Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGDA3C)

• Drug Name: cycloheximide Drug Info
• Synonyms: naramycin A; NSC 185; FT 3422-2; NM-MCD 80

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 6197
  ChEBI ID: CHEBI:27641
  CAS Number: CAS 66-81-9
  TTD Drug ID: DMGDA3C
  VARIDT Drug ID: DR01367

Molecule-Related Drug Atlas

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[9]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[10]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[11]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[12]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[11]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[13]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[11]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[14]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[15]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[16]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[17]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[18]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[19]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[20]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[21]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[22]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[23]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[24]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[22]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[25]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[27]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[28]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[31]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[32]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[33]

Drug(s) Affected By ATP-binding cassette sub-family C member 5 (ABCC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[35]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[36]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[38]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]

Drug(s) Affected By Transforming acidic coiled-coil-containing protein 1 (TACC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[47]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[48]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]

Drug(s) Affected By Trefoil factor 1 (TFF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[50]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[55]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[56]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[57]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[60]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[5]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[61]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]

Drug(s) Affected By Amphiregulin (AREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[73]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[74]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[76]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[77]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[78]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[81]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]

Drug(s) Affected By Insulin-like growth factor-binding protein 4 (IGFBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[84]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[75]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[88]

Drug(s) Affected By Insulin receptor substrate 1 (IRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[5]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[92]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]

Drug(s) Affected By CCN family member 3 (CCN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[98]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[5]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[100]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[101]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[102]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[103]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[104]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[105]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[106]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[107]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[109]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[110]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[113]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[114]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[115]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[118]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[119]

Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[120]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[122]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[111]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[122]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[124]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[122]

Drug(s) Affected By Dynamin-1-like protein (DNM1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[46]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[131]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[127]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[133]

Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[139]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[46]

Drug(s) Affected By Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[47]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[142]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[144]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[145]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[146]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[147]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[146]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[146]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[150]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[146]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[152]
Selenium	DM25CGV	N. A.	N. A.	Approved	[153]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[154]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[155]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[156]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[159]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[162]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[163]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[164]

Drug(s) Affected By Protein kinase C beta type (PRKCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[165]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[168]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[169]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[165]

Drug(s) Affected By Glia-derived nexin (SERPINE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[90]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[46]

Drug(s) Affected By ETS domain-containing protein Elk-1 (ELK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[171]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[174]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[176]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By Pleiotrophin (PTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[178]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[179]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[180]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[43]
Chondroitin sulfate	DM0N19Y	N. A.	N. A.	Phase 4	[181]

Drug(s) Affected By CCN family member 2 (CCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[184]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[185]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[90]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[186]

Drug(s) Affected By Kappa-type opioid receptor (OPRK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[187]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[188]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[189]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[43]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[190]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[58]

Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[191]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[192]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[191]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[81]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[194]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[192]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[196]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[198]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[46]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[199]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[180]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[201]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[202]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[203]

Drug(s) Affected By Single-stranded DNA-binding protein, mitochondrial (SSBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[204]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[46]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]

Drug(s) Affected By Oxysterols receptor LXR-alpha (NR1H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[208]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[209]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[210]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[209]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[211]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[212]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[213]

Drug(s) Affected By Mitogen-activated protein kinase 7 (MAPK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[214]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[215]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[216]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[180]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[217]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[217]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]

Drug(s) Affected By Pappalysin-1 (PAPPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[218]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[220]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[221]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[222]

Drug(s) Affected By SERTA domain-containing protein 2 (SERTAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[168]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[47]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[224]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[180]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]

Drug(s) Affected By Next to BRCA1 gene 1 protein (NBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[225]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[176]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[226]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[227]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[47]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[228]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[102]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[229]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[230]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[231]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[232]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[233]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[234]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[235]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[236]

Drug(s) Affected By 5'-3' exonuclease PLD3 (PLD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[46]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[220]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[238]

Drug(s) Affected By Synaptopodin (SYNPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[188]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[215]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[180]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[239]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[237]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[240]

Drug(s) Affected By Transmembrane protein 263 (TMEM263)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Bortezomib	DMNO38U	Leukemia		Approved	[176]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[47]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[215]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[203]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[241]

