Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMF28YC)

• Drug Name: Atorvastatin Drug Info
• Synonyms: Atogal; Atorlip; Atorpic; Atorvastatina; Atorvastatine; Atorvastatinium; Atrovastin; Cardyl; Faboxim; Lipotropic; Lipovastatinklonal; Liprimar; Lowden; Sincol; Sortis; Sotis; Torvacard; Torvast; Totalip; Tozalip; Tulip; Vastina; Xanator; Xarator; Xavator; Zurinel; Atorvastatin (INN); Atorvastatin [INN:BAN]; Lipitor (TN); Lipitor(TM); Sortis (TN); (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid; (3R,5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid; (R-(R*,R*))-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1H-pyrrole-1-heptanoic acid; (betaR,deltaR)-2-(p-Fluorophenyl)-beta,delta-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-1-heptanoic acid; 7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]-3,5-DIHYDROXY-HEPTANOIC ACID

Indication

Disease Entry	ICD 11	Status	REF
Acute coronary syndrome	BA41	Approved	[1]
Angina pectoris	BA40	Approved	[1]
Arteriosclerosis	BD40	Approved	[1]
Cardiovascular disease	BA00-BE2Z	Approved	[2]
Coronary atherosclerosis		Approved	[1]
Hypercholesterolaemia	5C80.0	Approved	[1]
Hyperlipidemia	5C80.Z	Approved	[3]
Hyperlipidemia, familial combined, LPL related		Approved	[1]
Hypertriglyceridemia	5C80.1	Approved	[1]
Inflammation	1A00-CA43.1	Approved	[1]
Non-insulin dependent diabetes	5A11	Approved	[1]
Psoriasis	EA90	Approved	[1]
Type-1/2 diabetes	5A10-5A11	Approved	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[4]
Stroke	8B20	Investigative	[1]
Venous thromboembolism	BD72	Investigative	[1]

• Therapeutic Class: Anticholesteremic Agents
• Cross-matching ID:
  PubChem CID: 60823
  ChEBI ID: CHEBI:39548
  CAS Number: CAS 134523-00-5
  TTD Drug ID: DMF28YC
  VARIDT Drug ID: DR00030
  INTEDE Drug ID: DR0155
  ACDINA Drug ID: D00050

Molecule-Related Drug Atlas

Drug(s) Targeting HMG-CoA reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[30]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[31]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[32]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[33]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[5]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[34]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[5]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[35]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[34]
TOCOTRIENOL	DM1UE67	Hyperlipidaemia	5C80	Approved	[36]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[37]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[40]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[39]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[41]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[43]

Drug(s) Transported By Organic anion transporting polypeptide 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[45]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[46]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[47]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[46]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[48]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[49]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[12]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[48]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[50]

Drug(s) Transported By Organic anion transporting polypeptide 1A2 (SLCO1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[52]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[53]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[54]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[55]
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[56]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[57]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[58]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[59]
Labetalol	DMK8U72	Hypertension	BA00-BA04	Approved	[60]

Drug(s) Transported By Organic anion transporting polypeptide 1B3 (SLCO1B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[61]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[46]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[62]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[63]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[46]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[64]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[49]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[65]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[12]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[66]

Drug(s) Transported By Organic anion transporting polypeptide 2B1 (SLCO2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[67]
L-Glutamic Acid	DM4PUDW	Schizophrenia	6A20	Approved	[68]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[69]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[47]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[70]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[71]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[72]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[73]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[50]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[74]

Drug(s) Transported By Monocarboxylate transporter 1 (SLC16A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[75]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[8]
Gamma Hydroxybutyric Acid	DMGBKVD	Narcolepsy	7A20	Approved	[76]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[77]
Gabapentin enacarbil	DMJY2TM	Postherpetic neuralgia	1E91.5	Phase 2	[78]
Pyroglutamic Acid	DMROZUA	Discovery agent	N.A.	Investigative	[79]
Butanoic Acid	DMTAJP7	Discovery agent	N.A.	Investigative	[78]
Hydroxyacetic Acid	DMQFBH6	Discovery agent	N.A.	Investigative	[80]
biotin	DMKMCE1	Discovery agent	N.A.	Investigative	[81]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[82]

Drug(s) Transported By Monocarboxylate transporter 2 (SLC16A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[7]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[7]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[7]
Propicillin	DMWDHUZ	Bacterial infection	1A00-1C4Z	Approved	[7]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[84]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[86]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[87]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[89]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[90]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[91]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[92]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[86]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[14]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[137]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[139]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[140]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[141]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[141]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[142]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[143]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[144]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[145]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[93]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[95]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[96]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[99]
Metronidazole	DMTIVEN	Abscess		Approved	[100]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[101]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[102]

Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[103]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[104]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[107]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[108]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[109]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[110]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[111]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[106]

Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[112]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[106]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[106]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[106]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[113]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[114]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[106]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[106]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[106]
Metronidazole	DMTIVEN	Abscess		Approved	[115]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[116]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[17]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[113]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[117]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[118]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[119]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[17]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[120]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[121]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A3 (UGT1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[14]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[123]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[124]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[125]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[126]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[127]
Losartan	DM72JXH	Diabetic kidney disease	GB61.Z	Approved	[14]
Naproxen	DMZ5RGV	Bursitis		Approved	[128]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[129]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[129]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[129]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[130]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[131]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[132]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[134]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]

Drug(s) Affected By Apolipoprotein E (APOE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[146]
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[149]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[156]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[157]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[129]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[158]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[160]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[149]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]

Drug(s) Affected By Kinesin-like protein KIF6 (KIF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[164]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[165]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[166]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[167]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[168]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[168]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[168]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[166]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[169]

Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[170]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[171]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[172]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[173]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[176]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[177]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[178]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[179]

Drug(s) Affected By Serum paraoxonase/arylesterase 1 (PON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[180]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[182]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[183]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[184]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[185]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[186]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[187]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[188]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[180]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[189]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[190]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[191]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[192]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[193]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[194]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[195]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[196]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[197]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[198]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[200]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[201]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[202]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[204]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[205]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[206]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[208]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[160]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[149]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[212]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[213]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]

Drug(s) Affected By Sterol 26-hydroxylase, mitochondrial (CYP27A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[215]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[208]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[149]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[217]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[218]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]

Drug(s) Affected By Angiopoietin-2 (ANGPT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[223]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[186]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[224]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[225]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[226]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[227]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]

Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[228]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[229]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[230]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[228]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[186]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[231]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[232]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]

Drug(s) Affected By Thrombospondin-1 (THBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[233]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[131]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[235]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[236]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[216]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[237]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[238]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[239]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[240]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[242]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[243]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[244]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[245]
Selenium	DM25CGV	N. A.	N. A.	Approved	[246]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[247]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[248]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[249]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[250]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[251]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[129]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[252]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[229]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[253]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[254]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[255]
Fructose	DM43AN2	Vomiting	MD90	Approved	[256]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[257]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[258]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[259]
Haloperidol	DM96SE0	Delirium		Approved	[129]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[260]
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[262]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[263]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[265]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[266]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[266]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[267]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[265]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[266]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[268]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[265]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[269]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[265]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[270]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[270]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[271]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[272]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[273]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[270]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[270]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[270]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[199]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[274]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[275]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[276]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[229]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[277]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[278]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[279]

Drug(s) Affected By Hexokinase-4 (GCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[280]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[281]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[283]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[284]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[285]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[286]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[287]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[288]

Drug(s) Affected By Toll-like receptor 4 (TLR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[289]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[290]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[223]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[239]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[291]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[292]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[293]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[294]

Drug(s) Affected By Toll-like receptor 2 (TLR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[237]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[289]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[290]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[237]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[295]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[296]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[291]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[297]

Drug(s) Affected By Prothrombin (F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[298]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[299]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[300]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[301]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[302]
Phytonadione	DM8HDOL	Bleeding disorder	GA20-GA21	Approved	[303]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[304]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[305]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[306]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[307]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[308]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[309]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[310]
Selenium	DM25CGV	N. A.	N. A.	Approved	[311]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[312]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[313]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[314]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[315]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[158]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[315]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[316]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[20]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[149]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[317]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[318]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[319]

Drug(s) Affected By Insulin (INS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[320]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[321]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[322]
Fructose	DM43AN2	Vomiting	MD90	Approved	[323]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[324]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[325]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[326]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[327]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[328]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[329]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[330]
Fructose	DM43AN2	Vomiting	MD90	Approved	[129]
Ketoprofen	DMRKXPT	Bursitis		Approved	[129]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[331]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[332]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[333]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[334]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[335]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]

Drug(s) Affected By Interleukin-2 receptor subunit alpha (IL2RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[229]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[336]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[337]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[338]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[339]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[340]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[341]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[284]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[342]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[129]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[343]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[344]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[345]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[346]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[347]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[348]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[349]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[350]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[351]

Drug(s) Affected By C-reactive protein (CRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[129]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[352]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[353]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[354]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[149]
Acalabrutinib	DM7GCVW	leukaemia	2A60-2B33	Approved	[355]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[356]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[357]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[358]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[218]

Drug(s) Affected By Transferrin receptor protein 1 (TFRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[359]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[360]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[289]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[361]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[362]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[363]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[319]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[364]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[365]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[366]

Drug(s) Affected By Osteocalcin (BGLAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[367]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[368]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[346]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[369]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[370]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[371]
Falecalcitrol	DMBI9ZJ	Hyperparathyroidism	5A51	Approved	[372]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[373]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[374]

