Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMF28YC)

Drug Name
Atorvastatin Drug Info
Synonyms
Atogal; Atorlip; Atorpic; Atorvastatina; Atorvastatine; Atorvastatinium; Atrovastin; Cardyl; Faboxim; Lipotropic; Lipovastatinklonal; Liprimar; Lowden; Sincol; Sortis; Sotis; Torvacard; Torvast; Totalip; Tozalip; Tulip; Vastina; Xanator; Xarator; Xavator; Zurinel; Atorvastatin (INN); Atorvastatin [INN:BAN]; Lipitor (TN); Lipitor(TM); Sortis (TN); (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid; (3R,5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid; (R-(R*,R*))-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1H-pyrrole-1-heptanoic acid; (betaR,deltaR)-2-(p-Fluorophenyl)-beta,delta-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-1-heptanoic acid; 7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]-3,5-DIHYDROXY-HEPTANOIC ACID
Indication
Disease Entry ICD 11 Status REF
Acute coronary syndrome BA41 Approved [1]
Angina pectoris BA40 Approved [1]
Arteriosclerosis BD40 Approved [1]
Cardiovascular disease BA00-BE2Z Approved [2]
Coronary atherosclerosis Approved [1]
Hypercholesterolaemia 5C80.0 Approved [1]
Hyperlipidemia 5C80.Z Approved [3]
Hyperlipidemia, familial combined, LPL related Approved [1]
Hypertriglyceridemia 5C80.1 Approved [1]
Inflammation 1A00-CA43.1 Approved [1]
Non-insulin dependent diabetes 5A11 Approved [1]
Psoriasis EA90 Approved [1]
Type-1/2 diabetes 5A10-5A11 Approved [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [4]
Stroke 8B20 Investigative [1]
Venous thromboembolism BD72 Investigative [1]
Therapeutic Class
Anticholesteremic Agents
Cross-matching ID
PubChem CID
60823
ChEBI ID
CHEMBL1487
CAS Number
CAS 134523-00-5
TTD Drug ID
DMF28YC
VARIDT Drug ID
DR00030
INTEDE Drug ID
DR0155
ACDINA Drug ID
D00050

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting HMG-CoA reductase (HMGCR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [30]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [31]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [32]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [33]
Fluvastatin DM4MDJY Arteriosclerosis BD40 Approved [5]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [34]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [5]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [35]
Teriflunomide DMQ2FKJ Hyperlipidaemia 5C80 Approved [34]
TOCOTRIENOL DM1UE67 Hyperlipidaemia 5C80 Approved [36]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [37]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [38]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
Folic Acid DMEMBJC Colorectal carcinoma Approved [40]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [39]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [41]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [39]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [42]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [43]
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Drug(s) Transported By Organic anion transporting polypeptide 1B1 (SLCO1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [44]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [45]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [46]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [47]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [46]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [48]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [49]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [12]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [48]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [50]
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Drug(s) Transported By Organic anion transporting polypeptide 1A2 (SLCO1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [52]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [53]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [54]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [55]
Saquinavir DMG814N Human immunodeficiency virus infection 1C62 Approved [56]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [57]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [58]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [59]
Labetalol DMK8U72 Hypertension BA00-BA04 Approved [60]
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Drug(s) Transported By Organic anion transporting polypeptide 1B3 (SLCO1B3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [46]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [62]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [63]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [46]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [64]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [49]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [65]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [12]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [66]
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Drug(s) Transported By Organic anion transporting polypeptide 2B1 (SLCO2B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [67]
L-Glutamic Acid DM4PUDW Schizophrenia 6A20 Approved [68]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [69]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [47]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [70]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [71]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [72]
Digoxin DMQCTIH Arrhythmia BC9Z Approved [73]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [50]
Fluvastatin DM4MDJY Arteriosclerosis BD40 Approved [74]
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Drug(s) Transported By Monocarboxylate transporter 1 (SLC16A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [75]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [8]
Gamma Hydroxybutyric Acid DMGBKVD Narcolepsy 7A20 Approved [76]
Pyruvic acid DM7Q41G Malnutrition 5B50-5B71 Approved [77]
Gabapentin enacarbil DMJY2TM Postherpetic neuralgia 1E91.5 Phase 2 [78]
Pyroglutamic Acid DMROZUA Discovery agent N.A. Investigative [79]
Butanoic Acid DMTAJP7 Discovery agent N.A. Investigative [78]
Hydroxyacetic Acid DMQFBH6 Discovery agent N.A. Investigative [80]
biotin DMKMCE1 Discovery agent N.A. Investigative [81]
Milchsaure DM462BT Pruritus EC90 Investigative [82]
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Drug(s) Transported By Monocarboxylate transporter 2 (SLC16A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [7]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [7]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [83]
Quercetin DM3NC4M Obesity 5B81 Approved [7]
Propicillin DMWDHUZ Bacterial infection 1A00-1C4Z Approved [7]
Milchsaure DM462BT Pruritus EC90 Investigative [84]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [85]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [86]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [87]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [88]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [89]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [90]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [91]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [92]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [86]
Verapamil DMA7PEW Angina pectoris BA40 Approved [14]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [93]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [94]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [95]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [96]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [97]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [98]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [99]
Metronidazole DMTIVEN Abscess Approved [100]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [101]
Ethanol DMDRQZU Chronic pain MG30 Approved [102]
