Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6CHNJ)

• Drug Name: Camptothecin Drug Info
• Synonyms: camptothecin; Camptothecine; 7689-03-4; (S)-(+)-Camptothecin; Campathecin; d-Camptothecin; (+)-Camptothecine; (+)-Camptothecin; 20(S)-Camptothecine; 21,22-Secocamptothecin-21-oic acid lactone; NSC94600; (S)-Camptothecin; Camptothecine (8CI); 20(S)-Camptothecin; Camptothecine (S,+); CHEMBL65; UNII-XT3Z54Z28A; MLS000766223; (4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; XT3Z54Z28A; CHEBI:27656; VSJKWCGYPAHWDS-FQEVSTJZSA-N; Camptothecin, Camptotheca acuminata; NSC-94600; Camptothecin derivat

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 3	[1]

• Cross-matching ID:
  PubChem CID: 24360
  ChEBI ID: CHEBI:27656
  CAS Number: CAS 7689-03-4
  TTD Drug ID: DM6CHNJ
  VARIDT Drug ID: DR01383

Molecule-Related Drug Atlas

Drug(s) Targeting DNA topoisomerase I (TOP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[10]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[10]
B-Lactams	DMR8YD6	Bacterial infection	1A00-1C4Z	Approved	[11]
Belotecan hydrocholoride	DM3SRJZ	Small-cell lung cancer	2C25.Y	Approved	[12]
Topetecan	DMAE6LK	Small-cell lung cancer	2C25.Y	Approved	[13]
Karenitecin	DMCRGY4	Lung cancer	2C25.0	Phase 3	[14]
Exatecan	DMCA7FN	Solid tumour/cancer	2A00-2F9Z	Phase 3	[15]
Edotecarin	DM3ZL7D	Gastric adenocarcinoma	2B72	Phase 3	[16]
Rubitecan	DMDWU1S	Human immunodeficiency virus infection	1C62	Phase 3	[17]
Etirinotecan pegol	DMQHX1Y	Breast cancer	2C60-2C65	Phase 3	[18]

Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[19]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[20]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[21]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[22]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[25]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[26]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[27]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[28]

Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[29]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[31]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[33]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[34]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[35]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[34]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[36]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[37]

Drug(s) Transported By Multidrug resistance-associated protein 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[38]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[39]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[40]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[41]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[3]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[42]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[43]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[45]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[3]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[46]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[48]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[48]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[49]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[50]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[53]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[54]

Drug(s) Affected By Dihydropyrimidine dehydrogenase (DPYD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[55]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[56]
Tegafur	DM31ZQM	Solid tumour/cancer	2A00-2F9Z	Approved	[57]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[58]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]

Drug(s) Affected By Frataxin, mitochondrial (FXN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Molsidomine	DM9MA8O	Angina pectoris	BA40	Approved	[65]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Deferiprone	DMS2M7O	Beta thalassemia	3A50.2	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[70]

Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[71]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[77]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[78]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[79]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[80]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[81]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[82]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[83]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[84]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[85]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[86]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[84]

Drug(s) Affected By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[87]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[88]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[87]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[88]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[89]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[87]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[87]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[87]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[90]
Dabrafenib	DMX6OE3	Melanoma	2C30	Approved	[91]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[92]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[93]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[94]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[95]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[96]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[97]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[98]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[99]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[100]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[101]

Drug(s) Affected By Transcription factor SOX-12 (SOX12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[109]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[111]
Haloperidol	DM96SE0	Delirium		Approved	[58]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[112]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[113]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[115]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[116]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[117]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[119]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[123]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[125]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]

Drug(s) Affected By Retinoic acid receptor alpha (RARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[112]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[129]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[130]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[130]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[130]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[133]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Selenium	DM25CGV	N. A.	N. A.	Approved	[137]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[138]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[139]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[141]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[142]

Drug(s) Affected By Adenomatous polyposis coli protein (APC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[147]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[148]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[149]

Drug(s) Affected By Transcription factor SOX-11 (SOX11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[153]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[153]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[154]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[155]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[150]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Activin receptor type-1B (ACVR1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[157]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[158]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[159]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[160]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[161]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[162]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[155]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[160]

Drug(s) Affected By Transcription factor SOX-3 (SOX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[164]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[165]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[166]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[150]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Transcription factor SOX-8 (SOX8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[105]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]

Drug(s) Affected By Caveolin-1 (CAV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[170]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[171]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[172]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[173]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]

Drug(s) Affected By Transcription factor SOX-4 (SOX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[178]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[179]

Drug(s) Affected By Centrosomal protein of 85 kDa-like (CEP85L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[180]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[162]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[109]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[150]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[150]

Drug(s) Affected By Centrosome-associated protein ALMS1 (ALMS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[180]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[182]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[105]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[168]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[184]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]

Drug(s) Affected By AMSH-like protease (STAMBPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[180]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[186]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[162]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]

Drug(s) Affected By Frizzled-8 (FZD8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[188]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[162]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[189]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[146]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[150]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[150]

Drug(s) Affected By Transcription factor SOX-17 (SOX17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[188]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[188]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[188]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[190]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[191]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[188]
Ziprasidone	DMM58JY	Bipolar disorder	6A60	Approved	[188]

Drug(s) Affected By Frizzled-1 (FZD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[192]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[192]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[194]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[192]

Drug(s) Affected By Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[153]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[153]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[196]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[162]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[155]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[109]

Drug(s) Affected By Transcription factor E2F8 (E2F8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[198]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[76]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[180]

Drug(s) Affected By Transmembrane protein 250 (TMEM250)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[6]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[6]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[6]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[195]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[201]

Drug(s) Affected By Agrin (AGRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[130]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[202]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[203]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[204]

Drug(s) Affected By Etoposide-induced protein 2.4 homolog (EI24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[198]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[205]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[148]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[8]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[8]

Drug(s) Affected By Telomerase reverse transcriptase (TERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[206]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[207]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Selenium	DM25CGV	N. A.	N. A.	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[212]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[75]

Drug(s) Affected By Tax1-binding protein 3 (TAX1BP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[8]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[8]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[214]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[215]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[216]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[217]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[218]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[219]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[220]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[221]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[222]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[223]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[224]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[225]

Drug(s) Affected By SLIT-ROBO Rho GTPase-activating protein 3 (SRGAP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[6]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[191]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[226]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[227]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[165]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[226]

Drug(s) Affected By Histone-lysine N-methyltransferase SUV39H1 (SUV39H1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[76]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[230]
Bortezomib	DMNO38U	Leukemia		Approved	[231]

Drug(s) Affected By Cytoplasmic protein NCK2 (NCK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[8]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[8]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[109]

Drug(s) Affected By Protein regulator of cytokinesis 1 (PRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[76]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[130]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]

Drug(s) Affected By A-kinase anchor protein 8 (AKAP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[196]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[215]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[232]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[233]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[234]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[195]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[235]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[237]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[239]

Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[240]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[242]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[243]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[245]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[243]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[247]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[248]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[249]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[250]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[251]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Selenium	DM25CGV	N. A.	N. A.	Approved	[252]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[253]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[254]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[255]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[256]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[162]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[58]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[257]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[258]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[259]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[260]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[261]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[262]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[264]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[249]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[265]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[267]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[268]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[270]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[271]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[272]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[273]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[274]
Fructose	DM43AN2	Vomiting	MD90	Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[275]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[276]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[249]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[113]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[277]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[278]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[279]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[280]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[281]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[282]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[283]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[254]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[284]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[285]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[286]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[287]

Drug(s) Affected By DNA excision repair protein ERCC-1 (ERCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[288]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[289]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[290]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[291]

Drug(s) Affected By Thrombospondin-1 (THBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[256]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[294]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[295]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[122]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[295]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[296]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]

Drug(s) Affected By Transcription factor Sp1 (SP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[297]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[298]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[299]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[300]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[301]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[302]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[303]

Drug(s) Affected By Interleukin-6 receptor subunit alpha (IL6R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[304]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[305]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[306]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[307]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[308]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[290]

Drug(s) Affected By Galectin-1 (LGALS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[309]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[310]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[311]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[312]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[313]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[314]

Drug(s) Affected By Annexin A4 (ANXA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[315]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[316]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[204]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[317]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[318]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[219]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[319]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[320]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[319]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[139]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[321]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[322]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[323]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[324]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[325]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[326]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[276]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[327]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[328]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[329]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[328]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[330]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[331]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[332]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[333]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[334]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[335]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[336]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[170]

Drug(s) Affected By Microtubule-associated protein tau (MAPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[337]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[338]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[339]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[340]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[341]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[179]

Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[342]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[268]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[343]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[311]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[307]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[307]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[180]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[344]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[345]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[346]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[347]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[348]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[256]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[349]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[350]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[113]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[351]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[352]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[256]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[353]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[354]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[343]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[355]

Drug(s) Affected By Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[356]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[198]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[125]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[341]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[357]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[113]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Selenium	DM25CGV	N. A.	N. A.	Approved	[252]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[220]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[320]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[358]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[221]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[197]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[359]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[360]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[361]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[362]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[363]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[364]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[365]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[366]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[367]

Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[368]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[310]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[369]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[370]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[371]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[372]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[373]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[374]

Drug(s) Affected By Syndecan-1 (SDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[192]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[375]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[341]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[191]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[376]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[249]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[377]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[221]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[270]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[378]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[243]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[379]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[380]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[381]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[357]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[250]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[382]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[383]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[284]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[197]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[293]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[384]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]

Drug(s) Affected By NADPH:adrenodoxin oxidoreductase, mitochondrial (FDXR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[382]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[192]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[180]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[8]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[8]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[385]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[386]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[249]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[235]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[387]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[221]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[388]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[389]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[390]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[391]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[392]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[393]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[383]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[320]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[284]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[394]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[267]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[395]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[396]

Drug(s) Affected By Retinoblastoma-like protein 1 (RBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[397]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[398]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[399]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[400]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[401]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[402]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[170]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[403]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[404]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[405]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[260]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[253]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[386]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[406]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[249]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[377]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[407]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[382]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[408]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[409]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]

Drug(s) Affected By Coilin (COIL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[162]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[109]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[233]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[410]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[411]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[113]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[217]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[283]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[382]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[220]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[412]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[320]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[192]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 9 (TNFSF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[192]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[256]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[389]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[389]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[413]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[414]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[415]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[416]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[240]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[417]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[253]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[418]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[419]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[420]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[421]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[422]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[423]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[424]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[425]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[426]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[427]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[428]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[429]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[430]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[431]

Drug(s) Affected By Caspase-2 (CASP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[335]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[432]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[398]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[433]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[434]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[413]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[435]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[436]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[437]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[275]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[278]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[271]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[438]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[278]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[439]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[275]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[278]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[440]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[441]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[278]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[442]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[443]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[398]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[420]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[444]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]

Drug(s) Affected By Double-strand break repair protein MRE11 (MRE11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[445]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[446]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[447]

Drug(s) Affected By Breast cancer type 2 susceptibility protein (BRCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[381]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[390]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[448]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[180]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[249]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[449]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[450]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[451]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[451]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[452]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[453]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[366]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[436]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[454]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[335]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[455]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[456]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[219]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[457]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[458]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[459]

Drug(s) Affected By Hepcidin (HAMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[460]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[461]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[462]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[463]
Papaverine	DMCA9QP	Brain ischaemia	8B1Z	Approved	[463]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[464]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[465]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[466]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[317]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[455]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[467]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[450]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[256]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[468]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[469]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[465]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[470]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[470]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[471]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[472]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[473]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[474]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[205]

Drug(s) Affected By Transcription factor Sp3 (SP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[297]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[303]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[475]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[476]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[477]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[478]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]

Drug(s) Affected By Antigen peptide transporter 1 (TAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[389]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[389]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[375]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[180]

Drug(s) Affected By CCAAT/enhancer-binding protein zeta (CEBPZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[8]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[8]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[150]

Drug(s) Affected By DNA repair protein RAD51 homolog 1 (RAD51)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[216]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[479]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[480]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[76]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[481]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[76]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[330]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[431]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[334]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[112]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[455]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[283]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[482]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[320]

Drug(s) Affected By Histone acetyltransferase p300 (EP300)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[483]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[484]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[148]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[316]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[485]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]

Drug(s) Affected By Unconventional myosin-Ie (MYO1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[6]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[6]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[6]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[6]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[196]

Drug(s) Affected By Vesicle transport protein SEC20 (BNIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[6]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[6]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[486]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[486]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[487]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[488]

Drug(s) Affected By Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[216]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[489]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[490]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]

Drug(s) Affected By Transcription intermediary factor 1-beta (TRIM28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[491]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[492]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[234]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Haloperidol	DM96SE0	Delirium		Approved	[491]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[491]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[491]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[493]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[494]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[495]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[220]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[496]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[497]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[474]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[498]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[499]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[415]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[416]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[500]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[501]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[502]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[221]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[503]

Drug(s) Affected By Beclin-1 (BECN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[504]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[417]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[242]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[505]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[506]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[507]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[508]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[509]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[510]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[511]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[512]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[465]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[513]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[514]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[219]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[458]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[256]

Drug(s) Affected By Cyclin-dependent kinase 5 activator 1 (CDK5R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[337]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[515]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[6]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[516]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[49]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[49]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[517]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[518]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[249]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[519]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[520]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[521]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[522]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[523]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[524]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[525]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[526]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[527]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[246]

Drug(s) Affected By Quinone oxidoreductase PIG3 (TP53I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[219]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[528]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[529]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[205]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[530]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[130]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[130]

Drug(s) Affected By EPM2A-interacting protein 1 (EPM2AIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[8]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[8]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[196]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[162]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[531]

Drug(s) Affected By tRNA-uridine aminocarboxypropyltransferase 1 (DTWD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[6]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[162]

