Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6ITNG)

• Drug Name: Forskolin Drug Info
• Synonyms: forskolin; Colforsin; 66575-29-9; Coleonol; colforsina; colforsinum; colforsine; Boforsin; Colforsinum [Latin]; Colforsine [French]; Colforsina [Spanish]; Coleonolk; Colforsin [USAN:INN]; UNII-1F7A44V6OU; 7beta-Acetoxy-8,13-epoxy-1alpha,6beta,9alpha-trihydroxylabd-14-en-11-one; EINECS 266-410-9; HL 362; (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-benzo[f]chromen-5-yl acetate; NSC 357088; NSC 375489; Forskolin, Coleus forskohlii; CHEMBL52606; 1F7A44V6OU; L 75 1362B

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 47936
  ChEBI ID: CHEBI:42471
  CAS Number: CAS 66575-29-9
  TTD Drug ID: DM6ITNG

Molecule-Related Drug Atlas

Drug(s) Targeting Adenylate cyclase type 2 (ADCY2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE	DM5OYWF	Discovery agent	N.A.	Investigative	[2]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[10]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[11]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[12]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[13]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[14]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[16]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[17]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[18]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[20]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[21]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[22]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[23]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[24]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[25]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[26]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[27]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[28]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[26]

Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[29]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[30]
Methysergide	DM1EF73	Migraine	8A80	Approved	[31]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[32]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[37]

Drug(s) Affected By Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[44]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[45]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[46]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[47]

Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[48]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[50]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[17]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[52]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[50]

Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[60]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[61]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[62]

Drug(s) Affected By Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[55]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[64]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[64]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[65]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[66]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[66]
ABIRATERONE	DM8V75C	Prostate cancer	2C82.0	Approved	[67]

Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[71]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[70]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[73]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[74]

Drug(s) Affected By Acyl-CoA (FADS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[77]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[78]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[80]

Drug(s) Affected By Ecotropic viral integration site 5 protein homolog (EVI5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Selenium	DM25CGV	N. A.	N. A.	Approved	[82]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[85]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[86]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]

Drug(s) Affected By Transcription factor Maf (MAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[93]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[94]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[95]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[96]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[97]

Drug(s) Affected By E3 SUMO-protein ligase PIAS1 (PIAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[98]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[100]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[93]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[82]

Drug(s) Affected By Fatty acid CoA ligase Acsl3 (ACSL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[68]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[105]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[106]

Drug(s) Affected By Transmembrane protein 50A (TMEM50A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[109]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[110]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[111]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[112]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[6]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[113]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[114]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[115]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[116]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[68]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[119]

Drug(s) Affected By Prostate-specific antigen (KLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[17]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[120]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[124]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[125]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[127]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]

Drug(s) Affected By Guanine nucleotide-binding protein G(i) subunit alpha-3 (GNAI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Bortezomib	DMNO38U	Leukemia		Approved	[129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[130]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[109]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[131]

Drug(s) Affected By Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[132]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[132]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[132]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[133]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[134]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[135]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[136]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[138]

Drug(s) Affected By Integrin beta-5 (ITGB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[140]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[140]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[142]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]

Drug(s) Affected By Kallikrein-2 (KLK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[143]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[144]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[145]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[146]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[147]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[148]

Drug(s) Affected By Matrix metalloproteinase-16 (MMP16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[62]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[151]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[152]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[86]

Drug(s) Affected By Ataxin-3 (ATXN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[154]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[155]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[157]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[109]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[158]

Drug(s) Affected By Signal peptidase complex subunit 3 (SPCS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[85]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[93]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[159]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[161]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[162]

Drug(s) Affected By Translation initiation factor eIF2B subunit epsilon (EIF2B5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[163]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[165]

Drug(s) Affected By Ensconsin (MAP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[155]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[168]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[169]

Drug(s) Affected By Nuclear mitotic apparatus protein 1 (NUMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[128]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[172]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[173]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[174]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[175]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[176]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]

Drug(s) Affected By RRP12-like protein (RRP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[74]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[180]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[74]

Drug(s) Affected By Transcription termination factor 4, mitochondrial (MTERF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[129]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[174]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[109]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[181]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[6]

Drug(s) Affected By Zinc transporter 7 (SLC30A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[174]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[109]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[93]

Drug(s) Affected By Neuron navigator 1 (NAV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[184]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[142]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[78]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[185]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[100]

