Details of the Drug Combination

General Information of Drug Combination (ID: DCOHPQV)

Drug Combination Name
Cytarabine Clindamycin
Indication
Disease Entry Status REF
Chronic myelogenous leukemia Investigative [1]
Component Drugs Cytarabine   DMZD5QR Clindamycin   DM15HL8
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: KBM-7
Zero Interaction Potency (ZIP) Score: 1.85
Bliss Independence Score: 1.85
Loewe Additivity Score: 2.18
LHighest Single Agent (HSA) Score: 2.19

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Cytarabine
Disease Entry ICD 11 Status REF
Acute lymphoblastic leukaemia 2A85 Approved [2]
Acute myelogenous leukaemia 2A41 Approved [3]
Adult acute monocytic leukemia N.A. Approved [3]
Childhood acute megakaryoblastic leukemia N.A. Approved [3]
Plasma cell myeloma 2A83.1 Approved [3]
Neoplastic meningitis N.A. Investigative [3]
Cytarabine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Herpes simplex virus DNA polymerase UL30 (HSV UL30) TTIU7X1 DPOL_HHV11 Inhibitor [13]
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Cytarabine Interacts with 6 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [14]
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [15]
Organic cation/carnitine transporter 1 (SLC22A4) DT2EG60 S22A4_HUMAN Substrate [16]
Concentrative nucleoside transporter 1 (SLC28A1) DT0EQPW S28A1_HUMAN Substrate [17]
Equilibrative nucleoside transporter 1 (SLC29A1) DTXD1TQ S29A1_HUMAN Substrate [17]
Equilibrative nucleoside transporter 2 (SLC29A2) DTW78DQ S29A2_HUMAN Substrate [17]
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⏷ Show the Full List of 6 DTP(s)
Cytarabine Interacts with 5 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [18]
Cytidine aminohydrolase (CDA) DEKEDRC CDD_HUMAN Metabolism [19]
Ecto-5'-nucleotidase (NT5E) DE3Z9HM 5NTD_HUMAN Metabolism [19]
Deoxycytidylate deaminase (DCTD) DEXL3P2 DCTD_HUMAN Metabolism [19]
Cytidine deaminase (cdd) DEYILK4 E0TLJ6_MYCHH Metabolism [20]
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Cytarabine Interacts with 549 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [21]
Equilibrative nucleoside transporter 1 (SLC29A1) OTLOOZZS S29A1_HUMAN Decreases Response To Substance [22]
GTP-binding protein 1 (GTPBP1) OTA9KV6C GTPB1_HUMAN Increases Expression [6]
Kinetochore protein NDC80 homolog (NDC80) OTS7D306 NDC80_HUMAN Increases Expression [6]
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) OTIFVXWD PDE6D_HUMAN Decreases Expression [6]
Lymphocyte antigen 75 (LY75) OTDHBU0N LY75_HUMAN Increases Expression [6]
ATP-dependent DNA helicase Q5 (RECQL5) OTVZMP1Q RECQ5_HUMAN Decreases Expression [6]
SLIT and NTRK-like protein 5 (SLITRK5) OTTSUSB8 SLIK5_HUMAN Decreases Expression [6]
Dihydrofolate reductase (DHFR) OT3DVIGM DYR_HUMAN Increases Expression [6]
Alpha-1-antitrypsin (SERPINA1) OTACYW9J A1AT_HUMAN Increases Expression [6]
T-cell surface glycoprotein CD8 alpha chain (CD8A) OTDWQJXK CD8A_HUMAN Increases Expression [6]
Thy-1 membrane glycoprotein (THY1) OTVONVTB THY1_HUMAN Decreases Expression [6]
Serglycin (SRGN) OTFAVSX0 SRGN_HUMAN Increases Expression [6]
Non-secretory ribonuclease (RNASE2) OT8Z4FNE RNAS2_HUMAN Increases Expression [6]
Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A) OT0OUDUT FCG2A_HUMAN Increases Expression [6]
Heat shock 70 kDa protein 6 (HSPA6) OTH4S7WB HSP76_HUMAN Increases Expression [6]
Transcription factor E3 (TFE3) OTM99ZWH TFE3_HUMAN Increases Expression [6]
Protein S100-P (S100P) OTJCXNJG S100P_HUMAN Increases Expression [6]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) OTOB6J6R RIR2_HUMAN Increases Expression [6]
Low affinity immunoglobulin gamma Fc region receptor II-c (FCGR2C) OTNLMNYB FCG2C_HUMAN Increases Expression [6]
G protein-coupled receptor kinase 5 (GRK5) OTJK79EK GRK5_HUMAN Increases Expression [6]
RNA-binding protein 34 (RBM34) OTX3LUGI RBM34_HUMAN Decreases Expression [6]
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) OT6E2OW6 ENTP1_HUMAN Increases Expression [6]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Expression [6]
Breast cancer type 2 susceptibility protein (BRCA2) OTF1XSV1 BRCA2_HUMAN Increases Expression [6]
Geranylgeranyl transferase type-2 subunit beta (RABGGTB) OTZ25I2W PGTB2_HUMAN Decreases Expression [6]
UV excision repair protein RAD23 homolog A (RAD23A) OTBPAWHX RD23A_HUMAN Decreases Expression [6]
Ras-related protein Rab-5B (RAB5B) OT06PN42 RAB5B_HUMAN Increases Expression [6]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Increases Expression [6]
Lysozyme C (LYZ) OTD7H0G6 LYSC_HUMAN Increases Expression [6]
Histone H4 (H4C1) OTB71W46 H4_HUMAN Decreases Expression [6]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Increases Expression [6]
Dual specificity protein phosphatase 4 (DUSP4) OT6WAO12 DUS4_HUMAN Decreases Expression [6]
Src-like-adapter (SLA) OTV17DY2 SLAP1_HUMAN Increases Expression [6]
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (ACAP1) OTPFQ2QC ACAP1_HUMAN Increases Expression [6]
Cytohesin-1 (CYTH1) OTYH9NRJ CYH1_HUMAN Increases Expression [6]
C3a anaphylatoxin chemotactic receptor (C3AR1) OT8J0TF8 C3AR_HUMAN Increases Expression [6]
Drebrin (DBN1) OTZVKG8A DREB_HUMAN Decreases Expression [6]
DALR anticodon-binding domain-containing protein 3 (DALRD3) OTU79VIP DALD3_HUMAN Decreases Expression [6]
Equilibrative nucleobase transporter 1 (SLC43A3) OTR60ZLA S43A3_HUMAN Increases Expression [6]
Glutathione S-transferase C-terminal domain-containing protein (GSTCD) OTIIINMT GSTCD_HUMAN Increases Expression [6]
DENN domain-containing protein 1A (DENND1A) OTONDAA0 DEN1A_HUMAN Increases Expression [6]
Serine protease FAM111A (FAM111A) OTVLARLG F111A_HUMAN Increases Expression [6]
Proline-serine-threonine phosphatase-interacting protein 2 (PSTPIP2) OTG6F93V PPIP2_HUMAN Decreases Expression [6]
Partitioning defective 6 homolog alpha (PARD6A) OTWLV3X1 PAR6A_HUMAN Decreases Expression [6]
Mediator of RNA polymerase II transcription subunit 9 (MED9) OT59OKEJ MED9_HUMAN Decreases Expression [6]
Phospholipid-transporting ATPase VD (ATP10D) OT3JPE4H AT10D_HUMAN Increases Expression [6]
Bridging integrator 2 (BIN2) OT4S45WJ BIN2_HUMAN Increases Expression [6]
DNA dC->dU-editing enzyme APOBEC-3B (APOBEC3B) OTHLNI51 ABC3B_HUMAN Increases Expression [6]
Protein PRRC2C (PRRC2C) OTBX3MXM PRC2C_HUMAN Decreases Expression [6]
Odontogenic ameloblast-associated protein (ODAM) OTT666SJ ODAM_HUMAN Decreases Expression [7]
Pleckstrin homology domain-containing family G member 3 (PLEKHG3) OTF6I8RV PKHG3_HUMAN Decreases Expression [7]
Aldo-keto reductase family 1 member B15 (AKR1B15) OTUEXSWH AK1BF_HUMAN Decreases Expression [7]
Alternative prion protein (PRNP) OTE85L1Q APRIO_HUMAN Decreases Expression [7]
Matrilin-2 (MATN2) OTVDR68G MATN2_HUMAN Decreases Expression [7]
Homeobox protein Meis1 (MEIS1) OTH9DKAD MEIS1_HUMAN Increases Expression [7]
Gamma-aminobutyric acid receptor subunit pi (GABRP) OTGKA8WS GBRP_HUMAN Increases Expression [7]
Podocalyxin (PODXL) OTPNQXF3 PODXL_HUMAN Decreases Expression [7]
Sarcolipin (SLN) OTERIU75 SARCO_HUMAN Decreases Expression [7]
