Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7V2LG)

• Drug Name: Chrysin Drug Info
• Synonyms: chrysin; 480-40-0; 5,7-Dihydroxyflavone; Chrysine; 5,7-Dihydroxy-2-phenyl-4H-chromen-4-one; Crysin; 5,7-dihydroxy-2-phenylchromen-4-one; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-phenyl-; UNII-3CN01F5ZJ5; NSC-407436; FLAVONE, 5,7-DIHYDROXY-; EINECS 207-549-7; NSC407436; 5,7-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one; CHEMBL117; NSC 407436; 5,7-Dihydroxy-2-phenyl-chromen-4-one; BRN 0233276; 3CN01F5ZJ5; CHEBI:75095; RTIXKCRFFJGDFG-UHFFFAOYSA-N; 5,7-Dihydroxy-2-phenyl-4H-benzo(b)pyran-4-one; MFCD00006834; Chrysin, 99+%; CAS-480-40-0

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5281607
  ChEBI ID: CHEBI:75095
  CAS Number: CAS 480-40-0
  TTD Drug ID: DM7V2LG
  VARIDT Drug ID: DR01258
  INTEDE Drug ID: DR1939

Molecule-Related Drug Atlas

Drug(s) Targeting Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Anastrozole	DMNP60F	Breast cancer	2C60-2C65	Approved	[17]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[18]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[18]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[19]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[20]
Testolactone	DMVY4GN	Breast cancer	2C60-2C65	Approved	[21]
LIAROZOLE	DM4OYXE	Dermatological disease	DA24.Y	Phase 2/3	[3]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[22]
BGS-649	DMO4MNQ	Endometriosis	GA10	Phase 2	[23]
NARINGENIN	DMHAZLM	N. A.	N. A.	Phase 1	[3]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[83]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[85]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[85]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[88]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[90]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[85]

Drug(s) Targeting Aldose reductase (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epalrestat	DM5OGK0	Diabetic neuropathy	8C0Z	Approved	[24]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[25]
Fidarestat	DMZL1I8	Diabetic complication	5A2Y	Phase 3	[26]
Ranirestat	DMD5QRS	Diabetic neuropathy	8C0Z	Phase 3	[27]
CONTIGOSIDE B	DMX9V8K	Thrombosis	DB61-GB90	Phase 2/3	[28]
BNV-222	DMYFQJL	Diabetic neuropathy	8C0Z	Phase 2/3	[27]
BNV-222	DMYFQJL	Diabetic neuropathy	8C0Z	Phase 2/3	[29]
LIDORESTAT	DMA0RI9	Diabetic complication	5A2Y	Phase 2	[30]
QR-333	DMKVIWM	Diabetic neuropathy	8C0Z	Phase 2	[31]
ADMVA	DM819CO	Diabetic complication	5A2Y	Phase 2	[27]

Drug(s) Targeting Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[5]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[5]
MORIN	DM2OGZ5	Discovery agent	N.A.	Investigative	[5]
3,7,3',4'-TETRAHYDROXYFLAVONE	DMES906	Discovery agent	N.A.	Investigative	[5]
(-)-CATECHINGALLATE	DMZOGSK	Discovery agent	N.A.	Investigative	[5]
2-Hexadecynoic acid	DMTFIPZ	Discovery agent	N.A.	Investigative	[32]
GALLOCATECHIN GALLATE	DMX2084	Discovery agent	N.A.	Investigative	[5]
ISORHAMNETIN	DMQ4Z6E	Discovery agent	N.A.	Investigative	[5]
NADPH	DM75Q34	Discovery agent	N.A.	Investigative	[33]

Drug(s) Targeting Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Apremilast	DMTWS9E	Psoriasis vulgaris	EA90	Approved	[34]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[35]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[36]
Ribociclib Succinate	DM9CIUW	Breast cancer	2C60-2C65	Approved	[37]
Trilaciclib	DMP5A4T	Small-cell lung cancer	2C25.Y	Approved	[38]
LEE011	DMMX75K	Breast cancer	2C60-2C65	Phase 3	[39]
G1T38	DMQO2IT	Breast cancer	2C60-2C65	Phase 2	[40]
GLR2007	DM7DWLY	Glioblastoma of brain	2A00.00	Phase 1/2	[41]
FCN-437	DMQ8VUW	Breast cancer	2C60-2C65	Phase 1/2	[42]
NUV-422	DMQJQNT	Malignant glioma	2A00.0	Phase 1/2	[43]

