Details of the Drug Combination

General Information of Drug Combination (ID: DCCF8S8)

Drug Combination Name
Bortezomib Irinotecan
Indication
Disease Entry Status REF
Recurrent Squamous Cell Carcinoma of the Hypopharynx Phase 1 [1]
Component Drugs Bortezomib   DMNO38U Irinotecan   DMP6SC2
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Bortezomib
Disease Entry ICD 11 Status REF
Leukemia N.A. Approved [2]
Lung cancer 2C25.0 Approved [2]
Lymphoproliferative syndrome N.A. Approved [2]
MALT lymphoma N.A. Approved [2]
Mantle cell lymphoma 2A85.5 Approved [3]
Minimally invasive lung adenocarcinoma N.A. Approved [2]
Multiple myeloma 2A83 Approved [4]
Nodal marginal zone lymphoma 2A85.0 Approved [2]
Plasma cell myeloma 2A83.1 Approved [2]
Recurrent adult burkitt lymphoma 2A85.6 Approved [2]
Non-hodgkin lymphoma 2B33.5 Phase 3 [4]
B-cell neoplasm N.A. Investigative [2]
Colon cancer 2B90.Z Investigative [2]
Gastric cancer 2B72 Investigative [2]
Bortezomib Interacts with 3 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Cationic trypsinogen (PRSS1) TT2WR1T TRY1_HUMAN Inhibitor [13]
Kallikrein-related peptidase (KLK) TT5L2VC NOUNIPROTAC Inhibitor [13]
Proteasome (PS) TTU7ZMG NOUNIPROTAC Modulator [14]
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Bortezomib Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [15]
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Bortezomib Interacts with 5 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [16]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [17]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [18]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [19]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [18]
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Bortezomib Interacts with 686 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Expression [20]
Extended synaptotagmin-2 (ESYT2) OTWCXTX3 ESYT2_HUMAN Decreases Expression [7]
Alternative prion protein (PRNP) OTE85L1Q APRIO_HUMAN Increases Expression [7]
Serine/threonine-protein kinase Sgk1 (SGK1) OT301T1U SGK1_HUMAN Increases Expression [7]
Cytosolic acyl coenzyme A thioester hydrolase (ACOT7) OT7C68YV BACH_HUMAN Decreases Expression [7]
GTP-binding protein 1 (GTPBP1) OTA9KV6C GTPB1_HUMAN Decreases Expression [7]
Galectin-8 (LGALS8) OT71LJ8T LEG8_HUMAN Increases Expression [7]
26S proteasome non-ATPase regulatory subunit 12 (PSMD12) OTWICA51 PSD12_HUMAN Increases Expression [7]
Leukocyte-specific transcript 1 protein (LST1) OTUVG424 LST1_HUMAN Decreases Expression [7]
Agrin (AGRN) OTWJENAZ AGRIN_HUMAN Decreases Expression [7]
Krev interaction trapped protein 1 (KRIT1) OT58AP1I KRIT1_HUMAN Increases Expression [7]
Beta-1,3-N-acetylglucosaminyltransferase manic fringe (MFNG) OTUX45ZF MFNG_HUMAN Decreases Expression [7]
Pirin (PIR) OT8ALXHU PIR_HUMAN Increases Expression [7]
Pyridoxal kinase (PDXK) OT40AJ5J PDXK_HUMAN Increases Expression [7]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Decreases Expression [7]
Suppressor of cytokine signaling 3 (SOCS3) OTY183WJ SOCS3_HUMAN Increases Expression [7]
TRAF-type zinc finger domain-containing protein 1 (TRAFD1) OT7AU2R3 TRAD1_HUMAN Increases Expression [7]
Cytoplasmic dynein 1 intermediate chain 1 (DYNC1I1) OTFX1KCG DC1I1_HUMAN Increases Expression [7]
Chromodomain-helicase-DNA-binding protein 2 (CHD2) OTRKL6YC CHD2_HUMAN Increases Expression [7]
Golgi SNAP receptor complex member 2 (GOSR2) OTYHIYN2 GOSR2_HUMAN Increases Expression [7]
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) OTOKUXUH ADA10_HUMAN Decreases Expression [7]
Apolipoprotein L1 (APOL1) OT8QBVTY APOL1_HUMAN Increases Expression [7]
Interferon-inducible protein AIM2 (AIM2) OT86QUI8 AIM2_HUMAN Increases Expression [7]
Myosin regulatory light chain 12B (MYL12B) OTXMLQOT ML12B_HUMAN Increases Expression [7]
Centrosomal protein of 290 kDa (CEP290) OTVN52VH CE290_HUMAN Increases Expression [7]
Small ribosomal subunit protein uS12m (MRPS12) OTGY4GIX RT12_HUMAN Decreases Expression [7]
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) OT1Z1ZXE OGT1_HUMAN Decreases Expression [7]
V-type proton ATPase subunit e 1 (ATP6V0E1) OTZZIUYY VA0E1_HUMAN Increases Expression [7]
ATP-binding cassette sub-family C member 4 (ABCC4) OTO27PAL MRP4_HUMAN Decreases Expression [7]
Transcription factor MafG (MAFG) OTBQFUZH MAFG_HUMAN Increases Expression [7]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2) OT6Y1QZN IRAK2_HUMAN Increases Expression [7]
PHD finger protein 1 (PHF1) OTW2PSIR PHF1_HUMAN Increases Expression [7]
Synaptogyrin-2 (SYNGR2) OTJX84RI SNG2_HUMAN Decreases Expression [7]
Cytohesin-interacting protein (CYTIP) OTRJ3ZC5 CYTIP_HUMAN Increases Expression [7]
Growth arrest-specific protein 7 (GAS7) OT0M5TNY GAS7_HUMAN Decreases Expression [7]
F-box-like/WD repeat-containing protein TBL1X (TBL1X) OTXQ51E0 TBL1X_HUMAN Increases Expression [7]
Glycosaminoglycan xylosylkinase (FAM20B) OTOA0UYT XYLK_HUMAN Decreases Expression [7]
Suppressor of cytokine signaling 5 (SOCS5) OTN1ABYR SOCS5_HUMAN Increases Expression [7]
Protein tyrosine phosphatase type IVA 3 (PTP4A3) OTXMMWUN TP4A3_HUMAN Decreases Expression [7]
Deformed epidermal autoregulatory factor 1 homolog (DEAF1) OTCLX3ZW DEAF1_HUMAN Decreases Expression [7]
Calpain-15 (CAPN15) OT0WE161 CAN15_HUMAN Decreases Expression [7]
Carbonyl reductase 3 (CBR3) OT9G6SF0 CBR3_HUMAN Increases Expression [7]
Triple functional domain protein (TRIO) OT71X1AK TRIO_HUMAN Decreases Expression [7]
Cystatin-F (CST7) OTQWZUVQ CYTF_HUMAN Increases Expression [7]
ATP-dependent DNA helicase Q4 (RECQL4) OT59LSW7 RECQ4_HUMAN Increases Expression [7]
Erlin-2 (ERLIN2) OT551BVG ERLN2_HUMAN Decreases Expression [7]
Pre-mRNA-processing factor 6 (PRPF6) OT3U0ABN PRP6_HUMAN Decreases Expression [7]
Lysine-specific demethylase 4B (KDM4B) OT5P1UPY KDM4B_HUMAN Decreases Expression [7]
Methyl-CpG-binding domain protein 4 (MBD4) OTWR9YXE MBD4_HUMAN Increases Expression [7]
Arginyl-tRNA--protein transferase 1 (ATE1) OT3QNM39 ATE1_HUMAN Increases Expression [7]
GDH/6PGL endoplasmic bifunctional protein (H6PD) OTO7TNDD G6PE_HUMAN Decreases Expression [7]
NAD kinase (NADK) OTYN9GX0 NADK_HUMAN Decreases Expression [7]
AP-2 complex subunit alpha-1 (AP2A1) OTEFZB21 AP2A1_HUMAN Decreases Expression [7]
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) OTBMJUOC M4K4_HUMAN Increases Expression [7]
Acyl-CoA 6-desaturase (FADS2) OTUX531P FADS2_HUMAN Decreases Expression [7]
Phosphatidylserine lipase ABHD16A (ABHD16A) OTDS9K1Z ABHGA_HUMAN Increases Expression [7]
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) OT1TN2KT GPAN1_HUMAN Increases Expression [7]
Putative lipid scramblase CLPTM1 (CLPTM1) OT14QP7N CLPT1_HUMAN Decreases Expression [7]
Glutathione reductase, mitochondrial (GSR) OTM2TUYM GSHR_HUMAN Increases Expression [7]
HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA) OT7KZMP2 DRA_HUMAN Decreases Expression [7]
Myelin basic protein (MBP) OTFZCEDB MBP_HUMAN Decreases Expression [7]
Thy-1 membrane glycoprotein (THY1) OTVONVTB THY1_HUMAN Decreases Expression [7]
HLA class II histocompatibility antigen, DP beta 1 chain (HLA-DPB1) OTW8JHU2 DPB1_HUMAN Decreases Expression [7]
T-cell surface glycoprotein CD5 (CD5) OTC5JEG5 CD5_HUMAN Decreases Expression [7]
Alpha-galactosidase A (GLA) OTBSR6DT AGAL_HUMAN Increases Expression [7]
HLA class II histocompatibility antigen, DO alpha chain (HLA-DOA) OTZE5Q7R DOA_HUMAN Decreases Expression [7]
Cathepsin D (CTSD) OTQZ36F3 CATD_HUMAN Increases Expression [7]
Trypsin-2 (PRSS2) OTOMVUWL TRY2_HUMAN Decreases Expression [7]
Prosaposin (PSAP) OTUOEKY7 SAP_HUMAN Increases Expression [7]
Guanine nucleotide-binding protein G(i) subunit alpha-3 (GNAI3) OT89UWAR GNAI3_HUMAN Increases Expression [7]
Steryl-sulfatase (STS) OTXTJQPC STS_HUMAN Decreases Expression [7]
Monoacylglycerol lipase ABHD2 (ABHD2) OTCRUOCS ABHD2_HUMAN Increases Expression [7]
Gamma-enolase (ENO2) OTRODL0T ENOG_HUMAN Increases Expression [7]
Tropomyosin alpha-1 chain (TPM1) OTD73X6R TPM1_HUMAN Increases Expression [7]
Cancer/testis antigen family 45 member A6 (CT45A5) OTIFETOM CT456_HUMAN Increases Expression [7]
Schwannomin-interacting protein 1 (SCHIP1) OTF3FR4A SCHI1_HUMAN Decreases Expression [7]
Granzyme B (GZMB) OTPPVIRS GRAB_HUMAN Increases Expression [7]
Clusterin (CLU) OTQGG0JM CLUS_HUMAN Increases Expression [7]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Increases Expression [7]
Phenylethanolamine N-methyltransferase (PNMT) OTGLCPE8 PNMT_HUMAN Decreases Expression [7]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) OT2HZK5M GTR3_HUMAN Increases Expression [7]
Ras-related protein Ral-A (RALA) OT734R7X RALA_HUMAN Increases Expression [7]
Breakpoint cluster region protein (BCR) OTCN76C1 BCR_HUMAN Decreases Expression [7]
Glucose-6-phosphate 1-dehydrogenase (G6PD) OT300SMK G6PD_HUMAN Decreases Expression [7]
Steroid hormone receptor ERR1 (ESRRA) OTTDTUSP ERR1_HUMAN Decreases Expression [7]
B-cell antigen receptor complex-associated protein alpha chain (CD79A) OTOJC8DV CD79A_HUMAN Decreases Expression [7]
Granzyme A (GZMA) OT43R33L GRAA_HUMAN Decreases Expression [7]
Cytochrome b-245 light chain (CYBA) OT16N9ZO CY24A_HUMAN Decreases Expression [7]
Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3) OTM8EG6H AT1A3_HUMAN Decreases Expression [7]
Perforin-1 (PRF1) OTFVXD7H PERF_HUMAN Decreases Expression [7]
Insulin-degrading enzyme (IDE) OT5GQTJ5 IDE_HUMAN Increases Expression [7]
Ras-related C3 botulinum toxin substrate 2 (RAC2) OTAOHFNH RAC2_HUMAN Decreases Expression [7]
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) OT18H1B0 ERF3A_HUMAN Decreases Expression [7]
Folate receptor alpha (FOLR1) OT0QZ0H6 FOLR1_HUMAN Decreases Expression [7]
Cyclic AMP-dependent transcription factor ATF-2 (ATF2) OTNIZPEA ATF2_HUMAN Increases Expression [7]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Increases Expression [7]
Immunoglobulin lambda-like polypeptide 1 (IGLL1) OTRTNVOG IGLL1_HUMAN Decreases Expression [7]
Mucin-1 (MUC1) OTHQI7IY MUC1_HUMAN Decreases Expression [7]
Ribosyldihydronicotinamide dehydrogenase (NQO2) OTGDAJRZ NQO2_HUMAN Increases Expression [7]
Leukosialin (SPN) OTFW338K LEUK_HUMAN Decreases Expression [7]
Transcription factor JunD (JUND) OTNKACJD JUND_HUMAN Decreases Expression [7]
Integrin beta-6 (ITGB6) OTI3DJ7U ITB6_HUMAN Increases Expression [7]
Ras-related protein Rab-5A (RAB5A) OTFR2KM4 RAB5A_HUMAN Decreases Expression [7]
Integrin alpha-L (ITGAL) OTCUQAIS ITAL_HUMAN Decreases Expression [7]
B-cell lymphoma 3 protein (BCL3) OT1M5B95 BCL3_HUMAN Decreases Expression [7]
5'-nucleotidase (NT5E) OT7J5LT6 5NTD_HUMAN Decreases Expression [7]
Ephrin type-A receptor 1 (EPHA1) OTGJMRZ0 EPHA1_HUMAN Decreases Expression [7]
CD9 antigen (CD9) OT2184XU CD9_HUMAN Increases Expression [7]
Integrin alpha-6 (ITGA6) OT3FA39C ITA6_HUMAN Decreases Expression [7]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Increases Expression [7]
Tyrosine-protein kinase JAK1 (JAK1) OT0X3D17 JAK1_HUMAN Decreases Expression [7]
ER lumen protein-retaining receptor 1 (KDELR1) OT8YBS5G ERD21_HUMAN Decreases Expression [7]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [7]
Polypyrimidine tract-binding protein 1 (PTBP1) OT2OBJUK PTBP1_HUMAN Decreases Expression [7]
NKG2-D type II integral membrane protein (KLRK1) OTQWXK71 NKG2D_HUMAN Decreases Expression [7]
CD82 antigen (CD82) OTH8MC64 CD82_HUMAN Decreases Expression [7]
HLA class II histocompatibility antigen, DM beta chain (HLA-DMB) OT17HGXJ DMB_HUMAN Decreases Expression [7]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) OTG0TTX7 CD38_HUMAN Decreases Expression [7]
Ephrin type-B receptor 2 (EPHB2) OT8VZ6C5 EPHB2_HUMAN Decreases Expression [7]
Flavin reductase (BLVRB) OTHCFN2C BLVRB_HUMAN Increases Expression [7]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Decreases Expression [7]
Homeobox protein Hox-A11 (HOXA11) OT42C4HF HXA11_HUMAN Decreases Expression [7]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [7]
Stress-induced-phosphoprotein 1 (STIP1) OT7TXLOX STIP1_HUMAN Decreases Expression [7]
Guanylate-binding protein 2 (GBP2) OTVU4G07 GBP2_HUMAN Increases Expression [7]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Decreases Expression [7]
Protein phosphatase 1A (PPM1A) OT1U770U PPM1A_HUMAN Increases Expression [7]
Transcription factor 7 (TCF7) OT1ID822 TCF7_HUMAN Decreases Expression [7]
Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) OTUE7Z91 MP2K2_HUMAN Decreases Expression [7]
Transgelin-2 (TAGLN2) OTUXZGDQ TAGL2_HUMAN Decreases Expression [7]
Pre-B-cell leukemia transcription factor 3 (PBX3) OT8WMVM4 PBX3_HUMAN Decreases Expression [7]
Interleukin-15 (IL15) OTQSYWQS IL15_HUMAN Increases Expression [7]
Trifunctional enzyme subunit alpha, mitochondrial (HADHA) OTO557N2 ECHA_HUMAN Increases Expression [7]
Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) OTARRES9 IF2G_HUMAN Decreases Expression [7]
B-cell lymphoma 6 protein (BCL6) OTQAWWO1 BCL6_HUMAN Increases Expression [7]
Lysine-specific demethylase 5C (KDM5C) OTZ6E0HY KDM5C_HUMAN Decreases Expression [7]
Eukaryotic translation initiation factor 1 (EIF1) OTB4GZ0V EIF1_HUMAN Increases Expression [7]
5-hydroxytryptamine receptor 2B (HTR2B) OTM1AD9J 5HT2B_HUMAN Decreases Expression [7]
Lamina-associated polypeptide 2, isoform alpha (TMPO) OTL68EL4 LAP2A_HUMAN Decreases Expression [7]
