Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGEMB7)

Drug Name
Hydrocortisone Drug Info
Synonyms
Acticort; Alacort; Algicirtis; Alphaderm; Amberin; Anflam; Anucort; Aquacort; Cetacort; Chronocort; Cleiton; Cobadex; Colocort; Corhydron; Cortanal; Cortef; Cortenema; Cortesal; Corticreme; Cortifair; Cortifan; Cortiment; Cortisol; Cortisolonum; Cortisporin; Cortispray; Cortolotion; Cortonema; Cortoxide; Cortril; Cremesone; Cutisol; Delacort; Dermacort; Dermaspray; Dermil; Dermocortal; Dermolate; Dihydrocostisone; Dioderm; Drotic; DuoCort; Efcorbin; Efcortelan; Efcortelin; Eldecort; Eldercort; Epicort; Epicortisol; Evacort; Ficortril; Fiocortril; Flexicort; Genacort; Glycort; Hidalone; Hycort; Hycortol; Hycortole; Hydracort; Hydrasson; Hydrocortal; Hydrocorticosterone; Hydrocortisyl; Hydrocortone; Hydroskin; Hydroxycortisone; Hytisone; Hytone; Idrocortisone; Kyypakkaus; Lactisona; Lubricort; Maintasone; Medicort; Meusicort; Mildison; Milliderm; Nutracort; Optef; Otocort; Penecort; Permicort; Prepcort; Proctocort; Protocort; Rectoid; Sanatison; Schericur; Sigmacort; Signef; Stiefcorcil; Synacort; Tarcortin; Texacort; Timocort; Traumaide; Uniderm; Vytone; Zenoxone; ACETASOL HC; Aeroseb HC; AnusolHC; Aquanil HC; Barseb HC; CaldeCORT Spray; Clear aid; Component of Lubricort; Component of Otalgine; Cortisol alcohol; Cortisporin Otico; Ef corlin; Epiderm H; Esiderm H; Foille Insetti; HYDROCORTISONE AND ACETIC ACID; HYDROCORTISONE IN ABSORBASE; Heb Cort; Hydrocortisone alcohol; Hydrocortisone base; Hydrocortisone free alcohol; Hydrocortisone solution; Hytone lotion; Idrocortisone [DCIT]; Komed HC; Lacticare HC; Nogenic HC; ORLEX HC; Pediotic Suspension; Polcort H; Preparation H Hydrocortisone Cream; Prevex HC; Proctozone HC; Remederm HC; Scalpicin Capilar; Scheroson F; Systral Hydrocort; Transderma H; VoSol HC; H 4001; Texacort lotion 25; [3H]cortisol; ACETIC ACID W/ HYDROCORTISONE; Acticort (TN); Aeroseb-HC; Ala-Cort; Ala-Scalp; Anti-inflammatory hormone; Anucort-HC; Anusol HC (TN); Balneol-hc; Basan-Corti; Beta-hc; COR-OTICIN; Colocort (TN); Cort-Dome; Cortef (TN); Cortisol, Hydrocortisone; Cremicort-H; Cyclodextrin-encapsulated hydrocortisone; Derm-Aid; Dome-cort; Domolene-HC; Genacort (lotion); Gyno-Cortisone; H-Cort; HC #1; HC #4; HC (HYDROCORTISONE); Heb-Cort; Hi-cor; Hidro-Colisona; Hidrocortisona [INN-Spanish]; Hydro-Adreson; Hydro-Colisona; Hydro-RX; Hydrocortisone-Water Soluble; Hydrocortisonum [INN-Latin]; Hytone (TN); Incortin-H; Incortin-hydrogen; Kendall's compound F; Lacticare-HC; Neo-Cortef; Neosporin-H Ear; Nystaform-HC; Otosone-F; Rectasol-HC; Reichstein's substance M; Scalp-Cort; Stie-cort; Component of Neo-Cort-Dome; Hydrocortisone [INN:BAN:JAN]; Hydrocortisone (JP15/USP/INN); 11-beta-Hydrocortisone; 11-beta-Hydroxycortisone; 11beta,17,21-Trihydroxyprogesterone; 11beta-Hydrocortisone; 11beta-Hydroxycortisone; 17-Hydroxycorticosterone; 17alpha-Hydroxycorticosterone
Indication
Disease Entry ICD 11 Status REF
Inflammation 1A00-CA43.1 Approved [1] , [2]
Congenital adrenal hyperplasia 5A71.01 Phase 2 [3]
Therapeutic Class
Antiinflammatory Agents
Cross-matching ID
PubChem CID
5754
ChEBI ID
CHEBI:17650
CAS Number
CAS 50-23-7
TTD Drug ID
DMGEMB7
VARIDT Drug ID
DR00230
INTEDE Drug ID
DR0819
ACDINA Drug ID
D00314