Drug(s) Targeting Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PINOCEMBRIN	DM96VWD	N. A.	N. A.	Phase 2	[1]
NARINGENIN	DMHAZLM	N. A.	N. A.	Phase 1	[1]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[1]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[1]
ISORHAMNETIN	DMQ4Z6E	Discovery agent	N.A.	Investigative	[1]
ACACETIN	DMQOB0X	Discovery agent	N.A.	Investigative	[1]
TRISMETHOXYRESVERATROL	DM6USPC	Discovery agent	N.A.	Investigative	[44]
Galangin	DM5TQ2O	Discovery agent	N.A.	Investigative	[1]
CHRYSOERIOL	DM96ECL	Discovery agent	N.A.	Investigative	[1]
DIOSMETIN	DM4KXIM	Discovery agent	N.A.	Investigative	[1]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[159]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[198]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[199]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[200]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[201]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[202]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[203]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[104]

Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[46]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[47]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[48]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[50]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[51]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[50]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[52]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[53]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[54]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[55]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[56]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[57]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[60]
Metronidazole	DMTIVEN	Abscess		Approved	[61]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[62]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[63]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A9 (UGT1A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[65]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[68]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[67]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[67]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]
Nateglinide	DMLK2QH	Diabetic complication	5A2Y	Approved	[67]
Haloperidol	DM96SE0	Delirium		Approved	[67]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A8 (UGT1A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[70]
Empagliflozin	DMRF9YK	Type-1 diabetes	5A10	Approved	[71]
Darolutamide	DMV7YFT	Prostate cancer	2C82.0	Approved	[72]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[7]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[73]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[7]
phloretin	DMYA50U	Discovery agent	N.A.	Investigative	[7]
Anthraflavic acid	DMN1YFU	N. A.	N. A.	Investigative	[7]
Cis-4-hydroxytamoxifen	DMRFTB5	N. A.	N. A.	Investigative	[73]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A7 (UGT1A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[70]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[7]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[7]
phloretin	DMYA50U	Discovery agent	N.A.	Investigative	[7]
Anthraflavic acid	DMN1YFU	N. A.	N. A.	Investigative	[7]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[74]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[74]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[75]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[76]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[77]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[78]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[81]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[82]

Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[94]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[98]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[99]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[100]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[101]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[102]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[104]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[105]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[106]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[109]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[107]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[110]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[111]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[112]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[114]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[115]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[116]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[118]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[118]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[118]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[119]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[120]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[121]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[122]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[123]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[124]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[76]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[125]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[126]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[126]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[128]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[126]
Fructose	DM43AN2	Vomiting	MD90	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[126]

Drug(s) Affected By Lathosterol oxidase (SC5D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[131]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[134]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[135]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Haloperidol	DM96SE0	Delirium		Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[138]

Drug(s) Affected By Acyl-CoA 6-desaturase (FADS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[131]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[140]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[138]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[141]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[142]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[143]
Bortezomib	DMNO38U	Leukemia		Approved	[144]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[106]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[146]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[107]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[147]
Selenium	DM25CGV	N. A.	N. A.	Approved	[148]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[149]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[150]

Drug(s) Affected By HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[151]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[153]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[154]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[155]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[142]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[156]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[157]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[158]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[159]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[160]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[161]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[162]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[163]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[164]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[165]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[166]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[167]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[168]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[169]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[104]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[171]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[106]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[172]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[147]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[173]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]

Drug(s) Affected By Interleukin-1 receptor type 1 (IL1R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[177]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[177]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[180]

Drug(s) Affected By Interleukin-15 (IL15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[182]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[183]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[184]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[185]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[186]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[187]
Bortezomib	DMNO38U	Leukemia		Approved	[144]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[188]

Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[191]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[192]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[193]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[194]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[137]

Drug(s) Affected By ATP-binding cassette sub-family C member 5 (ABCC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[204]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[205]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[206]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[207]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[209]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[210]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[183]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[211]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[138]

Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[213]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[214]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[215]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[216]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[217]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[218]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[219]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[104]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[220]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[106]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Selenium	DM25CGV	N. A.	N. A.	Approved	[222]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[223]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[224]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[94]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[220]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[226]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Selenium	DM25CGV	N. A.	N. A.	Approved	[151]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[227]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[228]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[229]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[230]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[231]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[232]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[233]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[234]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[235]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[236]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[237]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[238]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[239]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[240]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[241]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[242]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[243]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[244]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[246]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[247]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[248]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[249]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[137]

Drug(s) Affected By Serine/threonine-protein kinase Sgk1 (SGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[250]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[251]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[252]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[253]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[182]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[254]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[250]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[255]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[256]