Nuclear factor 1 B-type (NFIB) OTX94PD0 NFIB_HUMAN Increases Expression [7]
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF1) OTFK8KDP NHRF1_HUMAN Decreases Expression [7]
Heparan sulfate glucosamine 3-O-sulfotransferase 1 (HS3ST1) OT5DVN9P HS3S1_HUMAN Decreases Expression [7]
Tetraspanin-4 (TSPAN4) OTKFK57F TSN4_HUMAN Decreases Expression [7]
Regulator of G-protein signaling 13 (RGS13) OTPAMQ18 RGS13_HUMAN Decreases Expression [7]
Surfeit locus protein 4 (SURF4) OTCSXJ9C SURF4_HUMAN Decreases Expression [7]
Monocarboxylate transporter 4 (SLC16A3) OTDIXEXY MOT4_HUMAN Decreases Expression [7]
Prolyl 4-hydroxylase subunit alpha-2 (P4HA2) OTP45YKX P4HA2_HUMAN Decreases Expression [7]
Glycogenin-2 (GYG2) OTAJ7YEW GLYG2_HUMAN Decreases Expression [7]
Fatty acid-binding protein, brain (FABP7) OTRE2H4G FABP7_HUMAN Increases Expression [7]
Leucine-rich repeat transmembrane protein FLRT2 (FLRT2) OTGD8TID FLRT2_HUMAN Decreases Expression [7]
SLIT-ROBO Rho GTPase-activating protein 3 (SRGAP3) OT9ZS72C SRGP3_HUMAN Increases Expression [7]
Homeobox protein Hox-A2 (HOXA2) OT6G6ZIK HXA2_HUMAN Increases Expression [7]
Mothers against decapentaplegic homolog 6 (SMAD6) OTUZZWUD SMAD6_HUMAN Decreases Expression [7]
Carbonic anhydrase 12 (CA12) OT6WNFU8 CAH12_HUMAN Decreases Expression [7]
Zinc finger protein SNAI2 (SNAI2) OT7Y8EJ2 SNAI2_HUMAN Decreases Expression [7]
Transcription factor 21 (TCF21) OT393IMA TCF21_HUMAN Decreases Expression [7]
ER lumen protein-retaining receptor 3 (KDELR3) OTW8C1V0 ERD23_HUMAN Decreases Expression [7]
Adhesion G protein-coupled receptor B3 (ADGRB3) OT1EWGRW AGRB3_HUMAN Increases Expression [7]
Protocadherin-7 (PCDH7) OTP091X8 PCDH7_HUMAN Decreases Expression [7]
Suppression of tumorigenicity 18 protein (ST18) OTPRIMTA ST18_HUMAN Increases Expression [7]
TBC1 domain family member 4 (TBC1D4) OTK66C40 TBCD4_HUMAN Decreases Expression [7]
Protein-tyrosine sulfotransferase 1 (TPST1) OTDPQKEA TPST1_HUMAN Decreases Expression [7]
Clathrin coat assembly protein AP180 (SNAP91) OTE3EXWZ AP180_HUMAN Increases Expression [7]
Kelch-like protein 41 (KLHL41) OTLABE56 KLH41_HUMAN Decreases Expression [7]
Perilipin-3 (PLIN3) OT9ZA7MR PLIN3_HUMAN Decreases Expression [7]
P antigen family member 4 (PAGE4) OT2VLWT0 PAGE4_HUMAN Decreases Expression [7]
Receptor activity-modifying protein 1 (RAMP1) OT7UT2XB RAMP1_HUMAN Decreases Expression [7]
Phosphatase and actin regulator 2 (PHACTR2) OTWMX2A8 PHAR2_HUMAN Decreases Expression [7]
Leucine-rich repeat neuronal protein 2 (LRRN2) OTGP2DCY LRRN2_HUMAN Decreases Expression [7]
Cartilage-associated protein (CRTAP) OT53H5U6 CRTAP_HUMAN Decreases Expression [7]
Breast cancer anti-estrogen resistance protein 3 (BCAR3) OTPJ17M8 BCAR3_HUMAN Decreases Expression [7]
Matrix metalloproteinase-23 (MMP23B) OT2OR6TS MMP23_HUMAN Decreases Expression [7]
Regulator of G-protein signaling 20 (RGS20) OT6CGYHW RGS20_HUMAN Increases Expression [7]
Lymphocyte antigen 6H (LY6H) OTTFGUD2 LY6H_HUMAN Decreases Expression [7]
Slit homolog 2 protein (SLIT2) OTLS2RJ4 SLIT2_HUMAN Decreases Expression [7]
Sorbin and SH3 domain-containing protein 2 (SORBS2) OTJSX44Y SRBS2_HUMAN Increases Expression [7]
Glutaminase kidney isoform, mitochondrial (GLS) OTGOZG2M GLSK_HUMAN Decreases Expression [7]
SLIT and NTRK-like protein 3 (SLITRK3) OT018P93 SLIK3_HUMAN Decreases Expression [7]
Myelin protein zero-like protein 1 (MPZL1) OTJSUUHR MPZL1_HUMAN Decreases Expression [7]
BAG family molecular chaperone regulator 3 (BAG3) OTVXYUDQ BAG3_HUMAN Decreases Expression [7]
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) OT0I2B4J FBLN4_HUMAN Decreases Expression [7]
Heart- and neural crest derivatives-expressed protein 1 (HAND1) OTN4IPVV HAND1_HUMAN Decreases Expression [7]
G1/S-specific cyclin-E2 (CCNE2) OTBBUKQQ CCNE2_HUMAN Increases Expression [7]
Cytochrome b5 (CYB5A) OT6SN4RM CYB5_HUMAN Decreases Expression [7]
Tissue-type plasminogen activator (PLAT) OTQPDNAB TPA_HUMAN Decreases Expression [7]
Serine protease inhibitor Kazal-type 1 (SPINK1) OTSUVAL2 ISK1_HUMAN Increases Expression [7]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Decreases Expression [7]
Pro-neuropeptide Y (NPY) OT4ICV3P NPY_HUMAN Decreases Expression [7]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Decreases Expression [7]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Decreases Expression [7]
Alpha-crystallin B chain (CRYAB) OTY4JGYU CRYAB_HUMAN Decreases Expression [7]
Metallothionein-2 (MT2A) OTHOACHD MT2_HUMAN Decreases Expression [7]
Metallothionein-1A (MT1A) OTKBH52X MT1A_HUMAN Decreases Expression [7]
Metallothionein-1E (MT1E) OTXJKU4Y MT1E_HUMAN Decreases Expression [7]
Sodium/potassium-transporting ATPase subunit beta-1 (ATP1B1) OTTO6ZP4 AT1B1_HUMAN Decreases Expression [7]
Keratin, type II cytoskeletal 8 (KRT8) OTTM4X11 K2C8_HUMAN Decreases Expression [7]
Collagen alpha-2(V) chain (COL5A2) OT5VOSQE CO5A2_HUMAN Decreases Expression [7]
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Increases Expression [7]
Tyrosine 3-monooxygenase (TH) OT6ZORKP TY3H_HUMAN Decreases Expression [7]
Annexin A2 (ANXA2) OTFNS0CC ANXA2_HUMAN Decreases Expression [7]
Calpain-1 catalytic subunit (CAPN1) OTK6OQZR CAN1_HUMAN Decreases Expression [7]
Decorin (DCN) OTWLJL7K PGS2_HUMAN Decreases Expression [7]
Procathepsin L (CTSL) OTYTUW29 CATL1_HUMAN Decreases Expression [7]
Tyrosine-protein kinase Lyn (LYN) OTP686K2 LYN_HUMAN Decreases Expression [7]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Increases Expression [7]
Collagen alpha-2(I) chain (COL1A2) OTY7G382 CO1A2_HUMAN Decreases Expression [7]
Annexin A6 (ANXA6) OT9KIQ0Y ANXA6_HUMAN Decreases Expression [7]
Rho-related GTP-binding protein RhoC (RHOC) OTOLE1FT RHOC_HUMAN Decreases Expression [7]
Matrix Gla protein (MGP) OTZWU3FU MGP_HUMAN Decreases Expression [7]
Keratin, type I cytoskeletal 19 (KRT19) OTDGDQ75 K1C19_HUMAN Decreases Expression [7]
SPARC (SPARC) OTPN90H0 SPRC_HUMAN Decreases Expression [7]
Platelet-derived growth factor receptor beta (PDGFRB) OTYSNK9Q PGFRB_HUMAN Decreases Expression [7]
Homeobox protein Hox-C6 (HOXC6) OTBCRAZV HXC6_HUMAN Decreases Expression [7]
Pro-cathepsin H (CTSH) OTLFL0DG CATH_HUMAN Decreases Expression [7]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) OTXOQDSG IFIT1_HUMAN Decreases Expression [7]
Thymosin beta-15A (TMSB15A) OTSBWCES TB15A_HUMAN Increases Expression [7]
Ras-related protein R-Ras (RRAS) OTBBF28C RRAS_HUMAN Decreases Expression [7]
Tissue factor pathway inhibitor (TFPI) OTA0FX16 TFPI1_HUMAN Decreases Expression [7]
Growth hormone receptor (GHR) OT8WUWMU GHR_HUMAN Decreases Expression [7]
Hyaluronan and proteoglycan link protein 1 (HAPLN1) OTXWR9TJ HPLN1_HUMAN Decreases Expression [7]
Microtubule-associated protein 2 (MAP2) OT6UYT3X MTAP2_HUMAN Increases Expression [7]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Decreases Expression [7]
Collagen alpha-2(VI) chain (COL6A2) OTQC6PPO CO6A2_HUMAN Decreases Expression [7]
Collagen alpha-3(VI) chain (COL6A3) OTAS6R6I CO6A3_HUMAN Decreases Expression [7]
Creatine kinase B-type (CKB) OTUCKOTT KCRB_HUMAN Increases Expression [7]