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Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [103]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [104]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [105]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [106]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [107]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [108]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [109]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [110]
Verapamil DMA7PEW Angina pectoris BA40 Approved [111]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [106]
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Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [112]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [106]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [106]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [106]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [113]
Verapamil DMA7PEW Angina pectoris BA40 Approved [114]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [106]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [106]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [106]
Metronidazole DMTIVEN Abscess Approved [115]
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Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [116]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [17]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [17]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [113]
Verapamil DMA7PEW Angina pectoris BA40 Approved [117]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [118]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [119]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [17]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [120]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [121]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A3 (UGT1A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [122]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [98]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [14]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [123]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [124]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [125]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [126]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [127]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [14]
Naproxen DMZ5RGV Bursitis Approved [128]
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Drug(s) Affected By Stromelysin-1 (MMP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [129]
Fluvastatin DM4MDJY Arteriosclerosis BD40 Approved [129]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [129]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [130]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [131]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [132]
Methotrexate DM2TEOL Anterior urethra cancer Approved [133]
Quercetin DM3NC4M Obesity 5B81 Approved [134]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
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Drug(s) Affected By Kinesin-like protein KIF6 (KIF6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [137]
Arsenic DMTL2Y1 N. A. N. A. Approved [138]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [139]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [140]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [141]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [142]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [142]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [142]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [140]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [143]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [144]
Quercetin DM3NC4M Obesity 5B81 Approved [145]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [146]
Artemether DM48QOT Malaria 1F40-1F45 Approved [147]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [149]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [150]
Estrone DM5T6US Acne vulgaris ED80 Approved [151]
Leflunomide DMR8ONJ Arthritis FA20 Approved [152]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
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Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [155]
Quercetin DM3NC4M Obesity 5B81 Approved [156]
Fluoxetine DM3PD2C Bipolar depression Approved [157]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [158]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [159]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [160]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [162]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [163]
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Drug(s) Affected By Sterol 26-hydroxylase, mitochondrial (CYP27A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [164]
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [158]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [165]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [166]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [168]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [169]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [171]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [172]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [172]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [173]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [171]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [172]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [174]
Gefitinib DM15F0X Colon adenocarcinoma Approved [171]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [23]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [171]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [175]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [175]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [176]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [177]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [178]
Etidronic acid DM1XHYJ Bone Paget disease Approved [175]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [175]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [175]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [144]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [179]
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Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [180]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [181]
Methotrexate DM2TEOL Anterior urethra cancer Approved [182]
Quercetin DM3NC4M Obesity 5B81 Approved [156]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [184]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [185]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Folic Acid DMEMBJC Colorectal carcinoma Approved [186]
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Drug(s) Affected By Hexokinase-4 (GCK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [187]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [188]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [189]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [190]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Folic Acid DMEMBJC Colorectal carcinoma Approved [191]
Arsenic DMTL2Y1 N. A. N. A. Approved [192]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [193]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [194]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [195]
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Drug(s) Affected By Prothrombin (F2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [196]
Methotrexate DM2TEOL Anterior urethra cancer Approved [197]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [198]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [200]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [201]
