Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPIM9L)

• Drug Name: PMID28870136-Compound-48 Drug Info
• Cross-matching ID:
  PubChem CID: 2153
  ChEBI ID: CHEBI:28177
  CAS Number: CAS 58-55-9
  TTD Drug ID: DMPIM9L
  ACDINA Drug ID: D00670

Molecule-Related Drug Atlas

Drug(s) Targeting Ecto-5'-nucleotidase (CD73)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TJ004309	DMFB54Y	Ovarian cancer	2C73	Phase 2	[6]
GS-1423	DMS25DL	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
Oleclumab	DMLVNWO	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
AB680	DMGONUE	Pancreatic cancer	2C10	Phase 1	[9]
TJ4309	DMM3U2Q	Solid tumour/cancer	2A00-2F9Z	Phase 1	[10]
CPI-006	DMJSFTX	Advanced cancer	2A00-2F9Z	Phase 1	[11]
LY3475070	DMZLIWX	Solid tumour/cancer	2A00-2F9Z	Phase 1	[12]
NZV930	DMWN2FP	Solid tumour/cancer	2A00-2F9Z	Phase 1	[13]
PMID28870136-Compound-57	DME3HLC	N. A.	N. A.	Patented	[1]
PMID28870136-Compound-46	DM4FD7C	N. A.	N. A.	Patented	[1]

Drug(s) Affected By Lactotransferrin (LTF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[14]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[15]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[16]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[17]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[18]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[21]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[14]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[22]

Drug(s) Affected By Myeloperoxidase (MPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[23]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[26]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[27]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[30]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[31]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[32]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[33]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[34]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[35]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[36]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[37]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[39]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[37]

Drug(s) Affected By Centrosomal protein of 290 kDa (CEP290)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[46]
Bortezomib	DMNO38U	Leukemia		Approved	[47]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[48]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]

Drug(s) Affected By Pleiotropic regulator 1 (PLRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[50]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[54]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[55]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[56]

Drug(s) Affected By Checkpoint protein HUS1 (HUS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[62]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]

Drug(s) Affected By Tubulin-specific chaperone A (TBCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[62]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[65]

Drug(s) Affected By Glutaredoxin-3 (GLRX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[68]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[68]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[47]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]

Drug(s) Affected By CSC1-like protein 1 (TMEM63A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[70]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[40]

Drug(s) Affected By Interleukin-6 receptor subunit alpha (IL6R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[71]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[76]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[77]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[78]

Drug(s) Affected By Fibrocystin (PKHD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[83]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[88]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[89]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[90]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[89]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[91]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]

Drug(s) Affected By Histone H2A type 1 (H2AC11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[94]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[95]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[96]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[97]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 2 (PTPN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[3]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[100]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[55]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[101]

Drug(s) Affected By Diamine oxidase (AOC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Amiloride	DMRTSGP	Congestive heart failure	BD10	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[104]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[105]
Aminoguanidine	DMJQDUC	Diabetic retinopathy	9B71.0	Phase 1	[102]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
Putrescine	DMWE6V1	Burn and burn infection	ND90-NE2Z	Discontinued in Phase 2	[102]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]

Drug(s) Affected By D(1B) dopamine receptor (DRD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
LE-300	DMGJL16	Schizophrenia	6A20	Preclinical	[108]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase epsilon (PTPRE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[110]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[112]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[46]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]

Drug(s) Affected By G protein-coupled receptor kinase 3 (GRK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[3]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[114]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[115]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[40]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[116]

Drug(s) Affected By Chymotrypsin-like protease CTRL-1 (CTRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[55]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]
Plumbagin	DM9BS50	Discovery agent	N.A.	Investigative	[118]
CH-223191	DMMJZYC	Solid tumour/cancer	2A00-2F9Z	Investigative	[119]

Drug(s) Affected By Epidermal growth factor receptor substrate 15 (EPS15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[81]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[122]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]

Drug(s) Affected By Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[123]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[124]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[125]

Drug(s) Affected By Arf-GAP domain and FG repeat-containing protein 1 (AGFG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[126]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[128]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[114]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[130]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[75]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit B (EIF3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[133]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[97]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[46]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[134]

Drug(s) Affected By Small ribosomal subunit protein uS19 (RPS15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[135]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[136]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[137]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[138]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[65]

Drug(s) Affected By Myocyte-specific enhancer factor 2A (MEF2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[139]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[134]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[140]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[141]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[114]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[134]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[142]

