Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOMN31)

• Drug Name: PEITC Drug Info
• Synonyms: Phenethyl-isothiocyanate

Indication

Disease Entry	ICD 11	Status	REF
Prostate cancer	2C82.0	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 16741
  ChEBI ID: CHEBI:351346
  CAS Number: CAS 2257-09-2
  TTD Drug ID: DMOMN31
  VARIDT Drug ID: DR01460
  INTEDE Drug ID: DR1867

Molecule-Related Drug Atlas

Drug(s) Transported By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[8]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[12]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[3]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[13]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[14]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[15]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[16]

Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[19]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[20]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[21]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[23]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[24]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[25]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[26]

Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[29]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[31]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[32]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[32]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[34]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[35]

Drug(s) Metabolized By Glutathione S-transferase alpha-1 (GSTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[39]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[40]
Trabectedin	DMG3Y89	Leiomyosarcoma	2B58	Approved	[41]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[42]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[43]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[44]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[45]

Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[46]
Ademetionine	DMYQDBO	Hepatic fibrosis	DB93.0	Approved	[47]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[48]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[49]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[50]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[51]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[48]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[54]

Drug(s) Affected By Cytochrome P450 2A6 (CYP2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tegafur	DM31ZQM	Solid tumour/cancer	2A00-2F9Z	Approved	[55]
Methoxsalen	DME8FZ9	Cutaneous T-cell lymphoma	2B01	Approved	[56]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[51]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[59]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[62]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[63]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[64]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[65]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[70]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[71]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[72]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[73]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[75]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[78]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[79]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[80]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[83]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[84]
Ketoprofen	DMRKXPT	Bursitis		Approved	[48]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[94]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[95]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[97]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[101]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[102]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[103]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[104]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[105]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[106]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[109]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[110]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[111]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[112]

Drug(s) Affected By Protein NDRG1 (NDRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[114]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[115]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[121]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[123]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[123]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[123]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[124]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[125]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[126]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[127]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[128]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[129]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[48]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[130]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[132]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[133]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[134]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[135]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[136]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[137]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[138]

Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[130]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[136]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[136]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[139]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[140]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[142]

Drug(s) Affected By DNA excision repair protein ERCC-5 (ERCC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[146]
Ximelegatran	DMU8ANS	Myocardial infarction	BA41-BA43	Approved	[147]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[148]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[149]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[151]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[87]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[152]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[153]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[155]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]

Drug(s) Affected By DNA repair endonuclease XPF (ERCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[158]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[161]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[163]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
Bortezomib	DMNO38U	Leukemia		Approved	[165]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[166]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[170]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[171]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[111]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[171]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[172]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[173]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[177]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[179]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[183]

Drug(s) Affected By Proteinase-activated receptor 3 (F2RL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[144]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[188]

Drug(s) Affected By Matrilin-2 (MATN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[190]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[193]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[194]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[195]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[163]

Drug(s) Affected By Serine/threonine-protein kinase PLK4 (PLK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[198]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[199]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[200]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[87]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[201]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[201]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[83]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[201]
Fructose	DM43AN2	Vomiting	MD90	Approved	[203]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[196]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[201]

Drug(s) Affected By Aurora kinase A (AURKA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[204]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[97]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[97]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]

Drug(s) Affected By Histone-lysine N-methyltransferase SUV39H1 (SUV39H1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[209]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[211]
Bortezomib	DMNO38U	Leukemia		Approved	[212]

Drug(s) Affected By 5'-AMP-activated protein kinase subunit beta-2 (PRKAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[74]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[215]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]

Drug(s) Affected By Uncharacterized protein KIAA0513 (KIAA0513)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[216]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[217]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[218]

Drug(s) Affected By Myelin protein zero-like protein 2 (MPZL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[220]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[221]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[51]

Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[223]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[224]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]

Drug(s) Affected By Cell division control protein 45 homolog (CDC45)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[225]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[226]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[227]

Drug(s) Affected By F-box and WD repeat domain containing protein 10B (FBXW10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[228]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[229]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[230]

