Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKL9QO)

• Drug Name: Seocalcitol Drug Info
• Synonyms: Seocalcitol; 134404-52-7; UNII-Q0OZ0D9223; EB-1089; Q0OZ0D9223; EB1089; EB 1089; Seocalcitol [INN:BAN]; CB-1089; (22E,24E)-1alpha,25-dihydroxy-26,27-dimethyl-22,23,24,24a-tetradehydro-24a-homovitamin D3 / (22E,24E)-1alpha,25-dihydroxy-26,27-dimethyl-22,23,24,24a-tetradehydro-24a-homocholecalciferol; (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,3E,5E)-7-ethyl-7-hydroxynona-3,5-dien-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol

Indication

Disease Entry	ICD 11	Status	REF
Rickets	5B57	Phase 3	[1]

• Cross-matching ID:
  PubChem CID: 5288149
  CAS Number: CAS 134404-52-7
  TTD Drug ID: DMKL9QO

Molecule-Related Drug Atlas

Drug(s) Targeting Vitamin D3 receptor (VDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[5]
Calcidiol	DMN4CV5	Hypophosphatemia		Approved	[4]
Doxercalciferol	DM6FG1P	Chronic kidney disease	GB61	Approved	[6]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[7]
Falecalcitrol	DMBI9ZJ	Hyperparathyroidism	5A51	Approved	[8]
Dihydrotachysterol	DMFB97P	Hypocalcemia	5B5K.1	Approved	[9]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[10]
Paricalcitol	DMYBV3G	Hyperparathyroidism	5A51	Approved	[11]
S-06911	DMAYTIH	Osteoporosis	FB83.0	Phase 3	[12]

Drug(s) Affected By ATP-dependent RNA helicase DDX39A (DDX39A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[13]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[20]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[21]

Drug(s) Affected By Galectin-9 (LGALS9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[16]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[26]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[27]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF103 (RNF103)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[13]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[29]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[16]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[33]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[34]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[35]

Drug(s) Affected By cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[40]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[41]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[42]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[43]

Drug(s) Affected By CCN family member 1 (CCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[46]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]

Drug(s) Affected By Actin-binding LIM protein 1 (ABLIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[52]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[54]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[55]

Drug(s) Affected By Inositol polyphosphate 4-phosphatase type II (INPP4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[58]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[29]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[26]

Drug(s) Affected By Carbonic anhydrase 2 (CA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[61]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[63]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[64]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[65]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]

Drug(s) Affected By C-X-C motif chemokine 10 (CXCL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[70]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]

Drug(s) Affected By Metallothionein-2 (MT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[80]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[81]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[82]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[84]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[85]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[86]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]

Drug(s) Affected By Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[93]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[33]

Drug(s) Affected By Protein S100-A8 (S100A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[95]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[98]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[95]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[95]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]

Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[101]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[86]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[104]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[105]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[106]

Drug(s) Affected By Neuroendocrine protein 7B2 (SCG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[108]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[109]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[110]

Drug(s) Affected By Transcription factor AP-2-alpha (TFAP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[111]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[112]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[111]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[29]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[115]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[81]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[81]

Drug(s) Affected By Keratin, type II cytoskeletal 8 (KRT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[116]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[118]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[116]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Calbindin (CALB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[122]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[125]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[40]

Drug(s) Affected By Protein S100-A9 (S100A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[95]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[127]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[98]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]

Drug(s) Affected By Neurofilament light polypeptide (NEFL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[96]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[129]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[96]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[130]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[130]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[130]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[130]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[132]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[85]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[134]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[89]

Drug(s) Affected By Inhibin beta A chain (INHBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[52]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[137]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[138]

Drug(s) Affected By Monocyte differentiation antigen CD14 (CD14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[139]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[140]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[143]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]

Drug(s) Affected By U1 small nuclear ribonucleoprotein C (SNRPC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[145]

Drug(s) Affected By Fructose-1,6-bisphosphatase 1 (FBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[146]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[148]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[149]

Drug(s) Affected By Pro-cathepsin H (CTSH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[153]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[154]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[45]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[58]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[156]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[157]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[3]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]