Drug(s) Affected By Mitotic-spindle organizing protein 1 (MZT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[96]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[46]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[143]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[55]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[130]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[143]

Drug(s) Affected By Nucleosome-remodeling factor subunit BPTF (BPTF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]

Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[3]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[145]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[146]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[149]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[150]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[48]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[97]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[81]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[115]

Drug(s) Affected By Caprin-1 (CAPRIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[154]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[47]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[46]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[155]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[156]

Drug(s) Affected By BOS complex subunit NOMO1 (NOMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[128]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[157]

Drug(s) Affected By TATA box-binding protein-associated factor RNA polymerase I subunit A (TAF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[156]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[116]
Piperazinyl methyl quinazolinone derivative 2	DM913KS	N. A.	N. A.	Patented	[158]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[97]

Drug(s) Affected By Ras-related protein Rab-11B (RAB11B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[161]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[162]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[163]

Drug(s) Affected By Neuronal regeneration-related protein (NREP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[165]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[165]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[97]

Drug(s) Affected By Protein CLEC16A (CLEC16A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[46]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[167]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]

Drug(s) Affected By Proline and serine-rich protein 3 (PROSER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[47]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[169]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[170]

Drug(s) Affected By WD40 repeat-containing protein SMU1 (SMU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[54]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[48]

Drug(s) Affected By LETM1 domain-containing protein LETM2, mitochondrial (LETM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[140]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[83]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[117]

Drug(s) Affected By Ankyrin repeat and death domain-containing protein 1A (ANKDD1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[171]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[97]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[46]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[172]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[172]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[114]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]

Drug(s) Affected By Rho GTPase-activating protein 15 (ARHGAP15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[97]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[81]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[174]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[100]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[97]

Drug(s) Affected By Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial (EARS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[173]

Drug(s) Affected By Coiled-coil domain-containing protein 181 (CCDC181)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[114]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[173]

Drug(s) Affected By G kinase-anchoring protein 1 (GKAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[60]
Bortezomib	DMNO38U	Leukemia		Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[128]

Drug(s) Affected By Protein Jade-1 (JADE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[176]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[177]

Drug(s) Affected By Superkiller complex protein 3 (SKIC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[54]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[40]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[55]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[130]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[176]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[173]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[178]

Drug(s) Affected By Uncharacterized protein NKAPD1 (NKAPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[114]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[179]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[180]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[75]

Drug(s) Affected By Vacuolar fusion protein MON1 homolog B (MON1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[181]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By Protein RIC-3 (RIC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[55]

Drug(s) Affected By Allergin-1 (MILR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[70]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]

Drug(s) Affected By Somatomedin-B and thrombospondin type-1 domain-containing protein (SBSPON)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[182]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[183]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[114]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]

Drug(s) Affected By Retinol dehydrogenase 10 (RDH10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[184]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[185]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[186]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]

Drug(s) Affected By Olfactory receptor 4N4 (OR4N4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]

Drug(s) Affected By C-type lectin domain family 4 member F (CLEC4F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[174]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]

Drug(s) Affected By Integral membrane protein GPR137C (GPR137C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[187]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[117]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[55]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[56]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[75]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[188]

Drug(s) Affected By Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (ANKRD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[3]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[173]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[100]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[55]

Drug(s) Affected By Modulator of smoothened protein (MOSMO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[46]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[189]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]

Drug(s) Affected By tRNA methyltransferase 10 homolog A (TRMT10A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[55]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[143]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[179]

Drug(s) Affected By Minor histocompatibility antigen H13 (HM13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[187]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[163]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[181]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]

Drug(s) Affected By Proline-rich AKT1 substrate 1 (AKT1S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[107]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Cabazitaxel	DMPAZHC	Breast cancer	2C60-2C65	Approved	[192]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[193]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]

Drug(s) Affected By Nucleus accumbens-associated protein 2 (NACC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[46]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[62]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[115]

Drug(s) Affected By 5-methylcytosine rRNA methyltransferase NSUN4 (NSUN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]

Drug(s) Affected By Transmembrane protein 19 (TMEM19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[171]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[194]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[81]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[195]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[195]

Drug(s) Affected By Protein disulfide-isomerase TMX3 (TMX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[196]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[173]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[176]

Drug(s) Affected By Adenosine deaminase domain-containing protein 1 (ADAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[83]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]

