Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGZQEF)

• Drug Name: Mifepristone Drug Info
• Synonyms: Mifedren; HRA-052015; Mifepristone (Cushing's disease); ACTH modulator (Cushing's disease), HRA; Adrenocorticotropic hormone modulator (Cushing's disease), HRA Pharma; Mifepristone (Cushing's disease), HRA pharma

Indication

Disease Entry	ICD 11	Status	REF
Cushing disease	5A70	Approved	[1]

• Cross-matching ID:
  PubChem CID: 55245
  ChEBI ID: CHEBI:50692
  CAS Number: CAS 84371-65-3
  TTD Drug ID: DMGZQEF
  VARIDT Drug ID: DR00714
  INTEDE Drug ID: DR1091
  ACDINA Drug ID: D00432

Molecule-Related Drug Atlas

Drug(s) Targeting Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[7]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[8]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[9]
Fluticasone	DMGCSVF	Allergic rhinitis	CA08.0	Approved	[10]
Betamethasone Valerate	DMMIAXO	Dermatological disease	DA24.Y	Approved	[8]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Deflazacort	DMV0RNS	Duchenne dystrophy	8C70	Approved	[8]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[11]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[12]
Fluocinolone Acetonide	DMG2KI4	Choroiditis		Approved	[8]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[504]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[234]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[583]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[584]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[13]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[14]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[15]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[19]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[20]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[14]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[21]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[31]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[32]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[33]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[34]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[35]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[36]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[37]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[38]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[39]

Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[23]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[26]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[27]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[29]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[30]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[25]

Drug(s) Affected By Pro-neuropeptide Y (NPY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Guanethidine	DM9NSWT	Moderate and severe hypertension	BA00.Z	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[46]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[47]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[42]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[50]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[51]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[54]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[55]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[56]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]

Drug(s) Affected By Frizzled-9 (FZD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[60]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[62]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[65]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[67]

Drug(s) Affected By Forkhead box protein N3 (FOXN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[75]

Drug(s) Affected By Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[68]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[78]

Drug(s) Affected By Actin-binding LIM protein 1 (ABLIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[85]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[87]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[88]

Drug(s) Affected By Ectoderm-neural cortex protein 1 (ENC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[90]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]

Drug(s) Affected By Histone-lysine N-methyltransferase 2D (KMT2D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[95]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[81]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[81]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[99]

Drug(s) Affected By 17-beta-hydroxysteroid dehydrogenase type 6 (HSD17B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[58]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[42]

Drug(s) Affected By Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[105]
Haloperidol	DM96SE0	Delirium		Approved	[106]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[105]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[105]

Drug(s) Affected By Calpain-5 (CAPN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[108]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[109]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[110]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]

Drug(s) Affected By Leucine-rich repeat transmembrane protein FLRT2 (FLRT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[87]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[112]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[114]

Drug(s) Affected By Septin-4 (SEPTIN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[116]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[117]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[62]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[120]

Drug(s) Affected By Cationic amino acid transporter 4 (SLC7A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[121]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[122]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[123]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[124]

Drug(s) Affected By Proline dehydrogenase 1, mitochondrial (PRODH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[125]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[126]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[100]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[127]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[128]

Drug(s) Affected By Synaptogyrin-1 (SYNGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[103]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[117]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[117]

Drug(s) Affected By C-X-C motif chemokine 13 (CXCL13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[114]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[131]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[58]
MG149	DM7V58G	Discovery agent	N.A.	Investigative	[132]
AMINOHIPPURIC ACID	DMUN54G	Discovery agent	N.A.	Investigative	[133]

Drug(s) Affected By Frizzled-6 (FZD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[135]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[120]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[135]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[120]

Drug(s) Affected By Sushi repeat-containing protein SRPX2 (SRPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]

Drug(s) Affected By Sorting nexin-2 (SNX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[137]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[138]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[139]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]

Drug(s) Affected By P antigen family member 4 (PAGE4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[114]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[42]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]

Drug(s) Affected By Slit homolog 3 protein (SLIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[103]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[95]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Nitazoxanide	DMOWLVG	Clostridioides difficile infection	1A04	Approved	[140]

Drug(s) Affected By Large neutral amino acids transporter small subunit 3 (SLC43A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[141]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[142]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[125]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[143]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[142]

Drug(s) Affected By Solute carrier family 22 member 3 (SLC22A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[144]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[144]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[144]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Phenoxybenzamine	DM8KSQH	Malignant essential hypertension	BA00	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[147]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[148]

Drug(s) Affected By E3 ubiquitin-protein ligase NEURL1 (NEURL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[62]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[149]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]

Drug(s) Affected By Cystatin-F (CST7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[151]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[152]
Bortezomib	DMNO38U	Leukemia		Approved	[153]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[154]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[75]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[156]

Drug(s) Affected By Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (B3GAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[124]
UDP-glucuronic acid	DMW16X2	Discovery agent	N.A.	Investigative	[157]

Drug(s) Affected By Myelin protein zero-like protein 1 (MPZL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[90]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[90]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[90]

Drug(s) Affected By Supervillin (SVIL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[160]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Mestranol	DMG3F94	Contraception	QA21	Approved	[160]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[162]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[160]

Drug(s) Affected By Follistatin-related protein 3 (FSTL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[162]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[163]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[164]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[165]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[95]

Drug(s) Affected By Protein LDOC1 (LDOC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[162]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[166]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]

Drug(s) Affected By Coagulation factor XIII A chain (F13A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[87]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[120]

Drug(s) Affected By Tissue-type plasminogen activator (PLAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[169]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[170]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[171]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[172]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[174]
Fructose	DM43AN2	Vomiting	MD90	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[177]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[178]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[179]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[180]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[183]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[184]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[185]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]

Drug(s) Affected By Prolactin (PRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[186]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[187]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[188]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[189]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[190]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[191]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[192]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[193]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[194]

Drug(s) Affected By Collagen alpha-1(II) chain (COL2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[148]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[196]
Indomethacin	DMSC4A7	Bursitis		Approved	[197]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[197]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[198]

Drug(s) Affected By Apolipoprotein C-I (APOC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[199]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[117]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[117]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]

Drug(s) Affected By Annexin A1 (ANXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[200]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[202]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[203]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[204]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[205]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[201]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[169]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[208]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[209]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[91]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[212]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[213]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[214]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[215]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[216]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[172]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[218]

Drug(s) Affected By Protein S100-A6 (S100A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[219]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[221]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[222]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]

Drug(s) Affected By Tyrosine 3-monooxygenase (TH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zonisamide	DM0DTF7	Alcohol dependence	6C40.2	Approved	[223]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[226]
Methamphetamine	DMPM4SK	Anxiety		Approved	[227]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[228]
Piperazine	DMTY9LU	Ascariasis	1F62	Approved	[229]

Drug(s) Affected By Decorin (DCN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[231]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[232]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[233]

Drug(s) Affected By Thrombospondin-1 (THBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[234]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[235]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[236]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[176]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[237]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[40]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[40]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[40]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[40]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[238]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[239]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[240]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[174]

Drug(s) Affected By Glutathione S-transferase A1 (GSTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[242]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[243]
Thiotepa	DMIZKOP	Breast cancer	2C60-2C65	Approved	[244]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[245]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[246]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[247]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[248]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[249]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]

Drug(s) Affected By Inhibin beta A chain (INHBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[203]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[250]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[251]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[252]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[253]

Drug(s) Affected By Matrilysin (MMP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[172]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[254]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[257]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[258]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[259]

Drug(s) Affected By Stromelysin-2 (MMP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[260]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[236]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[176]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Haloperidol	DM96SE0	Delirium		Approved	[106]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[260]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Selenium	DM25CGV	N. A.	N. A.	Approved	[261]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[201]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[236]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[176]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[262]

Drug(s) Affected By Fructose-bisphosphate aldolase C (ALDOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[263]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[264]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[265]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]

Drug(s) Affected By Glutathione S-transferase theta-2 (GSTT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[266]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[163]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[267]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[268]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[269]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[270]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[65]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[271]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[272]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[273]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[274]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[275]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[276]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[276]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[271]

Drug(s) Affected By Thyroid hormone receptor alpha (THRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[277]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[134]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[278]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[120]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[279]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[280]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]

Drug(s) Affected By Thyroid hormone receptor beta (THRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[281]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[108]

Drug(s) Affected By Pyruvate carboxylase, mitochondrial (PC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[120]

Drug(s) Affected By Creatine kinase B-type (CKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[234]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[283]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[284]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[285]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[286]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[287]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[288]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[289]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[290]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[291]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]

Drug(s) Affected By Cytochrome P450 4B1 (CYP4B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[292]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[295]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[162]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[62]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[296]

Drug(s) Affected By Retinoic acid receptor gamma (RARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[297]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[298]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[108]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[299]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[62]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[300]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[301]

Drug(s) Affected By HLA class II histocompatibility antigen, DO beta chain (HLA-DOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meropenem	DM62UHC	Bacterial infection	1A00-1C4Z	Approved	[302]
Trimethoprim	DMM7CHK	Acute otitis media	AB00	Approved	[302]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[303]

Drug(s) Affected By Aminopeptidase N (ANPEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[238]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[304]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[305]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[306]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[307]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]

Drug(s) Affected By 15-hydroxyprostaglandin dehydrogenase (HPGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[125]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[308]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[308]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[309]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[310]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[311]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[312]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[313]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[314]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[315]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[316]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[201]

Drug(s) Affected By Platelet glycoprotein 4 (CD36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[317]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[318]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[319]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[320]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[321]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[322]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[295]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[323]

Drug(s) Affected By Fumarylacetoacetase (FAH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[148]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]

Drug(s) Affected By Gap junction alpha-1 protein (GJA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[324]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[326]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[324]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[327]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[328]
Griseofulvin	DMK54YG	Onychomycosis	EE12.1	Approved	[329]

Drug(s) Affected By Insulin-like growth factor-binding protein 3 (IGFBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Selenium	DM25CGV	N. A.	N. A.	Approved	[330]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[331]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[332]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[333]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[334]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[335]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[40]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[336]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[337]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[338]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[339]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[340]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[341]

Drug(s) Affected By Fibulin-1 (FBLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[236]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[342]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]

Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[343]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[344]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[345]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[272]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[273]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[346]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[176]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]

Drug(s) Affected By Integrin alpha-6 (ITGA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[347]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[331]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[348]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[349]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[350]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[351]

Drug(s) Affected By Laminin subunit alpha-2 (LAMA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[176]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[176]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[352]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[353]

Drug(s) Affected By Endothelin receptor type B (EDNRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[348]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[354]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[355]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[356]
Fenoterol	DMIP3ZV	Asthma	CA23	Approved	[357]

Drug(s) Affected By Insulin-like growth factor-binding protein 5 (IGFBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[234]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[358]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[354]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[334]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[359]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[360]

Drug(s) Affected By Atypical chemokine receptor 3 (ACKR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[236]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[125]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[361]

Drug(s) Affected By Collagen alpha-5(IV) chain (COL4A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[162]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[362]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[268]

Drug(s) Affected By ER lumen protein-retaining receptor 2 (KDELR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[363]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[114]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[147]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[364]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[365]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[366]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[367]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[368]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[369]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[370]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[371]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[372]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[373]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[374]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[375]

Drug(s) Affected By Pigment epithelium-derived factor (SERPINF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[376]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[376]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]

Drug(s) Affected By Prostaglandin-H2 D-isomerase (PTGDS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[377]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[378]

Drug(s) Affected By 5-hydroxytryptamine receptor 2B (HTR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[40]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[379]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[380]
Bortezomib	DMNO38U	Leukemia		Approved	[153]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[62]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[381]
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[382]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[383]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]

Drug(s) Affected By Glutamate receptor 1 (GRIA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[384]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[385]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[62]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[381]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[198]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[42]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[386]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[387]

Drug(s) Affected By C-X-C motif chemokine 5 (CXCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[258]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[162]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[388]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[251]

Drug(s) Affected By Prostacyclin receptor (PTGIR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Iloprost	DMVPZBE	Pulmonary arterial hypertension	BB01.0	Approved	[389]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[390]
cicaprost	DM7ZJ4H	Discovery agent	N.A.	Investigative	[389]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[303]

Drug(s) Affected By Small ribosomal subunit protein eS10 (RPS10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[391]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[392]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[81]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[136]
Z-Pro-Prolinal	DM43O2U	Discovery agent	N.A.	Investigative	[393]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[394]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[395]

Drug(s) Affected By Microtubule-associated protein 1B (MAP1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[396]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[203]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[326]

Drug(s) Affected By Stromal cell-derived factor 1 (CXCL12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[285]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[397]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[103]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[160]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[398]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[376]

Drug(s) Affected By Transcription factor SOX-9 (SOX9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[399]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[400]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[125]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[401]

Drug(s) Affected By Heat shock 70 kDa protein 13 (HSPA13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[396]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[367]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[203]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[402]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[58]

Drug(s) Affected By DNA polymerase delta subunit 2 (POLD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[348]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[99]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[403]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[99]

Drug(s) Affected By MARCKS-related protein (MARCKSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[367]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[381]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]

Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[404]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[405]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[406]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[407]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[360]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[408]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[409]

Drug(s) Affected By ADP-ribosylation factor-like protein 4D (ARL4D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[410]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[299]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[411]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[412]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]

Drug(s) Affected By Matrix metalloproteinase-14 (MMP14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[413]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[414]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[415]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[416]
Cysteamine	DMSYFM8	Nephropathic cystinosis	5C60	Approved	[417]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[418]

Drug(s) Affected By Matrix metalloproteinase-16 (MMP16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[413]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[125]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[419]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[420]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]

Drug(s) Affected By RNA-binding protein Nova-1 (NOVA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[253]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[421]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[113]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[42]

Drug(s) Affected By Lumican (LUM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[380]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[422]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[122]

Drug(s) Affected By ATP-citrate synthase (ACLY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[317]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[369]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[100]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[423]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[424]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[425]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[317]

Drug(s) Affected By Cadherin-11 (CDH11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[367]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[348]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[426]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[163]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[427]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[428]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[238]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[429]
Selenium	DM25CGV	N. A.	N. A.	Approved	[430]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[338]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[431]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[432]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[433]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]

Drug(s) Affected By Sestrin-3 (SESN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[311]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[203]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[434]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[137]

Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[367]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[435]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[436]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]

Drug(s) Affected By Ras-related protein Rap-1b (RAP1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[162]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[279]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[437]

Drug(s) Affected By 26S proteasome regulatory subunit 10B (PSMC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[438]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[439]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[440]

Drug(s) Affected By Large ribosomal subunit protein eL39 (RPL39)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[441]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[394]

Drug(s) Affected By Contactin-associated protein 1 (CNTNAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[442]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[162]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[117]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[117]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[443]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]

Drug(s) Affected By Fractalkine (CX3CL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[201]
Fructose	DM43AN2	Vomiting	MD90	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[201]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[445]

Drug(s) Affected By Sushi repeat-containing protein SRPX (SRPX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[446]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[100]

Drug(s) Affected By C-C motif chemokine 8 (CCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[447]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[125]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[162]
Bortezomib	DMNO38U	Leukemia		Approved	[448]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[449]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]

Drug(s) Affected By Rho-related GTP-binding protein RhoG (RHOG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[450]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]

Drug(s) Affected By Small EDRK-rich factor 2 (SERF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[451]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[95]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[452]

Drug(s) Affected By Norrin (NDP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[292]
3,4-Dihydroxycinnamic Acid	DMVZL26	Thrombocytopenia	3B64	Phase 4	[453]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[42]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[42]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]

Drug(s) Affected By Angiopoietin-1 receptor (TEK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[454]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[454]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[455]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[456]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[457]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[458]

Drug(s) Affected By Tyrosine-protein kinase BTK (BTK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[459]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[460]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[461]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[300]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[462]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[463]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[361]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PPP2R3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[464]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[279]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[465]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[466]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]