Phytonadione DM8HDOL Bleeding disorder GA20-GA21 Approved [202]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Testosterone enanthate DMB6871 N. A. N. A. Approved [203]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [205]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [206]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [207]
Gefitinib DM15F0X Colon adenocarcinoma Approved [208]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [209]
Selenium DM25CGV N. A. N. A. Approved [210]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [211]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [212]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [213]
Methotrexate DM2TEOL Anterior urethra cancer Approved [197]
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Drug(s) Affected By Interleukin-2 receptor subunit alpha (IL2RA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [182]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [214]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [215]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [216]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [217]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [218]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [219]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Folic Acid DMEMBJC Colorectal carcinoma Approved [191]
Clozapine DMFC71L Schizophrenia 6A20 Approved [220]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [129]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [221]
Diazepam DM08E9O Alcohol withdrawal Approved [222]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [223]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Methotrexate DM2TEOL Anterior urethra cancer Approved [225]
Ceruletide DM2WE5K Caerulein stimulated gastric and pancreatic secretion 5A4Y Approved [226]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [227]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [228]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-reactive protein (CRP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [129]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [230]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [231]
Quercetin DM3NC4M Obesity 5B81 Approved [232]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [158]
Acalabrutinib DM7GCVW leukaemia 2A60-2B33 Approved [233]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [234]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [235]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [236]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
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Drug(s) Affected By Osteocalcin (BGLAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [237]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [238]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [239]
Quercetin DM3NC4M Obesity 5B81 Approved [156]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [240]
Pamidronate DMB4AVP Bone Paget disease Approved [241]
Falecalcitrol DMBI9ZJ Hyperparathyroidism 5A51 Approved [242]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [243]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [244]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [245]
Selenium DM25CGV N. A. N. A. Approved [246]
Methotrexate DM2TEOL Anterior urethra cancer Approved [247]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [248]
Epinephrine DM3KJBC Acute asthma CA23 Approved [249]
Quercetin DM3NC4M Obesity 5B81 Approved [250]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [251]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [158]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [252]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [206]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [253]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [254]
Quercetin DM3NC4M Obesity 5B81 Approved [156]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [255]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [256]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [257]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [258]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [259]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [260]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho-related GTP-binding protein RhoC (RHOC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [198]
Quercetin DM3NC4M Obesity 5B81 Approved [156]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [261]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [262]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [263]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [264]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [266]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [267]
Terbinafine DMI6HUW Fungal infection 1F29-1F2F Approved [268]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [269]
Gefitinib DM15F0X Colon adenocarcinoma Approved [270]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [271]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [272]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [273]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [274]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [273]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [275]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [276]
Methotrexate DM2TEOL Anterior urethra cancer Approved [277]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [278]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [279]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [280]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [281]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [282]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [283]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [284]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [285]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [286]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [284]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [287]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [288]
Gefitinib DM15F0X Colon adenocarcinoma Approved [289]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [290]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [291]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [292]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [293]
Methotrexate DM2TEOL Anterior urethra cancer Approved [197]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [24]
Quercetin DM3NC4M Obesity 5B81 Approved [294]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [129]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [295]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [296]
Methotrexate DM2TEOL Anterior urethra cancer Approved [182]
Quercetin DM3NC4M Obesity 5B81 Approved [297]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [298]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [299]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [300]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [301]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [302]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin alpha-X (ITGAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [303]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [304]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [305]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [168]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [306]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [307]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [308]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [308]
Ardeparin DMYRX8B Deep vein thrombosis BD71 Approved [309]
