81 Approved [438]
Fluoxetine DM3PD2C Bipolar depression Approved [390]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [439]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [440]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Inactive serine/threonine-protein kinase 19 (STK19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [441]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [89]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [229]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [442]
Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [443]
Methotrexate DM2TEOL Anterior urethra cancer Approved [183]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [102]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [377]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [444]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [105]
Leflunomide DMR8ONJ Arthritis FA20 Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxisomal targeting signal 1 receptor (PEX5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic DMTL2Y1 N. A. N. A. Approved [120]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [75]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [259]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [92]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [445]
Drug(s) Affected By Protein HIRA (HIRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [268]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [446]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [83]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [228]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [447]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [254]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMGCS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [448]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [93]
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [449]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [82]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [75]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [86]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [450]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [451]
Urethane DM7NSI0 N. A. N. A. Phase 4 [260]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thyroxine 5-deiodinase (DIO3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [452]
Vemurafenib DM62UG5 Melanoma 2C30 Approved [453]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Ergocalciferol DMHO0AR Hypoparathyroidism 5A50 Approved [454]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [452]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [454]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [452]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [455]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [452]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [456]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By A-kinase anchor protein 12 (AKAP12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [193]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [93]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [194]
Panobinostat DM58WKG Chronic graft versus host disease Approved [116]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [457]
Testosterone DM7HUNW Hot flushes GA30 Approved [197]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [248]
Leflunomide DMR8ONJ Arthritis FA20 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 2 (DUSP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Methotrexate DM2TEOL Anterior urethra cancer Approved [183]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [114]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [458]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [267]
Epanova DMHEAGL Hypertriglyceridemia 5C80.1 Approved [459]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [266]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [460]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 9 (TNFRSF9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [159]
Methotrexate DM2TEOL Anterior urethra cancer Approved [183]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [461]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [462]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [267]
Menthol DMG2KW7 Back pain ME84.Z Approved [463]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [464]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [89]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [330]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [431]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [242]
Verapamil DMA7PEW Angina pectoris BA40 Approved [334]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [159]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [465]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [384]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [178]
Meloxicam DM2AR7L Arthritis FA20 Approved [345]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [389]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [400]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [466]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [467]
Selenium DM25CGV N. A. N. A. Approved [92]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [468]
Methotrexate DM2TEOL Anterior urethra cancer Approved [245]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [469]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [470]
Quercetin DM3NC4M Obesity 5B81 Approved [236]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [211]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-24 (IL24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [242]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [244]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [282]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [244]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [244]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [471]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [238]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [472]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [244]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [472]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pregnancy-specific beta-1-glycoprotein 7 (PSG7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lucanthone DMZLBUO Solid tumour/cancer 2A00-2F9Z Approved [473]
Seocalcitol DMKL9QO Rickets 5B57 Phase 3 [322]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [229]
Milchsaure DM462BT Pruritus EC90 Investigative [474]
Drug(s) Affected By TNF receptor-associated factor 1 (TRAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [475]
Methotrexate DM2TEOL Anterior urethra cancer Approved [363]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [114]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [265]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [267]
Folic Acid DMEMBJC Colorectal carcinoma Approved [476]
Menthol DMG2KW7 Back pain ME84.Z Approved [463]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [477]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [89]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [258]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [478]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [131]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [479]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [252]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [478]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Krueppel-like factor 9 (KLF9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [480]
Selenium DM25CGV N. A. N. A. Approved [92]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [14]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [481]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [14]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [339]
Leflunomide DMR8ONJ Arthritis FA20 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutamate receptor ionotropic, kainate 4 (GRIK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [142]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [114]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [482]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [483]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [142]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By kinase isozyme 4, mitochondrial (PDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [127]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [484]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [485]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [106]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [106]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [106]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Testosterone enanthate DMB6871 N. A. N. A. Approved [256]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [93]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tigger transposable element-derived protein 6 (TIGD6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [85]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [268]
Urethane DM7NSI0 N. A. N. A. Phase 4 [260]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [486]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [487]
Drug(s) Affected By Transmembrane protein 44 (TMEM44)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [89]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [96]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [369]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [369]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [86]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [228]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [483]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [415]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Akirin-2 (AKIRIN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Testosterone DM7HUNW Hot flushes GA30 Approved [140]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [79]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [243]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [89]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [405]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein FAM171B (FAM171B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [368]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [225]
Arsenic DMTL2Y1 N. A. N. A. Approved [120]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [145]
Urethane DM7NSI0 N. A. N. A. Phase 4 [260]
OTX-015 DMI8RG1 Acute myeloid leukaemia 2A60 Phase 1/2 [488]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [397]
Mivebresib DMCPF90 Acute myeloid leukaemia 2A60 Phase 1 [488]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein FAM83H (FAM83H)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Arsenic DMTL2Y1 N. A. N. A. Approved [120]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Urethane DM7NSI0 N. A. N. A. Phase 4 [260]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [229]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [487]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [254]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [254]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [489]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Butyrophilin subfamily 2 member A1 (BTN2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Urethane DM7NSI0 N. A. N. A. Phase 4 [260]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [79]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [267]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Mesoderm induction early response protein 3 (MIER3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [204]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [131]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [229]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [254]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [490]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [416]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Tripartite motif-containing protein 46 (TRIM46)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [258]
GSK2110183 DMZHB37 leukaemia 2A60-2B33 Phase 2 [232]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [491]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [229]
uric acid DMA1MKT Discovery agent N.A. Investigative [492]
Drug(s) Affected By Retrotransposon-derived protein PEG10 (PEG10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [93]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [194]
Testosterone DM7HUNW Hot flushes GA30 Approved [140]
Leflunomide DMR8ONJ Arthritis FA20 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [88]
Ethanol DMDRQZU Chronic pain MG30 Approved [493]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [494]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho guanine nucleotide exchange factor 25 (ARHGEF25)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Arsenic DMTL2Y1 N. A. N. A. Approved [120]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [145]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [131]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [229]
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Drug(s) Affected By Condensin-2 complex subunit G2 (NCAPG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [363]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Testosterone DM7HUNW Hot flushes GA30 Approved [197]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [197]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [495]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [88]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [365]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [311]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Coiled-coil domain-containing protein 71 (CCDC71)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [85]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [131]
Urethane DM7NSI0 N. A. N. A. Phase 4 [260]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [229]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [487]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [254]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [496]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Iron-sulfur cluster co-chaperone protein HscB (HSCB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [266]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [405]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [228]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [86]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [487]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [442]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [267]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Abnormal spindle-like microcephaly-associated protein (ASPM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [363]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [238]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [114]
Testosterone DM7HUNW Hot flushes GA30 Approved [197]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [497]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [197]
Leflunomide DMR8ONJ Arthritis FA20 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By EF-hand calcium-binding domain-containing protein 4A (CRACR2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [167]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [204]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [89]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [225]
