Details of the Drug Combination

General Information of Drug Combination (ID: DCTL892)

Drug Combination Name
Rosiglitazone Cabozantinib
Indication
Disease Entry Status REF
Papillary Thyroid Cancer Phase 1 [1]
Component Drugs Rosiglitazone   DMILWZR Cabozantinib   DMIYDT4
N.A. Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Rosiglitazone
Disease Entry ICD 11 Status REF
Chronic kidney disease GB61 Terminated []
Rosiglitazone Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [11]
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Rosiglitazone Interacts with 4 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [12]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [13]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [13]
Prostaglandin G/H synthase 1 (COX-1) DE073H6 PGH1_HUMAN Metabolism [14]
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Rosiglitazone Interacts with 589 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Increases Expression [15]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases Expression [16]
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Decreases Activity [16]
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Increases Expression [16]
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1) OTZKVLVJ CP17A_HUMAN Decreases Activity [17]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2) OT02MSKN 3BHS2_HUMAN Decreases Activity [17]
Retinoic acid receptor beta (RARB) OT367U3E RARB_HUMAN Increases Expression [18]
Liver carboxylesterase 1 (CES1) OT9L0LR8 EST1_HUMAN Increases Expression [19]
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) OTJC60Q7 THIL_HUMAN Decreases Expression [19]
Perilipin-2 (PLIN2) OTRXJ9UN PLIN2_HUMAN Increases Expression [19]
Choriogonadotropin subunit beta 3 (CGB3) OTVM2SU3 CGB3_HUMAN Increases Expression [20]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Increases Expression [21]
Apolipoprotein E (APOE) OTFOWL2H APOE_HUMAN Increases Expression [21]
Scavenger receptor class B member 1 (SCARB1) OTAE1UA1 SCRB1_HUMAN Increases Expression [21]
Golgin subfamily A member 8A (GOLGA8A) OTSNE9EQ GOG8A_HUMAN Decreases Expression [4]
CMRF35-like molecule 7 (CD300LB) OTVC407Y CLM7_HUMAN Increases Expression [4]
Signal-regulatory protein beta-1 (SIRPB1) OTGHALWJ SIRB1_HUMAN Increases Expression [4]
Regulatory factor X-associated protein (RFXAP) OTX46DKQ RFXAP_HUMAN Decreases Expression [4]
Agrin (AGRN) OTWJENAZ AGRIN_HUMAN Decreases Expression [4]
Phospholipid phosphatase 3 (PLPP3) OTSSF7BK PLPP3_HUMAN Increases Expression [4]
Low-density lipoprotein receptor class A domain-containing protein 4 (LDLRAD4) OTQUX50Z LRAD4_HUMAN Increases Expression [4]
Tumor necrosis factor ligand superfamily member 12 (TNFSF12) OT6FQ02V TNF12_HUMAN Decreases Expression [4]
F-box-like/WD repeat-containing protein TBL1X (TBL1X) OTXQ51E0 TBL1X_HUMAN Decreases Expression [4]
Leukocyte immunoglobulin-like receptor subfamily A member 1 (LILRA1) OTZ4NA7Q LIRA1_HUMAN Increases Expression [4]
Short-chain dehydrogenase/reductase 3 (DHRS3) OTSK1DTP DHRS3_HUMAN Increases Expression [4]
Retinal dehydrogenase 2 (ALDH1A2) OTJB560Z AL1A2_HUMAN Increases Expression [4]
Rho-related BTB domain-containing protein 3 (RHOBTB3) OT1BFKPH RHBT3_HUMAN Increases Expression [4]
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2) OTDLEXPN PAPS2_HUMAN Increases Expression [4]
Mitogen-activated protein kinase kinase kinase 6 (MAP3K6) OTOE0Z1R M3K6_HUMAN Decreases Expression [4]
BAG family molecular chaperone regulator 2 (BAG2) OTI6LD27 BAG2_HUMAN Increases Expression [4]
Adenosine deaminase (ADA) OTOX2872 ADA_HUMAN Increases Expression [4]
T-cell surface glycoprotein CD1a (CD1A) OTKSSG6N CD1A_HUMAN Decreases Expression [4]
Beta-glucuronidase (GUSB) OT9N1DK3 BGLR_HUMAN Increases Expression [4]
Retinol-binding protein 1 (RBP1) OTRP1MFC RET1_HUMAN Increases Expression [4]
Tumor-associated calcium signal transducer 2 (TACSTD2) OTLSZR00 TACD2_HUMAN Decreases Expression [4]
Peroxisomal coenzyme A diphosphatase NUDT7 (NUDT7) OTCPOQ6W NUDT7_HUMAN Decreases Expression [4]
Interleukin-1 receptor type 1 (IL1R1) OTTU8959 IL1R1_HUMAN Decreases Expression [4]
Protein C-ets-2 (ETS2) OTPVHOZ7 ETS2_HUMAN Increases Expression [4]
Antigen-presenting glycoprotein CD1d (CD1D) OT3ROU4J CD1D_HUMAN Increases Expression [4]
Plasma membrane calcium-transporting ATPase 1 (ATP2B1) OT5MXG9W AT2B1_HUMAN Decreases Expression [4]
Protein-glutamine gamma-glutamyltransferase 2 (TGM2) OT6MFOWF TGM2_HUMAN Increases Expression [4]
Collagen alpha-3(V) chain (COL5A3) OTCGC4DM CO5A3_HUMAN Increases Expression [4]
Integrin alpha-E (ITGAE) OT41KCRX ITAE_HUMAN Increases Expression [4]
Rap1 GTPase-activating protein 1 (RAP1GAP) OTC31ONQ RPGP1_HUMAN Decreases Expression [4]
Nuclear receptor-interacting protein 1 (NRIP1) OTIZOJQV NRIP1_HUMAN Increases Expression [4]
Ribose-5-phosphate isomerase (RPIA) OT805SMH RPIA_HUMAN Increases Expression [4]
Thrombospondin-3 (THBS3) OTDKMUBD TSP3_HUMAN Increases Expression [4]
PDZ and LIM domain protein 4 (PDLIM4) OT23LZYY PDLI4_HUMAN Decreases Expression [4]
Histone H2B type 1-D (H2BC5) OTXDTDHN H2B1D_HUMAN Decreases Expression [4]
Ras-related protein Rab-15 (RAB15) OTU0GGR3 RAB15_HUMAN Decreases Expression [4]
Oxidized low-density lipoprotein receptor 1 (OLR1) OTS44RIC OLR1_HUMAN Increases Expression [4]
Amyloid beta precursor like protein 2 (APLP2) OTTFE53M APLP2_HUMAN Increases Expression [4]
Myotonin-protein kinase (DMPK) OT9XJKG4 DMPK_HUMAN Decreases Expression [4]
Dystrophia myotonica WD repeat-containing protein (DMWD) OT0CBZ6F DMWD_HUMAN Decreases Expression [4]
Alpha-(1,3)-fucosyltransferase 7 (FUT7) OTJF6BSN FUT7_HUMAN Decreases Expression [4]
P-selectin glycoprotein ligand 1 (SELPLG) OTOK3301 SELPL_HUMAN Decreases Expression [4]
H2.0-like homeobox protein (HLX) OT7DTH46 HLX_HUMAN Decreases Expression [4]
Uncharacterized protein KIAA0040 (KIAA0040) OT27EBY3 K0040_HUMAN Decreases Expression [4]
Serum paraoxonase/arylesterase 2 (PON2) OT55NCTD PON2_HUMAN Decreases Expression [4]
Nicotinate-nucleotide pyrophosphorylase (QPRT) OT6SKKLL NADC_HUMAN Decreases Expression [4]
Calcitonin gene-related peptide type 1 receptor (CALCRL) OTMGGM47 CALRL_HUMAN Decreases Expression [4]
Zinc finger protein SNAI3 (SNAI3) OTG9DI66 SNAI3_HUMAN Increases Expression [4]
Pleckstrin homology-like domain family A member 2 (PHLDA2) OTMV9DPP PHLA2_HUMAN Decreases Expression [4]
Late cornified envelope-like proline-rich protein 1 (LELP1) OTOQIVV0 LELP1_HUMAN Decreases Expression [4]
Protein sel-1 homolog 3 (SEL1L3) OT10N6Z2 SE1L3_HUMAN Increases Expression [4]
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) OTXIGC6I LAIR1_HUMAN Increases Expression [4]
Myogenesis-regulating glycosidase (MYORG) OTVK4VMH MYORG_HUMAN Decreases Expression [4]
Uncharacterized protein C16orf46 (C16ORF46) OT8FDG3A CP046_HUMAN Decreases Expression [4]
Phospholipase B-like 1 (PLBD1) OTHYEB4W PLBL1_HUMAN Increases Expression [4]
Low-density lipoprotein receptor-related protein 11 (LRP11) OTQNI7L8 LRP11_HUMAN Decreases Expression [4]
Sodium-independent sulfate anion transporter (SLC26A11) OTWBV9CR S2611_HUMAN Increases Expression [4]
Cerebellar degeneration-related protein 2-like (CDR2L) OT5UVB1J CDR2L_HUMAN Decreases Expression [4]
SLIT and NTRK-like protein 4 (SLITRK4) OTSCN5AM SLIK4_HUMAN Increases Expression [4]
Retinol dehydrogenase 10 (RDH10) OTL9FSGF RDH10_HUMAN Increases Expression [4]
Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1L) OTVLWW9T GPD1L_HUMAN Decreases Expression [4]
Sesquipedalian-1 (PHETA1) OT4IMC0X SESQ1_HUMAN Decreases Expression [4]
Refilin-B (RFLNB) OTI7ZM75 RFLB_HUMAN Increases Expression [4]
Uncharacterized protein FAM241A (FAM241A) OTC12ETA F241A_HUMAN Decreases Expression [4]
F-box only protein 15 (FBXO15) OTJHEFE5 FBX15_HUMAN Increases Expression [4]
RalBP1-associated Eps domain-containing protein 2 (REPS2) OTSE3TRP REPS2_HUMAN Decreases Expression [4]
CMRF35-like molecule 1 (CD300LF) OTQWJGSR CLM1_HUMAN Increases Expression [4]
Serine-rich single-pass membrane protein 1 (SSMEM1) OTH78CH0 SSMM1_HUMAN Decreases Expression [4]
Interactor protein for cytohesin exchange factors 1 (IPCEF1) OTOUIHID ICEF1_HUMAN Decreases Expression [4]
Cortactin-binding protein 2 (CTTNBP2) OT4CL1EW CTTB2_HUMAN Decreases Expression [4]
Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1) OT6FQ1K3 M4K1_HUMAN Decreases Expression [4]
Kinesin-like protein KIFC2 (KIFC2) OTLTVM7V KIFC2_HUMAN Decreases Expression [4]
Metalloendopeptidase OMA1, mitochondrial (OMA1) OT0JRVY7 OMA1_HUMAN Increases Expression [4]
PDZ and LIM domain protein 2 (PDLIM2) OTEURRPD PDLI2_HUMAN Decreases Expression [4]
Fatty acyl-CoA reductase 2 (FAR2) OTRYY709 FACR2_HUMAN Increases Expression [4]
PML-RARA-regulated adapter molecule 1 (PRAM1) OTZN3DWD PRAM_HUMAN Increases Expression [4]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [4]
Dehydrogenase/reductase SDR family member 9 (DHRS9) OTB1WOZA DHRS9_HUMAN Increases Expression [4]
Caspase recruitment domain-containing protein 14 (CARD14) OTADQHOV CAR14_HUMAN Increases Expression [4]
TBC1 domain family member 2A (TBC1D2) OTSGHPD0 TBD2A_HUMAN Increases Expression [4]
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4 (B3GNT4) OTRKV2N8 B3GN4_HUMAN Increases Expression [4]