Drug(s) Affected By Apolipoprotein B-100 (APOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[375]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[376]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[375]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[377]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[149]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[375]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[378]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[375]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[379]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[245]
Selenium	DM25CGV	N. A.	N. A.	Approved	[380]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[237]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[381]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[382]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[383]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[362]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[149]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[384]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[385]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[386]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[387]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[388]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[389]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[390]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[391]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[392]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[393]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[307]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[394]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[395]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[396]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[397]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[363]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[398]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[399]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[400]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[237]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[401]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[402]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[242]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[403]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[244]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[404]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[405]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[237]

Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[406]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[283]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[407]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[249]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[408]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[409]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[410]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[411]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[412]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[413]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[414]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[414]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[129]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[415]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[416]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[417]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[418]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[419]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[420]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[247]

Drug(s) Affected By Integrin beta-1 (ITGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[130]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[345]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[359]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[421]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[422]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[235]
Fructose	DM43AN2	Vomiting	MD90	Approved	[423]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[424]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[425]

Drug(s) Affected By Rho-related GTP-binding protein RhoC (RHOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[299]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[426]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[427]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[428]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[429]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[430]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[431]
Terbinafine	DMI6HUW	Fungal infection	1F29-1F2F	Approved	[432]

Drug(s) Affected By Monocyte differentiation antigen CD14 (CD14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[307]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[149]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[433]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[434]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[435]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[227]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[436]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[402]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[437]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[438]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[439]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[440]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[441]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[440]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[442]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[443]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[444]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[445]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[446]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[447]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[242]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[448]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[244]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[449]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[258]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[450]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[449]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[451]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[452]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[453]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[454]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[129]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[402]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[455]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[456]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[332]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[457]

Drug(s) Affected By Integrin alpha-M (ITGAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[458]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[410]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[459]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[460]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[461]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[294]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[462]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[463]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[464]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[465]

Drug(s) Affected By Coagulation factor V (F5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[224]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[227]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[294]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[431]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[466]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[467]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[468]

Drug(s) Affected By Bone morphogenetic protein 2 (BMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[469]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[470]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[471]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[472]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[186]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[278]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[283]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[294]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[473]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[403]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[233]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[474]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[475]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[476]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[247]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[477]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[478]

Drug(s) Affected By E-selectin (SELE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[479]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[480]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[133]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[481]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[482]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[483]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[484]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[358]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[485]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[486]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[129]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[487]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[488]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[229]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[489]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[490]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[364]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[224]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[491]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[492]

Drug(s) Affected By Integrin alpha-X (ITGAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[493]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[365]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[434]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[494]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[495]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[496]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[496]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[497]
Bryostatin-1	DM1JOXY	Alzheimer disease	8A20	Phase 2	[498]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 5 (CD40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[130]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[289]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[499]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[500]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[501]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[294]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[502]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[503]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[504]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[505]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[506]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[332]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[507]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[508]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[509]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[510]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[511]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[512]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[513]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[505]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[514]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[515]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[516]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[504]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[129]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[130]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[332]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[507]

Drug(s) Affected By Interleukin-12 subunit alpha (IL12A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[517]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[518]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[519]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[520]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[521]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[522]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[523]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[524]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[525]

Drug(s) Affected By CD40 ligand (CD40LG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[499]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[526]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[527]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[528]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[503]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[529]
Eptifibatide	DMQXTJS	Acute cardiac ischemic events	BA40.Z	Approved	[530]
Candesartan	DMRK8OT	Chronic heart failure	BD1Z	Approved	[528]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[531]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[532]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[533]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[359]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[534]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[535]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[158]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[536]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[537]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[441]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[538]

Drug(s) Affected By Nicotinamide N-methyltransferase (NNMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[283]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[539]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[540]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[431]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[541]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[541]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[542]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[543]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[179]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[544]

Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[545]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[546]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[547]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[289]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[547]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[310]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[547]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[278]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[130]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[376]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[224]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[548]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[278]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[549]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[431]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[550]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[551]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[552]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[388]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[553]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[554]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[555]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[556]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[557]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[558]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[559]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[560]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[537]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[561]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[562]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[563]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[564]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[565]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[566]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[567]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[568]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[569]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[570]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[571]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[572]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[573]
Fructose	DM43AN2	Vomiting	MD90	Approved	[423]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[574]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[575]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[576]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[577]
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[159]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[375]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[578]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[236]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[149]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[216]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[579]

Drug(s) Affected By Importin subunit alpha-1 (KPNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[394]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[276]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[580]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[227]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[581]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[232]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[582]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[431]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[542]

Drug(s) Affected By Microsomal triglyceride transfer protein large subunit (MTTP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[375]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[375]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[583]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[375]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[375]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[583]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[584]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[585]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[586]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[402]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[456]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[587]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[588]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[439]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[589]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[590]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[591]

