Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFKXDY)

Drug Name
Fenofibrate Drug Info
Synonyms
Ankebin; Antara; Controlip; Durafenat; Elasterate; Elasterin; FNF; Fenobeta; Fenobrate; Fenofanton; Fenofibrato; Fenofibratum; Fenogal; Fenoglide; Fenomax; Fenotard; Finofibrate; Fulcro; Lipanthyl; Lipantil; Liparison; Lipidex; Lipidil; Lipifen; Lipirex; Lipoclar; Lipofen; Lipofene; Liposit; Lipsin; Lofibra; Luxacor; Nolipax; Pharmavit; Phenofibrate; Procetofen; Procetofene; Proctofene; Protolipan; Secalip; Sedufen; Supralip; Tricor; Triglide; AbZ Brand of Procetofen; Abbott Brand of Procetofen; Aliud Brand of Procetofen; Antara Micronized Procetofen; Anto Brand of Procetofen; Apo Feno Micro; Apo Fenofibrate; Apotex Brand of Procetofen; Azupharma Brand of Procetofen; Betapharm Brand of Procetofen; Bouchara Brand of Procetofen; Ct Arzneimittel Brand of Procetofen; Fenofibrat AL; Fenofibrat AZU; Fenofibrat AbZ; Fenofibrat FPh; Fenofibrat Heumann; Fenofibrat Hexal; Fenofibrat Stada; Fenofibrat ratiopharm; Fenofibrat von ct; Fenofibrate Debat; Fenofibrate MSD; Fournier Brand of Procetofen; GNR Pharma Brand of Procetofen; Gate Brand of Procetofen; Gen Fenofibrate; Genpharm Brand of Procetofen; Heumann Brand of Procetofen; Hexal Brand of Procetofen; Knoll Brand of Procetofen; Lichtenstein Brand of Procetofen; Lipidil Micro; Lipidil Supra; Lipidil Ter; MTW Brand of Procetofen; MTW Fenofibrat; Merck dura Brand of Procetofen; Novartis Brand of Procetofen; Novo Fenofibrate; Novopharm Brand of Procetofen; Nu Fenofibrate; Nu Pharm Brand of Procetofen; PMS Fenofibrate Micro;Pharmascience Brand of Procetofen; Procetofen Reliant Brand; Q Pharm Brand of Procetofen; Ratiopharm Brand of Procetofen; Reliant Brand of Procetofen; Schering Plough Brand of Procetofen; Stadapharm Brand of Procetofen; United Drug Brand of Procetofen; F 6020; LF 178; LF178; AZU, Fenofibrat; Antara (TN); Antara (micronized); Apo-Fenofibrate; CIP-Fenofibrate; Ct-Arzneimittel Brand of Procetofen; Debat, Fenofibrate; FENOFIBRATE (MICRONIZED); Fenofibrat-ratiopharm; Fenofibrate IDD-P; Fenofibrate [INN:BAN]; Fenofibrato [INN-Spanish]; Fenofibratum [INN-Latin]; Fenogal (TN); GNR-Pharma Brand of Procetofen; GRS-027; Gen-Fenofibrate; Heumann, Fenofibrat; Hexal, Fenofibrat; LCP-Feno; LCP-FenoChol; LF-178; Lipanthyl (TN); Lipantil (TN); Lipidil (TN); Lipidil-Ter; Lipofen (TN); Lofibra (TN); MTW-Fenofibrat; Micronized Procetofen, Antara; Novo-Fenofibrate; Nu-Fenofibrate; Nu-Pharm Brand of Procetofen; PMS-Fenofibrate Micro; Procetofen, Antara Micronized; Q-Pharm Brand of Procetofen; Schering-Plough Brand of Procetofen; Stada, Fenofibrat; TRICOR (MICRONIZED); Tricor (TN); Triglide (TN); Trilipix (TN); Apo-Feno-Micro; Fenocor-67 (TN); Fenofibrate (JAN/INN); Isopropyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate; Isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropionate; Isopropyl 2-(p-(p-chlorobenzoyl)phenoxy)-2-methylpropionate
Indication
Disease Entry ICD 11 Status REF
Coronary atherosclerosis Approved [1]
High cholesterol level 5C80.0 Approved [2]
Hypercholesterolaemia 5C80.0 Approved [1]
Hyperlipidemia 5C80.Z Approved [1]
Hyperlipidemia, familial combined, LPL related Approved [1]
Hypertriglyceridemia 5C80.1 Approved [1]
Obesity 5B81 Approved [1]
Therapeutic Class
Antilipemic Agents
Cross-matching ID
PubChem CID
3339
ChEBI ID
CHEBI:5001
CAS Number
CAS 49562-28-9
TTD Drug ID
DMFKXDY
VARIDT Drug ID
DR00415
INTEDE Drug ID
DR0688
ACDINA Drug ID
D00268

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Peroxisome proliferator-activated receptor alpha (PPARA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lobeglitazone DMHY3IP Type-2 diabetes 5A11 Approved [10]
Bezafibrate DMZDCS0 Hypercholesterolaemia 5C80.0 Approved [11]
Ciprofibrate DMGC5DB Hyperlipoproteinemia 5C80 Approved [3]
Pemafibrate DMD1VZL Hyperlipidemia 5C80.Z Approved [12]
MURAGLITAZAR DMG3NFZ N. A. N. A. Phase 3 [13]
Ragaglitazar DMFSHEM Type-1 diabetes 5A10 Phase 3 [14]
CS-038 DM67P0F Type-2 diabetes 5A11 Phase 3 [15]
TESAGLITAZAR DMGRBN5 Type-1 diabetes 5A10 Phase 3 [16]
GFT-505 DM7ZOAE Non-alcoholic steatohepatitis DB92.1 Phase 3 [17]
ZYH-1 DMMBJYC Lipid metabolism disorder 5C52.Z Phase 3 [18]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [19]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [20]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [21]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [22]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [23]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [24]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [25]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [26]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [20]
Verapamil DMA7PEW Angina pectoris BA40 Approved [27]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A9 (UGT1A9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [28]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [29]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [31]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [27]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [27]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [32]
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [27]
Haloperidol DM96SE0 Delirium Approved [27]
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Drug(s) Affected By C-reactive protein (CRP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [33]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [34]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [35]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Acalabrutinib DM7GCVW leukaemia 2A60-2B33 Approved [38]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [39]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [40]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [41]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
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Drug(s) Affected By Serum paraoxonase/arylesterase 1 (PON1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [45]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [46]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [47]
Quercetin DM3NC4M Obesity 5B81 Approved [48]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [50]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [51]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [43]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [55]
Gefitinib DM15F0X Colon adenocarcinoma Approved [56]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Selenium DM25CGV N. A. N. A. Approved [59]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [60]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [61]
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Drug(s) Affected By S-adenosylmethionine synthase isoform type-2 (MAT2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Methotrexate DM2TEOL Anterior urethra cancer Approved [64]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [67]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Ethanol DMDRQZU Chronic pain MG30 Approved [70]
Folic Acid DMEMBJC Colorectal carcinoma Approved [64]
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Drug(s) Affected By Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [71]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [76]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Clozapine DMFC71L Schizophrenia 6A20 Approved [62]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [7]
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Drug(s) Affected By Acyl-CoA (FADS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Testosterone DM7HUNW Hot flushes GA30 Approved [79]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [79]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [80]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [81]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [82]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [84]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [85]
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Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [88]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [89]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [90]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [80]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [91]
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Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [92]
Verapamil DMA7PEW Angina pectoris BA40 Approved [93]
Methysergide DM1EF73 Migraine 8A80 Approved [94]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [95]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [94]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [96]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [97]