Drug(s) Affected By Amyloid protein-binding protein 2 (APPBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[174]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[109]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[93]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[82]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[187]

Drug(s) Affected By Dynein light chain 2, cytoplasmic (DYNLL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[188]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[189]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[93]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[110]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[190]

Drug(s) Affected By Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (NGLY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[174]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[169]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[191]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[6]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[74]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[85]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[192]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[109]

Drug(s) Affected By Trimethylguanosine synthase (TGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Indomethacin	DMSC4A7	Bursitis		Approved	[193]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[178]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[178]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[181]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[194]

Drug(s) Affected By Cell division control protein 6 homolog (CDC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[195]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[196]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[198]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[184]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 28 (MED28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[174]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[201]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[187]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[202]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[6]

Drug(s) Affected By Cardiolipin synthase (CRLS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[181]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[129]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[204]

Drug(s) Affected By Sestrin-1 (SESN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[206]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[207]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[208]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[74]

Drug(s) Affected By Steroid 21-hydroxylase (CYP21A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[209]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[174]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[110]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[210]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[191]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[211]
3-MeSO2-DDE	DMAWEQH	Discovery agent	N.A.	Investigative	[212]

Drug(s) Affected By 17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Metyrapone	DMI7FVQ	Cushing disease	5A70	Approved	[4]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[214]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[47]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[215]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[216]

Drug(s) Affected By Cytochrome P450 11B2, mitochondrial (CYP11B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[217]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[52]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Potassium Chloride	DMMTAJC	Hypokalemia	5C77	Approved	[219]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[145]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[220]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[218]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[43]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[221]

Drug(s) Affected By 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[63]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[66]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[66]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Metyrapone	DMI7FVQ	Cushing disease	5A70	Approved	[4]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[63]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[222]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[223]
Levetiracetam	DMTGDN8	Epilepsy	8A60-8A68	Approved	[43]

Drug(s) Affected By Peroxisomal multifunctional enzyme type 2 (HSD17B4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[213]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[213]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[128]
Haloperidol	DM96SE0	Delirium		Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[69]

Drug(s) Affected By Cytochrome P450 11B1, mitochondrial (CYP11B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[213]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[44]
Potassium Chloride	DMMTAJC	Hypokalemia	5C77	Approved	[219]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[212]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[225]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[225]

Drug(s) Affected By Sulfotransferase 2A1 (SULT2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[226]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[227]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]

Drug(s) Affected By Steroid hormone receptor ERR1 (ESRRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[230]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Bortezomib	DMNO38U	Leukemia		Approved	[129]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[231]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[232]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[232]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[233]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[234]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[235]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[236]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[237]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[238]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[239]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[240]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[241]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[242]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[243]

Drug(s) Affected By Epoxide hydrolase 1 (EPHX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[244]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[227]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[246]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]

Drug(s) Affected By Nuclear receptor subfamily 0 group B member 1 (NR0B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[147]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[17]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[248]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[249]

Drug(s) Affected By Adrenocorticotropic hormone receptor (MC2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[250]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[191]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[181]

Drug(s) Affected By Steroidogenic factor 1 (NR5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[44]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[251]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[252]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[253]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[254]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[255]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[191]
27-hydroxycholesterol	DM2L6OZ	Discovery agent	N.A.	Investigative	[256]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[257]

Drug(s) Affected By Sulfotransferase 2B1 (SULT2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[258]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[259]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[260]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[155]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[86]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[147]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[88]

Drug(s) Affected By Sulfotransferase 1E1 (SULT1E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[261]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[261]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[262]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[263]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[261]
Dienestrol	DMBSXI0	Atrophic vaginitis	GA30.2	Approved	[263]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[264]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[259]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[265]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[260]

Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[266]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[267]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[268]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[269]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[270]
Oxymetholone	DMFXUT8	Aplastic anemia	3A70	Approved	[271]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[109]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[272]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[273]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[274]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[274]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[272]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[272]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[275]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[276]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[278]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[239]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[279]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[280]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[281]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[241]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[282]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[282]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[283]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[284]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[285]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[282]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[282]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[282]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[286]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[287]

Drug(s) Affected By Choriogonadotropin subunit beta variant 1 (CGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[222]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[288]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[191]

Drug(s) Affected By Dynamin-1-like protein (DNM1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[289]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[291]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[292]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[293]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[204]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[289]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[294]