Arsenic DMTL2Y1 N. A. N. A. Approved [498]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [131]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [252]
Urethane DM7NSI0 N. A. N. A. Phase 4 [260]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By EF-hand calcium-binding domain-containing protein 3 (EFCAB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [145]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [229]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [499]
Drug(s) Affected By Inactive phospholipase D5 (PLD5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [226]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [368]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [225]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [75]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [86]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [228]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [252]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [116]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Acyl-CoA-binding domain-containing protein 4 (ACBD4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [197]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [197]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [243]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [258]
Urethane DM7NSI0 N. A. N. A. Phase 4 [260]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [229]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [500]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [501]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [431]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [281]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [502]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [503]
Quercetin DM3NC4M Obesity 5B81 Approved [504]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [102]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [505]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [506]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [507]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [88]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [268]
Arsenic DMTL2Y1 N. A. N. A. Approved [508]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [131]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [228]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [229]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [487]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho-related GTP-binding protein RhoV (RHOV)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [242]
Methotrexate DM2TEOL Anterior urethra cancer Approved [245]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [368]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [258]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [252]
Urethane DM7NSI0 N. A. N. A. Phase 4 [260]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [229]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [142]
Milchsaure DM462BT Pruritus EC90 Investigative [474]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Msx2-interacting protein (SPEN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [92]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [339]
Testosterone enanthate DMB6871 N. A. N. A. Approved [256]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [416]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [509]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [405]
Arsenic DMTL2Y1 N. A. N. A. Approved [120]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [145]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [131]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By PTB domain-containing engulfment adapter protein 1 (GULP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [142]
Selenium DM25CGV N. A. N. A. Approved [92]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [14]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [441]
Ethanol DMDRQZU Chronic pain MG30 Approved [510]
Folic Acid DMEMBJC Colorectal carcinoma Approved [205]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [89]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By LIM/homeobox protein Lhx3 (LHX3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [159]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [243]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [225]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [511]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [512]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Protein mono-ADP-ribosyltransferase PARP4 (PARP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Leflunomide DMR8ONJ Arthritis FA20 Approved [94]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [88]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [513]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [131]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [514]
Lithium DMZ3OU6 Bipolar disorder 6A60 Phase 2 [515]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras-related protein Rab-23 (RAB23)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Testosterone DM7HUNW Hot flushes GA30 Approved [197]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [197]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [243]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [369]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [405]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [75]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [516]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [244]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [480]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [244]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [244]
Methotrexate DM2TEOL Anterior urethra cancer Approved [126]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [358]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Fluoxetine DM3PD2C Bipolar depression Approved [517]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [244]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sulfotransferase 4A1 (SULT4A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic DMTL2Y1 N. A. N. A. Approved [498]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [252]
Estrone DM5T6US Acne vulgaris ED80 Approved [518]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [519]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [229]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [487]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [416]
Mononitrophenol DM4QO9G N. A. N. A. Investigative [518]
L-thyroxine DM83HWL N. A. N. A. Investigative [518]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Thyrotropin subunit beta (TSHB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [520]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Octreotide DMHIDCJ Acromegaly 5A60.0 Approved [521]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [522]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [523]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [524]
NITRATE DMVFB93 Discovery agent N.A. Investigative [525]
[3H]cAMP DMZRQU7 Discovery agent N.A. Investigative [526]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Type I iodothyronine deiodinase (DIO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [527]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [528]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [227]
Ergocalciferol DMHO0AR Hypoparathyroidism 5A50 Approved [454]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [338]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [454]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [311]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [529]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Monocarboxylate transporter 8 (SLC16A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [84]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [85]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [180]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [131]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [312]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [479]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [530]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Thyroid hormone receptor alpha (THRA) TTTSEPU THA_HUMAN Antagonist [4]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic anion transporting polypeptide 1C1 (SLCO1C1) DTPYCQ4 SO1C1_HUMAN Substrate [5]
Organic anion transporting polypeptide 4A1 (SLCO4A1) DT8H2IC SO4A1_HUMAN Substrate [6]
Organic anion transporting polypeptide 4C1 (SLCO4C1) DTY0QMU SO4C1_HUMAN Substrate [6]
Sodium/taurocholate cotransporting polypeptide (SLC10A1) DT56EKP NTCP_HUMAN Substrate [7]
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [8]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [9]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [10]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [11]
Sulfotransferase 1A1 (SULT1A1) DEYWLRK ST1A1_HUMAN Substrate [12]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1) OTG2T749 CP24A_HUMAN Gene/Protein Processing [13]
A-kinase anchor protein 12 (AKAP12) OTCVRDDX AKA12_HUMAN Gene/Protein Processing [14]
Abnormal spindle-like microcephaly-associated protein (ASPM) OTKXQMNA ASPM_HUMAN Gene/Protein Processing [14]
Acyl-CoA-binding domain-containing protein 4 (ACBD4) OTVR7MLK ACBD4_HUMAN Gene/Protein Processing [14]
Akirin-2 (AKIRIN2) OTQ6WSKW AKIR2_HUMAN Gene/Protein Processing [14]
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [15]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Gene/Protein Processing [16]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Gene/Protein Processing [16]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Gene/Protein Processing [16]
All-trans-retinol dehydrogenase ADH1B (ADH1B) OTV3TB81 ADH1B_HUMAN Gene/Protein Processing [16]

References

1 Liothyronine FDA Label
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 ClinicalTrials.gov (NCT00790738) Liothyronine (T3) for Bipolar Depression. U.S. National Institutes of Health.
4 Evaluation of thyroid hormone action in a case of generalized resistance to thyroid hormone with chronic thyroiditis: discovery of a novel heterozy... Endocr J. 2007 Dec;54(5):727-32.
5 Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier. Endocrinology. 2004 Sep;145(9):4384-91.
6 Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74.
7 Identification of thyroid hormone transporters. Biochem Biophys Res Commun. 1999 Jan 19;254(2):497-501.
8 Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology. 2001 May;142(5):2005-12.
9 Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem. 1999 Jun 11;274(24):17159-63.
10 LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology. 2001 Jun;120(7):1689-99.
11 FDA Label of Liothyronine sodium. The 2020 official website of the U.S. Food and Drug Administration.
12 Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate. J Endocrinol. 2001 Dec;171(3):525-32.
13 Similarities and differences between two modes of antagonism of the thyroid hormone receptor. ACS Chem Biol. 2011 Oct 21;6(10):1096-106.
14 Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
15 In vitro fluorescence displacement investigation of thyroxine transport disruption by bisphenol A. J Environ Sci (China). 2011;23(2):315-21. doi: 10.1016/s1001-0742(10)60408-1.
16 Thyroid hormone responsive genes in cultured human fibroblasts. J Clin Endocrinol Metab. 2005 Feb;90(2):936-43.
17 Thyroid hormone resistance and pituitary enlargement after thyroid ablation in a woman on levothyroxine treatment. Thyroid. 2008 Oct;18(10):1119-23.
18 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
19 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
20 Binding of 3,5,3'-triiodothyronine (T3) and its analogs to the in vitro translational products of c-erbA protooncogenes: differences in the affinity of the alpha- and beta-forms for the acetic acid analog and failure of the human testis and kidney alpha-2 products to bind T3. Mol Endocrinol. 1990 Feb;4(2):227-34.
21 Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80.
22 Thyroid receptor ligands. 3. Design and synthesis of 3,5-dihalo-4-alkoxyphenylalkanoic acids as indirect antagonists of the thyroid hormone receptor. J Med Chem. 2005 May 5;48(9):3114-7.
23 Preclinical Mouse Models To Study Human OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions in Vivo. Mol Pharm. 2015 Dec 7;12(12):4259-69.
24 Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81.
25 Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66.
26 Identification of drugs and drug metabolites as substrates of multidrug resistance protein 2 (MRP2) using triple-transfected MDCK-OATP1B1-UGT1A1-MRP2 cells. Br J Pharmacol. 2012 Mar;165(6):1836-1847.
27 The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15. Pharmacogenet Genomics. 2008 May;18(5):424-33.
28 Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. Eur J Clin Pharmacol. 2007 Dec;63(12):1161-9.
29 Rifampicin alters atorvastatin plasma concentration on the basis of SLCO1B1 521T>C polymorphism. Clin Chim Acta. 2009 Jul;405(1-2):49-52.
30 FDA Drug Development and Drug Interactions
31 Differential effect of genetic variants of Na(+)-taurocholate co-transporting polypeptide (NTCP) and organic anion-transporting polypeptide 1B1 (OATP1B1) on the uptake of HMG-CoA reductase inhibitors. Xenobiotica. 2011 Jan;41(1):24-34.
32 Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase. J Pharm Pharmacol. 2005 Oct;57(10):1305-11.
33 Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Gastroenterology. 2006 May;130(6):1793-806.
34 Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition. J Biol Chem. 2004 Feb 20;279(8):7213-22.
35 Modulation by drugs of human hepatic sodium-dependent bile acid transporter (sodium taurocholate cotransporting polypeptide) activity. J Pharmacol Exp Ther. 1999 Dec;291(3):1204-9.
36 Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity. J Pharmacol Exp Ther. 2007 Jun;321(3):1170-8.
37 Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants. J Pharmacol Exp Ther. 2006 Aug;318(2):521-9.
38 Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3. Pflugers Arch. 2001 Nov;443(2):188-95.
39 Environmental and genetic factors affecting transport of imatinib by OATP1A2. Clin Pharmacol Ther. 2011 Jun;89(6):816-20.
40 Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1. Biochem Pharmacol. 2010 Dec 1;80(11):1746-53.
41 Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells. Mol Pharm. 2004 Jan 12;1(1):49-56.
42 Uptake of enalapril and expression of organic anion transporting polypeptide 1 in zonal, isolated rat hepatocytes. Drug Metab Dispos. 2000 Jul;28(7):801-6.
43 Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology. 1995 Oct;109(4):1274-82.
44 Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol. J Pharm Sci. 2009 Jul;98(7):2529-39.
45 Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol. 2008 Apr 14;584(1):57-65.
46 Influence of non-steroidal anti-inflammatory drugs on organic anion transporting polypeptide (OATP) 1B1- and OATP1B3-mediated drug transport. Drug Metab Dispos. 2011 Jun;39(6):1047-53.
47 Relevance of conserved lysine and arginine residues in transmembrane helices for the transport activity of organic anion transporting polypeptide 1B3. Br J Pharmacol. 2010 Feb 1;159(3):698-708.