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Solid tumour/cancer 2A00-2F9Z Approved [10]
Progesterone DMUY35B Premature labour JB00 Approved [11]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [12]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [13]
Acetaminophen DMUIE76 Pain MG30-MG3Z Approved [14]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [15]
Etoposide DMNH3PG Solid tumour/cancer 2A00-2F9Z Approved [16]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [17]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [11]
Verapamil DMA7PEW Hypertension BA00-BA04 Approved [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Solid tumour/cancer 2A00-2F9Z Approved [19]
Progesterone DMUY35B Premature labour JB00 Approved [20]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [21]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [22]
Acetaminophen DMUIE76 Pain MG30-MG3Z Approved [23]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [24]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [25]
Etoposide DMNH3PG Solid tumour/cancer 2A00-2F9Z Approved [26]
Verapamil DMA7PEW Hypertension BA00-BA04 Approved [27]
Sorafenib DMS8IFC Hepatocellular carcinoma 2C12.02 Approved [22]
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Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Premature labour JB00 Approved [28]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [22]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [22]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [22]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [29]
Verapamil DMA7PEW Hypertension BA00-BA04 Approved [30]
Sorafenib DMS8IFC Hepatocellular carcinoma 2C12.02 Approved [22]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [22]
Irinotecan DMP6SC2 Colorectal cancer 2B91.Z Approved [22]
Metronidazole DMTIVEN Amoebiasis 1A36 Approved [31]
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Drug(s) Metabolized By Steroid 11-beta-hydroxylase (CYP11B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [32]
Deoxycorticosterone DMW6YLS Discovery agent N.A. Investigative [29]
Drug(s) Metabolized By Aldosterone synthase (CYP11B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [33]
Deoxycorticosterone DMW6YLS Discovery agent N.A. Investigative [34]
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Bacterial infection 1A00-1C4Z Approved [35]
Doxorubicin DMVP5YE Solid tumour/cancer 2A00-2F9Z Approved [36]
Methotrexate DM2TEOL leukaemia 2A60-2B33 Approved [37]
Folic acid DMEMBJC Folate-deficiency anemia 3A02.Y Approved [38]
Fluorouracil DMUM7HZ Solid tumour/cancer 2A00-2F9Z Approved [37]
Cisplatin DMRHGI9 Solid tumour/cancer 2A00-2F9Z Approved [37]
Progesterone DMUY35B Premature labour JB00 Approved [39]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [37]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [40]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [41]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Glucocorticoid receptor (NR3C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Rheumatoid arthritis FA20 Approved [42]
Prednisolone DMQ8FR2 Solid tumour/cancer 2A00-2F9Z Approved [43]
Fluticasone DMGCSVF Allergic rhinitis CA08.0 Approved [44]
Betamethasone valerate DMMIAXO Dermatological disease DA24.Y Approved [4]
Methylprednisolone DM4BDON Solid tumour/cancer 2A00-2F9Z Approved [4]
Deflazacort DMV0RNS Duchenne dystrophy 8C70 Approved [4]
Prednisone DM2HG4X Inflammation 1A00-CA43.1 Approved [45]
Budesonide DMJIBAW Asthma CA23 Approved [46]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [47]
Fluocinolone acetonide DMG2KI4 Inflammation 1A00-CA43.1 Approved [4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glucocorticoid receptor (NR3C1) TTYRL6O GCR_HUMAN Modulator [4]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [6]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [7]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Substrate [8]
Steroid 11-beta-hydroxylase (CYP11B1) DEPE0RD C11B1_HUMAN Substrate [9]
Aldosterone synthase (CYP11B2) DE6TYUK C11B2_HUMAN Substrate [9]

References

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22 Drug Interactions Flockhart Table
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