Bone morphogenetic protein 4 (BMP4) OTPZMDFH BMP4_HUMAN Decreases Expression [7]
Myosin light chain 4 (MYL4) OTURFCSE MYL4_HUMAN Decreases Expression [7]
Cytochrome b-245 light chain (CYBA) OT16N9ZO CY24A_HUMAN Decreases Expression [7]
Elongation factor 2 (EEF2) OTZ7SZ39 EF2_HUMAN Decreases Expression [7]
Annexin A8 (ANXA8) OTLSSQCY ANXA8_HUMAN Decreases Expression [7]
Beta-enolase (ENO3) OT3HYKYI ENOB_HUMAN Decreases Expression [7]
Ezrin (EZR) OTHBPF1Z EZRI_HUMAN Decreases Expression [7]
N-chimaerin (CHN1) OTM196M3 CHIN_HUMAN Decreases Expression [7]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Decreases Expression [7]
Histone H1.2 (H1-2) OT0AVI4M H12_HUMAN Decreases Expression [7]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (GNB3) OTA6HYBA GBB3_HUMAN Decreases Expression [7]
Natriuretic peptides B (NPPB) OTSN2IPY ANFB_HUMAN Increases Expression [7]
Homeobox protein Hox-B8 (HOXB8) OTKHOD17 HXB8_HUMAN Decreases Expression [7]
Homeobox protein Hox-B4 (HOXB4) OTH1HRW5 HXB4_HUMAN Decreases Expression [7]
Homeobox protein Hox-B6 (HOXB6) OT3TFQ0U HXB6_HUMAN Decreases Expression [7]
Neuromodulin (GAP43) OT2OTGGV NEUM_HUMAN Increases Expression [7]
Insulin-like growth factor-binding protein 3 (IGFBP3) OTIX63TX IBP3_HUMAN Decreases Expression [7]
Integrin beta-5 (ITGB5) OT21MF51 ITB5_HUMAN Decreases Expression [7]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Decreases Expression [7]
Protachykinin-1 (TAC1) OTM842YW TKN1_HUMAN Increases Expression [7]
Homeobox protein Hox-A5 (HOXA5) OTLWGPQD HXA5_HUMAN Increases Expression [7]
Ephrin-A1 (EFNA1) OTU2NUA2 EFNA1_HUMAN Decreases Expression [7]
Collagen alpha-1(IX) chain (COL9A1) OTWBR27Y CO9A1_HUMAN Increases Expression [7]
Collagen alpha-1(V) chain (COL5A1) OT24078H CO5A1_HUMAN Decreases Expression [7]
Cannabinoid receptor 1 (CNR1) OTEALO6G CNR1_HUMAN Increases Expression [7]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) OTVLI4DD TNAP3_HUMAN Decreases Expression [7]
Midkine (MDK) OTF24HKC MK_HUMAN Decreases Expression [7]
Bone morphogenetic protein 5 (BMP5) OTC0Y6E0 BMP5_HUMAN Decreases Expression [7]
Cadherin-3 (CDH3) OTKNLQU7 CADH3_HUMAN Decreases Expression [7]
Calretinin (CALB2) OTSNMCG9 CALB2_HUMAN Decreases Expression [7]
Fibulin-1 (FBLN1) OT5MHHOP FBLN1_HUMAN Decreases Expression [7]
Receptor-type tyrosine-protein phosphatase zeta (PTPRZ1) OT2NRISU PTPRZ_HUMAN Increases Expression [7]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Decreases Expression [7]
Paired box protein Pax-6 (PAX6) OTOC9876 PAX6_HUMAN Increases Expression [7]
Protein S100-A4 (S100A4) OTLRGFSQ S10A4_HUMAN Decreases Expression [7]
Ciliary neurotrophic factor receptor subunit alpha (CNTFR) OT3B1RGG CNTFR_HUMAN Increases Expression [7]
Stomatin (STOM) OTC8R6EH STOM_HUMAN Decreases Expression [7]
Protein-lysine 6-oxidase (LOX) OT1C2HIU LYOX_HUMAN Decreases Expression [7]
Homeobox protein MSX-1 (MSX1) OT5U41ZP MSX1_HUMAN Decreases Expression [7]
Grancalcin (GCA) OTAJ7ZHG GRAN_HUMAN Decreases Expression [7]
Cellular retinoic acid-binding protein 1 (CRABP1) OTISDG5X RABP1_HUMAN Increases Expression [7]
Aquaporin-1 (AQP1) OTX5MYX9 AQP1_HUMAN Decreases Expression [7]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Decreases Expression [7]
Tyrosine-protein kinase receptor UFO (AXL) OTKA2SUX UFO_HUMAN Decreases Expression [7]
Translocator protein (TSPO) OTSU7ESK TSPO_HUMAN Decreases Expression [7]
Gastrin-releasing peptide receptor (GRPR) OTBQGYJT GRPR_HUMAN Decreases Expression [7]
Homeobox protein Hox-C8 (HOXC8) OTJUYU8J HXC8_HUMAN Decreases Expression [7]
Syndecan-4 (SDC4) OTKUVUGZ SDC4_HUMAN Decreases Expression [7]
Dimethylaniline monooxygenase 4 (FMO4) OT5UYZL7 FMO4_HUMAN Decreases Expression [7]
Gastrin/cholecystokinin type B receptor (CCKBR) OTQSNXOI GASR_HUMAN Decreases Expression [7]
Serpin B6 (SERPINB6) OT7G55IK SPB6_HUMAN Decreases Expression [7]
Apelin receptor (APLNR) OT8585HU APJ_HUMAN Decreases Expression [7]
Copper-transporting ATPase 2 (ATP7B) OTPWLNCO ATP7B_HUMAN Decreases Expression [7]
Collagen alpha-1(XVIII) chain (COL18A1) OTJFUH6O COIA1_HUMAN Decreases Expression [7]
Melanocyte protein PMEL (PMEL) OTCDDHHM PMEL_HUMAN Increases Expression [7]
Peripherin (PRPH) OT6VUH78 PERI_HUMAN Decreases Expression [7]
Transcription factor SOX-3 (SOX3) OT1CRCOB SOX3_HUMAN Increases Expression [7]
Glutamate receptor 2 (GRIA2) OT5N1WB7 GRIA2_HUMAN Increases Expression [7]
Troponin T, cardiac muscle (TNNT2) OT80NN7R TNNT2_HUMAN Decreases Expression [7]
Peptidyl-prolyl cis-trans isomerase C (PPIC) OTY5Q42N PPIC_HUMAN Decreases Expression [7]
Leptin receptor (LEPR) OT9H7G0C LEPR_HUMAN Decreases Expression [7]
Neuromedin-U (NMU) OTW9X7BQ NMU_HUMAN Increases Expression [7]
Nestin (NES) OTZ9PZ14 NEST_HUMAN Increases Expression [7]
Casein kinase I isoform delta (CSNK1D) OTNF4S77 KC1D_HUMAN Decreases Expression [7]
CCAAT/enhancer-binding protein delta (CEBPD) OTNBIPMY CEBPD_HUMAN Decreases Expression [7]
Regulator of G-protein signaling 4 (RGS4) OTG94HHL RGS4_HUMAN Decreases Expression [7]
Cyclin-dependent kinase inhibitor 1C (CDKN1C) OTASTJ3Q CDN1C_HUMAN Decreases Expression [7]
Serpin B9 (SERPINB9) OTJ811IF SPB9_HUMAN Decreases Expression [7]
Serpin H1 (SERPINH1) OTKGI7BS SERPH_HUMAN Decreases Expression [7]
Ras association domain-containing protein 2 (RASSF2) OT2JHDO4 RASF2_HUMAN Increases Expression [7]
Lipopolysaccharide-responsive and beige-like anchor protein (LRBA) OTOUZN9G LRBA_HUMAN Decreases Expression [7]
RNA-binding protein Nova-1 (NOVA1) OT6A9KHY NOVA1_HUMAN Increases Expression [7]
Neuronal membrane glycoprotein M6-a (GPM6A) OT8G13EG GPM6A_HUMAN Increases Expression [7]
Lumican (LUM) OTSRC874 LUM_HUMAN Decreases Expression [7]
Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) OT4O4NFS ROA3_HUMAN Decreases Expression [7]
Rho GDP-dissociation inhibitor 2 (ARHGDIB) OT9PD6CS GDIR2_HUMAN Decreases Expression [7]
Cationic amino acid transporter 2 (SLC7A2) OTAMWBVM CTR2_HUMAN Decreases Expression [7]
Atrophin-1 (ATN1) OTNZFLKY ATN1_HUMAN Increases Expression [7]
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (PDE1A) OTU7J3F7 PDE1A_HUMAN Increases Expression [7]
Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMGCS2) OTC3RUN9 HMCS2_HUMAN Decreases Expression [7]
Phospholipid transfer protein (PLTP) OTVJJO5Z PLTP_HUMAN Decreases Expression [7]
Microfibril-associated glycoprotein 4 (MFAP4) OT5W64QY MFAP4_HUMAN Decreases Expression [7]
Cadherin-11 (CDH11) OTIZKPTF CAD11_HUMAN Decreases Expression [7]
Claudin-15 (CLDN15) OT9K0KI7 CLD15_HUMAN Decreases Expression [7]
Junctional adhesion molecule B (JAM2) OTHVJJRJ JAM2_HUMAN Increases Expression [7]
Myelin proteolipid protein (PLP1) OT8CM9CX MYPR_HUMAN Increases Expression [7]
Protein S100-A10 (S100A10) OTI71243 S10AA_HUMAN Decreases Expression [7]
Heart- and neural crest derivatives-expressed protein 2 (HAND2) OTCXYW4Y HAND2_HUMAN Decreases Expression [7]
Neurocalcin-delta (NCALD) OTJZ8UEL NCALD_HUMAN Increases Expression [7]
cAMP-dependent protein kinase inhibitor alpha (PKIA) OT8M5GVO IPKA_HUMAN Decreases Expression [7]