48 Impact of OATP transporters on pharmacokinetics. Br J Pharmacol. 2009 Oct;158(3):693-705.
49 Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002 Oct;16(10):2283-96.
50 The blood-brain barrier thyroxine transporter organic anion-transporting polypeptide 1c1 displays atypical transport kinetics. Endocrinology. 2009 Nov;150(11):5153-62.
51 Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60.
52 Involvement of estrone-3-sulfate transporters in proliferation of hormone-dependent breast cancer cells. J Pharmacol Exp Ther. 2004 Dec;311(3):1032-7.
53 Comparative clinical pharmacokinetics of dipeptidyl peptidase-4 inhibitors. Clin Pharmacokinet. 2012 Aug 1;51(8):501-14.
54 Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1: estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C1. Drug Metab Pharmacokinet. 2010;25(3):314-7.
55 Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites. Cancer Res. 2009 Mar 1;69(5):1892-900.
56 Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A1 enzymes. Life Sci. 2010 Aug 14;87(7-8):261-8.
57 Effect of UDP-glucuronosyltransferase (UGT) 1A polymorphism (rs8330 and rs10929303) on glucuronidation status of acetaminophen. Dose Response. 2017 Sep 11;15(3):1559325817723731.
58 UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for etoposide glucuronidation in human liver and intestinal microsomes: structural characterization of phenolic and alcoholic glucuronides of etoposide and estimation of enzyme kinetics. Drug Metab Dispos. 2007 Mar;35(3):371-80.
59 Interindividual variability in pharmacokinetics of generic nucleoside reverse transcriptase inhibitors in TB/HIV-coinfected Ghanaian patients: UGT2B7*1c is associated with faster zidovudine clearance and glucuronidation. J Clin Pharmacol. 2009 Sep;49(9):1079-90.
60 Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10. Drug Metab Dispos. 2009 Jan;37(1):229-36.
61 Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid. Drug Metab Dispos. 2006 Sep;34(9):1632-9.
62 Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8.
63 Substrate-dependent modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1) by propofol in recombinant human UGT1A1 and human liver microsomes. Basic Clin Pharmacol Toxicol. 2007 Sep;101(3):211-4.
64 Identification and preliminary characterization of UDP-glucuronosyltransferases catalyzing formation of ethyl glucuronide. Anal Bioanal Chem. 2014 Apr;406(9-10):2325-32.
65 Progestagenic effects of tibolone are target gene-specific in human endometrial cells. J Soc Gynecol Investig. 2006 Sep;13(6):459-65.
66 Tamoxifen-induced adduct formation and cell stress in human endometrial glands. Drug Metab Dispos. 2010 Jan;38(1):200-7.
67 Proposed role of the sulfotransferase/sulfatase pathway in modulating yolk steroid effects. Integr Comp Biol. 2008 Sep;48(3):419-27.
68 Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects. Birth Defects Res A Clin Mol Teratol. 2008 Mar;82(3):155-65.
69 Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents. Curr Drug Metab. 2006 Oct;7(7):745-53.
70 Natural products isolated from Mexican medicinal plants: novel inhibitors of sulfotransferases, SULT1A1 and SULT2A1. Phytomedicine. 2001 Nov;8(6):481-8.
71 Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1). Xenobiotica. 2010 Mar;40(3):184-94.
72 Crystal structure of human sulfotransferase SULT1A3 in complex with dopamine and 3'-phosphoadenosine 5'-phosphate. Biochem Biophys Res Commun. 2005 Sep 23;335(2):417-23.
73 Sulfation of benzyl alcohol by the human cytosolic sulfotransferases (SULTs): a systematic analysis. J Appl Toxicol. 2016 Sep;36(9):1090-4.
74 The 2.7 A resolution structure of the glycopeptide sulfotransferase Teg14. Acta Crystallogr D Biol Crystallogr. 2010 Dec;66(Pt 12):1278-86.
75 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
76 Enzymatic characterization and interspecies difference of phenol sulfotransferases, ST1A forms. Drug Metab Dispos. 2001 Mar;29(3):274-81.
77 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
78 Methotrexate induction of human sulfotransferases in Hep G2 and Caco-2 cells. J Appl Toxicol. 2005 Sep-Oct;25(5):354-60.
79 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
80 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
81 Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
82 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
83 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
84 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
85 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
86 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
87 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
88 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
89 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
90 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
91 Differences in the activities of resveratrol and ascorbic acid in protection of ethanol-induced oxidative DNA damage in human peripheral lymphocytes. Food Chem Toxicol. 2012 Feb;50(2):168-74.
92 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
93 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
94 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
95 Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
96 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
97 Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury. Toxicol Sci. 2023 Mar 20;192(1):106-116. doi: 10.1093/toxsci/kfad015.
98 Oxidative modifications of proteins by sodium arsenite in human umbilical vein endothelial cells. Environ Toxicol. 2011 Oct;26(5):459-71. doi: 10.1002/tox.20572. Epub 2010 Mar 1.
99 Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
100 Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
101 Differential protein expression of peroxiredoxin I and II by benzo(a)pyrene and quercetin treatment in 22Rv1 and PrEC prostate cell lines. Toxicol Appl Pharmacol. 2007 Apr 15;220(2):197-210. doi: 10.1016/j.taap.2006.12.030. Epub 2007 Jan 9.
102 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
103 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
104 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
105 JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
106 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
107 Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22.
108 Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
109 Insulin regulation of hexose transport in mouse 3T3-L1 cells expressing the human HepG2 glucose transporter. J Biol Chem. 1990 Nov 25;265(33):20106-16.
110 Effects of troglitazone on cellular differentiation, insulin signaling, and glucose metabolism in cultured human skeletal muscle cells. Biochem Biophys Res Commun. 2001 Jan 26;280(3):664-74. doi: 10.1006/bbrc.2000.4216.
111 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
112 Disturbance of cellular glucose transport by two prevalently used fluoroquinolone antibiotics ciprofloxacin and levofloxacin involves glucose transporter type 1. Toxicol Lett. 2009 Jan 30;184(2):81-4. doi: 10.1016/j.toxlet.2008.10.017. Epub 2008 Oct 28.
113 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
114 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
115 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
116 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
117 Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
118 Increased expression of type VI collagen genes in drug-induced gingival enlargement. FEBS Lett. 1993 Nov 8;334(1):65-8. doi: 10.1016/0014-5793(93)81681-o.
119 The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. Hum Reprod. 2010 Nov;25(11):2859-69.
120 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
121 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
122 The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
123 Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
124 Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis. Biol Reprod. 2011 Apr;84(4):801-15.
125 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
126 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
127 Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
128 Regulation of keratinocyte growth factor and scatter factor in cyclosporin-induced gingival overgrowth. J Oral Pathol Med. 2004 Aug;33(7):391-7. doi: 10.1111/j.1600-0714.2004.00223.x.
129 Keratinocyte growth factor is upregulated by the hyperplasia-inducing drug nifedipine. Cytokine. 2000 Oct;12(10):1566-9. doi: 10.1006/cyto.2000.0756.
130 Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21737-42. doi: 10.1073/pnas.1007863107. Epub 2010 Nov 22.
131 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
132 Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. Chem Biol Interact. 2009 Mar 16;178(1-3):221-7.
133 Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines. Biol Pharm Bull. 2002 Apr;25(4):441-5.
134 Progestins as inhibitors of the human 20-ketosteroid reductases, AKR1C1 and AKR1C3. Chem Biol Interact. 2011 May 30;191(1-3):227-33.
135 In-vivo effects of simvastatin and rosuvastatin on global gene expression in peripheral blood leucocytes in a human inflammation model. Pharmacogenet Genomics. 2008 Feb;18(2):109-20.
136 AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids. Chem Biol Interact. 2009 Mar 16;178(1-3):138-44.
137 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
138 A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. Cutan Ocul Toxicol. 2010 Sep;29(3):171-92.
139 Aberrantly expressed genes in HaCaT keratinocytes chronically exposed to arsenic trioxide. Biomark Insights. 2011 Feb 8;6:7-16.
140 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
141 Initro inhibition of AKR1Cs by sulphonylureas and the structural basis. Chem Biol Interact. 2015 Oct 5;240:310-5.
142 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
143 Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
144 Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
145 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
146 Progestin effects on expression of AKR1C1-AKR1C3, SRD5A1 and PGR in the Z-12 endometriotic epithelial cell line. Chem Biol Interact. 2013 Feb 25;202(1-3):218-25.
147 Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 1999 Feb 1;59(3):607-14.
148 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
149 Cannabidiol disrupts apoptosis, autophagy and invasion processes of placental trophoblasts. Arch Toxicol. 2021 Oct;95(10):3393-3406. doi: 10.1007/s00204-021-03122-z. Epub 2021 Jul 24.