Drug(s) Affected By Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[179]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[242]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[243]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[203]
EMODIN	DMAEDQG	Coronavirus Disease 2019 (COVID-19)	1D6Y	Terminated	[244]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[141]

Drug(s) Affected By Sororin (CDCA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[245]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[246]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[248]

Drug(s) Affected By Retinoic acid receptor responder protein 2 (RARRES2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[249]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[220]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[250]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[251]

Drug(s) Affected By Solute carrier family 22 member 4 (SLC22A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levacecarnine hci	DMJBOCR	Cognitive impairment	6D71	Approved	[252]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[253]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[254]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[255]

Drug(s) Affected By CDC42 small effector protein 2 (CDC42SE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Bortezomib	DMNO38U	Leukemia		Approved	[176]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[47]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[237]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[145]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[256]

Drug(s) Affected By Myotubularin-related protein 7 (MTMR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[203]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[257]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[258]

Drug(s) Affected By Small ribosomal subunit protein uS7m (MRPS7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[214]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[202]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[259]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[260]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[261]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[262]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[263]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[264]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[264]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[265]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[266]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[267]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[268]

Drug(s) Affected By Cytochrome P450 2A6 (CYP2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tegafur	DM31ZQM	Solid tumour/cancer	2A00-2F9Z	Approved	[269]
Methoxsalen	DME8FZ9	Cutaneous T-cell lymphoma	2B01	Approved	[270]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[272]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[273]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[274]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[275]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[208]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[276]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[277]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[278]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[170]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[253]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[279]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[280]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[279]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[75]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[281]

Drug(s) Affected By NADPH--cytochrome P450 reductase (POR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[180]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[282]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[284]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]

Drug(s) Affected By Tumor protein p53-inducible protein 11 (TP53I11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[285]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[286]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[188]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[287]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[238]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[288]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[214]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[290]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[291]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[289]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[294]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[294]

Drug(s) Affected By Transcription regulator protein BACH1 (BACH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[295]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[296]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[280]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[298]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]

Drug(s) Affected By Proepiregulin (EREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[245]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[146]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[146]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[146]

Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[299]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[300]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[301]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[302]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[303]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[305]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[306]

Drug(s) Affected By Autophagy-related protein 13 (ATG13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[307]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[308]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[256]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[257]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[309]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[186]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[170]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[218]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[90]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[310]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[311]

Drug(s) Affected By Mitochondrial uncoupling protein 4 (SLC25A27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[312]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[224]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[145]
4-hydroxy-2-nonenal	DM2LJFZ	Discovery agent	N.A.	Investigative	[313]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[314]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[315]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[316]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[317]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[318]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[319]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[320]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Selenium	DM25CGV	N. A.	N. A.	Approved	[321]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[71]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[322]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[323]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[156]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[323]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[324]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[325]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[326]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[327]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[327]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[328]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[329]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[330]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[86]

Drug(s) Affected By Protransforming growth factor alpha (TGFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[111]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[111]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[331]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[332]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[92]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[333]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[334]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[335]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[336]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[337]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[338]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[339]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[340]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[341]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[342]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[343]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[344]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[318]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[345]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[346]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[347]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[344]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[348]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[349]
Selenium	DM25CGV	N. A.	N. A.	Approved	[153]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[184]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[350]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[351]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[352]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[353]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[330]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[354]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[355]

Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[356]
Ademetionine	DMYQDBO	Hepatic fibrosis	DB93.0	Approved	[357]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[58]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[358]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[359]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[273]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[360]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[58]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[361]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[184]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[362]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[236]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[363]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[147]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[152]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[364]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[184]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[365]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[365]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[366]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[367]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[368]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[369]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[370]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[371]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[372]

Drug(s) Affected By Transcription factor AP-2-alpha (TFAP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[373]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[374]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[375]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[373]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[225]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[56]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[281]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[281]

Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[376]
Bambuterol	DMKLSHF	Asthma	CA23	Approved	[377]
Terbutaline	DMD4381	Asthma	CA23	Approved	[378]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[379]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[380]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[381]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[382]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[383]