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) OT4U7SBG GBRL1_HUMAN Increases Expression [4]
Dendritic cell-specific transmembrane protein (DCSTAMP) OTFKRP2H DCSTP_HUMAN Increases Expression [4]
Homeodomain-interacting protein kinase 2 (HIPK2) OTDB7QC3 HIPK2_HUMAN Increases Expression [4]
Ribokinase (RBKS) OTDG01Y9 RBSK_HUMAN Increases Expression [4]
Tensin-1 (TNS1) OTZ8S1PL TENS1_HUMAN Decreases Expression [4]
Echinoderm microtubule-associated protein-like 4 (EML4) OTJC45TA EMAL4_HUMAN Increases Expression [4]
Interleukin-1 receptor accessory protein (IL1RAP) OTEU321R IL1AP_HUMAN Decreases Expression [4]
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (MAN1C1) OT44TM7D MA1C1_HUMAN Decreases Expression [4]
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4) OT5CTQKO PLCD_HUMAN Increases Expression [4]
Ras-related protein Rab-20 (RAB20) OTP9OOVS RAB20_HUMAN Increases Expression [4]
ETS homologous factor (EHF) OTY6TPWD EHF_HUMAN Increases Expression [4]
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (MGAT4C) OTQ2R629 MGT4C_HUMAN Decreases Expression [4]
DnaJ homolog subfamily C member 5B (DNAJC5B) OTHDMM7O DNJ5B_HUMAN Increases Expression [4]
CMRF35-like molecule 8 (CD300A) OTGBQE0Z CLM8_HUMAN Increases Expression [4]
Meteorin (METRN) OTI2645G METRN_HUMAN Decreases Expression [4]
Adherens junction-associated protein 1 (AJAP1) OTAAW121 AJAP1_HUMAN Increases Expression [4]
Paladin (PALD1) OTLGUM8H PALD_HUMAN Decreases Expression [4]
Protein NDRG2 (NDRG2) OT5L6KD7 NDRG2_HUMAN Decreases Expression [4]
Phosphatidylinositide phosphatase SAC2 (INPP5F) OTPKUY50 SAC2_HUMAN Increases Expression [4]
Transducin beta-like protein 2 (TBL2) OTCIMSK8 TBL2_HUMAN Increases Expression [4]
Transmembrane protein 14A (TMEM14A) OTANQA6G TM14A_HUMAN Decreases Expression [4]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Increases Expression [22]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Decreases Expression [22]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Decreases Expression [22]
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1) OTO7FJA9 DHI1_HUMAN Decreases Expression [22]
Lipid transferase CIDEC (CIDEC) OTMDZ56K CIDEC_HUMAN Increases Expression [22]
Resistin (RETN) OTW5Z1NH RETN_HUMAN Decreases Expression [22]
Proline dehydrogenase 1, mitochondrial (PRODH) OT7SQ1C7 PROD_HUMAN Increases Expression [23]
Catalase (CAT) OTHEBX9R CATA_HUMAN Increases Expression [24]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Decreases Expression [25]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Expression [25]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [26]
Amine oxidase A (MAOA) OT8NIWMQ AOFA_HUMAN Decreases Activity [27]
Amine oxidase B (MAOB) OTTDFM1O AOFB_HUMAN Decreases Activity [27]
Cytochrome P450 2J2 (CYP2J2) OTJBTEH8 CP2J2_HUMAN Increases Expression [28]
Cytochrome c oxidase subunit 1 (COX1) OTG3O9BN COX1_HUMAN Increases Expression [29]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Increases Expression [29]
Succinate dehydrogenase flavoprotein subunit, mitochondrial (SDHA) OTOJ8QFF SDHA_HUMAN Increases Expression [29]
Transcription factor A, mitochondrial (TFAM) OTXXV5V7 TFAM_HUMAN Increases Expression [29]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Increases Expression [29]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [30]
Fucose mutarotase (FUOM) OTM201HH FUCM_HUMAN Decreases Expression [5]
Myotubularin-related protein 11 (MTMR11) OTHL2O08 MTMRB_HUMAN Decreases Expression [5]
Aspartate dehydrogenase domain-containing protein (ASPDH) OTN38YBY ASPDH_HUMAN Decreases Expression [5]
D-dopachrome decarboxylase-like protein (DDTL) OTG1LU87 DDTL_HUMAN Decreases Expression [5]
Espin (ESPN) OT7Z6LX2 ESPN_HUMAN Decreases Expression [5]
Mannan-binding lectin serine protease 2 (MASP2) OTBFTUZ1 MASP2_HUMAN Decreases Expression [5]
Sodium/nucleoside cotransporter 1 (SLC28A1) OTXWVV9O S28A1_HUMAN Decreases Expression [5]
Matrilin-2 (MATN2) OTVDR68G MATN2_HUMAN Decreases Expression [5]
Phospholipid phosphatase 1 (PLPP1) OT0IIMI5 PLPP1_HUMAN Increases Expression [5]
Kynurenine 3-monooxygenase (KMO) OT3MRMM9 KMO_HUMAN Decreases Expression [5]
Solute carrier family 22 member 1 (SLC22A1) OT7817I4 S22A1_HUMAN Decreases Expression [5]
Calpain-5 (CAPN5) OTQ8QM7K CAN5_HUMAN Decreases Expression [5]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Decreases Expression [5]
Protein MTSS 1 (MTSS1) OT5DTDO2 MTSS1_HUMAN Decreases Expression [5]
Synaptotagmin-7 (SYT7) OTBWAOWY SYT7_HUMAN Decreases Expression [5]
Glucose-6-phosphate exchanger SLC37A4 (SLC37A4) OTLCYA32 G6PT1_HUMAN Decreases Expression [5]
Perilipin-1 (PLIN1) OT3OAAZ4 PLIN1_HUMAN Increases Expression [5]
Peroxisomal membrane protein 11A (PEX11A) OT8MJ9CJ PX11A_HUMAN Increases Expression [5]
Tumor necrosis factor receptor superfamily member 21 (TNFRSF21) OT3EDGXO TNR21_HUMAN Increases Expression [5]
Lathosterol oxidase (SC5D) OT41KMW4 SC5D_HUMAN Decreases Expression [5]
Organic cation/carnitine transporter 2 (SLC22A5) OTC36TYB S22A5_HUMAN Increases Expression [5]
ABC-type organic anion transporter ABCA8 (ABCA8) OTCWLX6N ABCA8_HUMAN Decreases Expression [5]
ATP-binding cassette sub-family C member 6 (ABCC6) OTZT0LKT MRP6_HUMAN Decreases Expression [5]
Ornithine transcarbamylase, mitochondrial (OTC) OTJ57GGA OTC_HUMAN Decreases Expression [5]
Coagulation factor X (F10) OT2BLK17 FA10_HUMAN Decreases Expression [5]
Coagulation factor XII (F12) OTBFD2FU FA12_HUMAN Decreases Expression [5]
Complement factor B (CFB) OTZITNEJ CFAB_HUMAN Decreases Expression [5]
Serine protease inhibitor Kazal-type 1 (SPINK1) OTSUVAL2 ISK1_HUMAN Increases Expression [5]
HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA) OT7KZMP2 DRA_HUMAN Decreases Expression [5]
Plasma kallikrein (KLKB1) OTGSEISX KLKB1_HUMAN Decreases Expression [5]
Vitamin K-dependent protein C (PROC) OTGVH484 PROC_HUMAN Decreases Expression [5]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Increases Expression [5]
Glycophorin-C (GYPC) OTOEDR7O GLPC_HUMAN Increases Expression [5]
Fructose-bisphosphate aldolase B (ALDOB) OT7FR69A ALDOB_HUMAN Decreases Expression [5]
Arginase-1 (ARG1) OTHZITAM ARGI1_HUMAN Decreases Expression [5]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Increases Expression [5]
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL) OTG7J4BP PPBT_HUMAN Decreases Expression [5]
Serine protease hepsin (HPN) OT7QNA61 HEPS_HUMAN Decreases Expression [5]
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Decreases Expression [5]
Cholinesterase (BCHE) OTOH3WQ9 CHLE_HUMAN Decreases Expression [5]
Apolipoprotein A-IV (APOA4) OT466POQ APOA4_HUMAN Decreases Expression [5]
Asialoglycoprotein receptor 2 (ASGR2) OTFSGOVY ASGR2_HUMAN Decreases Expression [5]
Complement component C8 alpha chain (C8A) OTIJ65J4 CO8A_HUMAN Decreases Expression [5]
Complement component C8 beta chain (C8B) OTGDJJOK CO8B_HUMAN Decreases Expression [5]
Complement component C8 gamma chain (C8G) OTZM027I CO8G_HUMAN Decreases Expression [5]
All-trans-retinol dehydrogenase ADH4 (ADH4) OTKDKKNG ADH4_HUMAN Decreases Expression [5]
Complement factor H (CFH) OTAGKQTJ CFAH_HUMAN Decreases Expression [5]
Coagulation factor VII (F7) OTGNJ97M FA7_HUMAN Decreases Expression [5]
Mannose-binding protein C (MBL2) OTS63HG5 MBL2_HUMAN Increases Expression [5]
Cytochrome P450 2A6 (CYP2A6) OT52TWG3 CP2A6_HUMAN Decreases Expression [5]
Nucleoprotein TPR (TPR) OTUBBA4W TPR_HUMAN Decreases Expression [5]
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1) OTQY6ZSF HEM1_HUMAN Increases Expression [5]
D-amino-acid oxidase (DAO) OTZFVRIN OXDA_HUMAN Decreases Expression [5]
Carboxypeptidase N catalytic chain (CPN1) OTKXIFI6 CBPN_HUMAN Decreases Expression [5]
Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) OT7US3NO SIAT1_HUMAN Decreases Expression [5]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (PFKFB1) OTTHX4NB F261_HUMAN Decreases Expression [5]
NADPH--cytochrome P450 reductase (POR) OTVIDOCH NCPR_HUMAN Increases Expression [5]
Insulin-like growth factor-binding protein 2 (IGFBP2) OTG1P60E IBP2_HUMAN Decreases Expression [5]
Cytochrome P450 2A7 (CYP2A7) OTRJ3P2Z CP2A7_HUMAN Decreases Expression [5]
5'-nucleotidase (NT5E) OT7J5LT6 5NTD_HUMAN Decreases Expression [5]
Sterol carrier protein 2 (SCP2) OTPAFCPQ SCP2_HUMAN Decreases Expression [5]
Fibroblast growth factor receptor 3 (FGFR3) OTSAXDIL FGFR3_HUMAN Decreases Expression [5]
Cytochrome P450 7A1 (CYP7A1) OT8Z5KLD CP7A1_HUMAN Decreases Expression [5]
Arylacetamide deacetylase (AADAC) OT8VACT2 AAAD_HUMAN Increases Expression [5]
Vitamin K-dependent protein Z (PROZ) OTI3TXBE PROZ_HUMAN Decreases Expression [5]
Receptor-type tyrosine-protein phosphatase epsilon (PTPRE) OTOD5NID PTPRE_HUMAN Increases Expression [5]
Plasma membrane calcium-transporting ATPase 4 (ATP2B4) OTMWFDAC AT2B4_HUMAN Increases Expression [5]
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Decreases Expression [5]
Serum paraoxonase/arylesterase 1 (PON1) OTD0Z2XO PON1_HUMAN Decreases Expression [5]
G0/G1 switch protein 2 (G0S2) OT8FL49L G0S2_HUMAN Decreases Expression [5]
Alcohol dehydrogenase 6 (ADH6) OTS7DYH9 ADH6_HUMAN Decreases Expression [5]
Proprotein convertase subtilisin/kexin type 6 (PCSK6) OTI64BU4 PCSK6_HUMAN Decreases Expression [5]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Decreases Expression [5]
