Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDHYM7)

• Drug Name: Torcetrapib Drug Info
• Synonyms: Torcetrapib [USAN]; CP 529414; CP-529414; CP-529,414; Torcetrapib (USAN/INN); Ethyl (2R,4S)-4-[[3,5-bis(trifluoromethyl)phenyl]methyl-methoxycarbonylamino]-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylate; Ethyl (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino}-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate; Ethyl (2R,4S)-4-((3,5-bis(trifluoromethyl)benzyl)(methoxycarbonyl)amino)-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate; (2R,4S)-4-((3,5-Bis-trifluoromethylbenzyl)methoxycarbonylamino)-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester

Indication

Disease Entry	ICD 11	Status	REF
Hyperlipidaemia	5C80	Discontinued in Phase 2	[1]
Peripheral vascular disease	BD4Z	Discontinued in Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 159325
  ChEBI ID: CHEBI:49203
  CAS Number: CAS 262352-17-0
  TTD Drug ID: DMDHYM7
  INTEDE Drug ID: DR1786

Molecule-Related Drug Atlas

Drug(s) Targeting Cholesteryl ester transfer protein (CETP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Evacetrapib	DMCDZ15	Cardiovascular disease	BA00-BE2Z	Phase 3	[6]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[7]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[8]
JTT-302	DMGLVBI	Lipid metabolism disorder	5C52.Z	Phase 2	[6]
DRL-17822	DMGD3XT	Arteriosclerosis	BD40	Phase 2	[6]
TA-8995	DMAZHT0	Cardiovascular disease	BA00-BE2Z	Phase 2	[9]
BAY-60-5521	DMXIDWE	Arteriosclerosis	BD40	Phase 1	[10]
CETi-1	DMUG5OB	Arteriosclerosis	BD40	Discontinued in Phase 2	[11]
CP-800569	DMZ0YU7	Arteriosclerosis	BD40	Discontinued in Phase 1	[12]
R7232	DMETAP8	Dyslipidemia	5C80-5C81	Discontinued in Phase 1	[7]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[13]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[14]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[15]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[19]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[20]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[14]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[21]

Drug(s) Affected By CCN family member 1 (CCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[22]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[23]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[29]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]

Drug(s) Affected By Cytochrome P450 11B1, mitochondrial (CYP11B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[31]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[35]
Potassium Chloride	DMMTAJC	Hypokalemia	5C77	Approved	[36]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[39]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[39]

Drug(s) Affected By Cytochrome P450 11B2, mitochondrial (CYP11B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[40]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[32]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Potassium Chloride	DMMTAJC	Hypokalemia	5C77	Approved	[36]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[42]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[43]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[41]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[44]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[45]

Drug(s) Affected By Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[46]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[48]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[51]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 2 (NR4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[60]

Drug(s) Affected By GTP-binding protein GEM (GEM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[67]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]

Drug(s) Affected By Rho-related GTP-binding protein RhoB (RHOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[70]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[71]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[73]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase A (PPIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]

Drug(s) Affected By cAMP-responsive element modulator (CREM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[80]
Bortezomib	DMNO38U	Leukemia		Approved	[81]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[82]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 3 (NR4A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[23]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[87]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[89]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[23]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[90]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[38]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[95]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Fructose	DM43AN2	Vomiting	MD90	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]

Drug(s) Affected By Ciliary microtubule inner protein 2B (CIMIP2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[100]

Drug(s) Affected By Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[26]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[104]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]

Drug(s) Affected By Golgi integral membrane protein 4 (GOLIM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[106]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[106]

Drug(s) Affected By AP-3 complex subunit delta-1 (AP3D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[112]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[113]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[114]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]

Drug(s) Affected By Transportin-2 (TNPO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[117]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[116]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[121]

Drug(s) Affected By Ras-related protein M-Ras (MRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[122]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[51]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[123]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[125]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[126]

Drug(s) Affected By Probable proton-coupled zinc antiporter SLC30A4 (SLC30A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[127]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[128]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[129]

Drug(s) Affected By Peripheral plasma membrane protein CASK (CASK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[131]

Drug(s) Affected By Myosin regulatory light chain 12B (MYL12B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[134]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[135]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[136]

Drug(s) Affected By Period circadian protein homolog 2 (PER2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[136]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[140]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[141]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[142]

Drug(s) Affected By Suppressor of cytokine signaling 1 (SOCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[143]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[67]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[68]
Lomustine	DMMWSUL	Brain cancer	2A00	Approved	[144]

Drug(s) Affected By Leucine-rich repeat transmembrane protein FLRT2 (FLRT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[145]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[146]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[147]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[149]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[150]