Actin, alpha cardiac muscle 1 (ACTC1) OTJU04B1 ACTC_HUMAN Decreases Expression [7]
Actin, alpha skeletal muscle (ACTA1) OTOVGLPG ACTS_HUMAN Increases Expression [7]
Pituitary homeobox 1 (PITX1) OTA0UN4C PITX1_HUMAN Decreases Expression [7]
Oxidized low-density lipoprotein receptor 1 (OLR1) OTS44RIC OLR1_HUMAN Decreases Expression [7]
Iroquois-class homeodomain protein IRX-5 (IRX5) OT05J514 IRX5_HUMAN Increases Expression [7]
Reelin (RELN) OTLKMW1O RELN_HUMAN Decreases Expression [7]
Arginase-2, mitochondrial (ARG2) OTCPI0E8 ARGI2_HUMAN Decreases Expression [7]
Metallothionein-1X (MT1X) OT9AKFVS MT1X_HUMAN Decreases Expression [7]
Matrix-remodeling-associated protein 7 (MXRA7) OTVQLYIY MXRA7_HUMAN Decreases Expression [7]
Disabled homolog 2 (DAB2) OTRMQTMZ DAB2_HUMAN Decreases Expression [7]
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (PDE1B) OT9NPJCR PDE1B_HUMAN Increases Expression [7]
Myosin regulatory light chain 2, atrial isoform (MYL7) OT7ZNDP4 MLRA_HUMAN Decreases Expression [7]
Peripheral myelin protein 22 (PMP22) OTXWYWCZ PMP22_HUMAN Decreases Expression [7]
Flavin-containing monooxygenase 1 (FMO1) OTTHSQKP FMO1_HUMAN Decreases Expression [7]
ATP-dependent 6-phosphofructokinase, platelet type (PFKP) OTFP7AA8 PFKAP_HUMAN Decreases Expression [7]
Zinc finger protein basonuclin-1 (BNC1) OTGJ5WUF BNC1_HUMAN Decreases Expression [7]
Transgelin (TAGLN) OTAEZ0KP TAGL_HUMAN Increases Expression [7]
Guanylate cyclase soluble subunit alpha-1 (GUCY1A1) OTPTCBUN GCYA1_HUMAN Decreases Expression [7]
Sterol 26-hydroxylase, mitochondrial (CYP27A1) OT649C01 CP27A_HUMAN Decreases Expression [7]
Desmocollin-2 (DSC2) OTODVH8K DSC2_HUMAN Decreases Expression [7]
Angiopoietin-1 receptor (TEK) OT78YN57 TIE2_HUMAN Decreases Expression [7]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1) OT3ZIANF PLOD1_HUMAN Decreases Expression [7]
Transforming growth factor beta receptor type 3 (TGFBR3) OTQOOUC4 TGBR3_HUMAN Decreases Expression [7]
Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R) OTQF5ZAK PTH1R_HUMAN Decreases Expression [7]
MBT domain-containing protein 1 (MBTD1) OT2P6943 MBTD1_HUMAN Increases Expression [7]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B) OTOA8WU2 PDE4B_HUMAN Increases Expression [7]
Trefoil factor 3 (TFF3) OTJJDRTU TFF3_HUMAN Increases Expression [7]
Regulator of G-protein signaling 1 (RGS1) OTGXJYMG RGS1_HUMAN Decreases Expression [7]
Neuroblast differentiation-associated protein AHNAK (AHNAK) OT6KH1WG AHNK_HUMAN Decreases Expression [7]
Coiled-coil domain-containing protein 15 (CCDC15) OT1NZX84 CCD15_HUMAN Increases Expression [7]
Transmembrane protein 62 (TMEM62) OTJ4SPCM TMM62_HUMAN Increases Expression [7]
Bone marrow stromal antigen 2 (BST2) OTU4LCJV BST2_HUMAN Decreases Expression [7]
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3GAL1) OTFCO8QX SIA4A_HUMAN Decreases Expression [7]
Tyrosine-protein kinase Mer (MERTK) OTWBRAJ6 MERTK_HUMAN Decreases Expression [7]
Transmembrane emp24 domain-containing protein 1 (TMED1) OTWSH0J8 TMED1_HUMAN Decreases Expression [7]
Filamin-C (FLNC) OT3F8J6Y FLNC_HUMAN Decreases Expression [7]
Transforming growth factor beta activator LRRC32 (LRRC32) OTG7EDZL LRC32_HUMAN Decreases Expression [7]
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (PIGH) OTMCFF0K PIGH_HUMAN Decreases Expression [7]
Desmocollin-3 (DSC3) OTYG47F8 DSC3_HUMAN Decreases Expression [7]
Eukaryotic translation initiation factor 4H (EIF4H) OTGZI072 IF4H_HUMAN Decreases Expression [7]
Periostin (POSTN) OTWP62UA POSTN_HUMAN Decreases Expression [7]
Phosphoglucomutase-like protein 5 (PGM5) OTEAS7OC PGM5_HUMAN Decreases Expression [7]
Nicotinate-nucleotide pyrophosphorylase (QPRT) OT6SKKLL NADC_HUMAN Decreases Expression [7]
Leucine-rich repeat-containing protein 41 (LRRC41) OT4YSBV5 LRC41_HUMAN Decreases Expression [7]
Delta(24)-sterol reductase (DHCR24) OTP301JW DHC24_HUMAN Decreases Expression [7]
Probable G-protein coupled receptor 19 (GPR19) OTR7MUS5 GPR19_HUMAN Increases Expression [7]
Alpha-internexin (INA) OT1D33T4 AINX_HUMAN Increases Expression [7]
Kynureninase (KYNU) OTINL2RE KYNU_HUMAN Decreases Expression [7]
Thiosulfate sulfurtransferase (TST) OTZ4F5LK THTR_HUMAN Decreases Expression [7]
Reticulon-1 (RTN1) OTCX1SMK RTN1_HUMAN Increases Expression [7]
Discoidin domain-containing receptor 2 (DDR2) OT9IHOGZ DDR2_HUMAN Decreases Expression [7]
Rho GTPase-activating protein 44 (ARHGAP44) OTHJUCO1 RHG44_HUMAN Decreases Expression [7]
Sodium-coupled monocarboxylate transporter 2 (SLC5A12) OTKY9NAL SC5AC_HUMAN Decreases Expression [7]
Keratin, type I cytoskeletal 24 (KRT24) OTR7MT1E K1C24_HUMAN Decreases Expression [7]
Electroneutral sodium bicarbonate exchanger 1 (SLC4A8) OTKJ0X6Q S4A8_HUMAN Decreases Expression [7]
HLA class II histocompatibility antigen, DR beta 5 chain (HLA-DRB5) OTUX5TWM DRB5_HUMAN Decreases Expression [7]
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4 (MINDY4) OTBZ2SZB MINY4_HUMAN Decreases Expression [7]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (PLCH1) OT6Z1L2E PLCH1_HUMAN Increases Expression [7]
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1) OTOBICRD SVEP1_HUMAN Decreases Expression [7]
PDZ and LIM domain protein 3 (PDLIM3) OTVXQC81 PDLI3_HUMAN Increases Expression [7]
Protein LBH (LBH) OT87AT1X LBH_HUMAN Decreases Expression [7]
Cordon-bleu protein-like 1 (COBLL1) OTQFN1TC COBL1_HUMAN Decreases Expression [7]
Spindlin-4 (SPIN4) OT09ZWHM SPIN4_HUMAN Decreases Expression [7]
Trans-2,3-enoyl-CoA reductase-like (TECRL) OTXLSNCP TECRL_HUMAN Decreases Expression [7]
Placenta-specific protein 9 (PLAC9) OTZHIJ44 PLAC9_HUMAN Decreases Expression [7]
Collectin-12 (COLEC12) OTIQTK9G COL12_HUMAN Decreases Expression [7]
CUGBP Elav-like family member 3 (CELF3) OTTP45WK CELF3_HUMAN Increases Expression [7]
KN motif and ankyrin repeat domain-containing protein 4 (KANK4) OT5WC0Q8 KANK4_HUMAN Decreases Expression [7]
Transcription factor HES-5 (HES5) OTW7JEHV HES5_HUMAN Increases Expression [7]
Collagen alpha-1(XIII) chain (COL13A1) OTM9IM6J CODA1_HUMAN Decreases Expression [7]
Terminal nucleotidyltransferase 5C (TENT5C) OTOWVQ4O TET5C_HUMAN Decreases Expression [7]
FYN-binding protein 2 (FYB2) OTA3NG8M FYB2_HUMAN Decreases Expression [7]
F-actin-uncapping protein LRRC16A (CARMIL1) OT1A5IX5 CARL1_HUMAN Decreases Expression [7]
Pikachurin (EGFLAM) OTACZZJ0 EGFLA_HUMAN Decreases Expression [7]
Carboxypeptidase Z (CPZ) OT5HUR28 CBPZ_HUMAN Decreases Expression [7]
NADH-cytochrome b5 reductase 2 (CYB5R2) OTTLM7XN NB5R2_HUMAN Decreases Expression [7]
Repulsive guidance molecule B (RGMB) OT2DROYU RGMB_HUMAN Increases Expression [7]
Caveolae-associated protein 1 (CAVIN1) OTFO915U CAVN1_HUMAN Decreases Expression [7]
Cdc42 effector protein 5 (CDC42EP5) OTQQDUCD BORG3_HUMAN Decreases Expression [7]
Cytochrome b5 domain-containing protein 1 (CYB5D1) OTSZWTPT CB5D1_HUMAN Decreases Expression [7]
Transmembrane protein 88 (TMEM88) OTA96YEL TMM88_HUMAN Decreases Expression [7]
Protein cornichon homolog 2 (CNIH2) OTT2ECCW CNIH2_HUMAN Increases Expression [7]
Prostate androgen-regulated mucin-like protein 1 (PARM1) OTDNK7EX PARM1_HUMAN Decreases Expression [7]