150 AMP-activated protein kinase activity is required for vanadate-induced hypoxia-inducible factor 1alpha expression in DU145 cells. Carcinogenesis. 2004 Dec;25(12):2497-507. doi: 10.1093/carcin/bgh253. Epub 2004 Aug 5.
151 Identification of chemical compounds that induce HIF-1alpha activity. Toxicol Sci. 2009 Nov;112(1):153-63.
152 NO-sulindac inhibits the hypoxia response of PC-3 prostate cancer cells via the Akt signalling pathway. Int J Cancer. 2009 Jan 1;124(1):223-32. doi: 10.1002/ijc.23934.
153 Simvastatin stimulates vascular endothelial growth factor production by hypoxia-inducible factor-1alpha upregulation in endothelial cells. J Cardiovasc Pharmacol. 2008 Mar;51(3):267-73. doi: 10.1097/FJC.0b013e3181624b44.
154 Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism. Chem Biol Interact. 2023 Jan 5;369:110278. doi: 10.1016/j.cbi.2022.110278. Epub 2022 Nov 22.
155 Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
156 SU5416 inhibited VEGF and HIF-1alpha expression through the PI3K/AKT/p70S6K1 signaling pathway. Biochem Biophys Res Commun. 2004 Nov 12;324(2):471-80. doi: 10.1016/j.bbrc.2004.09.082.
157 Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity. Anat Cell Biol. 2016 Sep;49(3):165-176. doi: 10.5115/acb.2016.49.3.165. Epub 2016 Sep 29.
158 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
159 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
160 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
161 Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
162 Inactivation of cytochrome c oxidase by mutant SOD1s in mouse motoneuronal NSC-34 cells is independent from copper availability but is because of nitric oxide. J Neurochem. 2010 Jan;112(1):183-92. doi: 10.1111/j.1471-4159.2009.06441.x. Epub 2009 Oct 20.
163 Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen. Brain. 2006 Jul;129(Pt 7):1693-709. doi: 10.1093/brain/awl118. Epub 2006 May 15.
164 Development of an alternative zebrafish model for drug-induced intestinal toxicity. J Appl Toxicol. 2018 Feb;38(2):259-273. doi: 10.1002/jat.3520. Epub 2017 Oct 13.
165 Epinephrine upregulates superoxide dismutase in human coronary artery endothelial cells. Free Radic Biol Med. 2001 Jan 15;30(2):148-53.
166 Molecular pathways in the chemosensitization of cisplatin by quercetin in human head and neck cancer. Cancer Biol Ther. 2005 Sep;4(9):949-55.
167 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
168 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
169 The relative role of CYP3A4 and CYP3A5 in eplerenone metabolism. Toxicol Lett. 2019 Oct 15;315:9-13.
170 Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol. Chem Biol Interact. 2014 May 25;215:62-8.
171 Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells. Toxicol Sci. 2006 Jul;92(1):51-60.
172 The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis. Antimicrob Agents Chemother. 2004 Sep;48(9):3272-8.
173 Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos. 2001 Jan;29(1):30-5.
174 Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5591-4.
175 Mechanism-based inactivation of CYP3A by HIV protease inhibitors. J Pharmacol Exp Ther. 2005 Feb;312(2):583-91.
176 Studies of the toxicological potential of capsinoids, XIII: inhibitory effects of capsaicin and capsinoids on cytochrome P450 3A4 in human liver microsomes. Int J Toxicol. 2010 Mar;29(2 Suppl):22S-6S.
177 Investigation of the effects of axitinib on the pharmacokinetics of loperamide and its main metabolite N-demethylated loperamide in rats by UPLC-MS/MS. Chem Biol Interact. 2019 Sep 1;310:108744. doi: 10.1016/j.cbi.2019.108744. Epub 2019 Jul 9.
178 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
179 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
180 Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
181 Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray. Cancer Lett. 2005 Apr 8;220(2):197-210.
182 Antineoplastic effects of gamma linolenic Acid on hepatocellular carcinoma cell lines. J Clin Biochem Nutr. 2010 Jul;47(1):81-90.
183 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
184 Adipogenic Effects and Gene Expression Profiling of Firemaster? 550 Components in Human Primary Preadipocytes. Environ Health Perspect. 2017 Sep 14;125(9):097013. doi: 10.1289/EHP1318.
185 Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids. Arch Toxicol. 2022 Jan;96(1):195-210. doi: 10.1007/s00204-021-03177-y. Epub 2021 Oct 23.
186 Arsenic trioxide induces differentiation of cancer stem cells in hepatocellular carcinoma through inhibition of LIF/JAK1/STAT3 and NF-kB signaling pathways synergistically. Clin Transl Med. 2021 Feb;11(2):e335. doi: 10.1002/ctm2.335.
187 Downregulation of glucose-6-phosphatase expression contributes to fluoxetine-induced hepatic steatosis. J Appl Toxicol. 2021 Aug;41(8):1232-1240. doi: 10.1002/jat.4109. Epub 2020 Nov 12.
188 Teriflunomide is an indirect human constitutive androstane receptor (CAR) activator interacting with epidermal growth factor (EGF) signaling. Front Pharmacol. 2018 Oct 11;9:993.
189 Withaferin A: A potential selective glucocorticoid receptor modulator with anti-inflammatory effect. Food Chem Toxicol. 2023 Sep;179:113949. doi: 10.1016/j.fct.2023.113949. Epub 2023 Jul 17.
190 DNA microarray analysis of vitamin D-induced gene expression in a human colon carcinoma cell line. Physiol Genomics. 2004 Apr 13;17(2):122-9. doi: 10.1152/physiolgenomics.00002.2003.
191 Retinoic acid via RARalpha inhibits the expression of 24-hydroxylase in human prostate stromal cells. Biochem Biophys Res Commun. 2005 Dec 30;338(4):1973-81. doi: 10.1016/j.bbrc.2005.10.178. Epub 2005 Nov 7.
192 Actions of Vitamin D3, analogs on human prostate cancer cell lines: comparison with 1,25-dihydroxyvitamin D3. Endocrinology. 1995 Jan;136(1):20-6.
193 Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
194 Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
195 Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia. J Clin Invest. 2005 Jan;115(1):177-86.
196 19-Nor-1,25(OH)2D2 (a novel, noncalcemic vitamin D analogue), combined with arsenic trioxide, has potent antitumor activity against myeloid leukemia. Cancer Res. 2005 Mar 15;65(6):2488-97.
197 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
198 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
199 Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures. Toxicol Sci. 2014 Oct;141(2):538-46. doi: 10.1093/toxsci/kfu151. Epub 2014 Jul 23.
200 Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
201 Expression and regulation of the bile acid transporter, OSTalpha-OSTbeta in rat and human intestine and liver. Biopharm Drug Dispos. 2009 Jul;30(5):241-58.
202 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
203 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
204 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
205 Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
206 Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42.
207 Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
208 Anti-androgenic effect of 6-formylindolo[3,2-b]carbazole (FICZ) in LNCaP cells is mediated by the aryl hydrocarbon-androgen receptors cross-talk. Steroids. 2020 Jan;153:108508. doi: 10.1016/j.steroids.2019.108508. Epub 2019 Oct 3.
209 Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition. Arch Toxicol. 2008 Dec;82(12):909-21.
210 Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density. J Bone Miner Res. 2005 Feb;20(2):232-9. doi: 10.1359/JBMR.041110. Epub 2004 Nov 16.
211 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
212 Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
213 The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol. Arch Toxicol. 2013 Apr;87(4):633-43.
214 Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Gastroenterology. 2004 Nov;127(5):1436-45.
215 In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions. Basic Clin Pharmacol Toxicol. 2008 Aug;103(2):157-65.
216 Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo. J Asian Nat Prod Res. 2012;14(4):382-95.
217 Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.
218 Stiripentol. Expert Opin Investig Drugs. 2005 Jul;14(7):905-11.
219 Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):843-52.
220 Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor. Drug Metab Dispos. 2003 Nov;31(11):1352-60.
221 Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. J Med Chem. 2005 Jun 2;48(11):3808-15.
222 Identification of novel agonists by high-throughput screening and molecular modelling of human constitutive androstane receptor isoform 3. Arch Toxicol. 2019 Aug;93(8):2247-2264. doi: 10.1007/s00204-019-02495-6. Epub 2019 Jul 16.
223 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
224 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
225 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
226 Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
227 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
228 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
229 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
230 Identification of Genes That Modulate Susceptibility to Formaldehyde and Imatinib by Functional Genomic Screening in Human Haploid KBM7 Cells. Toxicol Sci. 2016 May;151(1):10-22. doi: 10.1093/toxsci/kfw032. Epub 2016 Mar 22.