Drug(s) Affected By TBC1 domain family member 16 (TBC1D16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[532]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[191]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[196]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[6]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[531]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[533]

Drug(s) Affected By Protein Jumonji (JARID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[277]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[534]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[6]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[167]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]

Drug(s) Affected By DNA repair protein RAD50 (RAD50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[277]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[315]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[342]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[413]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[179]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[535]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[536]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[537]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[499]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[538]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[539]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[540]

Drug(s) Affected By Small glutamine-rich tetratricopeptide repeat-containing protein beta (SGTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[541]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[146]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[109]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[542]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 5 (MAP3K5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[543]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[544]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[545]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[444]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[546]

Drug(s) Affected By Tumor protein 63 (TP63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[528]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[547]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[548]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[341]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[549]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]

Drug(s) Affected By Serine/threonine-protein kinase PLK3 (PLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[130]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[550]

Drug(s) Affected By Sphingomyelin phosphodiesterase 3 (SMPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[551]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[478]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[478]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[166]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[109]

Drug(s) Affected By PH and SEC7 domain-containing protein 3 (PSD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[375]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[180]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[149]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[385]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[552]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[249]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[407]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[407]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[553]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[407]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[270]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[378]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[379]

Drug(s) Affected By Kelch-like protein 42 (KLHL42)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[6]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[6]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[186]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[162]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[155]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[109]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[155]

Drug(s) Affected By Calcium-binding protein 39 (CAB39)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[8]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[8]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[554]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[199]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[555]

Drug(s) Affected By RWD domain-containing protein 3 (RWDD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[556]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[6]
Pracinostat	DMTD7AB	Acute myeloid leukaemia	2A60	Phase 3	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[557]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[465]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[327]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[558]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[328]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[328]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[559]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[560]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[561]

Drug(s) Affected By Integrin-binding sialoprotein (IBSP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[562]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[563]
Calcidiol	DMN4CV5	Hypophosphatemia		Approved	[562]
Magnesium	DMU4ORS	Ischemic stroke	8B11.5Z	Approved	[564]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[565]
GSK2816126	DMJDVW4	Solid tumour/cancer	2A00-2F9Z	Phase 1	[566]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[567]
alpha-ketoglutaric acid	DM5LFYN	Discovery agent	N.A.	Investigative	[568]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF31 (RNF31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[569]

Drug(s) Affected By Survival motor neuron protein (SMN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[570]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[570]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[196]
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[570]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[571]

Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[572]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[495]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[573]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[390]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[574]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]

Drug(s) Affected By Agouti-related protein (AGRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[196]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[533]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PPP2R5E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[162]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[575]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[554]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[234]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[234]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[180]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[149]
Bortezomib	DMNO38U	Leukemia		Approved	[576]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[160]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[577]

Drug(s) Affected By Cytochrome P450 26B1 (CYP26B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[578]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[178]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[579]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[159]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[153]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[196]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[164]

Drug(s) Affected By Tumor susceptibility gene 101 protein (TSG101)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[489]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[580]
4-hydroxy-2-nonenal	DM2LJFZ	Discovery agent	N.A.	Investigative	[51]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[195]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[581]

Drug(s) Affected By TNF receptor-associated factor 6 (TRAF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[582]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[413]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[221]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[583]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[584]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[148]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[585]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[586]

Drug(s) Affected By Retinoblastoma-like protein 2 (RBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[587]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[588]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[179]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[589]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[148]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]

Drug(s) Affected By Protein sel-1 homolog 1 (SEL1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[590]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[591]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[316]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[592]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[155]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[146]

Drug(s) Affected By Protein prenyltransferase alpha subunit repeat-containing protein 1 (PTAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[109]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[557]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[593]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[199]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[150]

Drug(s) Affected By Lipid scramblase CLPTM1L (CLPTM1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[196]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[594]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[557]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[595]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[596]

Drug(s) Affected By Caspase-10 (CASP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[597]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[219]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[398]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[598]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[342]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[599]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[158]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[160]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[196]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[160]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[600]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[575]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[184]

Drug(s) Affected By DNA repair endonuclease XPF (ERCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[413]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[601]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[602]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[603]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Bortezomib	DMNO38U	Leukemia		Approved	[604]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[605]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase O (PTPRO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[606]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[150]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[52]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[607]

Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[608]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[609]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[610]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[611]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[612]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[613]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[614]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[615]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[616]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[616]

Drug(s) Affected By Serine/threonine-protein kinase ATR (ATR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[474]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[617]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[618]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[619]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[369]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[474]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[620]

Drug(s) Affected By Cone-rod homeobox protein (CRX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[621]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[622]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[191]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[613]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[153]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[623]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[256]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[473]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[624]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[425]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[625]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[626]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[402]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[627]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[628]

Drug(s) Affected By Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[629]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[196]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[630]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[109]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[631]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[234]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[234]

Drug(s) Affected By Diacylglycerol kinase zeta (DGKZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[309]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[632]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[556]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[234]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[633]
taurine	DMVW7N3	Discovery agent	N.A.	Investigative	[634]

Drug(s) Affected By Homeobox protein Hox-A1 (HOXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[635]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[180]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[636]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[637]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[146]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[166]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[600]

Drug(s) Affected By Myotubularin-related protein 2 (MTMR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[638]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[233]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[234]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[234]

Drug(s) Affected By Neural cell adhesion molecule 1 (NCAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[639]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[584]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[640]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[155]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[641]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Olfactory receptor 7C2 (OR7C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By A-kinase anchor protein 13 (AKAP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[385]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[642]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[643]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[644]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]

Drug(s) Affected By TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (TAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[576]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[196]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[109]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[557]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[234]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[643]

Drug(s) Affected By ARF GTPase-activating protein GIT2 (GIT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[160]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[162]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[160]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[645]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[234]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[593]

Drug(s) Affected By Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[646]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[647]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[648]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[649]
Trabectedin	DMG3Y89	Leiomyosarcoma	2B58	Approved	[650]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[402]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[651]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[219]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[652]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[470]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[653]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[342]

Drug(s) Affected By MTRF1L release factor glutamine methyltransferase (HEMK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[109]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[557]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[654]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 1B (PPP1R1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[191]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[556]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[166]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[655]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[655]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[655]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[150]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[556]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[607]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Serine/threonine/tyrosine-interacting-like protein 1 (STYXL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[398]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[109]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[52]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[596]

Drug(s) Affected By Apoptosis-inducing factor 3 (AIFM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[109]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[656]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[607]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[656]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[306]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[382]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[285]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[574]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[163]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[657]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[658]

Drug(s) Affected By DNA repair protein RAD51 homolog 3 (RAD51C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[192]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[659]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[624]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[624]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[465]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[170]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[573]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[660]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[661]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[662]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[663]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 7 (MAP3K7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[415]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[664]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[452]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[180]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[665]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[160]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[160]

Drug(s) Affected By Olfactory receptor 1A2 (OR1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[196]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Potassium channel subfamily K member 2 (KCNK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[666]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[184]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[607]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[195]

Drug(s) Affected By Artemin (ARTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[161]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[667]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[630]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[166]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[667]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[668]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[485]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[640]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[52]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[557]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[669]

Drug(s) Affected By Protein phosphatase 1 regulatory inhibitor subunit 16B (PPP1R16B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[198]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[196]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[166]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[670]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[669]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[195]
taurine	DMVW7N3	Discovery agent	N.A.	Investigative	[634]

Drug(s) Affected By Ataxin-3-like protein (ATXN3L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA topoisomerase I (TOP1)	TTGTQHC	TOP1_HUMAN	Modulator	[1]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[2]
Multidrug resistance-associated protein 4 (ABCC4)	DTCSGPB	MRP4_HUMAN	Substrate	[3]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
A-kinase anchor protein 13 (AKAP13)	OTOZAR14	AKP13_HUMAN	Drug Response	[5]
A-kinase anchor protein 8 (AKAP8)	OTK3EQAI	AKAP8_HUMAN	Gene/Protein Processing	[6]
Activin receptor type-1B (ACVR1B)	OT778HIQ	ACV1B_HUMAN	Post-Translational Modifications	[7]
Adenomatous polyposis coli protein (APC)	OTKV0TIK	APC_HUMAN	Post-Translational Modifications	[7]
Agouti-related protein (AGRP)	OT7XRHWU	AGRP_HUMAN	Drug Response	[5]
Agrin (AGRN)	OTWJENAZ	AGRIN_HUMAN	Gene/Protein Processing	[8]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[9]
AMSH-like protease (STAMBPL1)	OTI4CYTF	STALP_HUMAN	Post-Translational Modifications	[7]
Annexin A4 (ANXA4)	OTUCRYXL	ANXA4_HUMAN	Gene/Protein Processing	[8]
Antigen peptide transporter 1 (TAP1)	OTJL27PW	TAP1_HUMAN	Gene/Protein Processing	[8]