Bryostatin-1 DM1JOXY Alzheimer disease 8A20 Phase 2 [310]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 5 (CD40)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [130]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [27]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [312]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [313]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [314]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [137]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [315]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [316]
Menthol DMG2KW7 Back pain ME84.Z Approved [317]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [318]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [319]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [320]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [321]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [322]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [323]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [324]
Gefitinib DM15F0X Colon adenocarcinoma Approved [325]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [326]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [327]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [328]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [319]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [329]
Paclitaxel DMLB81S Breast carcinoma Approved [330]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [331]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [318]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [129]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [130]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [321]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [322]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-12 subunit alpha (IL12A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [332]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [333]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [334]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [335]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [336]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [337]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [338]
Arsenic DMTL2Y1 N. A. N. A. Approved [339]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [340]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD40 ligand (CD40LG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [290]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [312]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [341]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [342]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [343]
Menthol DMG2KW7 Back pain ME84.Z Approved [317]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [344]
Eptifibatide DMQXTJS Acute cardiac ischemic events BA40.Z Approved [345]
Candesartan DMRK8OT Chronic heart failure BD1Z Approved [343]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [346]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [347]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [348]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [349]
Gefitinib DM15F0X Colon adenocarcinoma Approved [350]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [351]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [352]
Etretinate DM2CZFA Keratosis ED56 Approved [353]
Prednisone DM2HG4X Acute asthma CA23 Approved [354]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [274]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [355]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [130]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [356]
Quercetin DM3NC4M Obesity 5B81 Approved [156]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [300]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [357]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [185]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [358]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [267]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [359]
Gefitinib DM15F0X Colon adenocarcinoma Approved [360]
Prednisone DM2HG4X Acute asthma CA23 Approved [354]
Methotrexate DM2TEOL Anterior urethra cancer Approved [361]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [362]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [363]
Quercetin DM3NC4M Obesity 5B81 Approved [364]
Fluoxetine DM3PD2C Bipolar depression Approved [365]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [366]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [367]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [368]
Gefitinib DM15F0X Colon adenocarcinoma Approved [369]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [370]
Epinephrine DM3KJBC Acute asthma CA23 Approved [371]
Quercetin DM3NC4M Obesity 5B81 Approved [372]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [373]
Fructose DM43AN2 Vomiting MD90 Approved [374]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [375]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [376]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [377]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Importin subunit alpha-1 (KPNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [253]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [181]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [378]
Testosterone DM7HUNW Hot flushes GA30 Approved [379]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [380]
Leflunomide DMR8ONJ Arthritis FA20 Approved [381]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [382]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [267]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [383]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Microsomal triglyceride transfer protein large subunit (MTTP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [384]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [384]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [385]
Quercetin DM3NC4M Obesity 5B81 Approved [156]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [384]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [384]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [385]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [386]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [137]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho-related GTP-binding protein RhoB (RHOB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [387]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [165]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [165]
Panobinostat DM58WKG Chronic graft versus host disease Approved [388]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [263]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [389]
Leflunomide DMR8ONJ Arthritis FA20 Approved [381]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [390]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [137]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [130]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [391]
Gefitinib DM15F0X Colon adenocarcinoma Approved [270]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [392]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [393]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [394]
Methotrexate DM2TEOL Anterior urethra cancer Approved [197]
Quercetin DM3NC4M Obesity 5B81 Approved [156]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [395]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [396]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD83 antigen (CD83)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [397]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [156]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [387]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [264]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [398]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [399]