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Drug(s) Affected By Cytochrome P450 3A7 (CYP3A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [98]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [100]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [101]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [102]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [103]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [104]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [105]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [106]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
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Drug(s) Affected By Nitric oxide synthase 3 (NOS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [107]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [108]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [33]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Methotrexate DM2TEOL Anterior urethra cancer Approved [95]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [110]
Quercetin DM3NC4M Obesity 5B81 Approved [111]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [112]
Fructose DM43AN2 Vomiting MD90 Approved [113]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [114]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [115]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [116]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [116]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [117]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [115]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [116]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [94]
Gefitinib DM15F0X Colon adenocarcinoma Approved [115]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [118]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [115]
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Drug(s) Affected By Isocitrate dehydrogenase subunit beta, mitochondrial (IDH3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [119]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [120]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [59]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [121]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [122]
3R14S-OCHRATOXIN A DM2KEW6 Discovery agent N.A. Investigative [123]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [124]
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Drug(s) Affected By Apolipoprotein C-III (APOC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [125]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [125]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [125]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [125]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Allopurinol DMLPAOB Gout FA25 Approved [125]
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Drug(s) Affected By Lipoprotein lipase (LPL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [33]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [127]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [129]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [131]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [133]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [134]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [133]
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Drug(s) Affected By Fatty acid-binding protein, liver (FABP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [135]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [136]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [135]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [135]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Fluoxetine DM3PD2C Bipolar depression Approved [135]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [96]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [137]
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Drug(s) Affected By 3-ketoacyl-CoA thiolase, peroxisomal (ACAA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [139]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [140]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [141]
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Drug(s) Affected By Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [143]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [144]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [145]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [139]
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Drug(s) Affected By Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [146]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [131]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [147]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [148]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Menthol DMG2KW7 Back pain ME84.Z Approved [149]
Arsenic DMTL2Y1 N. A. N. A. Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [151]
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Drug(s) Affected By Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [152]
Haloperidol DM96SE0 Delirium Approved [62]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [153]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [154]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [153]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
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Drug(s) Affected By Enoyl-CoA hydratase, mitochondrial (ECHS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [155]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [156]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Arsenic DMTL2Y1 N. A. N. A. Approved [157]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [151]
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Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 1 (ACSL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [158]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [159]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [160]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphoglucomutase-1 (PGM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [75]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [162]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [163]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Haloperidol DM96SE0 Delirium Approved [62]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [67]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [165]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Succinate--CoA ligase subunit alpha, mitochondrial (SUCLG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Benzatropine DMF7EXL Parkinsonian disorder Approved [62]
Clozapine DMFC71L Schizophrenia 6A20 Approved [62]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Arsenic DMTL2Y1 N. A. N. A. Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [151]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [166]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [166]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Trifunctional enzyme subunit beta, mitochondrial (HADHB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Benzatropine DMF7EXL Parkinsonian disorder Approved [62]
Clozapine DMFC71L Schizophrenia 6A20 Approved [62]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [7]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [140]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [167]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [168]
SB-431542 DM0YOXQ Pulmonary fibrosis CB03.4 Preclinical [169]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase , mitochondrial (ALDH6A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [170]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [171]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [172]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [171]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [173]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [174]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [175]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [125]
Quercetin DM3NC4M Obesity 5B81 Approved [176]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [177]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [178]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [81]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Ciprofibrate DMGC5DB Hyperlipoproteinemia 5C80 Approved [180]
Capsaicin DMGMF6V Back pain ME84.Z Approved [181]