Drug(s) Affected By Nuclear receptor subfamily 5 group A member 2 (NR5A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[17]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[154]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[295]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[86]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[174]

Drug(s) Affected By Suppressor of cytokine signaling 3 (SOCS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[97]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[296]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[297]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Fedratinib	DM4ZBK6	Myelofibrosis	2A20.2	Approved	[298]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[298]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[297]

Drug(s) Affected By Probable proton-coupled zinc antiporter SLC30A4 (SLC30A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[259]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[109]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[190]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[299]

Drug(s) Affected By Proepiregulin (EREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[195]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[18]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[97]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[18]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[300]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[184]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[18]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 12A (PPP1R12A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[302]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[303]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[304]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[305]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[306]

Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[307]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[308]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[309]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[310]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[227]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[311]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[312]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 12 (ADAM12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[198]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[259]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[313]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[314]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[109]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[315]

Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[316]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[317]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]

Drug(s) Affected By Microphthalmia-associated transcription factor (MITF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[318]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[319]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[320]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[321]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[316]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[317]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[322]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[323]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[324]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[325]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[326]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[327]

Drug(s) Affected By Renin (REN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[328]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[329]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[330]
Reboxetine	DM26PRD	Depression	6A70-6A7Z	Approved	[331]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[332]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[333]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[334]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[335]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[336]
Chlorthalidone	DM4DMBT	Edema	MG29	Approved	[337]

Drug(s) Affected By Glycoprotein hormones alpha chain (CGA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Octreotide	DMHIDCJ	Acromegaly	5A60.0	Approved	[339]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[146]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[340]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[341]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[342]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[343]

Drug(s) Affected By Somatotropin (GH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[344]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[345]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[346]
Cyproheptadine	DM92AH3	Allergic rhinitis	CA08.0	Approved	[347]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Sodium oxybate	DMBOV5P	Narcolepsy	7A20	Approved	[348]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[344]
Connexyn	DMF29Q5	Attention deficit hyperactivity disorder	6A05.Z	Approved	[349]
Gamma Hydroxybutyric Acid	DMGBKVD	Narcolepsy	7A20	Approved	[350]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[351]

Drug(s) Affected By Gastrin (GAST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[352]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Terbutaline	DMD4381	Asthma	CA23	Approved	[353]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[352]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[260]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[352]
Lansoprazole	DMXYLQ3	Gastric ulcer	DA60	Approved	[354]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[233]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[116]

Drug(s) Affected By Interleukin-2 receptor subunit alpha (IL2RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[296]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[355]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[357]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[358]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[359]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[360]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[259]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[361]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[362]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[363]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[364]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[365]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[366]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[367]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[368]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[364]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[369]

Drug(s) Affected By Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[370]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[97]
Selenium	DM25CGV	N. A.	N. A.	Approved	[82]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[371]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[184]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[372]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[373]
Selenium	DM25CGV	N. A.	N. A.	Approved	[374]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[375]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[376]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[377]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[378]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[297]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[379]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[380]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[381]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[382]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[384]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[385]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[386]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[387]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[388]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[389]

Drug(s) Affected By Alkaline phosphatase, placental type (ALPP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[116]
Paricalcitol	DMYBV3G	Hyperparathyroidism	5A51	Approved	[116]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[323]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[390]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[391]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[392]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[393]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[394]

Drug(s) Affected By Corticoliberin (CRH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[395]
Meglitinides	DM1OFHN	Type-2 diabetes	5A11	Approved	[396]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[396]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[396]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Haloperidol	DM96SE0	Delirium		Approved	[396]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Terbutaline	DMD4381	Asthma	CA23	Approved	[397]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[396]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[288]

Drug(s) Affected By Tyrosine 3-monooxygenase (TH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zonisamide	DM0DTF7	Alcohol dependence	6C40.2	Approved	[398]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[400]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[401]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[62]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[402]
Methamphetamine	DMPM4SK	Anxiety		Approved	[403]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[404]

Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[405]
Bambuterol	DMKLSHF	Asthma	CA23	Approved	[406]
Terbutaline	DMD4381	Asthma	CA23	Approved	[407]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[408]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[409]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[410]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[411]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[412]

Drug(s) Affected By Zinc finger protein GLI1 (GLI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[413]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[414]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[415]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[416]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[417]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[418]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[419]