Drug(s) Affected By Early activation antigen CD69 (CD69)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[467]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[141]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[468]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[141]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[361]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[162]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[469]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[470]

Drug(s) Affected By Tight junction protein ZO-1 (TJP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[471]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[367]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[172]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[472]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[473]

Drug(s) Affected By Sperm-associated antigen 1 (SPAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[125]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[152]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[253]

Drug(s) Affected By ATP-binding cassette sub-family C member 8 (ABCC8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[474]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[40]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]
L-leucine	DMQHN7I	Discovery agent	N.A.	Investigative

Drug(s) Affected By Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[475]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[476]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[106]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[363]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[127]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[477]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[478]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[479]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[480]

Drug(s) Affected By Metastasis-associated protein MTA1 (MTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[234]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[467]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[481]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[446]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[450]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]

Drug(s) Affected By Phospholipase D1 (PLD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[482]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[203]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[483]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[148]

Drug(s) Affected By Laminin subunit gamma-2 (LAMC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[212]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[484]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[485]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[485]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[250]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[486]

Drug(s) Affected By Collagen alpha-6(IV) chain (COL4A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[147]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[487]
Arecoline	DMFJZK3	Parkinson disease	8A00.0	Phase 1	[488]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]

Drug(s) Affected By Interleukin-13 receptor subunit alpha-2 (IL13RA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[232]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[162]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[148]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[251]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[489]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[490]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[491]

Drug(s) Affected By ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[492]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[295]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[361]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[85]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase kappa (PTPRK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[494]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[137]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[495]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[496]

Drug(s) Affected By P2Y purinoceptor 14 (P2RY14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[467]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[292]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[467]

Drug(s) Affected By Monocyte to macrophage differentiation factor (MMD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[219]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[100]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[117]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[85]

Drug(s) Affected By TSC22 domain family protein 1 (TSC22D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[497]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[361]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[162]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[85]

Drug(s) Affected By Adipogenesis regulatory factor (ADIRF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[478]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[498]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[62]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[122]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]

Drug(s) Affected By Mitogen-activated protein kinase 6 (MAPK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[62]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[499]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[81]

Drug(s) Affected By Laminin subunit alpha-3 (LAMA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[167]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[105]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[105]

Drug(s) Affected By Centrosomal protein kizuna (KIZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[500]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[163]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[501]

Drug(s) Affected By Carboxypeptidase Z (CPZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[253]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[386]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[123]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[462]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By F-box only protein 46 (FBXO46)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[502]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[124]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[503]

Drug(s) Affected By Plexin domain-containing protein 2 (PLXDC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[380]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[410]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[504]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[279]

Drug(s) Affected By Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase (B3GNT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[505]

Drug(s) Affected By Protein mono-ADP-ribosyltransferase TIPARP (TIPARP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[506]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[125]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[105]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]

Drug(s) Affected By Kinesin-like protein KIF27 (KIF27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[403]

Drug(s) Affected By Osteopetrosis-associated transmembrane protein 1 (OSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[263]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[507]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[253]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[508]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[509]

Drug(s) Affected By Membrane progestin receptor alpha (PAQR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[124]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[510]

Drug(s) Affected By Secreted frizzled-related protein 1 (SFRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[348]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[511]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[360]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[512]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[127]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]

Drug(s) Affected By RB1-inducible coiled-coil protein 1 (RB1CC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[513]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[514]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Bortezomib	DMNO38U	Leukemia		Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[515]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[501]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 1C (PPP1R1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[120]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[516]

Drug(s) Affected By Kelch-like protein 6 (KLHL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[442]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[81]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[517]

Drug(s) Affected By C-type lectin domain family 2 member B (CLEC2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[203]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[518]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[519]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[363]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[120]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[155]

Drug(s) Affected By (3R)-3-hydroxyacyl-CoA dehydrogenase (HSD17B8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[442]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[120]

Drug(s) Affected By Tribbles homolog 2 (TRIB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[520]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[521]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[451]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[87]

Drug(s) Affected By Histone deacetylase 2 (HDAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[522]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[523]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[524]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[525]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[526]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[299]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[134]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[527]

Drug(s) Affected By Type II iodothyronine deiodinase (DIO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[260]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[528]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[529]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[530]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[162]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[529]

Drug(s) Affected By Stathmin-2 (STMN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[117]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[117]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[42]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[123]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[42]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[502]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[531]

Drug(s) Affected By Seipin (BSCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]

Drug(s) Affected By Receptor expression-enhancing protein 6 (REEP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[438]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[163]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[117]

Drug(s) Affected By Mannose-1-phosphate guanyltransferase alpha (GMPPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[412]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[147]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[120]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[76]

Drug(s) Affected By Mastermind-like protein 3 (MAML3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[531]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[532]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[147]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[533]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[361]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[531]

Drug(s) Affected By Translocation protein SEC62 (SEC62)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[361]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[496]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[534]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[422]

Drug(s) Affected By Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[467]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[535]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[152]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[363]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[253]

Drug(s) Affected By C-C motif chemokine 13 (CCL13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[536]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[537]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[100]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[490]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[538]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[490]

Drug(s) Affected By SH3-containing GRB2-like protein 3-interacting protein 1 (SGIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[143]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[123]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[120]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]

Drug(s) Affected By Receptor expression-enhancing protein 2 (REEP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[402]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[253]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[58]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[539]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[303]

Drug(s) Affected By Latexin (LXN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[202]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[125]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[236]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[236]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[540]

Drug(s) Affected By Complement C1q tumor necrosis factor-related protein 6 (C1QTNF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[162]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[117]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[117]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[303]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[541]

Drug(s) Affected By Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[203]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[167]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[380]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[251]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[292]

Drug(s) Affected By E3 ubiquitin-protein ligase SMURF2 (SMURF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[336]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Bortezomib	DMNO38U	Leukemia		Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[95]

Drug(s) Affected By Netrin-4 (NTN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[326]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]

Drug(s) Affected By Endothelial cell-specific molecule 1 (ESM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[542]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[363]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[543]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[544]
PD-0325901	DM27D4J	Breast cancer	2C60-2C65	Phase 2	[545]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[149]

Drug(s) Affected By Exosome complex component RRP46 (EXOSC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[117]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[117]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]

Drug(s) Affected By Protein reprimo (RPRM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[253]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[166]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[42]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[531]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[541]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF146 (RNF146)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[152]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[85]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[546]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[81]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[503]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[447]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[482]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[90]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[331]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[547]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[506]

Drug(s) Affected By CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[279]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]

Drug(s) Affected By Ankyrin repeat domain-containing protein 10 (ANKRD10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[361]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[153]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[485]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[548]

Drug(s) Affected By LIM and cysteine-rich domains protein 1 (LMCD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[380]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]

Drug(s) Affected By Sentrin-specific protease 1 (SENP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[549]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[550]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]

Drug(s) Affected By Phosphatidylethanolamine N-methyltransferase (PEMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[100]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[253]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[88]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[551]

Drug(s) Affected By DnaJ homolog subfamily B member 9 (DNAJB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[447]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[54]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[552]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[447]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[105]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[401]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[531]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[105]

Drug(s) Affected By Alpha-catulin (CTNNAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[217]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[467]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[361]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]

Drug(s) Affected By Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (ST6GALNAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[494]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[198]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[268]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[156]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[66]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[531]

Drug(s) Affected By Polypyrimidine tract-binding protein 2 (PTBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[137]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[464]

Drug(s) Affected By Frizzled-4 (FZD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[202]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[135]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[134]

Drug(s) Affected By Frizzled-10 (FZD10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[232]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[108]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[42]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[553]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[124]

Drug(s) Affected By Lysosomal thioesterase PPT2 (PPT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[554]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[555]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By Sorting nexin-12 (SNX12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[136]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[124]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[556]

Drug(s) Affected By HIG1 domain family member 1A, mitochondrial (HIGD1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[136]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[120]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[123]

Drug(s) Affected By Band 4.1-like protein 3 (EPB41L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[203]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[125]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[557]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[85]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[402]

Drug(s) Affected By Long-chain fatty acid transport protein 5 (SLC27A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[558]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[559]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[560]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[58]

Drug(s) Affected By Axin-2 (AXIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[350]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[561]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[562]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[563]

Drug(s) Affected By Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[446]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[468]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[299]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[463]

Drug(s) Affected By Adhesion G-protein coupled receptor G1 (ADGRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[167]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[564]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[168]

Drug(s) Affected By Calcineurin-binding protein cabin-1 (CABIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[396]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[549]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[521]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[156]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[81]

Drug(s) Affected By SEC23-interacting protein (SEC23IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[81]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[565]

Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[566]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[125]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[567]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[405]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[568]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[569]
Oxymetholone	DMFXUT8	Aplastic anemia	3A70	Approved	[570]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[571]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[572]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[573]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[574]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[575]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[576]
Fructose	DM43AN2	Vomiting	MD90	Approved	[577]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[578]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[579]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[580]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[580]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[266]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[579]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[580]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[581]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[579]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[582]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[579]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[585]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[586]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[587]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[588]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[310]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[589]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[590]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[591]

Drug(s) Affected By Interleukin-1 receptor-associated kinase-like 2 (IRAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[91]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[361]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[100]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[162]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[592]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[592]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[593]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[594]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[595]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[592]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[592]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[592]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[49]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[596]

Drug(s) Affected By T-cell surface glycoprotein CD4 (CD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[240]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[597]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[519]
Rimexolone	DMTAREC	Arthritis	FA20	Approved	[598]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[300]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[597]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[236]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[599]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[260]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[600]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[271]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[601]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[602]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[603]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[604]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[605]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[606]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[607]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[367]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[184]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[608]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[609]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[610]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[218]

Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[611]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[612]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[613]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[614]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[615]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[616]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[617]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[618]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[619]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[260]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[620]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[621]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[429]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[622]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[623]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[622]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[624]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[625]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[626]

Drug(s) Affected By Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[627]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[627]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[627]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[628]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[629]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[611]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[630]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[631]
Selenium	DM25CGV	N. A.	N. A.	Approved	[632]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[633]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[634]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[635]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[636]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[637]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[40]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[260]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[638]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[639]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[640]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[641]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[642]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[213]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[358]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[643]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[608]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[644]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[217]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[645]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]

Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[646]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[234]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[647]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[648]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[649]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[234]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[650]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[651]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[652]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[653]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[654]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[655]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[55]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[656]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[657]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[658]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[659]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[660]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[661]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[662]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[663]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[664]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[665]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[666]

Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[667]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[644]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[668]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[669]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[670]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[671]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[605]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[672]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[673]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[674]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[675]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[676]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[677]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[678]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[679]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[680]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[681]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[682]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[683]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[684]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[272]
Fructose	DM43AN2	Vomiting	MD90	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[685]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[686]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[687]

Drug(s) Affected By Cathelicidin antimicrobial peptide (CAMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[688]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[689]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[690]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[112]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[691]

Drug(s) Affected By Forkhead box protein L2 (FOXL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[692]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[693]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[120]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]

Drug(s) Affected By Neutrophil defensin 1 (DEFA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[694]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[695]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[690]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]

Drug(s) Affected By Neutrophil defensin 3 (DEFA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[696]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[690]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[697]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[260]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[698]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[699]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[90]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[608]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[159]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[634]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[666]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[260]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[638]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[285]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[700]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[607]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[367]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[701]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[623]

Drug(s) Affected By Protein GREB1 (GREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[234]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[702]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[703]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[702]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[704]
Mestranol	DMG3F94	Contraception	QA21	Approved	[702]

Drug(s) Affected By Progesterone-induced-blocking factor 1 (PIBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dydrogesterone	DMAKIDV	Menstrual disorder	GA20.3	Approved	[705]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[690]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[156]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By Interleukin-1 receptor-associated kinase 4 (IRAK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[706]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[690]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[111]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[120]

Drug(s) Affected By Toll-like receptor 7 (TLR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[707]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[708]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[690]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[97]

Drug(s) Affected By Semaphorin-3B (SEMA3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[709]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[710]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[711]