Sodium Acetate Anhydrous DMH21E0 Hyponatraemia 5C72 Approved [182]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [183]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [148]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [156]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [154]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [82]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Long-chain fatty acid transport protein 4 (SLC27A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Vitamin B3 DMQVRZH Chronic renal failure GB61.Z Approved [184]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [139]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [185]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [186]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [187]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [188]
Milchsaure DM462BT Pruritus EC90 Investigative [189]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aconitate hydratase, mitochondrial (ACO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [59]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [154]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [63]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [120]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [190]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [167]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [59]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [191]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [127]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [192]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [193]
Methotrexate DM2TEOL Anterior urethra cancer Approved [194]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [195]
Quercetin DM3NC4M Obesity 5B81 Approved [196]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCN family member 1 (CCN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [197]
Methotrexate DM2TEOL Anterior urethra cancer Approved [198]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [199]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [200]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [198]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [201]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [144]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Krueppel-like factor 11 (KLF11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [202]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [148]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [144]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [203]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [85]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Long-chain fatty acid transport protein 2 (SLC27A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [204]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [205]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [152]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [206]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription intermediary factor 1-alpha (TRIM24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [144]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Arsenic DMTL2Y1 N. A. N. A. Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [185]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [167]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [207]
Fluoxetine DM3PD2C Bipolar depression Approved [208]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [177]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [72]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [209]
Testosterone DM7HUNW Hot flushes GA30 Approved [79]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-1 receptor-associated kinase-like 2 (IRAK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [200]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [144]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [162]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [210]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [211]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proline dehydrogenase 1, mitochondrial (PRODH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Testosterone DM7HUNW Hot flushes GA30 Approved [79]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [79]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [212]
Menthol DMG2KW7 Back pain ME84.Z Approved [213]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [214]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [215]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aquaporin-9 (AQP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [216]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [162]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [217]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [218]
Arsenic DMTL2Y1 N. A. N. A. Approved [219]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [185]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [220]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [216]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By LYR motif-containing protein 1 (LYRM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [154]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Arsenic DMTL2Y1 N. A. N. A. Approved [150]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [76]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [121]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [122]
Milchsaure DM462BT Pruritus EC90 Investigative [189]
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Drug(s) Affected By Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [204]
Testosterone DM7HUNW Hot flushes GA30 Approved [79]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [79]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [81]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [6]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Perilipin-1 (PLIN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [7]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [82]
Arsenic DMTL2Y1 N. A. N. A. Approved [221]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [220]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [121]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [222]
OLEIC ACID DM54O1Z Discovery agent N.A. Investigative [223]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [224]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxisomal membrane protein 11A (PEX11A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [7]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [154]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [151]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [225]
Methotrexate DM2TEOL Anterior urethra cancer Approved [166]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 21 (TNFRSF21)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [170]
Methotrexate DM2TEOL Anterior urethra cancer Approved [226]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [200]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [227]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [228]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [144]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (GCAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [67]
Testosterone enanthate DMB6871 N. A. N. A. Approved [229]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [120]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [167]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [230]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [230]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alcohol dehydrogenase 1C (ADH1C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [231]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [97]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [97]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [155]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [117]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [33]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [185]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [232]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [233]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [234]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [235]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [236]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [237]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [238]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By L-lactate dehydrogenase B chain (LDHB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [239]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [80]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [240]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [82]
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Drug(s) Affected By Galactose-1-phosphate uridylyltransferase (GALT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [241]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [241]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [151]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [167]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [65]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [243]