Drug(s) Affected By Transforming protein RhoA (RHOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[592]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[249]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[299]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[593]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[216]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[594]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[595]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]

Drug(s) Affected By Rho-related GTP-binding protein RhoB (RHOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[216]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[186]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[427]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[596]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[232]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[594]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[130]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[597]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[437]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[587]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[598]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[599]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[600]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[601]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[130]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[602]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[602]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[603]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[249]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[604]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[386]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[364]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[605]

Drug(s) Affected By CD83 antigen (CD83)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[606]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[289]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[428]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[607]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[608]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[232]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[429]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[451]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[558]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[402]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[455]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[345]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[587]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[535]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[421]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[609]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[441]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[332]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[345]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[610]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[606]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[611]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[612]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[397]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[345]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[613]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[614]

Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[615]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[223]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[616]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[617]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[618]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[619]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[227]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[620]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]

Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[129]
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[621]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[579]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[239]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[622]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[578]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[429]

Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[623]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[624]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[625]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[626]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[431]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[627]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[628]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[629]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[630]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[523]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[631]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[632]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[633]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[130]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[569]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[634]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[439]
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[590]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]

Drug(s) Affected By Serum paraoxonase/arylesterase 2 (PON2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[635]
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[431]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[636]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[629]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[466]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[637]

Drug(s) Affected By Adiponectin (ADIPOQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[403]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[403]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[638]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[639]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[403]
Cilazapril	DM4V6JA	Congestive heart failure	BD10	Approved	[640]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[641]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[403]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[642]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[643]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[644]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[243]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[307]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[258]
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[645]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[646]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[381]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[647]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[648]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[421]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[649]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[650]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[651]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[652]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[653]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[654]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[512]
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[655]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[656]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[657]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[658]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[659]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[660]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[218]
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[661]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[662]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[307]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[375]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[376]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[375]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[663]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[375]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[398]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[664]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[665]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[666]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[345]
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[667]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[668]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[606]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[573]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[669]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[670]

Drug(s) Affected By Liver carboxylesterase 1 (CES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[671]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[533]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[672]
Selenium	DM25CGV	N. A.	N. A.	Approved	[147]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[673]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[674]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[675]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[676]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[677]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[678]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[679]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[680]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[681]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[682]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[683]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[684]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[685]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[686]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[684]

Drug(s) Affected By Solute carrier organic anion transporter family member 2B1 (SLCO2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[376]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[687]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[277]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[293]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[305]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[688]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[689]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[28]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[267]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[690]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[691]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[692]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[693]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[693]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[694]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[695]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B3 (SLCO1B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[696]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[697]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[694]
Trospium chloride	DM32XZT	Discovery agent	N.A.	Approved	[698]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[176]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[149]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[277]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[278]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[292]

Drug(s) Affected By Sister chromatid cohesion protein DCC1 (DSCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[402]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[227]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[305]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[521]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[699]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[629]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HMG-CoA reductase (HMGCR)	TTPADOQ	HMDH_HUMAN	Inhibitor	[5]
HUMAN MYD88NF-kappa-B proinflammatory pathway (MYD88-NFKB pathway)	TTDJB68	.	Inhibitor	[6]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Monocarboxylate transporter 2 (SLC16A7)	DTLT3UG	MOT2_HUMAN	Substrate	[7]
Monocarboxylate transporter 1 (SLC16A1)	DT342ZG	MOT1_HUMAN	Substrate	[8]
Organic anion transporting polypeptide 2B1 (SLCO2B1)	DTPFTEQ	SO2B1_HUMAN	Substrate	[9]
Organic anion transporting polypeptide 1A2 (SLCO1A2)	DTE2B1D	SO1A2_HUMAN	Substrate	[10]
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[11]
Organic anion transporting polypeptide 1B3 (SLCO1B3)	DT9C1TS	SO1B3_HUMAN	Substrate	[12]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[13]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[14]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Substrate	[15]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[16]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[17]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Substrate	[18]
UDP-glucuronosyltransferase 1A3 (UGT1A3)	DEF2WXN	UD13_HUMAN	Substrate	[19]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[20]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)	OT7TNF0L	AAPK1_HUMAN	Gene/Protein Processing	[21]
Adiponectin (ADIPOQ)	OTNX23LE	ADIPO_HUMAN	Gene/Protein Processing	[22]
Angiopoietin-2 (ANGPT2)	OTEQK65P	ANGP2_HUMAN	Gene/Protein Processing	[23]
Apolipoprotein B-100 (APOB)	OTH0UOCZ	APOB_HUMAN	Gene/Protein Processing	[24]
Apolipoprotein E (APOE)	OTFOWL2H	APOE_HUMAN	Gene/Protein Processing	[25]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[26]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[27]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Gene/Protein Processing	[28]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Regulation of Drug Effects	[29]

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