Kallistatin (SERPINA4) OTBK0GG7 KAIN_HUMAN Decreases Expression [5]
D-dopachrome decarboxylase (DDT) OTF5HTYL DOPD_HUMAN Decreases Expression [5]
GTP cyclohydrolase 1 feedback regulatory protein (GCHFR) OTEOT8GI GFRP_HUMAN Decreases Expression [5]
Pyruvate kinase PKLR (PKLR) OTTTM1QI KPYR_HUMAN Decreases Expression [5]
Carbamoyl-phosphate synthase , mitochondrial (CPS1) OTXV8NSR CPSM_HUMAN Decreases Expression [5]
Cystathionine gamma-lyase (CTH) OTC90LA0 CGL_HUMAN Decreases Expression [5]
CD70 antigen (CD70) OTHB2AL1 CD70_HUMAN Increases Expression [5]
Cytochrome P450 2C18 (CYP2C18) OTY687L9 CP2CI_HUMAN Decreases Expression [5]
Carbonic anhydrase 5A, mitochondrial (CA5A) OTP9M7VW CAH5A_HUMAN Decreases Expression [5]
Nuclear receptor ROR-alpha (RORA) OTGQT12P RORA_HUMAN Decreases Expression [5]
Cystathionine beta-synthase (CBS) OT46FSKD CBS_HUMAN Decreases Expression [5]
Glucose-6-phosphatase catalytic subunit 1 (G6PC1) OTJ6FM9F G6PC1_HUMAN Decreases Expression [5]
Pigment epithelium-derived factor (SERPINF1) OTWZH98J PEDF_HUMAN Decreases Expression [5]
Isoleucine--tRNA ligase, cytoplasmic (IARS1) OT9WXH5N SYIC_HUMAN Increases Expression [5]
Afamin (AFM) OTPOR8IO AFAM_HUMAN Decreases Expression [5]
5-hydroxytryptamine receptor 3A (HTR3A) OTAIV1AK 5HT3A_HUMAN Increases Expression [5]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Increases Expression [5]
Flavin-containing monooxygenase 5 (FMO5) OTTILF8T FMO5_HUMAN Decreases Expression [5]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) OTI862QH CPT1A_HUMAN Increases Expression [5]
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) OT714BUO AL3A2_HUMAN Increases Expression [5]
Stanniocalcin-1 (STC1) OTGVVXYF STC1_HUMAN Decreases Expression [5]
Trifunctional enzyme subunit beta, mitochondrial (HADHB) OT4Y1I62 ECHB_HUMAN Increases Expression [5]
Inhibin beta E chain (INHBE) OTOI2NYG INHBE_HUMAN Decreases Expression [5]
Large ribosomal subunit protein eL15 (RPL15) OT7Y42LL RL15_HUMAN Increases Expression [5]
Protein BTG1 (BTG1) OTVJ2CDM BTG1_HUMAN Decreases Expression [5]
Estrogen-related receptor gamma (ESRRG) OTC3A0KU ERR3_HUMAN Decreases Expression [5]
Cytochrome P450 4F2 (CYP4F2) OTKILAER CP4F2_HUMAN Decreases Expression [5]
T-complex protein 1 subunit beta (CCT2) OTW1VV4E TCPB_HUMAN Increases Expression [5]
Sushi repeat-containing protein SRPX (SRPX) OT5B9LXS SRPX_HUMAN Increases Expression [5]
4-aminobutyrate aminotransferase, mitochondrial (ABAT) OTXAGR7J GABT_HUMAN Decreases Expression [5]
Cytochrome c oxidase subunit 6A2, mitochondrial (COX6A2) OTQR5SXD CX6A2_HUMAN Decreases Expression [5]
Aminoacylase-1 (ACY1) OT9WU7X3 ACY1_HUMAN Decreases Expression [5]
Transcription factor SOX-4 (SOX4) OTSS40SS SOX4_HUMAN Increases Expression [5]
Follistatin-related protein 1 (FSTL1) OT6KEZUD FSTL1_HUMAN Increases Expression [5]
Secreted phosphoprotein 24 (SPP2) OTX254AR SPP24_HUMAN Decreases Expression [5]
Syntaxin-3 (STX3) OT4CIWLJ STX3_HUMAN Increases Expression [5]
Protein phosphatase 1 regulatory subunit 1A (PPP1R1A) OTGTAGCV PPR1A_HUMAN Decreases Expression [5]
Dihydropyrimidinase (DPYS) OTLTUIVL DPYS_HUMAN Decreases Expression [5]
SPARC-like protein 1 (SPARCL1) OT74DWMV SPRL1_HUMAN Decreases Expression [5]
Laminin subunit alpha-4 (LAMA4) OTHI7TA0 LAMA4_HUMAN Increases Expression [5]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Increases Expression [5]
Hydroxyacylglutathione hydrolase, mitochondrial (HAGH) OTYMDAYV GLO2_HUMAN Decreases Expression [5]
Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2) OTJ8LX4N PCKGM_HUMAN Decreases Expression [5]
BTB/POZ domain-containing protein 16 (BTBD16) OT04G9HG BTBDG_HUMAN Decreases Expression [5]
Triokinase/FMN cyclase (TKFC) OTTWXIOI TKFC_HUMAN Decreases Expression [5]
Ectonucleoside triphosphate diphosphohydrolase 8 (ENTPD8) OTB9GJ1V ENTP8_HUMAN Decreases Expression [5]
Kidney mitochondrial carrier protein 1 (SLC25A30) OT2VA5PI KMCP1_HUMAN Increases Expression [5]
Early estrogen-induced gene 1 protein (EEIG1) OT2BMEAE EEIG1_HUMAN Increases Expression [5]
Solute carrier family 22 member 10 (SLC22A10) OTUVJI3H S22AA_HUMAN Decreases Expression [5]
Acyl-coenzyme A synthetase ACSM5, mitochondrial (ACSM5) OTWMDQPX ACSM5_HUMAN Decreases Expression [5]
Iodotyrosine deiodinase 1 (IYD) OT8BQWTE IYD1_HUMAN Decreases Expression [5]
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4 (LINGO4) OTLADERJ LIGO4_HUMAN Decreases Expression [5]
Alkylglycerol monooxygenase (AGMO) OTGMAHAT ALKMO_HUMAN Decreases Expression [5]
Ras and Rab interactor-like protein (RINL) OTZ0NDKE RINL_HUMAN Increases Expression [5]
Hemojuvelin (HJV) OT4235J2 RGMC_HUMAN Decreases Expression [5]
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) OTSF2NXD SAMC_HUMAN Increases Expression [5]
Equilibrative nucleoside transporter 4 (SLC29A4) OTWTZXMX S29A4_HUMAN Increases Expression [5]
Transient receptor potential cation channel subfamily M member 8 (TRPM8) OT7ACGYK TRPM8_HUMAN Increases Expression [5]
L-xylulose reductase (DCXR) OTYVXRXB DCXR_HUMAN Decreases Expression [5]
Organic solute transporter subunit alpha (SLC51A) OTDJRZ0P OSTA_HUMAN Decreases Expression [5]
Organic solute transporter subunit beta (SLC51B) OT4WYPSR OSTB_HUMAN Increases Expression [5]
2-acylglycerol O-acyltransferase 3 (MOGAT3) OTPGLUBS MOGT3_HUMAN Decreases Expression [5]
Src kinase-associated phosphoprotein 1 (SKAP1) OTD4ZKAL SKAP1_HUMAN Decreases Expression [5]
Cell division cycle protein 20 homolog B (CDC20B) OTO5F8CF CD20B_HUMAN Decreases Expression [5]
Transmembrane protease serine 6 (TMPRSS6) OTA17R1M TMPS6_HUMAN Decreases Expression [5]
Organic anion transporter 7 (SLC22A9) OTO4BJCC S22A9_HUMAN Decreases Expression [5]
Volume-regulated anion channel subunit LRRC8A (LRRC8A) OT23OE7H LRC8A_HUMAN Decreases Expression [5]
Tumor protein p53-inducible nuclear protein 2 (TP53INP2) OT0GTBXO T53I2_HUMAN Decreases Expression [5]
Probable inactive peptidyl-prolyl cis-trans isomerase-like 6 (PPIL6) OTOZQMQE PPIL6_HUMAN Increases Expression [5]
NADH dehydrogenase 1 alpha subcomplex assembly factor 2 (NDUFAF2) OTC8QPRS NDUF2_HUMAN Increases Expression [5]
Lysoplasmalogenase TMEM86B (TMEM86B) OTOKL8BF TM86B_HUMAN Decreases Expression [5]
Interleukin-22 receptor subunit alpha-1 (IL22RA1) OTGVKLBR I22R1_HUMAN Decreases Expression [5]
Sodium-dependent lysophosphatidylcholine symporter 1 (MFSD2A) OTVG1VG0 NLS1_HUMAN Decreases Expression [5]
Mixed lineage kinase domain-like protein (MLKL) OTDSLC81 MLKL_HUMAN Increases Expression [5]
Clarin-3 (CLRN3) OTZDNL65 CLRN3_HUMAN Decreases Expression [5]
Phosphatidylinositol 4-kinase type 2-beta (PI4K2B) OT0D51QP P4K2B_HUMAN Decreases Expression [5]
Serine/threonine-protein kinase BRSK1 (BRSK1) OT6N35Q0 BRSK1_HUMAN Decreases Expression [5]
Transmembrane protein 171 (TMEM171) OTJPHOWW TM171_HUMAN Increases Expression [5]
Thyroid hormone-inducible hepatic protein (THRSP) OTKYE01L THRSP_HUMAN Decreases Expression [5]
Retinol dehydrogenase 5 (RDH5) OTYBZHCC RDH5_HUMAN Decreases Expression [5]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Increases Expression [5]
Proteoglycan 4 (PRG4) OT34NR3N PRG4_HUMAN Decreases Expression [5]
Solute carrier organic anion transporter family member 2A1 (SLCO2A1) OT3062CA SO2A1_HUMAN Increases Expression [5]
Liver-expressed antimicrobial peptide 2 (LEAP2) OTUOPIS5 LEAP2_HUMAN Decreases Expression [5]
Interferon-stimulated gene 20 kDa protein (ISG20) OTCWRJJW ISG20_HUMAN Decreases Expression [5]
GTP-binding protein Rhes (RASD2) OTETA815 RHES_HUMAN Increases Expression [5]
FXYD domain-containing ion transport regulator 5 (FXYD5) OT81DIOD FXYD5_HUMAN Increases Expression [5]
Endoplasmic reticulum resident protein 27 (ERP27) OTVMGE2H ERP27_HUMAN Decreases Expression [5]
E3 ubiquitin-protein ligase RNF125 (RNF125) OTBD1Q3X RN125_HUMAN Decreases Expression [5]
Uncharacterized protein C11orf24 (C11ORF24) OT2DOJ6E CK024_HUMAN Decreases Expression [5]
Calmodulin-like protein 4 (CALML4) OT6DD5EW CALL4_HUMAN Decreases Expression [5]
Transmembrane protein 41A (TMEM41A) OTAAULKY TM41A_HUMAN Decreases Expression [5]
SH2 domain-containing adapter protein D (SHD) OTGTHL5V SHD_HUMAN Decreases Expression [5]
Membrane-spanning 4-domains subfamily A member 10 (MS4A10) OTH3LAUX M4A10_HUMAN Decreases Expression [5]
Serine protease FAM111A (FAM111A) OTVLARLG F111A_HUMAN Decreases Expression [5]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Decreases Expression [5]
Serine incorporator 2 (SERINC2) OTZ039U0 SERC2_HUMAN Increases Expression [5]
G-protein coupled estrogen receptor 1 (GPER1) OTUK0TDC GPER1_HUMAN Decreases Expression [5]
Sodium-coupled neutral amino acid transporter 3 (SLC38A3) OTCHH25G S38A3_HUMAN Decreases Expression [5]
Iron-sulfur cluster assembly 1 homolog, mitochondrial (ISCA1) OTU230MC ISCA1_HUMAN Increases Expression [5]
Guanine nucleotide-binding protein-like 3 (GNL3) OTILGYO4 GNL3_HUMAN Increases Expression [5]
Group XIIB secretory phospholipase A2-like protein (PLA2G12B) OTY7GXA6 PG12B_HUMAN Decreases Expression [5]
Angiopoietin-related protein 4 (ANGPTL4) OTQL5SPX ANGL4_HUMAN Increases Expression [5]
Sulfiredoxin-1 (SRXN1) OTYDBO4L SRXN1_HUMAN Increases Expression [5]
Alanine--glyoxylate aminotransferase 2, mitochondrial (AGXT2) OTO6QUTM AGT2_HUMAN Decreases Expression [5]