Inactive serine protease PAMR1 (PAMR1) OT83ZH5U PAMR1_HUMAN Decreases Expression [7]
R-spondin-2 (RSPO2) OT3HHXU0 RSPO2_HUMAN Decreases Expression [7]
Zinc finger protein basonuclin-2 (BNC2) OTU22H9Z BNC2_HUMAN Decreases Expression [7]
Staphylococcal nuclease domain-containing protein 1 (SND1) OTT734JN SND1_HUMAN Decreases Expression [7]
Monocarboxylate transporter 9 (SLC16A9) OTVCLKQQ MOT9_HUMAN Increases Expression [7]
Centriolin (CNTRL) OTQI3VBA CNTRL_HUMAN Increases Expression [7]
Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1) OTKCR5XL CK2N1_HUMAN Increases Expression [7]
Schlafen family member 11 (SLFN11) OTJWFPMY SLN11_HUMAN Increases Expression [7]
Polypeptide N-acetylgalactosaminyltransferase 10 (GALNT10) OTZ6FDOL GLT10_HUMAN Decreases Expression [7]
Alpha-protein kinase 2 (ALPK2) OTWZZDQ9 ALPK2_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase MARCHF3 (MARCHF3) OT89V4N5 MARH3_HUMAN Decreases Expression [7]
Transmembrane protein 200A (TMEM200A) OTVJZIOR T200A_HUMAN Decreases Expression [7]
Podoplanin (PDPN) OTBUV19I PDPN_HUMAN Decreases Expression [7]
Rhophilin-2 (RHPN2) OTTYWMF6 RHPN2_HUMAN Decreases Expression [7]
Epidermal growth factor-like protein 6 (EGFL6) OT331X59 EGFL6_HUMAN Decreases Expression [7]
5'-3' exonuclease PLD3 (PLD3) OTL07SP2 PLD3_HUMAN Decreases Expression [7]
Neuron navigator 2 (NAV2) OTGAOL01 NAV2_HUMAN Decreases Expression [7]
Somatomedin-B and thrombospondin type-1 domain-containing protein (SBSPON) OTBHAW5K SBSPO_HUMAN Decreases Expression [7]
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2) OTRUIMC4 GNT2A_HUMAN Decreases Expression [7]
Sperm-associated antigen 16 protein (SPAG16) OTIFUPYD SPG16_HUMAN Increases Expression [7]
Cytochrome P450 4X1 (CYP4X1) OTMTEUNE CP4X1_HUMAN Decreases Expression [7]
Inactive serine protease 35 (PRSS35) OT09H6WH PRS35_HUMAN Decreases Expression [7]
Secreted frizzled-related protein 1 (SFRP1) OT0U9G41 SFRP1_HUMAN Increases Expression [7]
Reprimo-like protein (RPRML) OTPOESFN RPRML_HUMAN Increases Expression [7]
Actin filament-associated protein 1-like 2 (AFAP1L2) OTJBI0VN AF1L2_HUMAN Decreases Expression [7]
Protocadherin-20 (PCDH20) OTFSNRXK PCD20_HUMAN Decreases Expression [7]
Fibrous sheath-interacting protein 1 (FSIP1) OTYLL6GM FSIP1_HUMAN Increases Expression [7]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (ST6GALNAC3) OTLAQ14Q SIA7C_HUMAN Decreases Expression [7]
Trinucleotide repeat-containing gene 6A protein (TNRC6A) OT493IOM TNR6A_HUMAN Increases Expression [7]
Coiled-coil domain-containing protein 112 (CCDC112) OT3OEYG6 CC112_HUMAN Increases Expression [7]
Class E basic helix-loop-helix protein 22 (BHLHE22) OTZUQY5L BHE22_HUMAN Increases Expression [7]
Secretory carrier-associated membrane protein 5 (SCAMP5) OT9MXA2J SCAM5_HUMAN Increases Expression [7]
Protein odd-skipped-related 1 (OSR1) OTB19LEQ OSR1_HUMAN Decreases Expression [7]
DEP domain-containing mTOR-interacting protein (DEPTOR) OTCBP1BT DPTOR_HUMAN Decreases Expression [7]
Protein MGARP (MGARP) OTL90XO8 HUMMR_HUMAN Decreases Expression [7]
Mucolipin-3 (MCOLN3) OTCRPRVS MCLN3_HUMAN Decreases Expression [7]
Breast carcinoma-amplified sequence 4 (BCAS4) OT596N5E BCAS4_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase SH3RF2 (SH3RF2) OT2IVOK4 SH3R2_HUMAN Decreases Expression [7]
Docking protein 4 (DOK4) OTUEWLG8 DOK4_HUMAN Decreases Expression [7]
Probable phospholipid-transporting ATPase IM (ATP8B4) OT48TSYO AT8B4_HUMAN Decreases Expression [7]
Cell migration-inducing and hyaluronan-binding protein (CEMIP) OTK80FYN CEMIP_HUMAN Decreases Expression [7]
Leucine-rich repeat neuronal protein 4 (LRRN4) OTC2T1MP LRRN4_HUMAN Decreases Expression [7]
Selenoprotein M (SELENOM) OTJ7PORS SELM_HUMAN Decreases Expression [7]
Atlastin-1 (ATL1) OTR2788Y ATLA1_HUMAN Increases Expression [7]
E3 ubiquitin-protein ligase MYLIP (MYLIP) OTL0PFGV MYLIP_HUMAN Decreases Expression [7]
Cyclic GMP-AMP phosphodiesterase SMPDL3A (SMPDL3A) OTQDYH8E ASM3A_HUMAN Decreases Expression [7]
SEC14-like protein 1 (SEC14L1) OTA75FET S14L1_HUMAN Decreases Expression [7]
Protein NDRG1 (NDRG1) OTVO66BO NDRG1_HUMAN Decreases Expression [7]
Ankyrin repeat and SAM domain-containing protein 1A (ANKS1A) OTYZP3MP ANS1A_HUMAN Decreases Expression [7]
Serine protease HTRA1 (HTRA1) OTR8ACBF HTRA1_HUMAN Decreases Expression [7]
Secreted frizzled-related protein 3 (FRZB) OTTO3DPY SFRP3_HUMAN Decreases Expression [7]
Hyaluronan synthase 2 (HAS2) OTTD3PAL HYAS2_HUMAN Decreases Expression [7]
Proprotein convertase subtilisin/kexin type 5 (PCSK5) OTP0RJ4Y PCSK5_HUMAN Decreases Expression [7]
Kallikrein-6 (KLK6) OTIEA234 KLK6_HUMAN Decreases Expression [7]
Exostosin-2 (EXT2) OT8IR5QN EXT2_HUMAN Decreases Expression [7]
Ecto-ADP-ribosyltransferase 4 (ART4) OTTV2J54 NAR4_HUMAN Decreases Expression [7]
Caveolae-associated protein 3 (CAVIN3) OTOLBK79 CAVN3_HUMAN Decreases Expression [7]
Myeloid-derived growth factor (MYDGF) OT9HRPL6 MYDGF_HUMAN Decreases Expression [7]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (ST6GALNAC6) OT3C3VWX SIA7F_HUMAN Decreases Expression [7]
Coiled-coil domain-containing protein 102A (CCDC102A) OTT7XHIP C102A_HUMAN Decreases Expression [7]
Ras-related and estrogen-regulated growth inhibitor (RERG) OTF6MMLV RERG_HUMAN Decreases Expression [7]
Ras-related protein Rab-37 (RAB37) OTRL8IUO RAB37_HUMAN Decreases Expression [7]
Store-operated calcium entry-associated regulatory factor (SARAF) OTH5JIFE SARAF_HUMAN Decreases Expression [7]
BTB/POZ domain-containing protein KCTD12 (KCTD12) OTPYKT4Z KCD12_HUMAN Decreases Expression [7]
Multivesicular body subunit 12A (MVB12A) OT3737K0 MB12A_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase pellino homolog 1 (PELI1) OTMLBCLC PELI1_HUMAN Increases Expression [7]
Phytanoyl-CoA hydroxylase-interacting protein-like (PHYHIPL) OT9EIUGH PHIPL_HUMAN Increases Expression [7]
Multidrug and toxin extrusion protein 1 (SLC47A1) OTZX0U5Q S47A1_HUMAN Decreases Expression [7]
Vacuolar-sorting protein SNF8 (SNF8) OTRQA2AI SNF8_HUMAN Decreases Expression [7]
Secreted frizzled-related protein 2 (SFRP2) OT8GZ0CA SFRP2_HUMAN Increases Expression [7]
PC-esterase domain-containing protein 1B (PCED1B) OT19CDAB PED1B_HUMAN Decreases Expression [7]
Terminal nucleotidyltransferase 5A (TENT5A) OTSYF511 TET5A_HUMAN Decreases Expression [7]
Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) OTY5HZN5 LRIG1_HUMAN Increases Expression [7]
Lysyl oxidase homolog 4 (LOXL4) OT6XY2JL LOXL4_HUMAN Decreases Expression [7]
Multiple epidermal growth factor-like domains protein 10 (MEGF10) OTILSPJ6 MEG10_HUMAN Increases Expression [7]
N-terminal kinase-like protein (SCYL1) OTQ0IN7P SCYL1_HUMAN Decreases Expression [7]
Ecto-ADP-ribosyltransferase 5 (ART5) OTEZUT8V NAR5_HUMAN Decreases Expression [7]
Protein phosphatase 1M (PPM1M) OTCPLZQ7 PPM1M_HUMAN Decreases Expression [7]
Roundabout homolog 3 (ROBO3) OTPVG40S ROBO3_HUMAN Increases Expression [7]
Prickle-like protein 1 (PRICKLE1) OT9HHEM9 PRIC1_HUMAN Decreases Expression [7]
Leucine-rich repeat and fibronectin type-III domain-containing protein 5 (LRFN5) OTK7QZ3B LRFN5_HUMAN Decreases Expression [7]