Drug(s) Affected By Semaphorin-3F (SEMA3F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[399]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[84]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[163]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[253]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucocorticoid receptor (NR3C1)	TTYRL6O	GCR_HUMAN	Modulator	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[3]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
(3R)-3-hydroxyacyl-CoA dehydrogenase (HSD17B8)	OTX1DWEF	DHB8_HUMAN	Gene/Protein Processing	[5]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)	OTHF4H9U	DHI2_HUMAN	Gene/Protein Processing	[6]
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Gene/Protein Processing	[5]
17-beta-hydroxysteroid dehydrogenase type 6 (HSD17B6)	OTSB55D2	H17B6_HUMAN	Gene/Protein Processing	[5]
26S proteasome regulatory subunit 10B (PSMC6)	OTG8997V	PRS10_HUMAN	Gene/Protein Processing	[5]
5-hydroxytryptamine receptor 2B (HTR2B)	OTM1AD9J	5HT2B_HUMAN	Gene/Protein Processing	[5]
Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase (B3GNT6)	OTAX8BNJ	B3GN6_HUMAN	Gene/Protein Processing	[5]
Actin, cytoplasmic 1 (ACTB)	OT1MCP2F	ACTB_HUMAN	Gene/Protein Processing	[5]
Actin-binding LIM protein 1 (ABLIM1)	OTHXEK3E	ABLM1_HUMAN	Gene/Protein Processing	[5]
Adhesion G-protein coupled receptor G1 (ADGRG1)	OTQBB8NT	AGRG1_HUMAN	Gene/Protein Processing	[5]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2805).
• [2] The glucocorticoid agonist activities of mifepristone (RU486) and progesterone are dependent on glucocorticoid receptor levels but not on EC50 values. Steroids. 2007 Jun;72(6-7):600-8.
• [3] Evaluation of strategies for the assessment of drug-drug interactions involving cytochrome P450 enzymes. Eur J Drug Metab Pharmacokinet. 2018 Dec;43(6):737-750.
• [4] Comparative analysis of substrate and inhibitor interactions with CYP3A4 and CYP3A5. Xenobiotica. 2006 Apr;36(4):287-99.
• [5] Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
• [6] Effect of the interaction between lipoxygenase pathway and progesterone on the regulation of hydroxysteroid 11-Beta dehydrogenase 2 in cultured human term placental trophoblasts. Biol Reprod. 2008 Mar;78(3):514-20.
• [7] Interaction between the glucocorticoid and erythropoietin receptors in human erythroid cells. Exp Hematol. 2009 May;37(5):559-72.
• [8] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [9] Aldosterone (mineralocorticoid) equivalent to prednisolone (glucocorticoid) in reversing hearing loss in MRL/MpJ-Fas1pr autoimmune mice. Laryngoscope. 2000 Nov;110(11):1902-6.
• [10] Fluticasone furoate nasal spray in allergic rhinitis. Drugs Today (Barc). 2008 Apr;44(4):251-60.
• [11] Cytochromes P450 (CYP) in the Poeciliopsis lucida hepatocellular carcinoma cell line (PLHC-1): dose- and time-dependent glucocorticoid potentiation of CYP1A induction without induction of CYP3A. ArchBiochem Biophys. 1996 May 1;329(1):113-22.
• [12] PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonide. Eur J Pharm Sci. 2009 Mar 2;36(4-5):565-71.
• [13] Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer. 2007 Mar 1;109(5):957-65.
• [14] Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47.
• [15] Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.
• [16] Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone. Drug Metab Dispos. 2013 Feb;41(2):263-9.
• [17] Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
• [18] Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates. Br J Pharmacol. 2012 Apr;165(8):2787-98.
• [19] Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos. 2007 Apr;28(3):151-6.
• [20] The metabolism of zidovudine by human liver microsomes in vitro: formation of 3'-amino-3'-deoxythymidine. Biochem Pharmacol. 1994 Jul 19;48(2):267-76.
• [21] Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
• [22] Drug related genetic polymorphisms affecting adverse reactions to methotrexate, vinblastine, doxorubicin and cisplatin in patients with urothelial cancer. J Urol. 2008 Dec;180(6):2389-95.
• [23] Human prostate CYP3A5: identification of a unique 5'-untranslated sequence and characterization of purified recombinant protein. Biochem Biophys Res Commun. 1999 Jul 14;260(3):676-81.
• [24] Polymorphisms in cytochrome P4503A5 (CYP3A5) may be associated with race and tumor characteristics, but not metabolism and side effects of tamoxifen in breast cancer patients. Cancer Lett. 2005 Jan 10;217(1):61-72.
• [25] Drug Interactions Flockhart Table
• [26] Induction of hepatic CYP2E1 by a subtoxic dose of acetaminophen in rats: increase in dichloromethane metabolism and carboxyhemoglobin elevation. Drug Metab Dispos. 2007 Oct;35(10):1754-8.
• [27] Urinary 6 beta-hydroxycortisol excretion in rheumatoid arthritis. Br J Rheumatol. 1997 Jan;36(1):54-8.
• [28] Clinical pharmacokinetics of imatinib. Clin Pharmacokinet. 2005;44(9):879-94.
• [29] Kinetics and regulation of cytochrome P450-mediated etoposide metabolism. Drug Metab Dispos. 2004 Sep;32(9):993-1000.
• [30] Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil. Drug Metab Dispos. 2005 May;33(5):664-71.
• [31] The relative role of CYP3A4 and CYP3A5 in eplerenone metabolism. Toxicol Lett. 2019 Oct 15;315:9-13.
• [32] Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol. Chem Biol Interact. 2014 May 25;215:62-8.
• [33] Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells. Toxicol Sci. 2006 Jul;92(1):51-60.
• [34] The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis. Antimicrob Agents Chemother. 2004 Sep;48(9):3272-8.
• [35] Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos. 2001 Jan;29(1):30-5.
• [36] Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5591-4.
• [37] Mechanism-based inactivation of CYP3A by HIV protease inhibitors. J Pharmacol Exp Ther. 2005 Feb;312(2):583-91.
• [38] Studies of the toxicological potential of capsinoids, XIII: inhibitory effects of capsaicin and capsinoids on cytochrome P450 3A4 in human liver microsomes. Int J Toxicol. 2010 Mar;29(2 Suppl):22S-6S.
• [39] Investigation of the effects of axitinib on the pharmacokinetics of loperamide and its main metabolite N-demethylated loperamide in rats by UPLC-MS/MS. Chem Biol Interact. 2019 Sep 1;310:108744. doi: 10.1016/j.cbi.2019.108744. Epub 2019 Jul 9.
• [40] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [41] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [42] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [43] Arsenic trioxide inhibits neuroblastoma growth in vivo and promotes apoptotic cell death in vitro. Biochem Biophys Res Commun. 2000 Oct 14;277(1):179-85. doi: 10.1006/bbrc.2000.3651.
• [44] Release and functional role of neuropeptide Y as a sympathetic modulator in human saphenous vein biopsies. Peptides. 2004 Jan;25(1):53-64. doi: 10.1016/j.peptides.2003.11.001.
• [45] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [46] Neuropeptide Y in cortisol-induced hypertension in male volunteers. Clin Exp Pharmacol Physiol. 1994 May;21(5):435-8. doi: 10.1111/j.1440-1681.1994.tb02538.x.
• [47] [Effect of orlistat therapy on carbohydrate, lipid, vitamin and hormone plasma levels in obese subjects]. Pol Arch Med Wewn. 2004 Dec;112(6):1415-23.
• [48] Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. BMC Cancer. 2007 Dec 11;7:223.
• [49] Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor. Drug Metab Dispos. 2005 Jul;33(7):924-9.
• [50] Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways. Pharm Res. 2009 Apr;26(4):872-82.
• [51] Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
• [52] Fetal bovine serum and human constitutive androstane receptor: evidence for activation of the SV23 splice variant by artemisinin, artemether, and arteether in a serum-free cell culture system. Toxicol Appl Pharmacol. 2014 Jun 1;277(2):221-30. doi: 10.1016/j.taap.2014.03.023. Epub 2014 Apr 12.
• [53] Constitutive androstane/active receptor is a target of retinoic acid receptor in humans. Biochem Pharmacol. 2010 Jul 1;80(1):129-35. doi: 10.1016/j.bcp.2010.02.023. Epub 2010 Mar 6.
• [54] Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
• [55] Expression and inducibility of cytochrome P450s (CYP1A1, 2B6, 2E1, 3A4) in human cord blood CD34(+) stem cell-derived differentiating neuronal cells. Toxicol Sci. 2012 Oct;129(2):392-410.
• [56] Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay. Toxicol In Vitro. 2018 Feb;46:335-349. doi: 10.1016/j.tiv.2017.09.014. Epub 2017 Sep 18.
• [57] Teriflunomide is an indirect human constitutive androstane receptor (CAR) activator interacting with epidermal growth factor (EGF) signaling. Front Pharmacol. 2018 Oct 11;9:993.
• [58] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [59] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [60] Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
• [61] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
• [62] 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
• [63] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [64] Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma. Int J Cancer. 2015 May 1;136(9):2055-64.
• [65] Influence of cell cycle on responses of MCF-7 cells to benzo[a]pyrene. BMC Genomics. 2011 Jun 29;12:333.
• [66] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [67] Cultured human peripheral blood mononuclear cells alter their gene expression when challenged with endocrine-disrupting chemicals. Toxicology. 2013 Jan 7;303:17-24.
• [68] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [69] THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
• [70] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
• [71] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [72] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [73] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [74] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [75] Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling. Int J Cancer. 2004 Nov 1;112(2):200-12. doi: 10.1002/ijc.20401.
• [76] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [77] Constitutive gene expression predisposes morphogen-mediated cell fate responses of NT2/D1 and 27X-1 human embryonal carcinoma cells. Stem Cells. 2007 Mar;25(3):771-8. doi: 10.1634/stemcells.2006-0271. Epub 2006 Nov 30.
• [78] Identification of differentially expressed genes in hepatic HepG2 cells treated with acetaminophen using suppression subtractive hybridization. Biol Pharm Bull. 2005 Jul;28(7):1148-53. doi: 10.1248/bpb.28.1148.
• [79] Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
• [80] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [81] Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
• [82] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [83] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [84] Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
• [85] Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
• [86] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [87] Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell. 2004 Mar;15(3):1262-72. doi: 10.1091/mbc.e03-06-0360. Epub 2003 Dec 29.
• [88] Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis. Biol Reprod. 2011 Apr;84(4):801-15.
• [89] Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
• [90] Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
• [91] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [92] Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
• [93] Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
• [94] Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
• [95] Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
• [96] Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
• [97] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [98] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [99] Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
• [100] Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
• [101] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [102] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [103] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [104] Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
• [105] Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
• [106] Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
• [107] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [108] Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
• [109] Role of phenytoin in wound healing: microarray analysis of early transcriptional responses in human dermal fibroblasts. Biochem Biophys Res Commun. 2004 Feb 13;314(3):661-6. doi: 10.1016/j.bbrc.2003.12.146.
• [110] DNA methylation inhibits p53-mediated survivin repression. Oncogene. 2009 May 14;28(19):2046-50. doi: 10.1038/onc.2009.62. Epub 2009 Apr 13.
• [111] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
• [112] Characterizing the genetic basis for nicotine induced cancer development: a transcriptome sequencing study. PLoS One. 2013 Jun 18;8(6):e67252.
• [113] Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
• [114] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
• [115] Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
• [116] Distinctive profiles of gene expression in the human nucleus accumbens associated with cocaine and heroin abuse. Neuropsychopharmacology. 2006 Oct;31(10):2304-12. doi: 10.1038/sj.npp.1301089. Epub 2006 May 3.
• [117] Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
• [118] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [119] Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse. Pharmacogenomics J. 2003;3(1):27-40.
• [120] Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
• [121] Gene expression profiling of human peri-implantation endometria between natural and stimulated cycles. Fertil Steril. 2008 Dec;90(6):2152-64.
• [122] Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod. 2011 Jul;26(7):1813-25.
• [123] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
• [124] Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
• [125] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [126] Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
• [127] Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
• [128] Apoptotic action of peroxisome proliferator-activated receptor-gamma activation in human non small-cell lung cancer is mediated via proline oxidase-induced reactive oxygen species formation. Mol Pharmacol. 2007 Sep;72(3):674-85.
• [129] Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
• [130] The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis. Ann Rheum Dis. 2015 Jun;74(6):1311-6. doi: 10.1136/annrheumdis-2014-206028. Epub 2014 Nov 14.
• [131] Inhibition of Super-Enhancer Activity in Autoinflammatory Site-Derived T Cells Reduces Disease-Associated Gene Expression. Cell Rep. 2015 Sep 29;12(12):1986-96. doi: 10.1016/j.celrep.2015.08.046. Epub 2015 Sep 17.
• [132] KAT5 (Tip60) is a potential therapeutic target in malignant pleural mesothelioma. Int J Oncol. 2016 Mar;48(3):1290-6. doi: 10.3892/ijo.2016.3335. Epub 2016 Jan 13.
• [133] Cancer-related proteins in serum are altered in workers occupationally exposed to polycyclic aromatic hydrocarbons: a cross-sectional study. Carcinogenesis. 2019 Jul 6;40(6):771-781. doi: 10.1093/carcin/bgz022.
• [134] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [135] Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
• [136] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [137] Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
• [138] A genomic approach to predict synergistic combinations for breast cancer treatment. Pharmacogenomics J. 2013 Feb;13(1):94-104. doi: 10.1038/tpj.2011.48. Epub 2011 Nov 15.
• [139] Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
• [140] Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study. Environ Health Perspect. 2015 May;123(5):458-66. doi: 10.1289/ehp.1408775. Epub 2015 Jan 13.
• [141] Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
• [142] Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
• [143] Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
• [144] Selective transport of monoamine neurotransmitters by human plasma membrane monoamine transporter and organic cation transporter 3. J Pharmacol Exp Ther. 2010 Dec;335(3):743-53. doi: 10.1124/jpet.110.170142. Epub 2010 Sep 21.
• [145] Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
• [146] Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. Br J Pharmacol. 2002 Jul;136(6):829-36.