Drug(s) Affected By Eyes absent homolog 3 (EYA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Benzbromarone	DMC3YUA	Gout	FA25	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[198]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[56]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[75]

Drug(s) Affected By ATP synthase subunit s, mitochondrial (DMAC2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[199]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[200]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[48]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[114]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[173]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[55]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[202]

Drug(s) Affected By Copine-1 (CPNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[203]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[203]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[68]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[46]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[172]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[172]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[40]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]

Drug(s) Affected By Suppressor of IKBKE 1 (SIKE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[114]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[101]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[130]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[56]

Drug(s) Affected By FSD1-like protein (FSD1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Bortezomib	DMNO38U	Leukemia		Approved	[47]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[114]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[55]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[101]

Drug(s) Affected By Histone-lysine N-methyltransferase SETD2 (SETD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[3]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[194]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[206]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[114]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[207]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[40]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[208]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]

Drug(s) Affected By Serine racemase (SRR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[210]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[56]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[97]

Drug(s) Affected By Mitochondrial disaggregase (CLPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[194]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[114]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[211]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]

Drug(s) Affected By 5-azacytidine-induced protein 2 (AZI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[55]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[213]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[97]

Drug(s) Affected By Ran guanine nucleotide release factor (RANGRF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[56]

Drug(s) Affected By BLOC-3 complex member HPS4 (HPS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[214]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[215]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[55]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[56]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[216]

Drug(s) Affected By Ubiquitin-like-conjugating enzyme ATG3 (ATG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[218]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[218]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[221]

Drug(s) Affected By Zinc transporter ZIP9 (SLC39A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[222]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[223]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[224]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[225]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[210]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[223]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[43]

Drug(s) Affected By tRNA:m(4)X modification enzyme TRM13 homolog (TRMT13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[68]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[121]
Haloperidol	DM96SE0	Delirium		Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[48]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]

Drug(s) Affected By SPATS2-like protein (SPATS2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[226]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]

Drug(s) Affected By Peroxisomal sarcosine oxidase (PIPOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[227]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[228]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[46]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[229]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]

Drug(s) Affected By Cilia- and flagella-associated protein 97 (CFAP97)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[230]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[100]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[55]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]

Drug(s) Affected By Ras GTPase-activating protein nGAP (RASAL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[3]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[100]

Drug(s) Affected By Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (ASAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Bortezomib	DMNO38U	Leukemia		Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[134]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[231]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[143]

Drug(s) Affected By Translocon-associated protein subunit gamma (SSR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[3]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[232]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[233]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[68]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[46]

Drug(s) Affected By Cysteinyl leukotriene receptor 1 (CYSLTR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[234]
Pranlukast	DMYHDCA	Allergic rhinitis	CA08.0	Approved	[234]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[3]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[235]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[174]
LTC4	DM702WR	Discovery agent	N.A.	Investigative	[234]
LTE4	DMCPB0Q	Discovery agent	N.A.	Investigative	[236]
BAYu9773	DMXQ14V	Discovery agent	N.A.	Investigative	[234]
CGP-57698	DMYZ72J	Discovery agent	N.A.	Investigative	[234]

Drug(s) Affected By Tubulin monoglycylase TTLL3 (TTLL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[237]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[60]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[55]

Drug(s) Affected By LHFPL tetraspan subfamily member 6 protein (LHFPL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[210]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[167]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[177]

Drug(s) Affected By Leukocyte-specific transcript 1 protein (LST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Bortezomib	DMNO38U	Leukemia		Approved	[47]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[239]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[153]
Coprexa	DMA0WEK	Neurological disorder	6B60	Phase 3	[240]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[174]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]

Drug(s) Affected By Serine/threonine-protein kinase RIO3 (RIOK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[3]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[81]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]

Drug(s) Affected By Histone deacetylase 3 (HDAC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[241]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[242]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[243]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[244]

Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[5]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[5]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[5]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[5]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[5]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[5]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[5]

Drug(s) Affected By Regulator of G-protein signaling 16 (RGS16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[245]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[196]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[15]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[97]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[245]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[247]

Drug(s) Affected By Renin (REN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[248]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[249]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[250]
Reboxetine	DM26PRD	Depression	6A70-6A7Z	Approved	[251]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[252]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[253]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[254]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[255]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[256]
Chlorthalidone	DM4DMBT	Edema	MG29	Approved	[257]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[258]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[259]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[260]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[261]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Selenium	DM25CGV	N. A.	N. A.	Approved	[263]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[264]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[265]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[266]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]