References

• [1] Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer. 2006 Oct;6(10):789-802.
• [2] Pharmacogenetics of membrane transporters: an update on current approaches. Mol Biotechnol. 2010 Feb;44(2):152-67.
• [3] Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
• [4] The beta-carboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin in breast cancer cells. Phytother Res. 2010 Jan;24(1):146-9.
• [5] ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses. Cancer Res. 2014 Dec 1;74(23):6968-79.
• [6] Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
• [7] Reduced camptothecin sensitivity of estrogen receptor-positive human breast cancer cells following exposure to di(2-ethylhexyl)phthalate (DEHP) is associated with DNA methylation changes. Environ Toxicol. 2019 Apr;34(4):401-414.
• [8] Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling. Mutat Res. 2007 Jun 1;619(1-2):16-29. doi: 10.1016/j.mrfmmm.2006.12.007. Epub 2007 Feb 8.
• [9] Albumin-binding prodrugs of camptothecin and doxorubicin with an Ala-Leu-Ala-Leu-linker that are cleaved by cathepsin B: synthesis and antitumor efficacy. Bioconjug Chem. 2007 May-Jun;18(3):702-16. doi: 10.1021/bc0602735. Epub 2007 Mar 23.
• [10] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [11] Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I. Biochem J. 2002 Sep 1;366(Pt 2):653-61.
• [12] Impact of natural products on developing new anti-cancer agents. Chem Rev. 2009 Jul;109(7):3012-43.
• [13] Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
• [14] Characterization of protein kinase chk1 essential for the cell cycle checkpoint after exposure of human head and neck carcinoma A253 cells to a novel topoisomerase I inhibitor BNP1350. Mol Pharmacol.2000 Mar;57(3):453-9.
• [15] Phase I study of topoisomerase I inhibitor exatecan mesylate (DX-8951f) given as weekly 24-hour infusions three of every four weeks. Clin Cancer Res. 2001 Dec;7(12):3963-70.
• [16] Edotecarin: a novel topoisomerase I inhibitor. Clin Colorectal Cancer. 2005 May;5(1):27-36.
• [17] Rubitecan. Expert Opin Investig Drugs. 2006 Jan;15(1):71-9.
• [18] Nonclinical pharmacokinetics and activity of etirinotecan pegol (NKTR-102), a long-acting topoisomerase 1 inhibitor, in multiple cancer models. Cancer Chemother Pharmacol. 2014 Dec;74(6):1125-37.
• [19] Involvement of the drug transporters p glycoprotein and multidrug resistance-associated protein Mrp2 in telithromycin transport. Antimicrob Agents Chemother. 2006 Jan;50(1):80-7.
• [20] Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine models. Drug Metab Dispos. 2011 Nov;39(11):2155-61.
• [21] Mammalian multidrug-resistance proteins (MRPs). Essays Biochem. 2011 Sep 7;50(1):179-207.
• [22] Enhancing chemosensitivity in oral squamous cell carcinoma by lentivirus vector-mediated RNA interference targeting EGFR and MRP2. Oncol Lett. 2016 Sep;12(3):2107-2114.
• [23] Multidrug resistance associated protein 2 mediates transport of prostaglandin E2. Liver Int. 2006 Apr;26(3):362-8.
• [24] Lentivirus-mediated RNAi silencing targeting ABCC2 increasing the sensitivity of a human nasopharyngeal carcinoma cell line against cisplatin. J Transl Med. 2008 Oct 4;6:55.
• [25] Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein. Biochem Pharmacol. 2004 Aug 15;68(4):791-8.
• [26] Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G371-7.
• [27] Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab Dispos. 2002 Apr;30(4):457-63.
• [28] Multidrug Resistance-Associated Protein 2 (MRP2) Mediated Transport of Oxaliplatin-Derived Platinum in Membrane Vesicles. PLoS One. 2015 Jul 1;10(7):e0130727.
• [29] Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25.
• [30] Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003 Sep 1;63(17):5538-43.
• [31] The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9.
• [32] Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10.
• [33] Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93.
• [34] Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51.
• [35] The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Lett. 2016 Jun 28;376(1):165-72.
• [36] Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res. 2009 Feb;26(2):480-7.
• [37] Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood. 2004 Nov 1;104(9):2940-2.
• [38] Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport. J Pharmacol Exp Ther. 2007 Jan;320(1):229-35.
• [39] Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 2002 Jun 1;62(11):3144-50.
• [40] ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44.
• [41] The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9.
• [42] Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J. 2003 Apr 15;371(Pt 2):361-7.
• [43] P-glycoprotein, but not multidrug resistance protein 4, plays a role in the systemic clearance of irinotecan and SN-38 in mice. Drug Metab Lett. 2010 Dec;4(4):195-201.
• [44] Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia. Blood. 2009 Aug 13;114(7):1383-6.
• [45] Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues. Biochem J. 2002 Feb 1;361(Pt 3):497-503.
• [46] Influence of glutathione S-transferase A1, P1, M1, T1 polymorphisms on oral busulfan pharmacokinetics in children with congenital hemoglobinopathies undergoing hematopoietic stem cell transplantation. Pediatr Blood Cancer. 2010 Dec 1;55(6):1172-9. doi: 10.1002/pbc.22739.
• [47] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [48] The influence of coordinate overexpression of glutathione phase II detoxification gene products on drug resistance. J Pharmacol Exp Ther. 2000 Aug;294(2):480-7.
• [49] Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Res. 2004 Jun 15;64(12):4218-26.
• [50] Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
• [51] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
• [52] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [53] Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
• [54] Glutathione S-transferase pi as a target for tricyclic antidepressants in human brain. Acta Biochim Pol. 2004;51(1):207-12.
• [55] Heterozygosity for a point mutation in an invariant splice donor site of dihydropyrimidine dehydrogenase and severe 5-fluorouracil related toxicity. Eur J Cancer. 1997 Nov;33(13):2258-64. doi: 10.1016/s0959-8049(97)00261-x.
• [56] DPD is a molecular determinant of capecitabine efficacy in colorectal cancer. Int J Oncol. 2007 Aug;31(2):413-8.
• [57] Dihydropyrimidine dehydrogenases and cytidine-deaminase gene polymorphisms as outcome predictors in resected gastric cancer patients treated with fluoropyrimidine adjuvant chemotherapy. J Surg Oncol. 2008 Aug 1;98(2):130-4.
• [58] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [59] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [60] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [61] Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
• [62] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [63] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [64] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [65] Pharmacological screening using an FXN-EGFP cellular genomic reporter assay for the therapy of Friedreich ataxia. PLoS One. 2013;8(2):e55940.
• [66] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [67] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [68] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [69] Oxidative stress-dependent frataxin inhibition mediated alcoholic hepatocytotoxicity through ferroptosis. Toxicology. 2020 Dec 1;445:152584. doi: 10.1016/j.tox.2020.152584. Epub 2020 Oct 2.
• [70] Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
• [71] Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil. PLoS One. 2011;6(12):e28862. doi: 10.1371/journal.pone.0028862. Epub 2011 Dec 15.
• [72] Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
• [73] Direct activation of ATM by resveratrol under oxidizing conditions. PLoS One. 2014 Jun 16;9(6):e97969. doi: 10.1371/journal.pone.0097969. eCollection 2014.
• [74] Long-term exposure to zidovudine delays cell cycle progression, induces apoptosis, and decreases telomerase activity in human hepatocytes. Toxicol Sci. 2009 Sep;111(1):120-30. doi: 10.1093/toxsci/kfp136. Epub 2009 Jun 18.
• [75] Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
• [76] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [77] Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner. Carcinogenesis. 2009 Aug;30(8):1320-9. doi: 10.1093/carcin/bgp138. Epub 2009 Jun 5.
• [78] Characteristics of P388/VMDRC.04, a simple, sensitive model for studying P-glycoprotein antagonists. Cancer Res. 1994 Feb 1;54(3):730-7.
• [79] Michaelis-Menten kinetic analysis of drugs of abuse to estimate their affinity to human P-glycoprotein. Toxicol Lett. 2013 Feb 27;217(2):137-42. doi: 10.1016/j.toxlet.2012.12.012. Epub 2012 Dec 27.
• [80] Editor's Highlight: PlacentalDisposition and Effects of Crizotinib: An Ex Vivo Study in the Isolated Dual-Side Perfused Human Cotyledon. Toxicol Sci. 2017 Jun 1;157(2):500-509. doi: 10.1093/toxsci/kfx063.
• [81] Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs. Pharmacogenet Genomics. 2008 May;18(5):390-402. doi: 10.1097/FPC.0b013e3282f85e36.
• [82] Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells. Cancer Sci. 2005 Jun;96(6):372-6. doi: 10.1111/j.1349-7006.2005.00057.x.
• [83] Clinical pharmacokinetic monitoring of itraconazole is warranted in only a subset of patients. Ther Drug Monit. 2005 Jun;27(3):322-33. doi: 10.1097/01.ftd.0000150135.22645.ea.
• [84] Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein. Psychopharmacology (Berl). 2006 Sep;187(4):415-23. doi: 10.1007/s00213-006-0437-9. Epub 2006 Jun 30.
• [85] Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro. Haematologica. 2002 Feb;87(2):167-76.
• [86] Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells. Cancer Res. 1988 Sep 1;48(17):4926-32.
• [87] Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78.
• [88] Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation. Pharmacogenetics. 1997 Jun;7(3):211-21.
• [89] Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes. Arch Biochem Biophys. 2003 Jan 1;409(1):32-44.
• [90] Differential inhibition of human CYP2C8 and molecular docking interactions elicited by sorafenib and its major N-oxide metabolite. Chem Biol Interact. 2021 Apr 1;338:109401. doi: 10.1016/j.cbi.2021.109401. Epub 2021 Feb 5.
• [91] Dabrafenib inhibits ABCG2 and cytochrome P450 isoenzymes; potential implications for combination anticancer therapy. Toxicol Appl Pharmacol. 2022 Jan 1;434:115797. doi: 10.1016/j.taap.2021.115797. Epub 2021 Nov 13.
• [92] Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class. Toxicol Lett. 2016 Jan 22;241:82-94.
• [93] Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes. Chem Biol Interact. 2016 Aug 5;255:31-44.
• [94] Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR. Yakugaku Zasshi. 2002 May;122(5):339-61.
• [95] Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor. Chem Res Toxicol. 2014 Feb 17;27(2):304-308.
• [96] Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin. J Biol Chem. 2004 Jul 9;279(28):29295-301. doi: 10.1074/jbc.M400580200. Epub 2004 Apr 28.
• [97] Identification of novel agonists by high-throughput screening and molecular modelling of human constitutive androstane receptor isoform 3. Arch Toxicol. 2019 Aug;93(8):2247-2264. doi: 10.1007/s00204-019-02495-6. Epub 2019 Jul 16.
• [98] Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor. Mol Pharmacol. 2005 Jun;67(6):1954-65.
• [99] Characterization of human cytochrome P450 induction by pesticides. Toxicology. 2012 Mar 29;294(1):17-26.
• [100] Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. Arch Biochem Biophys. 2005 Feb 1;434(1):75-85.
• [101] Pyrethroids: cytotoxicity and induction of CYP isoforms in human hepatocytes. Drug Metabol Drug Interact. 2008;23(3-4):211-36.
• [102] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [103] THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
• [104] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [105] Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
• [106] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [107] Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
• [108] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
• [109] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [110] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [111] Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity. Anat Cell Biol. 2016 Sep;49(3):165-176. doi: 10.5115/acb.2016.49.3.165. Epub 2016 Sep 29.
• [112] Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
• [113] Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
• [114] Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
• [115] Inactivation of cytochrome c oxidase by mutant SOD1s in mouse motoneuronal NSC-34 cells is independent from copper availability but is because of nitric oxide. J Neurochem. 2010 Jan;112(1):183-92. doi: 10.1111/j.1471-4159.2009.06441.x. Epub 2009 Oct 20.
• [116] Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen. Brain. 2006 Jul;129(Pt 7):1693-709. doi: 10.1093/brain/awl118. Epub 2006 May 15.
• [117] Development of an alternative zebrafish model for drug-induced intestinal toxicity. J Appl Toxicol. 2018 Feb;38(2):259-273. doi: 10.1002/jat.3520. Epub 2017 Oct 13.
• [118] Epinephrine upregulates superoxide dismutase in human coronary artery endothelial cells. Free Radic Biol Med. 2001 Jan 15;30(2):148-53.
• [119] Molecular pathways in the chemosensitization of cisplatin by quercetin in human head and neck cancer. Cancer Biol Ther. 2005 Sep;4(9):949-55.
• [120] Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
• [121] Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
• [122] Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
• [123] P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
• [124] Cissus quadrangularis ethanol extract upregulates superoxide dismutase, glutathione peroxidase and endothelial nitric oxide synthase expression in hydrogen peroxide-injured human ECV304 cells. J Ethnopharmacol. 2012 Sep 28;143(2):664-72.
• [125] Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
• [126] Manganese superoxide dismutase is a promising target for enhancing chemosensitivity of basal-like breast carcinoma. Antioxid Redox Signal. 2014 May 20;20(15):2326-46. doi: 10.1089/ars.2013.5295. Epub 2013 Nov 14.
• [127] Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
• [128] Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
• [129] Factors associated with the therapeutic efficacy of retinoic acids on malignant lymphomas. J Formos Med Assoc. 1997 Jul;96(7):525-34.
• [130] Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