Guanylate-binding protein 4 (GBP4) OTSPNGKX GBP4_HUMAN Decreases Expression [7]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1) OTMV4ASV MAGI1_HUMAN Increases Expression [7]
Myeloid-associated differentiation marker (MYADM) OTZTZI7P MYADM_HUMAN Decreases Expression [7]
Protein Niban 2 (NIBAN2) OTVDQSPI NIBA2_HUMAN Decreases Expression [7]
Transcription factor 12 (TCF12) OTZVONNU HTF4_HUMAN Increases Expression [7]
Protein kinase C-binding protein NELL2 (NELL2) OTS4MJZ7 NELL2_HUMAN Increases Expression [7]
G-protein coupled estrogen receptor 1 (GPER1) OTUK0TDC GPER1_HUMAN Decreases Expression [7]
Pituitary homeobox 2 (PITX2) OTWMXAOY PITX2_HUMAN Decreases Expression [7]
Plakophilin-2 (PKP2) OTJOVF68 PKP2_HUMAN Decreases Expression [7]
Cbp/p300-interacting transactivator 2 (CITED2) OT812TV7 CITE2_HUMAN Decreases Expression [7]
Ribosome quality control complex subunit TCF25 (TCF25) OTTFHHU9 TCF25_HUMAN Decreases Expression [7]
Allograft inflammatory factor 1-like (AIF1L) OTDEOB80 AIF1L_HUMAN Increases Expression [7]
SH3-containing GRB2-like protein 3-interacting protein 1 (SGIP1) OTQW6R3Z SGIP1_HUMAN Increases Expression [7]
Transcription elongation factor A protein-like 7 (TCEAL7) OTNPDZCN TCAL7_HUMAN Increases Expression [7]
Histone H2A.J (H2AJ) OTVA4XTW H2AJ_HUMAN Decreases Expression [7]
Ribonuclease P protein subunit p25 (RPP25) OTEN6QN7 RPP25_HUMAN Decreases Expression [7]
EF-hand domain-containing protein D1 (EFHD1) OTL5INE4 EFHD1_HUMAN Decreases Expression [7]
Arginine/serine-rich protein 1 (RSRP1) OTOAZLCL RSRP1_HUMAN Decreases Expression [7]
Transmembrane emp24 domain-containing protein 9 (TMED9) OTYGAQS0 TMED9_HUMAN Decreases Expression [7]
Max dimerization protein 3 (MXD3) OT4U88UP MAD3_HUMAN Increases Expression [7]
Transcription factor GATA-5 (GATA5) OTO81B63 GATA5_HUMAN Decreases Expression [7]
Oxysterol-binding protein-related protein 10 (OSBPL10) OT0TFMBE OSB10_HUMAN Decreases Expression [7]
Uncharacterized protein KIAA1671 (KIAA1671) OTYGNSCG K1671_HUMAN Decreases Expression [7]
Tripartite motif-containing protein 6 (TRIM6) OTBSMX0B TRIM6_HUMAN Decreases Expression [7]
Tripartite motif-containing protein 5 (TRIM5) OTMZH7EJ TRIM5_HUMAN Decreases Expression [7]
RNA exonuclease 4 (REXO4) OT2NNFKZ REXO4_HUMAN Decreases Expression [7]
Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19) OTH88TXU ADA19_HUMAN Decreases Expression [7]
Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) OTVSFHTL CRLD2_HUMAN Decreases Expression [7]
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) OT4U7SBG GBRL1_HUMAN Decreases Expression [7]
Small conductance calcium-activated potassium channel protein 2 (KCNN2) OTQVTMK5 KCNN2_HUMAN Decreases Expression [7]
Thiamin pyrophosphokinase 1 (TPK1) OTCHPUD0 TPK1_HUMAN Decreases Expression [7]
SPARC-related modular calcium-binding protein 2 (SMOC2) OTK1EQ49 SMOC2_HUMAN Decreases Expression [7]
Leucine-rich repeat neuronal protein 3 (LRRN3) OT7X0AA7 LRRN3_HUMAN Increases Expression [7]
RWD domain-containing protein 1 (RWDD1) OTVEZWQG RWDD1_HUMAN Increases Expression [7]
Calcium-binding protein 39-like (CAB39L) OTQEBL0W CB39L_HUMAN Decreases Expression [7]
Spondin-1 (SPON1) OTC06MY4 SPON1_HUMAN Decreases Expression [7]
Anoctamin-8 (ANO8) OT07SRRX ANO8_HUMAN Increases Expression [7]
Synaptotagmin-like protein 2 (SYTL2) OTUIOWKL SYTL2_HUMAN Increases Expression [7]
Solute carrier family 40 member 1 (SLC40A1) OT8RV2VY S40A1_HUMAN Decreases Expression [7]
Zinc transporter ZIP2 (SLC39A2) OTE0GI4W S39A2_HUMAN Decreases Expression [7]
NADPH oxidase 4 (NOX4) OTTYQ097 NOX4_HUMAN Decreases Expression [7]
Nuclear receptor-interacting protein 3 (NRIP3) OTU15GMK NRIP3_HUMAN Decreases Expression [7]
G-protein coupled receptor family C group 5 member C (GPRC5C) OT45AJT3 GPC5C_HUMAN Decreases Expression [7]
PR domain zinc finger protein 8 (PRDM8) OTRA3265 PRDM8_HUMAN Increases Expression [7]
Integral membrane protein 2C (ITM2C) OTHVMXE3 ITM2C_HUMAN Decreases Expression [7]
Rho guanine nucleotide exchange factor 3 (ARHGEF3) OTHGNC0A ARHG3_HUMAN Decreases Expression [7]
Olfactomedin-like protein 3 (OLFML3) OTDN45FN OLFL3_HUMAN Decreases Expression [7]
Kinesin-like protein KIF15 (KIF15) OTJRJEXL KIF15_HUMAN Increases Expression [7]
Serine palmitoyltransferase 3 (SPTLC3) OTZDX6PT SPTC3_HUMAN Decreases Expression [7]
Transmembrane protein 45A (TMEM45A) OT54KJG6 TM45A_HUMAN Decreases Expression [7]
Host cell factor C1 regulator 1 (HCFC1R1) OTGDPS5C HPIP_HUMAN Decreases Expression [7]
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2) OT65C86U IMPA3_HUMAN Decreases Expression [7]
PH and SEC7 domain-containing protein 3 (PSD3) OTTN9B9O PSD3_HUMAN Increases Expression [7]
G-protein coupled receptor 83 (GPR83) OT7A2FE8 GPR83_HUMAN Decreases Expression [7]
Podocalyxin-like protein 2 (PODXL2) OTB3PUR8 PDXL2_HUMAN Increases Expression [7]
Ral guanine nucleotide dissociation stimulator-like 1 (RGL1) OTY6ZHVA RGL1_HUMAN Decreases Expression [7]
Myoferlin (MYOF) OTRFC3IJ MYOF_HUMAN Decreases Expression [7]
Low-density lipoprotein receptor-related protein 1B (LRP1B) OT4YZG2N LRP1B_HUMAN Decreases Expression [7]
LIM and cysteine-rich domains protein 1 (LMCD1) OT3AWE8O LMCD1_HUMAN Decreases Expression [7]
Protein PALS2 (PALS2) OTV12NKE PALS2_HUMAN Decreases Expression [7]
Spermatogenesis-associated protein 7 (SPATA7) OT78G2IH SPAT7_HUMAN Increases Expression [7]
Neurotrimin (NTM) OTHF0UQU NTRI_HUMAN Decreases Expression [7]
C-type lectin domain family 1 member B (CLEC1B) OTO38TRG CLC1B_HUMAN Decreases Expression [7]
Dynein axonemal heavy chain 2 (DNAH2) OT7J5LDI DYH2_HUMAN Decreases Expression [7]
Semaphorin-5B (SEMA5B) OTUVSKK0 SEM5B_HUMAN Increases Expression [7]
Signal-induced proliferation-associated 1-like protein 2 (SIPA1L2) OT8NJE5D SI1L2_HUMAN Decreases Expression [7]
Protein dispatched homolog 3 (DISP3) OTEW6RYT DISP3_HUMAN Increases Expression [7]
A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) OTV3Q0DS ATS9_HUMAN Decreases Expression [7]
Vesicular glutamate transporter 2 (SLC17A6) OTP1MJGP VGLU2_HUMAN Increases Expression [7]
Beta-1,4-galactosyltransferase 7 (B4GALT7) OTG5WHRW B4GT7_HUMAN Decreases Expression [7]
Tachykinin-3 (TAC3) OTOJGM38 TKNK_HUMAN Decreases Expression [7]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) OTTLJH8W ATS1_HUMAN Decreases Expression [7]
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAIAP2L1) OTZ71SK9 BI2L1_HUMAN Decreases Expression [7]
SERTA domain-containing protein 1 (SERTAD1) OTBHKZQP SRTD1_HUMAN Decreases Expression [7]
F-box only protein 2 (FBXO2) OTF3677S FBX2_HUMAN Decreases Expression [7]
Angiopoietin-related protein 2 (ANGPTL2) OTB6JG41 ANGL2_HUMAN Decreases Expression [7]
Microtubule-associated tumor suppressor 1 (MTUS1) OTBPALMU MTUS1_HUMAN Increases Expression [7]
Y+L amino acid transporter 1 (SLC7A7) OTYNABBR YLAT1_HUMAN Decreases Expression [7]
Lysosomal thioesterase PPT2 (PPT2) OTD5VJ9A PPT2_HUMAN Decreases Expression [7]
Protein NDRG2 (NDRG2) OT5L6KD7 NDRG2_HUMAN Decreases Expression [7]