231 Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro. Oncotarget. 2014 Dec 30;5(24):12891-907.
232 Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. doi: 10.1002/cam4.1179. Epub 2017 Sep 27.
233 Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 2013 Mar;3(3):308-23.
234 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
235 Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance. Exp Cell Res. 2012 Jun 10;318(10):1146-59.
236 Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
237 Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin. Toxicol Mech Methods. 2017 Mar;27(3):165-172. doi: 10.1080/15376516.2016.1273424. Epub 2017 Jan 8.
238 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
239 Long-term exposure to zidovudine delays cell cycle progression, induces apoptosis, and decreases telomerase activity in human hepatocytes. Toxicol Sci. 2009 Sep;111(1):120-30. doi: 10.1093/toxsci/kfp136. Epub 2009 Jun 18.
240 ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis. J Biol Chem. 2006 Sep 29;281(39):28764-71. doi: 10.1074/jbc.M604392200. Epub 2006 Aug 3.
241 PARP inhibition restores extrinsic apoptotic sensitivity in glioblastoma. PLoS One. 2014 Dec 22;9(12):e114583. doi: 10.1371/journal.pone.0114583. eCollection 2014.
242 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
243 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
244 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
245 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
246 Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo. J Invest Dermatol. 2006 Apr;126(4):732-9. doi: 10.1038/sj.jid.5700202.
247 Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain Res. 2008 Jan 29;1191:1-11.
248 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
249 Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
250 Ultradian cortisol pulsatility encodes a distinct, biologically important signal. PLoS One. 2011 Jan 18;6(1):e15766.
251 Effects of progesterone treatment on expression of genes involved in uterine quiescence. Reprod Sci. 2011 Aug;18(8):781-97.
252 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
253 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Pharmacogenomics J. 2014 Feb;14(1):35-40. doi: 10.1038/tpj.2013.3. Epub 2013 Feb 12.
254 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
255 Nicotinic modulation of gene expression in SH-SY5Y neuroblastoma cells. Brain Res. 2006 Oct 20;1116(1):39-49.
256 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
257 Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. Autophagy. 2018;14(8):1435-1455. doi: 10.1080/15548627.2018.1474314. Epub 2018 Jul 20.
258 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
259 Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
260 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
261 Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol. 2008 Jun;46(6):2042-53. doi: 10.1016/j.fct.2008.01.049. Epub 2008 Feb 7.
262 Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
263 Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer. Cancer Res. 2007 May 15;67(10):5033-41.
264 Effect of benzo[a]pyrene on proliferation and metastasis of oral squamous cell carcinoma cells: A transcriptome analysis based on RNA-seq. Environ Toxicol. 2022 Nov;37(11):2589-2604. doi: 10.1002/tox.23621. Epub 2022 Jul 23.
265 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
266 CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
267 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
268 Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
269 Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor alpha signalling and results in tamoxifen insensitive proliferation. BMC Cancer. 2014 Apr 23;14:283.
270 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
271 Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicol Sci. 2010 Dec; 118(2):485-500.
272 Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). Toxicol Sci. 2013 Dec;136(2):328-43.
273 Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals. Chem Res Toxicol. 2017 May 15;30(5):1219-1229. doi: 10.1021/acs.chemrestox.7b00048. Epub 2017 May 4.
274 A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicol Sci. 2013 Nov;136(1):216-41.
275 Association of Arsenic Exposure with Whole Blood DNA Methylation: An Epigenome-Wide Study of Bangladeshi Adults. Environ Health Perspect. 2019 May;127(5):57011. doi: 10.1289/EHP3849. Epub 2019 May 28.
276 Study of low-density lipoprotein receptor regulation by oral (steroid) contraceptives: desogestrel, levonorgestrel and ethinyl estradiol in JEG-3 cell line and placental tissue. Contraception. 2007 Oct;76(4):297-305. doi: 10.1016/j.contraception.2007.06.011. Epub 2007 Sep 14.
277 Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression. J Biol Chem. 2020 Nov 20;295(47):15870-15882. doi: 10.1074/jbc.RA120.015623. Epub 2020 Sep 10.
278 Differential regulation of apolipoprotein B secretion from HepG2 cells by two HMG-CoA reductase inhibitors, atorvastatin and simvastatin. J Lipid Res. 1999 Jun;40(6):1078-89.
279 Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
280 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
281 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
282 ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
283 Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
284 (9)-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7-Stimulated Human Coculture. J Pharmacol Exp Ther. 2019 Oct;371(1):191-201. doi: 10.1124/jpet.119.260661. Epub 2019 Aug 5.
285 Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
286 Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. Arch Toxicol. 2018 Jun;92(6):2043-2054. doi: 10.1007/s00204-018-2199-7. Epub 2018 Mar 29.
287 Spironolactone induces apoptosis in human mononuclear cells. Association between apoptosis and cytokine suppression. Apoptosis. 2006 Apr;11(4):573-9. doi: 10.1007/s10495-006-4919-3.
288 A protein-coated magnetic beads as a tool for the rapid drug-protein binding study. J Pharm Biomed Anal. 2010 Jul 8;52(3):420-4. doi: 10.1016/j.jpba.2009.06.023. Epub 2009 Jun 18.
289 The three recombinant domains of human serum albumin. Structural characterization and ligand binding properties. J Biol Chem. 1999 Oct 8;274(41):29303-10. doi: 10.1074/jbc.274.41.29303.
290 Exploring binding properties of sertraline with human serum albumin: Combination of spectroscopic and molecular modeling studies. Chem Biol Interact. 2015 Dec 5;242:235-46. doi: 10.1016/j.cbi.2015.10.006. Epub 2015 Oct 22.
291 Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
292 Use of peak decay analysis and affinity microcolumns containing silica monoliths for rapid determination of drug-protein dissociation rates. J Chromatogr A. 2011 Apr 15;1218(15):2072-8. doi: 10.1016/j.chroma.2010.09.070. Epub 2010 Oct 16.
293 [Colchicine in chronic liver disease of alcoholic etiology. Double-blind, randomized study of its effects on blood levels of plasma proteins and clinical course in patients]. Rev Assoc Med Bras (1992). 1995 May-Jun;41(3):207-12.
294 Editor's Highlight: Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues. Toxicol Sci. 2016 Dec;154(2):354-367. doi: 10.1093/toxsci/kfw169. Epub 2016 Sep 7.
295 Covalent binding of the flavonoid quercetin to human serum albumin. J Agric Food Chem. 2005 May 18;53(10):4194-7. doi: 10.1021/jf050061m.
296 Estrogen-like activity of metals in MCF-7 breast cancer cells. Endocrinology. 2003 Jun;144(6):2425-36. doi: 10.1210/en.2002-221054.
297 Cross-talk between non-genomic and genomic signalling pathways--distinct effect profiles of environmental estrogens. Toxicol Appl Pharmacol. 2010 Jun 1;245(2):160-70. doi: 10.1016/j.taap.2010.02.015. Epub 2010 Mar 4.
298 Bidirectional cross talk between ERalpha and EGFR signalling pathways regulates tamoxifen-resistant growth. Breast Cancer Res Treat. 2006 Mar;96(2):131-46. doi: 10.1007/s10549-005-9070-2. Epub 2005 Oct 27.
299 Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry. Odontology. 2013 Jan;101(1):43-51.
300 The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res. 2005 Jan 1;65(1):18-25.
301 Antitumoral activity of liraglutide, a new DNMT inhibitor in breast cancer cells in vitro and in vivo. Chem Biol Interact. 2021 Nov 1;349:109641. doi: 10.1016/j.cbi.2021.109641. Epub 2021 Sep 14.
302 Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells. Mol Pharmacol. 2001 Sep;60(3):595-602.
303 Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth. Br J Cancer. 2007 Apr 23;96(8):1204-15. doi: 10.1038/sj.bjc.6603705. Epub 2007 Mar 27.
304 Prediction of the combined effects of multiple estrogenic chemicals on MCF-7 human breast cancer cells and a preliminary molecular exploration of the estrogenic proliferative effects and related gene expression. Ecotoxicol Environ Saf. 2018 Sep 30;160:1-9. doi: 10.1016/j.ecoenv.2018.05.025. Epub 2018 May 21.
305 Simvastatin protects neurons from cytotoxicity by up-regulating Bcl-2 mRNA and protein. J Neurochem. 2007 Apr;101(1):77-86. doi: 10.1111/j.1471-4159.2006.04375.x. Epub 2007 Jan 4.
306 Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease. J Struct Biol. 2000 Jun;130(2-3):209-16. doi: 10.1006/jsbi.2000.4285.
307 Increased processing of APLP2 and APP with concomitant formation of APP intracellular domains in BDNF and retinoic acid-differentiated human neuroblastoma cells. J Neurochem. 2005 Nov;95(4):1059-68. doi: 10.1111/j.1471-4159.2005.03440.x. Epub 2005 Sep 7.