• [147] LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
• [148] CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
• [149] CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
• [150] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [151] Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
• [152] Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
• [153] The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
• [154] Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci. 2006 Jan;97(1):64-71.
• [155] Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
• [156] Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
• [157] The donor substrate specificity of the human beta 1,3-glucuronosyltransferase I toward UDP-glucuronic acid is determined by two crucial histidine and arginine residues. J Biol Chem. 2002 Jul 12;277(28):25439-45. doi: 10.1074/jbc.M201912200. Epub 2002 May 1.
• [158] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [159] Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
• [160] Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
• [161] The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
• [162] Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
• [163] Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
• [164] Expression of copper-responsive genes in HepG2 cells. Mol Cell Biochem. 2005 Nov;279(1-2):141-7.
• [165] Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes. Toxicol In Vitro. 2021 Jun;73:105107. doi: 10.1016/j.tiv.2021.105107. Epub 2021 Feb 3.
• [166] Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
• [167] Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
• [168] Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia. J Exp Med. 2010 Apr 12;207(4):731-50. doi: 10.1084/jem.20091488. Epub 2010 Apr 5.
• [169] Effect of spironolactone on impaired fibrinolysis of hypertensive patients. Kidney Blood Press Res. 2002;25(4):260-4. doi: 10.1159/000066348.
• [170] Involvement of retinoic acid receptor alpha in the stimulation of tissue-type plasminogen-activator gene expression in human endothelial cells. Eur J Biochem. 1995 Sep 1;232(2):425-32.
• [171] Relation between long-term steroid treatment after heart transplantation, hypofibrinolysis and myocardial microthrombi generation. J Heart Lung Transplant. 1999 Jul;18(7):693-700. doi: 10.1016/s1053-2498(99)00021-2.
• [172] Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
• [173] Simvastatin increases fibrinolytic activity in human peritoneal mesothelial cells independent of cholesterol lowering. Kidney Int. 2002 Nov;62(5):1611-9. doi: 10.1046/j.1523-1755.2002.00601.x.
• [174] Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans: implication for the adverse effects of cyclooxygenase-2 inhibitors. Clin Pharmacol Ther. 2006 Apr;79(4):303-15. doi: 10.1016/j.clpt.2005.12.306.
• [175] Non-nutritional sweeteners effects on endothelial vascular function. Toxicol In Vitro. 2020 Feb;62:104694. doi: 10.1016/j.tiv.2019.104694. Epub 2019 Oct 23.
• [176] Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
• [177] Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-kappaB activity. Toxicol Sci. 2002 Apr;66(2):233-43. doi: 10.1093/toxsci/66.2.233.
• [178] Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
• [179] Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
• [180] ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2007 May;6(5):1579-87. doi: 10.1158/1535-7163.MCT-06-0814.
• [181] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [182] Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
• [183] Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
• [184] Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
• [185] Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. Cancer Res. 2002 Nov 1;62(21):6006-10.
• [186] Verapamil-induced hyperprolactinemia complicated by a pituitary incidentaloma. Ann Pharmacother. 1995 Oct;29(10):999-1001. doi: 10.1177/106002809502901009.
• [187] [Impotence and gynecomastia secondary to hyperprolactinemia induced by ranitidine]. Therapie. 1994 Jul-Aug;49(4):361-2.
• [188] Differential effects of estrogen receptor antagonists on pituitary lactotroph proliferation and prolactin release. Mol Cell Endocrinol. 2005 Jul 15;239(1-2):27-36. doi: 10.1016/j.mce.2005.04.008.
• [189] Cholinergic modulation of the cerebral metabolic response to citalopram in Alzheimer's disease. Brain. 2009 Feb;132(Pt 2):392-401. doi: 10.1093/brain/awn326. Epub 2009 Jan 19.
• [190] The effect of thioridazine on prolactinoma growth in a schizophrenic man: case report. Gen Hosp Psychiatry. 1985 Oct;7(4):364-6. doi: 10.1016/0163-8343(85)90053-2.
• [191] Influence of naloxone on muscle sympathetic nerve activity, systemic and calf haemodynamics and ambulatory blood pressure after exercise in mild essential hypertension. J Hypertens. 1995 Apr;13(4):447-61.
• [192] The efficacy, safety, and tolerability of aripiprazole for the treatment of schizoaffective disorder: results from a pooled analysis of a sub-population of subjects from two randomized, double-blind, placebo-controlled, pivotal trials. J Affect Disord. 2009 May;115(1-2):18-26. doi: 10.1016/j.jad.2008.12.017. Epub 2009 Feb 23.
• [193] Serum prolactin levels among outpatients with major depressive disorder during the acute phase of treatment with fluoxetine. J Clin Psychiatry. 2006 Jun;67(6):952-7. doi: 10.4088/jcp.v67n0612.
• [194] Massive breast enlargement in a patient receiving D-penicillamine for systemic sclerosis. J Rheumatol. 1985 Oct;12(5):990-1.
• [195] Glucosamine decreases expression of anabolic and catabolic genes in human osteoarthritic cartilage explants. Osteoarthritis Cartilage. 2006 Mar;14(3):250-7. doi: 10.1016/j.joca.2005.10.001. Epub 2005 Nov 18.
• [196] Parathyroid hormone 1-34 reduces dexamethasone-induced terminal differentiation in human articular chondrocytes. Toxicology. 2016 Aug 10;368-369:116-128.
• [197] Evaluation of developmental toxicity using undifferentiated human embryonic stem cells. J Appl Toxicol. 2015 Feb;35(2):205-18.
• [198] RNA sequence analysis of inducible pluripotent stem cell-derived cardiomyocytes reveals altered expression of DNA damage and cell cycle genes in response to doxorubicin. Toxicol Appl Pharmacol. 2018 Oct 1;356:44-53.
• [199] Induction of the endoplasmic reticulum stress protein GADD153/CHOP by capsaicin in prostate PC-3 cells: a microarray study. Biochem Biophys Res Commun. 2008 Aug 8;372(4):785-91.
• [200] Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells. Proteomics. 2004 Jul;4(7):2160-74.
• [201] Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
• [202] Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
• [203] Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
• [204] Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
• [205] Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells. Biol Pharm Bull. 2007 Feb;30(2):247-53. doi: 10.1248/bpb.30.247.
• [206] Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells. Pharm Res. 2010 Oct;27(10):2162-74. doi: 10.1007/s11095-010-0219-2. Epub 2010 Jul 29.
• [207] Association of cell cycle arrest with anticancer drug-induced epithelial-mesenchymal transition in alveolar epithelial cells. Toxicology. 2019 Aug 1;424:152231. doi: 10.1016/j.tox.2019.06.002. Epub 2019 Jun 4.
• [208] Simvastatin inhibits tissue factor and plasminogen activator inhibitor-1 secretion by peripheral blood mononuclear cells in patients with primary nephrotic syndrome. Eur J Med Res. 2007 May 29;12(5):216-21.
• [209] Polyphenols downregulate PAI-1 gene expression in cultured human coronary artery endothelial cells: molecular contributor to cardiovascular protection. Thromb Res. 2007;121(1):59-65. doi: 10.1016/j.thromres.2007.02.001. Epub 2007 Mar 26.
• [210] Troglitazone reduces plasminogen activator inhibitor-1 expression and secretion in cultured human adipocytes. Diabetologia. 2000 Mar;43(3):377-83. doi: 10.1007/s001250050057.
• [211] Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
• [212] Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
• [213] G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J Biol Chem. 1993 Apr 15;268(11):8298-308.
• [214] mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
• [215] Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
• [216] Differential gene expression of sulindac-treated human breast epithelial cells. Int J Oncol. 2005 Dec;27(6):1727-36.
• [217] Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
• [218] Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
• [219] Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
• [220] Retinoic acid and hydroquinone induce inverse expression patterns on cornified envelope-associated proteins: implication in skin irritation. J Dermatol Sci. 2014 Nov;76(2):112-9. doi: 10.1016/j.jdermsci.2014.08.003. Epub 2014 Aug 26.
• [221] Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
• [222] Extracellular ATP drives breast cancer cell migration and metastasis via S100A4 production by cancer cells and fibroblasts. Cancer Lett. 2018 Aug 28;430:1-10. doi: 10.1016/j.canlet.2018.04.043. Epub 2018 May 5.
• [223] [The discovery of an antiparkinsonian drug, zonisamide]. Rinsho Shinkeigaku. 2010 Feb;50(2):67-73. doi: 10.5692/clinicalneurol.50.67.
• [224] A not cytotoxic nickel concentration alters the expression of neuronal differentiation markers in NT2 cells. Neurotoxicology. 2015 Mar;47:47-53. doi: 10.1016/j.neuro.2015.01.001. Epub 2015 Jan 19.
• [225] Lovastatin induces neuronal differentiation and apoptosis of embryonal carcinoma and neuroblastoma cells: enhanced differentiation and apoptosis in combination with dbcAMP. Mol Cell Biochem. 2010 Dec;345(1-2):1-11. doi: 10.1007/s11010-010-0553-z. Epub 2010 Aug 9.
• [226] Effects of all-trans and 9-cis retinoic acid on differentiating human neural stem cells in vitro. Toxicology. 2023 Mar 15;487:153461. doi: 10.1016/j.tox.2023.153461. Epub 2023 Feb 16.
• [227] Immunohistochemical investigation of dopaminergic terminal markers and caspase-3 activation in the striatum of human methamphetamine users. Int J Legal Med. 2007 May;121(3):163-8. doi: 10.1007/s00414-006-0087-9. Epub 2006 Apr 19.
• [228] A DNA methyltransferase inhibitor, 5-aza-2'-deoxycytidine, exacerbates neurotoxicity and upregulates Parkinson's disease-related genes in dopaminergic neurons. CNS Neurosci Ther. 2013 Mar;19(3):183-90. doi: 10.1111/cns.12059.
• [229] Comparing the dopaminergic neurotoxic effects of benzylpiperazine and benzoylpiperazine. Toxicol Mech Methods. 2018 Mar;28(3):177-186. doi: 10.1080/15376516.2017.1376024. Epub 2017 Sep 28.
• [230] Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
• [231] p21(WAF1/cip1) is an important determinant of intestinal cell response to sulindac in vitro and in vivo. Cancer Res. 2001 Aug 15;61(16):6297-302.
• [232] Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
• [233] Folic acid induces cell type-specific changes in the transcriptome of breast cancer cell lines: a proof-of-concept study. J Nutr Sci. 2016 Apr 26;5:e17. doi: 10.1017/jns.2016.8. eCollection 2016.
• [234] Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
• [235] Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
• [236] Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
• [237] Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
• [238] Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
• [239] Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin-1beta in human tendon-derived cells. A potential mechanism of fluoroquinolone-induced tendinopathy. Arthritis Rheum. 2002 Nov;46(11):3034-40. doi: 10.1002/art.10617.
• [240] Reduction of synovial sublining layer inflammation and proinflammatory cytokine expression in psoriatic arthritis treated with methotrexate. Arthritis Rheum. 2004 Oct;50(10):3286-95. doi: 10.1002/art.20518.
• [241] Quercetin inhibits IL-1-induced proliferation and production of MMPs, COX-2, and PGE2 by rheumatoid synovial fibroblast. Inflammation. 2012 Aug;35(4):1585-94. doi: 10.1007/s10753-012-9473-2.
• [242] Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance. Int J Cancer. 2002 Feb 10;97(5):700-5.
• [243] Human glutathione S-transferase A (GSTA) family genes are regulated by steroidogenic factor 1 (SF-1) and are involved in steroidogenesis. FASEB J. 2013 Aug;27(8):3198-208. doi: 10.1096/fj.12-222745. Epub 2013 May 6.
• [244] Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa. Br J Clin Pharmacol. 2009 Jan;67(1):50-60. doi: 10.1111/j.1365-2125.2008.03321.x. Epub 2008 Nov 17.
• [245] Effects of phenytoin on glutathione status and oxidative stress biomarker gene mRNA levels in cultured precision human liver slices. Toxicol Sci. 2001 Jan;59(1):118-26.
• [246] Acetaminophen-induced hepatocyte injury: C2-ceramide and oltipraz intervention, hepatocyte nuclear factor 1 and glutathione S-transferase A1 changes. J Appl Toxicol. 2019 Dec;39(12):1640-1650. doi: 10.1002/jat.3881. Epub 2019 Aug 6.
• [247] Antineoplastic drug sensitivity of human MCF-7 breast cancer cells stably transfected with a human alpha class glutathione S-transferase gene. Cancer Res. 1991 Jan 15;51(2):587-94.
• [248] Establishment of cisplatin-resistant ovarian yolk sac tumor cells and investigation of the mechanism of cisplatin resistance using this cell line. Gynecol Obstet Invest. 2011;71(2):104-11. doi: 10.1159/000320744. Epub 2010 Dec 9.
• [249] Overexpression of glutathione S-transferase A1-1 in ECV 304 cells protects against busulfan mediated G2-arrest and induces tissue factor expression. Br J Pharmacol. 2002 Dec;137(7):1100-6. doi: 10.1038/sj.bjp.0704972.
• [250] Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
• [251] Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
• [252] Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells. Toxicol Appl Pharmacol. 2017 Sep 15;331:154-163.
• [253] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [254] Nobiletin, a citrus flavonoid, down-regulates matrix metalloproteinase-7 (matrilysin) expression in HT-29 human colorectal cancer cells. Biosci Biotechnol Biochem. 2005 Feb;69(2):307-14. doi: 10.1271/bbb.69.307.
• [255] Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
• [256] The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
• [257] Effect of mood stabilizers on gene expression in lymphoblastoid cells. J Neural Transm (Vienna). 2010 Feb;117(2):155-64.
• [258] Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses. Immunology. 2007 Jun;121(2):266-75. doi: 10.1111/j.1365-2567.2007.02574.x. Epub 2007 Mar 7.
• [259] AMPK-dependent signaling modulates the suppression of invasion and migration by fenofibrate in CAL 27 oral cancer cells through NF-B pathway. Environ Toxicol. 2016 Jul;31(7):866-76. doi: 10.1002/tox.22097. Epub 2014 Dec 24.
• [260] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
• [261] Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
• [262] Zinc induces chemokine and inflammatory cytokine release from human promonocytes. J Hazard Mater. 2011 Nov 30;196:335-41. doi: 10.1016/j.jhazmat.2011.09.035. Epub 2011 Sep 19.
• [263] Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
• [264] Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
• [265] A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3378-83.
• [266] Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
• [267] Human drug metabolism genes in parathion-and estrogen-treated breast cells. Int J Mol Med. 2007 Dec;20(6):875-81.
• [268] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
• [269] Glutathione-related enzymes contribute to resistance of tumor cells and low toxicity in normal organs to artesunate. In Vivo. 2005 Jan-Feb;19(1):225-32.
• [270] Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
• [271] Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
• [272] Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
• [273] D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
• [274] Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
• [275] Identification of human cell responses to benzene and benzene metabolites. Genomics. 2007 Sep;90(3):324-33.
• [276] Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents. Leuk Res. 2010 Jul;34(7):917-24. doi: 10.1016/j.leukres.2009.12.002. Epub 2010 Feb 8.
• [277] Synthesis and preliminary characterization of a novel antiarrhythmic compound (KB130015) with an improved toxicity profile compared with amiodarone. J Med Chem. 2002 Jan 31;45(3):623-30. doi: 10.1021/jm001126+.