• [131] Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program. Chem Res Toxicol. 2010 Mar 15;23(3):578-90. doi: 10.1021/tx900325g.
• [132] Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.
• [133] Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
• [134] Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment. Pharmaceutics. 2021 Sep 7;13(9):1415. doi: 10.3390/pharmaceutics13091415.
• [135] Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways. World J Gastrointest Oncol. 2022 Feb 15;14(2):450-477. doi: 10.4251/wjgo.v14.i2.450.
• [136] Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
• [137] Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
• [138] Pentosan polysulfate decreases proliferation and extracellular matrix deposition by vascular smooth muscle cells isolated from failed hemodialysis access grafts. Clin Nephrol. 2000 Aug;54(2):121-7.
• [139] Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
• [140] Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
• [141] Matrix metalloproteinase-9 is involved in chronic lymphocytic leukemia cell response to fludarabine and arsenic trioxide. PLoS One. 2014 Jun 23;9(6):e99993. doi: 10.1371/journal.pone.0099993. eCollection 2014.
• [142] Simvastatin, an HMG-CoA reductase inhibitor, reduced the expression of matrix metalloproteinase-9 (Gelatinase B) in osteoblastic cells and HT1080 fibrosarcoma cells. J Pharmacol Sci. 2004 Apr;94(4):403-9. doi: 10.1254/jphs.94.403.
• [143] Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
• [144] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
• [145] Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20;2:55. doi: 10.1186/1755-8794-2-55.
• [146] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
• [147] Folic acid enforces DNA methylation-mediated transcriptional silencing of PTEN, APC and RARbeta2 tumour suppressor genes in breast cancer. Biochem Biophys Res Commun. 2013 Jan 11;430(2):623-8. doi: 10.1016/j.bbrc.2012.11.103. Epub 2012 Dec 3.
• [148] Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
• [149] Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
• [150] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [151] Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
• [152] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [153] Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
• [154] Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
• [155] Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
• [156] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
• [157] Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
• [158] Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
• [159] The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
• [160] Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
• [161] Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci. 2014 Jun;139(2):328-37. doi: 10.1093/toxsci/kfu053. Epub 2014 Mar 27.
• [162] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [163] Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
• [164] Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
• [165] Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
• [166] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
• [167] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [168] Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
• [169] 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
• [170] -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
• [171] Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Res Treat. 2010 Feb;119(3):575-91. doi: 10.1007/s10549-009-0355-8. Epub 2009 Mar 15.
• [172] The protective effect of quercetin against oxidative stress in the human RPE in vitro. Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1712-20. doi: 10.1167/iovs.07-0477.
• [173] Nitric oxide regulates lung carcinoma cell anoikis through inhibition of ubiquitin-proteasomal degradation of caveolin-1. J Biol Chem. 2009 Oct 9;284(41):28476-28484. doi: 10.1074/jbc.M109.050864. Epub 2009 Aug 25.
• [174] Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
• [175] Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
• [176] Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
• [177] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [178] Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
• [179] Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
• [180] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [181] Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
• [182] Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
• [183] The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
• [184] Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
• [185] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
• [186] Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
• [187] Molecular characterization of a toxicological tipping point during human stem cell differentiation. Reprod Toxicol. 2020 Jan;91:1-13. doi: 10.1016/j.reprotox.2019.10.001. Epub 2019 Oct 7.
• [188] A high-throughput screen for teratogens using human pluripotent stem cells. Toxicol Sci. 2014 Jan;137(1):76-90. doi: 10.1093/toxsci/kft239. Epub 2013 Oct 23.
• [189] Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2011 Feb;123(3-5):140-50.
• [190] Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
• [191] Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
• [192] Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
• [193] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [194] The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. Biochemistry. 2009 Nov 3;48(43):10267-74. doi: 10.1021/bi9009677.
• [195] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [196] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [197] Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
• [198] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [199] Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
• [200] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [201] Gene expression profile analysis of gallic acid-induced cell death process. Sci Rep. 2021 Aug 18;11(1):16743. doi: 10.1038/s41598-021-96174-1.
• [202] PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62.
• [203] Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan;92(1):469-485.
• [204] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [205] Amifostine impairs p53-mediated apoptosis of human myeloid leukemia cells. Mol Cancer Ther. 2003 Sep;2(9):893-900.
• [206] Effect of ellagic acid on the expression of human telomerase reverse transcriptase (hTERT) alpha+beta+ transcript in estrogen receptor-positive MCF-7 breast cancer cells. Clin Biochem. 2009 Sep;42(13-14):1358-62. doi: 10.1016/j.clinbiochem.2009.05.017. Epub 2009 Jun 6.
• [207] Antiproliferative effects of gefitinib are associated with suppression of E2F-1 expression and telomerase activity. Anticancer Res. 2006 Sep-Oct;26(5A):3387-91.
• [208] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [209] Inhibitory effects of selenium on telomerase activity and hTERT expression in cadmium-transformed 16HBE cells. Biomed Environ Sci. 2007 Aug;20(4):307-12.
• [210] Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast cancer cells. BMC Cancer. 2010 Jul 22;10:390. doi: 10.1186/1471-2407-10-390.
• [211] Analysis of telomerase activity and RNA expression in a patient with acute promyelocytic leukemia treated with all-trans retinoic acid. Pediatr Blood Cancer. 2006 Apr;46(4):506-11. doi: 10.1002/pbc.20392.
• [212] Characterization of the functional and growth properties of long-term cell cultures established from a human somatostatinoma. Endocr Relat Cancer. 2006 Mar;13(1):79-93. doi: 10.1677/erc.1.00988.
• [213] Characterization of arsenic-induced cytogenetic alterations in acute promyelocytic leukemia cell line, NB4. Med Oncol. 2012 Jun;29(2):1209-16. doi: 10.1007/s12032-011-9946-4. Epub 2011 May 5.
• [214] Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. Mol Cancer. 2006 May 18;5:20. doi: 10.1186/1476-4598-5-20.
• [215] Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
• [216] mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
• [217] Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
• [218] Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
• [219] Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
• [220] Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
• [221] Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
• [222] Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin. Invest New Drugs. 2011 Oct;29(5):945-52. doi: 10.1007/s10637-010-9450-2. Epub 2010 May 13.
• [223] Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene. 2005 Sep 15;24(41):6213-21. doi: 10.1038/sj.onc.1208774.
• [224] Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest. 2009 Jul;27(6):604-12. doi: 10.1080/07357900802337191.
• [225] Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. Apoptosis. 2006 Sep;11(9):1503-12. doi: 10.1007/s10495-006-8896-3.
• [226] Influence of resveratrol on rheumatoid fibroblast-like synoviocytes analysed with gene chip transcription. Phytomedicine. 2013 Feb 15;20(3-4):310-8. doi: 10.1016/j.phymed.2012.09.020. Epub 2012 Nov 6.
• [227] Research resource: STR DNA profile and gene expression comparisons of human BG-1 cells and a BG-1/MCF-7 clonal variant. Mol Endocrinol. 2014 Dec;28(12):2072-81.
• [228] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
• [229] Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
• [230] Alcohol triggered bile acid disequilibrium by suppressing BSEP to sustain hepatocellular carcinoma progression. Chem Biol Interact. 2022 Apr 1;356:109847. doi: 10.1016/j.cbi.2022.109847. Epub 2022 Feb 9.
• [231] Bortezomib induces caspase-dependent apoptosis in Hodgkin lymphoma cell lines and is associated with reduced c-FLIP expression: a gene expression profiling study with implications for potential combination therapies. Leuk Res. 2008 Feb;32(2):275-85. doi: 10.1016/j.leukres.2007.05.024. Epub 2007 Jul 19.
• [232] A genomic approach to predict synergistic combinations for breast cancer treatment. Pharmacogenomics J. 2013 Feb;13(1):94-104. doi: 10.1038/tpj.2011.48. Epub 2011 Nov 15.
• [233] Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
• [234] Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
• [235] Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol Rep. 2006 Jun;15(6):1453-60.
• [236] Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
• [237] SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-B/STAT3 complex to its promoter in malignant lymphoid cells. Cell Death Dis. 2013 May 16;4(5):e635. doi: 10.1038/cddis.2013.159.
• [238] Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
• [239] Febuxostat Increases Ventricular Arrhythmogenesis Through Calcium Handling Dysregulation in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Toxicol Sci. 2022 Sep 24;189(2):216-224. doi: 10.1093/toxsci/kfac073.
• [240] EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS One. 2011;6(6):e18691. doi: 10.1371/journal.pone.0018691. Epub 2011 Jun 2.
• [241] Time course study of A formation and neurite outgrowth disruption in differentiated human neuroblastoma cells exposed to H2O2: protective role of autophagy. Toxicol In Vitro. 2013 Sep;27(6):1780-8. doi: 10.1016/j.tiv.2013.05.005. Epub 2013 May 29.
• [242] Multitarget effects of quercetin in leukemia. Cancer Prev Res (Phila). 2014 Dec;7(12):1240-50. doi: 10.1158/1940-6207.CAPR-13-0383. Epub 2014 Oct 7.
• [243] Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
• [244] Arsenic trioxide induces autophagic cell death in osteosarcoma cells via the ROS-TFEB signaling pathway. Biochem Biophys Res Commun. 2018 Jan 29;496(1):167-175. doi: 10.1016/j.bbrc.2018.01.018. Epub 2018 Jan 4.
• [245] Effects of SIDT2 on the miR-25/NOX4/HuR axis and SIRT3 mRNA stability lead to ROS-mediated TNF- expression in hydroquinone-treated leukemia cells. Cell Biol Toxicol. 2023 Oct;39(5):2207-2225. doi: 10.1007/s10565-022-09705-5. Epub 2022 Mar 18.
• [246] AMPK activation induced by promethazine increases NOXA expression and Beclin-1 phosphorylation and drives autophagy-associated apoptosis in chronic myeloid leukemia. Chem Biol Interact. 2020 Jan 5;315:108888. doi: 10.1016/j.cbi.2019.108888. Epub 2019 Nov 2.
• [247] Endoplasmic reticulum stress contributes to autophagy and apoptosis in cantharidin-induced nephrotoxicity. Food Chem Toxicol. 2022 May;163:112986. doi: 10.1016/j.fct.2022.112986. Epub 2022 Apr 6.
• [248] Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-kappaB activity. Toxicol Sci. 2002 Apr;66(2):233-43. doi: 10.1093/toxsci/66.2.233.
• [249] Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
• [250] Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
• [251] ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2007 May;6(5):1579-87. doi: 10.1158/1535-7163.MCT-06-0814.
• [252] Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
• [253] Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
• [254] Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
• [255] Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. Cancer Res. 2002 Nov 1;62(21):6006-10.
• [256] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [257] A protein-coated magnetic beads as a tool for the rapid drug-protein binding study. J Pharm Biomed Anal. 2010 Jul 8;52(3):420-4. doi: 10.1016/j.jpba.2009.06.023. Epub 2009 Jun 18.
• [258] The three recombinant domains of human serum albumin. Structural characterization and ligand binding properties. J Biol Chem. 1999 Oct 8;274(41):29303-10. doi: 10.1074/jbc.274.41.29303.
• [259] Exploring binding properties of sertraline with human serum albumin: Combination of spectroscopic and molecular modeling studies. Chem Biol Interact. 2015 Dec 5;242:235-46. doi: 10.1016/j.cbi.2015.10.006. Epub 2015 Oct 22.
• [260] Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
• [261] Use of peak decay analysis and affinity microcolumns containing silica monoliths for rapid determination of drug-protein dissociation rates. J Chromatogr A. 2011 Apr 15;1218(15):2072-8. doi: 10.1016/j.chroma.2010.09.070. Epub 2010 Oct 16.
• [262] [Colchicine in chronic liver disease of alcoholic etiology. Double-blind, randomized study of its effects on blood levels of plasma proteins and clinical course in patients]. Rev Assoc Med Bras (1992). 1995 May-Jun;41(3):207-12.
• [263] Editor's Highlight: Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues. Toxicol Sci. 2016 Dec;154(2):354-367. doi: 10.1093/toxsci/kfw169. Epub 2016 Sep 7.
• [264] Covalent binding of the flavonoid quercetin to human serum albumin. J Agric Food Chem. 2005 May 18;53(10):4194-7. doi: 10.1021/jf050061m.
• [265] Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
• [266] Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution. J Biol Chem. 2014 Aug 1;289(31):21386-400. doi: 10.1074/jbc.M113.528463. Epub 2014 Jun 18.