Drug(s) Affected By RNA binding protein fox-1 homolog 2 (RBFOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[151]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[116]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[65]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[121]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[152]

Drug(s) Affected By Trans-Golgi network integral membrane protein 2 (TGOLN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[153]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[153]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[154]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF13 (RNF13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[155]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[125]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]

Drug(s) Affected By Protein sprouty homolog 2 (SPRY2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[157]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By 17S U2 SnRNP complex component HTATSF1 (HTATSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[111]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[159]

Drug(s) Affected By Double-strand-break repair protein rad21 homolog (RAD21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[162]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[151]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[163]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[164]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[165]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[166]

Drug(s) Affected By Microphthalmia-associated transcription factor (MITF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[168]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[170]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[171]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]

Drug(s) Affected By DnaJ homolog subfamily C member 13 (DNAJC13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[54]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[173]

Drug(s) Affected By Phosphatase and actin regulator 2 (PHACTR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[82]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[150]

Drug(s) Affected By Transforming acidic coiled-coil-containing protein 1 (TACC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[175]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]

Drug(s) Affected By Bis(monoacylglycero)phosphate synthase CLN5 (CLN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]

Drug(s) Affected By Krueppel-like factor 7 (KLF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[81]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[176]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[177]

Drug(s) Affected By Serine hydrolase RBBP9 (RBBP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[81]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[178]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[179]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]

Drug(s) Affected By Ubiquitin-like protein ATG12 (ATG12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[182]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[183]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[185]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]

Drug(s) Affected By Cyclin-dependent kinase 14 (CDK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[54]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[121]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[186]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[188]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[189]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[188]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[190]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[192]

Drug(s) Affected By Transferrin receptor protein 1 (TFRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[194]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[196]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[198]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[199]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[202]

Drug(s) Affected By Annexin A1 (ANXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[203]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[134]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[135]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[205]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[206]
Fructose	DM43AN2	Vomiting	MD90	Approved	[38]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[207]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[208]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[189]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[210]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[211]

Drug(s) Affected By Complement decay-accelerating factor (CD55)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[212]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[215]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]

Drug(s) Affected By Inhibin beta A chain (INHBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[145]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[89]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[216]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[217]

Drug(s) Affected By Steryl-sulfatase (STS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[23]
Tazarotene	DM8SMD1	Acne vulgaris	ED80	Approved	[218]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Danazol	DML8KTN	Menorrhagia	GA20.50	Approved	[219]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[218]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[23]

Drug(s) Affected By Putative inactive neutral ceramidase B (ASAH2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[220]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[221]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[223]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[224]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[223]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[223]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[223]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[225]

Drug(s) Affected By Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (DBT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[199]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[147]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[123]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[121]

Drug(s) Affected By Nucleoprotein TPR (TPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[228]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[229]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[229]

Drug(s) Affected By Poliovirus receptor (PVR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[127]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]

Drug(s) Affected By Fos-related antigen 2 (FOSL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[71]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[106]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By Transcription factor 4 (TCF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[231]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[231]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[234]

Drug(s) Affected By Histone H1.3 (H1-3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[235]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[236]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[237]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[238]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[227]

Drug(s) Affected By Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[198]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[239]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[240]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[241]

Drug(s) Affected By Transcription factor JunB (JUNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[208]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[242]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[243]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[244]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[64]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 2 (PTPN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[246]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[247]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[248]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[209]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[239]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[22]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[249]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[250]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[24]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[251]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[252]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[200]

Drug(s) Affected By Ras-related protein Rab-3B (RAB3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[253]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[254]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By Cation-dependent mannose-6-phosphate receptor (M6PR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[255]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[154]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[237]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[256]

Drug(s) Affected By Kit ligand (KITLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[257]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[258]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[254]

Drug(s) Affected By E3 ubiquitin-protein ligase CBL (CBL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[260]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[123]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]

Drug(s) Affected By cAMP-dependent protein kinase catalytic subunit beta (PRKACB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[200]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[81]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[262]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[123]

Drug(s) Affected By Tyrosine-protein kinase JAK1 (JAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[199]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[155]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[265]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[242]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[267]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[239]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[189]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[269]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[249]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[271]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[272]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[273]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[274]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[275]

Drug(s) Affected By Rab proteins geranylgeranyltransferase component A 2 (CHML)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[125]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]

Drug(s) Affected By Microtubule-associated protein 4 (MAP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[121]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[229]

Drug(s) Affected By Protein ITPRID2 (ITPRID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[67]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[137]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[82]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]

Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[189]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[277]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[278]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[279]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[280]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[48]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]