ETS translocation variant 4 (ETV4) OT8C98UZ ETV4_HUMAN Decreases Expression [7]
Killer cell immunoglobulin-like receptor 2DS4 (KIR2DS4) OT00N6UJ KI2S4_HUMAN Decreases Expression [7]
26S proteasome regulatory subunit 6B (PSMC4) OTS3XN41 PRS6B_HUMAN Increases Expression [7]
Lys-63-specific deubiquitinase BRCC36 (BRCC3) OTK0ZN7Y BRCC3_HUMAN Decreases Expression [7]
LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1) OT729S0T LIMS1_HUMAN Increases Expression [7]
NADP-dependent malic enzyme (ME1) OTSVEUQE MAOX_HUMAN Increases Expression [7]
MAP kinase-activated protein kinase 2 (MAPKAPK2) OT460SBO MAPK2_HUMAN Decreases Expression [7]
Large ribosomal subunit protein bL19m (MRPL19) OTRBKF6R RM19_HUMAN Increases Expression [7]
Beta-arrestin-1 (ARRB1) OT2NJS37 ARRB1_HUMAN Decreases Expression [7]
Ubiquitin-conjugating enzyme E2 R1 (CDC34) OTNBK390 UB2R1_HUMAN Increases Expression [7]
Choline-phosphate cytidylyltransferase A (PCYT1A) OTMH0YLN PCY1A_HUMAN Increases Expression [7]
Protein phosphatase 1F (PPM1F) OTU0MVR7 PPM1F_HUMAN Increases Expression [7]
Protein numb homolog (NUMB) OTMB586Q NUMB_HUMAN Increases Expression [7]
Presenilin-1 (PSEN1) OTKL39RT PSN1_HUMAN Decreases Expression [7]
Cytosolic purine 5'-nucleotidase (NT5C2) OTJMF66Z 5NTC_HUMAN Increases Expression [7]
DNA ligase 4 (LIG4) OT40DNXU DNLI4_HUMAN Increases Expression [7]
Dynamin-2 (DNM2) OTUYU2U3 DYN2_HUMAN Decreases Expression [7]
Poly(A) polymerase alpha (PAPOLA) OTPHD65D PAPOA_HUMAN Decreases Expression [7]
Tyrosine-protein kinase Blk (BLK) OT1EB8MT BLK_HUMAN Decreases Expression [7]
Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1) OTF3TBTK SSDH_HUMAN Decreases Expression [7]
26S proteasome non-ATPase regulatory subunit 7 (PSMD7) OT7PZZ4K PSMD7_HUMAN Increases Expression [7]
N-sulphoglucosamine sulphohydrolase (SGSH) OTLSSEOS SPHM_HUMAN Increases Expression [7]
AF4/FMR2 family member 1 (AFF1) OTT2C78E AFF1_HUMAN Increases Expression [7]
Importin subunit alpha-1 (KPNA2) OTU7FOE6 IMA1_HUMAN Increases Expression [7]
Diacylglycerol kinase epsilon (DGKE) OTWS86AS DGKE_HUMAN Decreases Expression [7]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6) OTK13JKC MP2K6_HUMAN Decreases Expression [7]
Rho GDP-dissociation inhibitor 1 (ARHGDIA) OTEXWJDO GDIR1_HUMAN Decreases Expression [7]
Cysteine-rich protein 2 (CRIP2) OTVVJSYX CRIP2_HUMAN Decreases Expression [7]
Serine/threonine-protein phosphatase 5 (PPP5C) OTC3HT6Y PPP5_HUMAN Decreases Expression [7]
Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1) OT6W40XU P5CS_HUMAN Decreases Expression [7]
Proteinase-activated receptor 2 (F2RL1) OTMRMJ8N PAR2_HUMAN Decreases Expression [7]
Myc-associated zinc finger protein (MAZ) OTEHKN1M MAZ_HUMAN Decreases Expression [7]
ADP-ribosylation factor-like protein 4C (ARL4C) OTQ3QNNU ARL4C_HUMAN Decreases Expression [7]
Small integral membrane protein 11 (SMIM11) OTZPLVUC SIM11_HUMAN Decreases Expression [7]
Triosephosphate isomerase (TPI1) OT14KP4B TPIS_HUMAN Increases Expression [7]
Cell division control protein 42 homolog (CDC42) OT5QBC5M CDC42_HUMAN Decreases Expression [7]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Decreases Expression [7]
Large ribosomal subunit protein uL24 (RPL26) OTFNRC27 RL26_HUMAN Increases Expression [7]
cAMP-dependent protein kinase inhibitor alpha (PKIA) OT8M5GVO IPKA_HUMAN Increases Expression [7]
AP-1 complex subunit sigma-1A (AP1S1) OTQ2H8DN AP1S1_HUMAN Decreases Expression [7]
Small ribosomal subunit protein uS17 (RPS11) OTILZE44 RS11_HUMAN Increases Expression [7]
ADP-ribosylation factor 6 (ARF6) OTVV7KJO ARF6_HUMAN Increases Expression [7]
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) OT6285L4 FKB1A_HUMAN Decreases Expression [7]
Calcineurin subunit B type 1 (PPP3R1) OTGQNFJQ CANB1_HUMAN Decreases Expression [7]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A) OT9297OG 2ABA_HUMAN Increases Expression [7]
Small ubiquitin-related modifier 1 (SUMO1) OTJFD4P5 SUMO1_HUMAN Increases Expression [7]
Eukaryotic translation initiation factor 5A-1 (EIF5A) OTQ8DJX5 IF5A1_HUMAN Decreases Expression [7]
DNA-dependent protein kinase catalytic subunit (PRKDC) OTJVS4EG PRKDC_HUMAN Decreases Expression [7]
Small ribosomal subunit protein uS5m (MRPS5) OTZZR208 RT05_HUMAN Decreases Expression [7]
Spectrin beta chain, non-erythrocytic 1 (SPTBN1) OTOVM4D4 SPTB2_HUMAN Increases Expression [7]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Decreases Expression [7]
2-oxoglutarate dehydrogenase complex component E1 (OGDH) OTHGTQWF ODO1_HUMAN Decreases Expression [7]
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase , mitochondrial (ALDH6A1) OT8LCZCT MMSA_HUMAN Decreases Expression [7]
Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11) OT7EVFBK M2OM_HUMAN Decreases Expression [7]
Glutathione S-transferase Mu 4 (GSTM4) OTOTF8DU GSTM4_HUMAN Decreases Expression [7]
cAMP-responsive element modulator (CREM) OTJIJ5AL CREM_HUMAN Increases Expression [7]
Centromere protein C (CENPC) OTVJ6VE9 CENPC_HUMAN Increases Expression [7]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Expression [7]
Neurogenic locus notch homolog protein 2 (NOTCH2) OTQ3Y9PA NOTC2_HUMAN Decreases Expression [7]
CTD small phosphatase-like protein 2 (CTDSPL2) OTPF8W4P CTSL2_HUMAN Decreases Expression [7]
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) OTFH9M73 PTN11_HUMAN Decreases Expression [7]
Early activation antigen CD69 (CD69) OTGJHSVP CD69_HUMAN Increases Expression [7]
Serine/arginine-rich splicing factor 1 (SRSF1) OTF61HOV SRSF1_HUMAN Decreases Expression [7]
Rho GTPase-activating protein 1 (ARHGAP1) OT0H2ZBZ RHG01_HUMAN Decreases Expression [7]
FACT complex subunit SSRP1 (SSRP1) OT5TYJK9 SSRP1_HUMAN Decreases Expression [7]
Sodium/bile acid cotransporter 7 (SLC10A7) OTYLAWNV NTCP7_HUMAN Increases Expression [7]
Apolipoprotein B receptor (APOBR) OT9EUZX3 APOBR_HUMAN Decreases Expression [7]
Nuclear factor 1 A-type (NFIA) OTDHQ9CG NFIA_HUMAN Decreases Expression [7]
Interferon-related developmental regulator 2 (IFRD2) OT2URF18 IFRD2_HUMAN Decreases Expression [7]
Protein AF1q (MLLT11) OTG5RVHC AF1Q_HUMAN Increases Expression [7]
PR domain zinc finger protein 2 (PRDM2) OT8L7CGX PRDM2_HUMAN Decreases Expression [7]
Dual specificity protein phosphatase 4 (DUSP4) OT6WAO12 DUS4_HUMAN Decreases Expression [7]
Oxysterols receptor LXR-alpha (NR1H3) OT54YZ9I NR1H3_HUMAN Decreases Expression [7]
Chromobox protein homolog 3 (CBX3) OTOP9RLD CBX3_HUMAN Increases Expression [7]
Phosducin-like protein (PDCL) OTDNHIXG PHLP_HUMAN Increases Expression [7]
DNA-binding protein Ikaros (IKZF1) OTCW1FKL IKZF1_HUMAN Decreases Expression [7]
Protein OS-9 (OS9) OTB5B2TY OS9_HUMAN Increases Expression [7]
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5) OT404F9K FKBP5_HUMAN Decreases Expression [7]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Increases Expression [7]
Transformer-2 protein homolog alpha (TRA2A) OT5NHOO3 TRA2A_HUMAN Decreases Expression [7]
Rap guanine nucleotide exchange factor 1 (RAPGEF1) OTZ0TBN1 RPGF1_HUMAN Decreases Expression [7]
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (PDE7A) OTVDV4IT PDE7A_HUMAN Decreases Expression [7]
Nuclear transcription factor Y subunit gamma (NFYC) OTZVVEV7 NFYC_HUMAN Decreases Expression [7]
Transcription factor Dp-1 (TFDP1) OT6RZ7VT TFDP1_HUMAN Decreases Expression [7]
Fas-activated serine/threonine kinase (FASTK) OTTHFZMP FASTK_HUMAN Decreases Expression [7]
Mediator of DNA damage checkpoint protein 1 (MDC1) OTEUQH4J MDC1_HUMAN Decreases Expression [7]
Structural maintenance of chromosomes protein 1A (SMC1A) OT9ZMRK9 SMC1A_HUMAN Decreases Expression [7]
Neutral alpha-glucosidase AB (GANAB) OTYLXY4M GANAB_HUMAN Decreases Expression [7]
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) OT43TTX0 2A5D_HUMAN Decreases Expression [7]
Kinesin-like protein KIF22 (KIF22) OTY6X6BL KIF22_HUMAN Decreases Expression [7]
Killer cell immunoglobulin-like receptor 3DS1 (KIR3DS1) OTJWIO4T KI3S1_HUMAN Decreases Expression [7]
Killer cell immunoglobulin-like receptor 2DS3 (KIR2DS3) OT3PSLDL KI2S3_HUMAN Decreases Expression [7]
DAZ-associated protein 2 (DAZAP2) OTNURO9F DAZP2_HUMAN Decreases Expression [7]
Neutrophil cytosol factor 4 (NCF4) OTX007YL NCF4_HUMAN Decreases Expression [7]
kinase isozyme 2, mitochondrial (PDK2) OTM436F9 PDK2_HUMAN Decreases Expression [7]
Leucine-rich repeat-containing protein 41 (LRRC41) OT4YSBV5 LRC41_HUMAN Decreases Expression [7]
Ras suppressor protein 1 (RSU1) OTO5GHT1 RSU1_HUMAN Increases Expression [7]
Scaffold attachment factor B1 (SAFB) OTGRV2LW SAFB1_HUMAN Decreases Expression [7]
NF-kappa-B inhibitor beta (NFKBIB) OTY1ZJXH IKBB_HUMAN Increases Expression [7]
NGFI-A-binding protein 2 (NAB2) OTG4BDF3 NAB2_HUMAN Decreases Expression [7]
Neuronal pentraxin-1 (NPTX1) OTKVHCV0 NPTX1_HUMAN Decreases Expression [7]
Coiled-coil domain-containing protein 6 (CCDC6) OTXRQDYG CCDC6_HUMAN Decreases Expression [7]
Drebrin (DBN1) OTZVKG8A DREB_HUMAN Increases Expression [7]
Solute carrier family 35 member G1 (SLC35G1) OTKZUA8O S35G1_HUMAN Decreases Expression [7]
Protein mono-ADP-ribosyltransferase PARP6 (PARP6) OTWSXW4O PARP6_HUMAN Decreases Expression [7]
Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) OTN7XAUD LRRF1_HUMAN Increases Expression [7]
Polycomb group RING finger protein 3 (PCGF3) OTY7TPPZ PCGF3_HUMAN Increases Expression [7]
NAD kinase 2, mitochondrial (NADK2) OT1I8GDE NAKD2_HUMAN Increases Expression [7]
B-cell CLL/lymphoma 7 protein family member A (BCL7A) OTYFUJTP BCL7A_HUMAN Decreases Expression [7]
Glycerol-3-phosphate acyltransferase 3 (GPAT3) OTJUGPK0 GPAT3_HUMAN Increases Expression [7]
Acylglycerol kinase, mitochondrial (AGK) OTJGWBYT AGK_HUMAN Decreases Expression [7]
Vesicle transport protein SFT2C (SFT2D3) OT0IEAAR SFT2C_HUMAN Decreases Expression [7]
Transmembrane protein 41B (TMEM41B) OTW0B0KS TM41B_HUMAN Increases Expression [7]
Torsin-1A-interacting protein 1 (TOR1AIP1) OTTG8MAK TOIP1_HUMAN Decreases Expression [7]
Tetratricopeptide repeat protein 39A (TTC39A) OT80PQWX TT39A_HUMAN Increases Expression [7]
Protein furry homolog (FRY) OT74IAG2 FRY_HUMAN Increases Expression [7]
Probable E3 ubiquitin-protein ligase HECTD2 (HECTD2) OTDIBGQV HECD2_HUMAN Increases Expression [7]
G-protein coupled receptor 157 (GPR157) OTE7K9D7 GP157_HUMAN Decreases Expression [7]
Obscurin (OBSCN) OTT14OVX OBSCN_HUMAN Decreases Expression [7]
G kinase-anchoring protein 1 (GKAP1) OTHZRJ56 GKAP1_HUMAN Increases Expression [7]
Protein TASOR 2 (TASOR2) OTN4VE8H TASO2_HUMAN Decreases Expression [7]
Sushi domain-containing protein 4 (SUSD4) OTWCJTT3 SUSD4_HUMAN Decreases Expression [7]
Proteasome adapter and scaffold protein ECM29 (ECPAS) OT1C0KOI ECM29_HUMAN Increases Expression [7]
DENN domain-containing protein 4C (DENND4C) OT8SYN47 DEN4C_HUMAN Increases Expression [7]
Pecanex-like protein 4 (PCNX4) OTV474RQ PCX4_HUMAN Increases Expression [7]
Protein SPT2 homolog (SPTY2D1) OT1RY99Z SPT2_HUMAN Increases Expression [7]
CWF19-like protein 1 (CWF19L1) OTAMYTOW C19L1_HUMAN Decreases Expression [7]
U11/U12 small nuclear ribonucleoprotein 48 kDa protein (SNRNP48) OTSR6DEJ SNR48_HUMAN Increases Expression [7]
Tyrosine-protein kinase STYK1 (STYK1) OT61CSU7 STYK1_HUMAN Increases Expression [7]
SPRY domain-containing SOCS box protein 3 (SPSB3) OTHGEE2K SPSB3_HUMAN Increases Expression [7]
E3 ubiquitin-protein ligase TRIM65 (TRIM65) OTSQTK3A TRI65_HUMAN Decreases Expression [7]
Leucine-rich repeat and fibronectin type-III domain-containing protein 4 (LRFN4) OT7RWBKE LRFN4_HUMAN Decreases Expression [7]
Type-1 angiotensin II receptor-associated protein (AGTRAP) OT02N7LD ATRAP_HUMAN Decreases Expression [7]
Transmembrane protein 92 (TMEM92) OTTKJ2C0 TMM92_HUMAN Decreases Expression [7]
MICOS complex subunit MIC27 (APOOL) OTC1WT8O MIC27_HUMAN Increases Expression [7]
DnaJ homolog subfamily C member 14 (DNAJC14) OT7DPIVN DJC14_HUMAN Decreases Expression [7]
TBC1 domain family member 9 (TBC1D9) OTSSCTB5 TBCD9_HUMAN Increases Expression [7]
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) OTMQXW7S RAPH1_HUMAN Increases Expression [7]
Serine/threonine-protein kinase MARK2 (MARK2) OTJWGLUZ MARK2_HUMAN Decreases Expression [7]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) OTE8GBUR RIR2B_HUMAN Increases Expression [7]
Probable C-mannosyltransferase DPY19L4 (DPY19L4) OTQ89TXA D19L4_HUMAN Increases Expression [7]
Coiled-coil domain-containing protein 186 (CCDC186) OTONSQAD CC186_HUMAN Increases Expression [7]
C-myc promoter-binding protein (DENND4A) OT8FFZ29 MYCPP_HUMAN Increases Expression [7]
Cytochrome P450 2U1 (CYP2U1) OT6RXLXS CP2U1_HUMAN Increases Expression [7]
HAUS augmin-like complex subunit 6 (HAUS6) OT7ZVR57 HAUS6_HUMAN Increases Expression [7]
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (PIP4P1) OT991XS0 PP4P1_HUMAN Decreases Expression [7]
Kinectin (KTN1) OTQAV541 KTN1_HUMAN Increases Expression [7]
Phosphatidylcholine:ceramide cholinephosphotransferase 1 (SGMS1) OTZQE7PW SMS1_HUMAN Increases Expression [7]
Sodium-independent sulfate anion transporter (SLC26A11) OTWBV9CR S2611_HUMAN Increases Expression [7]
RNA-binding protein MEX3D (MEX3D) OTAUWRK7 MEX3D_HUMAN Decreases Expression [7]
Dynein axonemal assembly factor 5 (DNAAF5) OTN0CT52 DAAF5_HUMAN Decreases Expression [7]
Syntaxin-12 (STX12) OT5IBQ62 STX12_HUMAN Increases Expression [7]
Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3) OTNJX38T M4K3_HUMAN Increases Expression [7]
Protein FAM219A (FAM219A) OTAFZHY9 F219A_HUMAN Increases Expression [7]
Mitofusin-1 (MFN1) OTCBXQZF MFN1_HUMAN Decreases Expression [7]
Pleckstrin homology domain-containing family M member 2 (PLEKHM2) OT4ZYV73 PKHM2_HUMAN Decreases Expression [7]
Mitochondrial Rho GTPase 2 (RHOT2) OTV8WT2L MIRO2_HUMAN Decreases Expression [7]
Xaa-Arg dipeptidase (PM20D2) OTD2Y7LU P20D2_HUMAN Increases Expression [7]
Solute carrier family 38 member 6 (SLC38A6) OTIC8SHQ S38A6_HUMAN Increases Expression [7]
Abl interactor 1 (ABI1) OT5H4M62 ABI1_HUMAN Increases Expression [7]
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2) OTRUIMC4 GNT2A_HUMAN Increases Expression [7]
Protein FAM43A (FAM43A) OT5RPQRE FA43A_HUMAN Decreases Expression [7]
CAP-Gly domain-containing linker protein 4 (CLIP4) OT75KVQK CLIP4_HUMAN Increases Expression [7]
Putative transporter SVOPL (SVOPL) OTJ4G2ND SVOPL_HUMAN Decreases Expression [7]
Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) OT6WKC13 GALT4_HUMAN Increases Expression [7]
Coiled-coil domain-containing protein 82 (CCDC82) OT16EAZ7 CCD82_HUMAN Increases Expression [7]
SH2 domain-containing protein 3C (SH2D3C) OTAGXO0N SH2D3_HUMAN Decreases Expression [7]
Methyltransferase-like protein 27 (METTL27) OTOF0GTU MET27_HUMAN Decreases Expression [7]
ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1) OTM3KHIE ARFG1_HUMAN Decreases Expression [7]
Protein KRI1 homolog (KRI1) OT1IGOK7 KRI1_HUMAN Increases Expression [7]
ATPase family gene 2 protein homolog A (AFG2A) OTPZKWN7 AFG2A_HUMAN Increases Expression [7]
Equilibrative nucleobase transporter 1 (SLC43A3) OTR60ZLA S43A3_HUMAN Decreases Expression [7]
Retinol dehydrogenase 13 (RDH13) OT48VJ65 RDH13_HUMAN Increases Expression [7]
Neuropilin and tolloid-like protein 2 (NETO2) OT0YAMC0 NETO2_HUMAN Decreases Expression [7]
Polyhomeotic-like protein 3 (PHC3) OTTTLIAP PHC3_HUMAN Increases Expression [7]
Glutathione S-transferase C-terminal domain-containing protein (GSTCD) OTIIINMT GSTCD_HUMAN Decreases Expression [7]
Folliculin (FLCN) OTVM78XM FLCN_HUMAN Increases Expression [7]
Tubulin--tyrosine ligase (TTL) OTSS1CK4 TTL_HUMAN Decreases Expression [7]
Protein NEDD1 (NEDD1) OTBD6X77 NEDD1_HUMAN Increases Expression [7]
Protein FAM76A (FAM76A) OT28WHO4 FA76A_HUMAN Increases Expression [7]
Proline-rich protein 7 (PRR7) OT56XAQK PRR7_HUMAN Decreases Expression [7]
Transmembrane protein 254 (TMEM254) OTGDPU8S TM254_HUMAN Decreases Expression [7]
Retinol dehydrogenase 11 (RDH11) OTIND43N RDH11_HUMAN Increases Expression [7]
POC1 centriolar protein homolog B (POC1B) OTDIMIRZ POC1B_HUMAN Increases Expression [7]
Interferon-induced protein 44 (IFI44) OTOKSZVA IFI44_HUMAN Increases Expression [7]
Large ribosomal subunit protein uL30m (MRPL30) OT26OPYV RM30_HUMAN Decreases Expression [7]
RB1-inducible coiled-coil protein 1 (RB1CC1) OTZK8PFX RBCC1_HUMAN Increases Expression [7]
Elongator complex protein 5 (ELP5) OTW5R7YD ELP5_HUMAN Decreases Expression [7]
DDB1- and CUL4-associated factor 11 (DCAF11) OTNSGYK1 DCA11_HUMAN Decreases Expression [7]
Arginine/serine-rich protein PNISR (PNISR) OTUM02FW PNISR_HUMAN Increases Expression [7]
General transcription factor 3C polypeptide 2 (GTF3C2) OTWDANLJ TF3C2_HUMAN Decreases Expression [7]
Transmembrane protein 263 (TMEM263) OTO1RSTS TM263_HUMAN Increases Expression [7]
Protein THEM6 (THEM6) OT51SVLH THEM6_HUMAN Decreases Expression [7]
Pleckstrin homology-like domain family A member 1 (PHLDA1) OTFTWMIQ PHLA1_HUMAN Increases Expression [7]
Hexosaminidase D (HEXD) OTTMQKLM HEXD_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase RNF138 (RNF138) OTPU0CO4 RN138_HUMAN Increases Expression [7]
Heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL) OTA6Q5E0 HNRLL_HUMAN Increases Expression [7]
Uncharacterized protein C4orf3 (C4ORF3) OT6TFN1O CD003_HUMAN Decreases Expression [7]
tRNA-splicing endonuclease subunit Sen15 (TSEN15) OT14UW31 SEN15_HUMAN Decreases Expression [7]
Palladin (PALLD) OTZ2MUJZ PALLD_HUMAN Increases Expression [7]
Protein N-lysine methyltransferase METTL21A (METTL21A) OTXJTNXY MT21A_HUMAN Increases Expression [7]
Histone acetyltransferase KAT6B (KAT6B) OTMUDTAH KAT6B_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase rififylin (RFFL) OT85MGDH RFFL_HUMAN Increases Expression [7]
Aquaporin-3 (AQP3) OT2J7JPD AQP3_HUMAN Increases Expression [7]
Proteasome inhibitor PI31 subunit (PSMF1) OTX84WLQ PSMF1_HUMAN Decreases Expression [7]
Protein FAM168A (FAM168A) OTDXQCS5 F168A_HUMAN Increases Expression [7]
Protein NDRG1 (NDRG1) OTVO66BO NDRG1_HUMAN Increases Expression [7]
TRAF family member-associated NF-kappa-B activator (TANK) OTZSGFIK TANK_HUMAN Increases Expression [7]
Ras-related protein Rab-8B (RAB8B) OTBPUHV9 RAB8B_HUMAN Decreases Expression [7]
GTP-binding protein Rit1 (RIT1) OTVNOGOH RIT1_HUMAN Increases Expression [7]
Phosphorylase b kinase regulatory subunit beta (PHKB) OTKXZZIU KPBB_HUMAN Increases Expression [7]
BLOC-2 complex member HPS3 (HPS3) OTAKROK7 HPS3_HUMAN Decreases Expression [7]
F-box/WD repeat-containing protein 7 (FBXW7) OTJXE4OT FBXW7_HUMAN Decreases Expression [7]
Polyamine deacetylase HDAC10 (HDAC10) OTHCKKUQ HDA10_HUMAN Decreases Expression [7]
NXPE family member 3 (NXPE3) OTLVZ8W2 NXPE3_HUMAN Increases Expression [7]
Transmembrane protein 230 (TMEM230) OTAFALFV TM230_HUMAN Decreases Expression [7]
SOSS complex subunit B2 (NABP1) OTFTNFHW SOSB2_HUMAN Increases Expression [7]
Ankyrin repeat domain-containing protein 9 (ANKRD9) OT7VGO6G ANKR9_HUMAN Increases Expression [7]
ADP-ribosylation factor-like protein 8A (ARL8A) OTEYM6FA ARL8A_HUMAN Increases Expression [7]
m7GpppX diphosphatase (DCPS) OT1FZVC9 DCPS_HUMAN Decreases Expression [7]
Protein FAM241B (FAM241B) OTLISLRC F241B_HUMAN Increases Expression [7]
R3H domain-containing protein 4 (R3HDM4) OTE0Q78Q R3HD4_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase CHFR (CHFR) OTRAD2TT CHFR_HUMAN Decreases Expression [7]
ATP-dependent DNA helicase DDX11 (DDX11) OT1WR3MD DDX11_HUMAN Decreases Expression [7]
Kelch domain-containing protein 7B (KLHDC7B) OT2H5BNX KLD7B_HUMAN Increases Expression [7]
H/ACA ribonucleoprotein complex non-core subunit NAF1 (NAF1) OTMJKJAK NAF1_HUMAN Increases Expression [7]
Histone-lysine N-methyltransferase EHMT2 (EHMT2) OTC4DWB6 EHMT2_HUMAN Decreases Expression [7]
Uncharacterized protein C9orf85 (C9ORF85) OTJWBPL3 CI085_HUMAN Increases Expression [7]
Pannexin-2 (PANX2) OTAQ2S8R PANX2_HUMAN Increases Expression [7]
Ribosomal protein S6 kinase delta-1 (RPS6KC1) OT2LRTG4 KS6C1_HUMAN Increases Expression [7]
Structural maintenance of chromosomes protein 6 (SMC6) OT3IBHQD SMC6_HUMAN Increases Expression [7]
Protein orai-2 (ORAI2) OTYISRYH ORAI2_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase RING2 (RNF2) OTFPLOIN RING2_HUMAN Increases Expression [7]
Krueppel-like factor 6 (KLF6) OTQY9S7F KLF6_HUMAN Increases Expression [7]
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (SDHC) OTC8G2MX C560_HUMAN Decreases Expression [7]
Sigma non-opioid intracellular receptor 1 (SIGMAR1) OTDORW5C SGMR1_HUMAN Decreases Expression [7]
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A) OTVTB5R5 PI51A_HUMAN Decreases Expression [7]
Apolipoprotein L4 (APOL4) OTTOH86V APOL4_HUMAN Decreases Expression [7]
Protein NipSnap homolog 1 (NIPSNAP1) OTKXKUT8 NIPS1_HUMAN Decreases Expression [7]
Protein FAM118B (FAM118B) OTRLY4B0 F118B_HUMAN Increases Expression [7]
Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1) OTYKB9G3 SIN1_HUMAN Decreases Expression [7]
TM2 domain-containing protein 3 (TM2D3) OT6MS96W TM2D3_HUMAN Increases Expression [7]
Ferroptosis suppressor protein 1 (AIFM2) OT57XWXO FSP1_HUMAN Increases Expression [7]
Tubulin-specific chaperone D (TBCD) OTS4JKNQ TBCD_HUMAN Decreases Expression [7]
Iron-sulfur cluster assembly 1 homolog, mitochondrial (ISCA1) OTU230MC ISCA1_HUMAN Increases Expression [7]
Bublin coiled-coil protein (BBLN) OTUMVEWE BBLN_HUMAN Decreases Expression [7]
Coiled-coil domain-containing protein 32 (CCDC32) OTPPUFIF CCD32_HUMAN Increases Expression [7]
Kinesin-like protein KIFC1 (KIFC1) OTNQDS00 KIFC1_HUMAN Decreases Expression [7]
Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1) OTBUZ7KA KATL1_HUMAN Increases Expression [7]
Protein C1orf43 (C1ORF43) OTT9CVZR CA043_HUMAN Decreases Expression [7]
TM2 domain-containing protein 2 (TM2D2) OTB51WEY TM2D2_HUMAN Increases Expression [7]
Sphingosine-1-phosphate phosphatase 1 (SGPP1) OT9X54CQ SGPP1_HUMAN Increases Expression [7]
FSD1-like protein (FSD1L) OTBQ48RF FSD1L_HUMAN Increases Expression [7]
C-type lectin domain family 7 member A (CLEC7A) OTRTBH27 CLC7A_HUMAN Increases Expression [7]
Serrate RNA effector molecule homolog (SRRT) OTMYPSWV SRRT_HUMAN Decreases Expression [7]
Protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1) OT07Z2RQ PACN1_HUMAN Increases Expression [7]
Sterile alpha motif domain-containing protein 10 (SAMD10) OTBKWB5C SAM10_HUMAN Decreases Expression [7]
ATP-binding cassette sub-family A member 2 (ABCA2) OTVSYK0X ABCA2_HUMAN Decreases Expression [7]
INO80 complex subunit B (INO80B) OTSHV8JF IN80B_HUMAN Decreases Expression [7]
Uncharacterized protein C6orf62 (C6ORF62) OTGK4G35 CF062_HUMAN Increases Expression [7]
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) OT4U7SBG GBRL1_HUMAN Increases Expression [7]
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1) OTL4VJC5 NUCKS_HUMAN Decreases Expression [7]
Oxysterol-binding protein-related protein 2 (OSBPL2) OTCK671N OSBL2_HUMAN Increases Expression [7]
Dual specificity protein phosphatase 15 (DUSP15) OTS6PQYL DUS15_HUMAN Decreases Expression [7]
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (KCTD10) OT5HFZXU BACD3_HUMAN Increases Expression [7]
UPF0696 protein C11orf68 (C11ORF68) OTOKOGZ6 CK068_HUMAN Decreases Expression [7]
Differentially expressed in FDCP 6 homolog (DEF6) OTIRBYVK DEFI6_HUMAN Decreases Expression [7]
Sentrin-specific protease 3 (SENP3) OTFQDOMC SENP3_HUMAN Decreases Expression [7]
ESF1 homolog (ESF1) OTHEDM0A ESF1_HUMAN Increases Expression [7]
RNA polymerase II-associated protein 3 (RPAP3) OTCW17LF RPAP3_HUMAN Increases Expression [7]
Sin3 histone deacetylase corepressor complex component SDS3 (SUDS3) OTZ1AARI SDS3_HUMAN Increases Expression [7]
Caspase activity and apoptosis inhibitor 1 (CAAP1) OTD2DN1Z CAAP1_HUMAN Increases Expression [7]
Kinesin-like protein KIF9 (KIF9) OT7W6VI1 KIF9_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase SMURF2 (SMURF2) OT3TRVL7 SMUF2_HUMAN Increases Expression [7]
Transcription factor IIIB 50 kDa subunit (BRF2) OT2C6TH2 BRF2_HUMAN Increases Expression [7]
Retinoid-inducible serine carboxypeptidase (SCPEP1) OT43LYEZ RISC_HUMAN Increases Expression [7]
POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1) OT0X9WGR PATZ1_HUMAN Decreases Expression [7]
DNA dC->dU-editing enzyme APOBEC-3G (APOBEC3G) OT410VP5 ABC3G_HUMAN Increases Expression [7]
DnaJ homolog subfamily C member 4 (DNAJC4) OT4BUBQU DNJC4_HUMAN Decreases Expression [7]
DNA-directed DNA/RNA polymerase mu (POLM) OT0SRIP4 DPOLM_HUMAN Decreases Expression [7]
Carbohydrate sulfotransferase 11 (CHST11) OTNJJ5Q1 CHSTB_HUMAN Decreases Expression [7]
Uncharacterized protein C14orf132 (C14ORF132) OTBVC3AO CN132_HUMAN Decreases Expression [7]
Putative RNA-binding protein Luc7-like 1 (LUC7L) OT77JDB7 LUC7L_HUMAN Increases Expression [7]
Prefoldin subunit 4 (PFDN4) OT5NRHER PFD4_HUMAN Increases Expression [7]
Solute carrier family 35 member C2 (SLC35C2) OT9H15XZ S35C2_HUMAN Decreases Expression [7]
Gephyrin (GPHN) OTAKK1SV GEPH_HUMAN Decreases Expression [7]
Endophilin-B2 (SH3GLB2) OTF7BB9S SHLB2_HUMAN Decreases Expression [7]
Muscleblind-like protein 1 (MBNL1) OTOV7J85 MBNL1_HUMAN Decreases Expression [7]
CDC42 small effector protein 2 (CDC42SE2) OT8SG9I1 C42S2_HUMAN Decreases Expression [7]
RNA-binding protein PNO1 (PNO1) OT010GIS PNO1_HUMAN Increases Expression [7]
DDB1- and CUL4-associated factor 13 (DCAF13) OTQQ0QXT DCA13_HUMAN Increases Expression [7]
FGFR1 oncogene partner 2 (FGFR1OP2) OTAHO1ZC FGOP2_HUMAN Increases Expression [7]
DNA-directed RNA polymerase III subunit RPC5 (POLR3E) OT69PWBM RPC5_HUMAN Increases Expression [7]
Anoctamin-10 (ANO10) OTG3BNOU ANO10_HUMAN Increases Expression [7]
BSD domain-containing protein 1 (BSDC1) OT853CP9 BSDC1_HUMAN Increases Expression [7]
G patch domain-containing protein 2-like (GPATCH2L) OTETUZ64 GPT2L_HUMAN Increases Expression [7]
Ceroid-lipofuscinosis neuronal protein 6 (CLN6) OT91IAYT CLN6_HUMAN Decreases Expression [7]
AFG2-interacting ribosome maturation factor (AIRIM) OTGG814L AIRIM_HUMAN Increases Expression [7]
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2) OTE69HV8 B3GN2_HUMAN Decreases Expression [7]
Opioid growth factor receptor (OGFR) OTROS6RJ OGFR_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase KCMF1 (KCMF1) OTVTKFAU KCMF1_HUMAN Increases Expression [7]
Stromal interaction molecule 2 (STIM2) OTYNXAW0 STIM2_HUMAN Decreases Expression [7]
Inhibitor of Bruton tyrosine kinase (IBTK) OTB2GM4G IBTK_HUMAN Increases Expression [7]
Phosphatidylinositol 4-kinase beta (PI4KB) OTI9UQSU PI4KB_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase RNF14 (RNF14) OTWX0D0H RNF14_HUMAN Increases Expression [7]