• [267] Troglitazone suppresses cell growth of KU812 cells independently of PPARgamma. Eur J Pharmacol. 2002 Feb 1;436(1-2):7-13. doi: 10.1016/s0014-2999(01)01577-1.
• [268] D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
• [269] Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
• [270] Pyrazinamide-induced hepatotoxicity is alleviated by 4-PBA via inhibition of the PERK-eIF2-ATF4-CHOP pathway. Toxicology. 2017 Mar 1;378:65-75. doi: 10.1016/j.tox.2017.01.002. Epub 2017 Jan 4.
• [271] Lon protease and eiF2 are involved in acute, but not prolonged, antiretroviral induced stress response in HepG2 cells. Chem Biol Interact. 2016 May 25;252:82-6. doi: 10.1016/j.cbi.2016.03.021. Epub 2016 Apr 1.
• [272] Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling. J Lipid Res. 2009 Sep;50(9):1814-23. doi: 10.1194/jlr.M800343-JLR200. Epub 2009 Apr 21.
• [273] High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells. Blood. 1993 Nov 15;82(10):3133-40.
• [274] Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples. Data Brief. 2016 Mar 26;7:1052-1057. doi: 10.1016/j.dib.2016.03.069. eCollection 2016 Jun.
• [275] Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
• [276] Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
• [277] Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
• [278] Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem. 2002 Nov 15;277(46):43648-58. doi: 10.1074/jbc.M203214200. Epub 2002 Sep 6.
• [279] [Regulation mechanism of autophagy-related protein LC3 by c-Jun in methotrexate resistant human choriocarcinoma JEG-3 cells]. Zhonghua Fu Chan Ke Za Zhi. 2014 Jul;49(7):531-5.
• [280] Indomethacin inhibits cell growth of medullary thyroid carcinoma by reducing cell cycle progression into S phase. Exp Biol Med (Maywood). 2008 Nov;233(11):1433-40. doi: 10.3181/0804-RM-127. Epub 2008 Sep 12.
• [281] Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer. Endocr Relat Cancer. 2011 Apr 28;18(3):333-45. doi: 10.1530/ERC-10-0262. Print 2011 Jun.
• [282] Effects and mechanisms of betulinic acid on improving EGFR TKI-resistance of lung cancer cells. Environ Toxicol. 2018 Nov;33(11):1153-1159.
• [283] BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
• [284] Sulindac induces specific degradation of the HPV oncoprotein E7 and causes growth arrest and apoptosis in cervical carcinoma cells. Cancer Lett. 2007 Jan 8;245(1-2):103-11. doi: 10.1016/j.canlet.2005.12.034. Epub 2006 Feb 20.
• [285] Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance. Exp Cell Res. 2012 Jun 10;318(10):1146-59.
• [286] HMG-CoA reductase inhibitor simvastatin inhibits cell cycle progression at the G1/S checkpoint in immortalized lymphocytes from Alzheimer's disease patients independently of cholesterol-lowering effects. J Pharmacol Exp Ther. 2008 Jan;324(1):352-9. doi: 10.1124/jpet.107.128959. Epub 2007 Oct 10.
• [287] Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
• [288] Melatonin attenuates cisplatin-induced HepG2 cell death via the regulation of mTOR and ERCC1 expressions. World J Hepatol. 2014 Apr 27;6(4):230-42. doi: 10.4254/wjh.v6.i4.230.
• [289] Pemetrexed downregulates ERCC1 expression and enhances cytotoxicity effected by resveratrol in human nonsmall cell lung cancer cells. Naunyn Schmiedebergs Arch Pharmacol. 2013 Dec;386(12):1047-59. doi: 10.1007/s00210-013-0905-9. Epub 2013 Aug 3.
• [290] A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
• [291] Combination of oxaliplatin and irinotecan on human colon cancer cell lines: activity in vitro and in vivo. Anticancer Drugs. 2001 Oct;12(9):741-51. doi: 10.1097/00001813-200110000-00006.
• [292] Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
• [293] Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
• [294] Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
• [295] Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
• [296] Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
• [297] Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth. Exp Cell Res. 2010 Aug 1;316(13):2174-88. doi: 10.1016/j.yexcr.2010.04.027. Epub 2010 May 8.
• [298] Quercetin augments TRAIL-induced apoptotic death: involvement of the ERK signal transduction pathway. Biochem Pharmacol. 2008 May 15;75(10):1946-58. doi: 10.1016/j.bcp.2008.02.016. Epub 2008 Mar 10.
• [299] Peroxisome proliferator-activated receptor-gamma ligands suppress fibronectin gene expression in human lung carcinoma cells: involvement of both CRE and Sp1. Am J Physiol Lung Cell Mol Physiol. 2005 Sep;289(3):L419-28. doi: 10.1152/ajplung.00002.2005. Epub 2005 May 20.
• [300] Mechanistic basis for overcoming platinum resistance using copper chelating agents. Mol Cancer Ther. 2012 Nov;11(11):2483-94. doi: 10.1158/1535-7163.MCT-12-0580. Epub 2012 Aug 21.
• [301] Regulation of the high-affinity copper transporter (hCtr1) expression by cisplatin and heavy metals. J Biol Inorg Chem. 2014 Jan;19(1):17-27. doi: 10.1007/s00775-013-1051-z. Epub 2013 Oct 17.
• [302] Thalidomide and a thalidomide analogue inhibit endothelial cell proliferation in vitro. J Neurooncol. 1999 Jun;43(2):109-14. doi: 10.1023/a:1006202700039.
• [303] The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription. Chem Biol Interact. 2014 Aug 5;219:123-32. doi: 10.1016/j.cbi.2014.05.019. Epub 2014 Jun 4.
• [304] Dimethyl Fumarate Therapy Significantly Improves the Responsiveness of T Cells in Multiple Sclerosis Patients for Immunoregulation by Regulatory T Cells. Int J Mol Sci. 2017 Jan 28;18(2):271. doi: 10.3390/ijms18020271.
• [305] In vitro antitumoral effects of the steroid ouabain on human thyroid papillary carcinoma cell lines. Environ Toxicol. 2021 Jul;36(7):1338-1348. doi: 10.1002/tox.23130. Epub 2021 Mar 24.
• [306] From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
• [307] Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents. Leuk Res. 2010 Jul;34(7):917-24. doi: 10.1016/j.leukres.2009.12.002. Epub 2010 Feb 8.
• [308] Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells. Biochem J. 1991 Aug 1;277 ( Pt 3)(Pt 3):659-64. doi: 10.1042/bj2770659.
• [309] Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
• [310] Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
• [311] Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
• [312] Proteomics investigation of protein expression changes in ouabain induced apoptosis in human umbilical vein endothelial cells. J Cell Biochem. 2008 Jun 1;104(3):1054-64. doi: 10.1002/jcb.21691.
• [313] Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease. Proteomics. 2008 Apr;8(8):1595-607. doi: 10.1002/pmic.200700556.
• [314] Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
• [315] Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis. Int J Cancer. 2004 Mar 20;109(2):220-9. doi: 10.1002/ijc.11692.
• [316] NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
• [317] Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013 Apr 25;203(2):412-22. doi: 10.1016/j.cbi.2013.03.011. Epub 2013 Mar 22.
• [318] Cigarette smoke and asbestos activate poly-ADP-ribose polymerase in alveolar epithelial cells. J Investig Med. 2001 Jan;49(1):68-76. doi: 10.2310/6650.2001.34092.
• [319] The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. doi: 10.1002/(sici)1099-0461(1999)13:6<338::aid-jbt8>3.0.co;2-7.
• [320] Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
• [321] Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
• [322] Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells. Clin Exp Immunol. 2007 May;148(2):288-95. doi: 10.1111/j.1365-2249.2007.03335.x. Epub 2007 Feb 7.
• [323] Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
• [324] Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol. 2012 May;57(5):483-90. doi: 10.1016/j.archoralbio.2011.10.007. Epub 2011 Nov 25.
• [325] Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
• [326] Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
• [327] ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
• [328] An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
• [329] Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med. 2000 Jan;161(1):249-56. doi: 10.1164/ajrccm.161.1.9804096.
• [330] 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
• [331] Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
• [332] Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
• [333] Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
• [334] Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
• [335] Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
• [336] Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
• [337] Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. Int J Mol Sci. 2016 Dec 23;18(1):26. doi: 10.3390/ijms18010026.
• [338] The estrogen receptor influences microtubule-associated protein tau (MAPT) expression and the selective estrogen receptor inhibitor fulvestrant downregulates MAPT and increases the sensitivity to taxane in breast cancer cells. Breast Cancer Res. 2010;12(3):R43. doi: 10.1186/bcr2598. Epub 2010 Jun 28.
• [339] Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression. Mol Neurodegener. 2006 Jul 26;1:6. doi: 10.1186/1750-1326-1-6.
• [340] Differential effects of simvastatin and pravastatin on expression of Alzheimer's disease-related genes in human astrocytes and neuronal cells. J Lipid Res. 2009 Oct;50(10):2095-102. doi: 10.1194/jlr.M900236-JLR200. Epub 2009 May 21.
• [341] Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
• [342] Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
• [343] Identification of human cell responses to benzene and benzene metabolites. Genomics. 2007 Sep;90(3):324-33.
• [344] Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
• [345] Crosstalk between alveolar macrophages and alveolar epithelial cells/fibroblasts contributes to the pulmonary toxicity of gefitinib. Toxicol Lett. 2021 Mar 1;338:1-9. doi: 10.1016/j.toxlet.2020.11.011. Epub 2020 Nov 25.
• [346] Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
• [347] Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
• [348] Dimethyl Fumarate Inhibits the Nuclear Factor B Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. J Biol Chem. 2016 Feb 12;291(7):3639-47. doi: 10.1074/jbc.M115.679704. Epub 2015 Dec 18.
• [349] Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients. Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1194-9. doi: 10.1161/01.atv.0000022694.16328.cc.
• [350] Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFB and AhR and EGFR-ERK pathway. Toxicol Appl Pharmacol. 2011 Sep 1;255(2):138-49.
• [351] A copper-hydrogen peroxide redox system induces dityrosine cross-links and chemokine oligomerisation. Cytokine. 2011 Dec;56(3):669-75. doi: 10.1016/j.cyto.2011.08.025. Epub 2011 Oct 1.
• [352] Regulatory role of nitric oxide on monocyte-derived dendritic cell functions. J Interferon Cytokine Res. 2003 Aug;23(8):423-31. doi: 10.1089/107999003322277838.
• [353] Simvastatin down regulates mRNA expression of RANTES and CCR5 in posttransplant renal recipients with hyperlipidemia. Transplant Proc. 2006 Nov;38(9):2899-904. doi: 10.1016/j.transproceed.2006.08.136.
• [354] 13-cis retinoic acid inhibits development and progression of chronic allograft nephropathy. Am J Pathol. 2005 Jul;167(1):285-98. doi: 10.1016/S0002-9440(10)62973-2.
• [355] 2,3,7,8-tetrachlorodibenzo-p-dioxin augments the modulation of gene expression mediated by the thyroid hormone receptor. Toxicol Appl Pharmacol. 2004 Feb 1;194(3):201-10. doi: 10.1016/j.taap.2003.09.010.
• [356] Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
• [357] G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J Biol Chem. 1993 Apr 15;268(11):8298-308.
• [358] Synthesis and antitumor evaluation of nitrovinyl biphenyls: anticancer agents based on allocolchicines. ChemMedChem. 2011 May 2;6(5):859-68. doi: 10.1002/cmdc.201100019. Epub 2011 Apr 6.
• [359] Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
• [360] Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. J Toxicol Sci. 2015 Jun;40(3):329-38. doi: 10.2131/jts.40.329.
• [361] Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Implication for its cardiac developmental toxicity. Toxicology. 2020 Apr 15;435:152422. doi: 10.1016/j.tox.2020.152422. Epub 2020 Feb 26.
• [362] Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. Bioorg Med Chem. 2007 Jul 15;15(14):4863-75. doi: 10.1016/j.bmc.2007.04.057. Epub 2007 May 3.
• [363] Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochem Pharmacol. 2011 Feb 15;81(4):510-7. doi: 10.1016/j.bcp.2010.11.014. Epub 2010 Nov 27.
• [364] Actinomycin D inhibits the expression of the cystine/glutamate transporter xCT via attenuation of CD133 synthesis in CD133(+) HCC. Chem Biol Interact. 2019 Aug 25;309:108713. doi: 10.1016/j.cbi.2019.06.026. Epub 2019 Jun 19.
• [365] Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells. Ann Hematol. 2010 Nov;89(11):1115-24. doi: 10.1007/s00277-010-0988-z. Epub 2010 May 25.
• [366] The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
• [367] The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. DNA Repair (Amst). 2004 Mar 4;3(3):235-44. doi: 10.1016/j.dnarep.2003.10.014.
• [368] Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006 Jan 10;24(2):274-87. doi: 10.1200/JCO.2005.02.9405. Epub 2005 Dec 19.
• [369] Ouabain induces apoptotic cell death in human prostate DU 145 cancer cells through DNA damage and TRAIL pathways. Environ Toxicol. 2019 Dec;34(12):1329-1339. doi: 10.1002/tox.22834. Epub 2019 Aug 21.
• [370] Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage. Carcinogenesis. 2014 Mar;35(3):692-702. doi: 10.1093/carcin/bgt366. Epub 2013 Nov 5.
• [371] Induction of the DNA repair gene O6-methylguanine-DNA methyltransferase by dexamethasone in glioblastomas. J Neurosurg. 2004 Oct;101(4):659-63. doi: 10.3171/jns.2004.101.4.0659.
• [372] Phenytoin may increase the efficacy of temozolomide by methylating DNA-repair enzyme, O6-methylguanine-DNA methyltransferase in patients with glioblastoma. Med Hypotheses. 2005;65(4):819-20. doi: 10.1016/j.mehy.2005.04.007.
• [373] Pharmacokinetic, biochemical and clinical effects of dimethyltriazenoimidazole-4-carboxamide-bischloroethylnitrosourea combination therapy in patients with advanced breast cancer. Int J Cancer. 2003 Feb 20;103(5):686-92. doi: 10.1002/ijc.10849.
• [374] Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N'-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells. Mol Pharmacol. 2008 Aug;74(2):517-26. doi: 10.1124/mol.107.043620. Epub 2008 May 20.
• [375] Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
• [376] The myeloma cell antigen syndecan-1 is lost by apoptotic myeloma cells. Br J Haematol. 1998 Mar;100(4):637-46. doi: 10.1046/j.1365-2141.1998.00623.x.