Drug(s) Affected By Tripeptidyl-peptidase 2 (TPP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[281]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[281]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[281]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[113]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[54]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[283]

Drug(s) Affected By Fibroblast growth factor 9 (FGF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[284]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[67]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[157]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[146]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[285]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[111]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[286]

Drug(s) Affected By RAC-beta serine/threonine-protein kinase (AKT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[287]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[288]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[243]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[249]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[289]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[260]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[290]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[291]

Drug(s) Affected By ETS-related transcription factor Elf-1 (ELF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[161]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]

Drug(s) Affected By Cystathionine gamma-lyase (CTH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[239]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[199]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[239]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[106]

Drug(s) Affected By Merlin (NF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[293]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[294]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[295]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[137]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM23 (TRIM23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[296]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[297]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[179]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[66]

Drug(s) Affected By TGF-beta receptor type-2 (TGFBR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[298]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[299]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[300]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[252]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[199]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[301]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]

Drug(s) Affected By Interleukin-6 receptor subunit beta (IL6ST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[243]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[303]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[304]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[304]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]

Drug(s) Affected By Regulator of G-protein signaling 2 (RGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[62]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[301]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]

Drug(s) Affected By Endothelin-converting enzyme 1 (ECE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[305]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[306]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[67]
Metoprolol	DMOJ0V6	Acute coronary syndrome	BA41	Approved	[307]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[308]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]

Drug(s) Affected By Transcriptional regulator ATRX (ATRX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[310]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[311]

Drug(s) Affected By Lys-63-specific deubiquitinase BRCC36 (BRCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[212]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[295]
Bortezomib	DMNO38U	Leukemia		Approved	[81]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[241]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[159]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]

Drug(s) Affected By DNA-binding protein inhibitor ID-4 (ID4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[67]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[312]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[216]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]

Drug(s) Affected By Glioma pathogenesis-related protein 1 (GLIPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[313]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[81]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[80]

Drug(s) Affected By Choline-phosphate cytidylyltransferase A (PCYT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Bortezomib	DMNO38U	Leukemia		Approved	[81]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[314]
G1	DMTV42K	Lymphoma	2A80-2A86	Phase 1/2	[315]

Drug(s) Affected By Protein Tob1 (TOB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[249]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[81]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[316]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]

Drug(s) Affected By Ras-related protein Rab-5C (RAB5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[296]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[137]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[227]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[317]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[317]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 7 (PSMD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[318]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[215]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[229]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[229]
Bortezomib	DMNO38U	Leukemia		Approved	[81]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[319]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[320]

Drug(s) Affected By AF4/FMR2 family member 2 (AFF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[321]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]

Drug(s) Affected By E3 ubiquitin-protein ligase TTC3 (TTC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[228]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[175]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[175]

Drug(s) Affected By Puromycin-sensitive aminopeptidase (NPEPPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[249]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[322]

Drug(s) Affected By Serine/threonine-protein kinase SIK1 (SIK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[106]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[323]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[106]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[106]

Drug(s) Affected By Epiplakin (EPPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[127]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[285]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[324]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]

Drug(s) Affected By Transforming growth factor beta-2 proprotein (TGFB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[325]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[243]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[326]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[327]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[122]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By DDB1- and CUL4-associated factor 7 (DCAF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[111]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[57]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[328]

Drug(s) Affected By Tropomyosin alpha-4 chain (TPM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[329]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[25]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[330]

Drug(s) Affected By Coxsackievirus and adenovirus receptor (CXADR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[331]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[331]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[147]

Drug(s) Affected By Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (PIP4K2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[332]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[333]

Drug(s) Affected By Arginase-2, mitochondrial (ARG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[334]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[335]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[199]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[336]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[337]

Drug(s) Affected By Protein BTG2 (BTG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[22]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[338]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[339]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[340]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[280]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[235]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[134]

Drug(s) Affected By Interleukin-13 receptor subunit alpha-1 (IL13RA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[212]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[199]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[341]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[342]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[212]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[343]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[344]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[345]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[346]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[347]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[348]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[349]

Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[350]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[351]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[352]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[353]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[354]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]

Drug(s) Affected By OTU domain-containing protein 4 (OTUD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[127]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[121]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[54]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[69]

Drug(s) Affected By Myocyte-specific enhancer factor 2A (MEF2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[355]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[356]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[123]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[357]

Drug(s) Affected By Dystonin (DST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[310]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[127]

Drug(s) Affected By Histone-lysine N-methyltransferase 2A (KMT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[358]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[359]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[360]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[361]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[362]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]

Drug(s) Affected By Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[363]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[364]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[123]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[296]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]