Drug(s) Affected By Glycoprotein hormones alpha chain (CGA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[268]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Octreotide	DMHIDCJ	Acromegaly	5A60.0	Approved	[269]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[270]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[271]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[105]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[272]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[273]

Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[270]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[274]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[275]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[276]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[277]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[280]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[281]

Drug(s) Affected By Interleukin-2 receptor subunit alpha (IL2RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[277]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[282]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[283]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[284]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[285]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[286]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[287]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[233]

Drug(s) Affected By T-cell surface glycoprotein CD4 (CD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[288]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[289]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[290]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[239]
Rimexolone	DMTAREC	Arthritis	FA20	Approved	[289]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[291]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[174]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]

Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[293]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[294]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[295]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[296]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[297]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[298]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[299]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[300]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[301]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[302]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[303]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[304]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[305]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[306]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[307]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[308]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[309]

Drug(s) Affected By Integrin beta-2 (ITGB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[151]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[310]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[66]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[311]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[312]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]

Drug(s) Affected By Interleukin-4 (IL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[313]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[314]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[315]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[316]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[317]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[318]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[276]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[277]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[319]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[320]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[321]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[34]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[322]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[323]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[324]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[325]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[320]

Drug(s) Affected By Lipoprotein lipase (LPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[23]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[14]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[323]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[326]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[327]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[328]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[329]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[110]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[329]

Drug(s) Affected By Cathepsin B (CTSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[330]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[331]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[332]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[333]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[334]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[335]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[336]

Drug(s) Affected By Interleukin-3 (IL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[337]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[337]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[338]
Betamethasone Valerate	DMMIAXO	Dermatological disease	DA24.Y	Approved	[339]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[313]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[140]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[339]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[23]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[23]

Drug(s) Affected By Granulocyte colony-stimulating factor (CSF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[340]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[341]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[342]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[296]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[337]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[343]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[320]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[344]

Drug(s) Affected By Fructose-bisphosphate aldolase C (ALDOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[345]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[346]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[347]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[348]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[349]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[350]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[23]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[351]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[352]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[353]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[354]

Drug(s) Affected By Breakpoint cluster region protein (BCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[355]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[66]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[356]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[357]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[233]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[358]
Bortezomib	DMNO38U	Leukemia		Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]

Drug(s) Affected By Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PPP3CB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[359]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[360]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[361]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]

Drug(s) Affected By Platelet glycoprotein 4 (CD36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[362]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[363]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[364]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[365]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[366]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[367]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[227]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[368]

Drug(s) Affected By Protein kinase C alpha type (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[369]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[370]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[110]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[371]

Drug(s) Affected By CTP synthase 1 (CTPS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[372]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[210]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[134]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[373]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[374]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[134]

Drug(s) Affected By Transcobalamin-2 (TCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[345]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[375]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[376]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[377]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[56]

Drug(s) Affected By L-serine dehydratase/L-threonine deaminase (SDS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[372]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[203]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[15]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[23]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[23]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[23]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]

Drug(s) Affected By Oxysterol-binding protein 1 (OSBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[202]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By Eukaryotic translation initiation factor 4B (EIF4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[378]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[346]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[379]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[153]

Drug(s) Affected By Insulin-like growth factor-binding protein 5 (IGFBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[14]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[380]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[381]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[218]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[382]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[383]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[23]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[384]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[385]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[386]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[387]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[388]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[389]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[390]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]

Drug(s) Affected By Serum paraoxonase/arylesterase 1 (PON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[391]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[392]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[393]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[394]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[395]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[396]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[397]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[398]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[391]

Drug(s) Affected By Glutathione S-transferase Mu 2 (GSTM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[331]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[96]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[46]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[399]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[400]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[401]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]

Drug(s) Affected By Interleukin-12 subunit beta (IL12B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[274]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[402]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[337]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[403]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[404]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[405]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[406]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[407]
Bryostatin-1	DM1JOXY	Alzheimer disease	8A20	Phase 2	[408]

Drug(s) Affected By Protein EVI2B (EVI2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[409]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[410]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[140]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[182]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[411]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[412]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[97]

Drug(s) Affected By Interleukin-13 (IL13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[413]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[414]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[415]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[342]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[281]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[416]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[417]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[342]
Ethambutol	DMR87LC	Pulmonary tuberculosis	1B10.Z	Approved	[281]