Drug(s) Affected By Kinesin-like protein KIF20A (KIF20A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[204]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[112]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]

Drug(s) Affected By Acyl-CoA 6-desaturase (FADS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[231]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[233]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[236]
Bortezomib	DMNO38U	Leukemia		Approved	[237]

Drug(s) Affected By Ferritin light chain (FTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[238]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[240]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[241]

Drug(s) Affected By Histone H2A type 1-B/E (H2AC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[234]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[227]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[243]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[244]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[246]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[247]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[248]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[250]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[89]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[251]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[252]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[253]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[254]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[255]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[256]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[257]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[258]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[151]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[253]

Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[259]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[260]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[261]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[262]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[263]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[196]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[264]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[265]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[266]

Drug(s) Affected By Gelsolin (GSN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[261]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[267]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[196]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]

Drug(s) Affected By Vitamin K-dependent protein S (PROS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[268]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[234]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[269]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[270]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]

Drug(s) Affected By DNA polymerase alpha catalytic subunit (POLA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[272]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[227]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[198]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[273]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[274]

Drug(s) Affected By Histone H2A type 1 (H2AC11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[234]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[275]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[276]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[227]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[277]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]

Drug(s) Affected By Myb-related protein B (MYBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[278]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[279]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[280]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[272]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[281]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[280]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[283]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]

Drug(s) Affected By Clusterin (CLU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[284]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[284]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[285]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[286]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[158]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[284]

Drug(s) Affected By Pregnancy-specific beta-1-glycoprotein 1 (PSG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[287]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[163]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[288]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[289]

Drug(s) Affected By Tissue factor (F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[290]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[291]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[292]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[293]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[294]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[295]
Fructose	DM43AN2	Vomiting	MD90	Approved	[296]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[297]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[291]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[298]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[299]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[105]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Selenium	DM25CGV	N. A.	N. A.	Approved	[300]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[109]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[111]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[301]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[97]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]

Drug(s) Affected By Transcription factor JunB (JUNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[302]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[303]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[281]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[304]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[305]

Drug(s) Affected By Sphingomyelin phosphodiesterase (SMPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[306]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[307]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[196]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[308]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[309]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[310]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[71]

Drug(s) Affected By DNA ligase 1 (LIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[311]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[199]

Drug(s) Affected By Follistatin (FST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[257]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[312]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[158]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[313]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[314]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[299]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[315]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[316]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[317]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[207]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[318]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]

Drug(s) Affected By Lamin-B1 (LMNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[319]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[320]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[321]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[196]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[322]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]

Drug(s) Affected By Diamine acetyltransferase 1 (SAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[323]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[196]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[324]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[324]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[325]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[326]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[327]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[328]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[329]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[330]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[331]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[332]

Drug(s) Affected By COUP transcription factor 2 (NR2F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[196]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[281]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[333]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[273]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[334]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[316]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[111]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[317]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[335]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[279]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[336]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[337]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[299]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[334]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Selenium	DM25CGV	N. A.	N. A.	Approved	[300]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[111]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[339]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[340]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[341]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[342]

Drug(s) Affected By CD82 antigen (CD82)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[343]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[281]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Bortezomib	DMNO38U	Leukemia		Approved	[237]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[344]

Drug(s) Affected By DNA polymerase delta catalytic subunit (POLD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[278]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[345]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[195]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]

Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[278]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[261]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[346]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[347]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]

Drug(s) Affected By Oxytocin receptor (OXTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[348]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[349]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[350]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[351]

Drug(s) Affected By DNA replication licensing factor MCM5 (MCM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[352]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[272]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]

Drug(s) Affected By DNA replication licensing factor MCM7 (MCM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[318]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[353]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[94]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[354]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[355]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[356]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[357]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]

Drug(s) Affected By Flap endonuclease 1 (FEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[225]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[358]

Drug(s) Affected By Cyclin-F (CCNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[342]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[196]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[272]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[359]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[275]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]