Drug(s) Affected By Complement decay-accelerating factor (CD55)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[420]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[421]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[184]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[380]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[422]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[423]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[82]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[302]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[184]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[182]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[424]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[98]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[424]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[74]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[425]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[426]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[427]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[428]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[429]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[429]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[430]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[431]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[432]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[433]

Drug(s) Affected By Insulin-like growth factor-binding protein 1 (IGFBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[17]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[434]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[435]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[436]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]

Drug(s) Affected By Fibroblast growth factor 2 (FGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[437]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[438]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[439]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[440]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[441]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[442]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[206]
Isradipine	DMA5XGH	Hypertension	BA00-BA04	Approved	[443]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[444]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[445]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[446]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[447]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[448]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[373]
Selenium	DM25CGV	N. A.	N. A.	Approved	[449]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[450]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[451]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[300]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[452]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[453]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[454]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[455]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[456]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[457]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[456]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[458]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[459]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[460]

Drug(s) Affected By Chorionic somatomammotropin hormone 1 (CSH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[97]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[461]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[462]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[463]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[84]

Drug(s) Affected By Chorionic somatomammotropin hormone 2 (CSH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[464]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[84]

Drug(s) Affected By Choriogonadotropin subunit beta 3 (CGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[391]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[465]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[466]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[288]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[466]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[467]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[468]

Drug(s) Affected By Choriogonadotropin subunit beta 7 (CGB7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[100]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[469]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[470]

Drug(s) Affected By Microtubule-associated protein 2 (MAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[471]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[472]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]

Drug(s) Affected By Fibroblast growth factor receptor 1 (FGFR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[436]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[473]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[473]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]

Drug(s) Affected By Pulmonary surfactant-associated protein C (SFTPC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[474]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[474]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[191]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[475]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[316]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[476]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[477]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[366]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[478]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[479]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]

Drug(s) Affected By Cystic fibrosis transmembrane conductance regulator (CFTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivacaftor	DMZC1HS	Cystic fibrosis	CA25	Approved	[480]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[97]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[481]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[482]
Miglustat	DM5J64S	Niemann-Pick disease type C		Approved	[483]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[484]
Milrinone	DM8TUPF	Congestive heart failure	BD10	Approved	[481]
Oxidized glutathione	DM9EQC0	Breast cancer	2C60-2C65	Approved	[485]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[485]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]

Drug(s) Affected By cAMP-dependent protein kinase type II-alpha regulatory subunit (PRKAR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[304]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[174]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[192]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[164]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[315]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[486]

Drug(s) Affected By Glial fibrillary acidic protein (GFAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillin V	DMKVOYF	Acute otitis media	AB00	Approved	[116]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[487]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[488]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[489]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Haloperidol	DM96SE0	Delirium		Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[461]

Drug(s) Affected By Amphiregulin (AREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[452]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[490]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[491]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[301]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[492]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[436]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[493]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[494]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[318]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[203]
Selenium	DM25CGV	N. A.	N. A.	Approved	[82]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[495]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[496]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[497]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[497]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[498]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[499]

Drug(s) Affected By Gap junction alpha-1 protein (GJA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[500]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[501]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[502]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[62]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[500]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[503]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[504]

Drug(s) Affected By cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[85]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[204]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[505]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[110]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[506]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[141]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[507]

Drug(s) Affected By Vascular endothelial growth factor receptor 1 (FLT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[508]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[509]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[510]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[167]
Haloperidol	DM96SE0	Delirium		Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[154]

Drug(s) Affected By Alpha-2C adrenergic receptor (ADRA2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[323]
Oxymetazoline	DM8ZXT6	Arrhythmia	BC9Z	Approved	[511]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[78]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[192]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[512]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]
Xylometazoline	DMKV32D	Allergic rhinitis	CA08.0	Phase 4	[511]

Drug(s) Affected By Syndecan-1 (SDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[196]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[513]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[142]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[514]

Drug(s) Affected By Interleukin-11 (IL11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[515]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[516]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[517]

Drug(s) Affected By Cannabinoid receptor 1 (CNR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[420]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[518]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[172]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[78]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[519]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[520]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]

Drug(s) Affected By Fibroblast growth factor receptor 2 (FGFR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[439]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[521]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[473]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[473]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[522]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[523]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[154]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[288]
Mirtazapine	DML53ZJ	Depression	6A70-6A7Z	Approved	[524]
Methamphetamine	DMPM4SK	Anxiety		Approved	[525]

Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[526]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[527]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[528]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[529]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]