• [278] Changes in gene expression and assessment of DNA methylation in primary human hepatocytes and HepG2 cells exposed to the environmental contaminants-Hexabromocyclododecane and 17-beta oestradiol. Toxicology. 2009 Feb 27;256(3):143-51. doi: 10.1016/j.tox.2008.10.017. Epub 2008 Nov 5.
• [279] Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
• [280] A Possible Novel Mechanism of Action of Genistein and Daidzein for Activating Thyroid Hormone Receptor-Mediated Transcription. Toxicol Sci. 2018 Aug 1;164(2):417-427. doi: 10.1093/toxsci/kfy097.
• [281] Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. J Med Chem. 2002 Jul 18;45(15):3310-20. doi: 10.1021/jm0201013.
• [282] Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
• [283] Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nat Commun. 2018 Aug 9;9(1):3069. doi: 10.1038/s41467-018-05402-2.
• [284] Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain Res. 2008 Jan 29;1191:1-11.
• [285] Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
• [286] Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling. Free Radic Biol Med. 2012 Jul 1;53(1):44-50. doi: 10.1016/j.freeradbiomed.2012.04.031. Epub 2012 May 9.
• [287] Nitric oxide causes anoikis through attenuation of E-cadherin and activation of caspase-3 in human gastric carcinoma AZ-521 cells infected with Mycoplasma hyorhinis. J Vet Med Sci. 2010 Jul;72(7):869-74.
• [288] Induced differentiation in HT29, a human colon adenocarcinoma cell line. J Cell Sci. 1999 Aug;112 ( Pt 16):2657-66. doi: 10.1242/jcs.112.16.2657.
• [289] Antitumoral activity of liraglutide, a new DNMT inhibitor in breast cancer cells in vitro and in vivo. Chem Biol Interact. 2021 Nov 1;349:109641. doi: 10.1016/j.cbi.2021.109641. Epub 2021 Sep 14.
• [290] Troglitazone increases expression of E-cadherin and claudin 4 in human pancreatic cancer cells. Biochem Biophys Res Commun. 2009 Mar 13;380(3):614-9. doi: 10.1016/j.bbrc.2009.01.134. Epub 2009 Jan 27.
• [291] Regulation of epithelial cell morphology and functions approaching to more in vivo-like by modifying polyethylene glycol on polysulfone membranes. PLoS One. 2012;7(4):e36110.
• [292] Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
• [293] Differentiation-specific factors modulate epidermal CYP1-4 gene expression in human skin in response to retinoic acid and classic aryl hydrocarbon receptor ligands. J Pharmacol Exp Ther. 2006 Dec;319(3):1162-71.
• [294] Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor. J Steroid Biochem Mol Biol. 2016 Oct;163:77-87.
• [295] Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
• [296] Triclosan treatment decreased the antitumor effect of sorafenib on hepatocellular carcinoma cells. Onco Targets Ther. 2018 May 18;11:2945-2954.
• [297] A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer. Nat Genet. 2015 Sep;47(9):1079-84. doi: 10.1038/ng.3374. Epub 2015 Aug 3.
• [298] Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in Caco-2 cells treated with ezetimibe. J Nutr. 2005 Oct;135(10):2305-12. doi: 10.1093/jn/135.10.2305.
• [299] Gene induction and apoptosis in human hepatocellular carci-noma cells SMMC-7721 exposed to 5-aza-2'-deoxycytidine. Chin Med J (Engl). 2007 Sep 20;120(18):1626-31.
• [300] Effects of tobacco compounds on gene expression in fetal lung fibroblasts. Environ Toxicol. 2008 Aug;23(4):423-34.
• [301] Breast cancer progression in MCF10A series of cell lines is associated with alterations in retinoic acid and retinoid X receptors and with differential response to retinoids. Int J Oncol. 2004 Oct;25(4):961-71.
• [302] Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
• [303] Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
• [304] Enhancement of methotrexate nephrotoxicity after cisplatin therapy. Cancer. 1986 Dec 15;58(12):2617-21. doi: 10.1002/1097-0142(19861215)58:12<2617::aid-cncr2820581211>3.0.co;2-b.
• [305] Detection of gene expression alteration of myeloma cells treated with arsenic trioxide. Zhonghua Xue Ye Xue Za Zhi. 2005 Apr;26(4):209-13.
• [306] Aspirin inhibits thrombin action on endothelial cells via up-regulation of aminopeptidase N/CD13 expression. Atherosclerosis. 2005 Nov;183(1):49-55.
• [307] Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.
• [308] 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells. Arch Biochem Biophys. 2009 Jul 15;487(2):139-45. doi: 10.1016/j.abb.2009.05.017. Epub 2009 Jun 6.
• [309] Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes. Arch Toxicol. 2018 Jan;92(1):371-381.
• [310] Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
• [311] Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
• [312] Enhanced cytotoxicity of bioreductive antitumor agents with dimethyl fumarate in human glioblastoma cells. Anticancer Drugs. 2005 Feb;16(2):167-74.
• [313] Growth-suppressive effect of non-steroidal anti-inflammatory drugs on 11 colon-cancer cell lines and fluorescence differential display of genes whose expression is influenced by sulindac. Int J Cancer. 2000 Dec 15;88(6):873-80. doi: 10.1002/1097-0215(20001215)88:6<873::aid-ijc6>3.0.co;2-b.
• [314] Simvastatin protects dopaminergic neurons against MPP+-induced oxidative stress and regulates the endogenous anti-oxidant system through ERK. Cell Physiol Biochem. 2018;51(4):1957-1968.
• [315] P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
• [316] Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin. Toxicol Lett. 2001 Feb 3;119(1):49-57.
• [317] Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
• [318] Editor's Highlight: Mechanistic Toxicity Tests Based on an Adverse Outcome Pathway Network for Hepatic Steatosis. Toxicol Sci. 2017 Sep 1;159(1):159-169. doi: 10.1093/toxsci/kfx121.
• [319] Lack of uniform platelet activation in patients after ischemic stroke and choice of antiplatelet therapy. Thromb Res. 2004;113(3-4):197-204. doi: 10.1016/j.thromres.2004.03.002.
• [320] Effect of the Catechol-O-Methyltransferase Inhibitors Tolcapone and Entacapone on Fatty Acid Metabolism in HepaRG Cells. Toxicol Sci. 2018 Aug 1;164(2):477-488.
• [321] Regulation of CD36 expression in human melanoma cells. Adv Exp Med Biol. 2002;507:337-42. doi: 10.1007/978-1-4615-0193-0_52.
• [322] Comparative study of the effects of ziram and disulfiram on human monocyte-derived macrophage functions and polarization: involvement of zinc. Cell Biol Toxicol. 2021 Jun;37(3):379-400. doi: 10.1007/s10565-020-09540-6. Epub 2020 Jul 25.
• [323] Magnitude and time course of platelet inhibition with Aggrenox and Aspirin in patients after ischemic stroke: the AGgrenox versus Aspirin Therapy Evaluation (AGATE) trial. Eur J Pharmacol. 2004 Sep 24;499(3):315-24. doi: 10.1016/j.ejphar.2004.07.114.
• [324] Inhibition of estrogen receptor reduces connexin 43 expression in breast cancers. Toxicol Appl Pharmacol. 2018 Jan 1;338:182-190. doi: 10.1016/j.taap.2017.11.020. Epub 2017 Nov 24.
• [325] Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4578-83.
• [326] Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J Nutr Biochem. 2007 Aug;18(8):541-52. doi: 10.1016/j.jnutbio.2006.11.002. Epub 2007 Feb 22.
• [327] Reduced expression of endothelial connexins 43 and 37 in hypertensive rats is rectified after 7-day carvedilol treatment. Am J Hypertens. 2006 Feb;19(2):129-35. doi: 10.1016/j.amjhyper.2005.08.020.
• [328] Role of connexin 43 in cadmium-induced proliferation of human prostate epithelial cells. J Appl Toxicol. 2017 Aug;37(8):933-942. doi: 10.1002/jat.3441. Epub 2017 Feb 8.
• [329] The anti-mitotic drug griseofulvin induces apoptosis of human germ cell tumor cells through a connexin 43-dependent molecular mechanism. Apoptosis. 2013 Apr;18(4):480-91. doi: 10.1007/s10495-012-0800-8.
• [330] Selenium is critical for cancer-signaling gene expression but not cell proliferation in human colon Caco-2 cells. Biofactors. 2007;31(3-4):155-64. doi: 10.1002/biof.5520310302.
• [331] Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
• [332] Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Mol Cell Biochem. 2010 Nov;344(1-2):173-84. doi: 10.1007/s11010-010-0540-4. Epub 2010 Jul 25.
• [333] Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
• [334] Curcumin reduces the expression of survivin, leading to enhancement of arsenic trioxide-induced apoptosis in myelodysplastic syndrome and leukemia stem-like cells. Oncol Rep. 2016 Sep;36(3):1233-42. doi: 10.3892/or.2016.4944. Epub 2016 Jul 15.
• [335] DHT and testosterone, but not DHEA or E2, differentially modulate IGF-I, IGFBP-2, and IGFBP-3 in human prostatic stromal cells. Am J Physiol Endocrinol Metab. 2006 May;290(5):E952-60. doi: 10.1152/ajpendo.00451.2005. Epub 2005 Dec 20.
• [336] Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
• [337] Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation. J Biol Chem. 2005 Jan 28;280(4):2912-23. doi: 10.1074/jbc.M409524200. Epub 2004 Nov 17.
• [338] Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
• [339] Suppression of mammary carcinoma growth by retinoic acid: proapoptotic genes are targets for retinoic acid receptor and cellular retinoic acid-binding protein II signaling. Cancer Res. 2005 Sep 15;65(18):8193-9. doi: 10.1158/0008-5472.CAN-05-1177.
• [340] Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
• [341] Hydroquinone Exposure Worsens Rheumatoid Arthritis through the Activation of the Aryl Hydrocarbon Receptor and Interleukin-17 Pathways. Antioxidants (Basel). 2021 Jun 7;10(6):929. doi: 10.3390/antiox10060929.
• [342] Synergistic effects of arsenic trioxide combined with ascorbic acid in human osteosarcoma MG-63 cells: a systems biology analysis. Eur Rev Med Pharmacol Sci. 2014;18(24):3877-88.
• [343] Acetaminophen selectively suppresses peripheral prostaglandin E2 release and increases COX-2 gene expression in a clinical model of acute inflammation. Pain. 2007 Jun;129(3):279-86.
• [344] Mitochondrial involvement in schizophrenia and other functional psychoses. Neurochem Res. 1996 Sep;21(9):995-1004.
• [345] Quercetin reduces oxidative damage induced by paraquat via modulating expression of antioxidant genes in A549 cells. J Appl Toxicol. 2013 Dec;33(12):1460-7. doi: 10.1002/jat.2812. Epub 2012 Sep 20.
• [346] The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model. Anesth Analg. 2008 Jan;106(1):321-7, table of contents.
• [347] Patterns of some extracellular matrix gene expression are similar in cells from cleft lip-palate patients and in human palatal fibroblasts exposed to diazepam in culture. Toxicology. 2009 Mar 4;257(1-2):10-6. doi: 10.1016/j.tox.2008.12.002. Epub 2008 Dec 9.
• [348] Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
• [349] Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
• [350] A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
• [351] Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells. Carcinogenesis. 2006 May;27(5):916-24. doi: 10.1093/carcin/bgi312. Epub 2005 Dec 16.
• [352] Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer. Chem Res Toxicol. 2015 Jun 15;28(6):1144-55. doi: 10.1021/tx500393y. Epub 2015 Jun 3.
• [353] Microarray-based detection and expression analysis of extracellular matrix proteins in drug?resistant ovarian cancer cell lines. Oncol Rep. 2014 Nov;32(5):1981-90. doi: 10.3892/or.2014.3468. Epub 2014 Sep 9.
• [354] Effect of nephrotoxicants and hepatotoxicants on gene expression profile in human peripheral blood mononuclear cells. Biochem Biophys Res Commun. 2010 Oct 15;401(2):245-50. doi: 10.1016/j.bbrc.2010.09.039. Epub 2010 Sep 16.
• [355] Cardiac toxicity from ethanol exposure in human-induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci. 2019 May 1;169(1):280-292.
• [356] Rosiglitazone attenuates endothelin-1-induced vasoconstriction by upregulating endothelial expression of endothelin B receptor. Hypertension. 2010 Jul;56(1):129-35. doi: 10.1161/HYPERTENSIONAHA.110.150375. Epub 2010 Jun 1.
• [357] beta2-Adrenoceptor agonist modulates endothelin-1 receptors in human isolated bronchi. Am J Respir Cell Mol Biol. 2006 Apr;34(4):410-6. doi: 10.1165/rcmb.2005-0091OC. Epub 2005 Dec 9.
• [358] Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
• [359] JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
• [360] Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
• [361] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [362] Pretreatment of 3-MA prevents doxorubicin-induced cardiotoxicity through inhibition of autophagy initiation. Toxicology. 2023 May 15;490:153512. doi: 10.1016/j.tox.2023.153512. Epub 2023 Apr 14.
• [363] Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
• [364] Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
• [365] Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis. Oncogene. 2010 Mar 4;29(9):1329-38. doi: 10.1038/onc.2009.425. Epub 2009 Nov 30.
• [366] Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
• [367] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
• [368] Sulindac suppresses beta-catenin expression in human cancer cells. Eur J Pharmacol. 2008 Mar 31;583(1):26-31. doi: 10.1016/j.ejphar.2007.12.034. Epub 2008 Feb 5.
• [369] Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
• [370] Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation. Mol Cell Endocrinol. 2012 Jan 2;348(1):260-9. doi: 10.1016/j.mce.2011.09.002. Epub 2011 Sep 6.
• [371] Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib. Leuk Res. 2008 Nov;32(11):1674-83. doi: 10.1016/j.leukres.2008.03.039. Epub 2008 May 15.
• [372] Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene. 2006 Oct 19;25(49):6447-56. doi: 10.1038/sj.onc.1209658. Epub 2006 Jul 31.
• [373] Benzene metabolite hydroquinone induces apoptosis of bone marrow mononuclear cells through inhibition of -catenin signaling. Toxicol In Vitro. 2018 Feb;46:361-369. doi: 10.1016/j.tiv.2017.08.018. Epub 2017 Sep 5.
• [374] Anti-androgen 2-hydroxyflutamide modulates cadherin, catenin and androgen receptor phosphorylation in androgen-sensitive LNCaP and androgen-independent PC3 prostate cancer cell lines acting via PI3K/Akt and MAPK/ERK1/2 pathways. Toxicol In Vitro. 2017 Apr;40:324-335. doi: 10.1016/j.tiv.2017.01.019. Epub 2017 Feb 2.
• [375] Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia. Clin Cancer Res. 2017 Feb 1;23(3):789-803. doi: 10.1158/1078-0432.CCR-16-0226. Epub 2016 Aug 4.
• [376] Sevoflurane but not propofol enhances ovarian cancer cell biology through regulating cellular metabolic and signaling mechanisms. Cell Biol Toxicol. 2023 Aug;39(4):1395-1411. doi: 10.1007/s10565-022-09766-6. Epub 2022 Oct 8.
• [377] Comparative ligand-binding analysis of ten human lipocalins. Biochim Biophys Acta. 2006 Feb;1764(2):161-73. doi: 10.1016/j.bbapap.2005.12.006. Epub 2006 Jan 6.
• [378] Prevention of paraquat-induced apoptosis in human neuronal SH-SY5Y cells by lipocalin-type prostaglandin D synthase. J Neurochem. 2012 Jan;120(2):279-91. doi: 10.1111/j.1471-4159.2011.07570.x. Epub 2011 Nov 24.
• [379] Evaluation of first generation synthetic cannabinoids on binding at non-cannabinoid receptors and in a battery of in?vivo assays in mice. Neuropharmacology. 2016 Nov;110(Pt A):143-153. doi: 10.1016/j.neuropharm.2016.07.016. Epub 2016 Jul 20.
• [380] Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
• [381] Effects of progesterone treatment on expression of genes involved in uterine quiescence. Reprod Sci. 2011 Aug;18(8):781-97.
• [382] Serotonin 5-HT(2B) receptor loss of function mutation in a patient with fenfluramine-associated primary pulmonary hypertension. Cardiovasc Res. 2003 Dec 1;60(3):518-28. doi: 10.1016/j.cardiores.2003.09.015.
• [383] Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. doi: 10.1002/cam4.1179. Epub 2017 Sep 27.
• [384] Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
• [385] THC Treatment Alters Glutamate Receptor Gene Expression in Human Stem Cell-Derived Neurons. Mol Neuropsychiatry. 2017 Nov;3(2):73-84. doi: 10.1159/000477762. Epub 2017 Jul 20.
• [386] Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
• [387] Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients. Neuropsychopharmacology. 2009 Jun;34(7):1819-28. doi: 10.1038/npp.2009.4. Epub 2009 Mar 18.
• [388] Re-expression of CXCL14, a common target for epigenetic silencing in lung cancer, induces tumor necrosis. Oncogene. 2010 Sep 16;29(37):5159-70. doi: 10.1038/onc.2010.255. Epub 2010 Jun 21.