• [377] Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 2011 Mar;13(3):267-79. doi: 10.1093/neuonc/noq195. Epub 2011 Feb 3.
• [378] NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. J Biol Chem. 2021 Jan-Jun;296:100624. doi: 10.1016/j.jbc.2021.100624. Epub 2021 Apr 2.
• [379] Rifampicin-induced injury in L02 cells is alleviated by 4-PBA via inhibition of the PERK-ATF4-CHOP pathway. Toxicol In Vitro. 2016 Oct;36:186-196. doi: 10.1016/j.tiv.2016.07.017. Epub 2016 Jul 26.
• [380] Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia. J Cell Mol Med. 2018 Mar;22(3):1614-1626.
• [381] Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
• [382] Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
• [383] Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation. Toxicol Appl Pharmacol. 2021 Mar 15;415:115450. doi: 10.1016/j.taap.2021.115450. Epub 2021 Feb 9.
• [384] CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models. Genes Cancer. 2014 Jul;5(7-8):261-72. doi: 10.18632/genesandcancer.24.
• [385] The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
• [386] Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
• [387] Chromium III histidinate exposure modulates gene expression in HaCaT human keratinocytes exposed to oxidative stress. Biol Trace Elem Res. 2010 Oct;137(1):23-39.
• [388] A dual role of p21waf1/cip1 gene in apoptosis of HEp-2 treated with cisplatin or methotrexate. Cancer Gene Ther. 2008 Sep;15(9):576-90. doi: 10.1038/cgt.2008.28. Epub 2008 May 16.
• [389] Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
• [390] Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Int J Mol Sci. 2023 Mar 15;24(6):5604. doi: 10.3390/ijms24065604.
• [391] The Effect of GADD45a on Furazolidone-Induced S-Phase Cell-Cycle Arrest in Human Hepatoma G2 Cells. J Biochem Mol Toxicol. 2015 Oct;29(10):489-495. doi: 10.1002/jbt.21719. Epub 2015 Jun 11.
• [392] Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells. Oncogene. 2004 Jun 3;23(26):4614-23. doi: 10.1038/sj.onc.1207598.
• [393] Estrogen receptor regulates E2F1 expression to mediate tamoxifen resistance. Mol Cancer Res. 2010 Mar;8(3):343-52. doi: 10.1158/1541-7786.MCR-09-0395. Epub 2010 Mar 9.
• [394] Fluoxetine mediates G0/G1 arrest by inducing functional inhibition of cyclin dependent kinase subunit (CKS)1. Biochem Pharmacol. 2008 May 15;75(10):1924-34. doi: 10.1016/j.bcp.2008.02.013. Epub 2008 Feb 17.
• [395] Retinoic acid regulates cell cycle progression and cell differentiation in human monocytic THP-1 cells. Exp Cell Res. 2004 Jul 1;297(1):68-81. doi: 10.1016/j.yexcr.2004.02.017.
• [396] [P27(Kip1), cyclin E and endogenous TGF-beta1 changes in apoptosis of NB4 cells induced by As(2)O(3) and/or TGF-beta1 and their significance]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Feb;17(1):74-9.
• [397] Oxidative stress induces protein phosphatase 2A-dependent dephosphorylation of the pocket proteins pRb, p107, and p130. J Biol Chem. 2003 May 23;278(21):19509-17. doi: 10.1074/jbc.M300511200. Epub 2003 Mar 5.
• [398] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [399] Redistribution of cell cycle by arsenic trioxide is associated with demethylation and expression changes of cell cycle related genes in acute promyelocytic leukemia cell line (NB4). Ann Hematol. 2018 Jan;97(1):83-93. doi: 10.1007/s00277-017-3163-y. Epub 2017 Nov 20.
• [400] Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
• [401] Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. Mol Cancer. 2010 Aug 20;9:220.
• [402] Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
• [403] Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway. J Biochem Mol Toxicol. 2023 Jun;37(6):e23328. doi: 10.1002/jbt.23328. Epub 2023 Feb 19.
• [404] Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
• [405] Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2015 Mar;35(3):1063-76. doi: 10.1111/liv.12626. Epub 2014 Jul 30.
• [406] Induction of CCAAT/enhancer-binding protein-homologous protein by cigarette smoke through the superoxide anion-triggered PERK-eIF2 pathway. Toxicology. 2011 Sep 5;287(1-3):105-12. doi: 10.1016/j.tox.2011.06.005. Epub 2011 Jun 15.
• [407] Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
• [408] High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities. Arch Toxicol. 2017 Mar;91(3):1367-1383. doi: 10.1007/s00204-016-1781-0. Epub 2016 Jun 29.
• [409] Utilization of causal reasoning of hepatic gene expression in rats to identify molecular pathways of idiosyncratic drug-induced liver injury. Toxicol Sci. 2014 Jan;137(1):234-48. doi: 10.1093/toxsci/kft232. Epub 2013 Oct 17.
• [410] Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
• [411] Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
• [412] Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
• [413] Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
• [414] eIF4E is a critical regulator of human papillomavirus (HPV)-immortalized cervical epithelial (H8) cell growth induced by nicotine. Toxicology. 2019 May 1;419:1-10. doi: 10.1016/j.tox.2019.02.017. Epub 2019 Mar 2.
• [415] Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
• [416] Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein. Autophagy. 2021 Oct;17(10):2783-2799. doi: 10.1080/15548627.2020.1841953. Epub 2020 Nov 9.
• [417] Repression of Kisspeptin1 weakens hydrogen peroxide-caused injury in HTR8 cells via adjusting PI3K/AKT/mTOR pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22461. doi: 10.1002/jbt.22461. Epub 2020 Feb 11.
• [418] Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals. Toxicol Lett. 2022 Feb 1;355:1-18. doi: 10.1016/j.toxlet.2021.10.013. Epub 2021 Nov 5.
• [419] Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways. PLoS One. 2012;7(10):e47516. doi: 10.1371/journal.pone.0047516. Epub 2012 Oct 18.
• [420] A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
• [421] Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR. Environ Toxicol. 2023 Aug;38(8):1874-1890. doi: 10.1002/tox.23814. Epub 2023 May 6.
• [422] Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
• [423] [Mechanisms underlying the effect of arsenic trioxide on proliferation inhibition and apoptosis induction in myeloma cell line u266]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Oct;15(5):982-5.
• [424] Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
• [425] Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
• [426] Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
• [427] Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
• [428] Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
• [429] Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
• [430] mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
• [431] Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
• [432] Carbamylation and oxidation of proteins lead to apoptotic death of lymphocytes. Chem Biol Interact. 2017 May 25;270:24-32. doi: 10.1016/j.cbi.2017.04.007. Epub 2017 Apr 8.
• [433] Actinomycin D and staurosporine, potent apoptosis inducers in vitro, are potentially effective chemotherapeutic agents against glioblastoma multiforme. Cancer Chemother Pharmacol. 2000;45(2):149-56. doi: 10.1007/s002800050023.
• [434] Quercetin-induced apoptosis of HL-60 cells by reducing PI3K/Akt. Mol Biol Rep. 2012 Jul;39(7):7785-93. doi: 10.1007/s11033-012-1621-0. Epub 2012 May 4.
• [435] Clonidine Induces Apoptosis of Human Corneal Epithelial Cells through Death Receptors-Mediated, Mitochondria-Dependent Signaling Pathway. Toxicol Sci. 2017 Mar 1;156(1):252-260. doi: 10.1093/toxsci/kfw249.
• [436] Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis. Endocrinology. 2003 Sep;144(9):3852-9. doi: 10.1210/en.2003-0098.
• [437] Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway. Free Radic Biol Med. 2019 Feb 1;131:225-236. doi: 10.1016/j.freeradbiomed.2018.12.008. Epub 2018 Dec 11.
• [438] Disease-modifying effects of glucosamine HCl involving regulation of metalloproteinases and chemokines activated by interleukin-1beta in human primary synovial fibroblasts. J Cell Biochem. 2008 May 1;104(1):38-50. doi: 10.1002/jcb.21597.
• [439] Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine. Cancer Sci. 2003 Oct;94(10):886-93.
• [440] Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Arthritis Rheum. 2012 Jun;64(6):1780-9. doi: 10.1002/art.34342. Epub 2011 Dec 19.
• [441] Synergistic promotion of breast cancer cells death by targeting molecular chaperone GRP78 and heat shock protein 70. J Cell Mol Med. 2009 Nov-Dec;13(11-12):4540-50. doi: 10.1111/j.1582-4934.2008.00575.x.
• [442] Arsenic trioxide induces apoptosis in chronic myelogenous leukemia K562 cells: possible involvement of p38 MAP kinase. J Biochem Mol Biol. 2002 Jul 31;35(4):377-83. doi: 10.5483/bmbrep.2002.35.4.377.
• [443] Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress. Biochim Biophys Acta. 2014 Feb;1843(2):253-64. doi: 10.1016/j.bbamcr.2013.10.017. Epub 2013 Nov 1.
• [444] Sevoflurane-mediated activation of p38-mitogen-activated stresskinase is independent of apoptosis in Jurkat T-cells. Anesth Analg. 2008 Apr;106(4):1150-60, table of contents. doi: 10.1213/ane.0b013e3181683d37.
• [445] Bisbenzamidine derivative, pentamidine represses DNA damage response through inhibition of histone H2A acetylation. Mol Cancer. 2010 Feb 9;9:34. doi: 10.1186/1476-4598-9-34.
• [446] DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B. Mol Cell Biol. 2008 Jan;28(2):752-71. doi: 10.1128/MCB.01799-07. Epub 2007 Nov 8.
• [447] Deletion of NAD(P)H:quinone oxidoreductase 1 represses Mre11-Rad50-Nbs1 complex protein expression in cisplatin-induced nephrotoxicity. Toxicol Lett. 2016 Jan 22;243:22-30.
• [448] Synergistic antiproliferative effect of arsenic trioxide combined with bortezomib in HL60 cell line and primary blasts from patients affected by myeloproliferative disorders. Cancer Genet Cytogenet. 2010 Jun;199(2):110-20. doi: 10.1016/j.cancergencyto.2010.02.010.
• [449] A model to identify novel targets involved in oxidative stress-induced apoptosis in human lung epithelial cells by RNA interference. Toxicol In Vitro. 2010 Feb;24(1):310-8. doi: 10.1016/j.tiv.2009.08.008. Epub 2009 Aug 23.
• [450] Nitric oxide inhibits execution of apoptosis at two distinct ATP-dependent steps upstream and downstream of mitochondrial cytochrome c release. Biochem Biophys Res Commun. 1999 Apr 29;258(1):215-21. doi: 10.1006/bbrc.1999.0491.
• [451] Palmitate increases the susceptibility of cells to drug-induced toxicity: an in vitro method to identify drugs with potential contraindications in patients with metabolic disease. Toxicol Sci. 2012 Oct;129(2):346-62. doi: 10.1093/toxsci/kfs208. Epub 2012 Jun 14.
• [452] Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. 2005 Jul 7;5:74. doi: 10.1186/1471-2407-5-74.
• [453] Simvastatin induces apoptosis and alters cytoskeleton in endometrial stromal cells. J Clin Endocrinol Metab. 2010 Jul;95(7):3453-9. doi: 10.1210/jc.2010-0072. Epub 2010 Apr 28.
• [454] Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. J Biol Chem. 2002 Jul 26;277(30):27393-400. doi: 10.1074/jbc.M201963200. Epub 2002 May 14.
• [455] Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
• [456] The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. Exp Eye Res. 2010 Jul;91(1):15-25.
• [457] Inhibiting AKT signaling pathway with cilostazol and meloxicam synergism for suppressing K562 cells in vitro. J Biochem Mol Toxicol. 2022 Nov;36(11):e23185. doi: 10.1002/jbt.23185. Epub 2022 Aug 3.
• [458] Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells. Br J Cancer. 2002 Feb 1;86(3):443-8. doi: 10.1038/sj.bjc.6600079.
• [459] Colchicine-induced apoptosis in human normal liver L-02 cells by mitochondrial mediated pathways. Toxicol In Vitro. 2012 Aug;26(5):649-55. doi: 10.1016/j.tiv.2012.01.024. Epub 2012 Feb 8.
• [460] Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
• [461] Blood cell oxidative stress precedes hemolysis in whole blood-liver slice co-cultures of rat, dog, and human tissues. Toxicol Appl Pharmacol. 2010 May 1;244(3):354-65. doi: 10.1016/j.taap.2010.01.017. Epub 2010 Feb 6.
• [462] Proton pump inhibitors block iron absorption through direct regulation of hepcidin via the aryl hydrocarbon receptor-mediated pathway. Toxicol Lett. 2020 Jan;318:86-91. doi: 10.1016/j.toxlet.2019.10.016. Epub 2019 Oct 24.
• [463] A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression. Exp Hematol. 2015 May;43(5):404-413.e5. doi: 10.1016/j.exphem.2015.01.005. Epub 2015 Jan 26.
• [464] Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J Biol Chem. 2006 Aug 11;281(32):22974-82. doi: 10.1074/jbc.M602098200. Epub 2006 May 31.
• [465] Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
• [466] Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1. Mol Endocrinol. 2010 May;24(5):969-80. doi: 10.1210/me.2009-0148. Epub 2010 Mar 8.
• [467] K-RAS transformation in prostate epithelial cell overcomes H2O2-induced apoptosis via upregulation of gamma-glutamyltransferase-2. Toxicol In Vitro. 2012 Apr;26(3):429-34. doi: 10.1016/j.tiv.2012.01.013. Epub 2012 Jan 17.
• [468] Troglitazone induces cytotoxicity in part by promoting the degradation of peroxisome proliferator-activated receptor co-activator-1 protein. Br J Pharmacol. 2010 Oct;161(4):771-81. doi: 10.1111/j.1476-5381.2010.00900.x.
• [469] Under ambient UVA exposure, pefloxacin exhibits both immunomodulatory and genotoxic effects via multiple mechanisms. J Photochem Photobiol B. 2018 Jan;178:593-605. doi: 10.1016/j.jphotobiol.2017.12.014. Epub 2017 Dec 15.
• [470] Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene. 2005 Feb 10;24(7):1231-43. doi: 10.1038/sj.onc.1208290.
• [471] In vitro antioxidant and antigenotoxic potentials of 3,5-O-di-galloylquinic acid extracted from Myrtus communis leaves and modulation of cell gene expression by H2O2. J Appl Toxicol. 2012 May;32(5):333-41.
• [472] HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage. FASEB J. 2005 Mar;19(3):476-8. doi: 10.1096/fj.04-2745fje. Epub 2004 Dec 29.
• [473] Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
• [474] Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
• [475] SP1 and SP3 mediate progesterone-dependent induction of the 17beta hydroxysteroid dehydrogenase type 2 gene in human endometrium. Biol Reprod. 2006 Oct;75(4):605-14.
• [476] Role of phenytoin in wound healing: microarray analysis of early transcriptional responses in human dermal fibroblasts. Biochem Biophys Res Commun. 2004 Feb 13;314(3):661-6. doi: 10.1016/j.bbrc.2003.12.146.
• [477] Specificity protein 1 (sp1) oscillation is involved in copper homeostasis maintenance by regulating human high-affinity copper transporter 1 expression. Mol Pharmacol. 2012 Mar;81(3):455-64. doi: 10.1124/mol.111.076422. Epub 2011 Dec 15.