Transmembrane 6 superfamily member 2 (TM6SF2) OTXMU5ZV TM6S2_HUMAN Decreases Expression [5]
DNA-directed RNA polymerase I subunit RPA49 (POLR1E) OTCBMKW6 RPA49_HUMAN Increases Expression [5]
Cytosolic beta-glucosidase (GBA3) OT86XWU2 GBA3_HUMAN Decreases Expression [5]
2-aminomuconic semialdehyde dehydrogenase (ALDH8A1) OTINY3MW AL8A1_HUMAN Decreases Expression [5]
Mid1-interacting protein 1 (MID1IP1) OTFCORJM M1IP1_HUMAN Decreases Expression [5]
NADPH oxidase 4 (NOX4) OTTYQ097 NOX4_HUMAN Decreases Expression [5]
PI-PLC X domain-containing protein 1 (PLCXD1) OTU7KCQL PLCX1_HUMAN Decreases Expression [5]
Ethanolamine kinase 2 (ETNK2) OT5S1Z75 EKI2_HUMAN Decreases Expression [5]
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 (SOHLH2) OTB9EM6C SOLH2_HUMAN Increases Expression [5]
H/ACA ribonucleoprotein complex subunit 1 (GAR1) OTA580RX GAR1_HUMAN Increases Expression [5]
Cingulin (CGN) OTBCQ8AQ CING_HUMAN Decreases Expression [5]
Alpha-aminoadipic semialdehyde synthase, mitochondrial (AASS) OTYCN07T AASS_HUMAN Decreases Expression [5]
Lipid transferase CIDEB (CIDEB) OT873IYM CIDEB_HUMAN Decreases Expression [5]
Annexin A10 (ANXA10) OTA8LWSL ANX10_HUMAN Decreases Expression [5]
Transcription factor SOX-13 (SOX13) OTCIF6KC SOX13_HUMAN Decreases Expression [5]
Microtubule-associated protein RP/EB family member 3 (MAPRE3) OTSCLETV MARE3_HUMAN Increases Expression [5]
Regulating synaptic membrane exocytosis protein 2 (RIMS2) OTQASWDH RIMS2_HUMAN Decreases Expression [5]
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C) OTEU05TX PPR3C_HUMAN Decreases Expression [5]
Endothelial lipase (LIPG) OTHEE942 LIPG_HUMAN Decreases Expression [5]
Adhesion G-protein coupled receptor G1 (ADGRG1) OTQBB8NT AGRG1_HUMAN Increases Expression [5]
Solute carrier family 22 member 7 (SLC22A7) OTKTNH1W S22A7_HUMAN Decreases Expression [5]
Agouti-related protein (AGRP) OT7XRHWU AGRP_HUMAN Increases Expression [6]
Golgi integral membrane protein 4 (GOLIM4) OTB5NV8A GOLI4_HUMAN Decreases Expression [6]
Long-chain fatty acid transport protein 2 (SLC27A2) OT7JEG5F S27A2_HUMAN Decreases Expression [6]
Rho guanine nucleotide exchange factor 10 (ARHGEF10) OTHJ1Y4I ARHGA_HUMAN Decreases Expression [6]
Secretory carrier-associated membrane protein 1 (SCAMP1) OTFS4IKJ SCAM1_HUMAN Increases Expression [6]
Protein phosphatase 1D (PPM1D) OT8NLZ9D PPM1D_HUMAN Increases Expression [6]
Cochlin (COCH) OTBEHD89 COCH_HUMAN Decreases Expression [6]
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) OT6CLFXB MCAT_HUMAN Decreases Expression [6]
NUAK family SNF1-like kinase 1 (NUAK1) OTLLHJJQ NUAK1_HUMAN Decreases Expression [6]
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (MAN1A2) OTITCN3Q MA1A2_HUMAN Decreases Expression [6]
E3 ubiquitin-protein ligase listerin (LTN1) OTIW2HTX LTN1_HUMAN Decreases Expression [6]
Solute carrier organic anion transporter family member 2B1 (SLCO2B1) OTERJ4VQ SO2B1_HUMAN Decreases Expression [6]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [6]
Tyrosine-protein kinase Fgr (FGR) OTCUYU9F FGR_HUMAN Increases Expression [6]
RNA-binding protein RO60 (RO60) OTLGM5A8 RO60_HUMAN Decreases Expression [6]
Fos-related antigen 1 (FOSL1) OT9YTYMB FOSL1_HUMAN Increases Expression [6]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [6]
Retinoic acid receptor RXR-alpha (RXRA) OTP1TBDM RXRA_HUMAN Decreases Expression [6]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [6]
ETS domain-containing protein Elk-4 (ELK4) OTVSSEOE ELK4_HUMAN Increases Expression [6]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [6]
Serine/threonine-protein kinase SIK1 (SIK1) OT6FCHME SIK1_HUMAN Increases Expression [6]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Decreases Expression [6]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Expression [6]
Adenylate cyclase type 1 (ADCY1) OTSLLFZO ADCY1_HUMAN Decreases Expression [6]
Zinc finger protein Rlf (RLF) OTCSPZVK RLF_HUMAN Increases Expression [6]
Kelch-like ECH-associated protein 1 (KEAP1) OTFHOD0C KEAP1_HUMAN Increases Expression [6]
Src substrate cortactin (CTTN) OTJRG4ES SRC8_HUMAN Decreases Expression [6]
Enhancer of filamentation 1 (NEDD9) OTGCFN4M CASL_HUMAN Decreases Expression [6]
Protein disulfide-isomerase A5 (PDIA5) OT76ZSX5 PDIA5_HUMAN Decreases Expression [6]
Neuronal regeneration-related protein (NREP) OT2AZPKK NREP_HUMAN Decreases Expression [6]
Dual specificity protein phosphatase 5 (DUSP5) OTH96RA7 DUS5_HUMAN Increases Expression [6]
Atos homolog protein A (ATOSA) OTWFM5G0 ATOSA_HUMAN Decreases Expression [6]
Glycerol-3-phosphate acyltransferase 3 (GPAT3) OTJUGPK0 GPAT3_HUMAN Increases Expression [6]
Ribosomal protein eS27-like (RPS27L) OTZWHU0N RS27L_HUMAN Decreases Expression [6]
Protein mono-ADP-ribosyltransferase TIPARP (TIPARP) OTZ4BG4B PARPT_HUMAN Increases Expression [6]
Extracellular sulfatase Sulf-2 (SULF2) OTIXMUVL SULF2_HUMAN Decreases Expression [6]
SH3 domain and tetratricopeptide repeat-containing protein 1 (SH3TC1) OT0HYZIU S3TC1_HUMAN Increases Expression [6]
Uncharacterized protein C4orf3 (C4ORF3) OT6TFN1O CD003_HUMAN Decreases Expression [6]
Sortilin-related receptor (SORL1) OTQ8FFNS SORL_HUMAN Decreases Expression [6]
GTP-binding protein Rit1 (RIT1) OTVNOGOH RIT1_HUMAN Increases Expression [6]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Decreases Expression [6]
Protein orai-3 (ORAI3) OTUP3OH3 ORAI3_HUMAN Decreases Expression [6]
Ectonucleoside triphosphate diphosphohydrolase 7 (ENTPD7) OT3QER33 ENTP7_HUMAN Decreases Expression [6]
Oxidative stress-induced growth inhibitor 1 (OSGIN1) OT9KIVZW OSGI1_HUMAN Increases Expression [6]
Insulin-induced gene 2 protein (INSIG2) OTX4VY51 INSI2_HUMAN Decreases Expression [6]
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2) OTM3CQZT BIG2_HUMAN Increases Expression [6]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Affects Localization [31]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [31]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Increases Expression [31]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Increases Expression [32]
Apoptotic protease-activating factor 1 (APAF1) OTJWIVY0 APAF_HUMAN Decreases Expression [33]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [34]
Neuropilin-1 (NRP1) OTCGULYV NRP1_HUMAN Decreases Expression [33]
Centrin-3 (CETN3) OTG4PL7H CETN3_HUMAN Decreases Expression [33]
Protein phosphatase 1G (PPM1G) OTLZL9CG PPM1G_HUMAN Increases Expression [33]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [10]
Transmembrane protease serine 2 (TMPRSS2) OTN44YQ5 TMPS2_HUMAN Increases Expression [35]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [10]
Death effector domain-containing protein (DEDD) OTIL349E DEDD_HUMAN Increases Expression [33]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [33]
STAM-binding protein (STAMBP) OTOT2OXM STABP_HUMAN Decreases Expression [33]
Centrosomal protein 43 (CEP43) OT8TRHCF CEP43_HUMAN Decreases Expression [33]
Cytochrome b5 (CYB5A) OT6SN4RM CYB5_HUMAN Affects Expression [7]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Increases Expression [36]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Increases Phosphorylation [37]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Affects Expression [7]
Carbonic anhydrase 1 (CA1) OTNFBVVQ CAH1_HUMAN Affects Expression [7]
Carbonic anhydrase 2 (CA2) OTJRMUAG CAH2_HUMAN Affects Expression [7]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [38]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Decreases Expression [39]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Expression [40]
Insulin (INS) OTZ85PDU INS_HUMAN Increases Expression [41]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Decreases Secretion [42]
Interferon gamma (IFNG) OTXG9JM7 IFNG_HUMAN Affects Expression [43]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Secretion [44]
Alpha-crystallin B chain (CRYAB) OTY4JGYU CRYAB_HUMAN Affects Expression [7]
Prelamin-A/C (LMNA) OT3SG7ZR LMNA_HUMAN Affects Expression [7]
Fibrinogen gamma chain (FGG) OT5BJSEX FIBG_HUMAN Affects Expression [7]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Decreases Expression [45]
Fibronectin (FN1) OTB5ZN4Q FINC_HUMAN Decreases Expression [46]
Serotransferrin (TF) OT41PEMS TRFE_HUMAN Affects Expression [7]
Ferritin light chain (FTL) OTYQA8A6 FRIL_HUMAN Affects Expression [7]
Annexin A1 (ANXA1) OT5OFDJC ANXA1_HUMAN Affects Expression [7]
Trefoil factor 1 (TFF1) OTCYQH4F TFF1_HUMAN Increases Expression [47]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Decreases Expression [48]
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) OTBPMIMW G3P_HUMAN Affects Expression [7]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Expression [33]
Heat shock protein beta-1 (HSPB1) OTHFZ8ED HSPB1_HUMAN Affects Expression [7]
Insulin-like growth factor I (IGF1) OTIIZR61 IGF1_HUMAN Decreases Secretion [49]
Integrin beta-3 (ITGB3) OTWCK1K6 ITB3_HUMAN Affects Expression [7]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Affects Expression [43]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Decreases Expression [50]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Expression [51]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Decreases Expression [52]
Transcription factor AP-2-alpha (TFAP2A) OTMYT3NK AP2A_HUMAN Increases Expression [53]