• [389] Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor. Eur J Biochem. 2002 Mar;269(6):1714-25. doi: 10.1046/j.1432-1327.2002.02817.x.
• [390] Genetic and ethnic risk factors associated with drug hypersensitivity. Curr Opin Allergy Clin Immunol. 2010 Aug;10(4):280-90. doi: 10.1097/ACI.0b013e32833b1eb3.
• [391] Hydrogen peroxide induces adaptive response and differential gene expression in human embryo lung fibroblast cells. Environ Toxicol. 2014 Apr;29(4):478-85. doi: 10.1002/tox.21775. Epub 2012 Apr 7.
• [392] Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin. J Neurochem. 2004 Mar;88(5):1211-9. doi: 10.1046/j.1471-4159.2003.02247.x.
• [393] Prolyl endopeptidase is involved in cellular signalling in human neuroblastoma SH-SY5Y cells. Neurosignals. 2011;19(2):97-109. doi: 10.1159/000326342. Epub 2011 Apr 10.
• [394] ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis. Blood. 2004 Jan 1;103(1):194-207.
• [395] Transcriptomic analysis of human primary bronchial epithelial cells after chloropicrin treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.
• [396] Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
• [397] Chemokine stromal cell-derived factor-1 induction by C/EBPbeta activation is associated with all-trans-retinoic acid-induced leukemic cell differentiation. J Leukoc Biol. 2007 Nov;82(5):1332-9. doi: 10.1189/jlb.1106697. Epub 2007 Jul 26.
• [398] How benzene and its metabolites affect human marrow derived mesenchymal stem cells. Toxicol Lett. 2012 Oct 17;214(2):145-53. doi: 10.1016/j.toxlet.2012.08.015. Epub 2012 Aug 30.
• [399] Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
• [400] The aryl hydrocarbon receptor activates the retinoic acid receptoralpha through SMRT antagonism. Biochimie. 2006 Mar-Apr;88(3-4):387-97. doi: 10.1016/j.biochi.2005.11.007. Epub 2005 Dec 7.
• [401] Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
• [402] Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environ Health Perspect. 2008 Apr;116(4):524-31. doi: 10.1289/ehp.10861.
• [403] Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
• [404] Retinoids and retinol differentially regulate steroid biosynthesis in ovarian theca cells isolated from normal cycling women and women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2005 Aug;90(8):4858-65. doi: 10.1210/jc.2005-0330. Epub 2005 May 24.
• [405] Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
• [406] Steroidogenic gene expression in H295R cells and the human adrenal gland: adrenotoxic effects of lindane in vitro. J Appl Toxicol. 2006 Nov-Dec;26(6):484-92.
• [407] Differential effects of antiepileptic drugs on steroidogenesis in a human in vitro cell model. Acta Neurol Scand Suppl. 2009;(189):14-21.
• [408] Glucocorticoid-activation system mediated glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis programming alteration of adrenal dysfunction induced by prenatal caffeine exposure. Toxicol Lett. 2019 Mar 1;302:7-17.
• [409] Direct rosiglitazone action on steroidogenesis and proinflammatory factor production in human granulosa-lutein cells. Reprod Biol Endocrinol. 2009 Dec 9;7:147. doi: 10.1186/1477-7827-7-147.
• [410] Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
• [411] Research resource: STR DNA profile and gene expression comparisons of human BG-1 cells and a BG-1/MCF-7 clonal variant. Mol Endocrinol. 2014 Dec;28(12):2072-81.
• [412] Gene expression analysis using human cancer xenografts to identify novel predictive marker genes for the efficacy of 5-fluorouracil-based drugs. Cancer Sci. 2006 Jun;97(6):510-22. doi: 10.1111/j.1349-7006.2006.00204.x.
• [413] Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
• [414] Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: role of nuclear factor-kappaB and reactive oxygen species. J Cell Biochem. 2005 Aug 1;95(5):955-69. doi: 10.1002/jcb.20452.
• [415] Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids. Toxicol Mech Methods. 2023 Jun;33(5):401-410. doi: 10.1080/15376516.2022.2156005. Epub 2022 Dec 19.
• [416] Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environ Health Perspect. 2003 May;111(6):825-35.
• [417] Cysteamine suppresses invasion, metastasis and prolongs survival by inhibiting matrix metalloproteinases in a mouse model of human pancreatic cancer. PLoS One. 2012;7(4):e34437. doi: 10.1371/journal.pone.0034437. Epub 2012 Apr 20.
• [418] Regulation of vascular smooth muscle cell expression and function of matrix metalloproteinases is mediated by estrogen and progesterone exposure. J Vasc Surg. 2009 Jan;49(1):185-91. doi: 10.1016/j.jvs.2008.07.080. Epub 2008 Oct 1.
• [419] Marked regression of liver metastasis by combined therapy of ultrasound-mediated NF kappaB-decoy transfer and transportal injection of paclitaxel, in mouse. Int J Cancer. 2008 Apr 1;122(7):1645-56. doi: 10.1002/ijc.23280.
• [420] Up-regulated gene expression of angiogenesis factors in post-chemotherapeutic lung cancer tissues determined by cDNA macroarray. Oncol Rep. 2002 Jul-Aug;9(4):723-8.
• [421] Effect of ovarian steroids on gene expression profile in human uterine microvascular endothelial cells. Fertil Steril. 2009 Aug;92(2):709-21.
• [422] Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
• [423] Effects of antiepileptic drugs on lipogenic gene regulation and hyperlipidemia risk in Taiwan: a nationwide population-based cohort study and supporting in vitro studies. Arch Toxicol. 2018 Sep;92(9):2829-2844. doi: 10.1007/s00204-018-2263-3. Epub 2018 Jul 13.
• [424] Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C/EBP-SIRT1 pathway. Toxicology. 2019 Apr 1;417:23-34. doi: 10.1016/j.tox.2019.02.008. Epub 2019 Feb 15.
• [425] Brexpiprazole suppresses cell proliferation and de novo lipogenesis through AMPK/SREBP1 pathway in colorectal cancer. Environ Toxicol. 2023 Oct;38(10):2352-2360. doi: 10.1002/tox.23871. Epub 2023 Jun 22.
• [426] Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals. Int J Mol Sci. 2021 Oct 12;22(20):11005. doi: 10.3390/ijms222011005.
• [427] Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 2009 Aug 21;138(4):645-659. doi: 10.1016/j.cell.2009.06.034. Epub 2009 Aug 13.
• [428] Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells. Mol Cancer Ther. 2007 Nov;6(11):3071-9. doi: 10.1158/1535-7163.MCT-07-0117.
• [429] Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
• [430] Death receptor 5 regulation during selenium-mediated apoptosis in human prostate cancer cells. Cancer Biol Ther. 2002 May-Jun;1(3):287-90. doi: 10.4161/cbt.83.
• [431] Combination of Poly I:C and arsenic trioxide triggers apoptosis synergistically via activation of TLR3 and mitochondrial pathways in hepatocellular carcinoma cells. Cell Biol Int. 2011 Aug;35(8):803-10. doi: 10.1042/CBI20100739.
• [432] Role of mitochondria in aspirin-induced apoptosis in human gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2005 Oct;289(4):G731-8. doi: 10.1152/ajpgi.00150.2005. Epub 2005 Jun 23.
• [433] p38 MAPK/PP2Ac/TTP pathway on the connection of TNF- and caspases activation on hydroquinone-induced apoptosis. Carcinogenesis. 2013 Apr;34(4):818-27. doi: 10.1093/carcin/bgs409. Epub 2013 Jan 3.
• [434] Capsaicin inhibits the migration, invasion and EMT of renal cancer cells by inducing AMPK/mTOR-mediated autophagy. Chem Biol Interact. 2022 Oct 1;366:110043. doi: 10.1016/j.cbi.2022.110043. Epub 2022 Aug 28.
• [435] Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
• [436] Effect of cyclophosphamide on gene expression of cytochromes p450 and beta-actin in the HL-60 cell line. Eur J Pharmacol. 2002 Aug 9;449(3):197-205.
• [437] Isobaric tags for relative and absolute quantitation-based proteomics analysis of the effect of ginger oil on bisphenol A-induced breast cancer cell proliferation. Oncol Lett. 2021 Feb;21(2):101. doi: 10.3892/ol.2020.12362. Epub 2020 Dec 8.
• [438] Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
• [439] Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011 Feb 18;24(2):165-7. doi: 10.1021/tx1004419. Epub 2011 Feb 4.
• [440] Proteasome inhibition creates a chromatin landscape favorable to RNA Pol II processivity. J Biol Chem. 2020 Jan 31;295(5):1271-1287. doi: 10.1074/jbc.RA119.011174. Epub 2019 Dec 5.
• [441] Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines. Chem Biol Interact. 2010 Oct 6;188(1):214-9.
• [442] Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
• [443] Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
• [444] Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
• [445] Rosiglitazone activation of PPARgamma suppresses fractalkine signaling. J Mol Endocrinol. 2010 Feb;44(2):135-42. doi: 10.1677/JME-09-0090. Epub 2009 Oct 22.
• [446] Effects of aspirin on metastasis-associated gene expression detected by cDNA microarray. Acta Pharmacol Sin. 2004 Oct;25(10):1327-33.
• [447] Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
• [448] Bortezomib restores stroma-mediated APO2L/TRAIL apoptosis resistance in multiple myeloma. Eur J Haematol. 2010 Mar;84(3):212-22. doi: 10.1111/j.1600-0609.2009.01381.x. Epub 2009 Nov 17.
• [449] Morphine treatment of human monocyte-derived macrophages induces differential miRNA and protein expression: impact on inflammation and oxidative stress in the central nervous system. J Cell Biochem. 2010 Jul 1;110(4):834-45. doi: 10.1002/jcb.22592.
• [450] Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan;92(1):469-485.
• [451] Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer. Cancer Res. 2006 Mar 1;66(5):2765-77.
• [452] Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134. doi: 10.1016/j.envres.2019.03.035. Epub 2019 Mar 18.
• [453] The genome-wide expression profile of Scrophularia ningpoensis-treated thapsigargin-stimulated U-87MG cells. Neurotoxicology. 2009 May;30(3):368-76.
• [454] Circulating endothelial progenitor cells in multiple myeloma: implications and significance. Blood. 2005 Apr 15;105(8):3286-94. doi: 10.1182/blood-2004-06-2101. Epub 2004 Dec 23.
• [455] Propranolol inhibits proliferation and induces apoptosis of hemangioma-derived endothelial cells via Akt pathway by down-regulating Ang-2 expression. Chem Biol Interact. 2020 Jan 25;316:108925. doi: 10.1016/j.cbi.2019.108925. Epub 2019 Dec 12.
• [456] Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells. Carcinogenesis. 2011 May;32(5):686-94. doi: 10.1093/carcin/bgr025. Epub 2011 Feb 10.
• [457] Malathion induced cancer-linked gene expression in human lymphocytes. Environ Res. 2020 Mar;182:109131. doi: 10.1016/j.envres.2020.109131. Epub 2020 Jan 10.
• [458] Rigosertib as a selective anti-tumor agent can ameliorate multiple dysregulated signaling transduction pathways in high-grade myelodysplastic syndrome. Sci Rep. 2014 Dec 4;4:7310. doi: 10.1038/srep07310.
• [459] Functional characterization of BTK(C481S) mutation that confers ibrutinib resistance: exploration of alternative kinase inhibitors. Leukemia. 2015 Apr;29(4):895-900. doi: 10.1038/leu.2014.263. Epub 2014 Sep 5.
• [460] Characterization of arsenic trioxide resistant clones derived from Jurkat leukemia T cell line: focus on PI3K/Akt signaling pathway. Chem Biol Interact. 2013 Oct 5;205(3):198-211. doi: 10.1016/j.cbi.2013.07.011. Epub 2013 Aug 2.
• [461] Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells. Br J Pharmacol. 2013 May;169(1):167-78.
• [462] Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.
• [463] Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49. doi: 10.1016/j.placenta.2019.10.008. Epub 2019 Oct 17.
• [464] Nicotinic modulation of gene expression in SH-SY5Y neuroblastoma cells. Brain Res. 2006 Oct 20;1116(1):39-49.
• [465] Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes. Arch Toxicol. 2016 May;90(5):1103-15. doi: 10.1007/s00204-015-1545-2. Epub 2015 Jun 24.
• [466] Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):166-75.
• [467] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
• [468] Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway. Blood. 2005 Feb 1;105(3):1214-21. doi: 10.1182/blood-2004-03-1182. Epub 2004 Sep 28.
• [469] Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation. Blood. 2008 Feb 1;111(3):1366-77. doi: 10.1182/blood-2007-04-084814. Epub 2007 Oct 25.
• [470] Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
• [471] Cannabidiol induces osteoblast differentiation via angiopoietin1 and p38 MAPK. Environ Toxicol. 2020 Dec;35(12):1318-1325. doi: 10.1002/tox.22996. Epub 2020 Jul 13.
• [472] Ethanol impairs intestinal barrier function in humans through mitogen activated protein kinase signaling: a combined in vivo and in vitro approach. PLoS One. 2014 Sep 16;9(9):e107421. doi: 10.1371/journal.pone.0107421. eCollection 2014.
• [473] Hydrocortisone enhances the barrier properties of HBMEC/ci, a brain microvascular endothelial cell line, through mesenchymal-to-endothelial transition-like effects. Fluids Barriers CNS. 2015 Mar 5;12:7. doi: 10.1186/s12987-015-0003-0. eCollection 2015.
• [474] Role of transporter genes in cisplatin resistance. In Vivo. 2008 May-Jun;22(3):279-83.
• [475] Identification of retinoid-modulated proteins in squamous carcinoma cells using high-throughput immunoblotting. Cancer Res. 2004 Apr 1;64(7):2439-48. doi: 10.1158/0008-5472.can-03-2643.
• [476] Epigenetic activation of O-linked -N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia. EBioMedicine. 2020 Apr;54:102678. doi: 10.1016/j.ebiom.2020.102678. Epub 2020 Apr 6.
• [477] Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner. Carcinogenesis. 2009 Aug;30(8):1320-9. doi: 10.1093/carcin/bgp138. Epub 2009 Jun 5.
• [478] Identification of biomarkers modulated by the rexinoid LGD1069 (bexarotene) in human breast cells using oligonucleotide arrays. Cancer Res. 2006 Dec 15;66(24):12009-18.
• [479] Identification of estrogen-responsive genes in neuroblastoma SK-ER3 cells. J Neurosci. 1997 Jun 15;17(12):4591-9. doi: 10.1523/JNEUROSCI.17-12-04591.1997.
• [480] Differential expression of genes induced by resveratrol in LNCaP cells: P53-mediated molecular targets. Int J Cancer. 2003 Mar 20;104(2):204-12.
• [481] [Impact of arsenic trioxide on proliferation and metastasis of drug-resistant human ovarian carcinoma cell line]. Ai Zheng. 2002 Aug;21(8):863-7.
• [482] MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
• [483] Effects of metformin and pioglitazone combination on apoptosis and AMPK/mTOR signaling pathway in human anaplastic thyroid cancer cells. J Biochem Mol Toxicol. 2020 Oct;34(10):e22547. doi: 10.1002/jbt.22547. Epub 2020 Jun 26.
• [484] Histopathologic and immunohistochemical features in human skin after exposure to nitrogen and sulfur mustard. Am J Dermatopathol. 1998 Feb;20(1):22-8. doi: 10.1097/00000372-199802000-00005.
• [485] Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
• [486] Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells. Mol Cancer Ther. 2012 Oct;11(10):2138-48. doi: 10.1158/1535-7163.MCT-12-0562. Epub 2012 Aug 6.
• [487] Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators. Mol Endocrinol. 2010 Jan;24(1):33-46.
• [488] Arecoline induces epithelial mesenchymal transition in HK2 cells by upregulating the ERK-mediated signaling pathway. Environ Toxicol. 2020 Sep;35(9):1007-1014. doi: 10.1002/tox.22937. Epub 2020 May 22.
• [489] Pattern of expression of apoptosis and inflammatory genes in humans exposed to arsenic and/or fluoride. Sci Total Environ. 2010 Jan 15;408(4):760-7. doi: 10.1016/j.scitotenv.2009.11.016. Epub 2009 Dec 4.
• [490] Bisphenol A effects on gene expression in adipocytes from children: association with metabolic disorders. J Mol Endocrinol. 2015 Jun;54(3):289-303.
• [491] Ovarian steroids, mitogen-activated protein kinases, and/or aspartic proteinases cooperate to control endometrial remodeling by regulating gene expression in the stroma and glands. Endocrinology. 2010 Sep;151(9):4515-26. doi: 10.1210/en.2009-1398. Epub 2010 Jul 21.
• [492] [Construction of subtracted cDNA library in human Jurkat T cell line induced by arsenic trioxide in vitro]. Zhonghua Yu Fang Yi Xue Za Zhi. 2003 Nov;37(6):403-7.
• [493] Gene expression changes associated with cytotoxicity identified using cDNA arrays. Funct Integr Genomics. 2000 Sep;1(2):114-26.
• [494] Effect of all-trans retinoic acid on sodium/iodide symporter expression, radioiodine uptake and gene expression profiles in a human anaplastic thyroid carcinoma cell line. Nucl Med Biol. 2006 Oct;33(7):875-82. doi: 10.1016/j.nucmedbio.2006.07.004.