Drug(s) Affected By Transducin-like enhancer protein 4 (TLE4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[67]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[365]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[366]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[147]

Drug(s) Affected By Proto-oncogene c-Rel (REL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[277]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[329]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[367]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[368]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[369]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[216]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[370]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[371]

Drug(s) Affected By Caldesmon (CALD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[372]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[199]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[373]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[229]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[82]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[374]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[67]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[365]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[375]

Drug(s) Affected By Golgin subfamily A member 2 (GOLGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[127]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[365]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[154]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[314]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[376]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[309]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By Leukocyte surface antigen CD47 (CD47)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[212]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[285]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]

Drug(s) Affected By TP53-binding protein 1 (TP53BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[377]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[378]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[322]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[379]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[380]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]

Drug(s) Affected By Interleukin enhancer-binding factor 3 (ILF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[241]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[220]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[227]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[317]

Drug(s) Affected By Ankyrin-3 (ANK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[381]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[365]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[322]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[137]

Drug(s) Affected By Serine/threonine-protein kinase 4 (STK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[285]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Bortezomib	DMNO38U	Leukemia		Approved	[382]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[116]

Drug(s) Affected By Zinc transporter ZIP6 (SLC39A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[46]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[383]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[384]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[147]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[46]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]

Drug(s) Affected By DNA topoisomerase 3-alpha (TOP3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[338]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[338]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[338]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[338]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
Lithium chloride	DMHYLQ2	Discovery agent	N.A.	Investigative	[385]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[386]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[321]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[239]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[334]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[387]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[388]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[389]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[390]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[391]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[392]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[200]

Drug(s) Affected By ARF GTPase-activating protein GIT2 (GIT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[123]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[112]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[393]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[121]

Drug(s) Affected By Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[394]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[322]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[137]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[111]

Drug(s) Affected By RNA-binding protein 39 (RBM39)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[395]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[396]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[397]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[159]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]

Drug(s) Affected By Inositol 1,4,5-trisphosphate receptor type 2 (ITPR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[363]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[398]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]

Drug(s) Affected By Structural maintenance of chromosomes protein 1A (SMC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[257]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[399]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[299]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[399]
Bortezomib	DMNO38U	Leukemia		Approved	[81]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 4 (CHD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[71]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[229]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[229]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]

Drug(s) Affected By HUWE1-associated protein modifying stress responses 1 (HAPSTR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[84]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[328]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[159]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[400]

Drug(s) Affected By Squamous cell carcinoma antigen recognized by T-cells 3 (SART3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[127]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[111]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[116]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]

Drug(s) Affected By Pericentriolar material 1 protein (PCM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[310]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]

Drug(s) Affected By Angiopoietin-1 (ANGPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[401]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[402]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[403]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 14 (PTPN14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[127]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[404]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[147]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[297]

Drug(s) Affected By NGFI-A-binding protein 2 (NAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[242]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[405]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[89]
Bortezomib	DMNO38U	Leukemia		Approved	[81]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[406]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[407]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[189]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[408]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[409]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[410]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[411]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[412]

Drug(s) Affected By snRNA-activating protein complex subunit 1 (SNAPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]

Drug(s) Affected By Beta-sarcoglycan (SGCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[413]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[414]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[151]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[173]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[66]

Drug(s) Affected By Nuclear factor interleukin-3-regulated protein (NFIL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[239]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[249]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[335]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]

Drug(s) Affected By kinase isozyme 4, mitochondrial (PDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[415]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[417]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[106]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[106]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]

Drug(s) Affected By Gamma-interferon-inducible protein 16 (IFI16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[418]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]

Drug(s) Affected By Cytoplasmic polyadenylation element-binding protein 4 (CPEB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[71]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[419]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[125]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[396]

Drug(s) Affected By LON peptidase N-terminal domain and RING finger protein 2 (LONRF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[147]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[321]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]

Drug(s) Affected By Hereditary hemochromatosis protein (HFE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[147]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[57]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[420]
cinnamaldehyde	DMZDUXG	Discovery agent	N.A.	Investigative	[421]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[422]

Drug(s) Affected By Erythroid differentiation-related factor 1 (EDRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[423]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[227]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[424]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 9 (CHD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[310]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[127]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[159]

Drug(s) Affected By Girdin (CCDC88A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By AT-rich interactive domain-containing protein 4B (ARID4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[425]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]

Drug(s) Affected By Rho GTPase-activating protein 29 (ARHGAP29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[121]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[426]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By INO80 complex subunit D (INO80D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[309]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[228]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[250]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[57]

Drug(s) Affected By Exosome complex component MTR3 (EXOSC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[65]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[100]