Drug(s) Affected By Cathepsin O (CTSO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[303]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[51]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[119]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[360]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[361]
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[362]

Drug(s) Affected By Chromobox protein homolog 5 (CBX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[363]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[364]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[281]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[215]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[227]

Drug(s) Affected By Centromere protein F (CENPF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[365]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]

Drug(s) Affected By DNA primase small subunit (PRIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[207]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[227]

Drug(s) Affected By DNA replication licensing factor MCM2 (MCM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[366]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]

Drug(s) Affected By Selenide, water dikinase 1 (SEPHS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[221]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[367]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[368]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[360]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[369]

Drug(s) Affected By Breast cancer type 2 susceptibility protein (BRCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[314]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[370]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[281]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[227]

Drug(s) Affected By Rho GDP-dissociation inhibitor 2 (ARHGDIB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[371]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[99]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[234]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[121]

Drug(s) Affected By Serine/threonine-protein kinase PLK1 (PLK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[372]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]

Drug(s) Affected By RecQ-like DNA helicase BLM (BLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]

Drug(s) Affected By DNA polymerase epsilon subunit 2 (POLE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[225]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]

Drug(s) Affected By Period circadian protein homolog 3 (PER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[373]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[288]

Drug(s) Affected By Anaphase-promoting complex subunit 15 (ANAPC15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[178]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[374]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[289]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[375]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[376]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[377]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[378]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[379]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[380]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[281]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[381]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]

Drug(s) Affected By Histone H4 (H4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[97]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[382]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[286]

Drug(s) Affected By Histone H2B type 1-C/E/F/G/I (H2BC10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[234]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[227]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[383]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[243]

Drug(s) Affected By Histone H3.1 (H3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[275]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]

Drug(s) Affected By Vigilin (HDLBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[384]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[385]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[144]

Drug(s) Affected By Kinesin-like protein KIF23 (KIF23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[352]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[386]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]

Drug(s) Affected By D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[234]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[286]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[387]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[388]

Drug(s) Affected By Caveolin-1 (CAV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[327]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[303]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[389]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[390]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[391]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[392]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[393]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[394]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]

Drug(s) Affected By DNA repair protein RAD51 homolog 1 (RAD51)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[223]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[395]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[396]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[397]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[398]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]

Drug(s) Affected By DNA polymerase epsilon catalytic subunit A (POLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[227]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[399]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[218]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]

Drug(s) Affected By Forkhead box protein M1 (FOXM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[223]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[400]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[401]

Drug(s) Affected By Schlafen family member 5 (SLFN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[283]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[277]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[402]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[373]

Drug(s) Affected By Cell division cycle protein 20 homolog (CDC20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[223]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[278]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[403]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[404]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]

Drug(s) Affected By Chromatin assembly factor 1 subunit B (CHAF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[112]

Drug(s) Affected By S-phase kinase-associated protein 2 (SKP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[405]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]

Drug(s) Affected By DNA polymerase alpha subunit B (POLA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[400]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[227]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[358]

Drug(s) Affected By Separin (ESPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[223]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[270]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[273]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]

Drug(s) Affected By Condensin complex subunit 2 (NCAPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[204]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[226]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Haloperidol	DM96SE0	Delirium		Approved	[407]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[283]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[227]

Drug(s) Affected By PCNA-associated factor (PCLAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[204]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[408]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[400]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[358]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]

Drug(s) Affected By 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[234]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[400]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]

Drug(s) Affected By Pachytene checkpoint protein 2 homolog (TRIP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[409]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[283]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 3 (CDKN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[409]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]

Drug(s) Affected By Lymphocyte antigen 6K (LY6K)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[410]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[411]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[209]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[412]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[413]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[414]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[415]
crotylaldehyde	DMTWRQI	Discovery agent	N.A.	Investigative	[416]

Drug(s) Affected By DNA excision repair protein ERCC-6-like (ERCC6L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[283]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[218]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[350]

Drug(s) Affected By Renal cancer differentiation gene 1 protein (C4ORF46)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[273]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[163]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[350]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[143]