• [495] Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells. Biochemistry. 2007 Aug 7;46(31):8920-32. doi: 10.1021/bi7000328. Epub 2007 Jul 14.
• [496] The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
• [497] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [498] Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
• [499] Differentially expressed genes in the prostate cancer cell line LNCaP after exposure to androgen and anti-androgen. Cancer Genet Cytogenet. 2006 Apr 15;166(2):130-8. doi: 10.1016/j.cancergencyto.2005.09.012.
• [500] Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
• [501] Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
• [502] Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
• [503] Gene expression changes in primary human nasal epithelial cells exposed to formaldehyde in vitro. Toxicol Lett. 2010 Oct 5;198(2):289-95.
• [504] Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2011 Feb;123(3-5):140-50.
• [505] Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
• [506] In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
• [507] Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane. Bone. 2007 Apr;40(4):876-87. doi: 10.1016/j.bone.2006.11.029. Epub 2006 Dec 28.
• [508] Identification of novel biomarkers for doxorubicin-induced toxicity in human cardiomyocytes derived from pluripotent stem cells. Toxicology. 2015 Feb 3;328:102-11. doi: 10.1016/j.tox.2014.12.018. Epub 2014 Dec 18.
• [509] Application of the adverse outcome pathway concept for investigating developmental neurotoxicity potential of Chinese herbal medicines by using human neural progenitor cells in vitro. Cell Biol Toxicol. 2023 Feb;39(1):319-343. doi: 10.1007/s10565-022-09730-4. Epub 2022 Jun 15.
• [510] Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines. Toxicol Appl Pharmacol. 2010 Nov 15;249(1):91-100.
• [511] Arsenic trioxide increases expression of secreted frizzled-related protein 1 gene and inhibits the WNT/-catenin signaling pathway in Jurkat cells. Exp Ther Med. 2017 May;13(5):2050-2055. doi: 10.3892/etm.2017.4184. Epub 2017 Mar 6.
• [512] Folic acid modulates cancer-associated micro RNAs and inflammatory mediators in neoplastic and non-neoplastic colonic cells in a different way. Mol Nutr Food Res. 2017 Dec;61(12). doi: 10.1002/mnfr.201700260. Epub 2017 Nov 9.
• [513] TNF enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy. Toxicol Lett. 2021 May 15;342:73-84. doi: 10.1016/j.toxlet.2021.02.009. Epub 2021 Feb 17.
• [514] Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20;2:55. doi: 10.1186/1755-8794-2-55.
• [515] Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples. Data Brief. 2016 Mar 26;7:1052-1057. doi: 10.1016/j.dib.2016.03.069. eCollection 2016 Jun.
• [516] Cystathionine metabolic enzymes play a role in the inflammation resolution of human keratinocytes in response to sub-cytotoxic formaldehyde exposure. Toxicol Appl Pharmacol. 2016 Nov 1;310:185-194.
• [517] Cellular reactions to long-term volatile organic compound (VOC) exposures. Sci Rep. 2016 Dec 1;6:37842. doi: 10.1038/srep37842.
• [518] Change in mRNA Expression after Atenolol, a Beta-adrenergic Receptor Antagonist and Association with Pharmacological Response. Arch Drug Inf. 2009 Sep;2(3):41-50. doi: 10.1111/j.1753-5174.2009.00020.x.
• [519] The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
• [520] The retinoid anticancer signal: mechanisms of target gene regulation. Br J Cancer. 2005 Aug 8;93(3):310-8. doi: 10.1038/sj.bjc.6602700.
• [521] Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
• [522] Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. Am J Respir Cell Mol Biol. 2008 Sep;39(3):312-23. doi: 10.1165/rcmb.2008-0012OC. Epub 2008 Apr 17.
• [523] Glycidamide and cis-2-butene-1,4-dial (BDA) as potential carcinogens and promoters of liver cancer - An in vitro study. Food Chem Toxicol. 2022 Aug;166:113251. doi: 10.1016/j.fct.2022.113251. Epub 2022 Jun 21.
• [524] Analysis of the transcriptional regulation of cancer-related genes by aberrant DNA methylation of the cis-regulation sites in the promoter region during hepatocyte carcinogenesis caused by arsenic. Oncotarget. 2015 Aug 28;6(25):21493-506. doi: 10.18632/oncotarget.4085.
• [525] [Effect of hydroquinone on the histone deacetylase in human bone marrow mononuclear cells]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2016 Mar 20;34(3):189-93. doi: 10.3760/cma.j.issn.1001-9391.2016.03.007.
• [526] Valproic acid, but not levetiracetam, selectively decreases HDAC7 and HDAC2 expression in human ovarian cancer cells. Toxicol Lett. 2014 Jan 13;224(2):225-32. doi: 10.1016/j.toxlet.2013.10.035. Epub 2013 Nov 5.
• [527] Effects of chronic exposure to arsenic and estrogen on epigenetic regulatory genes expression and epigenetic code in human prostate epithelial cells. PLoS One. 2012;7(8):e43880. doi: 10.1371/journal.pone.0043880. Epub 2012 Aug 27.
• [528] The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation. Diabetes. 2007 Mar;56(3):767-76. doi: 10.2337/db06-1488.
• [529] Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes. Endocrinology. 2009 Apr;150(4):1976-83. doi: 10.1210/en.2008-0938. Epub 2008 Nov 26.
• [530] Screening the ToxCast Phase 1, Phase 2, and e1k Chemical Libraries for Inhibitors of Iodothyronine Deiodinases. Toxicol Sci. 2019 Apr 1;168(2):430-442. doi: 10.1093/toxsci/kfy302.
• [531] From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
• [532] NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
• [533] Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
• [534] Quantitative Assessment of Arsenite-Induced Perturbation of Ubiquitinated Proteome. Chem Res Toxicol. 2022 Sep 19;35(9):1589-1597. doi: 10.1021/acs.chemrestox.2c00197. Epub 2022 Aug 22.
• [535] Stress-regulated translational attenuation adapts mitochondrial protein import through Tim17A degradation. Cell Metab. 2013 Dec 3;18(6):908-19. doi: 10.1016/j.cmet.2013.11.006.
• [536] Alterations in eotaxin, monocyte chemoattractant protein-4, interleukin-5, and interleukin-13 after systemic steroid treatment for nasal polyps. Otolaryngol Head Neck Surg. 2004 Nov;131(5):585-9. doi: 10.1016/j.otohns.2004.05.028.
• [537] Adipogenic Effects and Gene Expression Profiling of Firemaster? 550 Components in Human Primary Preadipocytes. Environ Health Perspect. 2017 Sep 14;125(9):097013. doi: 10.1289/EHP1318.
• [538] Chemicals with weak skin sensitizing properties can be identified using low-density microarrays on immature dendritic cells. Toxicol Lett. 2007 Nov 1;174(1-3):98-109. doi: 10.1016/j.toxlet.2007.08.015. Epub 2007 Sep 5.
• [539] A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302. doi: 10.1371/journal.pone.0178302. eCollection 2017.
• [540] Epigenetic silencing of novel tumor suppressors in malignant melanoma. Cancer Res. 2006 Dec 1;66(23):11187-93. doi: 10.1158/0008-5472.CAN-06-1274.
• [541] Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food Chem Toxicol. 2020 Feb;136:111047. doi: 10.1016/j.fct.2019.111047. Epub 2019 Dec 12.
• [542] In vivo biological effects of ATRA in the treatment of AML. Expert Opin Investig Drugs. 2008 Nov;17(11):1623-33. doi: 10.1517/13543784.17.11.1623.
• [543] Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci. 2014 Jun;139(2):328-37. doi: 10.1093/toxsci/kfu053. Epub 2014 Mar 27.
• [544] A high concentration of genistein down-regulates activin A, Smad3 and other TGF-beta pathway genes in human uterine leiomyoma cells. Exp Mol Med. 2012 Apr 30;44(4):281-92.
• [545] PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. Nature. 2014 Oct 9;514(7521):247-51.
• [546] Benzo[a]pyrene increases the Nrf2 content by downregulating the Keap1 message. Toxicol Sci. 2010 Aug;116(2):549-61.
• [547] Identification of troglitazone responsive genes: induction of RTP801 during troglitazone-induced apoptosis in Hep 3B cells. BMB Rep. 2010 Sep;43(9):599-603. doi: 10.5483/BMBRep.2010.43.9.599.
• [548] Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
• [549] Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
• [550] Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 2013 Mar;3(3):308-23.
• [551] A distinct and replicable variant of the squamous cell carcinoma gene inositol polyphosphate-5-phosphatase modifies the susceptibility of arsenic-associated skin lesions in Bangladesh. Cancer. 2015 Jul 1;121(13):2222-9. doi: 10.1002/cncr.29291. Epub 2015 Mar 10.
• [552] Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells. Lipids Health Dis. 2010 Jun 2;9:56. doi: 10.1186/1476-511X-9-56.
• [553] Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst Biol. 2012 Dec 10;6:152.
• [554] Ouabain at pathological concentrations might induce damage in human vascular endothelial cells. Acta Pharmacol Sin. 2006 Feb;27(2):165-72. doi: 10.1111/j.1745-7254.2006.00244.x.
• [555] Gamma-irradiation and doxorubicin treatment of normal human cells cause cell cycle arrest via different pathways. Mol Cells. 2005 Dec 31;20(3):331-8.
• [556] Gene expression profile analysis of gallic acid-induced cell death process. Sci Rep. 2021 Aug 18;11(1):16743. doi: 10.1038/s41598-021-96174-1.
• [557] Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer. Breast Cancer Res Treat. 2007 Jul;103(3):283-91. doi: 10.1007/s10549-006-9377-7. Epub 2007 Jan 27.
• [558] Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
• [559] Up-regulation of hepatic fatty acid transporters and inhibition/down-regulation of hepatic OCTN2 contribute to olanzapine-induced liver steatosis. Toxicol Lett. 2019 Nov;316:183-193. doi: 10.1016/j.toxlet.2019.08.013. Epub 2019 Aug 19.
• [560] Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice. Toxicol Appl Pharmacol. 2017 Feb 1;316:74-82. doi: 10.1016/j.taap.2016.12.019. Epub 2016 Dec 28.
• [561] Estrogen receptor alpha (ER)-mediated coregulator binding and gene expression discriminates the toxic ER agonist diethylstilbestrol (DES) from the endogenous ER agonist 17-estradiol (E2). Cell Biol Toxicol. 2020 Oct;36(5):417-435. doi: 10.1007/s10565-020-09516-6. Epub 2020 Feb 22.
• [562] A fine-needle aspirate-based vulnerability assay identifies polo-like kinase 1 as a mediator of gemcitabine resistance in pancreatic cancer. Mol Cancer Ther. 2010 Feb;9(2):311-8. doi: 10.1158/1535-7163.MCT-09-0693. Epub 2010 Jan 26.
• [563] Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor alpha signalling and results in tamoxifen insensitive proliferation. BMC Cancer. 2014 Apr 23;14:283.
• [564] Ultradian cortisol pulsatility encodes a distinct, biologically important signal. PLoS One. 2011 Jan 18;6(1):e15766.
• [565] Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int. 2021 Nov;156:106730. doi: 10.1016/j.envint.2021.106730. Epub 2021 Jun 27.
• [566] SGK1, a potential regulator of c-fms related breast cancer aggressiveness. Clin Exp Metastasis. 2004;21(6):477-83.
• [567] Species-specific differences in the inhibition of human and zebrafish 11beta-hydroxysteroid dehydrogenase 2 by thiram and organotins. Toxicology. 2012 Nov 15;301(1-3):72-8.
• [568] Inhibition of 11-hydroxysteroid dehydrogenase 2 by the fungicides itraconazole and posaconazole. Biochem Pharmacol. 2017 Apr 15;130:93-103. doi: 10.1016/j.bcp.2017.01.010. Epub 2017 Jan 25.
• [569] cAMP/PKA/EGR1 signaling mediates the molecular mechanism of ethanol-induced inhibition of placental 11beta-HSD2 expression. Toxicol Appl Pharmacol. 2018 Aug 1;352:77-86.
• [570] The anabolic androgenic steroid fluoxymesterone inhibits 11beta-hydroxysteroid dehydrogenase 2-dependent glucocorticoid inactivation. Toxicol Sci. 2012 Apr;126(2):353-61.
• [571] Protective effects of S-carvedilol on doxorubicin-induced damages to human umbilical vein endothelial cells and rats. J Appl Toxicol. 2019 Aug;39(8):1233-1244. doi: 10.1002/jat.3809. Epub 2019 May 7.
• [572] Oxidative stress in kidney transplant patients with calcineurin inhibitor-induced hypertension: effect of ramipril. J Cardiovasc Pharmacol. 2002 Oct;40(4):625-31.
• [573] Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of Sp1 activity. DNA Cell Biol. 2009 Mar;28(3):119-29.
• [574] Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs. Am J Respir Crit Care Med. 2005 Oct 15;172(8):987-93. doi: 10.1164/rccm.200501-041OC. Epub 2005 Jul 7.
• [575] A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase. Nitric Oxide. 2005 Mar;12(2):97-104.
• [576] The thiazolidinedione drug troglitazone up-regulates nitric oxide synthase expression in vascular endothelial cells. J Diabetes Complications. 2006 Sep-Oct;20(5):336-42.
• [577] Fructose induces the inflammatory molecule ICAM-1 in endothelial cells. J Am Soc Nephrol. 2008 Sep;19(9):1712-20.
• [578] Upregulation of nitric oxide production in vascular endothelial cells by all-trans retinoic acid through the phosphoinositide 3-kinase/Akt pathway. Circulation. 2005 Aug 2;112(5):727-36. doi: 10.1161/CIRCULATIONAHA.104.500959. Epub 2005 Jul 25.
• [579] Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicol Sci. 2010 Dec; 118(2):485-500.
• [580] Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). Toxicol Sci. 2013 Dec;136(2):328-43.
• [581] Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals. Chem Res Toxicol. 2017 May 15;30(5):1219-1229. doi: 10.1021/acs.chemrestox.7b00048. Epub 2017 May 4.
• [582] A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicol Sci. 2013 Nov;136(1):216-41.
• [583] Comparative effects of microtubules disruption on glucocorticoid receptor functions in proliferating and quiescent cells. Int J Toxicol. 2010 May-Jun;29(3):326-35. doi: 10.1177/1091581810366486.
• [584] Adipocyte differentiation, mitochondrial gene expression and fat distribution: differences between zidovudine and tenofovir after 6 months. Antivir Ther. 2009;14(8):1089-100. doi: 10.3851/IMP1457.
• [585] Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma. Head Neck. 2011 Jul;33(7):959-68. doi: 10.1002/hed.21559. Epub 2010 Aug 24.
• [586] Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis. Biochem Pharmacol. 2009 Apr 15;77(8):1410-7.
• [587] Drug sensitivity and drug resistance profiles of human intrahepatic cholangiocarcinoma cell lines. World J Gastroenterol. 2005 May 14;11(18):2748-53. doi: 10.3748/wjg.v11.i18.2748.
• [588] Adaptive homeostasis of the vitamin D-vitamin D nuclear receptor axis in 8-methoxypsoralen-induced hepatotoxicity. Toxicol Appl Pharmacol. 2019 Jan 1;362:150-158. doi: 10.1016/j.taap.2018.11.002. Epub 2018 Nov 10.
• [589] Differential regulation of the human MRP2 and MRP3 gene expression by glucocorticoids. J Steroid Biochem Mol Biol. 2005 Aug;96(3-4):229-34. doi: 10.1016/j.jsbmb.2005.03.004.
• [590] Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells. Biochem Biophys Res Commun. 2002 Feb 8;290(5):1427-33. doi: 10.1006/bbrc.2002.6367.
• [591] Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells. Mol Pharmacol. 2008 Aug;74(2):476-84.
• [592] Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. Toxicol Lett. 2015 Jan 5;232(1):193-202. doi: 10.1016/j.toxlet.2014.10.009. Epub 2014 Oct 16.
• [593] Induction of PXR-mediated metabolism by beta-carotene. Biochim Biophys Acta. 2005 May 30;1740(2):162-9. doi: 10.1016/j.bbadis.2004.11.013. Epub 2004 Dec 8.
• [594] Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). Toxicol Appl Pharmacol. 2005 Dec 1;209(2):123-33. doi: 10.1016/j.taap.2005.03.015.
• [595] Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening. Drug Metab Dispos. 2011 Feb;39(2):337-44. doi: 10.1124/dmd.110.035808. Epub 2010 Nov 10.
• [596] Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor. Toxicol Lett. 2017 Jan 4;265:86-96.
• [597] Chemotaxis of human CD4+ eosinophils. Int Arch Allergy Immunol. 2001;125 Suppl 1:19-21. doi: 10.1159/000053847.
• [598] Rimexolone inhibits proliferation, cytokine expression and signal transduction of human CD4+ T-cells. Immunol Lett. 2010 Jun 15;131(1):24-32. doi: 10.1016/j.imlet.2010.03.009. Epub 2010 Apr 2.
• [599] Mechanisms of dexamethasone-induced disturbed sleep and fatigue in paediatric patients receiving treatment for ALL. Eur J Cancer. 2010 Jul;46(10):1848-55. doi: 10.1016/j.ejca.2010.03.026. Epub 2010 Apr 17.
• [600] Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
• [601] ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
• [602] (9)-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7-Stimulated Human Coculture. J Pharmacol Exp Ther. 2019 Oct;371(1):191-201. doi: 10.1124/jpet.119.260661. Epub 2019 Aug 5.