Drug(s) Affected By Opioid growth factor receptor-like protein 1 (OGFRL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[89]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[82]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[147]

Drug(s) Affected By Telomere-associated protein RIF1 (RIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[84]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[427]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]

Drug(s) Affected By Muscleblind-like protein 2 (MBNL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[310]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[262]

Drug(s) Affected By Centriole, cilia and spindle-associated protein (CCSAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[376]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]

Drug(s) Affected By Glucose 1,6-bisphosphate synthase (PGM2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[285]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]

Drug(s) Affected By Kelch domain-containing protein 10 (KLHDC10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[62]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[116]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[156]

Drug(s) Affected By Consortin (CNST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[153]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[111]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[153]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[428]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]

Drug(s) Affected By Kelch-like protein 24 (KLHL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[429]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[429]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]

Drug(s) Affected By Ankyrin repeat domain-containing protein 11 (ANKRD11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[249]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[430]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[137]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[324]

Drug(s) Affected By Very-long-chain (HACD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[89]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[431]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[111]

Drug(s) Affected By Membrane progestin receptor epsilon (PAQR9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[419]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]

Drug(s) Affected By Lysophosphatidylcholine acyltransferase 2 (LPCAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[252]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[321]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]

Drug(s) Affected By Probable helicase senataxin (SETX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[106]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[229]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[106]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[159]

Drug(s) Affected By Protein mono-ADP-ribosyltransferase TIPARP (TIPARP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[235]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[106]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]

Drug(s) Affected By SUZ domain-containing protein 1 (SZRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[243]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[322]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[227]

Drug(s) Affected By Sprouty-related, EVH1 domain-containing protein 1 (SPRED1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[127]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[90]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[147]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]

Drug(s) Affected By E3 ubiquitin-protein ligase RBBP6 (RBBP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[432]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[260]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By UPF0461 protein C5orf24 (C5ORF24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[69]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[159]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[54]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[69]

Drug(s) Affected By Protein prenyltransferase alpha subunit repeat-containing protein 1 (PTAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[393]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[54]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[69]

Drug(s) Affected By Uncharacterized protein C11orf96 (C11ORF96)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[419]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[175]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]

Drug(s) Affected By Protein PAT1 homolog 1 (PATL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[433]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]

Drug(s) Affected By RNA N6-adenosine-methyltransferase METTL16 (METTL16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[54]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[320]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[434]

Drug(s) Affected By Liprin-beta-1 (PPFIBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[228]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[106]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[106]

Drug(s) Affected By CDK2-associated and cullin domain-containing protein 1 (CACUL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[156]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[435]

Drug(s) Affected By ELKS/Rab6-interacting/CAST family member 1 (ERC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[254]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[285]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[175]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[175]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[57]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[128]

Drug(s) Affected By Protein NOXP20 (FAM114A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[436]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[126]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[69]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]

Drug(s) Affected By Angiomotin-like protein 1 (AMOTL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[323]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[425]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[437]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[438]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[54]

Drug(s) Affected By Fanconi anemia group M protein (FANCM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[257]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[157]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[123]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]

Drug(s) Affected By ORM1-like protein 3 (ORMDL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[156]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[434]

Drug(s) Affected By Mitochondrial cardiolipin hydrolase (PLD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[84]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[439]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF152 (RNF152)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[156]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[100]

Drug(s) Affected By Protein SCAI (SCAI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[285]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]

Drug(s) Affected By NFATC2-interacting protein (NFATC2IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[121]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[365]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[256]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[159]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[121]

Drug(s) Affected By EH domain-binding protein 1 (EHBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[430]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]

Drug(s) Affected By Polyhomeotic-like protein 3 (PHC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Bortezomib	DMNO38U	Leukemia		Approved	[81]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[121]

Drug(s) Affected By Protein Lines homolog 1 (LINS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[81]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[440]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[440]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[320]

Drug(s) Affected By Small VCP/p97-interacting protein (SVIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[69]

Drug(s) Affected By DnaJ homolog subfamily B member 14 (DNAJB14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[228]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[123]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[123]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[156]

Drug(s) Affected By POC1 centriolar protein homolog B (POC1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Bortezomib	DMNO38U	Leukemia		Approved	[81]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[441]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[441]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]

Drug(s) Affected By Protein bicaudal D homolog 2 (BICD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[425]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[376]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[116]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[114]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[121]

Drug(s) Affected By Palladin (PALLD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[334]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]

Drug(s) Affected By Splicing regulatory glutamine/lysine-rich protein 1 (SREK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[395]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[229]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[425]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[395]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[159]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[121]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[442]

Drug(s) Affected By Stonin-2 (STON2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[443]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[431]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[147]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[256]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]