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Drug(s) Affected By All-trans-retinol dehydrogenase ADH4 (ADH4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [7]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [117]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [244]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [151]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [99]
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Drug(s) Affected By Monocyte differentiation antigen CD14 (CD14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [245]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [200]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [246]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [152]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [247]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [248]
Testosterone DM7HUNW Hot flushes GA30 Approved [79]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [249]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
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Drug(s) Affected By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [250]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [251]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [250]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [251]
Sulfinpyrazone DMEV954 Gout FA25 Approved [252]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [250]
Zafirlukast DMHNQOG Asthma CA23 Approved [250]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [250]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [253]
Dabrafenib DMX6OE3 Melanoma 2C30 Approved [254]
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Drug(s) Affected By Electron transfer flavoprotein subunit alpha, mitochondrial (ETFA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [152]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [151]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [167]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [255]
Napabucasin DMDZ6Q3 Colorectal cancer 2B91.Z Phase 3 [256]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [243]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [122]
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Drug(s) Affected By NADPH--cytochrome P450 reductase (POR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [167]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [257]
Selenium DM25CGV N. A. N. A. Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [258]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [259]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [209]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
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Drug(s) Affected By Platelet glycoprotein 4 (CD36)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [260]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [261]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [160]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [262]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [67]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [263]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [81]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [264]
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Drug(s) Affected By Fumarylacetoacetase (FAH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [214]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [154]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [265]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [85]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [151]
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Drug(s) Affected By Arylacetamide deacetylase (AADAC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [266]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [7]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [151]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [99]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [267]
Rifapentine DMCHV4I Pulmonary tuberculosis 1B10.Z Approved [267]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [268]
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Drug(s) Affected By Plasma membrane calcium-transporting ATPase 4 (ATP2B4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [59]
Methotrexate DM2TEOL Anterior urethra cancer Approved [226]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [148]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [67]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [162]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [7]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [154]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [82]
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Drug(s) Affected By Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [269]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [270]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [81]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [198]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [198]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [178]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [98]
Testosterone DM7HUNW Hot flushes GA30 Approved [271]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [272]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [273]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [271]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pyruvate kinase PKLR (PKLR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [274]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [275]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [7]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [117]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [276]
Arsenic DMTL2Y1 N. A. N. A. Approved [150]
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Drug(s) Affected By Glycerol kinase (GK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [277]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [81]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [203]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [278]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [279]
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Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [280]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [281]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [282]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [283]
Capsaicin DMGMF6V Back pain ME84.Z Approved [284]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [285]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [286]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [285]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [281]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [33]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [287]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [288]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [289]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [290]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glucose-6-phosphatase catalytic subunit 1 (G6PC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Fluoxetine DM3PD2C Bipolar depression Approved [291]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [288]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [290]
Leflunomide DMR8ONJ Arthritis FA20 Approved [292]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [7]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [117]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [293]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Trifunctional enzyme subunit alpha, mitochondrial (HADHA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [59]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Testosterone enanthate DMB6871 N. A. N. A. Approved [229]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [294]
Bortezomib DMNO38U Leukemia Approved [203]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [59]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [295]
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Drug(s) Affected By 3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [59]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [202]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [155]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