Beta-casein (CSN2) OT22C0PD CASB_HUMAN Increases Expression [54]
Insulin receptor (INSR) OTTY341H INSR_HUMAN Increases Phosphorylation [55]
Gelsolin (GSN) OT4KS2UU GELS_HUMAN Increases Expression [56]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Phosphorylation [57]
ATP synthase subunit beta, mitochondrial (ATP5F1B) OTLFZUQK ATPB_HUMAN Decreases Expression [58]
Alpha-enolase (ENO1) OTB1KWJS ENOA_HUMAN Affects Expression [7]
Tropomyosin alpha-3 chain (TPM3) OT5RU5G6 TPM3_HUMAN Decreases Expression [59]
Lipoprotein lipase (LPL) OTTW0267 LIPL_HUMAN Increases Expression [60]
Protein disulfide-isomerase (P4HB) OTTYNYPF PDIA1_HUMAN Affects Expression [7]
Annexin A2 (ANXA2) OTFNS0CC ANXA2_HUMAN Affects Expression [7]
Transcription factor Sp1 (SP1) OTISPT4X SP1_HUMAN Decreases Expression [46]
Integrin alpha-IIb (ITGA2B) OT4Y17PY ITA2B_HUMAN Affects Expression [7]
Integrin alpha-5 (ITGA5) OT3RCI67 ITA5_HUMAN Increases Expression [10]
Galectin-1 (LGALS1) OT8LDFWR LEG1_HUMAN Affects Expression [7]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Expression [61]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [62]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Increases Expression [63]
Hepatic triacylglycerol lipase (LIPC) OTZY5SC9 LIPC_HUMAN Increases Expression [39]
Lysosome-associated membrane glycoprotein 1 (LAMP1) OTYE92QY LAMP1_HUMAN Increases Expression [57]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Increases Expression [33]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Decreases Expression [64]
Collagen alpha-1(VI) chain (COL6A1) OTYKSCOB CO6A1_HUMAN Affects Expression [7]
Collagen alpha-2(VI) chain (COL6A2) OTQC6PPO CO6A2_HUMAN Affects Expression [7]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Increases Expression [56]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Decreases Response To Substance [65]
Beta-3 adrenergic receptor (ADRB3) OTPMG4V7 ADRB3_HUMAN Decreases Expression [66]
Hepatocyte growth factor (HGF) OTGHUA23 HGF_HUMAN Increases Expression [67]
Nidogen-1 (NID1) OTKLBLS6 NID1_HUMAN Affects Expression [7]
Endoplasmin (HSP90B1) OT02XLBR ENPL_HUMAN Affects Expression [7]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Decreases Expression [68]
Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4) OTJZG0LD GLUT4_HUMAN Increases Expression [69]
Insulin-degrading enzyme (IDE) OT5GQTJ5 IDE_HUMAN Increases Expression [70]
Fatty acid-binding protein, adipocyte (FABP4) OT3DKFOU FABP4_HUMAN Increases Expression [71]
P-selectin (SELP) OTWR90PK LYAM3_HUMAN Decreases Expression [72]
Cyclic AMP-responsive element-binding protein 1 (CREB1) OT1MDLA1 CREB1_HUMAN Decreases Phosphorylation [46]
Platelet endothelial cell adhesion molecule (PECAM1) OTXOM4D9 PECA1_HUMAN Decreases Expression [73]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (GNB3) OTA6HYBA GBB3_HUMAN Affects Expression [7]
E-selectin (SELE) OT33RZWY LYAM2_HUMAN Decreases Expression [45]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) OTPGAU0U AT2A2_HUMAN Increases Expression [74]
Platelet glycoprotein 4 (CD36) OT5CZWKY CD36_HUMAN Increases Expression [75]
Neutrophil cytosol factor 2 (NCF2) OTAUW7L2 NCF2_HUMAN Decreases Expression [76]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [68]
Filamin-A (FLNA) OTYZ9JXM FLNA_HUMAN Affects Expression [7]
Thromboxane A2 receptor (TBXA2R) OT9CIHQ5 TA2R_HUMAN Decreases Expression [77]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Increases Expression [78]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Decreases Phosphorylation [79]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [56]
Endothelin receptor type B (EDNRB) OTLLZV3P EDNRB_HUMAN Increases Expression [80]
Cyclin-C (CCNC) OTMVK4K4 CCNC_HUMAN Decreases Expression [33]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Decreases Expression [68]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Expression [68]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [56]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Decreases Phosphorylation [61]
Moesin (MSN) OTZJ4J6G MOES_HUMAN Affects Expression [7]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Increases Phosphorylation [81]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) OT5BZ1J9 P85A_HUMAN Increases Expression [9]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Phosphorylation [81]
Retinoic acid receptor RXR-beta (RXRB) OTNPDXG2 RXRB_HUMAN Affects Binding [82]
Nitric oxide synthase 3 (NOS3) OTLDT7NR NOS3_HUMAN Increases Phosphorylation [83]
Protein disulfide-isomerase A3 (PDIA3) OTHPQ0Q3 PDIA3_HUMAN Affects Expression [7]
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) OTYA3GB4 2AAA_HUMAN Increases Expression [33]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Decreases Expression [64]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Decreases Expression [68]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Phosphorylation [84]
Peroxiredoxin-2 (PRDX2) OTLWCY9T PRDX2_HUMAN Affects Expression [7]
C-C chemokine receptor type 7 (CCR7) OTHFUOYE CCR7_HUMAN Decreases Expression [85]
T-lymphocyte activation antigen CD80 (CD80) OTJBLUQE CD80_HUMAN Decreases Expression [85]
Polycomb complex protein BMI-1 (BMI1) OTROVLJ0 BMI1_HUMAN Decreases Expression [73]
Nitric oxide synthase, inducible (NOS2) OTKKIOJ1 NOS2_HUMAN Decreases Expression [44]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Decreases Expression [86]
Phosphoenolpyruvate carboxykinase, cytosolic (PCK1) OTNWEJ5Y PCKGC_HUMAN Increases Expression [87]
Insulin receptor substrate 1 (IRS1) OTNO82CU IRS1_HUMAN Increases Phosphorylation [55]
Myosin-9 (MYH9) OT94Z706 MYH9_HUMAN Affects Expression [7]
Tumor necrosis factor receptor superfamily member 3 (LTBR) OT2HVZGV TNR3_HUMAN Increases Expression [33]
Sterol regulatory element-binding protein 1 (SREBF1) OTWBRPAI SRBP1_HUMAN Increases Expression [54]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Decreases Expression [44]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [33]
Leptin (LEP) OT5Q7ODW LEP_HUMAN Decreases Expression [9]
Neuroblastoma suppressor of tumorigenicity 1 (NBL1) OTT37U4O NBL1_HUMAN Increases Expression [33]
T-lymphocyte activation antigen CD86 (CD86) OTJCSBPC CD86_HUMAN Increases Expression [85]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Decreases Expression [33]
Nicotinamide phosphoribosyltransferase (NAMPT) OTVJR3GL NAMPT_HUMAN Affects Expression [88]
Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4) OT1H0ZXC ACHA4_HUMAN Decreases Expression [81]
ATP-binding cassette sub-family G member 1 (ABCG1) OT5BG6MK ABCG1_HUMAN Increases Expression [89]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [73]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [64]
Stromal cell-derived factor 1 (CXCL12) OT2QX5LL SDF1_HUMAN Decreases Response To Substance [65]
Retinoic acid receptor RXR-gamma (RXRG) OT254B09 RXRG_HUMAN Affects Binding [82]
CX3C chemokine receptor 1 (CX3CR1) OTIM9XT8 CX3C1_HUMAN Decreases Expression [90]
Fatty acid synthase (FASN) OTFII9KG FAS_HUMAN Increases Expression [54]
Caspase-4 (CASP4) OTVQTV1L CASP4_HUMAN Decreases Expression [33]
Steroidogenic acute regulatory protein, mitochondrial (STAR) OTFEZ5AI STAR_HUMAN Increases Expression [42]
CCAAT/enhancer-binding protein alpha (CEBPA) OTOM9OE4 CEBPA_HUMAN Increases Expression [91]
Acyl-coenzyme A thioesterase 2, mitochondrial (ACOT2) OTAKUO27 ACOT2_HUMAN Increases Expression [36]
Tuberin (TSC2) OT47LWI9 TSC2_HUMAN Increases Phosphorylation [79]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Increases Phosphorylation [92]
Cyclin-dependent kinase 7 (CDK7) OTAO19PQ CDK7_HUMAN Decreases Expression [33]
Death-associated protein 1 (DAP) OT5YLL7E DAP1_HUMAN Increases Expression [33]
Small ribosomal subunit protein mS29 (DAP3) OTNPEZYM RT29_HUMAN Decreases Expression [33]
Caveolin-2 (CAV2) OT1FGRQX CAV2_HUMAN Increases Expression [54]
Hexokinase-2 (HK2) OTC0GCQO HXK2_HUMAN Increases Expression [93]
Microsomal triglyceride transfer protein large subunit (MTTP) OTNUVSDT MTP_HUMAN Increases Expression [36]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [94]
Laminin subunit beta-2 (LAMB2) OT71OI2Y LAMB2_HUMAN Affects Expression [7]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Increases Expression [95]
GTP-binding nuclear protein Ran (RAN) OT2TER5M RAN_HUMAN Decreases Expression [33]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (GNB1) OTLL7L74 GBB1_HUMAN Affects Expression [7]
Tropomyosin alpha-4 chain (TPM4) OTN4YLYR TPM4_HUMAN Affects Expression [7]
Fractalkine (CX3CL1) OTPLGI0E X3CL1_HUMAN Affects Localization [90]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) OTHF4H9U DHI2_HUMAN Increases Activity [96]
Protein delta homolog 1 (DLK1) OTE1VLNB DLK1_HUMAN Decreases Expression [97]
Fatty acid-binding protein 5 (FABP5) OTNM186C FABP5_HUMAN Affects Expression [7]
Caveolin-1 (CAV1) OTEZUR1L CAV1_HUMAN Increases Expression [98]
Peroxisome proliferator-activated receptor delta (PPARD) OTI4WTOP PPARD_HUMAN Increases Expression [99]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Decreases Phosphorylation [100]
Hormone-sensitive lipase (LIPE) OTMMVJ8A LIPS_HUMAN Increases Expression [39]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [33]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Increases Expression [33]