Drug(s) Affected By Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[158]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[160]
Fructose	DM43AN2	Vomiting	MD90	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[163]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[164]

Drug(s) Affected By Choriogonadotropin subunit beta 7 (CGB7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[109]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[166]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[167]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[168]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[170]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[171]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[172]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[175]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[173]

Drug(s) Affected By Osteopontin (SPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[176]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[178]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[180]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[182]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[183]

Drug(s) Affected By COUP transcription factor 1 (NR2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[29]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[185]

Drug(s) Affected By Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[186]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[187]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[188]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]

Drug(s) Affected By Glucose-6-phosphate 1-dehydrogenase (G6PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[130]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[189]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[192]

Drug(s) Affected By Parathyroid hormone-related protein (PTHLH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[193]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[196]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[197]

Drug(s) Affected By Protein L-Myc (MYCL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[193]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[58]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[29]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[198]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[199]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]

Drug(s) Affected By Bone morphogenetic protein 2 (BMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[203]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[60]

Drug(s) Affected By Interferon-induced transmembrane protein 1 (IFITM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[193]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]

Drug(s) Affected By Bone morphogenetic protein 1 (BMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[208]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[209]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[33]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[43]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[210]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[213]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[70]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[214]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[215]

Drug(s) Affected By Prolyl 4-hydroxylase subunit alpha-1 (P4HA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[81]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[81]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[60]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[82]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[217]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Selenium	DM25CGV	N. A.	N. A.	Approved	[218]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[219]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[220]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[221]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[222]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[223]

Drug(s) Affected By Amphiregulin (AREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[224]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[193]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[112]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[227]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[228]

Drug(s) Affected By Membrane cofactor protein (CD46)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
ABIRATERONE	DM8V75C	Prostate cancer	2C82.0	Approved	[229]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[229]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[33]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[231]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[232]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[233]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[235]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[236]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[237]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]

Drug(s) Affected By Epithelial cell adhesion molecule (EPCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[239]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[240]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[241]

Drug(s) Affected By Interleukin-7 receptor subunit alpha (IL7R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[242]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[243]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[98]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[29]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[135]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[244]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[245]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[171]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[139]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[246]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[247]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[78]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[248]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[249]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 1 (PTPN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[250]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[251]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[252]
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[253]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[254]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[255]

Drug(s) Affected By Cadherin-2 (CDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[246]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[256]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[257]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[258]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[259]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[260]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[261]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[129]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[262]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[217]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[263]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[264]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[265]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[223]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[46]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[266]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]

Drug(s) Affected By Midkine (MDK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[267]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[209]

Drug(s) Affected By Bone morphogenetic protein 6 (BMP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[173]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[173]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[173]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[173]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[173]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[173]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[215]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[173]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]

Drug(s) Affected By Glutathione peroxidase 3 (GPX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[268]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[140]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[269]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[270]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[271]

Drug(s) Affected By Galanin peptides (GAL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[272]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[272]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[16]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[272]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]

Drug(s) Affected By Cytochrome P450 3A7 (CYP3A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[273]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[274]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[275]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[276]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[277]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[278]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[279]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[140]

Drug(s) Affected By Tenascin (TNC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[280]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[256]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[256]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[281]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[282]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By G0/G1 switch protein 2 (G0S2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Selenium	DM25CGV	N. A.	N. A.	Approved	[283]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[284]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[285]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[286]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]

Drug(s) Affected By Calmodulin-like protein 3 (CALML3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[46]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[27]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[288]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[248]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[289]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[290]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[29]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[291]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]

Drug(s) Affected By DNA excision repair protein ERCC-5 (ERCC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[222]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[292]
Ximelegatran	DMU8ANS	Myocardial infarction	BA41-BA43	Approved	[293]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[294]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[295]

Drug(s) Affected By Adenosine receptor A2b (ADORA2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[296]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[109]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[199]

Drug(s) Affected By Cellular retinoic acid-binding protein 2 (CRABP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[297]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[298]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[297]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[299]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[300]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]

Drug(s) Affected By Caspase-1 (CASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[301]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[303]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[304]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[305]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[306]