LIM and calponin homology domains-containing protein 1 (LIMCH1) OTYPC4XA LIMC1_HUMAN Increases Expression [7]
Type 2 lactosamine alpha-2,3-sialyltransferase (ST3GAL6) OTB17Q43 SIA10_HUMAN Decreases Expression [7]
Nuclease EXOG, mitochondrial (EXOG) OTZAI8L7 EXOG_HUMAN Decreases Expression [7]
Netrin-G1 (NTNG1) OTF48IID NTNG1_HUMAN Increases Expression [7]
Protein SSUH2 homolog (SSUH2) OTWUBDV0 SSUH2_HUMAN Increases Expression [7]
Transmembrane protein 98 (TMEM98) OTKDUEED TMM98_HUMAN Decreases Expression [7]
Plasmolipin (PLLP) OTFGCB9U PLLP_HUMAN Decreases Expression [7]
C2 domain-containing protein 2 (C2CD2) OTL1K0OB C2CD2_HUMAN Decreases Expression [7]
Talin-2 (TLN2) OT10QQBC TLN2_HUMAN Decreases Expression [7]
Protein mab-21-like 2 (MAB21L2) OTZM5VMX MB212_HUMAN Decreases Expression [7]
Transient receptor potential cation channel subfamily V member 2 (TRPV2) OT0A9AVD TRPV2_HUMAN Decreases Expression [7]
Transcription factor SOX-21 (SOX21) OTNT50CC SOX21_HUMAN Increases Expression [7]
LHFPL tetraspan subfamily member 6 protein (LHFPL6) OTY6LHJY LHPL6_HUMAN Increases Expression [7]
Stonin-1 (STON1) OT2HPUAI STON1_HUMAN Decreases Expression [7]
Transcription factor E2F8 (E2F8) OTQKZGFP E2F8_HUMAN Increases Expression [9]
Thymidine kinase 2, mitochondrial (TK2) OTS1V4XB KITM_HUMAN Decreases Expression [23]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [24]
Protein regulator of cytokinesis 1 (PRC1) OTHD0XS0 PRC1_HUMAN Decreases Expression [8]
PRA1 family protein 3 (ARL6IP5) OTYZ6BEQ PRAF3_HUMAN Increases Expression [25]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Affects Expression [26]
Plasminogen (PLG) OTWWIPPY PLMN_HUMAN Affects Localization [27]
Prolactin (PRL) OTWFQGX7 PRL_HUMAN Increases Expression [28]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Expression [29]
Thymidine kinase, cytosolic (TK1) OTY5JFM1 KITH_HUMAN Decreases Expression [23]
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) OTBPMIMW G3P_HUMAN Decreases Activity [30]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Expression [29]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [31]
High mobility group protein B1 (HMGB1) OT4B7CPF HMGB1_HUMAN Increases Secretion [32]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Degradation [33]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [31]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Phosphorylation [30]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [9]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [9]
Cyclin-dependent kinases regulatory subunit 2 (CKS2) OTPTMHIV CKS2_HUMAN Decreases Expression [8]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [9]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [34]
Importin subunit alpha-1 (KPNA2) OTU7FOE6 IMA1_HUMAN Decreases Expression [8]
Sestrin-3 (SESN3) OTJRY1Y5 SESN3_HUMAN Decreases Expression [9]
Beta-2-microglobulin (B2M) OTDWN6NX B2MG_HUMAN Increases Expression [35]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (PLCB2) OTPAHDGO PLCB2_HUMAN Affects Localization [36]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Activity [37]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [38]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [39]
Cyclin-dependent kinase 5 activator 1 (CDK5R1) OTJELWK0 CD5R1_HUMAN Increases Expression [9]
Borealin (CDCA8) OT17D55D BOREA_HUMAN Decreases Expression [8]
Proline/serine-rich coiled-coil protein 1 (PSRC1) OT7MDJMN PSRC1_HUMAN Decreases Expression [8]
Protein aurora borealis (BORA) OTV2ZPKP BORA_HUMAN Decreases Expression [8]
Jouberin (AHI1) OT8K2YWY AHI1_HUMAN Increases Expression [40]
Transient receptor potential cation channel subfamily V member 1 (TRPV1) OTHHDR03 TRPV1_HUMAN Affects Localization [41]
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) OTTVT4MB TNR19_HUMAN Decreases Expression [9]
Solute carrier family 12 member 6 (SLC12A6) OT9CS413 S12A6_HUMAN Decreases Expression [9]
Lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5) OT27CCUF SIAT9_HUMAN Decreases Expression [9]
Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) OTJQL0I3 HEY1_HUMAN Decreases Expression [9]
Interleukin-3 (IL3) OT0CQ35N IL3_HUMAN Increases ADR [42]
Kynurenine 3-monooxygenase (KMO) OT3MRMM9 KMO_HUMAN Increases Response To Substance [43]
Stathmin-4 (STMN4) OT7ZUKW6 STMN4_HUMAN Increases Response To Substance [43]
Histone-lysine N-methyltransferase 2A (KMT2A) OT9GLJI6 KMT2A_HUMAN Increases Response To Substance [44]
Protein lyl-1 (LYL1) OTCNOV1M LYL1_HUMAN Decreases Response To Substance [45]
Metalloproteinase inhibitor 3 (TIMP3) OTDGQAD1 TIMP3_HUMAN Decreases Response To Substance [46]
Tumor protein p53-inducible protein 11 (TP53I11) OTFPDYZU P5I11_HUMAN Increases Response To Substance [43]
Hepatocyte growth factor (HGF) OTGHUA23 HGF_HUMAN Increases ADR [42]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Affects Response To Substance [47]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Response To Substance [48]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Decreases Response To Substance [49]
Protein kinase C zeta type (PRKCZ) OTN2FE42 KPCZ_HUMAN Decreases Response To Substance [50]
Calcitonin receptor (CALCR) OTOVDJ7S CALCR_HUMAN Increases Response To Substance [43]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Increases Response To Substance [51]
Glutathione S-transferase Mu 1 (GSTM1) OTSBF2MO GSTM1_HUMAN Affects Response To Substance [11]
Methylenetetrahydrofolate reductase (MTHFR) OTUBJSR7 MTHR_HUMAN Affects Response To Substance [46]
Deoxycytidine kinase (DCK) OTW8HLZC DCK_HUMAN Decreases Response To Substance [22]
------------------------------------------------------------------------------------
⏷ Show the Full List of 549 DOT(s)
Indication(s) of Clindamycin
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Approved [4]
Aspiration pneumonia N.A. Approved [5]
Bacteremia 1A73 Approved [5]
Bacterial vaginosis MF3A Approved [5]
Pleural empyema N.A. Approved [5]
Staphylococcal pneumonia N.A. Approved [5]
Staphylococcus aureus infection N.A. Approved [5]
Streptococcal pneumonia N.A. Approved [5]
Pelvic inflammatory disease GA05 Investigative [5]
Clindamycin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Bacterial 50S ribosomal RNA (Bact 50S rRNA) TTUWYEA NOUNIPROTAC Binder [52]
------------------------------------------------------------------------------------
Clindamycin Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [53]
Beta-lactamase (blaB) DEMSNER A4LA84_EDWTA Metabolism [54]
------------------------------------------------------------------------------------
Clindamycin Interacts with 4 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases Expression [55]
HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1) OTRGGIFP DRB1_HUMAN Affects Expression [56]
HLA class I histocompatibility antigen, alpha chain E (HLA-E) OTX1CTFB HLAE_HUMAN Affects Expression [56]
Collagenase 3 (MMP13) OTY8BZIE MMP13_HUMAN Increases Expression [57]
------------------------------------------------------------------------------------

References

1 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4827).