Fibulin-5 (FBLN5) OTLVNZ8U FBLN5_HUMAN Decreases Expression [7]
Beta-1,4-galactosyltransferase 6 (B4GALT6) OTBM8F2U B4GT6_HUMAN Increases Expression [7]
LIM domain-containing protein 1 (LIMD1) OTN1CG6R LIMD1_HUMAN Increases Expression [7]
Protein NDRG3 (NDRG3) OTJTJCHD NDRG3_HUMAN Decreases Expression [7]
LIM domain and actin-binding protein 1 (LIMA1) OTONPC9R LIMA1_HUMAN Increases Expression [7]
AF4/FMR2 family member 4 (AFF4) OTTL5Y8R AFF4_HUMAN Increases Expression [7]
NADH-cytochrome b5 reductase 1 (CYB5R1) OTMDHMLA NB5R1_HUMAN Increases Expression [7]
Methyl-CpG-binding domain protein 1 (MBD1) OTD19VO6 MBD1_HUMAN Decreases Expression [7]
Oxidative stress-induced growth inhibitor 1 (OSGIN1) OT9KIVZW OSGI1_HUMAN Increases Expression [7]
Cell division cycle protein 23 homolog (CDC23) OTC4O83E CDC23_HUMAN Increases Expression [7]
Anaphase-promoting complex subunit 5 (ANAPC5) OTGTJNNR APC5_HUMAN Decreases Expression [7]
Calcipressin-3 (RCAN3) OTTS3CQA RCAN3_HUMAN Decreases Expression [7]
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (ASAP1) OT4DLRYY ASAP1_HUMAN Decreases Expression [7]
Tetratricopeptide repeat protein 7A (TTC7A) OTDHLPQM TTC7A_HUMAN Decreases Expression [7]
Nucleosome assembly protein 1-like 2 (NAP1L2) OT8QI4GF NP1L2_HUMAN Increases Expression [7]
Protein PHTF1 (PHTF1) OTYCZ84A PHTF1_HUMAN Increases Expression [7]
26S proteasome non-ATPase regulatory subunit 13 (PSMD13) OTNQ351N PSD13_HUMAN Increases Expression [7]
Cytosolic carboxypeptidase 1 (AGTPBP1) OTR92JFR CBPC1_HUMAN Increases Expression [7]
Serine/threonine-protein kinase ICK (CILK1) OTWOYEYP CILK1_HUMAN Increases Expression [7]
Structural maintenance of chromosomes protein 3 (SMC3) OTWGFRHD SMC3_HUMAN Increases Expression [7]
Myotubularin-related protein 6 (MTMR6) OTQPAWI3 MTMR6_HUMAN Increases Expression [7]
Phospholipase A-2-activating protein (PLAA) OTZ7NJGA PLAP_HUMAN Increases Expression [7]
Phenylalanine--tRNA ligase alpha subunit (FARSA) OT3U1P20 SYFA_HUMAN Decreases Expression [7]
Nck-associated protein 1 (NCKAP1) OTEZQXXJ NCKP1_HUMAN Increases Expression [7]
Kelch-like protein 20 (KLHL20) OTC0SFS9 KLH20_HUMAN Increases Expression [7]
ARF GTPase-activating protein GIT1 (GIT1) OTHO92S5 GIT1_HUMAN Decreases Expression [7]
RING finger protein 11 (RNF11) OTFBJSKQ RNF11_HUMAN Increases Expression [7]
Transformation/transcription domain-associated protein (TRRAP) OT68OI2Y TRRAP_HUMAN Decreases Expression [7]
Carbohydrate sulfotransferase 2 (CHST2) OTV11IZF CHST2_HUMAN Decreases Expression [7]
G-protein-signaling modulator 3 (GPSM3) OT2MO458 GPSM3_HUMAN Decreases Expression [7]
U6 snRNA-associated Sm-like protein LSm4 (LSM4) OTLKJB3A LSM4_HUMAN Decreases Expression [7]
DNA-directed RNA polymerase III subunit RPC8 (POLR3H) OT7GM7MX RPC8_HUMAN Decreases Expression [7]
NEDD8 ultimate buster 1 (NUB1) OTWA6RTX NUB1_HUMAN Increases Expression [7]
Selenoprotein K (SELENOK) OTKM7N7P SELK_HUMAN Increases Expression [7]
Nuclear receptor coactivator 3 (NCOA3) OTBX300Z NCOA3_HUMAN Increases Expression [7]
Numb-like protein (NUMBL) OTWMTMMH NUMBL_HUMAN Increases Expression [7]
ATPase MORC2 (MORC2) OT52A8BJ MORC2_HUMAN Increases Expression [7]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Increases Expression [21]
Aldo-keto reductase family 1 member B1 (AKR1B1) OTRX72TH ALDR_HUMAN Increases Expression [21]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Increases Expression [21]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Increases Expression [21]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Affects Expression [21]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Increases Expression [21]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Increases Expression [21]
Toll-like receptor 4 (TLR4) OTP7ML3S TLR4_HUMAN Increases Expression [22]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) OTBPCU2O TR10A_HUMAN Decreases Expression [23]
NF-kappa-B inhibitor epsilon (NFKBIE) OTLAYEL9 IKBE_HUMAN Increases Stability [24]
Myc box-dependent-interacting protein 1 (BIN1) OTK8O0X8 BIN1_HUMAN Increases Expression [12]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [25]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Decreases Expression [10]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) OTLF4ZB1 IKKA_HUMAN Increases Expression [10]
Apoptosis regulatory protein Siva (SIVA1) OTDT0XZK SIVA_HUMAN Decreases Expression [12]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [26]
High affinity copper uptake protein 1 (SLC31A1) OTXLRTUB COPT1_HUMAN Decreases Degradation [27]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [12]
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) OTDTF5BU SUV91_HUMAN Decreases Expression [12]
Serine protease HTRA2, mitochondrial (HTRA2) OTC7616F HTRA2_HUMAN Affects Localization [28]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Activity [29]
Nuclear protein 1 (NUPR1) OT4FU8C0 NUPR1_HUMAN Increases Expression [30]
Toll-like receptor 2 (TLR2) OTGO5P4R TLR2_HUMAN Increases Expression [10]
DENN domain-containing protein 4B (DENND4B) OTFEO8KG DEN4B_HUMAN Increases Expression [31]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B) OTL9I7LO GA45B_HUMAN Increases Expression [31]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [31]
Natural cytotoxicity triggering receptor 1 (NCR1) OT6MZKQY NCTR1_HUMAN Decreases Expression [32]
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G) OT8V1J4M GA45G_HUMAN Increases Expression [26]
BAG family molecular chaperone regulator 3 (BAG3) OTVXYUDQ BAG3_HUMAN Increases Expression [31]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Affects Localization [28]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [33]
Insulin-like growth factor II (IGF2) OTJ4O6MW IGF2_HUMAN Decreases Response To Substance [34]
Prelamin-A/C (LMNA) OT3SG7ZR LMNA_HUMAN Increases Cleavage [35]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Decreases Expression [36]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Phosphorylation [37]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Activity [38]
Galectin-2 (LGALS2) OTY08TMQ LEG2_HUMAN Decreases Expression [12]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Increases Phosphorylation [39]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Expression [40]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Decreases Expression [10]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Decreases Expression [10]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Activity [8]
Integrin alpha-V (ITGAV) OTAM7JTR ITAV_HUMAN Increases Expression [10]
Cathepsin B (CTSB) OTP9G5QB CATB_HUMAN Increases Localization [29]
Heat shock protein HSP 90-alpha (HSP90AA1) OTLG1WPK HS90A_HUMAN Decreases Expression [10]
Heat shock protein HSP 90-beta (HSP90AB1) OTR69EG7 HS90B_HUMAN Increases Expression [22]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Increases Expression [31]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [31]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [41]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Increases Expression [22]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [31]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Decreases Expression [42]
Cytochrome c oxidase subunit 8A, mitochondrial (COX8A) OTU0NR39 COX8A_HUMAN Decreases Expression [38]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [43]
Osteopontin (SPP1) OTJGC23Y OSTP_HUMAN Decreases Expression [10]
Growth hormone receptor (GHR) OT8WUWMU GHR_HUMAN Increases Expression [22]
Parathyroid hormone-related protein (PTHLH) OTI1JF13 PTHR_HUMAN Decreases Expression [42]
Interferon-induced transmembrane protein 1 (IFITM1) OTECO1G8 IFM1_HUMAN Decreases Expression [12]
Protein Cripto (CRIPTO) OT46DZXJ TDGF1_HUMAN Increases Expression [22]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Decreases Expression [10]
Tissue factor (F3) OT3MSU3B TF_HUMAN Increases Expression [44]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Increases Expression [45]
Interleukin-1 receptor type 1 (IL1R1) OTTU8959 IL1R1_HUMAN Increases Expression [22]
Transcription factor 4 (TCF4) OTB9ASTK ITF2_HUMAN Increases Expression [22]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Decreases Phosphorylation [46]
Interleukin-7 receptor subunit alpha (IL7R) OTBMFLQQ IL7RA_HUMAN Increases Expression [10]
Heat shock 70 kDa protein 6 (HSPA6) OTH4S7WB HSP76_HUMAN Increases Expression [31]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Decreases Expression [47]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Decreases Expression [10]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Increases Expression [10]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [26]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Increases Expression [31]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Expression [48]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Affects Expression [23]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Activity [8]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Decreases Expression [10]
DnaJ homolog subfamily B member 1 (DNAJB1) OTCOSEVH DNJB1_HUMAN Increases Expression [31]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Increases Expression [22]
Pentraxin-related protein PTX3 (PTX3) OTPXHRKU PTX3_HUMAN Decreases Expression [10]
CD27 antigen (CD27) OTH7NA58 CD27_HUMAN Increases Expression [22]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Activity [36]
Calreticulin (CALR) OTYD2TR1 CALR_HUMAN Increases Expression [20]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Activity [36]
Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) OT33XNZM PTN6_HUMAN Decreases Expression [12]
SHC-transforming protein 1 (SHC1) OT1J5IRN SHC1_HUMAN Decreases Expression [10]
Nitric oxide synthase 1 (NOS1) OT7M8XVG NOS1_HUMAN Increases Expression [20]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Activity [36]
DNA replication licensing factor MCM7 (MCM7) OT6FXC6K MCM7_HUMAN Decreases Expression [12]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Increases Expression [49]
Replication protein A 14 kDa subunit (RPA3) OT8JAQGL RFA3_HUMAN Decreases Expression [12]
Pro-adrenomedullin (ADM) OT7T0TA4 ADML_HUMAN Decreases Expression [10]
Insulin receptor substrate 1 (IRS1) OTNO82CU IRS1_HUMAN Decreases Degradation [50]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [12]
Alpha-synuclein (SNCA) OTPWC1MR SYUA_HUMAN Increases Expression [22]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [51]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [26]
Small ribosomal subunit protein eS19 (RPS19) OTBKGP48 RS19_HUMAN Increases Expression [31]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [39]
Caspase-2 (CASP2) OTUDYSPP CASP2_HUMAN Increases Cleavage [31]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Increases Phosphorylation [52]
Mitogen-activated protein kinase 9 (MAPK9) OTCEVJ9E MK09_HUMAN Increases Phosphorylation [52]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [53]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [8]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Increases Expression [54]
Caspase-4 (CASP4) OTVQTV1L CASP4_HUMAN Increases Activity [39]
Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A) OT5QQB5L IDH3A_HUMAN Decreases Expression [38]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Decreases Expression [55]
Small ribosomal subunit protein mS29 (DAP3) OTNPEZYM RT29_HUMAN Increases Expression [12]
Breast cancer type 2 susceptibility protein (BRCA2) OTF1XSV1 BRCA2_HUMAN Decreases Expression [51]
Interleukin-1 receptor-associated kinase 1 (IRAK1) OT133G8J IRAK1_HUMAN Decreases Expression [10]
DNA mismatch repair protein Msh6 (MSH6) OT46FP09 MSH6_HUMAN Decreases Expression [12]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Activity [56]
Caspase-6 (CASP6) OTXLD3EC CASP6_HUMAN Increases Cleavage [41]
Hepatocyte nuclear factor 3-alpha (FOXA1) OTEBY0TD FOXA1_HUMAN Decreases Expression [10]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Increases Cleavage [26]
Histone deacetylase 4 (HDAC4) OTQNGD32 HDAC4_HUMAN Decreases Expression [12]
NACHT, LRR and PYD domains-containing protein 12 (NLRP12) OTGR132Z NAL12_HUMAN Increases Expression [10]
Beta-2-microglobulin (B2M) OTDWN6NX B2MG_HUMAN Decreases Expression [57]
C-C motif chemokine 8 (CCL8) OTCTWYN8 CCL8_HUMAN Affects Expression [23]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Affects Localization [28]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Increases Expression [22]
Nuclear factor NF-kappa-B p100 subunit (NFKB2) OTS231V7 NFKB2_HUMAN Decreases Expression [48]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Cleavage [58]
Dystonin (DST) OTHZBM4X DYST_HUMAN Increases Expression [12]
Heat shock factor protein 2 (HSF2) OTXNJIJ9 HSF2_HUMAN Increases Expression [59]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Decreases Expression [51]
Fragile X messenger ribonucleoprotein 1 (FMR1) OTWEV0T5 FMR1_HUMAN Decreases Expression [12]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [60]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [29]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Increases Cleavage [41]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Increases Expression [35]
Baculoviral IAP repeat-containing protein 1 (NAIP) OTLA925F BIRC1_HUMAN Affects Expression [48]