308 Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
309 Synergistic effects of iron and aluminum on stress-related gene expression in primary human neural cells. J Alzheimers Dis. 2005 Nov;8(2):117-27; discussion 209-15. doi: 10.3233/jad-2005-8204.
310 Thyroid function and plasma concentrations of polyhalogenated compounds in Inuit adults. Environ Health Perspect. 2009 Sep;117(9):1380-6. doi: 10.1289/ehp.0900633. Epub 2009 May 12.
311 A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
312 Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
313 Pleiotropic beta-agonist-promoted receptor conformations and signals independent of intrinsic activity. Am J Respir Cell Mol Biol. 2007 Feb;36(2):236-43. doi: 10.1165/rcmb.2006-0257OC. Epub 2006 Sep 15.
314 Development of 3D-QSAR models for predicting the activities of chemicals to stimulate muscle growth via (2)-adrenoceptor. Toxicol In Vitro. 2021 Dec;77:105251. doi: 10.1016/j.tiv.2021.105251. Epub 2021 Sep 30.
315 Beta2-adrenergic receptor polymorphisms in African American children with status asthmaticus. Pediatr Crit Care Med. 2006 Jan;7(1):15-8. doi: 10.1097/01.pcc.0000194010.63115.a2.
316 beta2-adrenergic receptor polymorphisms and salbutamol-stimulated energy expenditure. J Clin Endocrinol Metab. 2005 Apr;90(4):2301-7. doi: 10.1210/jc.2004-1356. Epub 2005 Feb 1.
317 Neutrophil beta(2)-adrenoceptor function in major depression: G(s) coupling, effects of imipramine and relationship to treatment outcome. Eur J Pharmacol. 1999 Dec 15;386(2-3):135-44. doi: 10.1016/s0014-2999(99)00749-9.
318 Myocardial ischaemia and ventricular arrhthymias precipitated by physiological concentrations of adrenaline in patients with coronary artery disease. Br Heart J. 1992 May;67(5):419-20. doi: 10.1136/hrt.67.5.419-b.
319 Histamine augments beta2-adrenoceptor-induced cyclic AMP accumulation in human prostate cancer cells DU-145 independently of known histamine receptors. Biochem Pharmacol. 2007 Mar 15;73(6):814-23. doi: 10.1016/j.bcp.2006.11.022. Epub 2006 Dec 1.
320 Expression of inwardly rectifying potassium channels (GIRKs) and beta-adrenergic regulation of breast cancer cell lines. BMC Cancer. 2004 Dec 16;4:93. doi: 10.1186/1471-2407-4-93.
321 Evaluation of early biomarkers of muscle anabolic response to testosterone. J Cachexia Sarcopenia Muscle. 2011 Mar;2(1):45-56. doi: 10.1007/s13539-011-0021-y. Epub 2011 Feb 26.
322 Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation. Mol Endocrinol. 2002 Jun;16(6):1243-56.
323 Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors. Arthritis Rheum. 2012 Dec;64(12):3856-66. doi: 10.1002/art.37691.
324 In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
325 Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
326 Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol. 2012 May;57(5):483-90. doi: 10.1016/j.archoralbio.2011.10.007. Epub 2011 Nov 25.
327 Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
328 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
329 Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med. 2000 Jan;161(1):249-56. doi: 10.1164/ajrccm.161.1.9804096.
330 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
331 Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
332 Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
333 Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
334 Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
335 Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
336 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
337 -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
338 Effects of all-trans and 9-cis retinoic acid on differentiating human neural stem cells in vitro. Toxicology. 2023 Mar 15;487:153461. doi: 10.1016/j.tox.2023.153461. Epub 2023 Feb 16.
339 Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
340 Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
341 Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
342 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
343 Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
344 Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation. Toxicol Appl Pharmacol. 2021 Mar 15;415:115450. doi: 10.1016/j.taap.2021.115450. Epub 2021 Feb 9.
345 Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.
346 A copper-hydrogen peroxide redox system induces dityrosine cross-links and chemokine oligomerisation. Cytokine. 2011 Dec;56(3):669-75. doi: 10.1016/j.cyto.2011.08.025. Epub 2011 Oct 1.
347 Regulatory role of nitric oxide on monocyte-derived dendritic cell functions. J Interferon Cytokine Res. 2003 Aug;23(8):423-31. doi: 10.1089/107999003322277838.
348 Simvastatin down regulates mRNA expression of RANTES and CCR5 in posttransplant renal recipients with hyperlipidemia. Transplant Proc. 2006 Nov;38(9):2899-904. doi: 10.1016/j.transproceed.2006.08.136.
349 13-cis retinoic acid inhibits development and progression of chronic allograft nephropathy. Am J Pathol. 2005 Jul;167(1):285-98. doi: 10.1016/S0002-9440(10)62973-2.
350 Identification of human cell responses to benzene and benzene metabolites. Genomics. 2007 Sep;90(3):324-33.
351 Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents. Leuk Res. 2010 Jul;34(7):917-24. doi: 10.1016/j.leukres.2009.12.002. Epub 2010 Feb 8.
352 Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. Bioorg Med Chem. 2007 Jul 15;15(14):4863-75. doi: 10.1016/j.bmc.2007.04.057. Epub 2007 May 3.
353 Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3. Arch Toxicol. 2022 Jan;96(1):177-193. doi: 10.1007/s00204-021-03174-1. Epub 2021 Oct 19.
354 Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
355 Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. J Toxicol Sci. 2015 Jun;40(3):329-38. doi: 10.2131/jts.40.329.
356 Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Implication for its cardiac developmental toxicity. Toxicology. 2020 Apr 15;435:152422. doi: 10.1016/j.tox.2020.152422. Epub 2020 Feb 26.
357 Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochem Pharmacol. 2011 Feb 15;81(4):510-7. doi: 10.1016/j.bcp.2010.11.014. Epub 2010 Nov 27.
358 Actinomycin D inhibits the expression of the cystine/glutamate transporter xCT via attenuation of CD133 synthesis in CD133(+) HCC. Chem Biol Interact. 2019 Aug 25;309:108713. doi: 10.1016/j.cbi.2019.06.026. Epub 2019 Jun 19.
359 Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells. Ann Hematol. 2010 Nov;89(11):1115-24. doi: 10.1007/s00277-010-0988-z. Epub 2010 May 25.
360 The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
361 The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. DNA Repair (Amst). 2004 Mar 4;3(3):235-44. doi: 10.1016/j.dnarep.2003.10.014.
362 MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
363 Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
364 Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
365 Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
366 Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter. Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E236-45. doi: 10.1152/ajpendo.00144.2004.
367 Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse. Pharmacogenomics J. 2003;3(1):27-40.
368 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
369 Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
370 Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
371 G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J Biol Chem. 1993 Apr 15;268(11):8298-308.
372 Sulindac induces specific degradation of the HPV oncoprotein E7 and causes growth arrest and apoptosis in cervical carcinoma cells. Cancer Lett. 2007 Jan 8;245(1-2):103-11. doi: 10.1016/j.canlet.2005.12.034. Epub 2006 Feb 20.
373 CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models. Genes Cancer. 2014 Jul;5(7-8):261-72. doi: 10.18632/genesandcancer.24.
374 [Reversal effect of MDR1 and MDR3 gene silencing on resistance of A2780/taxol cells to paclitaxel]. Zhonghua Fu Chan Ke Za Zhi. 2007 Jun;42(6):412-6.
375 8-Methoxypsoralen disrupts MDR3-mediated phospholipids efflux and bile acid homeostasis and its relevance to hepatotoxicity. Toxicology. 2017 Jul 1;386:40-48. doi: 10.1016/j.tox.2017.05.011. Epub 2017 May 24.
376 Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
377 Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
378 Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR. Yakugaku Zasshi. 2002 May;122(5):339-61.
379 Human oligodendrocytes derived from embryonic stem cells: Effect of noggin on phenotypic differentiation in vitro and on myelination in vivo. Mol Cell Neurosci. 2007 Mar;34(3):310-23. doi: 10.1016/j.mcn.2006.11.008. Epub 2006 Dec 28.
380 Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
381 The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling. Oncogene. 2001 Feb 1;20(5):645-53. doi: 10.1038/sj.onc.1204123.
382 Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines. Breast. 2018 Oct;41:34-41. doi: 10.1016/j.breast.2018.06.009. Epub 2018 Jun 22.
383 Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
384 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
385 Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. Eur Rev Med Pharmacol Sci. 2016;20(6):1203-13.
386 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
387 Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells. J Pharmacol Exp Ther. 2001 Sep;298(3):976-85.