Drug(s) Affected By Sigma intracellular receptor 2 (TMEM97)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[403]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[234]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[417]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[158]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]

Drug(s) Affected By Transcriptional protein SWT1 (SWT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[221]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[221]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[195]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[228]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[418]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[419]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[420]

Drug(s) Affected By PHD finger protein 19 (PHF19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[403]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[358]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[421]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[360]

Drug(s) Affected By Pleckstrin homology domain-containing family A member 7 (PLEKHA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[209]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[403]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[422]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[51]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[288]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]

Drug(s) Affected By Rho GTPase-activating protein 11A (ARHGAP11A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[198]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[273]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[51]

Drug(s) Affected By Protein MCM10 homolog (MCM10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[283]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[423]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[358]

Drug(s) Affected By Radial spoke head protein 3 homolog (RSPH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[218]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[419]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[410]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[230]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[412]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[424]

Drug(s) Affected By Ras GTPase-activating-like protein IQGAP3 (IQGAP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[244]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[51]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[350]

Drug(s) Affected By Condensin-2 complex subunit G2 (NCAPG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[276]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[358]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[198]

Drug(s) Affected By Kinesin-like protein KIF18B (KIF18B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[281]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[51]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[410]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[289]

Drug(s) Affected By Spindle and kinetochore-associated protein 3 (SKA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[352]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[281]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[198]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]

Drug(s) Affected By Nurim (NRM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[281]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[423]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[410]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[425]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[209]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[350]

Drug(s) Affected By Rhotekin-2 (RTKN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[218]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[426]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[143]

Drug(s) Affected By Abnormal spindle-like microcephaly-associated protein (ASPM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[276]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[386]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]

Drug(s) Affected By Protein mono-ADP-ribosyltransferase PARP8 (PARP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[163]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[228]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[144]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[289]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[209]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[144]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[415]

Drug(s) Affected By Carboxypeptidase A6 (CPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[195]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[51]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[419]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[411]
OXYQUINOLINE	DMZVS9Y	Discovery agent	N.A.	Investigative	[143]
NAPQI	DM8F5LR	Autoimmune disease	4A40-4A45	Investigative	[427]

Drug(s) Affected By T-complex protein 11-like protein 2 (TCP11L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[121]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[198]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[218]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[228]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[428]

Drug(s) Affected By Leucine-rich repeat-containing protein 17 (LRRC17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[403]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[429]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[288]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[188]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[144]

Drug(s) Affected By Meiosis-specific nuclear structural protein 1 (MNS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[273]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[244]

Drug(s) Affected By SHC SH2 domain-binding protein 1 (SHCBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[363]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[198]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[273]

Drug(s) Affected By Spindle and kinetochore-associated protein 2 (SKA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[244]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[218]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[360]

Drug(s) Affected By Centromere protein I (CENPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[227]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[270]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[237]

Drug(s) Affected By Type II iodothyronine deiodinase (DIO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[430]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[431]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[432]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[253]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[433]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[434]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]

Drug(s) Affected By Histone H2B type 1-H (H2BC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[234]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[198]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[205]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[373]

Drug(s) Affected By F-box only protein 32 (FBXO32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[435]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[422]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[435]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[198]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[277]

Drug(s) Affected By Unconventional myosin-XIX (MYO19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[205]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[419]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[436]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[384]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[437]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[350]

Drug(s) Affected By 4-hydroxybenzoate polyprenyltransferase, mitochondrial (COQ2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[438]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[439]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[195]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[388]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[419]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[440]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[209]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[227]

Drug(s) Affected By Lymphokine-activated killer T-cell-originated protein kinase (PBK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[441]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]

Drug(s) Affected By Histone H2A type 1-H (H2AC12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[275]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[442]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[383]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[244]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[443]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[444]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[445]

Drug(s) Affected By Leucine-rich repeat protein 1 (LRR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[198]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[273]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[350]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[446]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[425]