Chromatin assembly factor 1 subunit A (CHAF1A) OTXSSY4H CAF1A_HUMAN Decreases Expression [12]
S-phase kinase-associated protein 2 (SKP2) OTD5B41X SKP2_HUMAN Decreases Expression [61]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Increases Cleavage [58]
Bcl-2-interacting killer (BIK) OTTH1T3D BIK_HUMAN Increases Activity [29]
Interleukin-18 receptor 1 (IL18R1) OT83XMPQ IL18R_HUMAN Increases Expression [22]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Increases Expression [62]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Decreases Expression [24]
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) OTC41R1E RIPK1_HUMAN Decreases Expression [10]
Cullin-1 (CUL1) OTXPE1UZ CUL1_HUMAN Increases Expression [22]
Cullin-3 (CUL3) OTDNOAPM CUL3_HUMAN Decreases Expression [12]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Decreases Expression [48]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Cleavage [58]
Transcription elongation factor A protein-like 1 (TCEAL1) OTAPG2L5 TCAL1_HUMAN Increases Expression [22]
Interferon regulatory factor 4 (IRF4) OT1DHQ1P IRF4_HUMAN Decreases Expression [47]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Increases Activity [38]
Hsp90 co-chaperone Cdc37 (CDC37) OTYDT4A7 CDC37_HUMAN Increases Expression [22]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Expression [63]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Increases Expression [64]
Carbonic anhydrase 9 (CA9) OTNA51XT CAH9_HUMAN Decreases Expression [64]
TIR domain-containing adapter molecule 2 (TICAM2) OTK7GIJ5 TCAM2_HUMAN Increases Expression [10]
Cell division cycle and apoptosis regulator protein 1 (CCAR1) OTUXLQZZ CCAR1_HUMAN Increases Expression [65]
Ectodysplasin-A receptor-associated adapter protein (EDARADD) OT0G52MC EDAD_HUMAN Increases Expression [22]
DNA-binding death effector domain-containing protein 2 (DEDD2) OT0WXRWT DEDD2_HUMAN Increases Expression [12]
Heat shock protein 105 kDa (HSPH1) OTVRR73T HS105_HUMAN Increases Expression [26]
CREB-binding protein (CREBBP) OTPA4QGM CBP_HUMAN Decreases Expression [48]
Histone acetyltransferase KAT2B (KAT2B) OTWQITWK KAT2B_HUMAN Decreases Expression [10]
Bcl-2-like protein 2 (BCL2L2) OTMKVO0J B2CL2_HUMAN Increases Expression [66]
N-alpha-acetyltransferase 80 (NAA80) OTLWR71Z NAA80_HUMAN Decreases Expression [12]
MOB kinase activator 3A (MOB3A) OTILIOXF MOB3A_HUMAN Decreases Expression [12]
Baculoviral IAP repeat-containing protein 7 (BIRC7) OTITCGHB BIRC7_HUMAN Decreases Expression [67]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3) OTZM6MHU NLRP3_HUMAN Decreases Expression [12]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [68]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Increases Expression [20]
Cell growth regulator with EF hand domain protein 1 (CGREF1) OTBZQX97 CGRE1_HUMAN Increases Expression [22]
Myeloid differentiation primary response protein MyD88 (MYD88) OTB4D6FL MYD88_HUMAN Decreases Expression [10]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) OTJGE772 CHAC1_HUMAN Increases Expression [31]
Fanconi anemia group D2 protein (FANCD2) OTVEB5LF FACD2_HUMAN Decreases Expression [69]
Eukaryotic translation initiation factor 2A (EIF2A) OTWXELQP EIF2A_HUMAN Decreases Phosphorylation [70]
DNA replication factor Cdt1 (CDT1) OTVY53VG CDT1_HUMAN Decreases Expression [12]
Interleukin-23 subunit alpha (IL23A) OTYO99HC IL23A_HUMAN Increases Expression [22]
Transcription factor 7-like 2 (TCF7L2) OTVWPZ8B TF7L2_HUMAN Increases Expression [22]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Increases Expression [48]
Sphingosine kinase 1 (SPHK1) OTWYPBVD SPHK1_HUMAN Decreases Expression [71]
Anaphase-promoting complex subunit 11 (ANAPC11) OTK2SJXR APC11_HUMAN Decreases Expression [12]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) OT0DZGY4 E2AK3_HUMAN Increases Phosphorylation [31]
Lipid transferase CIDEB (CIDEB) OT873IYM CIDEB_HUMAN Decreases Expression [12]
Adenine DNA glycosylase (MUTYH) OTXTKI7Q MUTYH_HUMAN Decreases Expression [12]
Cell cycle progression protein 1 (CCPG1) OT0IHDKL CCPG1_HUMAN Increases Expression [10]
FAS-associated factor 1 (FAF1) OTGAMLM4 FAF1_HUMAN Increases Expression [22]
Transcription factor 19 (TCF19) OT7NKLF9 TCF19_HUMAN Decreases Expression [12]
Cyclic AMP-dependent transcription factor ATF-5 (ATF5) OT03QCLM ATF5_HUMAN Increases Expression [26]
Rho-related BTB domain-containing protein 2 (RHOBTB2) OT2DATFX RHBT2_HUMAN Increases Response To Substance [72]
Beclin-1 (BECN1) OT4X293M BECN1_HUMAN Decreases Response To Substance [73]
Palmitoyl thioesterase CPT1C (CPT1C) OT8F1MBF CPT1C_HUMAN Increases Response To Substance [72]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1) OT959A3A AT2A1_HUMAN Affects Response To Substance [74]
Histone deacetylase 6 (HDAC6) OT9W9MXQ HDAC6_HUMAN Decreases Response To Substance [75]
Serine/threonine-protein kinase 4 (STK4) OTBRYNNH STK4_HUMAN Increases Response To Substance [76]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Response To Substance [72]
Transcription factor SOX-8 (SOX8) OTEJXYZM SOX8_HUMAN Increases Response To Substance [72]
DNA repair endonuclease XPF (ERCC4) OTFIOPG1 XPF_HUMAN Increases Response To Substance [72]
Polyunsaturated fatty acid lipoxygenase ALOX12 (ALOX12) OTFL5KR5 LOX12_HUMAN Increases Response To Substance [72]
Heat shock protein beta-1 (HSPB1) OTHFZ8ED HSPB1_HUMAN Decreases Response To Substance [77]
Peroxisome proliferator-activated receptor delta (PPARD) OTI4WTOP PPARD_HUMAN Increases Response To Substance [72]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Increases Response To Substance [72]
Unconventional myosin-Va (MYO5A) OTMWLP3E MYO5A_HUMAN Increases Response To Substance [72]
Proteasome subunit beta type-5 (PSMB5) OTOZXAS6 PSB5_HUMAN Decreases Response To Substance [78]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Increases Response To Substance [79]
Mannose-binding protein C (MBL2) OTS63HG5 MBL2_HUMAN Increases Response To Substance [72]
Nucleophosmin (NPM1) OTTBYYT0 NPM_HUMAN Increases Response To Substance [80]
BRCA1-associated RING domain protein 1 (BARD1) OTTC0Z9Y BARD1_HUMAN Increases Response To Substance [79]
General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) OTVAW3P1 ERCC3_HUMAN Increases Response To Substance [72]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Increases Response To Substance [72]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1) OTY9R6FZ ERN1_HUMAN Decreases Response To Substance [39]
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⏷ Show the Full List of 686 DOT(s)
Indication(s) of Irinotecan
Disease Entry ICD 11 Status REF
Adenocarcinoma 2D40 Approved [5]
Advanced cancer 2A00-2F9Z Approved [5]
Appendiceal neoplasm N.A. Approved [5]
Astrocytoma 2A00.0Y Approved [5]
Brain glioma N.A. Approved [5]
Colon adenocarcinoma N.A. Approved [5]
Colorectal cancer 2B91.Z Approved [6]
Endocrine gland neoplasm N.A. Approved [5]
Kidney neoplasm N.A. Approved [5]
Metastasis from malignant tumor of colon N.A. Approved [5]
Peritoneal neoplasm N.A. Approved [5]
Rectal adenocarcinoma 2B92 Approved [5]
Rectal neoplasm N.A. Approved [5]
Rectum mucinous adenocarcinoma N.A. Approved [5]
Adult glioblastoma N.A. Investigative [5]
Colon cancer 2B90.Z Investigative [5]
Colon mucinous adenocarcinoma N.A. Investigative [5]
Diarrhea ME05.1 Investigative [5]
Gastric cancer 2B72 Investigative [5]
Neuroblastoma 2D11.2 Investigative [5]
Irinotecan Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
DNA topoisomerase I (TOP1) TTGTQHC TOP1_HUMAN Modulator [14]
------------------------------------------------------------------------------------
Irinotecan Interacts with 6 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [89]
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [90]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [90]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [91]
Multidrug resistance-associated protein 4 (ABCC4) DTCSGPB MRP4_HUMAN Substrate [92]
Multidrug resistance-associated protein 5 (ABCC5) DTYVM24 MRP5_HUMAN Substrate [93]
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⏷ Show the Full List of 6 DTP(s)
Irinotecan Interacts with 8 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [94]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [95]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Metabolism [96]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Metabolism [97]
Carboxylesterase 1 (CES1) DEB30C5 EST1_HUMAN Metabolism [94]
Carboxylesterase 3 (CES3) DEMI4VE EST3_HUMAN Metabolism [98]
Carboxylesterase 2 (CES2) DETHCPD EST2_HUMAN Metabolism [98]
Beta-glucuronidase (uidA) DE9RA0I BGLR_ECOLI Metabolism [99]
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⏷ Show the Full List of 8 DME(s)
Irinotecan Interacts with 469 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Increases Expression [100]
Carboxylesterase 3 (CES3) OT00OP43 EST3_HUMAN Increases Hydrolysis [98]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases Response To Substance [101]
Liver carboxylesterase 1 (CES1) OT9L0LR8 EST1_HUMAN Increases Response To Substance [101]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Decreases Expression [84]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Decreases Response To Substance [102]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Increases Response To Substance [101]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Response To Substance [102]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Increases ADR [103]
Thiopurine S-methyltransferase (TPMT) OTFOX70W TPMT_HUMAN Increases Expression [84]
Cytochrome P450 2A6 (CYP2A6) OT52TWG3 CP2A6_HUMAN Decreases Activity [104]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Decreases Activity [104]
Annexin A2 (ANXA2) OTFNS0CC ANXA2_HUMAN Increases Expression [105]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Increases Expression [105]
FXYD domain-containing ion transport regulator 3 (FXYD3) OT9PPRHE FXYD3_HUMAN Increases Expression [105]
B-cell CLL/lymphoma 9 protein (BCL9) OTRBIPR4 BCL9_HUMAN Increases Expression [83]
Chromodomain-helicase-DNA-binding protein 1 (CHD1) OT9R9G0H CHD1_HUMAN Decreases Expression [83]
Prostaglandin E synthase (PTGES) OTB7YQFU PTGES_HUMAN Increases Expression [83]
tRNA (TRDMT1) OTAYQ8ZF TRDMT_HUMAN Decreases Expression [83]
Guanine nucleotide exchange factor DBS (MCF2L) OTEURA8N MCF2L_HUMAN Decreases Expression [83]
Fanconi anemia group G protein (FANCG) OT7MC8TZ FANCG_HUMAN Increases Expression [83]
Monocarboxylate transporter 5 (SLC16A4) OT1YXBKC MOT5_HUMAN Decreases Expression [83]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [83]
Prominin-1 (PROM1) OTBHV8NX PROM1_HUMAN Decreases Expression [83]
A-kinase anchor protein 10, mitochondrial (AKAP10) OTPNFTOU AKA10_HUMAN Decreases Expression [83]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) OT80DZMT BUB1_HUMAN Decreases Expression [83]
Hyaluronan mediated motility receptor (HMMR) OT4M0JTZ HMMR_HUMAN Decreases Expression [83]
G2/mitotic-specific cyclin-B2 (CCNB2) OTIEXTDK CCNB2_HUMAN Decreases Expression [83]
Heat shock 70 kDa protein 4L (HSPA4L) OT181WZB HS74L_HUMAN Decreases Expression [83]
Aldehyde dehydrogenase 1A1 (ALDH1A1) OTCUWZKB AL1A1_HUMAN Decreases Expression [83]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [83]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [83]
Lactotransferrin (LTF) OT8JWCZ0 TRFL_HUMAN Decreases Expression [83]
Histidine-rich glycoprotein (HRG) OTPLUFOG HRG_HUMAN Increases Expression [83]
Thy-1 membrane glycoprotein (THY1) OTVONVTB THY1_HUMAN Increases Expression [83]
Insulin-like growth factor I (IGF1) OTIIZR61 IGF1_HUMAN Increases Expression [83]
Myeloperoxidase (MPO) OTOOXLIN PERM_HUMAN Decreases Expression [83]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [83]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [83]
Integrin alpha-V (ITGAV) OTAM7JTR ITAV_HUMAN Decreases Expression [83]
Annexin A6 (ANXA6) OT9KIQ0Y ANXA6_HUMAN Increases Expression [83]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Increases Expression [83]
Sulfotransferase 1A3 (SULT1A4) OTHJ8WWV ST1A3_HUMAN Increases Expression [83]
Serine/threonine-protein kinase A-Raf (ARAF) OTZJ0FNO ARAF_HUMAN Increases Expression [83]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Decreases Expression [83]
Collagen alpha-1(VI) chain (COL6A1) OTYKSCOB CO6A1_HUMAN Increases Expression [83]
Keratin, type II cytoskeletal 5 (KRT5) OTVGI9HT K2C5_HUMAN Decreases Expression [83]
Nidogen-1 (NID1) OTKLBLS6 NID1_HUMAN Increases Expression [83]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Increases Expression [83]
Protein C-ets-2 (ETS2) OTPVHOZ7 ETS2_HUMAN Increases Expression [83]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [83]
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PPP3CB) OTEGNEHW PP2BB_HUMAN Decreases Expression [83]
SH2/SH3 adapter protein NCK1 (NCK1) OTKYZ4OP NCK1_HUMAN Decreases Expression [83]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Increases Expression [83]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [83]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [83]
Interferon-induced GTP-binding protein Mx2 (MX2) OT05NF37 MX2_HUMAN Decreases Expression [83]
Integrin alpha-X (ITGAX) OTOGIMHE ITAX_HUMAN Increases Expression [83]
Myelin and lymphocyte protein (MAL) OTBM30SW MAL_HUMAN Increases Expression [83]