Drug(s) Affected By Rho-related GTP-binding protein RhoC (RHOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[384]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[385]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[386]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[311]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[387]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[46]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[388]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[389]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[390]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[391]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[392]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[391]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[393]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[394]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[395]

Drug(s) Affected By Intestinal-type alkaline phosphatase (ALPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[396]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[397]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[397]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[398]
Wortmannin	DM8EVK5	Haematological malignancy	2B33.Y	Terminated	[396]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[256]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[257]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[399]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[400]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[401]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[402]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[403]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[236]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[404]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[405]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[146]

Drug(s) Affected By E3 SUMO-protein ligase EGR2 (EGR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[407]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[176]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By Steroid hormone receptor ERR1 (ESRRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[408]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[409]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[410]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[411]
Bortezomib	DMNO38U	Leukemia		Approved	[176]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[412]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[413]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[413]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[242]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[363]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[111]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[414]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[147]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[337]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[415]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[372]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[416]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[417]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[418]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[419]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[420]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[421]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[422]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[423]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[424]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[425]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[426]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[156]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[427]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[428]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[429]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[430]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[431]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-3 (ERBB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[111]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[432]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[433]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[434]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[435]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[58]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[436]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[349]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[437]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[438]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[33]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[169]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[439]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[440]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[441]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[442]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[443]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[444]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[445]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[446]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[447]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[448]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[449]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[440]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[450]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[451]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[452]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[439]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[442]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[443]

Drug(s) Affected By Retinoblastoma-like protein 1 (RBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[453]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[454]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[246]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]

Drug(s) Affected By Protein PML (PML)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[455]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[353]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[355]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[353]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[46]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[456]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[457]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[457]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[458]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[459]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[460]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[461]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[462]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[463]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[464]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[465]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[466]

Drug(s) Affected By Pro-adrenomedullin (ADM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[322]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[467]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[425]

Drug(s) Affected By Receptor-type tyrosine-protein kinase FLT3 (FLT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[468]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[469]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[257]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[470]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[471]
Venetoclax	DM8I94Y	Chronic lymphocytic leukaemia	2A82.0	Approved	[472]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[473]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[474]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[475]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[476]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[322]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[418]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[477]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[478]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[479]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[480]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[392]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[289]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[481]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[482]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[483]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[484]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[485]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[486]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[487]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[488]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[489]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[436]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[480]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[490]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[491]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[492]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[493]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[494]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[495]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF4 (RNF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[496]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[251]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[180]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[497]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[202]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[256]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[220]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[498]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[499]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[456]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[500]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[501]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[502]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[503]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[238]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[504]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[505]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[505]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[506]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[507]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[505]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[505]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[505]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[505]

Drug(s) Affected By Urokinase plasminogen activator surface receptor (PLAUR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[508]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[509]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[510]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[286]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[511]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[246]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[196]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[461]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[455]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[431]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[169]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[512]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[513]

Drug(s) Affected By Recombining binding protein suppressor of hairless (RBPJ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[257]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[500]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[514]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[515]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[48]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[48]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[516]

Drug(s) Affected By Tight junction protein ZO-1 (TJP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[517]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[214]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[46]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[518]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[519]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[460]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[520]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[390]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[521]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[522]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[303]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[106]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[442]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[299]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[523]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[301]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[524]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[525]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[299]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[526]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[306]

Drug(s) Affected By TAR DNA-binding protein 43 (TARDBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[527]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[75]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[528]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[93]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[529]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[530]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Hexachlorophene	DMLKSE0	Bacterial infection	1A00-1C4Z	Approved	[531]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[334]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[532]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[533]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[534]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[535]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[278]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[536]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[537]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[538]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[539]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[540]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[390]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[541]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[542]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[543]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[296]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[544]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[350]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[545]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[546]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[547]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[548]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[548]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[549]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[550]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[551]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[525]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[552]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[553]

Drug(s) Affected By Protein NDRG1 (NDRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[147]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[554]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[455]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[555]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[226]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By Type II iodothyronine deiodinase (DIO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[556]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[557]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[558]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[184]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[559]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[560]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By Sodium/iodide cotransporter (SLC5A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[561]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[562]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[563]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[564]
Tazarotene	DM8SMD1	Acne vulgaris	ED80	Approved	[565]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[565]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[565]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[566]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[567]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[565]