388 Estrogen receptor regulates E2F1 expression to mediate tamoxifen resistance. Mol Cancer Res. 2010 Mar;8(3):343-52. doi: 10.1158/1541-7786.MCR-09-0395. Epub 2010 Mar 9.
389 Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
390 Fluoxetine mediates G0/G1 arrest by inducing functional inhibition of cyclin dependent kinase subunit (CKS)1. Biochem Pharmacol. 2008 May 15;75(10):1924-34. doi: 10.1016/j.bcp.2008.02.013. Epub 2008 Feb 17.
391 Troglitazone suppresses cell growth of KU812 cells independently of PPARgamma. Eur J Pharmacol. 2002 Feb 1;436(1-2):7-13. doi: 10.1016/s0014-2999(01)01577-1.
392 Retinoic acid regulates cell cycle progression and cell differentiation in human monocytic THP-1 cells. Exp Cell Res. 2004 Jul 1;297(1):68-81. doi: 10.1016/j.yexcr.2004.02.017.
393 [P27(Kip1), cyclin E and endogenous TGF-beta1 changes in apoptosis of NB4 cells induced by As(2)O(3) and/or TGF-beta1 and their significance]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Feb;17(1):74-9.
394 Epigenetic silencing of novel tumor suppressors in malignant melanoma. Cancer Res. 2006 Dec 1;66(23):11187-93. doi: 10.1158/0008-5472.CAN-06-1274.
395 Combined contributions of over-secreted glucagon-like peptide 1 and suppressed insulin secretion to hyperglycemia induced by gatifloxacin in rats. Toxicol Appl Pharmacol. 2013 Feb 1;266(3):375-84. doi: 10.1016/j.taap.2012.11.015. Epub 2012 Nov 28.
396 Bisphenol A effects on gene expression in adipocytes from children: association with metabolic disorders. J Mol Endocrinol. 2015 Jun;54(3):289-303.
397 Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
398 Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
399 Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. Mol Cancer. 2010 Aug 20;9:220.
400 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
401 Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway. J Biochem Mol Toxicol. 2023 Jun;37(6):e23328. doi: 10.1002/jbt.23328. Epub 2023 Feb 19.
402 Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
403 Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2015 Mar;35(3):1063-76. doi: 10.1111/liv.12626. Epub 2014 Jul 30.
404 Synergistic effects of retinoic acid and tamoxifen on human breast cancer cells: proteomic characterization. Exp Cell Res. 2007 Jan 15;313(2):357-68. doi: 10.1016/j.yexcr.2006.10.016. Epub 2006 Oct 25.
405 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
406 Docosahexaenoic acid regulates gene expression in HUVEC cells treated with polycyclic aromatic hydrocarbons. Toxicol Lett. 2015 Jul 16;236(2):75-81.
407 Etoposide induces necrosis through p53-mediated antiapoptosis in human kidney proximal tubule cells. Toxicol Sci. 2015 Nov;148(1):204-19.
408 Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. Br J Nutr. 2006 Nov;96(5):811-9.
409 COX-2 and PPAR-gama confer cannabidiol-induced apoptosis of human lung cancer cells. Mol Cancer Ther. 2013 Jan;12(1):69-82.
410 Mitochondrial involvement in schizophrenia and other functional psychoses. Neurochem Res. 1996 Sep;21(9):995-1004.
411 Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression. Eur Neuropsychopharmacol. 2007 Dec;17(12):774-80.
412 Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer. Cancer Res. 2006 Feb 15;66(4):2067-73.
413 A2E selectively induces cox-2 in ARPE-19 and human neural cells. Curr Eye Res. 2006 Mar;31(3):259-63.
414 Genome-wide transcriptional and functional analysis of human T lymphocytes treated with benzo[alpha]pyrene. Int J Mol Sci. 2018 Nov 17;19(11).
415 Bisphenol A Exposure Changes the Transcriptomic and Proteomic Dynamics of Human Retinoblastoma Y79 Cells. Genes (Basel). 2021 Feb 11;12(2):264. doi: 10.3390/genes12020264.
416 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
417 Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
418 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
419 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
420 Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
421 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
422 Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
423 [Mechanisms underlying the effect of arsenic trioxide on proliferation inhibition and apoptosis induction in myeloma cell line u266]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Oct;15(5):982-5.
424 Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
425 Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
426 Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
427 Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
428 Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
429 Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
430 mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
431 Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
432 In vitro and pharmacophore-based discovery of novel hPEPT1 inhibitors. Pharm Res. 2005 Apr;22(4):512-7. doi: 10.1007/s11095-005-2505-y. Epub 2005 Apr 7.
433 Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs. Eur J Pharm Biopharm. 2011 Feb;77(2):327-31. doi: 10.1016/j.ejpb.2010.12.009. Epub 2010 Dec 13.
434 Severe villus atrophy and chronic malabsorption induced by azathioprine. Gastroenterology. 2003 Jun;124(7):1950-7.
435 Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer. Endocr Relat Cancer. 2011 Apr 28;18(3):333-45. doi: 10.1530/ERC-10-0262. Print 2011 Jun.
436 Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Arthritis Rheum. 2012 Jun;64(6):1780-9. doi: 10.1002/art.34342. Epub 2011 Dec 19.
437 Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. Melanoma Res. 2008 Apr;18(2):85-94. doi: 10.1097/CMR.0b013e3282f60097.
438 Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. Biochem Pharmacol. 2001 May 15;61(10):1205-15. doi: 10.1016/s0006-2952(01)00583-4.
439 Induction mechanism of apoptosis by troglitazone through peroxisome proliferator-activated receptor-gamma in gastric carcinoma cells. Anticancer Res. 2003 Jan-Feb;23(1A):267-73.
440 Down-regulation of CD44 contributes to the differentiation of HL-60 cells induced by ATRA or HMBA. Cell Mol Immunol. 2007 Feb;4(1):59-63.
441 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
442 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
443 Positive regulation of hepatic carnitine palmitoyl transferase 1A (CPT1A) activities by soy isoflavones and L-carnitine. Eur J Nutr. 2006 Mar;45(3):159-64. doi: 10.1007/s00394-005-0576-5. Epub 2005 Dec 20.
444 Aspirin regulates hepatocellular lipid metabolism by activating AMPK signaling pathway. J Toxicol Sci. 2015 Feb;40(1):127-36. doi: 10.2131/jts.40.127.
445 Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.
446 Bisphenol-A and estradiol exert novel gene regulation in human MCF-7 derived breast cancer cells. Mol Cell Endocrinol. 2004 Jun 30;221(1-2):47-55. doi: 10.1016/j.mce.2004.04.010.
447 Benzo[a]pyrene increases the Nrf2 content by downregulating the Keap1 message. Toxicol Sci. 2010 Aug;116(2):549-61.
448 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
449 Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes. Life Sci. 2016 Jul 1;156:47-56.
450 Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver. Arch Toxicol. 2022 Oct;96(10):2739-2754. doi: 10.1007/s00204-022-03338-7. Epub 2022 Jul 26.
451 Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
452 Regulation of type III iodothyronine deiodinase expression in human cell lines. Endocrinology. 2006 Dec;147(12):5845-54. doi: 10.1210/en.2006-0590. Epub 2006 Aug 24.
453 MAPK and SHH pathways modulate type 3 deiodinase expression in papillary thyroid carcinoma. Endocr Relat Cancer. 2016 Mar;23(3):135-46. doi: 10.1530/ERC-15-0162.
454 Screening the ToxCast Phase 1, Phase 2, and e1k Chemical Libraries for Inhibitors of Iodothyronine Deiodinases. Toxicol Sci. 2019 Apr 1;168(2):430-442. doi: 10.1093/toxsci/kfy302.
455 Disturbance of the Dlk1-Dio3 imprinted domain may underlie placental Dio3 suppression and extracellular thyroid hormone disturbance in placenta-derived JEG-3 cells following decabromodiphenyl ether (BDE209) exposure. Toxicology. 2021 Jun 30;458:152837. doi: 10.1016/j.tox.2021.152837. Epub 2021 Jun 21.
456 Microarray analysis of bicalutamide action on telomerase activity, p53 pathway and viability of prostate carcinoma cell lines. J Pharm Pharmacol. 2005 Jan;57(1):83-92.
457 Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
458 Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.
459 Differential effects of omega-3 and omega-6 Fatty acids on gene expression in breast cancer cells. Breast Cancer Res Treat. 2007 Jan;101(1):7-16. doi: 10.1007/s10549-006-9269-x. Epub 2006 Jul 6.
460 Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
461 Arsenic trioxide mediates intrinsic and extrinsic pathways of apoptosis and cell cycle arrest in acute megakaryocytic leukemia. Int J Oncol. 2005 Aug;27(2):537-45.