Glutathione peroxidase 3 (GPX3) OT6PK94R GPX3_HUMAN Increases Expression [83]
5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS2) OTJXOUCL HEM0_HUMAN Increases Expression [83]
Receptor-type tyrosine-protein phosphatase delta (PTPRD) OTZPJ3GX PTPRD_HUMAN Increases Expression [83]
Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) OTGP7D5Y GATA3_HUMAN Decreases Expression [83]
Adenomatous polyposis coli protein (APC) OTKV0TIK APC_HUMAN Decreases Expression [83]
Retinoblastoma-like protein 1 (RBL1) OTDEBFYC RBL1_HUMAN Decreases Expression [83]
AT-rich interactive domain-containing protein 4A (ARID4A) OT1XKBZ0 ARI4A_HUMAN Decreases Expression [83]
M-phase inducer phosphatase 2 (CDC25B) OT12MSRY MPIP2_HUMAN Decreases Expression [83]
Syndecan-4 (SDC4) OTKUVUGZ SDC4_HUMAN Increases Expression [83]
C-C chemokine receptor type 1 (CCR1) OT4FC783 CCR1_HUMAN Increases Expression [83]
G-protein coupled receptor 183 (GPR183) OTRILX7G GP183_HUMAN Increases Expression [83]
CD70 antigen (CD70) OTHB2AL1 CD70_HUMAN Increases Expression [83]
T-lymphocyte activation antigen CD80 (CD80) OTJBLUQE CD80_HUMAN Increases Expression [83]
Dual specificity protein kinase TTK (TTK) OTBY1Z5H TTK_HUMAN Decreases Expression [83]
DNA replication licensing factor MCM4 (MCM4) OT19PNNG MCM4_HUMAN Decreases Expression [83]
Replication factor C subunit 3 (RFC3) OT1MS7AO RFC3_HUMAN Decreases Expression [83]
Cyclin-F (CCNF) OTJFVU43 CCNF_HUMAN Decreases Expression [83]
Transcription factor ETV6 (ETV6) OTCZMG61 ETV6_HUMAN Decreases Expression [83]
DNA mismatch repair protein Msh2 (MSH2) OT10H1AB MSH2_HUMAN Decreases Expression [83]
Hydroxycarboxylic acid receptor 3 (HCAR3) OTJBHLX0 HCAR3_HUMAN Increases Expression [83]
Centromere protein F (CENPF) OT7AG0SW CENPF_HUMAN Decreases Expression [83]
Caspase-4 (CASP4) OTVQTV1L CASP4_HUMAN Decreases Expression [83]
5-formyltetrahydrofolate cyclo-ligase (MTHFS) OTZ39JNR MTHFS_HUMAN Decreases Expression [83]
Protein Tob1 (TOB1) OTNW949D TOB1_HUMAN Increases Expression [83]
C-C chemokine receptor type 6 (CCR6) OT61JMYX CCR6_HUMAN Decreases Expression [83]
Serine/threonine-protein kinase Nek2 (NEK2) OT1H27HO NEK2_HUMAN Decreases Expression [83]
Serine/threonine-protein kinase PLK1 (PLK1) OTRZX45T PLK1_HUMAN Decreases Expression [83]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Increases Expression [83]
UV excision repair protein RAD23 homolog B (RAD23B) OT0PGOG3 RD23B_HUMAN Decreases Expression [83]
Sestrin-2 (SESN2) OT889IXY SESN2_HUMAN Increases Expression [83]
Neutrophil defensin 1 (DEFA1) OT5N1B9B DEF1_HUMAN Decreases Expression [83]
Ras-related C3 botulinum toxin substrate 3 (RAC3) OT2RE7A7 RAC3_HUMAN Increases Expression [83]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6) OT1SLUZH TSG6_HUMAN Decreases Expression [83]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Expression [83]
Runt-related transcription factor 1 (RUNX1) OTU7J84H RUNX1_HUMAN Decreases Expression [83]
Transcription factor Spi-B (SPIB) OTO4YKYI SPIB_HUMAN Increases Expression [83]
Myocyte-specific enhancer factor 2B (MEF2B) OT880SE6 MEF2B_HUMAN Increases Expression [83]
DNA-binding protein inhibitor ID-2 (ID2) OT0U1D53 ID2_HUMAN Decreases Expression [83]
Dual specificity protein phosphatase 2 (DUSP2) OTH54FMR DUS2_HUMAN Increases Expression [83]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B) OTOA8WU2 PDE4B_HUMAN Decreases Expression [83]
Regulator of G-protein signaling 1 (RGS1) OTGXJYMG RGS1_HUMAN Increases Expression [83]
Dystrophia myotonica WD repeat-containing protein (DMWD) OT0CBZ6F DMWD_HUMAN Increases Expression [83]
Histone acetyltransferase p300 (EP300) OTL8QJDX EP300_HUMAN Decreases Expression [83]
Dihydropyrimidine dehydrogenase (DPYD) OTWRF2NR DPYD_HUMAN Decreases Expression [83]
Tyrosine-protein phosphatase non-receptor type 13 (PTPN13) OTESFZSO PTN13_HUMAN Decreases Expression [83]
Rho GTPase-activating protein 5 (ARHGAP5) OTOQELUN RHG05_HUMAN Decreases Expression [83]
MAL-like protein (MALL) OTKGZ89D MALL_HUMAN Increases Expression [83]
TNF receptor-associated factor 1 (TRAF1) OTTLM5RU TRAF1_HUMAN Decreases Expression [83]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) OTXNGZCG MD2L1_HUMAN Decreases Expression [83]
Cyclin-dependent kinase 5 activator 2 (CDK5R2) OTNUTLPU CD5R2_HUMAN Increases Expression [83]
Centromere protein R (ITGB3BP) OT6Q7GR3 CENPR_HUMAN Decreases Expression [83]
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) OTPLXCDN DYR1A_HUMAN Decreases Expression [83]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Increases Expression [83]
Krueppel-like factor 9 (KLF9) OTBFEJRQ KLF9_HUMAN Increases Expression [83]
Cyclin-dependent kinase 13 (CDK13) OT3P7JF1 CDK13_HUMAN Decreases Expression [83]
Protein Tob2 (TOB2) OTEEHL60 TOB2_HUMAN Increases Expression [83]
Serine/threonine-protein kinase 38 (STK38) OTKMYCYR STK38_HUMAN Increases Expression [83]
Retinoblastoma-binding protein 5 (RBBP5) OT12W2MK RBBP5_HUMAN Decreases Expression [83]
Receptor tyrosine-protein kinase erbB-4 (ERBB4) OT9L6C41 ERBB4_HUMAN Increases Expression [83]
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF2) OTRHB9SR NHRF2_HUMAN Increases Expression [83]
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) OTBOSJHO TRADD_HUMAN Increases Expression [83]
Nuclear receptor coactivator 1 (NCOA1) OTLIUJQD NCOA1_HUMAN Increases Expression [83]
Tubulin-specific chaperone C (TBCC) OTBF0X8R TBCC_HUMAN Increases Expression [83]
Cyclin-dependent kinase inhibitor 3 (CDKN3) OTBE3H07 CDKN3_HUMAN Decreases Expression [83]
Receptor-type tyrosine-protein phosphatase-like N (PTPRN) OTAP7NOL PTPRN_HUMAN Increases Expression [83]
B-cell CLL/lymphoma 7 protein family member A (BCL7A) OTYFUJTP BCL7A_HUMAN Increases Expression [83]
Transmembrane protein 41B (TMEM41B) OTW0B0KS TM41B_HUMAN Decreases Expression [83]
Transcription initiation factor TFIID subunit 2 (TAF2) OTTIGJ9M TAF2_HUMAN Decreases Expression [83]
DNA cross-link repair 1A protein (DCLRE1A) OT68PVSD DCR1A_HUMAN Decreases Expression [83]
C-myc promoter-binding protein (DENND4A) OT8FFZ29 MYCPP_HUMAN Decreases Expression [83]
COMM domain-containing protein 6 (COMMD6) OTRZQJFW COMD6_HUMAN Increases Expression [83]
Bone morphogenetic protein 8A (BMP8A) OT1997IN BMP8A_HUMAN Increases Expression [83]
Pleckstrin homology domain-containing family H member 3 (PLEKHH3) OTREOQBO PKHH3_HUMAN Increases Expression [83]
DNA damage-binding protein 2 (DDB2) OTO8HVVB DDB2_HUMAN Increases Expression [83]
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) OTMDVWPS DYRK2_HUMAN Decreases Expression [83]
Histone H2A type 1-C (H2AC6) OTF3YK7V H2A1C_HUMAN Decreases Expression [83]
Aurora kinase B (AURKB) OTIY4VHU AURKB_HUMAN Decreases Expression [83]
Sorting nexin-18 (SNX18) OT68KT3X SNX18_HUMAN Decreases Expression [83]
Oncostatin-M-specific receptor subunit beta (OSMR) OTORWHPL OSMR_HUMAN Increases Expression [83]
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) OTQR6ENW M3K5_HUMAN Decreases Expression [83]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [83]
Ubiquitin-like-conjugating enzyme ATG10 (ATG10) OTVRPC5X ATG10_HUMAN Decreases Expression [83]
Serine/threonine-protein kinase PLK3 (PLK3) OT19CT2Z PLK3_HUMAN Increases Expression [83]
E3 ubiquitin-protein ligase Topors (TOPORS) OT1ERFFQ TOPRS_HUMAN Decreases Expression [83]
Serine/threonine-protein kinase PLK2 (PLK2) OTKMJXJ8 PLK2_HUMAN Increases Expression [83]
Gamma-adducin (ADD3) OTDRSHAZ ADDG_HUMAN Decreases Expression [83]
Targeting protein for Xklp2 (TPX2) OTWLJYH0 TPX2_HUMAN Decreases Expression [83]
Protocadherin gamma-C3 (PCDHGC3) OTDXTUMI PCDGK_HUMAN Increases Expression [83]
Tyrosine-protein phosphatase non-receptor type 22 (PTPN22) OTDCNTC3 PTN22_HUMAN Increases Expression [83]
Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1) OTBV52DR SMHD1_HUMAN Decreases Expression [84]
Serine/threonine-protein kinase Sgk1 (SGK1) OT301T1U SGK1_HUMAN Increases Expression [84]
Matrilin-2 (MATN2) OTVDR68G MATN2_HUMAN Increases Expression [84]
Krev interaction trapped protein 1 (KRIT1) OT58AP1I KRIT1_HUMAN Decreases Expression [84]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Decreases Expression [84]
Calmegin (CLGN) OTEWVFQV CLGN_HUMAN Increases Expression [84]
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) OTB3BFCV HNRDL_HUMAN Decreases Expression [84]
Centrosomal protein of 290 kDa (CEP290) OTVN52VH CE290_HUMAN Decreases Expression [84]
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (ANKRD28) OTRBREQ9 ANR28_HUMAN Decreases Expression [84]
FYN-binding protein 1 (FYB1) OT6345CH FYB1_HUMAN Decreases Expression [84]
Protein phosphatase 1D (PPM1D) OT8NLZ9D PPM1D_HUMAN Increases Expression [84]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Decreases Expression [84]
Krueppel-like factor 4 (KLF4) OT4O9RQW KLF4_HUMAN Increases Expression [84]
Density-regulated protein (DENR) OTXP9HOY DENR_HUMAN Decreases Expression [84]
E3 ubiquitin-protein ligase MARCHF6 (MARCHF6) OTBTA03N MARH6_HUMAN Increases Expression [84]
Oligophrenin-1 (OPHN1) OTDURZAV OPHN1_HUMAN Increases Expression [84]
NEDD4-binding protein 1 (N4BP1) OTN2TL6N N4BP1_HUMAN Decreases Expression [84]
Ankyrin repeat domain-containing protein 17 (ANKRD17) OTQ3DYEP ANR17_HUMAN Decreases Expression [84]
Nuclear receptor corepressor 1 (NCOR1) OT04XNOU NCOR1_HUMAN Decreases Expression [84]
Death effector domain-containing protein (DEDD) OTIL349E DEDD_HUMAN Decreases Expression [84]
Glutaredoxin-3 (GLRX3) OTUPAU1N GLRX3_HUMAN Affects Expression [84]
Tubulin polymerization-promoting protein (TPPP) OTCFMSUF TPPP_HUMAN Increases Expression [84]
Protein transport protein Sec31A (SEC31A) OT2U42AC SC31A_HUMAN Decreases Expression [84]
SR-related and CTD-associated factor 4 (SCAF4) OTFGHB1E SCAF4_HUMAN Decreases Expression [84]
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) OT9QIHEQ RECK_HUMAN Increases Expression [84]
Tissue-type plasminogen activator (PLAT) OTQPDNAB TPA_HUMAN Decreases Expression [84]
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Decreases Expression [84]
HLA class I histocompatibility antigen, B alpha chain (HLA-B) OTNXFWY2 HLAB_HUMAN Decreases Expression [84]
HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1) OTRGGIFP DRB1_HUMAN Increases Expression [84]
Myelin basic protein (MBP) OTFZCEDB MBP_HUMAN Decreases Expression [84]
Fibronectin (FN1) OTB5ZN4Q FINC_HUMAN Increases Expression [84]
Albumin (ALB) OTVMM513 ALBU_HUMAN Decreases Expression [84]
Transferrin receptor protein 1 (TFRC) OT8ZPBDL TFR1_HUMAN Increases Expression [84]
Alpha-enolase (ENO1) OTB1KWJS ENOA_HUMAN Decreases Expression [84]
Transcription factor Sp1 (SP1) OTISPT4X SP1_HUMAN Decreases Expression [84]
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) OTIRPN6B ROA1_HUMAN Decreases Expression [84]
U2 small nuclear ribonucleoprotein A' (SNRPA1) OTWJZFAP RU2A_HUMAN Decreases Expression [84]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Increases Expression [84]
Chorionic somatomammotropin hormone 2 (CSH2) OTW8JVAN CSH2_HUMAN Decreases Expression [84]
Tissue factor pathway inhibitor (TFPI) OTA0FX16 TFPI1_HUMAN Decreases Expression [84]
Breakpoint cluster region protein (BCR) OTCN76C1 BCR_HUMAN Decreases Expression [84]
Interferon-induced transmembrane protein 1 (IFITM1) OTECO1G8 IFM1_HUMAN Increases Expression [84]
HLA class II histocompatibility antigen, DR beta 4 chain (HLA-DRB4) OTNXIHQU DRB4_HUMAN Increases Expression [84]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Decreases Expression [84]
Arylsulfatase B (ARSB) OTTYDDNU ARSB_HUMAN Decreases Expression [84]
Carboxypeptidase E (CPE) OTXNTV79 CBPE_HUMAN Increases Expression [84]
Integrin alpha-2 (ITGA2) OTPFL017 ITA2_HUMAN Increases Expression [84]
Gap junction alpha-1 protein (GJA1) OTT94MKL CXA1_HUMAN Affects Expression [84]
Peptidyl-glycine alpha-amidating monooxygenase (PAM) OTX8HV5B AMD_HUMAN Decreases Expression [84]
Glutathione hydrolase 1 proenzyme (GGT1) OTYDA1Z7 GGT1_HUMAN Decreases Expression [84]
Ras GTPase-activating protein 1 (RASA1) OTZJ3LP4 RASA1_HUMAN Decreases Expression [84]
Synaptotagmin-1 (SYT1) OTVTPOI6 SYT1_HUMAN Decreases Expression [84]
Receptor-type tyrosine-protein phosphatase gamma (PTPRG) OT9N2WOF PTPRG_HUMAN Decreases Expression [84]
Paired box protein Pax-7 (PAX7) OTDMQRPO PAX7_HUMAN Decreases Expression [84]
Annexin A13 (ANXA13) OTM33P73 ANX13_HUMAN Decreases Expression [84]
Lens fiber major intrinsic protein (MIP) OTEBLU3E MIP_HUMAN Decreases Expression [84]
Fibroblast growth factor 9 (FGF9) OT2SKDGM FGF9_HUMAN Decreases Expression [84]
Glycerol kinase (GK) OTK2YRA0 GLPK_HUMAN Decreases Expression [84]
Cystathionine gamma-lyase (CTH) OTC90LA0 CGL_HUMAN Increases Expression [84]
Myosin-10 (MYH10) OTXN2WXS MYH10_HUMAN Decreases Expression [84]
Large ribosomal subunit protein uL4 (RPL4) OTTYJB0X RL4_HUMAN Decreases Expression [84]
T-complex protein 1 subunit zeta (CCT6A) OTCYWL5F TCPZ_HUMAN Decreases Expression [84]
Reduced folate transporter (SLC19A1) OTWB0BTO S19A1_HUMAN Decreases Expression [84]
Matrin-3 (MATR3) OTESJ5S7 MATR3_HUMAN Decreases Expression [84]
Transcriptional regulator ATRX (ATRX) OT77RSQW ATRX_HUMAN Decreases Expression [84]
Vesicle-fusing ATPase (NSF) OTKRJ2ZT NSF_HUMAN Decreases Expression [84]
Stromal cell-derived factor 1 (CXCL12) OT2QX5LL SDF1_HUMAN Decreases Expression [84]