Drug(s) Affected By Peroxiredoxin-2 (PRDX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[530]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[531]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[532]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[184]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[533]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[534]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]

Drug(s) Affected By Cannabinoid receptor 2 (CNR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Guanfacine extended release	DMB1CZ8	Attention deficit hyperactivity disorder	6A05.Z	Approved	[535]
NABILONE	DMVRYT2	Insomnia	7A00-7A0Z	Approved	[536]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[537]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[538]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[539]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[172]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[520]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[540]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[146]

Drug(s) Affected By Interleukin-13 (IL13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[541]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[542]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[543]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[544]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[545]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[546]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[547]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[544]
Ethambutol	DMR87LC	Pulmonary tuberculosis	1B10.Z	Approved	[545]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[548]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[549]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[550]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[551]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[552]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[553]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[554]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[555]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[13]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[556]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[557]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[558]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[559]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[560]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[561]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[562]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[563]

Drug(s) Affected By L-dopachrome tautomerase (DCT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[318]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[100]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[564]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[564]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[341]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[565]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[341]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[116]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[7]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[566]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[567]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[568]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[384]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[569]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[570]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[571]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[572]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[573]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[574]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 2 (NR4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[575]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[472]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[576]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[577]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[154]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[578]

Drug(s) Affected By Transcription factor SOX-2 (SOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[446]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[317]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[579]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[580]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[581]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[582]

Drug(s) Affected By Nestin (NES)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[438]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[583]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[402]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[304]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[163]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]

Drug(s) Affected By Placenta growth factor (PGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[584]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[78]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[87]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[175]

Drug(s) Affected By Protein Tob1 (TOB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[181]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[302]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[129]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[585]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]

Drug(s) Affected By Fibroblast growth factor 8 (FGF8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[586]
Ramelteon	DM7IW9J	Insomnia	7A00-7A0Z	Approved	[586]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Dolutegravir	DMCZGRE	Human immunodeficiency virus infection	1C62	Approved	[587]
Dabigatran	DMDI6R4	Stroke	8B20	Approved	[586]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[259]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[586]

Drug(s) Affected By Syncytin-2 (ERVFRD-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[391]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[588]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[341]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[341]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[341]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[3]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[588]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[111]
Anandamide	DMCKH3P	Discovery agent	N.A.	Investigative	[589]

Drug(s) Affected By Lysozyme C (LYZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[423]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[590]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[591]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[592]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[593]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[543]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[322]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[594]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[595]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[596]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[597]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]

Drug(s) Affected By Hepcidin (HAMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[267]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[598]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[599]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[600]
Papaverine	DMCA9QP	Brain ischaemia	8B1Z	Approved	[600]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[601]

Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[492]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Selenium	DM25CGV	N. A.	N. A.	Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[602]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[182]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[603]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[492]

Drug(s) Affected By Paired box protein Pax-8 (PAX8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[604]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[605]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[157]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[147]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[340]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[233]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[341]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[110]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[606]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[154]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[142]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[222]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[607]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[608]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[206]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]

Drug(s) Affected By Epidermal growth factor receptor kinase substrate 8 (EPS8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[609]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[163]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[78]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[610]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[611]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[612]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[613]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[302]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[300]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[184]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]

Drug(s) Affected By Growth arrest-specific protein 6 (GAS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[614]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[502]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[615]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[616]
Phosphate	DMUXQG7	Constipation	DD91.1	Approved	[614]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[617]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[189]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[618]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[614]

Drug(s) Affected By Latent-transforming growth factor beta-binding protein 2 (LTBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[259]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[86]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[109]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[169]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[341]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[341]

Drug(s) Affected By Neutral amino acid transporter B(0) (SLC1A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[196]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[74]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[196]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[74]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[196]

Drug(s) Affected By Survival motor neuron protein (SMN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[619]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[619]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[104]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[222]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[85]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[86]
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[619]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[147]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[620]

Drug(s) Affected By Kynurenine--oxoglutarate transaminase 1 (KYAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[155]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[470]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[187]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[181]
OXYQUINOLINE	DMZVS9Y	Discovery agent	N.A.	Investigative	[34]
L-methionine	DME8G1U	Discovery agent	N.A.	Investigative	[621]