462 Effect of chemical mutagens and carcinogens on gene expression profiles in human TK6 cells. PLoS One. 2012;7(6):e39205. doi: 10.1371/journal.pone.0039205. Epub 2012 Jun 18.
463 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
464 Effect of zoledronic acid on oral fibroblasts and epithelial cells: a potential mechanism of bisphosphonate-associated osteonecrosis. Br J Haematol. 2009 Mar;144(5):667-76. doi: 10.1111/j.1365-2141.2008.07504.x. Epub 2008 Nov 20.
465 Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
466 Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death. Mol Pharmacol. 2005 May;67(5):1808-17. doi: 10.1124/mol.104.005769. Epub 2005 Feb 9.
467 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
468 Role of BAX in the apoptotic response to anticancer agents. Science. 2000 Nov 3;290(5493):989-92. doi: 10.1126/science.290.5493.989.
469 Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene. 2005 Feb 10;24(7):1231-43. doi: 10.1038/sj.onc.1208290.
470 Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. Int J Cancer. 2008 Aug 15;123(4):951-7. doi: 10.1002/ijc.23593.
471 Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
472 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
473 Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13.
474 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
475 Marked regression of liver metastasis by combined therapy of ultrasound-mediated NF kappaB-decoy transfer and transportal injection of paclitaxel, in mouse. Int J Cancer. 2008 Apr 1;122(7):1645-56. doi: 10.1002/ijc.23280.
476 Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells. Carcinogenesis. 2006 May;27(5):916-24. doi: 10.1093/carcin/bgi312. Epub 2005 Dec 16.
477 In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
478 Changes in gene expressions elicited by physiological concentrations of genistein on human endometrial cancer cells. Mol Carcinog. 2006 Oct;45(10):752-63.
479 Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
480 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
481 Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
482 Association of GRIK4 with outcome of antidepressant treatment in the STAR*D cohort. Am J Psychiatry. 2007 Aug;164(8):1181-8. doi: 10.1176/appi.ajp.2007.06111790.
483 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
484 The PPAR gamma agonist troglitazone induces musclin mRNA expression in human myotubes. Horm Metab Res. 2006 Sep;38(9):614-6. doi: 10.1055/s-2006-951310.
485 Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression. Biochim Biophys Acta. 2006 Mar-Apr;1759(3-4):141-51. doi: 10.1016/j.bbaexp.2006.04.005. Epub 2006 Apr 27.
486 Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
487 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
488 Comprehensive transcriptome profiling of BET inhibitor-treated HepG2 cells. PLoS One. 2022 Apr 29;17(4):e0266966. doi: 10.1371/journal.pone.0266966. eCollection 2022.
489 Characterization of the Molecular Alterations Induced by the Prolonged Exposure of Normal Colon Mucosa and Colon Cancer Cells to Low-Dose Bisphenol A. Int J Mol Sci. 2022 Oct 1;23(19):11620. doi: 10.3390/ijms231911620.
490 Gene expression changes in primary human nasal epithelial cells exposed to formaldehyde in vitro. Toxicol Lett. 2010 Oct 5;198(2):289-95.
491 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
492 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet. 2013 Feb;45(2):145-54. doi: 10.1038/ng.2500. Epub 2012 Dec 23.
493 Cardiac toxicity from ethanol exposure in human-induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci. 2019 May 1;169(1):280-292.
494 Peroxisome proliferator activated receptor gamma (PPAR-gama) ligand pioglitazone regulated gene networks in term human primary trophoblast cells. Reprod Toxicol. 2018 Oct;81:99-107.
495 Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells. Mol Cancer Ther. 2012 Oct;11(10):2138-48. doi: 10.1158/1535-7163.MCT-12-0562. Epub 2012 Aug 6.
496 Cystathionine metabolic enzymes play a role in the inflammation resolution of human keratinocytes in response to sub-cytotoxic formaldehyde exposure. Toxicol Appl Pharmacol. 2016 Nov 1;310:185-194.
497 Riboflavin depletion impairs cell proliferation in adult human duodenum: identification of potential effectors. Dig Dis Sci. 2011 Apr;56(4):1007-19. doi: 10.1007/s10620-010-1374-3. Epub 2010 Sep 17.
498 Effect of prenatal arsenic exposure on DNA methylation and leukocyte subpopulations in cord blood. Epigenetics. 2014 May;9(5):774-82. doi: 10.4161/epi.28153. Epub 2014 Feb 13.
499 A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302. doi: 10.1371/journal.pone.0178302. eCollection 2017.
500 Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food Chem Toxicol. 2020 Feb;136:111047. doi: 10.1016/j.fct.2019.111047. Epub 2019 Dec 12.
501 Susceptibility to drug-induced apoptosis correlates with differential modulation of Bad, Bcl-2 and Bcl-xL protein levels. Cell Death Differ. 2000 Jun;7(6):574-86. doi: 10.1038/sj.cdd.4400688.
502 Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells. Cancer Res. 2003 Feb 1;63(3):616-20.
503 Simvastatin induces activation of the serine-threonine protein kinase AKT and increases survival of isolated human pancreatic islets. Transplantation. 2002 Oct 27;74(8):1063-9. doi: 10.1097/00007890-200210270-00001.
504 Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Mol Cell Biochem. 2010 Nov;344(1-2):173-84. doi: 10.1007/s11010-010-0540-4. Epub 2010 Jul 25.
505 Down regulation of N-acetylglucosaminyltransferase V facilitates all-transretinoic acid to induce apoptosis of human hepatocarcinoma cells. Mol Cell Biochem. 2006 Mar;284(1-2):103-10. doi: 10.1007/s11010-005-9022-5. Epub 2006 Jan 13.
506 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
507 Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
508 Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells. Toxicol Appl Pharmacol. 2017 Sep 15;331:154-163.
509 NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
510 Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
511 Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
512 Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
513 Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
514 Characterizing the genetic basis for nicotine induced cancer development: a transcriptome sequencing study. PLoS One. 2013 Jun 18;8(6):e67252.
515 Effect of mood stabilizers on gene expression in lymphoblastoid cells. J Neural Transm (Vienna). 2010 Feb;117(2):155-64.
516 Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
517 Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
518 Highly conserved mouse and human brain sulfotransferases: molecular cloning, expression, and functional characterization. Gene. 2002 Feb 20;285(1-2):39-47. doi: 10.1016/s0378-1119(02)00431-6.
519 Metabolic patterns and biotransformation activities of resveratrol in human glioblastoma cells: relevance with therapeutic efficacies. PLoS One. 2011;6(11):e27484.
520 Effect of 1 alpha-hydroxyvitamin D3 on serum levels of thyroid hormones in hyperthyroid patients with untreated Graves' disease. Metabolism. 1997 Oct;46(10):1184-8. doi: 10.1016/s0026-0495(97)90214-6.
521 Long-term efficacy and tolerability of octreotide treatment in acromegaly. Metabolism. 1992 Sep;41(9 Suppl 2):44-50. doi: 10.1016/0026-0495(92)90030-e.
522 Effects of terguride on anterior pituitary function in parkinsonian patients treated with L-dopa: a double-blind study versus placebo. Clin Neuropharmacol. 1996 Feb;19(1):72-80. doi: 10.1097/00002826-199619010-00006.
523 Post-myocardial infarction mortality in patients with ventricular premature depolarizations. Canadian Amiodarone Myocardial Infarction Arrhythmia Trial Pilot Study. Circulation. 1991 Aug;84(2):550-7. doi: 10.1161/01.cir.84.2.550.
524 Dynamic monitoring of cardio-specific markers and markers of thyroid gland function in cancer patients--a pilot study. Anticancer Res. 2007 Jul-Aug;27(4A):1883-6.
525 Goitrogenic anions, thyroid-stimulating hormone, and thyroid hormone in infants. Environ Health Perspect. 2010 Sep;118(9):1332-7. doi: 10.1289/ehp.0901736. Epub 2010 Apr 27.
526 Enhanced photodynamic effect of cobalt(III) dipyridophenazine complex on thyrotropin receptor expressing HEK293 cells. Metallomics. 2010 Nov;2(11):754-65. doi: 10.1039/c0mt00028k. Epub 2010 Oct 21.
527 Thyroid organotypic rat and human cultures used to investigate drug effects on thyroid function, hormone synthesis and release pathways. Toxicol Appl Pharmacol. 2012 Apr 1;260(1):81-8. doi: 10.1016/j.taap.2012.01.029. Epub 2012 Feb 8.
528 Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
529 Regulation of type 1 iodothyronine deiodinase in health and disease. Thyroid. 2005 Aug;15(8):835-40. doi: 10.1089/thy.2005.15.835.
530 Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine. Clin Pharmacol Ther. 2006 Nov;80(5):440-456.