Peroxisome proliferator-activated receptor alpha (PPARA) OTK095PP PPARA_HUMAN Affects Binding [101]
Prolow-density lipoprotein receptor-related protein 1 (LRP1) OTHTEH4G LRP1_HUMAN Increases Expression [102]
Peroxisomal bifunctional enzyme (EHHADH) OTBAAHL5 ECHP_HUMAN Increases Expression [36]
Oxysterols receptor LXR-alpha (NR1H3) OT54YZ9I NR1H3_HUMAN Increases Expression [98]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Increases Expression [103]
Runt-related transcription factor 2 (RUNX2) OT97RQQM RUNX2_HUMAN Decreases Expression [104]
Interleukin-18 (IL18) OTBB2A8O IL18_HUMAN Decreases Expression [51]
Beclin-1 (BECN1) OT4X293M BECN1_HUMAN Increases Expression [57]
LIM and SH3 domain protein 1 (LASP1) OT2QIDCL LASP1_HUMAN Affects Expression [7]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Increases Expression [36]
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) OTM0A0DY ACOX1_HUMAN Increases Expression [39]
Mediator of RNA polymerase II transcription subunit 1 (MED1) OTOO24C4 MED1_HUMAN Affects Binding [105]
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Increases Expression [106]
Transcription factor E2F4 (E2F4) OTB3JFH4 E2F4_HUMAN Decreases Expression [107]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Expression [33]
kinase isozyme 4, mitochondrial (PDK4) OTCMHMBZ PDK4_HUMAN Increases Expression [93]
Caveolae-associated protein 1 (CAVIN1) OTFO915U CAVN1_HUMAN Affects Expression [7]
Long-chain fatty acid transport protein 1 (SLC27A1) OTK03OZN S27A1_HUMAN Decreases Expression [93]
Adiponectin receptor protein 2 (ADIPOR2) OT2HDTL8 PAQR2_HUMAN Increases Expression [108]
Ferritin, mitochondrial (FTMT) OTIUX6XG FTMT_HUMAN Affects Expression [7]
Carnitine O-palmitoyltransferase 1, muscle isoform (CPT1B) OTDNRW37 CPT1B_HUMAN Increases Expression [109]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Increases Expression [33]
Adiponectin receptor protein 1 (ADIPOR1) OT65ZFZN PAQR1_HUMAN Affects Expression [110]
Necdin (NDN) OTYBYJ82 NECD_HUMAN Increases Expression [107]
Retinoic acid receptor responder protein 2 (RARRES2) OT1BJE8K RARR2_HUMAN Decreases Expression [111]
Serine/threonine-protein kinase PINK1, mitochondrial (PINK1) OT50NR57 PINK1_HUMAN Increases Expression [112]
Angiotensin-converting enzyme 2 (ACE2) OTTRZGU7 ACE2_HUMAN Decreases Expression [35]
COMM domain-containing protein 5 (COMMD5) OT6R7DXN COMD5_HUMAN Increases Expression [113]
Ras-related protein Rab-1B (RAB1B) OTAFCUAS RAB1B_HUMAN Increases Expression [33]
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) OTR1XD9B GPAT1_HUMAN Increases Expression [36]
Chorion-specific transcription factor GCMa (GCM1) OT5CPAUT GCM1_HUMAN Increases Expression [15]
Fibroblast growth factor 21 (FGF21) OT3RXVRD FGF21_HUMAN Increases Expression [114]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) OTHCDQ22 PRGC1_HUMAN Increases Expression [69]
Probable ATP-dependent RNA helicase DDX41 (DDX41) OT6KEIHP DDX41_HUMAN Increases Expression [33]
Cyclin-L1 (CCNL1) OTAJSS3D CCNL1_HUMAN Decreases Expression [33]
Anaphase-promoting complex subunit 10 (ANAPC10) OTM03SME APC10_HUMAN Decreases Expression [33]
Insulin receptor substrate 2 (IRS2) OT46MJBE IRS2_HUMAN Increases Expression [115]
Cytochrome P450 2C8 (CYP2C8) OTHCWT42 CP2C8_HUMAN Decreases Metabolism [116]
Nuclear factor of activated T-cells, cytoplasmic 2 (NFATC2) OTK5T6HZ NFAC2_HUMAN Affects Response To Substance [117]
Phosphatidate phosphatase LPIN1 (LPIN1) OTQ75KF2 LPIN1_HUMAN Increases Response To Substance [118]
------------------------------------------------------------------------------------
⏷ Show the Full List of 589 DOT(s)
Indication(s) of Cabozantinib
Disease Entry ICD 11 Status REF
Medullary thyroid gland carcinoma N.A. Approved [2]
Thyroid cancer 2D10 Approved [3]
Ovarian cancer 2C73 Phase 2 [3]
Cabozantinib Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Proto-oncogene c-Met (MET) TTNDSF4 MET_HUMAN Inhibitor [119]
Vascular endothelial growth factor receptor 2 (KDR) TTUTJGQ VGFR2_HUMAN Inhibitor [119]
------------------------------------------------------------------------------------
Cabozantinib Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [120]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [121]
------------------------------------------------------------------------------------
Cabozantinib Interacts with 2 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Decreases Phosphorylation [122]
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Increases Secretion [123]
------------------------------------------------------------------------------------

References

1 ClinicalTrials.gov (NCT01100619) A Drug-Drug Interaction Study of the Effects of XL184 (Cabozantinib) on Rosiglitazone in Subjects With Solid Tumors
2 Cabozantinib FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5887).
4 PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62.
5 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
6 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
7 Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake. Obesity (Silver Spring). 2010 Jan;18(1):27-34. doi: 10.1038/oby.2009.208. Epub 2009 Jun 25.
8 Rosiglitazone induces the unfolded protein response, but has no significant effect on cell viability, in monocytic and vascular smooth muscle cells. Biochem Biophys Res Commun. 2010 Oct 1;400(4):689-95. doi: 10.1016/j.bbrc.2010.08.129. Epub 2010 Sep 9.
9 Regulation of gene expression by activation of the peroxisome proliferator-activated receptor gamma with rosiglitazone (BRL 49653) in human adipocytes. Biochem Biophys Res Commun. 1999 Nov;265(1):265-71. doi: 10.1006/bbrc.1999.1657.
10 All-trans retinoic acid can intensify the growth inhibition and differentiation induction effect of rosiglitazone on multiple myeloma cells. Eur J Haematol. 2009 Sep;83(3):191-202. doi: 10.1111/j.1600-0609.2009.01277.x. Epub 2009 May 8.
11 ATP-binding cassette transporters in human heart failure. Naunyn Schmiedebergs Arch Pharmacol. 2008 May;377(3):231-43.
12 Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics of pioglitazone. Clin Pharmacol Ther. 2005 May;77(5):404-14.
13 Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone. Br J Clin Pharmacol. 1999 Sep;48(3):424-32.
14 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
15 Regulation of the placental BCRP transporter by PPAR gamma. J Biochem Mol Toxicol. 2017 May;31(5):10.1002/jbt.21880. doi: 10.1002/jbt.21880. Epub 2016 Nov 23.
16 Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition. Drug Metab Dispos. 2003 Apr;31(4):439-46.
17 Cinnamic acid based thiazolidinediones inhibit human P450c17 and 3beta-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPARgamma agonist activity. J Mol Endocrinol. 2004 Apr;32(2):425-36.
18 The PPARgamma ligands PGJ2 and rosiglitazone show a differential ability to inhibit proliferation and to induce apoptosis and differentiation of human glioblastoma cell lines. Int J Oncol. 2004 Aug;25(2):493-502.
19 Comparison of the effects of pioglitazone and rosiglitazone on macrophage foam cell formation. Biochem Biophys Res Commun. 2004 Oct 22;323(3):782-8.
20 Trialkyltin compounds bind retinoid X receptor to alter human placental endocrine functions. Mol Endocrinol. 2005 Oct;19(10):2502-16.
21 Effects of rosiglitazone and atorvastatin on the expression of genes that control cholesterol homeostasis in differentiating monocytes. Biochem Pharmacol. 2006 Feb 28;71(5):605-14.
22 Effects of chronic rosiglitazone therapy on gene expression in human adipose tissue in vivo in patients with type 2 diabetes. J Clin Endocrinol Metab. 2007 Feb;92(2):720-4.
23 Apoptotic action of peroxisome proliferator-activated receptor-gamma activation in human non small-cell lung cancer is mediated via proline oxidase-induced reactive oxygen species formation. Mol Pharmacol. 2007 Sep;72(3):674-85.
24 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
25 Effects of PPAR-gamma agonist rosiglitazone on MMP-9 and TIMP-1 expression of monocyte-derived macrophages isolated from patients with acute coronary syndrome. Zhonghua Xin Xue Guan Bing Za Zhi. 2009 Aug;37(8):739-45.
26 Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicol Sci. 2010 Dec; 118(2):485-500.
27 Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs. ACS Med Chem Lett. 2011 Oct 15;3(1):39-42.
28 Activity, inhibition, and induction of cytochrome P450 2J2 in adult human primary cardiomyocytes. Drug Metab Dispos. 2013 Dec;41(12):2087-94.
29 PPARgama activation rescues mitochondrial function from inhibition of complex I and loss of PINK1. Exp Neurol. 2014 Mar;253:16-27.
30 Rosiglitazone inhibits chlorpyrifos-induced apoptosis via modulation of the oxidative stress and inflammatory response in SH-SY5Y cells. Toxicol Appl Pharmacol. 2014 Jul 15;278(2):159-71.
31 A comprehensive evaluation of anti-diabetic drugs on nuclear receptor PXR platform. Toxicol In Vitro. 2019 Oct;60:347-358.
32 Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma. Diabetes. 2005 May;54(5):1379-84. doi: 10.2337/diabetes.54.5.1379.
33 Rosiglitazone sensitizes MDA-MB-231 breast cancer cells to anti-tumour effects of tumour necrosis factor-alpha, CH11 and CYC202. Endocr Relat Cancer. 2007 Jun;14(2):305-15. doi: 10.1677/ERC-06-0003.