Drug(s) Affected By Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 (PCMTD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[447]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[198]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[348]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[228]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[360]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[419]

Drug(s) Affected By ATPase family AAA domain-containing protein 5 (ATAD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[198]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[218]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[410]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[426]

Drug(s) Affected By Neuroserpin (SERPINI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[227]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[373]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[448]

Drug(s) Affected By Cell division cycle-associated protein 3 (CDCA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[283]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[227]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[358]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]

Drug(s) Affected By Cell division control protein 6 homolog (CDC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[112]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[449]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]

Drug(s) Affected By Condensin complex subunit 3 (NCAPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[358]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]

Drug(s) Affected By Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[435]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[450]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[451]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[283]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[450]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[452]

Drug(s) Affected By Acetyl-CoA acetyltransferase, cytosolic (ACAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[403]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[234]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[453]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[454]

Drug(s) Affected By Cell division cycle-associated protein 7 (CDCA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[216]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[417]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[227]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[455]

Drug(s) Affected By Meiotic nuclear division protein 1 homolog (MND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[371]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[227]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[198]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[273]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]

Drug(s) Affected By Fanconi anemia group J protein (BRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[283]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[227]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[237]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]

Drug(s) Affected By Fanconi anemia group D2 protein (FANCD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]

Drug(s) Affected By Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[403]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[456]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[74]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[457]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]

Drug(s) Affected By DNA replication factor Cdt1 (CDT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[227]

Drug(s) Affected By Phosducin-like protein 3 (PDCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[343]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[363]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[458]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[407]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[459]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[460]

Drug(s) Affected By Olfactory receptor 51B5 (OR51B5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[289]

Drug(s) Affected By Calcium-binding protein 39-like (CAB39L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[439]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[461]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[462]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[188]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[419]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[463]

Drug(s) Affected By Claspin (CLSPN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[227]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[121]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[244]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[218]

Drug(s) Affected By Lymphoid-specific helicase (HELLS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[281]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[227]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[198]

Drug(s) Affected By FIGNL1-interacting regulator of recombination and mitosis (FIRRM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[198]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[273]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[423]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[361]

Drug(s) Affected By Fanconi anemia group I protein (FANCI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[363]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[423]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[358]

Drug(s) Affected By G2 and S phase-expressed protein 1 (GTSE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[283]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[464]

Drug(s) Affected By Placenta-specific gene 8 protein (PLAC8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[465]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[163]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[419]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[466]

Drug(s) Affected By Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[467]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[429]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[361]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[420]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[289]

Drug(s) Affected By Phospholipid-transporting ATPase VD (ATP10D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[218]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[360]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[468]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[419]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[360]

Drug(s) Affected By 7-dehydrocholesterol reductase (DHCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[469]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[231]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[403]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[234]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[91]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[400]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[185]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[275]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[423]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[227]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[467]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[470]

Drug(s) Affected By Transgelin-3 (TAGLN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[234]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[221]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[221]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[471]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[472]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[419]

Drug(s) Affected By Cell cycle progression protein 1 (CCPG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[370]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[143]
Bortezomib	DMNO38U	Leukemia		Approved	[370]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]

Drug(s) Affected By Protein timeless homolog (TIMELESS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[223]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[198]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]

Drug(s) Affected By Transferrin receptor protein 2 (TFR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[473]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[410]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[289]
KENPAULLONE	DMAGVXW	Discovery agent	N.A.	Patented	[474]
Dorsomorphin	DMKYXJW	Discovery agent	N.A.	Investigative	[474]
SU9516	DMQHG0R	Discovery agent	N.A.	Investigative	[474]

Drug(s) Affected By DNA replication complex GINS protein PSF2 (GINS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[423]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[358]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]

Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[343]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[261]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[475]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[476]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[477]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[478]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[414]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[479]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[94]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[315]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[480]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[481]
Selenium	DM25CGV	N. A.	N. A.	Approved	[300]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[331]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[482]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[483]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]

Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[314]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[484]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[485]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[486]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[477]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[487]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[488]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[489]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[394]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[490]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[491]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[492]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[493]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[494]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[495]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[496]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[497]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[498]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[94]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[204]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[499]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[279]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[309]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[225]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[500]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[501]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[502]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[503]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[504]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[504]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[505]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[278]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[506]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[507]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[508]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[255]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[509]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[257]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Selenium	DM25CGV	N. A.	N. A.	Approved	[510]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[511]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[512]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[261]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[513]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[514]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[515]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[516]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[48]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[517]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[518]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[519]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[327]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[508]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[520]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[94]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[95]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[278]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[521]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[522]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[320]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[523]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[524]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[525]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[526]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[527]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[482]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[528]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[529]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[196]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[530]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[531]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[532]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[533]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[534]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[535]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[536]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[537]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[538]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[303]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[539]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[540]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[308]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[541]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[542]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[493]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[543]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[544]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[545]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[546]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[547]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[548]

Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[549]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[550]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[551]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[552]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[553]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[554]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[555]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[556]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[518]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[557]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[558]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[170]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[559]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[560]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[561]

Drug(s) Affected By Protein jagged-1 (JAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[562]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[563]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[552]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[198]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[343]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[564]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[168]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[557]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[565]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[566]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[567]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[568]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[343]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[327]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[115]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[523]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[569]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[570]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[196]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[571]

Drug(s) Affected By Neurogenic locus notch homolog protein 2 (NOTCH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[572]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[467]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[552]
Bortezomib	DMNO38U	Leukemia		Approved	[237]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[373]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[228]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[351]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[423]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[513]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[548]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[517]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[573]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[557]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[278]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[574]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[111]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[496]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[575]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[170]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[576]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[261]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[577]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[578]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[519]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[573]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[579]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[340]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[580]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[306]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[309]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[573]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[581]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[582]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[583]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[584]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[585]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[343]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[586]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[587]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[170]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[560]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[588]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[509]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[94]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[589]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[80]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[590]

Drug(s) Affected By Protein jagged-2 (JAG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[591]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[422]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[552]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[195]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[592]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[419]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[425]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[593]

Drug(s) Affected By Nuclear migration protein nudC (NUDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[384]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[178]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[463]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[289]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[384]

Drug(s) Affected By Succinate--CoA ligase subunit beta, mitochondrial (SUCLG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[345]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[387]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[388]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[368]

Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[278]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[506]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[594]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]

Drug(s) Affected By Large ribosomal subunit protein P2 (RPLP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[422]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[595]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[596]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[429]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[597]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[426]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[289]

Drug(s) Affected By Proteasome subunit alpha type-3 (PSMA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[234]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[470]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[195]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[218]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[598]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[360]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[426]

Drug(s) Affected By Heat shock 70 kDa protein 4 (HSPA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[599]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[204]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[600]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]

Drug(s) Affected By F-box only protein 41 (FBXO41)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[468]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[244]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[419]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[374]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[289]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[440]

Drug(s) Affected By Tropomyosin alpha-3 chain (TPM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[403]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[601]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[407]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[602]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[602]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[603]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[221]

Drug(s) Affected By Small ribosomal subunit protein eS21 (RPS21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[604]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[605]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[429]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[440]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[606]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[607]

Drug(s) Affected By 10 kDa heat shock protein, mitochondrial (HSPE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[608]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[280]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[71]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[280]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[596]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[609]

Drug(s) Affected By Myosin light polypeptide 6 (MYL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[371]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[244]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[205]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[429]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[610]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[428]

Drug(s) Affected By ATP synthase subunit e, mitochondrial (ATP5ME)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[363]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[385]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Indomethacin	DMSC4A7	Bursitis		Approved	[611]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[388]

Drug(s) Affected By SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[200]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[373]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[360]

Drug(s) Affected By ATP synthase subunit g, mitochondrial (ATP5MG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[385]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[612]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[613]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[614]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[289]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[440]

Drug(s) Affected By Tropomyosin alpha-1 chain (TPM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[363]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[506]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[612]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[414]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[387]
Bortezomib	DMNO38U	Leukemia		Approved	[237]