Nuclear pore complex protein Nup153 (NUP153) OTCAS0AR NU153_HUMAN Decreases Expression [84]
Gastrotropin (FABP6) OTIRQWLW FABP6_HUMAN Increases Expression [84]
Host cell factor 1 (HCFC1) OT0UCK62 HCFC1_HUMAN Decreases Expression [84]
Collagen alpha-4(IV) chain (COL4A4) OT9G0MCT CO4A4_HUMAN Decreases Expression [84]
Coatomer subunit alpha (COPA) OTZ1DTXU COPA_HUMAN Increases Expression [84]
Cadherin-4 (CDH4) OT8LH3HN CADH4_HUMAN Decreases Expression [84]
C-terminal-binding protein 2 (CTBP2) OTGZGT87 CTBP2_HUMAN Decreases Expression [84]
ADP-ribosylation factor-like protein 4C (ARL4C) OTQ3QNNU ARL4C_HUMAN Increases Expression [84]
Epiplakin (EPPK1) OT7BAU8C EPIPL_HUMAN Increases Expression [84]
Lysyl oxidase homolog 3 (LOXL3) OTLLY1QI LOXL3_HUMAN Decreases Expression [84]
Histone H4 (H4C1) OTB71W46 H4_HUMAN Decreases Expression [84]
AP-2 complex subunit beta (AP2B1) OTL6LZJ4 AP2B1_HUMAN Decreases Expression [84]
Hemoglobin subunit gamma-1 (HBG1) OTVL4NSU HBG1_HUMAN Decreases Expression [84]
Mothers against decapentaplegic homolog 3 (SMAD3) OTNA96MR SMAD3_HUMAN Decreases Expression [84]
ADP-ribosylation factor 1 (ARF1) OT5C4C3L ARF1_HUMAN Decreases Expression [84]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Affects Expression [84]
Clathrin heavy chain 1 (CLTC) OTBFASMA CLH1_HUMAN Decreases Expression [84]
Centromere-associated protein E (CENPE) OTQ7AP04 CENPE_HUMAN Decreases Expression [84]
Paired box protein Pax-5 (PAX5) OTYBJJWX PAX5_HUMAN Decreases Expression [84]
Dystonin (DST) OTHZBM4X DYST_HUMAN Decreases Expression [84]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Decreases Expression [84]
Recombining binding protein suppressor of hairless (RBPJ) OTD7CUG0 SUH_HUMAN Decreases Expression [84]
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) OT5GO2PL KHDR1_HUMAN Decreases Expression [84]
Protein phosphatase 3 catalytic subunit alpha (PPP3CA) OT58PUEN PP2BA_HUMAN Decreases Expression [84]
Leukocyte surface antigen CD47 (CD47) OTLDZ0KZ CD47_HUMAN Increases Expression [84]
Transmembrane protein 267 (TMEM267) OTEAAVK7 TM267_HUMAN Decreases Expression [84]
Proline-rich nuclear receptor coactivator 1 (PNRC1) OTQMLEE1 PNRC1_HUMAN Increases Expression [84]
Alpha-globin transcription factor CP2 (TFCP2) OTA246TE TFCP2_HUMAN Decreases Expression [84]
Disks large homolog 1 (DLG1) OTCRZYWT DLG1_HUMAN Decreases Expression [84]
Serine/threonine-protein kinase 4 (STK4) OTBRYNNH STK4_HUMAN Decreases Expression [84]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Decreases Expression [84]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) OT7TNF0L AAPK1_HUMAN Decreases Expression [84]
BMP and activin membrane-bound inhibitor homolog (BAMBI) OTCEJ8W5 BAMBI_HUMAN Increases Expression [84]
Dynactin subunit 2 (DCTN2) OTMB4IXD DCTN2_HUMAN Increases Expression [84]
Cullin-4A (CUL4A) OTTBV70J CUL4A_HUMAN Decreases Expression [84]
Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) OT5UO1FA HNRPD_HUMAN Decreases Expression [84]
Guanine nucleotide-binding protein subunit alpha-13 (GNA13) OTVDL515 GNA13_HUMAN Increases Expression [84]
Disco-interacting protein 2 homolog A (DIP2A) OTXPTR8R DIP2A_HUMAN Decreases Expression [84]
Uncharacterized protein KIAA0040 (KIAA0040) OT27EBY3 K0040_HUMAN Increases Expression [84]
Kinesin-like protein KIF14 (KIF14) OTXHT4JM KIF14_HUMAN Decreases Expression [84]
Transforming growth factor-beta-induced protein ig-h3 (TGFBI) OTR443C5 BGH3_HUMAN Decreases Expression [84]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Increases Expression [84]
MICOS complex subunit MIC60 (IMMT) OTBDSLE7 MIC60_HUMAN Affects Expression [84]
WD40 repeat-containing protein SMU1 (SMU1) OTLCSLGL SMU1_HUMAN Decreases Expression [84]
Neuroblastoma breakpoint family member 1 (NBPF1) OTAZ55UQ NBPF1_HUMAN Decreases Expression [84]
Cell adhesion molecule-related/down-regulated by oncogenes (CDON) OT81X593 CDON_HUMAN Decreases Expression [84]
Protein LBH (LBH) OT87AT1X LBH_HUMAN Decreases Expression [84]
Shugoshin 2 (SGO2) OTNGJDS8 SGO2_HUMAN Decreases Expression [84]
PAN2-PAN3 deadenylation complex subunit PAN3 (PAN3) OTYBA69S PAN3_HUMAN Decreases Expression [84]
Sterile alpha motif domain-containing protein 9 (SAMD9) OTDG48P0 SAMD9_HUMAN Increases Expression [84]
Serine/threonine-protein phosphatase 4 regulatory subunit 3B (PPP4R3B) OT1VTUL9 P4R3B_HUMAN Decreases Expression [84]
Acyl-coenzyme A thioesterase THEM4 (THEM4) OTSIZU8Y THEM4_HUMAN Decreases Expression [84]
MAGUK p55 subfamily member 7 (MPP7) OT3G3HTZ MPP7_HUMAN Increases Expression [84]
DDB1- and CUL4-associated factor 8 (DCAF8) OT3VFSLG DCAF8_HUMAN Decreases Expression [84]
Collagen alpha-1(XIII) chain (COL13A1) OTM9IM6J CODA1_HUMAN Increases Expression [84]
Probable E3 ubiquitin-protein ligase HECTD2 (HECTD2) OTDIBGQV HECD2_HUMAN Decreases Expression [84]
Serine/threonine-protein kinase MRCK alpha (CDC42BPA) OTCPFOSA MRCKA_HUMAN Decreases Expression [84]
Rho GTPase-activating protein SYDE2 (SYDE2) OTOEIXSM SYDE2_HUMAN Increases Expression [84]
Deubiquitinase MYSM1 (MYSM1) OTO73N00 MYSM1_HUMAN Decreases Expression [84]
AT-rich interactive domain-containing protein 2 (ARID2) OTIRJXWM ARID2_HUMAN Decreases Expression [84]
Glucose 1,6-bisphosphate synthase (PGM2L1) OTSBNRT5 PGM2L_HUMAN Increases Expression [84]
UPF0547 protein C16orf87 (C16ORF87) OT658H5A CP087_HUMAN Decreases Expression [84]
Kelch-like protein 24 (KLHL24) OTWZSX5C KLH24_HUMAN Increases Expression [84]
Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) OTV01EFP C1TM_HUMAN Decreases Expression [84]
Rho-related GTP-binding protein RhoU (RHOU) OTERIAD4 RHOU_HUMAN Increases Expression [84]
Protein ABHD13 (ABHD13) OTF2E8M6 ABHDD_HUMAN Decreases Expression [84]
G2/M phase-specific E3 ubiquitin-protein ligase (G2E3) OT06BFRQ G2E3_HUMAN Decreases Expression [84]
Diphthine--ammonia ligase (DPH6) OTOJ7BXR DPH6_HUMAN Decreases Expression [84]
Pogo transposable element with ZNF domain (POGZ) OT4CYWC1 POGZ_HUMAN Decreases Expression [84]
FERM domain-containing protein 5 (FRMD5) OTC73XJK FRMD5_HUMAN Decreases Expression [84]
Phosphatidylinositol-glycan biosynthesis class W protein (PIGW) OTT9SMTF PIGW_HUMAN Decreases Expression [84]
Amphoterin-induced protein 2 (AMIGO2) OTPAIT1O AMGO2_HUMAN Increases Expression [84]
Dihydrofolate reductase 2, mitochondrial (DHFR2) OTPHUWEY DYR2_HUMAN Decreases Expression [84]
ELKS/Rab6-interacting/CAST family member 1 (ERC1) OTYBGGNO RB6I2_HUMAN Decreases Expression [84]
Armadillo repeat-containing protein 8 (ARMC8) OTNAXGM7 ARMC8_HUMAN Decreases Expression [84]
Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3) OTNJX38T M4K3_HUMAN Decreases Expression [84]
Protein FAM219A (FAM219A) OTAFZHY9 F219A_HUMAN Decreases Expression [84]
Homeobox protein Mohawk (MKX) OT7H7Z50 MKX_HUMAN Decreases Expression [84]
Threonine synthase-like 1 (THNSL1) OTQNFH3E THNS1_HUMAN Decreases Expression [84]
Porimin (TMEM123) OTDMVZD6 PORIM_HUMAN Decreases Expression [84]
Rho guanine nucleotide exchange factor 39 (ARHGEF39) OT9UKTQ5 ARG39_HUMAN Decreases Expression [84]
Type 2 DNA topoisomerase 6 subunit B-like (TOP6BL) OTCYPUNK TO6BL_HUMAN Increases Expression [84]
Protein SCAI (SCAI) OTAK3TMO SCAI_HUMAN Decreases Expression [84]
Diacylglycerol lipase-beta (DAGLB) OT1S9869 DGLB_HUMAN Decreases Expression [84]
Regulator of G-protein signaling 22 (RGS22) OTCTFGW6 RGS22_HUMAN Decreases Expression [84]
Phospholipase DDHD1 (DDHD1) OTWTHOWK DDHD1_HUMAN Decreases Expression [84]
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) OTCV7AGV PCAT1_HUMAN Decreases Expression [84]
Biorientation of chromosomes in cell division protein 1-like 1 (BOD1L1) OTTD5FJ8 BD1L1_HUMAN Decreases Expression [84]
Atlastin-2 (ATL2) OT93AUOO ATLA2_HUMAN Increases Expression [84]
Centrosomal protein of 192 kDa (CEP192) OTBLFV7T CE192_HUMAN Decreases Expression [84]
DEP domain-containing protein 1B (DEPDC1B) OTMVFOT1 DEP1B_HUMAN Decreases Expression [84]
Pleckstrin homology-like domain family A member 1 (PHLDA1) OTFTWMIQ PHLA1_HUMAN Decreases Expression [84]
Microprocessor complex subunit DGCR8 (DGCR8) OT62LXE4 DGCR8_HUMAN Decreases Expression [84]
Tribbles homolog 2 (TRIB2) OTHSX3MX TRIB2_HUMAN Affects Expression [84]
Protein FAM3C (FAM3C) OTBR6U9G FAM3C_HUMAN Decreases Expression [84]
CREB-binding protein (CREBBP) OTPA4QGM CBP_HUMAN Decreases Expression [84]
Histone acetyltransferase KAT2B (KAT2B) OTWQITWK KAT2B_HUMAN Increases Expression [84]
Homeobox protein DLX-4 (DLX4) OTLWVCN4 DLX4_HUMAN Increases Expression [84]
Protein tyrosine phosphatase type IVA 1 (PTP4A1) OTK0NFXJ TP4A1_HUMAN Decreases Expression [84]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Increases Expression [84]
Exocyst complex component 4 (EXOC4) OT5EWXAN EXOC4_HUMAN Decreases Expression [84]
RalBP1-associated Eps domain-containing protein 1 (REPS1) OTX4ERRK REPS1_HUMAN Decreases Expression [84]
Protein LTV1 homolog (LTV1) OTZILJDI LTV1_HUMAN Decreases Expression [84]
PDZ and LIM domain protein 5 (PDLIM5) OTLQVV22 PDLI5_HUMAN Decreases Expression [84]
DISP complex protein LRCH3 (LRCH3) OTDLBLMU LRCH3_HUMAN Decreases Expression [84]
Rho GTPase-activating protein 7 (DLC1) OTP8LMCR RHG07_HUMAN Decreases Expression [84]
Tribbles homolog 1 (TRIB1) OTPEO17G TRIB1_HUMAN Increases Expression [84]
Mitochondrial inner membrane protease subunit 2 (IMMP2L) OT9WGAFD IMP2L_HUMAN Decreases Expression [84]
Transcription factor 12 (TCF12) OTZVONNU HTF4_HUMAN Decreases Expression [84]
ATP synthase subunit s, mitochondrial (DMAC2L) OT2OQ1UD ATP5S_HUMAN Decreases Expression [84]
Semaphorin-3C (SEMA3C) OTEGUY7F SEM3C_HUMAN Increases Expression [84]
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (DPH2) OT9P91XR DPH2_HUMAN Decreases Expression [84]
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) OTB78IF4 ODC_HUMAN Decreases Expression [84]
Deubiquitinase DESI2 (DESI2) OTHUOKOC DESI2_HUMAN Decreases Expression [84]
Acireductone dioxygenase (ADI1) OT8IOD03 MTND_HUMAN Decreases Expression [84]
Protein C1orf43 (C1ORF43) OTT9CVZR CA043_HUMAN Decreases Expression [84]
RNA-binding protein 24 (RBM24) OTQI1AR1 RBM24_HUMAN Increases Expression [84]
Nucleolar and spindle-associated protein 1 (NUSAP1) OT85HIJ5 NUSAP_HUMAN Decreases Expression [84]
E3 ubiquitin-protein ligase TRIM9 (TRIM9) OTKYG33W TRIM9_HUMAN Increases Expression [84]
E3 ubiquitin-protein ligase TRIM4 (TRIM4) OTLKQNKQ TRIM4_HUMAN Increases Expression [84]
Histone-lysine N-methyltransferase SETD5 (SETD5) OTRPAVEO SETD5_HUMAN Decreases Expression [84]
Alpha-ketoglutarate-dependent dioxygenase FTO (FTO) OTXML85Y FTO_HUMAN Decreases Expression [84]
Centrosomal protein of 295 kDa (CEP295) OTVTTXRO CE295_HUMAN Decreases Expression [84]
Sentrin-specific protease 6 (SENP6) OT05LLF4 SENP6_HUMAN Decreases Expression [84]
Cytochrome c oxidase assembly factor 1 homolog (COA1) OTHSX40F COA1_HUMAN Decreases Expression [84]
Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19) OTH88TXU ADA19_HUMAN Increases Expression [84]
Pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2) OTXV0ZD0 PHS2_HUMAN Decreases Expression [84]
Metal transporter CNNM2 (CNNM2) OTZHO8WU CNNM2_HUMAN Increases Expression [84]
Pleckstrin homology domain-containing family A member 5 (PLEKHA5) OT2MNW8T PKHA5_HUMAN Decreases Expression [84]
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) OTQDHSMI MCCB_HUMAN Decreases Expression [84]
E3 ubiquitin-protein ligase SMURF1 (SMURF1) OT5UIZR8 SMUF1_HUMAN Affects Expression [84]
Large ribosomal subunit protein mL65 (MRPS30) OTDXIAGG RT30_HUMAN Decreases Expression [84]
Transcription factor 7-like 2 (TCF7L2) OTVWPZ8B TF7L2_HUMAN Decreases Expression [84]
Muscleblind-like protein 1 (MBNL1) OTOV7J85 MBNL1_HUMAN Decreases Expression [84]
Lymphoid-specific helicase (HELLS) OTVVV668 HELLS_HUMAN Decreases Expression [84]
Phenylalanine--tRNA ligase beta subunit (FARSB) OT8N9TT5 SYFB_HUMAN Decreases Expression [84]
Midasin (MDN1) OTNBSPTW MDN1_HUMAN Affects Expression [84]
tRNA:m(4)X modification enzyme TRM13 homolog (TRMT13) OT2H0MCE TRM13_HUMAN Decreases Expression [84]
E3 ubiquitin-protein ligase RLIM (RLIM) OTEBRNHJ RNF12_HUMAN Decreases Expression [84]
G patch domain-containing protein 2-like (GPATCH2L) OTETUZ64 GPT2L_HUMAN Decreases Expression [84]
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1) OTFOJUIQ PHAG1_HUMAN Increases Expression [84]
Huntingtin-interacting protein K (HYPK) OTRWRVWN HYPK_HUMAN Affects Expression [84]
Inhibitor of growth protein 3 (ING3) OTDIJXFP ING3_HUMAN Decreases Expression [84]
Rho guanine nucleotide exchange factor 12 (ARHGEF12) OTM2D3LT ARHGC_HUMAN Decreases Expression [84]
Cysteine-rich motor neuron 1 protein (CRIM1) OTTZNV6Y CRIM1_HUMAN Decreases Expression [84]
Voltage-dependent T-type calcium channel subunit alpha-1I (CACNA1I) OTRH8X8A CAC1I_HUMAN Decreases Expression [84]
eIF-2-alpha kinase GCN2 (EIF2AK4) OTLE1JY8 E2AK4_HUMAN Affects Expression [84]
DNA polymerase kappa (POLK) OTKZ38JH POLK_HUMAN Decreases Expression [84]
Mediator of RNA polymerase II transcription subunit 13 (MED13) OTP5LEJE MED13_HUMAN Decreases Expression [84]
Jupiter microtubule associated homolog 1 (JPT1) OT6CRZEU JUPI1_HUMAN Decreases Expression [84]
BTB/POZ domain-containing protein 3 (BTBD3) OTZ607YT BTBD3_HUMAN Decreases Expression [84]
Thyroid hormone receptor-associated protein 3 (THRAP3) OTG25JOG TR150_HUMAN Decreases Expression [84]