Drug(s) Affected By Insulin receptor substrate 1 (IRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[260]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[66]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[171]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[418]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[111]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[419]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[420]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[421]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[422]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[423]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[424]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[425]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[426]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[427]

Drug(s) Affected By Interleukin-6 receptor subunit beta (IL6ST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[385]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[428]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[429]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[430]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[430]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[96]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[23]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[385]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[431]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[432]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[433]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[434]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[435]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[436]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[437]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[438]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[68]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[68]
Bortezomib	DMNO38U	Leukemia		Approved	[47]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[153]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[55]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[97]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[439]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[440]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[441]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[304]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[442]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[443]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[444]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[445]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[446]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[384]

Drug(s) Affected By Tyrosine-protein kinase ABL2 (ABL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[447]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[134]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[128]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[62]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[134]

Drug(s) Affected By Translocon-associated protein subunit alpha (SSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1C (CDKN1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[448]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[355]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[449]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[449]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[171]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[47]

Drug(s) Affected By Thiopurine S-methyltransferase (TPMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[23]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[450]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[451]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[452]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[453]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[48]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[454]
Bendroflumethiazide	DM7EVLC	High blood pressure	BA00	Approved	[455]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By Neuronal membrane glycoprotein M6-a (GPM6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[456]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[183]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[115]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[173]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[457]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[75]

Drug(s) Affected By F-actin-capping protein subunit alpha-1 (CAPZA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[409]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[458]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[377]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[459]

Drug(s) Affected By Calcipressin-1 (RCAN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[460]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[96]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[360]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[172]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[172]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[460]

Drug(s) Affected By Heat shock-related 70 kDa protein 2 (HSPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[381]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[461]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[462]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]

Drug(s) Affected By Eukaryotic translation initiation factor 5 (EIF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[463]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[66]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[133]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[464]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit E (EIF3E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[55]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[465]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[216]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[65]

Drug(s) Affected By Actin-related protein 3 (ACTR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[203]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[68]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[68]

Drug(s) Affected By Actin-related protein 2 (ACTR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[466]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[130]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[467]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[75]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[65]

Drug(s) Affected By Somatostatin (SST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[380]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[268]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Octreotide	DMHIDCJ	Acromegaly	5A60.0	Approved	[468]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[176]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[469]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[380]

Drug(s) Affected By Nuclear transport factor 2 (NUTF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[153]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[40]

Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (GNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[470]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[471]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[472]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[456]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[114]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[386]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[473]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[474]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[346]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[475]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[476]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[456]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[477]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]

Drug(s) Affected By Forkhead box protein K2 (FOXK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[478]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[97]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[338]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[230]

Drug(s) Affected By Histone-lysine N-methyltransferase MECOM (MECOM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[66]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[70]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]

Drug(s) Affected By Caveolin-1 (CAV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[354]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[14]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[479]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[480]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[481]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[482]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[483]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[385]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[354]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[484]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[27]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[390]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[485]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[486]

Drug(s) Affected By Hormone-sensitive lipase (LIPE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[487]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[488]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[487]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[227]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[489]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[176]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[490]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
CS-038	DM67P0F	Type-2 diabetes	5A11	Phase 3	[489]

Drug(s) Affected By Glutamine--fructose-6-phosphate aminotransferase 1 (GFPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-glutamine	DM69G8X	Short bowel syndrome	KB89.1	Approved	[23]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[171]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[70]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]

Drug(s) Affected By TNF receptor-associated factor 1 (TRAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[155]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[491]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[66]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[492]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[15]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[97]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[493]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[338]

Drug(s) Affected By Histone deacetylase 1 (HDAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[470]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[494]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[232]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[495]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[227]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[496]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[46]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit A (EIF3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[497]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[97]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[134]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[498]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[168]

Drug(s) Affected By Indian hedgehog protein (IHH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[50]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[499]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[500]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[500]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
CHIR-99021	DMB8MNU	Allergic inflammation	4A80-4A85	Patented	[501]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[502]

Drug(s) Affected By Astrocytic phosphoprotein PEA-15 (PEA15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]

Drug(s) Affected By Transcription initiation factor TFIID subunit 7 (TAF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[228]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[81]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[503]

Drug(s) Affected By Dual specificity testis-specific protein kinase 1 (TESK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[64]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[62]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[55]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[56]

Drug(s) Affected By Homeobox protein TGIF1 (TGIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[504]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[409]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[505]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[126]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]

Drug(s) Affected By Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[70]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[506]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[200]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[46]