Drug(s) Affected By Splicing factor 3A subunit 3 (SF3A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[225]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[200]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[423]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[289]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[384]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[615]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[616]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 7 (ADAM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[289]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[617]

Drug(s) Affected By Heat shock protein beta-1 (HSPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[588]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[618]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[619]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[620]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[281]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[621]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[360]

Drug(s) Affected By Diablo IAP-binding mitochondrial protein (DIABLO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[588]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[363]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[170]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[622]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[306]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[623]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[624]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[281]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[423]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]

Drug(s) Affected By Protein S100-A10 (S100A10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[625]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[626]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[627]

Drug(s) Affected By ATP synthase subunit beta, mitochondrial (ATP5F1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[564]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[506]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[628]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[567]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[399]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[567]

Drug(s) Affected By Mirror-image polydactyly gene 1 protein (MIPOL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[214]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[447]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[423]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[419]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[119]

Drug(s) Affected By Tropomyosin alpha-4 chain (TPM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[629]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[143]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[630]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein K (HNRNPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[384]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[631]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[632]
Haloperidol	DM96SE0	Delirium		Approved	[407]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[612]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[399]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[633]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[632]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 2 (NDUFA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[634]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[388]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[429]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[635]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[440]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[636]

Drug(s) Affected By Cytochrome b5 type B (CYB5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[244]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[200]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[373]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[351]

Drug(s) Affected By Ran-specific GTPase-activating protein (RANBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[403]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[400]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[637]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[637]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[145]

Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[503]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[638]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[368]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[639]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[322]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[322]
Methyldopa	DM5I621	Hypertension	BA00-BA04	Approved	[640]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[197]

Drug(s) Affected By 26S proteasome regulatory subunit 6A (PSMC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[345]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[407]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[407]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[244]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[350]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein F (HNRNPF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[634]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[641]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[642]
ACYLINE	DM9GRTK	Prostate cancer	2C82.0	Phase 2	[643]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[426]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[289]

Drug(s) Affected By Tumor protein D54 (TPD52L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[644]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[634]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[215]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[645]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[646]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[384]

Drug(s) Affected By Pappalysin-1 (PAPPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[286]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[387]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[647]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[648]

Drug(s) Affected By Ras-related protein Rab-15 (RAB15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[286]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[457]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[649]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[642]

Drug(s) Affected By Heat shock protein 105 kDa (HSPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[435]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[650]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[235]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[2]
Multidrug resistance-associated protein 1 (ABCC1)	DTSYQGK	MRP1_HUMAN	Substrate	[3]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[4]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Glutathione S-transferase alpha-1 (GSTA1) Main DME	DE4ZHS1	GSTA1_HUMAN	Substrate	[5]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
10 kDa heat shock protein, mitochondrial (HSPE1)	OT7JSZLB	CH10_HUMAN	Drug Response	[6]
14-3-3 protein beta/alpha	OTGBS3RF	1433B_HUMAN	Drug Response	[6]
14-3-3 protein epsilon	OT3WQXNA	1433E_HUMAN	Drug Response	[6]
14-3-3 protein eta	OTP8NJFJ	1433F_HUMAN	Drug Response	[6]
14-3-3 protein theta	OTWG7F3H	1433T_HUMAN	Drug Response	[6]
14-3-3 protein zeta/delta	OT2TKG9P	1433Z_HUMAN	Drug Response	[6]
26S proteasome regulatory subunit 6A (PSMC3)	OTSKT0JI	PRS6A_HUMAN	Drug Response	[6]
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP)	OTSMGKXQ	EBP_HUMAN	Gene/Protein Processing	[7]
4-hydroxybenzoate polyprenyltransferase, mitochondrial (COQ2)	OTDAKEY4	COQ2_HUMAN	Gene/Protein Processing	[7]
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2)	OTLVN68B	AAKB2_HUMAN	Gene/Protein Processing	[7]

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