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Drug(s) Affected By Tryptophan 2,3-dioxygenase (TDO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [296]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [273]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [162]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [297]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [298]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [99]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [299]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [300]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [301]
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Drug(s) Affected By Flavin-containing monooxygenase 5 (FMO5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [259]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [302]
Testosterone DM7HUNW Hot flushes GA30 Approved [79]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [79]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [7]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [303]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
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Drug(s) Affected By Peroxisomal multifunctional enzyme type 2 (HSD17B4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estrone DM5T6US Acne vulgaris ED80 Approved [304]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [304]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [147]
Haloperidol DM96SE0 Delirium Approved [62]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [76]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
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Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMGCS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Liothyronine DM6IR3P Congenital hypothyroidism Approved [305]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [81]
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [306]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [63]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [151]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [99]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [307]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [308]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
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Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [309]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [310]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [310]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [98]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [98]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [310]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [310]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [310]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein kinase Mer (MERTK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Testosterone DM7HUNW Hot flushes GA30 Approved [79]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [79]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [311]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [241]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [85]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [151]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [225]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [167]
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Drug(s) Affected By Krueppel-like factor 10 (KLF10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [170]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [148]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [67]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [298]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [312]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [85]
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Drug(s) Affected By Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [198]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Testosterone DM7HUNW Hot flushes GA30 Approved [313]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [314]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [162]
Paclitaxel DMLB81S Breast carcinoma Approved [315]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [198]
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Drug(s) Affected By Glycine N-methyltransferase (GNMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Testosterone DM7HUNW Hot flushes GA30 Approved [79]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [79]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Ethanol DMDRQZU Chronic pain MG30 Approved [316]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [317]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [85]
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Drug(s) Affected By Metabotropic glutamate receptor 3 (GRM3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [49]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [300]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [121]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [158]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [318]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE DMNQL17 Discovery agent N.A. Investigative [319]
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Drug(s) Affected By Hepatic sodium/bile acid cotransporter (SLC10A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [87]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [320]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [321]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [322]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [323]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [324]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [325]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
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Drug(s) Affected By Monocyte to macrophage differentiation factor (MMD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [170]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [144]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [67]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [214]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [241]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 2'-5'-oligoadenylate synthase-like protein (OASL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [198]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [326]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [327]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [328]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [154]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [82]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [198]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myosin light chain kinase, smooth muscle (MYLK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [329]
Testosterone DM7HUNW Hot flushes GA30 Approved [79]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [330]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [79]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETFDH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [154]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Arsenic DMTL2Y1 N. A. N. A. Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [331]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [167]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Laminin subunit alpha-4 (LAMA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [200]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [332]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [80]
Testosterone enanthate DMB6871 N. A. N. A. Approved [229]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [314]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [7]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [211]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By kinase isozyme 4, mitochondrial (PDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [196]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [333]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [334]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [335]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Testosterone enanthate DMB6871 N. A. N. A. Approved [229]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phospholipase A1 member A (PLA1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [162]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [211]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [151]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [121]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [162]
GW7647 DM9RD0C Discovery agent N.A. Investigative [336]