Drug(s) Affected By Serpin B3 (SERPINB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[307]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[197]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[308]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[27]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[308]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[308]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[309]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[309]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[153]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[310]

Drug(s) Affected By Transmembrane 4 L6 family member 1 (TM4SF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[13]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[311]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]

Drug(s) Affected By Leukocyte elastase inhibitor (SERPINB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[312]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[313]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[249]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[314]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]

Drug(s) Affected By Transcription factor HIVEP2 (HIVEP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[315]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[198]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[316]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]

Drug(s) Affected By Desmoglein-3 (DSG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[193]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[115]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[317]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[43]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[318]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[318]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[318]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[27]
Chlorogenic acid	DM2Y3P4	Discovery agent	N.A.	Investigative	[318]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[319]

Drug(s) Affected By Lymphocyte-specific protein 1 (LSP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[198]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]

Drug(s) Affected By Cyclin-dependent kinases regulatory subunit 2 (CKS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[227]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[16]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[315]

Drug(s) Affected By G protein-coupled receptor kinase 5 (GRK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[270]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[310]

Drug(s) Affected By Prohibitin 1 (PHB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[189]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[246]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[249]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[321]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[320]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[322]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[323]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[324]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[325]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[326]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[327]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[328]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[329]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[330]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM23 (TRIM23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[331]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[40]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[33]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[332]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[333]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[197]

Drug(s) Affected By 17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[334]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[334]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[335]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[58]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[336]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[3]

Drug(s) Affected By Nicotinamide N-methyltransferase (NNMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[315]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[337]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[338]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[189]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[189]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[20]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[339]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[54]

Drug(s) Affected By Cyclin-F (CCNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[340]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[227]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[341]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[16]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]

Drug(s) Affected By B-cell lymphoma 6 protein (BCL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[343]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[343]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[343]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[198]
Bortezomib	DMNO38U	Leukemia		Approved	[208]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]

Drug(s) Affected By Regulator of G-protein signaling 2 (RGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[46]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[344]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[29]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]

Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[345]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[67]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[346]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[347]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[346]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[346]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[33]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[348]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[349]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[350]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[350]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[348]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[348]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[351]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[352]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]

Drug(s) Affected By ETS translocation variant 4 (ETV4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[193]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[3]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Bortezomib	DMNO38U	Leukemia		Approved	[208]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]

Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[353]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[354]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[353]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[46]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[355]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[356]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[357]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[354]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[129]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[3]

Drug(s) Affected By Radiation-inducible immediate-early gene IEX-1 (IER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[246]
Selenium	DM25CGV	N. A.	N. A.	Approved	[283]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[343]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[58]

Drug(s) Affected By Retinaldehyde dehydrogenase 3 (ALDH1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[130]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[358]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[357]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[16]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[81]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[81]

Drug(s) Affected By Nuclear receptor-interacting protein 1 (NRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[359]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[360]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[361]

Drug(s) Affected By Nuclear pore complex protein Nup153 (NUP153)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[13]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[362]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[189]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]

Drug(s) Affected By Selenoprotein P (SELENOP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[58]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[359]

Drug(s) Affected By Epithelial membrane protein 2 (EMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[363]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[54]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[365]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[366]

Drug(s) Affected By Epithelial membrane protein 3 (EMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[297]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[367]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[297]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]

Drug(s) Affected By GTP-binding protein GEM (GEM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[368]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[369]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[197]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[60]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]

Drug(s) Affected By Myeloid leukemia factor 1 (MLF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[270]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[370]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[365]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[371]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[365]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[27]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[210]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP1B (FKBP1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[270]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[372]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[199]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[373]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[373]

Drug(s) Affected By Cyclin-A1 (CCNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[58]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[374]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[320]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[375]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[376]

Drug(s) Affected By Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[193]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[180]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[109]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[377]

Drug(s) Affected By Runt-related transcription factor 1 (RUNX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[13]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[81]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[81]
Cotinine	DMCEZ1B	Insecticide	N.A.	Approved	[378]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]

Drug(s) Affected By Interferon-induced transmembrane protein 2 (IFITM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[193]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[379]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[379]