Drug(s) Affected By Cysteine/serine-rich nuclear protein 3 (CSRNP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[147]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]

Drug(s) Affected By Protein ELYS (AHCTF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[125]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[444]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]

Drug(s) Affected By Protein LZIC (LZIC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[435]

Drug(s) Affected By Immunity-related GTPase family Q protein (IRGQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[217]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[283]

Drug(s) Affected By Heat shock protein 105 kDa (HSPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[445]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[429]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[446]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[48]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[447]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]

Drug(s) Affected By Amyloid beta precursor protein binding family B member 2 (APBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[137]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[216]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]

Drug(s) Affected By SWI/SNF complex subunit SMARCC1 (SMARCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[351]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[254]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[125]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[227]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[116]

Drug(s) Affected By Protein tyrosine phosphatase type IVA 1 (PTP4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[338]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[448]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[89]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[285]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[338]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[449]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[199]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[295]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[217]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]

Drug(s) Affected By Ataxin-7-like protein 3B (ATXN7L3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[333]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[54]

Drug(s) Affected By PDZ and LIM domain protein 5 (PDLIM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Haloperidol	DM96SE0	Delirium		Approved	[229]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[127]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[229]

Drug(s) Affected By Terminal nucleotidyltransferase 5A (TENT5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[363]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[365]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]

Drug(s) Affected By Serine/Arginine-related protein 53 (RSRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[81]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[450]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[248]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[156]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[58]

Drug(s) Affected By E3 ubiquitin-protein ligase Itchy homolog (ITCH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[451]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[396]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[156]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[100]

Drug(s) Affected By ADP-ribosylation factor-like protein 5B (ARL5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[81]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]

Drug(s) Affected By E1A-binding protein p400 (EP400)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[121]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[106]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[106]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[106]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]

Drug(s) Affected By CCR4-NOT transcription complex subunit 6-like (CNOT6L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[319]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[452]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[58]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[66]

Drug(s) Affected By Sphingomyelin synthase-related protein 1 (SAMD8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]

Drug(s) Affected By Prickle-like protein 1 (PRICKLE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[89]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[430]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[147]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[150]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[69]

Drug(s) Affected By Germ cell nuclear acidic protein (GCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[429]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[453]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[65]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[454]

Drug(s) Affected By Transcriptional regulator protein Pur-beta (PURB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[229]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[333]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[121]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[121]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[319]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[455]

Drug(s) Affected By Tribbles homolog 1 (TRIB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]

Drug(s) Affected By Cysteine/serine-rich nuclear protein 1 (CSRNP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[456]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[136]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By Protein IWS1 homolog (IWS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[111]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[159]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[121]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[121]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[420]

Drug(s) Affected By Centrosomal protein of 89 kDa (CEP89)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[436]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[121]

Drug(s) Affected By Sphingosine 1-phosphate receptor 3 (S1PR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[457]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[451]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[89]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[458]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]

Drug(s) Affected By Protein SCAF11 (SCAF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[228]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[310]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]

Drug(s) Affected By Krueppel-like factor 6 (KLF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[459]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[338]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[26]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]

Drug(s) Affected By Suppressor of IKBKE 1 (SIKE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[436]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[209]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[54]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[100]

Drug(s) Affected By Dynactin subunit 5 (DCTN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[58]

Drug(s) Affected By tRNA (THUMPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[460]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[121]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[121]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[58]

Drug(s) Affected By Cell cycle regulator of non-homologous end joining (CYREN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[461]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[256]

Drug(s) Affected By Poly(A) polymerase gamma (PAPOLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[396]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[462]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[121]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[320]

Drug(s) Affected By Protein LSM14 homolog B (LSM14B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[179]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[121]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[54]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[121]

Drug(s) Affected By N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[203]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[228]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[241]

Drug(s) Affected By FSD1-like protein (FSD1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[67]
Bortezomib	DMNO38U	Leukemia		Approved	[81]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[209]

Drug(s) Affected By Dual specificity protein phosphatase 16 (DUSP16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[189]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[463]

Drug(s) Affected By NF-kappa-B inhibitor zeta (NFKBIZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[276]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[464]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[67]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[295]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[199]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[465]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[81]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[90]

Drug(s) Affected By Tripartite motif-containing protein 2 (TRIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[137]

Drug(s) Affected By Egl nine homolog 1 (EGLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[466]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[200]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[467]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[200]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By Nucleoporin-62 C-terminal-like protein (NUP62CL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[323]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[311]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]

Drug(s) Affected By Homeodomain-interacting protein kinase 2 (HIPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[468]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]