Drug(s) Affected By Transcription termination factor 3, mitochondrial (MTERF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[180]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[142]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[448]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[278]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[568]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[569]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[570]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[571]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[572]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[225]
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[573]

Drug(s) Affected By Proheparin-binding EGF-like growth factor (HBEGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[574]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[575]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[576]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[576]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[90]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[246]

Drug(s) Affected By Endothelial PAS domain-containing protein 1 (EPAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[534]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[577]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[578]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ketorolac	DMI4EL5	Postoperative inflammation	1A00-CA43.1	Approved	[578]

Drug(s) Affected By Repressor of RNA polymerase III transcription MAF1 homolog (MAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[273]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[224]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
MLN4924	DMP36KD	Myelodysplastic syndrome	2A37	Phase 3	[579]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[203]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[145]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[256]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[256]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[580]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[581]
Fructose	DM43AN2	Vomiting	MD90	Approved	[58]
Ketoprofen	DMRKXPT	Bursitis		Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[582]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[442]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[583]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[584]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[585]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[147]

Drug(s) Affected By MAP kinase-activated protein kinase 3 (MAPKAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[586]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[284]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[586]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]

Drug(s) Affected By D-ribitol-5-phosphate cytidylyltransferase (CRPPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[587]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[398]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[145]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[257]

Drug(s) Affected By Rab9 effector protein with kelch motifs (RABEPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[214]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[273]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[224]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[588]

Drug(s) Affected By Kremen protein 1 (KREMEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[246]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Haloperidol	DM96SE0	Delirium		Approved	[589]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[590]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[238]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[180]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[43]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[591]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[492]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[592]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[484]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[593]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[594]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[460]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[595]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[596]

Drug(s) Affected By Unconventional myosin-Id (MYO1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[246]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[215]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[250]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[143]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]

Drug(s) Affected By Cation channel sperm-associated protein 4 (CATSPER4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[203]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[257]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5'-3' exonuclease PLD3 (PLD3)	OTL07SP2	PLD3_HUMAN	Gene/Protein Processing	[3]
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1)	OTGND2YZ	SIA8A_HUMAN	Gene/Protein Processing	[3]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Gene/Protein Processing	[4]
Amphiregulin (AREG)	OTJFOR67	AREG_HUMAN	Gene/Protein Processing	[5]
Apoptotic protease-activating factor 1 (APAF1)	OTJWIVY0	APAF_HUMAN	Gene/Protein Processing	[3]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Gene/Protein Processing	[6]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Gene/Protein Processing	[7]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Gene/Protein Processing	[5]
ATP-binding cassette sub-family C member 5 (ABCC5)	OT34G4US	MRP5_HUMAN	Gene/Protein Processing	[5]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[8]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5433).
• [2] Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomedicine. 2012 Aug 15;19(11):977-87.
• [3] Comparative analysis of AhR-mediated TCDD-elicited gene expression in human liver adult stem cells. Toxicol Sci. 2009 Nov;112(1):229-44.
• [4] Aryl hydrocarbon receptor-dependent up-regulation of the heterodimeric amino acid transporter LAT1 (SLC7A5)/CD98hc (SLC3A2) by diesel exhaust particle extract in human bronchial epithelial cells. Toxicol Appl Pharmacol. 2016 Jan 1;290:74-85.
• [5] Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
• [6] Novel sulfonanilide analogues suppress aromatase expression and activity in breast cancer cells independent of COX-2 inhibition. J Med Chem. 2006 Feb 23;49(4):1413-9.
• [7] Superinduction of CYP1A1 in MCF10A cultures by cycloheximide, anisomycin, and puromycin: a process independent of effects on protein translation and unrelated to suppression of aryl hydrocarbon receptor proteolysis by the proteasome. Mol Pharmacol. 2004 Oct;66(4):936-47.
• [8] A structure-function relationship among reserpine and yohimbine analogues in their ability to increase expression of mdr1 and P-glycoprotein in a human colon carcinoma cell line. Mol Pharmacol. 1995 Oct;48(4):682-9.
• [9] Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
• [10] MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
• [11] Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
• [12] Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
• [13] Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
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