• [478] Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line, MCF-7, induced by the anti-cancer drug, daunorubicin. Biochim Biophys Acta. 2009 Nov-Dec;1789(11-12):681-90. doi: 10.1016/j.bbagrm.2009.08.006. Epub 2009 Aug 19.
• [479] Propolis alleviates 4-aminobiphenyl-induced oxidative DNA damage by inhibition of CYP2E1 expression in human liver cells. Environ Toxicol. 2021 Aug;36(8):1504-1513. doi: 10.1002/tox.23147. Epub 2021 Apr 13.
• [480] Unpredicted Downregulation of RAD51 Suggests Genome Instability Induced by Tetrachlorobenzoquinone. Chem Res Toxicol. 2016 Dec 19;29(12):2184-2193. doi: 10.1021/acs.chemrestox.6b00369. Epub 2016 Nov 21.
• [481] Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3. Arch Toxicol. 2022 Jan;96(1):177-193. doi: 10.1007/s00204-021-03174-1. Epub 2021 Oct 19.
• [482] Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.
• [483] Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars. J Trauma. 2004 Nov;57(5):1032-7. doi: 10.1097/01.ta.0000114087.46566.eb.
• [484] Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells. J Biol Chem. 2017 Feb 17;292(7):2815-2829. doi: 10.1074/jbc.M116.745398. Epub 2017 Jan 4.
• [485] Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
• [486] Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
• [487] Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma. Int J Cancer. 2015 May 1;136(9):2055-64.
• [488] Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
• [489] Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
• [490] Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
• [491] Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
• [492] Comparison of protective effect of ascorbic acid on redox and endocannabinoid systems interactions in in vitro cultured human skin fibroblasts exposed to UV radiation and hydrogen peroxide. Arch Dermatol Res. 2017 May;309(4):285-303. doi: 10.1007/s00403-017-1729-0. Epub 2017 Mar 11.
• [493] Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells. Biomolecules. 2019 Jul 25;9(8):302. doi: 10.3390/biom9080302.
• [494] Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons. Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15676-81. doi: 10.1073/pnas.0405155101. Epub 2004 Oct 21.
• [495] Pro-oxidant induced DNA damage in human lymphoblastoid cells: homeostatic mechanisms of genotoxic tolerance. Toxicol Sci. 2012 Aug;128(2):387-97. doi: 10.1093/toxsci/kfs152. Epub 2012 Apr 26.
• [496] Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
• [497] An in vitro study on anti-carcinogenic effect of remdesivir in human ovarian cancer cells via generation of reactive oxygen species. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089257. doi: 10.1177/09603271221089257.
• [498] Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
• [499] Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. Med Oncol. 2010 Sep;27(3):833-42. doi: 10.1007/s12032-009-9294-9. Epub 2009 Sep 10.
• [500] Autophagy Inhibition Overcomes the Antagonistic Effect Between Gefitinib and Cisplatin in Epidermal Growth Factor Receptor Mutant Non--Small-Cell Lung Cancer Cells. Clin Lung Cancer. 2015 Sep;16(5):e55-66. doi: 10.1016/j.cllc.2015.03.006. Epub 2015 Apr 2.
• [501] MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
• [502] Harnessing autophagy to overcome mitogen-activated protein kinase kinase inhibitor-induced resistance in metastatic melanoma. Br J Dermatol. 2019 Feb;180(2):346-356. doi: 10.1111/bjd.17333. Epub 2018 Nov 25.
• [503] Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
• [504] Calcipotriol induces autophagy in HeLa cells and keratinocytes. J Invest Dermatol. 2011 Apr;131(4):990-3. doi: 10.1038/jid.2010.423. Epub 2011 Jan 13.
• [505] The antidepressants maprotiline and fluoxetine induce Type II autophagic cell death in drug-resistant Burkitt's lymphoma. Int J Cancer. 2011 Apr 1;128(7):1712-23. doi: 10.1002/ijc.25477. Epub 2010 May 25.
• [506] Autophagy contributes to 4-Amino-2-Trifluoromethyl-Phenyl Retinate-induced differentiation in human acute promyelocytic leukemia NB4 cells. Toxicol Appl Pharmacol. 2017 Mar 15;319:1-11. doi: 10.1016/j.taap.2017.01.016. Epub 2017 Jan 25.
• [507] Antitumor effect of arsenic trioxide in human K562 and K562/ADM cells by autophagy. Toxicol Mech Methods. 2012 Sep;22(7):512-9. doi: 10.3109/15376516.2012.686534. Epub 2012 May 22.
• [508] Inhibition of autophagy enhances Hydroquinone-induced TK6 cell death. Toxicol In Vitro. 2017 Jun;41:123-132. doi: 10.1016/j.tiv.2017.02.024. Epub 2017 Mar 2.
• [509] Imatinib disturbs lysosomal function and morphology and impairs the activity of mTORC1 in human hepatocyte cell lines. Food Chem Toxicol. 2022 Apr;162:112869. doi: 10.1016/j.fct.2022.112869. Epub 2022 Feb 16.
• [510] Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells. Carcinogenesis. 2005 May;26(5):883-91. doi: 10.1093/carcin/bgi036. Epub 2005 Feb 10.
• [511] Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis. Br J Cancer. 2011 Apr 12;104(8):1278-87. doi: 10.1038/bjc.2011.84.
• [512] Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells. Mol Cancer. 2011 Jul 31;10:95. doi: 10.1186/1476-4598-10-95.
• [513] The anti-cancer drug gefitinib accelerates Fas-mediated apoptosis by enhancing caspase-8 activation in cancer cells. J Toxicol Sci. 2019;44(6):435-440. doi: 10.2131/jts.44.435.
• [514] Melatonin enhances hydrogen peroxide-induced apoptosis in human promyelocytic leukaemia HL-60 cells. Mol Cell Biochem. 2011 Jul;353(1-2):167-76. doi: 10.1007/s11010-011-0783-8. Epub 2011 Mar 23.
• [515] Effect of all-trans retinoic acid on sodium/iodide symporter expression, radioiodine uptake and gene expression profiles in a human anaplastic thyroid carcinoma cell line. Nucl Med Biol. 2006 Oct;33(7):875-82. doi: 10.1016/j.nucmedbio.2006.07.004.
• [516] Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes. Toxicol In Vitro. 2021 Jun;73:105107. doi: 10.1016/j.tiv.2021.105107. Epub 2021 Feb 3.
• [517] Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
• [518] Protective role of HO-1 for alcohol-dependent liver damage. Dig Dis. 2010;28(6):792-8. doi: 10.1159/000324287. Epub 2011 Apr 27.
• [519] Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease. J Neurosci. 2016 Jun 8;36(23):6332-51. doi: 10.1523/JNEUROSCI.0426-16.2016.
• [520] Simvastatin protects dopaminergic neurons against MPP+-induced oxidative stress and regulates the endogenous anti-oxidant system through ERK. Cell Physiol Biochem. 2018;51(4):1957-1968.
• [521] P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation. Food Chem Toxicol. 2016 Feb;88:1-12. doi: 10.1016/j.fct.2015.12.004. Epub 2015 Dec 11.
• [522] Increased expression of VDAC1 sensitizes carcinoma cells to apoptosis induced by DNA cross-linking agents. Biochem Pharmacol. 2012 May 1;83(9):1172-82. doi: 10.1016/j.bcp.2012.01.017. Epub 2012 Jan 21.
• [523] Sulindac-derived reactive oxygen species induce apoptosis of human multiple myeloma cells via p38 mitogen activated protein kinase-induced mitochondrial dysfunction. Apoptosis. 2007 Jan;12(1):195-209. doi: 10.1007/s10495-006-0527-5.
• [524] Inhibition of lung cancer cell growth by quercetin glucuronides via G2/M arrest and induction of apoptosis. Drug Metab Dispos. 2006 Feb;34(2):296-304. doi: 10.1124/dmd.105.005280. Epub 2005 Nov 9.
• [525] Levamisole induced apoptosis in cultured vascular endothelial cells. Br J Pharmacol. 2000 Dec;131(8):1577-83.
• [526] Arsenic trioxide (As(2)O(3)) induced apoptosis and its mechanisms in a human esophageal squamous carcinoma cell line. Chin Med J (Engl). 2002 Feb;115(2):280-5.
• [527] Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through up-regulation of bax and bak. Carcinogenesis. 2001 Sep;22(9):1393-7. doi: 10.1093/carcin/22.9.1393.
• [528] Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol. 2008 Jun;46(6):2042-53. doi: 10.1016/j.fct.2008.01.049. Epub 2008 Feb 7.
• [529] The retinoid anticancer signal: mechanisms of target gene regulation. Br J Cancer. 2005 Aug 8;93(3):310-8. doi: 10.1038/sj.bjc.6602700.
• [530] Inhibition of fatty acid synthase expression by 1alpha,25-dihydroxyvitamin D3 in prostate cancer cells. J Steroid Biochem Mol Biol. 2003 May;85(1):1-8. doi: 10.1016/s0960-0760(03)00142-0.
• [531] Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
• [532] Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
• [533] Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
• [534] Differential responses to retinoic acid and endocrine disruptor compounds of subpopulations within human embryonic stem cell lines. Differentiation. 2012 Nov;84(4):330-43. doi: 10.1016/j.diff.2012.07.006. Epub 2012 Aug 18.
• [535] SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
• [536] The p53/miR-34a/SIRT1 Positive Feedback Loop in Quercetin-Induced Apoptosis. Cell Physiol Biochem. 2015;35(6):2192-202. doi: 10.1159/000374024. Epub 2015 Apr 7.
• [537] AMPK activator acadesine fails to alleviate isoniazid-caused mitochondrial instability in HepG2 cells. J Appl Toxicol. 2017 Oct;37(10):1219-1224. doi: 10.1002/jat.3483. Epub 2017 May 29.
• [538] Dual targeting of the antagonistic pathways mediated by Sirt1 and TXNIP as a putative approach to enhance the efficacy of anti-aging interventions. Aging (Albany NY). 2009 Mar 31;1(4):412-24. doi: 10.18632/aging.100035.
• [539] Hydroquinone-induced malignant transformation of TK6 cells by facilitating SIRT1-mediated p53 degradation and up-regulating KRAS. Toxicol Lett. 2016 Sep 30;259:133-142. doi: 10.1016/j.toxlet.2016.08.006. Epub 2016 Aug 8.
• [540] Iron overload inhibits cell proliferation and promotes autophagy via PARP1/SIRT1 signaling in endometriosis and adenomyosis. Toxicology. 2022 Jan 15;465:153050. doi: 10.1016/j.tox.2021.153050. Epub 2021 Nov 23.
• [541] Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
• [542] New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis. Arch Toxicol. 2016 Jun;90(6):1449-58.
• [543] The mitochondrial superoxide/thioredoxin-2/Ask1 signaling pathway is critically involved in troglitazone-induced cell injury to human hepatocytes. Toxicol Sci. 2008 Feb;101(2):341-9. doi: 10.1093/toxsci/kfm273. Epub 2007 Nov 1.
• [544] Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function. J Immunol. 2000 Jun 15;164(12):6287-95. doi: 10.4049/jimmunol.164.12.6287.
• [545] Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. Toxicol Appl Pharmacol. 2011 Dec 1;257(2):227-34. doi: 10.1016/j.taap.2011.09.008. Epub 2011 Sep 19.
• [546] Levodopa activates apoptosis signaling kinase 1 (ASK1) and promotes apoptosis in a neuronal model: implications for the treatment of Parkinson's disease. Chem Res Toxicol. 2011 Oct 17;24(10):1644-52. doi: 10.1021/tx200082h. Epub 2011 Aug 22.
• [547] Activation of PPAR and inhibition of cell proliferation reduces key proteins associated with the basal subtype of bladder cancer in As3+-transformed UROtsa cells. PLoS One. 2020 Aug 21;15(8):e0237976. doi: 10.1371/journal.pone.0237976. eCollection 2020.
• [548] Induction of TAp63 by histone deacetylase inhibitors. Biochem Biophys Res Commun. 2010 Jan 22;391(4):1748-51. doi: 10.1016/j.bbrc.2009.12.147. Epub 2009 Dec 30.
• [549] p63 involvement in poly(ADP-ribose) polymerase 1 signaling of topoisomerase I-dependent DNA damage in carcinoma cells. Biochem Pharmacol. 2013 Apr 1;85(7):999-1006. doi: 10.1016/j.bcp.2013.01.019. Epub 2013 Jan 29.
• [550] CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
• [551] Reactive nitrogen and oxygen species activate different sphingomyelinases to induce apoptosis in airway epithelial cells. Exp Cell Res. 2007 Jul 15;313(12):2680-6. doi: 10.1016/j.yexcr.2007.04.002. Epub 2007 Apr 6.
• [552] Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer. Cell Death Dis. 2019 Nov 7;10(11):846. doi: 10.1038/s41419-019-2001-7.
• [553] Effect of quercetin on apoptosis of PANC-1 cells. J Korean Surg Soc. 2013 Dec;85(6):249-60. doi: 10.4174/jkss.2013.85.6.249. Epub 2013 Nov 26.
• [554] Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
• [555] Isobaric tags for relative and absolute quantitation-based proteomics analysis of the effect of ginger oil on bisphenol A-induced breast cancer cell proliferation. Oncol Lett. 2021 Feb;21(2):101. doi: 10.3892/ol.2020.12362. Epub 2020 Dec 8.
• [556] Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
• [557] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [558] Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
• [559] (9)-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7-Stimulated Human Coculture. J Pharmacol Exp Ther. 2019 Oct;371(1):191-201. doi: 10.1124/jpet.119.260661. Epub 2019 Aug 5.
• [560] Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. Arch Toxicol. 2018 Jun;92(6):2043-2054. doi: 10.1007/s00204-018-2199-7. Epub 2018 Mar 29.
• [561] Spironolactone induces apoptosis in human mononuclear cells. Association between apoptosis and cytokine suppression. Apoptosis. 2006 Apr;11(4):573-9. doi: 10.1007/s10495-006-4919-3.
• [562] Effects of 25-hydroxyvitamin D(3) on proliferation and osteoblast differentiation of human marrow stromal cells require CYP27B1/1alpha-hydroxylase. J Bone Miner Res. 2011 May;26(5):1145-53.
• [563] Zoledronic acid up-regulates bone sialoprotein expression in osteoblastic cells through Rho GTPase inhibition. Biochem J. 2004 Dec 15;384(Pt 3):591-8. doi: 10.1042/BJ20040380.
• [564] Effect of surface chemical modification of bioceramic on phenotype of human bone-derived cells. J Biomed Mater Res. 1999 Mar 15;44(4):389-96. doi: 10.1002/(sici)1097-4636(19990315)44:4<389::aid-jbm4>3.0.co;2-o.
• [565] Potential osteoinductive effects of calcitriol on the m-RNA of mesenchymal stem cells derived from human alveolar periosteum. Biomed Res Int. 2016;2016:3529561.
• [566] Epigenetic control of skeletal development by the histone methyltransferase Ezh2. J Biol Chem. 2015 Nov 13;290(46):27604-17.
• [567] Cytotoxic effect of eugenol on the expression of molecular markers related to the osteogenic differentiation of human dental pulp cells. Odontology. 2011 Jul;99(2):188-92. doi: 10.1007/s10266-011-0009-2. Epub 2011 Jun 26.
• [568] Alpha ketoglutarate exerts a pro-osteogenic effect in osteoblast cell lines through activation of JNK and mTOR/S6K1/S6 signaling pathways. Toxicol Appl Pharmacol. 2019 Jul 1;374:53-64.
• [569] A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302. doi: 10.1371/journal.pone.0178302. eCollection 2017.
• [570] Translational readthrough by the aminoglycoside geneticin (G418) modulates SMN stability in vitro and improves motor function in SMA mice in vivo. Hum Mol Genet. 2009 Apr 1;18(7):1310-22. doi: 10.1093/hmg/ddp030. Epub 2009 Jan 15.
• [571] 5-Fluorouracil up-regulates interferon pathway gene expression in esophageal cancer cells. Anticancer Res. 2005 Sep-Oct;25(5):3271-8.