34 Rosiglitazone promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP. Free Radic Biol Med. 2008 Mar 15;44(6):1055-68. doi: 10.1016/j.freeradbiomed.2007.12.001. Epub 2007 Dec 8.
35 Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Arch Toxicol. 2020 Dec;94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. Epub 2020 Aug 17.
36 Replacement per- and polyfluoroalkyl substances (PFAS) are potent modulators of lipogenic and drug metabolizing gene expression signatures in primary human hepatocytes. Toxicol Appl Pharmacol. 2022 May 1;442:115991. doi: 10.1016/j.taap.2022.115991. Epub 2022 Mar 23.
37 Rosiglitazone induces caveolin-1 by PPARgamma-dependent and PPRE-independent mechanisms: the role of EGF receptor signaling and its effect on cancer cell drug resistance. Anticancer Res. 2008 Mar-Apr;28(2A):895-906.
38 [Proliferation and apoptosis effect of rosiglitazone on human ovarian cancer cell line SKOV3]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2009 Mar;40(2):217-22.
39 In Vitro and In Vivo Characterizations of Chiglitazar, a Newly Identified PPAR Pan-Agonist. PPAR Res. 2012;2012:546548. doi: 10.1155/2012/546548. Epub 2012 Oct 22.
40 [Effect of Rosiglitazone on the proliferation and the production of transforming growth factor-beta 1 in cultured human Tenon' s capsule fibroblasts]. Zhonghua Yan Ke Za Zhi. 2008 May;44(5):413-7.
41 PPARgamma-dependent and -independent effects of rosiglitazone on lipotoxic human pancreatic islets. Biochem Biophys Res Commun. 2008 Feb 22;366(4):1096-101. doi: 10.1016/j.bbrc.2007.12.088. Epub 2007 Dec 26.
42 Direct rosiglitazone action on steroidogenesis and proinflammatory factor production in human granulosa-lutein cells. Reprod Biol Endocrinol. 2009 Dec 9;7:147. doi: 10.1186/1477-7827-7-147.
43 [Effect of rosiglitazone on the expression of T-bet/GATA-3 in T lymphocytes in patients with acute asthma]. Zhonghua Jie He He Hu Xi Za Zhi. 2007 Feb;30(2):116-20.
44 The PPAR-dependent effect of flavonoid luteolin against damage induced by the chemotherapeutic irinotecan in human intestinal cells. Chem Biol Interact. 2022 Jan 5;351:109712. doi: 10.1016/j.cbi.2021.109712. Epub 2021 Oct 23.
45 Rapid effects of rosiglitazone treatment on endothelial function and inflammatory biomarkers. Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1804-9. doi: 10.1161/01.ATV.0000176192.16951.9a. Epub 2005 Jul 7.
46 Peroxisome proliferator-activated receptor-gamma ligands suppress fibronectin gene expression in human lung carcinoma cells: involvement of both CRE and Sp1. Am J Physiol Lung Cell Mol Physiol. 2005 Sep;289(3):L419-28. doi: 10.1152/ajplung.00002.2005. Epub 2005 May 20.
47 Transactivation of ERalpha by Rosiglitazone induces proliferation in breast cancer cells. Breast Cancer Res Treat. 2008 Mar;108(1):23-33. doi: 10.1007/s10549-007-9575-y. Epub 2007 Apr 24.
48 Manganese superoxide dismutase is a promising target for enhancing chemosensitivity of basal-like breast carcinoma. Antioxid Redox Signal. 2014 May 20;20(15):2326-46. doi: 10.1089/ars.2013.5295. Epub 2013 Nov 14.
49 Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by rosiglitazone suppresses components of the insulin-like growth factor regulatory system in vitro and in vivo. Endocrinology. 2007 Feb;148(2):903-11. doi: 10.1210/en.2006-1121. Epub 2006 Nov 22.
50 Effects of fibrate compounds on expression of plasminogen activator inhibitor-1 by cultured endothelial cells. Arterioscler Thromb Vasc Biol. 1999 Jun;19(6):1577-81. doi: 10.1161/01.atv.19.6.1577.
51 Effect of rosiglitazone on endothelial function and inflammatory markers in patients with the metabolic syndrome. Diabetes Care. 2006 May;29(5):1071-6. doi: 10.2337/diacare.2951071.
52 PPARgamma inhibits NF-kappaB-dependent transcriptional activation in skeletal muscle. Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E174-83. doi: 10.1152/ajpendo.90632.2008. Epub 2009 May 5.
53 VCE-004.8, A Multitarget Cannabinoquinone, Attenuates Adipogenesis and Prevents Diet-Induced Obesity. Sci Rep. 2018 Oct 31;8(1):16092. doi: 10.1038/s41598-018-34259-0.
54 Differential anti-proliferative actions of peroxisome proliferator-activated receptor-gamma agonists in MCF-7 breast cancer cells. Biochem Pharmacol. 2006 Aug 28;72(5):530-40. doi: 10.1016/j.bcp.2006.05.009. Epub 2006 Jun 27.
55 Methamphetamine exposure upregulates the amyloid precursor protein and hyperphosphorylated tau expression: The roles of insulin signaling in SH-SY5Y cell line. J Toxicol Sci. 2019;44(7):493-503. doi: 10.2131/jts.44.493.
56 Regulatory role of KEAP1 and NRF2 in PPAR expression and chemoresistance in human non-small-cell lung carcinoma cells. Free Radic Biol Med. 2012 Aug 15;53(4):758-68. doi: 10.1016/j.freeradbiomed.2012.05.041. Epub 2012 Jun 7.
57 Rosiglitazone induces autophagy in H295R and cell cycle deregulation in SW13 adrenocortical cancer cells. Exp Cell Res. 2011 Jun 10;317(10):1397-410. doi: 10.1016/j.yexcr.2011.02.014. Epub 2011 Mar 3.
58 Troglitazone induces cytotoxicity in part by promoting the degradation of peroxisome proliferator-activated receptor co-activator-1 protein. Br J Pharmacol. 2010 Oct;161(4):771-81. doi: 10.1111/j.1476-5381.2010.00900.x.
59 Mesalamine suppresses the expression of TC22, a novel tropomyosin isoform associated with colonic neoplasia. Mol Pharmacol. 2009 Jul;76(1):183-91. doi: 10.1124/mol.109.056028. Epub 2009 Apr 15.
60 Effects of rosiglitazone and linoleic acid on human preadipocyte differentiation. Eur J Clin Invest. 2003 Jul;33(7):574-81. doi: 10.1046/j.1365-2362.2003.01178.x.
61 Activation of peroxisome proliferator-activated receptor gamma suppresses nuclear factor kappa B-mediated apoptosis induced by Helicobacter pylori in gastric epithelial cells. J Biol Chem. 2001 Aug 17;276(33):31059-66. doi: 10.1074/jbc.M104141200. Epub 2001 Jun 7.
62 Inhibition of COX-2 and activation of peroxisome proliferator-activated receptor gamma synergistically inhibits proliferation and induces apoptosis of human pancreatic carcinoma cells. Cancer Lett. 2009 Mar 18;275(2):247-55. doi: 10.1016/j.canlet.2008.10.023. Epub 2008 Dec 3.
63 Chaperone proteins involved in troglitazone-induced toxicity in human hepatoma cell lines. Toxicol Sci. 2005 Feb;83(2):293-302. doi: 10.1093/toxsci/kfi022. Epub 2004 Nov 3.
64 Rosiglitazone inhibits cell proliferation by inducing G1 cell cycle arrest and apoptosis in ADPKD cyst-lining epithelia cells. Basic Clin Pharmacol Toxicol. 2010 Jun;106(6):523-30. doi: 10.1111/j.1742-7843.2010.00539.x. Epub 2010 Feb 22.
65 Telmisartan inhibits CD4-positive lymphocyte migration independent of the angiotensin type 1 receptor via peroxisome proliferator-activated receptor-gamma. Hypertension. 2008 Feb;51(2):259-66. doi: 10.1161/HYPERTENSIONAHA.107.099028. Epub 2007 Dec 24.
66 Impact of rosiglitazone on the expression of beta3-AR in the stable cell lines expressed beta3-AR gene. Clin Chem Lab Med. 2007;45(11):1511-6. doi: 10.1515/CCLM.2007.315.
67 Orally administered berberine ameliorates bleomycin-induced pulmonary fibrosis in mice through promoting activation of PPAR- and subsequent expression of HGF in colons. Toxicol Appl Pharmacol. 2018 Mar 15;343:1-15. doi: 10.1016/j.taap.2018.02.001. Epub 2018 Feb 3.
68 Thiazolidinediones inhibit proliferation of microvascular and macrovascular cells by a PPARgamma-independent mechanism. Diabetologia. 2005 Mar;48(3):586-94. doi: 10.1007/s00125-005-1672-z. Epub 2005 Feb 24.
69 Enhanced insulin-stimulated glycogen synthesis in response to insulin, metformin or rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co-activator 1. Diabetologia. 2005 Jun;48(6):1173-9. doi: 10.1007/s00125-005-1741-3. Epub 2005 Apr 30.
70 Rosiglitazone protects neuroblastoma cells against advanced glycation end products-induced injury. Acta Pharmacol Sin. 2011 Aug;32(8):991-8. doi: 10.1038/aps.2011.81. Epub 2011 Jul 18.
71 Human adipocyte fatty acid-binding protein (aP2) gene promoter-driven reporter assay discriminates nonlipogenic peroxisome proliferator-activated receptor gamma ligands. J Pharmacol Exp Ther. 2004 Nov;311(2):467-75. doi: 10.1124/jpet.104.068254. Epub 2004 Jul 23.
72 Reduced plaque formation induced by rosiglitazone in an STZ-diabetes mouse model of atherosclerosis is associated with downregulation of adhesion molecules. Atherosclerosis. 2008 Jul;199(1):55-64. doi: 10.1016/j.atherosclerosis.2007.10.038. Epub 2008 Feb 21.
73 Rosiglitazone impairs proliferation of human adrenocortical cancer: preclinical study in a xenograft mouse model. Endocr Relat Cancer. 2010 Feb 18;17(1):169-77. doi: 10.1677/ERC-09-0170. Print 2010 Mar.
74 Rosiglitazone transiently disturbs calcium homeostasis in monocytic cells. Biochem Biophys Res Commun. 2008 Feb 1;366(1):149-55. doi: 10.1016/j.bbrc.2007.11.095. Epub 2007 Nov 29.
75 Reduction of intracellular cholesterol accumulation in THP-1 macrophages by a combination of rosiglitazone and atorvastatin. Biochem Pharmacol. 2004 Jul 1;68(1):155-63. doi: 10.1016/j.bcp.2004.03.009.
76 Activation of peroxisome proliferator-activated receptor gamma contributes to the survival of T lymphoma cells by affecting cellular metabolism. Am J Pathol. 2007 Feb;170(2):722-32. doi: 10.2353/ajpath.2007.060651.
77 Synthetic peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone suppress transcription by promoter 3 of the human thromboxane A2 receptor gene in human erythroleukemia cells. Biochem Pharmacol. 2006 Apr 28;71(9):1308-23. doi: 10.1016/j.bcp.2006.01.011. Epub 2006 Feb 23.