Drug(s) Affected By Protein salvador homolog 1 (SAV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[89]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[100]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[469]

Drug(s) Affected By HEAT repeat-containing protein 1 (HEATR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[84]

Drug(s) Affected By Threonine aspartase 1 (TASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[65]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]

Drug(s) Affected By Serine-rich coiled-coil domain-containing protein 2 (CCSER2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]

Drug(s) Affected By Jupiter microtubule associated homolog 2 (JPT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[111]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[151]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[470]

Drug(s) Affected By Akirin-1 (AKIRIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[65]

Drug(s) Affected By Pleckstrin homology domain-containing family A member 2 (PLEKHA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[467]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[365]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[90]

Drug(s) Affected By Putative divalent cation/proton antiporter TMEM165 (TMEM165)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[469]

Drug(s) Affected By Casein kinase I isoform gamma-1 (CSNK1G1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[309]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]

Drug(s) Affected By SIN3-HDAC complex-associated factor (SINHCAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
ACYLINE	DM9GRTK	Prostate cancer	2C82.0	Phase 2	[471]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[472]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[313]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]

Drug(s) Affected By L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (AASDHPPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]

Drug(s) Affected By 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (AGPAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[137]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF19A (RNF19A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[295]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[111]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]

Drug(s) Affected By Septin-11 (SEPTIN11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[199]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[473]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[111]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[444]

Drug(s) Affected By F-box only protein 28 (FBXO28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[357]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[156]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[100]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[66]

Drug(s) Affected By Exonuclease 3'-5' domain-containing protein 2 (EXD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[425]

Drug(s) Affected By HAUS augmin-like complex subunit 2 (HAUS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[425]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[474]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]

Drug(s) Affected By DDB1- and CUL4-associated factor 16 (DCAF16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[475]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[69]

Drug(s) Affected By Inhibitor of growth protein 3 (ING3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[48]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[285]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[125]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[57]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[476]

Drug(s) Affected By Serine/threonine-protein kinase PLK2 (PLK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[477]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[89]

Drug(s) Affected By ]-phosphatase 1, mitochondrial (PDP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Indomethacin	DMSC4A7	Bursitis		Approved	[478]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[220]

Drug(s) Affected By SLAIN motif-containing protein 2 (SLAIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[323]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[376]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[121]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[54]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[121]

Drug(s) Affected By Leucine--tRNA ligase, cytoplasmic (LARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[106]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[106]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[106]

Drug(s) Affected By Myotilin (MYOT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[337]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[179]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]

Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (GNG12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[403]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[254]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[54]

Drug(s) Affected By Protein sel-1 homolog 1 (SEL1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[479]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[336]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[254]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[451]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[241]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]

Drug(s) Affected By Probable ribosome biogenesis protein RLP24 (RSL24D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[322]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[480]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[481]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[400]

Drug(s) Affected By LIM domain and actin-binding protein 1 (LIMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[482]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Bortezomib	DMNO38U	Leukemia		Approved	[81]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[229]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[229]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[430]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[241]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[248]

Drug(s) Affected By F-box/LRR-repeat protein 4 (FBXL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[328]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[58]

Drug(s) Affected By DnaJ homolog subfamily C member 12 (DNAJC12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[332]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]

Drug(s) Affected By DCC-interacting protein 13-alpha (APPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[111]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[121]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[156]

Drug(s) Affected By Muskelin (MKLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[333]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[483]

Drug(s) Affected By Protein BCAP (ODF2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[310]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[484]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[156]

Drug(s) Affected By E3 ubiquitin-protein ligase HECTD1 (HECTD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[65]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[121]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[54]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[173]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[69]

Drug(s) Affected By Frizzled-10 (FZD10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[311]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[145]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[156]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[100]

Drug(s) Affected By Unconventional myosin-VI (MYO6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[473]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[310]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[254]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]

Drug(s) Affected By Translocon-associated protein subunit gamma (SSR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[485]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[127]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[229]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]

Drug(s) Affected By Structural maintenance of chromosomes protein 3 (SMC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Bortezomib	DMNO38U	Leukemia		Approved	[81]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[146]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[241]

Drug(s) Affected By RAC-gamma serine/threonine-protein kinase (AKT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[260]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[147]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[291]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[151]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 2 (MAP3K2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[121]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[81]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[65]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[121]

Drug(s) Affected By PRELI domain containing protein 3B (PRELID3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[396]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[151]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[151]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[121]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[173]

Drug(s) Affected By Pygopus homolog 1 (PYGO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[295]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[376]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[54]

Drug(s) Affected By TRPM8 channel-associated factor 1 (TCAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Haloperidol	DM96SE0	Delirium		Approved	[229]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[229]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[229]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By Nuclear protein AMMECR1 (AMMECR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[486]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[487]