Drug(s) Affected By Leukotriene C4 synthase (LTC4S)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[622]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[623]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[175]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[624]
Pranlukast	DMYHDCA	Allergic rhinitis	CA08.0	Approved	[625]
Etazolate	DMOCID7	Neurodegenerative disorder	8A20-8A23	Phase 2	[626]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[626]
ROLIPRAM	DMJ03UM	Discovery agent	N.A.	Investigative	[626]

Drug(s) Affected By Choriogonadotropin subunit beta variant 2 (CGB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[627]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[190]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[191]
norfluoxetine	DMKNUP3	Discovery agent	N.A.	Investigative	[628]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPARGC1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[629]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[11]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[85]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[86]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[100]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[192]

Drug(s) Affected By Patatin-like phospholipase domain-containing protein 6 (PNPLA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[74]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[74]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[630]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[108]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[260]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[86]

Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[17]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[631]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[629]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[632]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[633]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[634]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[635]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[636]
Mestranol	DMG3F94	Contraception	QA21	Approved	[637]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[638]

Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[639]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[640]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[641]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[642]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[307]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[523]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[643]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[644]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[645]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[174]

Drug(s) Affected By Sodium/iodide cotransporter (SLC5A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[646]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[647]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[648]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[604]
Tazarotene	DM8SMD1	Acne vulgaris	ED80	Approved	[649]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[649]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[649]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[650]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[651]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[649]

Drug(s) Affected By Mucin-4 (MUC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[652]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[653]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[141]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[654]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[653]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[655]

Drug(s) Affected By Proton-coupled zinc antiporter SLC30A2 (SLC30A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[656]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[147]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[109]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[315]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[657]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[191]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[187]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[657]

Drug(s) Affected By Eukaryotic translation initiation factor 5A-2 (EIF5A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[658]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[79]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[109]

Drug(s) Affected By Chorion-specific transcription factor GCMa (GCM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[391]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[659]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[233]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[110]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[191]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[181]
CHLORPYRIFOS	DMKPUI6	Discovery agent	N.A.	Investigative	[660]
T0070907	DMTKSVO	Discovery agent	N.A.	Investigative	[659]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Fructose	DM43AN2	Vomiting	MD90	Approved	[661]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[662]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[663]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[434]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[664]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[664]

Drug(s) Affected By Large neutral amino acids transporter small subunit 2 (SLC7A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Selenium	DM25CGV	N. A.	N. A.	Approved	[82]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[375]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[182]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[665]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[375]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[184]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[666]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[206]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[667]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[668]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[142]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[78]

Drug(s) Affected By Membrane-associated transporter protein (SLC45A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[7]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[470]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[187]
3-iodothyronamine	DM3L0F8	Discovery agent	N.A.	Investigative	[669]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[670]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[670]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[671]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[116]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[672]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[317]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[673]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[308]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[182]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[674]

Drug(s) Affected By Syncytin-1 (ERVW-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[391]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[588]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[675]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[88]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[588]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[111]
Anandamide	DMCKH3P	Discovery agent	N.A.	Investigative	[589]

Drug(s) Affected By Proton-coupled zinc antiporter SLC30A1 (SLC30A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[452]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[302]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[390]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[182]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[98]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[576]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[83]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[676]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[677]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[678]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[531]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[679]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[680]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[681]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[682]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[683]

Drug(s) Affected By Beta-1 adrenergic receptor (ADRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[684]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[685]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Vortioxetine	DM6F1PU	Major depressive disorder	6A70.3	Approved	[686]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[154]
Labetalol	DMK8U72	Hypertension	BA00-BA04	Approved	[687]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[688]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[490]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[109]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenylate cyclase type 2 (ADCY2)	TTBQ9IM	ADCY2_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)	OTHF4H9U	DHI2_HUMAN	Gene/Protein Processing	[3]
17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1)	OT6EBDHM	DHB1_HUMAN	Gene/Protein Processing	[4]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2)	OT02MSKN	3BHS2_HUMAN	Gene/Protein Processing	[4]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)	OTOA8WU2	PDE4B_HUMAN	Gene/Protein Processing	[5]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)	OT1RWFV0	PDE4D_HUMAN	Gene/Protein Processing	[5]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[6]
5,6-dihydroxyindole-2-carboxylic acid oxidase	OTRK49R4	TYRP1_HUMAN	Gene/Protein Processing	[7]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)	OTTLJH8W	ATS1_HUMAN	Gene/Protein Processing	[8]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[9]
Acyl-CoA (FADS1)	OTUYOYHX	FADS1_HUMAN	Gene/Protein Processing	[6]

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