Drug(s) Affected By Interleukin-1 receptor-like 1 (IL1RL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[153]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[380]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[381]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[34]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[382]

Drug(s) Affected By Transgelin (TAGLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[383]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[132]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[384]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[383]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[383]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[383]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[386]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[384]

Drug(s) Affected By Collagen alpha-1(VII) chain (COL7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[280]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[46]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[243]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[387]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]

Drug(s) Affected By Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (GCNT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[388]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[310]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[389]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[366]

Drug(s) Affected By Dystonin (DST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[13]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[359]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[375]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[390]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[348]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[349]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[391]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[348]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[348]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[46]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[392]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[391]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[348]

Drug(s) Affected By GA-binding protein subunit beta-1 (GABPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[393]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[379]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[379]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[393]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[394]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[27]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[210]

Drug(s) Affected By 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[369]
Calcidiol	DMN4CV5	Hypophosphatemia		Approved	[395]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[396]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[397]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[398]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[399]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[400]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[16]

Drug(s) Affected By Forkhead box protein M1 (FOXM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[401]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[223]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[357]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[16]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[402]

Drug(s) Affected By Transcriptional activator MN1 (MN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[403]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[281]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[33]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[371]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[43]

Drug(s) Affected By A-kinase anchor protein 13 (AKAP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[315]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[404]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[405]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[406]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[366]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[33]

Drug(s) Affected By EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[20]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[45]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[45]

Drug(s) Affected By Follistatin-related protein 1 (FSTL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[13]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[284]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[407]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[33]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[246]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[46]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[78]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[408]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[409]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[49]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[29]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[81]

Drug(s) Affected By MAL-like protein (MALL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[385]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[20]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[410]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[411]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[412]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[413]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[414]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[27]

Drug(s) Affected By Pregnancy-specific beta-1-glycoprotein 7 (PSG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[215]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[415]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[27]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[416]

Drug(s) Affected By Semaphorin-3B (SEMA3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[13]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[417]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[418]

Drug(s) Affected By Semaphorin-3F (SEMA3F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[419]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[152]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]

Drug(s) Affected By Inactive tyrosine-protein kinase 7 (PTK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[189]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[40]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[27]

Drug(s) Affected By Integrin alpha-7 (ITGA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[246]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[420]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[421]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[422]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[33]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[43]

Drug(s) Affected By Krueppel-like factor 9 (KLF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[156]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[156]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[424]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]

Drug(s) Affected By Cyclic nucleotide-gated cation channel beta-1 (CNGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[91]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[425]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[255]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[13]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[426]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[427]

Drug(s) Affected By Fibroblast growth factor-binding protein 1 (FGFBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[135]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[26]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[422]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[110]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[428]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[414]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[27]

Drug(s) Affected By Latent-transforming growth factor beta-binding protein 2 (LTBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[375]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[26]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[33]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[42]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[373]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[373]

Drug(s) Affected By Transcription elongation factor A protein-like 1 (TCEAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[429]
Bortezomib	DMNO38U	Leukemia		Approved	[430]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[109]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[431]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[33]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[27]

Drug(s) Affected By Transcriptional enhancer factor TEF-3 (TEAD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[397]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[256]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[16]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]

Drug(s) Affected By 2'-5'-oligoadenylate synthase-like protein (OASL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[284]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[45]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[24]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[284]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 14 (PTPN14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[371]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[375]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[432]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[33]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[42]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[433]

Drug(s) Affected By Cystatin-M (CST6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[21]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[434]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[435]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[42]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[43]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[436]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[437]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[139]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[438]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[439]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[440]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[441]

Drug(s) Affected By Dual specificity protein phosphatase 5 (DUSP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[442]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[443]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[58]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[16]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]

Drug(s) Affected By Mesoderm-specific transcript homolog protein (MEST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[444]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[445]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[33]

Drug(s) Affected By Collagen alpha-1(XIII) chain (COL13A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[446]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[379]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[404]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[33]

Drug(s) Affected By Rho guanine nucleotide exchange factor 16 (ARHGEF16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[109]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[27]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[50]

Drug(s) Affected By Neuroepithelial cell-transforming gene 1 protein (NET1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Indomethacin	DMSC4A7	Bursitis		Approved	[447]