Drug(s) Affected By Protein PRRC2C (PRRC2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By Low-density lipoprotein receptor-related protein 12 (LRP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[147]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]

Drug(s) Affected By Krueppel-like factor 2 (KLF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[62]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[234]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[175]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[124]

Drug(s) Affected By Sorting nexin-13 (SNX13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[332]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[116]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[121]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[256]

Drug(s) Affected By EP300-interacting inhibitor of differentiation 1 (EID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[241]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[65]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[115]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[488]
bilirubin	DMI0V4O	Discovery agent	N.A.	Investigative	[489]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[469]

Drug(s) Affected By Nuclear receptor coactivator 3 (NCOA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[242]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[318]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[490]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[228]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[59]
Bortezomib	DMNO38U	Leukemia		Approved	[81]

Drug(s) Affected By Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[491]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[242]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[492]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[493]

Drug(s) Affected By Cytochrome b-245 heavy chain (CYBB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[494]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[495]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[321]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[227]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[39]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[39]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[496]

Drug(s) Affected By Mineralocorticoid receptor (NR3C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[497]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[498]
Triamcinolone	DM98IXF	Acute adrenal insufficiency		Approved	[499]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[500]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[499]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[499]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[499]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[501]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[502]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[503]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[504]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[505]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[506]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[507]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[508]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[509]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[510]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[38]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[212]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[511]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[512]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[513]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[514]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[515]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[516]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[517]

Drug(s) Affected By NADPH oxidase 5 (NOX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[518]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[519]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[39]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[114]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[520]

Drug(s) Affected By Retinoic acid receptor responder protein 2 (RARRES2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[521]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[89]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[522]

Drug(s) Affected By NADPH oxidase 4 (NOX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[523]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[524]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[525]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[526]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[252]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[527]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[255]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[528]

Drug(s) Affected By NADPH oxidase 1 (NOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[365]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[529]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[39]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[39]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[530]
Acteoside	DM0YHKB	Nephritis	GB40	Terminated	[531]
U0126	DM31OGF	Discovery agent	N.A.	Investigative	[532]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[533]

Drug(s) Affected By Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[534]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[32]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[535]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[536]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[537]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[537]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[538]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[539]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[539]
ABIRATERONE	DM8V75C	Prostate cancer	2C82.0	Approved	[540]

Drug(s) Affected By Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[536]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[289]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[541]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[35]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[542]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[543]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[544]

Drug(s) Affected By Steroid 21-hydroxylase (CYP21A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[243]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[545]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[83]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[172]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[546]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[99]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[547]
3-MeSO2-DDE	DMAWEQH	Discovery agent	N.A.	Investigative	[37]

Drug(s) Affected By 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[535]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[539]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[539]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[541]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Metyrapone	DMI7FVQ	Cushing disease	5A70	Approved	[547]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[535]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[365]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[548]
Levetiracetam	DMTGDN8	Epilepsy	8A60-8A68	Approved	[44]

Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[534]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[436]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[541]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[467]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[549]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[145]

Drug(s) Affected By Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[550]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[551]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[552]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[157]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[111]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[85]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[484]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cholesteryl ester transfer protein (CETP)	TTFQAYR	CETP_HUMAN	Inhibitor	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (AGPAT3)	OTAUR5TG	PLCC_HUMAN	Gene/Protein Processing	[4]
17S U2 SnRNP complex component HTATSF1 (HTATSF1)	OTLQ1ZLS	HTSF1_HUMAN	Gene/Protein Processing	[4]
26S proteasome non-ATPase regulatory subunit 7 (PSMD7)	OT7PZZ4K	PSMD7_HUMAN	Gene/Protein Processing	[4]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2)	OT02MSKN	3BHS2_HUMAN	Gene/Protein Processing	[5]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)	OTOA8WU2	PDE4B_HUMAN	Gene/Protein Processing	[4]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)	OT1RWFV0	PDE4D_HUMAN	Gene/Protein Processing	[4]
ADP-ribosylation factor-like protein 5B (ARL5B)	OTYYBIDG	ARL5B_HUMAN	Gene/Protein Processing	[4]
AF4/FMR2 family member 2 (AFF2)	OTMF1PZW	AFF2_HUMAN	Gene/Protein Processing	[4]
Akirin-1 (AKIRIN1)	OTINWTT9	AKIR1_HUMAN	Gene/Protein Processing	[4]
Amyloid beta precursor protein binding family B member 2 (APBB2)	OT1VD51B	APBB2_HUMAN	Gene/Protein Processing	[4]

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