Leflunomide DMR8ONJ Arthritis FA20 Approved [381]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [129]
Selenium DM25CGV N. A. N. A. Approved [400]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [401]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [158]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [261]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [402]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [403]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [404]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [405]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [406]
Quercetin DM3NC4M Obesity 5B81 Approved [407]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [408]
Testosterone DM7HUNW Hot flushes GA30 Approved [409]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [267]
Capsaicin DMGMF6V Back pain ME84.Z Approved [410]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [411]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [412]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [413]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [338]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [414]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [415]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [416]
Methotrexate DM2TEOL Anterior urethra cancer Approved [417]
Quercetin DM3NC4M Obesity 5B81 Approved [418]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [261]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [419]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [420]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [421]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [422]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [423]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [206]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [384]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [356]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [384]
Quercetin DM3NC4M Obesity 5B81 Approved [424]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [384]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [258]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [425]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [426]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [427]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [223]
Selenium DM25CGV N. A. N. A. Approved [400]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [428]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [429]
Methotrexate DM2TEOL Anterior urethra cancer Approved [397]
Quercetin DM3NC4M Obesity 5B81 Approved [156]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [373]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [430]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [431]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [432]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [433]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [434]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [435]
Cepharanthine DM9Y5JB N. A. N. A. Approved [436]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [437]
Clozapine DMFC71L Schizophrenia 6A20 Approved [438]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [439]
Trifluoperazine DMKBYWI Anxiety Approved [440]
Olanzapine DMPFN6Y Bipolar depression Approved [438]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier organic anion transporter family member 2B1 (SLCO2B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [356]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [441]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [184]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [442]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [168]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [442]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ethanol DMDRQZU Chronic pain MG30 Approved [443]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier organic anion transporter family member 1B1 (SLCO1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Enalapril DMNFUZR Congestive heart failure BD10 Approved [444]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [445]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [173]
Repaglinide DM5SXUV Diabetic complication 5A2Y Approved [446]
Methotrexate DM2TEOL Anterior urethra cancer Approved [447]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [448]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [449]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [449]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [450]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [451]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier organic anion transporter family member 1B3 (SLCO1B3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [452]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [453]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [450]
Trospium chloride DM32XZT Discovery agent N.A. Approved [454]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [455]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [158]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [183]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [455]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [185]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [456]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sister chromatid cohesion protein DCC1 (DSCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [269]
Quercetin DM3NC4M Obesity 5B81 Approved [156]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Testosterone DM7HUNW Hot flushes GA30 Approved [379]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [379]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [336]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [457]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [412]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
HMG-CoA reductase (HMGCR) TTPADOQ HMDH_HUMAN Inhibitor [5]
HUMAN MYD88NF-kappa-B proinflammatory pathway (MYD88-NFKB pathway) TTDJB68 . Inhibitor [6]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Monocarboxylate transporter 2 (SLC16A7) DTLT3UG MOT2_HUMAN Substrate [7]
Monocarboxylate transporter 1 (SLC16A1) DT342ZG MOT1_HUMAN Substrate [8]
Organic anion transporting polypeptide 2B1 (SLCO2B1) DTPFTEQ SO2B1_HUMAN Substrate [9]
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [10]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [11]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [12]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [13]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [14]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [15]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [16]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [17]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Substrate [18]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DEF2WXN UD13_HUMAN Substrate [19]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) OT7TNF0L AAPK1_HUMAN Gene/Protein Processing [20]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Regulation of Drug Effects [21]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Gene/Protein Processing [22]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [23]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [24]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Gene/Protein Processing [25]
CD40 ligand (CD40LG) OT75Z6A6 CD40L_HUMAN Gene/Protein Processing [26]
CD83 antigen (CD83) OT1V4WQF CD83_HUMAN Gene/Protein Processing [27]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Gene/Protein Processing [28]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [29]

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111 Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil. Drug Metab Dispos. 2005 May;33(5):664-71.
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