Drug(s) Affected By Tumor protein p73 (TP73)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[257]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[258]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[259]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[260]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[262]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[263]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[258]

Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[265]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[266]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[194]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[194]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[267]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[138]

Drug(s) Affected By Prostate stem cell antigen (PSCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[268]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[180]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[269]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[270]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[271]
ACYLINE	DM9GRTK	Prostate cancer	2C82.0	Phase 2	[272]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[273]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[226]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[265]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[266]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[256]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[194]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[274]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[275]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[277]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[267]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[278]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[279]

Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[280]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[281]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[282]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[283]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[182]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[280]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[265]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[267]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[285]

Drug(s) Affected By Erythropoietin (EPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[286]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[288]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[137]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[289]
Fenoterol	DMIP3ZV	Asthma	CA23	Approved	[290]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[291]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[292]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[293]

Drug(s) Affected By Fibronectin (FN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[294]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[175]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[295]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[296]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[297]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[134]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[298]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[299]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[300]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[301]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[302]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[303]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[94]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[304]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[305]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[306]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[308]

Drug(s) Affected By Sex hormone-binding globulin (SHBG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[309]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]
Fructose	DM43AN2	Vomiting	MD90	Approved	[310]
Oxcarbazepine	DM5PU6O	Epilepsy	8A60-8A68	Approved	[311]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[312]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[313]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[179]
Dienestrol	DMBSXI0	Atrophic vaginitis	GA30.2	Approved	[312]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[312]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[312]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[314]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[315]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[316]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[317]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[318]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[319]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[320]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[321]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[322]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[323]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[324]
Fructose	DM43AN2	Vomiting	MD90	Approved	[76]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[325]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[105]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[226]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[327]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[328]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[329]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[330]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[331]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[332]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[333]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[334]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[335]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[336]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[337]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[338]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[336]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[301]
Selenium	DM25CGV	N. A.	N. A.	Approved	[339]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[340]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[341]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[342]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[343]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[344]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[345]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[346]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[348]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[349]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[350]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[350]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[351]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[352]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[353]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[354]

Drug(s) Affected By Stromelysin-2 (MMP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[137]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[356]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[168]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[356]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[256]
Haloperidol	DM96SE0	Delirium		Approved	[357]

Drug(s) Affected By Fructose-1,6-bisphosphatase 1 (FBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[182]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[358]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[359]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[360]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[361]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[362]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[363]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[364]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[365]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[366]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[367]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[368]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[367]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[369]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[370]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[371]

Drug(s) Affected By Myb-related protein A (MYBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[250]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[372]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[250]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[373]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[374]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[252]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[375]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[376]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[377]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[378]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[379]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[182]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[380]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[265]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[381]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Selenium	DM25CGV	N. A.	N. A.	Approved	[382]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[258]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[368]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[383]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[384]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]

Drug(s) Affected By Cadherin-2 (CDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[386]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[387]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[265]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[388]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[389]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[390]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[391]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[392]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[357]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[393]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[392]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[180]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[141]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[394]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[395]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[396]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[397]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[76]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[398]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[106]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[399]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[400]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[401]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[402]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[404]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[405]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[406]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[407]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[408]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[409]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[410]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[411]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[412]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[413]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[404]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[414]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[415]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[416]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[76]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[406]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[407]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[417]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[418]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[320]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[419]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[420]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[421]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[422]
Selenium	DM25CGV	N. A.	N. A.	Approved	[151]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[423]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[424]

Drug(s) Affected By 14-3-3 protein sigma (SFN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[425]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[426]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[280]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[132]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[280]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[265]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[427]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[428]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[429]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[430]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[431]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[432]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[433]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[434]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[182]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[247]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[435]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[436]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[437]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[438]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[439]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[258]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[440]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[368]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[253]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[441]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[442]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[443]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[317]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[444]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[445]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[446]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[447]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[448]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[398]

Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor C (CDKN2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[283]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[449]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[450]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[451]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[194]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[194]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[267]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[137]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[452]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[375]
Selenium	DM25CGV	N. A.	N. A.	Approved	[151]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[453]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[454]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[455]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[449]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[456]

Drug(s) Affected By 6-phosphogluconate dehydrogenase, decarboxylating (PGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[137]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[180]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[141]
Methylene blue	DMJAPE7	Acquired methemoglobinemia	3A93	Approved	[457]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[217]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[458]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[459]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[460]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[461]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[462]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[366]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[463]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[464]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[465]