rRNA-processing protein FCF1 homolog (FCF1) OTTI9M2D FCF1_HUMAN Affects Expression [84]
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMHD1) OTBCIBC7 SAMH1_HUMAN Affects Expression [84]
Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (HS3ST3B1) OTK53GUD HS3SB_HUMAN Increases Expression [84]
Calcineurin-binding protein cabin-1 (CABIN1) OT4G5CIK CABIN_HUMAN Decreases Expression [84]
Proton-coupled zinc antiporter SLC30A1 (SLC30A1) OTY8J0S4 ZNT1_HUMAN Decreases Expression [84]
Serine/threonine-protein kinase Chk1 (CHEK1) OTTTI622 CHK1_HUMAN Increases Phosphorylation [106]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [107]
Ubiquinone biosynthesis protein COQ9, mitochondrial (COQ9) OTM2T1FI COQ9_HUMAN Decreases Expression [86]
Interleukin-33 (IL33) OTT5YWK3 IL33_HUMAN Increases Expression [108]
Serine/threonine-protein kinase Chk2 (CHEK2) OT8ZPCNS CHK2_HUMAN Increases Phosphorylation [109]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Increases Expression [108]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Decreases Secretion [110]
Protransforming growth factor alpha (TGFA) OTPD1LL9 TGFA_HUMAN Increases Secretion [111]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Expression [112]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Expression [109]
Protein kinase C beta type (PRKCB) OTYQ0656 KPCB_HUMAN Increases Phosphorylation [111]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Affects Expression [113]
DNA excision repair protein ERCC-1 (ERCC1) OTNPYQHI ERCC1_HUMAN Decreases Expression [85]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [108]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Expression [114]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [111]
Amphiregulin (AREG) OTJFOR67 AREG_HUMAN Increases Expression [111]
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Decreases Expression [115]
Protein kinase C alpha type (PRKCA) OT5UWNRD KPCA_HUMAN Increases Phosphorylation [111]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Increases Activity [112]
3-mercaptopyruvate sulfurtransferase (MPST) OTCDPH5D THTM_HUMAN Decreases Expression [86]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [116]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Increases Expression [86]
Nitric oxide synthase, inducible (NOS2) OTKKIOJ1 NOS2_HUMAN Increases Expression [108]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Decreases Expression [108]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [117]
Protein kinase C iota type (PRKCI) OTKBAVT3 KPCI_HUMAN Increases Phosphorylation [111]
Signal transducer and activator of transcription 1-alpha/beta (STAT1) OTLMBUZ6 STAT1_HUMAN Increases Phosphorylation [116]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [118]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Decreases Expression [119]
Radiation-inducible immediate-early gene IEX-1 (IER3) OTZJI5FZ IEX1_HUMAN Increases Expression [86]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Activity [107]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [109]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Decreases Expression [120]
Rho-related GTP-binding protein RhoB (RHOB) OTHQFQF7 RHOB_HUMAN Increases Expression [86]
DNA-dependent protein kinase catalytic subunit (PRKDC) OTJVS4EG PRKDC_HUMAN Increases Phosphorylation [121]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Increases Activity [112]
Protein kinase C delta type (PRKCD) OTSEH90E KPCD_HUMAN Increases Phosphorylation [111]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Increases Expression [122]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [119]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Increases Phosphorylation [109]
Transcription factor HES-1 (HES1) OT8P19W2 HES1_HUMAN Increases Activity [123]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Activity [119]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Increases Expression [108]
Extracellular tyrosine-protein kinase PKDCC (PKDCC) OTVXJR26 PKDCC_HUMAN Decreases Expression [86]
Pleckstrin homology-like domain family A member 2 (PHLDA2) OTMV9DPP PHLA2_HUMAN Increases Expression [86]
Docking protein 6 (DOK6) OTX55OIF DOK6_HUMAN Decreases Expression [86]
tRNA-splicing endonuclease subunit Sen2 (TSEN2) OT1UWYRI SEN2_HUMAN Decreases Expression [86]
Protein FAN (NSMAF) OTYNVZ23 FAN_HUMAN Decreases Expression [86]
Probable ATP-dependent RNA helicase DDX17 (DDX17) OTXRMMBP DDX17_HUMAN Decreases Expression [86]
F-box/WD repeat-containing protein 5 (FBXW5) OT5TQK3H FBXW5_HUMAN Increases Expression [86]
PRKC apoptosis WT1 regulator protein (PAWR) OTKY7W52 PAWR_HUMAN Decreases Expression [86]
Proheparin-binding EGF-like growth factor (HBEGF) OTLU00JS HBEGF_HUMAN Increases Expression [111]
Homeobox protein HMX1 (HMX1) OT65ZGE0 HMX1_HUMAN Increases Expression [86]
Abl interactor 2 (ABI2) OT8GIIS5 ABI2_HUMAN Decreases Expression [86]
Inhibitor of Bruton tyrosine kinase (IBTK) OTB2GM4G IBTK_HUMAN Decreases Expression [86]
SERTA domain-containing protein 1 (SERTAD1) OTBHKZQP SRTD1_HUMAN Increases Expression [86]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Decreases Response To Substance [124]
Phospholipid phosphatase 1 (PLPP1) OT0IIMI5 PLPP1_HUMAN Decreases Response To Substance [124]
DNA polymerase alpha catalytic subunit (POLA1) OT1WXFVY DPOLA_HUMAN Increases Response To Substance [124]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Response To Substance [125]
Collagen alpha-1(VII) chain (COL7A1) OT3MIRZJ CO7A1_HUMAN Decreases Response To Substance [124]
Integrin alpha-E (ITGAE) OT41KCRX ITAE_HUMAN Increases Response To Substance [124]
Nicastrin (NCSTN) OT5QBTA4 NICA_HUMAN Affects Response To Substance [123]
V-type proton ATPase 21 kDa proteolipid subunit c'' (ATP6V0B) OT8GTI1V VATO_HUMAN Increases Response To Substance [124]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Affects Response To Substance [126]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1) OT9HYT7A PLCB1_HUMAN Increases ADR [127]
DNA polymerase epsilon subunit 2 (POLE2) OTAC9V6L DPOE2_HUMAN Increases Response To Substance [124]
Protein DBF4 homolog A (DBF4) OTBL7JHQ DBF4A_HUMAN Increases Response To Substance [124]
Glucocorticoid receptor (NR3C1) OTCI2YDI GCR_HUMAN Decreases Response To Substance [124]
Cell division cycle protein 20 homolog (CDC20) OTCOEZRV CDC20_HUMAN Increases Response To Substance [124]
RNA-binding motif, single-stranded-interacting protein 1 (RBMS1) OTD13PJN RBMS1_HUMAN Decreases Response To Substance [124]
S-phase kinase-associated protein 2 (SKP2) OTD5B41X SKP2_HUMAN Increases Response To Substance [124]
Pre-B-cell leukemia transcription factor-interacting protein 1 (PBXIP1) OTEAAUBY PBIP1_HUMAN Decreases Response To Substance [124]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Increases Response To Substance [128]
DNA mismatch repair protein Mlh1 (MLH1) OTG5XDD8 MLH1_HUMAN Affects Response To Substance [126]
Origin recognition complex subunit 1 (ORC1) OTHWU8IJ ORC1_HUMAN Increases Response To Substance [124]
U6 snRNA-associated Sm-like protein LSm7 (LSM7) OTHZ2XPX LSM7_HUMAN Increases Response To Substance [124]
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) OTJC60Q7 THIL_HUMAN Increases Response To Substance [124]
Transcriptional activator Myb (MYB) OTJH64IV MYB_HUMAN Increases Response To Substance [124]
CCN family member 1 (CCN1) OTKJBEMD CCN1_HUMAN Decreases Response To Substance [124]
Ras-related protein Rab-31 (RAB31) OTMLXQZ0 RAB31_HUMAN Decreases Response To Substance [124]
Copper-transporting ATPase 1 (ATP7A) OTMR3GXP ATP7A_HUMAN Decreases Response To Substance [129]
Plasma membrane calcium-transporting ATPase 4 (ATP2B4) OTMWFDAC AT2B4_HUMAN Decreases Response To Substance [124]
E3 ubiquitin-protein ligase CCNB1IP1 (CCNB1IP1) OTOTVMC8 CIP1_HUMAN Increases Response To Substance [124]
Protein FAM50B (FAM50B) OTP3H38A FA50B_HUMAN Increases ADR [130]
DNA fragmentation factor subunit beta (DFFB) OTPBW5N5 DFFB_HUMAN Increases Response To Substance [124]
ATP-binding cassette sub-family B member 6 (ABCB6) OTPGZFES ABCB6_HUMAN Decreases Response To Substance [131]
E3 ubiquitin-protein ligase RNF34 (RNF34) OTQY58LU RNF34_HUMAN Decreases Response To Substance [118]
DNA-directed RNA polymerase III subunit RPC7 (POLR3G) OTU3TGQ9 RPC7_HUMAN Increases Response To Substance [124]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Response To Substance [132]
NADPH--cytochrome P450 reductase (POR) OTVIDOCH NCPR_HUMAN Increases Response To Substance [101]
Protein NDRG1 (NDRG1) OTVO66BO NDRG1_HUMAN Decreases Response To Substance [133]
Phosphoserine aminotransferase (PSAT1) OTVV1YV9 SERC_HUMAN Increases Response To Substance [124]
Uncharacterized protein C8orf34 (C8ORF34) OTXCTHDG CH034_HUMAN Increases ADR [127]
Small nuclear ribonucleoprotein F (SNRPF) OTZE5W6G RUXF_HUMAN Increases Response To Substance [124]
Adenylate kinase 2, mitochondrial (AK2) OTZG3X2H KAD2_HUMAN Increases Response To Substance [124]
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⏷ Show the Full List of 469 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Adenocarcinoma of the Gastroesophageal Junction DC0P7AH N. A. Phase 1 [134]
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100 Transcriptional activation of the carboxylesterase 2 gene by the p53 pathway. Cancer Biol Ther. 2006 Nov;5(11):1450-6.
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102 A mechanistic study on reduced toxicity of irinotecan by coadministered thalidomide, a tumor necrosis factor-alpha inhibitor. J Pharmacol Exp Ther. 2006 Oct;319(1):82-104. doi: 10.1124/jpet.106.103606. Epub 2006 Jun 30.
103 Severe toxicities after irinotecan-based chemotherapy in a patient with lung cancer: a homozygote for the SLCO1B1*15 allele. Ther Drug Monit. 2007 Oct;29(5):666-8. doi: 10.1097/FTD.0b013e3181357364.
104 Interaction of irinotecan (CPT-11) and its active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38) with human cytochrome P450 enzymes. Drug Metab Dispos. 2002 Apr;30(4):391-6.
105 5-Fluorouracil: identification of novel downstream mediators of tumour response. Anticancer Res. 2004 Mar-Apr;24(2A):417-23.
106 Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing. J Med Chem. 2011 Dec 22;54(24):8328-42. doi: 10.1021/jm2007326. Epub 2011 Nov 23.
107 Chemotherapy and TRAIL-mediated colon cancer cell death: the roles of p53, TRAIL receptors, and c-FLIP. Mol Cancer Ther. 2005 Dec;4(12):2026-36. doi: 10.1158/1535-7163.MCT-05-0262.
108 The PPAR-dependent effect of flavonoid luteolin against damage induced by the chemotherapeutic irinotecan in human intestinal cells. Chem Biol Interact. 2022 Jan 5;351:109712. doi: 10.1016/j.cbi.2021.109712. Epub 2021 Oct 23.
109 Irinotecan induces senescence and apoptosis in colonic cells in vitro. Toxicol Lett. 2012 Oct 2;214(1):1-8. doi: 10.1016/j.toxlet.2012.08.004. Epub 2012 Aug 14.
110 Ursolic and oleanolic acids in combination therapy inhibit migration of colon cancer cells through down-regulation of the uPA/uPAR-dependent MMPs pathway. Chem Biol Interact. 2022 Dec 1;368:110202. doi: 10.1016/j.cbi.2022.110202. Epub 2022 Oct 1.
111 Gefitinib ("Iressa", ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells. Cancer Chemother Pharmacol. 2005 Apr;55(4):393-403. doi: 10.1007/s00280-004-0904-0. Epub 2004 Oct 5.
112 Pharmacological targeting of NF-kappaB potentiates the effect of the topoisomerase inhibitor CPT-11 on colon cancer cells. Br J Cancer. 2008 Jan 29;98(2):335-44. doi: 10.1038/sj.bjc.6604082. Epub 2008 Jan 8.
113 The expressions of p21 and pRB may be good indicators for the sensitivity of esophageal squamous cell cancers to CPT-11: Cell proliferation activity correlates with the effect of CPT-11. Cancer Sci. 2004 May;95(5):464-8. doi: 10.1111/j.1349-7006.2004.tb03233.x.
114 Sensitization of colorectal cancer to irinotecan therapy by PARP inhibitor rucaparib. Invest New Drugs. 2019 Oct;37(5):948-960. doi: 10.1007/s10637-018-00717-9. Epub 2019 Jan 5.
115 Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N'-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells. Mol Pharmacol. 2008 Aug;74(2):517-26. doi: 10.1124/mol.107.043620. Epub 2008 May 20.
116 Effect of p53 status and STAT1 on chemotherapy-induced, Fas-mediated apoptosis in colorectal cancer. Cancer Res. 2005 Oct 1;65(19):8951-60. doi: 10.1158/0008-5472.CAN-05-0961.
117 Decreased translation of p21waf1 mRNA causes attenuated p53 signaling in some p53 wild-type tumors. Cell Cycle. 2012 May 1;11(9):1818-26. doi: 10.4161/cc.20208. Epub 2012 May 1.
118 Exogenous expression of hRFI induces multidrug resistance through escape from apoptosis in colorectal cancer cells. Anticancer Res. 2005 Jul-Aug;25(4):2737-41.
119 Enhancement of DNA topoisomerase I inhibitor-induced apoptosis by ursodeoxycholic acid. Mol Cancer Ther. 2006 Jan;5(1):68-79. doi: 10.1158/1535-7163.MCT-05-0107.
120 The histone-deacetylase inhibitor SAHA potentiates proapoptotic effects of 5-fluorouracil and irinotecan in hepatoma cells. J Cancer Res Clin Oncol. 2005 Jun;131(6):385-94. doi: 10.1007/s00432-004-0664-6. Epub 2005 Mar 8.
121 DNA topoisomerase inhibitor, etoposide, enhances GC-box-dependent promoter activity via Sp1 phosphorylation. Cancer Sci. 2007 Jun;98(6):858-63. doi: 10.1111/j.1349-7006.2007.00476.x. Epub 2007 Apr 18.
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