• [603] Blood cell oxidative stress precedes hemolysis in whole blood-liver slice co-cultures of rat, dog, and human tissues. Toxicol Appl Pharmacol. 2010 May 1;244(3):354-65. doi: 10.1016/j.taap.2010.01.017. Epub 2010 Feb 6.
• [604] Indomethacin inhibits cell growth of medullary thyroid carcinoma by reducing cell cycle progression into S phase. Exp Biol Med (Maywood). 2008 Nov;233(11):1433-40. doi: 10.3181/0804-RM-127. Epub 2008 Sep 12.
• [605] Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer. Endocr Relat Cancer. 2011 Apr 28;18(3):333-45. doi: 10.1530/ERC-10-0262. Print 2011 Jun.
• [606] Effects and mechanisms of betulinic acid on improving EGFR TKI-resistance of lung cancer cells. Environ Toxicol. 2018 Nov;33(11):1153-1159.
• [607] BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
• [608] Sulindac induces specific degradation of the HPV oncoprotein E7 and causes growth arrest and apoptosis in cervical carcinoma cells. Cancer Lett. 2007 Jan 8;245(1-2):103-11. doi: 10.1016/j.canlet.2005.12.034. Epub 2006 Feb 20.
• [609] Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance. Exp Cell Res. 2012 Jun 10;318(10):1146-59.
• [610] HMG-CoA reductase inhibitor simvastatin inhibits cell cycle progression at the G1/S checkpoint in immortalized lymphocytes from Alzheimer's disease patients independently of cholesterol-lowering effects. J Pharmacol Exp Ther. 2008 Jan;324(1):352-9. doi: 10.1124/jpet.107.128959. Epub 2007 Oct 10.
• [611] Effects of the environmental estrogens bisphenol A, o,p'-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7. J Steroid Biochem Mol Biol. 2002 Jan;80(1):61-70. doi: 10.1016/s0960-0760(01)00173-x.
• [612] Conception and pharmacodynamic profile of drospirenone. Steroids. 2003 Nov;68(10-13):891-905. doi: 10.1016/j.steroids.2003.08.008.
• [613] Biological activity of all-trans-retinoic acid with and without tamoxifen and alpha-interferon 2a in breast cancer patients. Int J Oncol. 2000 Nov;17(5):991-1000. doi: 10.3892/ijo.17.5.991.
• [614] Estrogen-induced loss of progesterone receptor expression in normal and malignant ovarian surface epithelial cells. Oncogene. 2005 Jun 23;24(27):4388-400. doi: 10.1038/sj.onc.1208623.
• [615] Tibolone and its metabolites enhance tissue factor and PAI-1 expression in human endometrial stromal cells: Evidence of progestogenic effects. Steroids. 2005 Nov;70(12):840-5. doi: 10.1016/j.steroids.2005.04.010.
• [616] Expression of estrogen-, progesterone-, and androgen-responsive genes in MCF-7 and MDA-MB-231 cells treated with o,p'-DDT, p,p'-DDT, or endosulfan. J Biochem Mol Toxicol. 2021 Jun;35(6):1-8. doi: 10.1002/jbt.22773. Epub 2021 Mar 16.
• [617] Characterization of the weak estrogen receptor alpha agonistic activity of exemestane. Breast Cancer Res Treat. 2009 Aug;116(3):461-70. doi: 10.1007/s10549-008-0151-x. Epub 2008 Aug 3.
• [618] A comparative study of the effect of raloxifene and gosereline on uterine leiomyoma volume changes and estrogen receptor, progesterone receptor, bcl-2 and p53 expression immunohistochemically in premenopausal women. Eur J Obstet Gynecol Reprod Biol. 2007 Nov;135(1):94-103. doi: 10.1016/j.ejogrb.2006.07.042. Epub 2006 Sep 14.
• [619] Serum free BG-1 cell proliferation assay: a sensitive method for determining organochlorine pesticide estrogen receptor activation at the nanomolar range. Toxicol In Vitro. 2006 Apr;20(3):382-94. doi: 10.1016/j.tiv.2005.08.016. Epub 2005 Oct 19.
• [620] Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013 Apr 25;203(2):412-22. doi: 10.1016/j.cbi.2013.03.011. Epub 2013 Mar 22.
• [621] Cigarette smoke and asbestos activate poly-ADP-ribose polymerase in alveolar epithelial cells. J Investig Med. 2001 Jan;49(1):68-76. doi: 10.2310/6650.2001.34092.
• [622] The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. doi: 10.1002/(sici)1099-0461(1999)13:6<338::aid-jbt8>3.0.co;2-7.
• [623] Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
• [624] Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
• [625] Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
• [626] Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells. Clin Exp Immunol. 2007 May;148(2):288-95. doi: 10.1111/j.1365-2249.2007.03335.x. Epub 2007 Feb 7.
• [627] TBECH, 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane, alters androgen receptor regulation in response to mutations associated with prostate cancer. Toxicol Appl Pharmacol. 2016 Sep 15;307:91-101. doi: 10.1016/j.taap.2016.07.018. Epub 2016 Jul 27.
• [628] Targeting chromatin binding regulation of constitutively active AR variants to overcome prostate cancer resistance to endocrine-based therapies. Nucleic Acids Res. 2015 Jul 13;43(12):5880-97. doi: 10.1093/nar/gkv262. Epub 2015 Apr 23.
• [629] Possible role of adaptive mutation in resistance to antiandrogen in prostate cancer cells. Prostate. 2005 Nov 1;65(3):268-75. doi: 10.1002/pros.20282.
• [630] Identifying environmental chemicals as agonists of the androgen receptor by using a quantitative high-throughput screening platform. Toxicology. 2017 Jun 15;385:48-58. doi: 10.1016/j.tox.2017.05.001. Epub 2017 May 4.
• [631] Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Sci Rep. 2014 Sep 26;4:6437. doi: 10.1038/srep06437.
• [632] Prostate specific antigen expression is down-regulated by selenium through disruption of androgen receptor signaling. Cancer Res. 2004 Jan 1;64(1):19-22. doi: 10.1158/0008-5472.can-03-2789.
• [633] Comparison of the Hershberger assay and androgen receptor binding assay of twelve chemicals. Toxicology. 2004 Feb 15;195(2-3):177-86. doi: 10.1016/j.tox.2003.09.012.
• [634] 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
• [635] Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
• [636] Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
• [637] Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
• [638] Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
• [639] Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
• [640] Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
• [641] -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
• [642] Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
• [643] Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation. Toxicol Appl Pharmacol. 2021 Mar 15;415:115450. doi: 10.1016/j.taap.2021.115450. Epub 2021 Feb 9.
• [644] Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
• [645] CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models. Genes Cancer. 2014 Jul;5(7-8):261-72. doi: 10.18632/genesandcancer.24.
• [646] The differential effects of neuroleptic drugs and PACAP on the expression of BDNF mRNA and protein in a human glioblastoma cell line. Acta Neurobiol Exp (Wars). 2017;77(3):205-213.
• [647] Tea polyphenols ameliorates neural redox imbalance and mitochondrial dysfunction via mechanisms linking the key circadian regular Bmal1. Food Chem Toxicol. 2017 Dec;110:189-199. doi: 10.1016/j.fct.2017.10.031. Epub 2017 Oct 20.
• [648] LncRNA SNHG12 ameliorates bupivacaine-induced neurotoxicity by sponging miR-497-5p to upregulate NLRX1. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089001. doi: 10.1177/09603271221089001.
• [649] Mechanism of arsenic trioxide inhibiting angiogenesis in multiple myeloma. J Huazhong Univ Sci Technolog Med Sci. 2006;26(1):43-6. doi: 10.1007/BF02828035.
• [650] Oxidative stress modulates expression of immune checkpoint genes via activation of AhR signaling. Toxicol Appl Pharmacol. 2022 Dec 15;457:116314. doi: 10.1016/j.taap.2022.116314. Epub 2022 Nov 9.
• [651] Profiling of enantiopure drugs towards aryl hydrocarbon (AhR), glucocorticoid (GR) and pregnane X (PXR) receptors in human reporter cell lines. Chem Biol Interact. 2014 Feb 5;208:64-76. doi: 10.1016/j.cbi.2013.11.018. Epub 2013 Dec 6.
• [652] Involvement of cytoskeleton in AhR-dependent CYP1A1 expression. Curr Drug Metab. 2006 Apr;7(3):301-13. doi: 10.2174/138920006776359310.
• [653] Sulindac and its metabolites induce carcinogen metabolizing enzymes in human colon cancer cells. Int J Cancer. 2008 Mar 1;122(5):990-8.
• [654] Quercetin, quercetin glycosides and taxifolin differ in their ability to induce AhR activation and CYP1A1 expression in HepG2 cells. Phytother Res. 2012 Nov;26(11):1746-52.
• [655] Omeprazole inhibits pancreatic cancer cell invasion through a nongenomic aryl hydrocarbon receptor pathway. Chem Res Toxicol. 2015 May 18;28(5):907-18.
• [656] Induction of paraoxonase 1 and apolipoprotein A-I gene expression by aspirin. J Lipid Res. 2008 Oct;49(10):2142-8.
• [657] Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
• [658] [Mechanisms underlying the effect of arsenic trioxide on proliferation inhibition and apoptosis induction in myeloma cell line u266]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Oct;15(5):982-5.
• [659] Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
• [660] Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
• [661] Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
• [662] Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
• [663] Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
• [664] Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
• [665] mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
• [666] Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
• [667] Effect of menstrual cycle and hormonal treatment on ki-67 and bcl-2 expression and adenomyosis. Gynecol Endocrinol. 2005 Mar;20(3):127-31. doi: 10.1080/09513590400021086.
• [668] An in vitro study on anti-carcinogenic effect of remdesivir in human ovarian cancer cells via generation of reactive oxygen species. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089257. doi: 10.1177/09603271221089257.
• [669] Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
• [670] Mitophagy inhibits proliferation by decreasing cyclooxygenase-2 (COX-2) in arsenic trioxide-treated HepG2 cells. Environ Toxicol Pharmacol. 2016 Jul;45:212-21.
• [671] Thalidomide suppresses angiogenesis and immune evasion via lncRNA FGD5-AS1/miR-454-3p/ZEB1 axis-mediated VEGFA expression and PD-1/PD-L1 checkpoint in NSCLC. Chem Biol Interact. 2021 Nov 1;349:109652. doi: 10.1016/j.cbi.2021.109652. Epub 2021 Sep 11.
• [672] Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
• [673] Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
• [674] Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Arthritis Rheum. 2012 Jun;64(6):1780-9. doi: 10.1002/art.34342. Epub 2011 Dec 19.
• [675] Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. Melanoma Res. 2008 Apr;18(2):85-94. doi: 10.1097/CMR.0b013e3282f60097.
• [676] The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res. 2005 Jan 1;65(1):18-25.
• [677] Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. Biochem Pharmacol. 2001 May 15;61(10):1205-15. doi: 10.1016/s0006-2952(01)00583-4.
• [678] Fluoxetine mediates G0/G1 arrest by inducing functional inhibition of cyclin dependent kinase subunit (CKS)1. Biochem Pharmacol. 2008 May 15;75(10):1924-34. doi: 10.1016/j.bcp.2008.02.013. Epub 2008 Feb 17.
• [679] Induction mechanism of apoptosis by troglitazone through peroxisome proliferator-activated receptor-gamma in gastric carcinoma cells. Anticancer Res. 2003 Jan-Feb;23(1A):267-73.
• [680] Down-regulation of CD44 contributes to the differentiation of HL-60 cells induced by ATRA or HMBA. Cell Mol Immunol. 2007 Feb;4(1):59-63.
• [681] The anti-cancer drug gefitinib accelerates Fas-mediated apoptosis by enhancing caspase-8 activation in cancer cells. J Toxicol Sci. 2019;44(6):435-440. doi: 10.2131/jts.44.435.
• [682] NF-B potentiates caspase independent hydrogen peroxide induced cell death. PLoS One. 2011 Feb 15;6(2):e16815. doi: 10.1371/journal.pone.0016815.
• [683] Carvedilol prevents epinephrine-induced apoptosis in human coronary artery endothelial cells: modulation of Fas/Fas ligand and caspase-3 pathway. Cardiovasc Res. 2000 Feb;45(3):788-94. doi: 10.1016/s0008-6363(99)00369-7.
• [684] Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells. Oncol Rep. 2011 Feb;25(2):583-91. doi: 10.3892/or.2010.1097. Epub 2010 Dec 10.
• [685] Influence of antitumor drugs on the expression of Fas system in SW480 colon cancer cells. Eur J Gastroenterol Hepatol. 2006 Oct;18(10):1071-7. doi: 10.1097/01.meg.0000231750.68513.6c.
• [686] Acrolein enhances epigenetic modifications, FasL expression and hepatocyte toxicity induced by anti-HIV drug Zidovudine. Toxicol In Vitro. 2016 Sep;35:66-76. doi: 10.1016/j.tiv.2016.05.013. Epub 2016 May 26.
• [687] Rifampicin inhibits CD95-mediated apoptosis of Jurkat T cells via glucocorticoid receptors by modifying the expression of molecules regulating apoptosis. J Clin Immunol. 2002 Jan;22(1):37-47. doi: 10.1023/a:1014256603539.
• [688] Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. FASEB J. 2005 Jul;19(9):1067-77. doi: 10.1096/fj.04-3284com.
• [689] Dual anti-inflammatory and anti-parasitic action of topical ivermectin 1% in papulopustular rosacea. J Eur Acad Dermatol Venereol. 2017 Nov;31(11):1907-1911. doi: 10.1111/jdv.14437. Epub 2017 Aug 29.
• [690] Expression and modulation of progesterone induced blocking factor (PIBF) and innate immune factors in human leukemia cell lines by progesterone and mifepristone. Leuk Lymphoma. 2007 Aug;48(8):1610-7. doi: 10.1080/10428190701471999.
• [691] Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids. Mol Nutr Food Res. 2014 Mar;58(3):528-536. doi: 10.1002/mnfr.201300266. Epub 2013 Sep 14.
• [692] MiR-17-5p/FOXL2/CDKN1B signal programming in oocytes mediates transgenerational inheritance of diminished ovarian reserve in female offspring rats induced by prenatal dexamethasone exposure. Cell Biol Toxicol. 2023 Jun;39(3):867-883. doi: 10.1007/s10565-021-09645-6. Epub 2021 Sep 19.
• [693] New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids. Arch Toxicol. 2021 Aug;95(8):2691-2718. doi: 10.1007/s00204-021-03092-2. Epub 2021 Jun 20.
• [694] Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
• [695] In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
• [696] Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
• [697] Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor. Nat Med. 2004 Jan;10(1):40-7. doi: 10.1038/nm969. Epub 2003 Dec 14.
• [698] Estrogen receptor regulates E2F1 expression to mediate tamoxifen resistance. Mol Cancer Res. 2010 Mar;8(3):343-52. doi: 10.1158/1541-7786.MCR-09-0395. Epub 2010 Mar 9.
• [699] Antiproliferative effects of gefitinib are associated with suppression of E2F-1 expression and telomerase activity. Anticancer Res. 2006 Sep-Oct;26(5A):3387-91.
• [700] Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
• [701] Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.
• [702] A Gene Expression Biomarker Identifies Chemical Modulators of Estrogen Receptor in an MCF-7 Microarray Compendium. Chem Res Toxicol. 2021 Feb 15;34(2):313-329. doi: 10.1021/acs.chemrestox.0c00243. Epub 2021 Jan 6.
• [703] Arsenic induces functional re-expression of estrogen receptor by demethylation of DNA in estrogen receptor-negative human breast cancer. PLoS One. 2012;7(4):e35957. doi: 10.1371/journal.pone.0035957. Epub 2012 Apr 27.
• [704] Evaluation of an imaging-based in vitro screening platform for estrogenic activity with OECD reference chemicals. Toxicol In Vitro. 2022 Jun;81:105348. doi: 10.1016/j.tiv.2022.105348. Epub 2022 Mar 18.
• [705] Modulation of cytokine production by dydrogesterone in lymphocytes from women with recurrent miscarriage. BJOG. 2005 Aug;112(8):1096-101. doi: 10.1111/j.1471-0528.2005.00633.x.
• [706] Acanthoic acid protectsagainst ethanol-induced liver injury: Possible role of AMPK activation and IRAK4 inhibition. Toxicol Lett. 2017 Nov 5;281:127-138. doi: 10.1016/j.toxlet.2017.09.020. Epub 2017 Sep 28.
• [707] HCV RNA Activates APCs via TLR7/TLR8 While Virus Selectively Stimulates Macrophages Without Inducing Antiviral Responses. Sci Rep. 2016 Jul 7;6:29447. doi: 10.1038/srep29447.
• [708] Transcriptomics and methylomics of CD4-positive T cells in arsenic-exposed women. Arch Toxicol. 2017 May;91(5):2067-2078. doi: 10.1007/s00204-016-1879-4. Epub 2016 Nov 12.
• [709] High-resolution analysis of 3p deletion in neuroblastoma and differential methylation of the SEMA3B tumor suppressor gene. Cancer Genet Cytogenet. 2007 Apr 15;174(2):100-10. doi: 10.1016/j.cancergencyto.2006.11.017.
• [710] Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation. Mol Endocrinol. 2002 Jun;16(6):1243-56.
• [711] Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse. PLoS One. 2006 Dec 27;1(1):e114. doi: 10.1371/journal.pone.0000114.