Drug(s) Affected By SEC14-like protein 1 (SEC14L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[315]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[422]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[33]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[448]

Drug(s) Affected By Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (LPGAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[54]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[149]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[371]

Drug(s) Affected By Serine protease HTRA1 (HTRA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[449]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Tirbanibulin	DMJNV4O	Actinic keratosis	EK90.0	Approved	[449]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[20]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[449]

Drug(s) Affected By Kallikrein-6 (KLK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[58]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[3]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[379]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[379]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[450]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[411]

Drug(s) Affected By Lysosomal-trafficking regulator (LYST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[93]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[310]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[137]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[199]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[33]

Drug(s) Affected By ATP-sensitive inward rectifier potassium channel 15 (KCNJ15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[283]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[58]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[451]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[29]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[452]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[27]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[453]

Drug(s) Affected By Cell division control protein 6 homolog (CDC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[82]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[454]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[46]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[207]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[455]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]

Drug(s) Affected By Equilibrative nucleoside transporter 1 (SLC29A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[456]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[457]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[458]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[459]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[460]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]

Drug(s) Affected By SNF-related serine/threonine-protein kinase (SNRK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[366]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[461]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[50]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[462]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[463]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[464]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[465]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[116]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[466]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[467]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[246]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[468]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[220]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[401]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[469]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[470]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[471]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[219]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[222]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[472]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[473]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[474]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[475]

Drug(s) Affected By SAM pointed domain-containing Ets transcription factor (SPDEF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[199]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[35]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[476]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[414]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[27]
Oxalic Acid	DMLN2GQ	Discovery agent	N.A.	Investigative	[477]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[282]

Drug(s) Affected By Parathyroid hormone (PTH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[478]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[479]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[480]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[481]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[26]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[482]
Phosphate	DMUXQG7	Constipation	DD91.1	Approved	[483]
Paricalcitol	DMYBV3G	Hyperparathyroidism	5A51	Approved	[484]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[130]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[130]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[485]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[486]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[487]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[467]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[246]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[488]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[265]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[489]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[490]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[340]

Drug(s) Affected By Cathepsin B (CTSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[436]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[116]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[491]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[492]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[493]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[494]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[495]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[463]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[496]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[497]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[498]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[130]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[465]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[499]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[500]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[501]

Drug(s) Affected By Clusterin (CLU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[272]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[272]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[256]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[502]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[29]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[272]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[503]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[264]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[220]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[265]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[504]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[505]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[506]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[507]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[82]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[217]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[503]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[508]
Selenium	DM25CGV	N. A.	N. A.	Approved	[218]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[220]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[509]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[510]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[511]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[340]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[512]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[419]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[211]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[469]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[467]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[219]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[513]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[220]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[454]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[486]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[514]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[513]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[515]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[516]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[517]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[518]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[504]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[519]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[520]

Drug(s) Affected By Cathelicidin antimicrobial peptide (CAMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[521]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[522]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[523]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[40]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[523]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[524]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Vitamin D3 receptor (VDR)	TTK59TV	VDR_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)	OTG2T749	CP24A_HUMAN	Gene/Protein Processing	[3]
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)	OT3K7HY5	DHB2_HUMAN	Gene/Protein Processing	[3]
2'-5'-oligoadenylate synthase-like protein (OASL)	OTZ05YRP	OASL_HUMAN	Gene/Protein Processing	[3]
A-kinase anchor protein 13 (AKAP13)	OTOZAR14	AKP13_HUMAN	Gene/Protein Processing	[3]
Actin-binding LIM protein 1 (ABLIM1)	OTHXEK3E	ABLM1_HUMAN	Gene/Protein Processing	[3]
Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (LPGAT1)	OTN4HEJ4	LGAT1_HUMAN	Gene/Protein Processing	[3]
Adenosine receptor A2b (ADORA2B)	OTCDYBBP	AA2BR_HUMAN	Gene/Protein Processing	[3]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[3]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Gene/Protein Processing	[3]
Amphiregulin (AREG)	OTJFOR67	AREG_HUMAN	Gene/Protein Processing	[3]

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