Drug(s) Affected By Laminin subunit beta-2 (LAMB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[466]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[180]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[467]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[156]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[468]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[269]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[130]

Drug(s) Affected By Transforming protein RhoA (RHOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[469]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[94]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[470]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[471]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[356]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[356]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[472]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[473]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[474]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[475]

Drug(s) Affected By Growth factor receptor-bound protein 2 (GRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[476]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[183]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[477]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[392]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[478]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[138]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[141]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[262]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[419]
Selenium	DM25CGV	N. A.	N. A.	Approved	[151]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[479]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[480]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[402]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[481]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[482]

Drug(s) Affected By Focal adhesion kinase 1 (PTK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[408]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[483]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[471]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[484]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[485]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[486]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[487]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[138]

Drug(s) Affected By Son of sevenless homolog 1 (SOS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[327]
Selenium	DM25CGV	N. A.	N. A.	Approved	[151]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[488]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[256]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[392]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[267]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[489]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[490]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[180]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[491]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[492]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[493]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[494]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[495]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[366]
Selenium	DM25CGV	N. A.	N. A.	Approved	[151]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[464]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[496]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[497]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[498]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[498]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[499]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[500]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[501]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[502]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[131]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[503]

Drug(s) Affected By Protein GREB1 (GREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[252]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[504]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[138]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[252]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[505]
Mestranol	DMG3F94	Contraception	QA21	Approved	[252]

Drug(s) Affected By Quinone oxidoreductase PIG3 (TP53I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[366]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[506]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[507]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[508]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[509]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[509]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[509]

Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[510]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[511]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[512]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[513]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[514]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[515]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[516]
Mestranol	DMG3F94	Contraception	QA21	Approved	[517]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[518]

Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[519]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[520]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[521]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[522]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[204]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[523]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[524]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[525]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[526]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[527]

Drug(s) Affected By Tumor protein 63 (TP63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[528]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[529]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[359]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[530]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[531]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[361]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[532]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[269]

Drug(s) Affected By Serine/threonine-protein kinase TBK1 (TBK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[533]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[534]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[535]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[141]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[361]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[324]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[536]
Flavonoid derivative 1	DMCQP0B	N. A.	N. A.	Patented	[535]

Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[270]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[537]
Minoxidil	DMA2Z4F	Alopecia	ED70	Approved	[538]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[539]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[538]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[540]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[541]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[542]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[543]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[544]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[545]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[76]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[546]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[460]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[406]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[419]

Drug(s) Affected By Cytochrome P450 2A13 (CYP2A13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[547]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[548]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[548]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[202]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[549]
HELENALIN	DMMCI4H	N. A.	N. A.	Terminated	[550]
Acenaphthenol	DMT3QYZ	N. A.	N. A.	Investigative	[551]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[552]
BRN-3548355	DM4KXT0	N. A.	N. A.	Investigative	[552]
9-phenanthrol	DMJFBQ1	Discovery agent	N.A.	Investigative	[553]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aldose reductase (AKR1B1)	TTFBNVI	ALDR_HUMAN	Inhibitor	[2]
Aromatase (CYP19A1)	TTSZLWK	CP19A_HUMAN	Inhibitor	[3]
Cyclin-dependent kinase 6 (CDK6)	TTO0FDJ	CDK6_HUMAN	Inhibitor	[4]
Cytochrome P450 1B1 (CYP1B1)	TTI84H7	CP1B1_HUMAN	Inhibitor	[1]
Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG)	TTBE4IR	Q965D6_PLAFA	Inhibitor	[5]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[6]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Substrate	[7]
UDP-glucuronosyltransferase 1A9 (UGT1A9)	DE85D2P	UD19_HUMAN	Substrate	[7]
UDP-glucuronosyltransferase 1A8 (UGT1A8)	DE2GB8N	UD18_HUMAN	Substrate	[7]
UDP-glucuronosyltransferase 1A7 (UGT1A7)	DEZO4N3	UD17_HUMAN	Substrate	[7]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)	OTSBQR6D	PLCG1_HUMAN	Protein Interaction/Cellular Processes	[8]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Gene/Protein Processing	[9]
6-phosphogluconate dehydrogenase, decarboxylating (PGD)	OTVG296F	6PGD_HUMAN	Gene/Protein Processing	[10]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[11]
Acyl-CoA 6-desaturase (FADS2)	OTUX531P	FADS2_HUMAN	Gene/Protein Processing	[12]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Gene/Protein Processing	[13]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Drug Response	[8]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Gene/Protein Processing	[14]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Gene/Protein Processing	[15]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Gene/Protein Processing	[16]

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