78 Interleukin-10 is upregulated by nanomolar rosiglitazone treatment of mature dendritic cells and human CD4+ T cells. Cytokine. 2007 Sep;39(3):184-91. doi: 10.1016/j.cyto.2007.07.191. Epub 2007 Sep 5.
79 Rosiglitazone, an Agonist of PPARgamma, Inhibits Non-Small Cell Carcinoma Cell Proliferation In Part through Activation of Tumor Sclerosis Complex-2. PPAR Res. 2007;2007:29632. doi: 10.1155/2007/29632.
80 Rosiglitazone attenuates endothelin-1-induced vasoconstriction by upregulating endothelial expression of endothelin B receptor. Hypertension. 2010 Jul;56(1):129-35. doi: 10.1161/HYPERTENSIONAHA.110.150375. Epub 2010 Jun 1.
81 Rosiglitazone inhibits alpha4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor gamma-independent signals. Mol Cancer Ther. 2009 Jan;8(1):110-8. doi: 10.1158/1535-7163.MCT-08-0719.
82 Phthalates efficiently bind to human peroxisome proliferator activated receptor and retinoid X receptor , , subtypes: an in silico approach. J Appl Toxicol. 2014 Jul;34(7):754-65. doi: 10.1002/jat.2902. Epub 2013 Jul 11.
83 Antiangiogenic effect of rosiglitazone is mediated via peroxisome proliferator-activated receptor gamma-activated maxi-K channel opening in human umbilical vein endothelial cells. J Biol Chem. 2006 May 12;281(19):13503-13512. doi: 10.1074/jbc.M510357200. Epub 2006 Mar 9.
84 Increased PTEN expression due to transcriptional activation of PPARgamma by Lovastatin and Rosiglitazone. Int J Cancer. 2006 May 15;118(10):2390-8. doi: 10.1002/ijc.21799.
85 9-cis-Retinoic acid (9cRA), a retinoid X receptor (RXR) ligand, exerts immunosuppressive effects on dendritic cells by RXR-dependent activation: inhibition of peroxisome proliferator-activated receptor gamma blocks some of the 9cRA activities, and precludes them to mature phenotype development. J Immunol. 2007 May 15;178(10):6130-9. doi: 10.4049/jimmunol.178.10.6130.
86 [Effects of rosiglitazone on the Hep-2 cell proliferation, cell cycle and COX-2 expression]. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 Apr;24(7):315-7.
87 Expression of phosphoenolpyruvate carboxykinase gene in human adipose tissue: induction by rosiglitazone and genetic analyses of the adipocyte-specific region of the promoter in type 2 diabetes. Biochimie. 2003 Dec;85(12):1257-64. doi: 10.1016/j.biochi.2003.10.016.
88 Visfatin is expressed in human granulosa cells: regulation by metformin through AMPK/SIRT1 pathways and its role in steroidogenesis. Mol Hum Reprod. 2013 May;19(5):313-26. doi: 10.1093/molehr/gat002. Epub 2013 Jan 11.
89 2,2',4,4'-Tetrabromodiphenyl Ether (PBDE 47) Selectively Stimulates Proatherogenic PPAR Signatures in Human THP-1 Macrophages to Contribute to Foam Cell Formation. Chem Res Toxicol. 2022 Jun 20;35(6):1023-1035. doi: 10.1021/acs.chemrestox.2c00043. Epub 2022 May 16.
90 Rosiglitazone activation of PPARgamma suppresses fractalkine signaling. J Mol Endocrinol. 2010 Feb;44(2):135-42. doi: 10.1677/JME-09-0090. Epub 2009 Oct 22.
91 Effects of Perinatal Exposure to Dibutyltin Chloride on Fat and Glucose Metabolism in Mice, and Molecular Mechanisms, in Vitro. Environ Health Perspect. 2018 May 21;126(5):057006. doi: 10.1289/EHP3030. eCollection 2018 May.
92 Fumosorinone, a novel PTP1B inhibitor, activates insulin signaling in insulin-resistance HepG2 cells and shows anti-diabetic effect in diabetic KKAy mice. Toxicol Appl Pharmacol. 2015 May 15;285(1):61-70. doi: 10.1016/j.taap.2015.03.011. Epub 2015 Mar 18.
93 The effects of rosiglitazone on fatty acid and triglyceride metabolism in type 2 diabetes. Diabetologia. 2005 Jan;48(1):83-95. doi: 10.1007/s00125-004-1619-9. Epub 2004 Dec 24.
94 Upregulation of PTEN involved in rosiglitazone-induced apoptosis in human hepatocellular carcinoma cells. Acta Pharmacol Sin. 2007 Jun;28(6):879-87. doi: 10.1111/j.1745-7254.2007.00571.x.
95 PPAR gamma-dependent anti-inflammatory action of rosiglitazone in human monocytes: suppression of TNF alpha secretion is not mediated by PTEN regulation. Biochem Biophys Res Commun. 2003 Apr 11;303(3):782-7. doi: 10.1016/s0006-291x(03)00418-2.
96 Tributyltin and triphenyltin induce 11-hydroxysteroid dehydrogenase 2 expression and activity through activation of retinoid X receptor . Toxicol Lett. 2020 Apr 1;322:39-49. doi: 10.1016/j.toxlet.2020.01.001. Epub 2020 Jan 9.
97 Bisphenol A diglycidyl ether induces adipogenic differentiation of multipotent stromal stem cells through a peroxisome proliferator-activated receptor gamma-independent mechanism. Environ Health Perspect. 2012 Jul;120(7):984-9. doi: 10.1289/ehp.1205063. Epub 2012 May 25.
98 Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism. J Lipid Res. 2004 Nov;45(11):2015-24. doi: 10.1194/jlr.M400049-JLR200. Epub 2004 Aug 16.
99 Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1 alpha and PPAR beta/delta gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus. Int J Obes (Lond). 2007 Aug;31(8):1302-10. doi: 10.1038/sj.ijo.0803567. Epub 2007 Feb 20.
100 PPARgamma activator rosiglitazone inhibits cell migration via upregulation of PTEN in human hepatocarcinoma cell line BEL-7404. Cancer Biol Ther. 2006 Aug;5(8):1008-14. doi: 10.4161/cbt.5.8.2887. Epub 2006 Aug 7.
101 Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB. Biochem Biophys Res Commun. 2002 Jan 11;290(1):131-9. doi: 10.1006/bbrc.2001.6141.
102 The effect of rosiglitazone on LRP1 expression and amyloid uptake in human brain microvascular endothelial cells: a possible role of a low-dose thiazolidinedione for dementia treatment. Int J Neuropsychopharmacol. 2012 Feb;15(1):135-42. doi: 10.1017/S1461145711001611. Epub 2011 Nov 1.
103 Involvement of peroxisome proliferator-activated receptor gamma (PPAR) and autophagic pathways in the mechanism of action of the tris(2,3-dibromopropyl) isocyanurate (TDBP-TAZTO or TBC) flame retardant in the lung adenocarcinoma (A549) cells in vitro. J Appl Toxicol. 2023 Sep;43(9):1358-1367. doi: 10.1002/jat.4470. Epub 2023 Mar 31.
104 Rosiglitazone stimulates adipogenesis and decreases osteoblastogenesis in human mesenchymal stem cells. J Endocrinol Invest. 2007 Oct;30(9):RC26-30. doi: 10.1007/BF03350807.
105 Selective Tissue Distribution Mediates Tissue-Dependent PPAR Activation and Insulin Sensitization by INT131, a Selective PPAR Modulator. Front Pharmacol. 2017 May 30;8:317. doi: 10.3389/fphar.2017.00317. eCollection 2017.
106 Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes. Diabetes. 2004 Aug;53(8):2169-76. doi: 10.2337/diabetes.53.8.2169.
107 Necdin and E2F4 are modulated by rosiglitazone therapy in diabetic human adipose and muscle tissue. Diabetes. 2006 Mar;55(3):640-50. doi: 10.2337/diabetes.55.03.06.db05-1015.
108 Regulation of adiponectin receptors in hepatocytes by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone. Diabetologia. 2006 Jun;49(6):1303-10. doi: 10.1007/s00125-006-0228-1. Epub 2006 Apr 12.
109 Rosiglitazone-Mediated Effects on Skeletal Muscle Gene Expression Correlate with Improvements in Insulin Sensitivity in Individuals with HIV-Insulin Resistance. Patholog Res Int. 2011 Apr 12;2011:736425. doi: 10.4061/2011/736425.
110 Changes in adiponectin receptor expression in muscle and adipose tissue of type 2 diabetic patients during rosiglitazone therapy. Diabetologia. 2005 Aug;48(8):1585-9. doi: 10.1007/s00125-005-1835-y. Epub 2005 Jul 1.
111 Bisphenol A and its derivatives decrease expression of chemerin, which reverses its stimulatory action in ovarian cancer cells. Toxicol Lett. 2018 Jul;291:61-69. doi: 10.1016/j.toxlet.2018.04.004. Epub 2018 Apr 10.
112 PPAR- activation attenuates deltamethrin-induced apoptosis by regulating cytosolic PINK1 and inhibiting mitochondrial dysfunction. Toxicol Lett. 2016 Oct 17;260:8-17. doi: 10.1016/j.toxlet.2016.08.016. Epub 2016 Aug 21.
113 Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression. Oncol Rep. 2008 Nov;20(5):1093-7.
114 Thiazolidinediones are potent inducers of fibroblast growth factor 21 expression in the liver. Biol Pharm Bull. 2011;34(7):1120-1. doi: 10.1248/bpb.34.1120.
115 Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway. J Clin Endocrinol Metab. 2005 Dec;90(12):6678-86. doi: 10.1210/jc.2005-0079. Epub 2005 Oct 4.
116 Discovery of a novel allelic variant of CYP2C8, CYP2C8*11, in Asian populations and its clinical effect on the rosiglitazone disposition in vivo. Drug Metab Dispos. 2011 Apr;39(4):711-6. doi: 10.1124/dmd.110.035899. Epub 2011 Jan 18.
117 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Diabetes Care. 2010 Oct;33(10):2250-3. doi: 10.2337/dc10-0452. Epub 2010 Jul 13.
118 LPIN1 genetic variation is associated with rosiglitazone response in type 2 diabetic patients. Mol Genet Metab. 2008 Sep-Oct;95(1-2):96-100. doi: 10.1016/j.ymgme.2008.06.011. Epub 2008 Aug 9.
119 Clinical pipeline report, company report or official report of Exelixis (2011).
120 Practical management of adverse events associated with cabozantinib treatment in patients with renal-cell carcinoma. Onco Targets Ther. 2017 Oct 19;10:5053-5064.
121 FDA Label of Cabozantinib. The 2020 official website of the U.S. Food and Drug Administration.
122 ROS-dependent DNA damage contributes to crizotinib-induced hepatotoxicity via the apoptotic pathway. Toxicol Appl Pharmacol. 2019 Nov 15;383:114768. doi: 10.1016/j.taap.2019.114768. Epub 2019 Oct 19.
123 Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes. Toxicol Lett. 2018 Jul;291:138-148. doi: 10.1016/j.toxlet.2018.04.010. Epub 2018 Apr 12.