Drug(s) Affected By Leukotriene C4 synthase (LTC4S)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[507]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[508]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[128]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[509]
Pranlukast	DMYHDCA	Allergic rhinitis	CA08.0	Approved	[510]
Etazolate	DMOCID7	Neurodegenerative disorder	8A20-8A23	Phase 2	[2]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[2]
ROLIPRAM	DMJ03UM	Discovery agent	N.A.	Investigative	[2]

Drug(s) Affected By Transcription elongation factor SPT6 (SUPT6H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[55]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[377]

Drug(s) Affected By 5'-3' exonuclease PLD3 (PLD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[372]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[176]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[511]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[140]

Drug(s) Affected By B-cell linker protein (BLNK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[512]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[104]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[56]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[97]

Drug(s) Affected By Histone deacetylase 2 (HDAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[513]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[514]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[515]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[495]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[516]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[53]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[517]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[518]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]

Drug(s) Affected By Proprotein convertase subtilisin/kexin type 5 (PCSK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[262]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[140]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[183]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[115]

Drug(s) Affected By Sodium/iodide cotransporter (SLC5A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[335]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[519]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[520]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[521]
Tazarotene	DM8SMD1	Acne vulgaris	ED80	Approved	[522]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[522]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[522]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[523]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[524]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[522]

Drug(s) Affected By Interferon regulatory factor 7 (IRF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[525]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[320]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[526]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[96]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[527]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[112]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[320]

Drug(s) Affected By Protein tyrosine phosphatase type IVA 1 (PTP4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[245]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[528]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[111]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[97]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[176]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[48]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[245]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[529]

Drug(s) Affected By E3 ubiquitin-protein ligase NEDD4-like (NEDD4L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[171]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[210]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[530]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[167]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[531]

Drug(s) Affected By Cell cycle checkpoint control protein RAD9A (RAD9A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[532]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[533]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[534]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[535]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[536]
taurine	DMVW7N3	Discovery agent	N.A.	Investigative	[537]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[538]

Drug(s) Affected By BTB/POZ domain-containing protein 10 (BTBD10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[55]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[377]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[97]

Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[539]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[5]
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[5]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[5]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[5]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[5]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[5]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[5]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[5]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[5]

Drug(s) Affected By Mucin-5B (MUC5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[540]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[541]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[542]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[83]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]

Drug(s) Affected By Neurexin-3-beta (NRXN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[130]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[543]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[544]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[173]

Drug(s) Affected By Alpha-1-antitrypsin (SERPINA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[545]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[546]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[15]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[547]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]

Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[548]
Ademetionine	DMYQDBO	Hepatic fibrosis	DB93.0	Approved	[549]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[23]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[550]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[551]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[103]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[552]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[23]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[553]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[554]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[554]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[554]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[555]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[556]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[557]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[558]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[559]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[560]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[23]

Drug(s) Affected By Interferon alpha-1/13 (IFNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[280]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[561]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[562]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[125]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Ecto-5'-nucleotidase (CD73)	TTK0O6Y	5NTD_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5'-3' exonuclease PLD3 (PLD3)	OTL07SP2	PLD3_HUMAN	Gene/Protein Processing	[2]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)	OT7TNF0L	AAPK1_HUMAN	Gene/Protein Processing	[3]
5-azacytidine-induced protein 2 (AZI2)	OT61Q7Q8	AZI2_HUMAN	Gene/Protein Processing	[3]
5-methylcytosine rRNA methyltransferase NSUN4 (NSUN4)	OTY6O37Z	NSUN4_HUMAN	Gene/Protein Processing	[3]
Actin-related protein 2 (ACTR2)	OT3C8U5T	ARP2_HUMAN	Gene/Protein Processing	[2]
Actin-related protein 3 (ACTR3)	OT05LJSH	ARP3_HUMAN	Gene/Protein Processing	[2]
Adenosine deaminase domain-containing protein 1 (ADAD1)	OTXRDF3Z	ADAD1_HUMAN	Gene/Protein Processing	[3]
Allergin-1 (MILR1)	OT0O30C7	MILR1_HUMAN	Gene/Protein Processing	[3]
Alpha-1-antitrypsin (SERPINA1)	OTACYW9J	A1AT_HUMAN	Drug Response	[4]
Angiotensin-converting enzyme 2 (ACE2)	OTTRZGU7	ACE2_HUMAN	Gene/Protein Processing	[5]

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