• [572] Cross-talk between non-genomic and genomic signalling pathways--distinct effect profiles of environmental estrogens. Toxicol Appl Pharmacol. 2010 Jun 1;245(2):160-70. doi: 10.1016/j.taap.2010.02.015. Epub 2010 Mar 4.
• [573] Differential gene expression of sulindac-treated human breast epithelial cells. Int J Oncol. 2005 Dec;27(6):1727-36.
• [574] Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin. Toxicol Mech Methods. 2017 Mar;27(3):165-172. doi: 10.1080/15376516.2016.1273424. Epub 2017 Jan 8.
• [575] PP2A-B56? complex is involved in dephosphorylation of -H2AX in the repair process of CPT-induced DNA double-strand breaks. Toxicology. 2015 May 4;331:57-65. doi: 10.1016/j.tox.2015.03.007. Epub 2015 Mar 12.
• [576] The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
• [577] Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
• [578] Molecular targeting of retinoic acid metabolism in neuroblastoma: the role of the CYP26 inhibitor R116010 in vitro and in vivo. Br J Cancer. 2007 Jun 4;96(11):1675-83.
• [579] Estrogen receptor alpha (ER)-mediated coregulator binding and gene expression discriminates the toxic ER agonist diethylstilbestrol (DES) from the endogenous ER agonist 17-estradiol (E2). Cell Biol Toxicol. 2020 Oct;36(5):417-435. doi: 10.1007/s10565-020-09516-6. Epub 2020 Feb 22.
• [580] Resveratrol-induced gene expression profiles in human prostate cancer cells. Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):596-604. doi: 10.1158/1055-9965.EPI-04-0398.
• [581] Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615. doi: 10.1007/s00204-020-02970-5. Epub 2021 Jan 29.
• [582] Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
• [583] MiR-146a affects the alteration in myeloid differentiation induced by hydroquinone in human CD34(+) hematopoietic progenitor cells and HL-60 cells. Toxicol Res (Camb). 2016 Feb 16;5(3):848-858. doi: 10.1039/c5tx00419e. eCollection 2016 May 1.
• [584] Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells. Carcinogenesis. 2006 May;27(5):916-24. doi: 10.1093/carcin/bgi312. Epub 2005 Dec 16.
• [585] Arsenic and the epigenome: interindividual differences in arsenic metabolism related to distinct patterns of DNA methylation. J Biochem Mol Toxicol. 2013 Feb;27(2):106-15. doi: 10.1002/jbt.21462. Epub 2013 Jan 11.
• [586] Analysis of estrogen agonism and antagonism of tamoxifen, raloxifene, and ICI182780 in endometrial cancer cells: a putative role for the epidermal growth factor receptor ligand amphiregulin. J Soc Gynecol Investig. 2005 Oct;12(7):e55-67.
• [587] Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid. Oncogene. 2006 Aug 28;25(38):5315-25. doi: 10.1038/sj.onc.1209679.
• [588] Retinoblastoma protein and CCAAT/enhancer-binding protein beta are required for 1,25-dihydroxyvitamin D3-induced monocytic differentiation of HL60 cells. Cancer Res. 2004 Jan 1;64(1):370-7. doi: 10.1158/0008-5472.can-03-3029.
• [589] Dual inhibition of CDK4/Rb and PI3K/AKT/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas. Leukemia. 2016 Jan;30(1):86-93. doi: 10.1038/leu.2015.185. Epub 2015 Jul 15.
• [590] Epigenetic activation of O-linked -N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia. EBioMedicine. 2020 Apr;54:102678. doi: 10.1016/j.ebiom.2020.102678. Epub 2020 Apr 6.
• [591] Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
• [592] Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
• [593] Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst Biol. 2012 Dec 10;6:152.
• [594] Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus. PLoS One. 2012;7(6):e36116. doi: 10.1371/journal.pone.0036116. Epub 2012 Jun 4.
• [595] Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134. doi: 10.1016/j.envres.2019.03.035. Epub 2019 Mar 18.
• [596] Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
• [597] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [598] Quercetin-mediated Mcl-1 and survivin downregulation restores TRAIL-induced apoptosis in non-Hodgkin's lymphoma B cells. Haematologica. 2012 Jan;97(1):38-46. doi: 10.3324/haematol.2011.046466. Epub 2011 Sep 20.
• [599] Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells. J Biol Chem. 2002 Dec 20;277(51):49504-10. doi: 10.1074/jbc.M207836200. Epub 2002 Oct 17.
• [600] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
• [601] Ouabain, a cardiac glycoside, inhibits the Fanconi anemia/BRCA pathway activated by DNA interstrand cross-linking agents. PLoS One. 2013 Oct 4;8(10):e75905. doi: 10.1371/journal.pone.0075905. eCollection 2013.
• [602] Cisplatin regulates the MAPK kinase pathway to induce increased expression of DNA repair gene ERCC1 and increase melanoma chemoresistance. Oncogene. 2012 May 10;31(19):2412-22. doi: 10.1038/onc.2011.426. Epub 2011 Sep 26.
• [603] Decreased DNA repair gene expression among individuals exposed to arsenic in United States drinking water. Int J Cancer. 2003 Apr 10;104(3):263-8. doi: 10.1002/ijc.10968.
• [604] Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial. Lancet Oncol. 2010 Nov;11(11):1057-65. doi: 10.1016/S1470-2045(10)70206-0. Epub 2010 Sep 21.
• [605] Genotoxic stress and activation of novel DNA repair enzymes in human endothelial cells and in the retinas and kidneys of streptozotocin diabetic rats. Diabetes Metab Res Rev. 2012 May;28(4):329-37. doi: 10.1002/dmrr.2279.
• [606] Bisphenol-A and estradiol exert novel gene regulation in human MCF-7 derived breast cancer cells. Mol Cell Endocrinol. 2004 Jun 30;221(1-2):47-55. doi: 10.1016/j.mce.2004.04.010.
• [607] CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
• [608] Characterization of multidrug transporter-mediated efflux of avermectins in human and mouse neuroblastoma cell lines. Toxicol Lett. 2015 Jun 15;235(3):189-98. doi: 10.1016/j.toxlet.2015.04.005. Epub 2015 Apr 9.
• [609] Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1). Biochem Pharmacol. 2004 Apr 15;67(8):1541-8.
• [610] Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis. Arthritis Rheum. 2013 Nov;65(11):2791-802.
• [611] Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression. Toxicology. 2002 Feb 28;171(2-3):137-46.
• [612] Enhanced in vitro invasiveness and drug resistance with altered gene expression patterns in a human lung carcinoma cell line after pulse selection with anticancer drugs. Int J Cancer. 2004 Sep 10;111(4):484-93. doi: 10.1002/ijc.20230.
• [613] Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
• [614] Co-encapsulation of chrysophsin-1 and epirubicin in PEGylated liposomes circumvents multidrug resistance in HeLa cells. Chem Biol Interact. 2015 Dec 5;242:13-23. doi: 10.1016/j.cbi.2015.08.023. Epub 2015 Sep 1.
• [615] Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance. Hematology. 2007 Dec;12(6):511-7. doi: 10.1080/10245330701562535.
• [616] Functional analysis of MRP1 cloned from bovine. FEBS Lett. 2002 Jun 19;521(1-3):211-3. doi: 10.1016/s0014-5793(02)02816-8.
• [617] Involvement of mitochondrial dysfunction in nefazodone-induced hepatotoxicity. Food Chem Toxicol. 2016 Aug;94:148-58. doi: 10.1016/j.fct.2016.06.001. Epub 2016 Jun 8.
• [618] Targeting of EGFR increase?anti-cancer effects of arsenic trioxide: Promising treatment for glioblastoma multiform. Eur J Pharmacol. 2018 Feb 5;820:274-285. doi: 10.1016/j.ejphar.2017.12.041. Epub 2017 Dec 20.
• [619] Aspirin and alterations in DNA repair proteins in the SW480 colorectal cancer cell line. Oncol Rep. 2010 Jul;24(1):37-46. doi: 10.3892/or_00000826.
• [620] An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment. J Biol Chem. 2008 Feb 1;283(5):2564-74. doi: 10.1074/jbc.M702454200. Epub 2007 Oct 31.
• [621] Development of human retinal organoid models for bisphenol toxicity assessment. Ecotoxicol Environ Saf. 2022 Oct 15;245:114094. doi: 10.1016/j.ecoenv.2022.114094. Epub 2022 Sep 18.
• [622] Cellular reactions to long-term volatile organic compound (VOC) exposures. Sci Rep. 2016 Dec 1;6:37842. doi: 10.1038/srep37842.
• [623] p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
• [624] Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
• [625] Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
• [626] Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. Nucleic Acids Res. 2009 Jan;37(1):78-95. doi: 10.1093/nar/gkn910. Epub 2008 Nov 16.
• [627] Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
• [628] Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
• [629] The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
• [630] Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
• [631] Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis. Oncogene. 2010 Mar 4;29(9):1329-38. doi: 10.1038/onc.2009.425. Epub 2009 Nov 30.
• [632] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [633] Characterization of the Molecular Alterations Induced by the Prolonged Exposure of Normal Colon Mucosa and Colon Cancer Cells to Low-Dose Bisphenol A. Int J Mol Sci. 2022 Oct 1;23(19):11620. doi: 10.3390/ijms231911620.
• [634] Taurine-responsive genes related to signal transduction as identified by cDNA microarray analyses of HepG2 cells. J Med Food. 2006 Spring;9(1):33-41. doi: 10.1089/jmf.2006.9.33.
• [635] Noncoding RNA synthesis and loss of Polycomb group repression accompanies the colinear activation of the human HOXA cluster. RNA. 2007 Feb;13(2):223-39. doi: 10.1261/rna.266707. Epub 2006 Dec 21.
• [636] The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. Hum Reprod. 2010 Nov;25(11):2859-69.
• [637] Evaluation of developmental toxicity using undifferentiated human embryonic stem cells. J Appl Toxicol. 2015 Feb;35(2):205-18.
• [638] BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell. 2011 Sep 16;146(6):904-17.
• [639] Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
• [640] Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environ Health Perspect. 2008 Apr;116(4):524-31. doi: 10.1289/ehp.10861.
• [641] Activation of p44/42 in human natural killer cells decreases cell-surface protein expression: Relationship to tributyltin-induced alterations of protein expression. Toxicol Mech Methods. 2010 Nov;20(9):544-55. doi: 10.3109/15376516.2010.518174. Epub 2010 Sep 30.
• [642] Identification of potential biomarkers of hepatitis B-induced acute liver failure using hepatic cells derived from human skin precursors. Toxicol In Vitro. 2015 Sep;29(6):1231-9. doi: 10.1016/j.tiv.2014.10.012. Epub 2014 Oct 24.
• [643] Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
• [644] Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis. Biol Reprod. 2011 Apr;84(4):801-15.
• [645] Molecular mechanisms of resveratrol action in lung cancer cells using dual protein and microarray analyses. Cancer Res. 2007 Dec 15;67(24):12007-17. doi: 10.1158/0008-5472.CAN-07-2464.
• [646] Effects of Se-depletion on glutathione peroxidase and selenoprotein W gene expression in the colon. FEBS Lett. 2005 Jan 31;579(3):792-6. doi: 10.1016/j.febslet.2004.12.042.
• [647] Fumarate hydratase inactivation in hereditary leiomyomatosis and renal cell cancer is synthetic lethal with ferroptosis induction. Cancer Sci. 2018 Sep;109(9):2757-2766. doi: 10.1111/cas.13701. Epub 2018 Jul 20.
• [648] Chronic cyclophosphamide exposure alters the profile of rat sperm nuclear matrix proteins. Biol Reprod. 2007 Aug;77(2):303-11. doi: 10.1095/biolreprod.107.060244. Epub 2007 May 2.
• [649] Role of oxidative stress in the induction of metallothionein-2A and heme oxygenase-1 gene expression by the antineoplastic agent gallium nitrate in human lymphoma cells. Free Radic Biol Med. 2008 Sep 15;45(6):763-72.
• [650] Trabectedin induces ferroptosis via regulation of HIF-1/IRP1/TFR1 and Keap1/Nrf2/GPX4 axis in non-small cell lung cancer cells. Chem Biol Interact. 2023 Jan 5;369:110262. doi: 10.1016/j.cbi.2022.110262. Epub 2022 Nov 14.
• [651] Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death. Mol Pharmacol. 2005 May;67(5):1808-17. doi: 10.1124/mol.104.005769. Epub 2005 Feb 9.
• [652] Role of BAX in the apoptotic response to anticancer agents. Science. 2000 Nov 3;290(5493):989-92. doi: 10.1126/science.290.5493.989.
• [653] Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. Int J Cancer. 2008 Aug 15;123(4):951-7. doi: 10.1002/ijc.23593.
• [654] Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines. Toxicol Appl Pharmacol. 2010 Nov 15;249(1):91-100.
• [655] Reversal of multidrug resistance of vincristine-resistant gastric adenocarcinoma cells through up-regulation of DARPP-32. Cell Biol Int. 2007 Sep;31(9):1010-5. doi: 10.1016/j.cellbi.2007.03.020. Epub 2007 Mar 21.
• [656] Comprehensive transcriptome profiling of BET inhibitor-treated HepG2 cells. PLoS One. 2022 Apr 29;17(4):e0266966. doi: 10.1371/journal.pone.0266966. eCollection 2022.
• [657] ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis. J Biol Chem. 2006 Sep 29;281(39):28764-71. doi: 10.1074/jbc.M604392200. Epub 2006 Aug 3.
• [658] Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J Biol Chem. 2012 Apr 20;287(17):14289-300. doi: 10.1074/jbc.M112.353201. Epub 2012 Mar 1.
• [659] Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
• [660] Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2716-23.
• [661] Prevention of deoxycholate-induced gastric apoptosis by aspirin: roles of NF-kappaB and PKC signaling. J Surg Res. 2008 Mar;145(1):66-73. doi: 10.1016/j.jss.2007.04.039. Epub 2007 Jul 20.
• [662] Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells. Immunology. 2007 May;121(1):71-81. doi: 10.1111/j.1365-2567.2006.02539.x.
• [663] Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells. Eur J Pharmacol. 2010 Jun 10;635(1-3):219-26. doi: 10.1016/j.ejphar.2010.02.044. Epub 2010 Mar 20.
• [664] Distinct genetic profile in peripheral blood mononuclear cells of psoriatic arthritis patients treated with methotrexate and TNF-inhibitors. Clin Rheumatol. 2014 Dec;33(12):1815-21. doi: 10.1007/s10067-014-2807-8. Epub 2014 Oct 24.
• [665] Ultradian cortisol pulsatility encodes a distinct, biologically important signal. PLoS One. 2011 Jan 18;6(1):e15766.
• [666] Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
• [667] Artemin is estrogen regulated and mediates antiestrogen resistance in mammary carcinoma. Oncogene. 2010 Jun 3;29(22):3228-40. doi: 10.1038/onc.2010.71. Epub 2010 Mar 22.
• [668] Rosiglitazone sensitizes MDA-MB-231 breast cancer cells to anti-tumour effects of tumour necrosis factor-alpha, CH11 and CYC202. Endocr Relat Cancer. 2007 Jun;14(2):305-15. doi: 10.1677/ERC-06-0003.
• [669] Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
• [670] Effect of benzo[a]pyrene on proliferation and metastasis of oral squamous cell carcinoma cells: A transcriptome analysis based on RNA-seq. Environ Toxicol. 2022 Nov;37(11):2589-2604. doi: 10.1002/tox.23621. Epub 2022 Jul 23.