3 Cytarabine FDA Label
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
5 Clindamycin FDA Label
6 The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
7 Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
8 Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling. Mutat Res. 2007 Jun 1;619(1-2):16-29. doi: 10.1016/j.mrfmmm.2006.12.007. Epub 2007 Feb 8.
9 Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
10 Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias. Clin Cancer Res. 2000 May;6(5):1796-803.
11 Pharmacogenetics of outcome in children with acute lymphoblastic leukemia. Blood. 2005 Jun 15;105(12):4752-8. doi: 10.1182/blood-2004-11-4544. Epub 2005 Feb 15.
12 Vascular endothelial growth factor-C modulates proliferation and chemoresistance in acute myeloid leukemic cells through an endothelin-1-dependent induction of cyclooxygenase-2. Biochim Biophys Acta. 2014 Feb;1843(2):387-97. doi: 10.1016/j.bbamcr.2013.10.015. Epub 2013 Oct 31.
13 Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage. Mol Cancer Ther. 2009 Apr;8(4):864-72.
14 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
15 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
16 OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues. Cancer Res. 2017 Apr 15;77(8):2102-2111.
17 FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia. Oncotarget. 2016 Aug 2;7(31):49786-49799.
18 Synthesis and characterization of a novel liver-targeted prodrug of cytosine-1-beta-D-arabinofuranoside monophosphate for the treatment of hepatocellular carcinoma. J Med Chem. 2006 Dec 28;49(26):7711-20.
19 Genetic factors influencing cytarabine therapy. Pharmacogenomics. 2009 Oct;10(10):1657-74.
20 Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs. FEBS Open Bio. 2015 Aug 3;5:634-9.
21 [Relationship between the induction of MDR1, a multidrug resistance gene in tumor cells, and apoptosis]. Ontogenez. 2001 Jul-Aug;32(4):295-301.
22 Two distinct molecular mechanisms underlying cytarabine resistance in human leukemic cells. Cancer Res. 2008 Apr 1;68(7):2349-57. doi: 10.1158/0008-5472.CAN-07-5528.
23 Arabinosylcytosine downregulates thymidine kinase and induces cross-resistance to zidovudine in T-lymphoid cells. Biochem Biophys Res Commun. 2003 Aug 1;307(3):564-8. doi: 10.1016/s0006-291x(03)01232-4.
24 [Combined effect of TNF-related apoptosis induced ligand and Ara-C in inducing apoptosis of HL-60 cells and its mechanism]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Jun;16(3):510-5.
25 JWA, a novel signaling molecule, involved in the induction of differentiation of human myeloid leukemia cells. Biochem Biophys Res Commun. 2006 Mar 10;341(2):440-50. doi: 10.1016/j.bbrc.2005.12.197. Epub 2006 Jan 11.
26 The effects of chemotherapeutic agents on the regulation of thrombin on cell surfaces. Br J Haematol. 2003 Jan;120(2):315-24. doi: 10.1046/j.1365-2141.2003.03971.x.
27 Arsenic trioxide, retinoic acid and Ara-c regulated the expression of annexin II on the surface of APL cells, a novel co-receptor for plasminogen/tissue plasminogen activator. Thromb Res. 2002 Apr 1;106(1):63-70. doi: 10.1016/s0049-3848(02)00075-0.
28 Prolactinemia in adolescent males surviving malignancies in childhood: impaired dating activity. J Adolesc Health. 1993 Nov;14(7):543-7. doi: 10.1016/1054-139x(93)90138-f.
29 Proinflammatory cytokines mediate the systemic inflammatory response associated with high-dose cytarabine treatment in children. Med Pediatr Oncol. 2001 Nov;37(5):459-64. doi: 10.1002/mpo.1230.
30 Glyceraldehyde 3-phosphate dehydrogenase depletion induces cell cycle arrest and resistance to antimetabolites in human carcinoma cell lines. J Pharmacol Exp Ther. 2009 Oct;331(1):77-86. doi: 10.1124/jpet.109.155671. Epub 2009 Jul 23.
31 Granulocyte-macrophage colony-stimulating factor/interleukin-3 fusion protein (pIXY 321) enhances high-dose Ara-C-induced programmed cell death or apoptosis in human myeloid leukemia cells. Blood. 1992 Dec 1;80(11):2883-90.
32 [Influence of HMGB1/MAPK/m-TOR signaling pathway on cell autophagy and chemotherapy resistance in K562 cells]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2016 Oct 28;41(10):1016-1023. doi: 10.11817/j.issn.1672-7347.2016.10.002.
33 Overexpression of Bcl-2 or Bcl-xL inhibits Ara-C-induced CPP32/Yama protease activity and apoptosis of human acute myelogenous leukemia HL-60 cells. Cancer Res. 1996 Oct 15;56(20):4743-8.
34 Ara-C induces apoptosis in monkey fibroblast cells. Toxicol In Vitro. 2003 Jun;17(3):367-73. doi: 10.1016/s0887-2333(03)00024-9.
35 Cytosine arabinoside induced acute interstitial nephritis in a patient treated for refractory anemia with excess of blasts in transformation. Nephron. 2000 Nov;86(3):356-7. doi: 10.1159/000045798.
36 Protein kinase CbetaII activation by 1-beta-D-arabinofuranosylcytosine is antagonistic to stimulation of apoptosis and Bcl-2alpha down-regulation. J Biol Chem. 1997 Sep 19;272(38):23481-4. doi: 10.1074/jbc.272.38.23481.
37 Mechanism of cytosine arabinoside-mediated apoptosis: role of Rel A (p65) dephosphorylation. Oncogene. 2003 Jul 10;22(28):4356-69. doi: 10.1038/sj.onc.1206486.
38 Differential p53 phosphorylation and activation of apoptosis-promoting genes Bax and Fas/APO-1 by irradiation and ara-C treatment. Cell Death Differ. 1998 Jul;5(7):584-91. doi: 10.1038/sj.cdd.4400382.
39 The mechanisms of Ara-C-induced apoptosis of resting B-chronic lymphocytic leukemia cells. Haematologica. 2006 Jul;91(7):912-9.
40 [Expression and function of Ahi-1 gene in Jurkat cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Apr;17(2):445-9.
41 Cytosine arabinoside affects the heat and capsaicin receptor TRPV1 localisation and sensitivity in human sensory neurons. J Neurooncol. 2008 Aug;89(1):1-7. doi: 10.1007/s11060-008-9585-6. Epub 2008 Apr 15.
42 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
43 Genome-wide local ancestry approach identifies genes and variants associated with chemotherapeutic susceptibility in African Americans. PLoS One. 2011;6(7):e21920. doi: 10.1371/journal.pone.0021920. Epub 2011 Jul 6.
44 In vitro drug-resistance profile in infant acute lymphoblastic leukemia in relation to age, MLL rearrangements and immunophenotype. Leukemia. 2004 Mar;18(3):521-9. doi: 10.1038/sj.leu.2403253.
45 Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia. Leukemia. 2005 Nov;19(11):1941-7. doi: 10.1038/sj.leu.2403836.
46 DNA methylation and sensitivity to antimetabolites in cancer cell lines. Oncol Rep. 2008 Feb;19(2):407-12.
47 Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance. Hematology. 2007 Dec;12(6):511-7. doi: 10.1080/10245330701562535.
48 Chromosome breakage induced by the genotoxic agents mitomycin C and cytosine arabinoside is concentration and p53 dependent. Toxicol Sci. 2014 Jul;140(1):94-102. doi: 10.1093/toxsci/kfu058. Epub 2014 Mar 27.
49 Reversible epigenetic regulation of 14-3-3 expression in acquired gemcitabine resistance by uhrf1 and DNA methyltransferase 1. Mol Pharmacol. 2014 Nov;86(5):561-9. doi: 10.1124/mol.114.092544. Epub 2014 Sep 4.
50 4-benzimidazolyl-3-phenylbutanoic acids as novel PIF-pocket-targeting allosteric inhibitors of protein kinase PKC. J Med Chem. 2011 Oct 13;54(19):6714-23. doi: 10.1021/jm2005892. Epub 2011 Sep 14.
51 Effect of phosphatase and tensin homology deleted on chromosome 10 (PTEN) gene transfection on reversal of multidrug resistance in K562/ADM cells. Leuk Lymphoma. 2012 Jul;53(7):1383-9. doi: 10.3109/10428194.2011.650695. Epub 2012 Jan 31.
52 Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature. 2001 Oct 25;413(6858):814-21.
53 In vitro metabolism of clindamycin in human liver and intestinal microsomes. Drug Metab Dispos. 2003 Jul;31(7):878-87.
54 Comparison of antimicrobial susceptibility, beta-lactamase production, plasmid analysis and serum bactericidal activity in Edwardsiella tarda, E. ictaluri and E. hoshinae. J Med Microbiol. 1993 Oct;39(4):273-81.
55 A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine. Drug Metab Dispos. 2008 Aug;36(8):1689-97.
56 Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
57 Chloramphenicol causes mitochondrial stress, decreases ATP biosynthesis, induces matrix metalloproteinase-13 expression, and solid-tumor cell invasion. Toxicol Sci. 2010 Jul;116(1):140-50. doi: 10.1093/toxsci/kfq085. Epub 2010 Mar 25.