bilirubin DMI0V4O Discovery agent N.A. Investigative [337]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Protein LBH (LBH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [144]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [162]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [211]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [173]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [338]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NEDD4-binding protein 2-like 1 (N4BP2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [202]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [203]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [173]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [241]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [85]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 4A22 (CYP4A22)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [243]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [158]
Drug(s) Affected By Protein FAM222A (FAM222A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [67]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [151]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [186]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [167]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [300]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By PI-PLC X domain-containing protein 3 (PLCXD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [76]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [151]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [76]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [300]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [121]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [122]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [318]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ampicillin DMHWE7P Acute epiglottitis Approved [75]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [185]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [99]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lysophospholipid acyltransferase 5 (LPCAT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [154]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [82]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [85]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [151]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [99]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier family 25 member 34 (SLC25A34)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [205]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Arsenic DMTL2Y1 N. A. N. A. Approved [150]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [121]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [339]
Drug(s) Affected By Leucine-rich repeat-containing protein 31 (LRRC31)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [151]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [99]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [340]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [121]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [158]
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Drug(s) Affected By Lysophosphatidylcholine acyltransferase 2 (LPCAT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [154]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [139]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [167]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [230]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [300]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [230]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [121]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [122]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Monocarboxylate transporter 13 (SLC16A13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [151]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [121]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [122]
QUERCITRIN DM1DH96 Discovery agent N.A. Investigative [341]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [342]
Drug(s) Affected By Target of Nesh-SH3 (ABI3BP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [343]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [318]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [211]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [154]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [344]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [167]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [300]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [121]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-protein kinase 2 (ALPK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Testosterone DM7HUNW Hot flushes GA30 Approved [79]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [79]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [67]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [162]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [317]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [211]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [338]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 4-hydroxy-2-oxoglutarate aldolase, mitochondrial (HOGA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [76]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [173]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [85]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [230]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [121]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [122]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sphingosine-1-phosphate transporter SPNS2 (SPNS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [80]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [186]
Sphingosine-1-phosphate DMJCQKA Acne vulgaris ED80 Phase 1 [345]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [346]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [243]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [122]
Milchsaure DM462BT Pruritus EC90 Investigative [189]
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Drug(s) Affected By Cyclin-dependent kinase 20 (CDK20)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [347]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [167]
Ethanol DMDRQZU Chronic pain MG30 Approved [348]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [349]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [350]
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Drug(s) Affected By Cytochrome P450 4X1 (CYP4X1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [206]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Folic Acid DMEMBJC Colorectal carcinoma Approved [351]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [151]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [99]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [308]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [76]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [49]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Uncharacterized protein FAM241A (FAM241A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [311]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [352]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [154]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [82]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [353]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [85]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium-dependent lysophosphatidylcholine symporter 1 (MFSD2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [158]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [148]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [144]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [7]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [355]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [151]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pantothenate kinase 1 (PANK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [6]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [211]
Adefovir Dipivoxil DMMAWY1 Hepatitis B virus infection 1E51.0 Approved [6]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thyroid hormone-inducible hepatic protein (THRSP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [356]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [7]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [357]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [357]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [185]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [99]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon regulatory factor 7 (IRF7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [198]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [358]
Testosterone DM7HUNW Hot flushes GA30 Approved [79]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [79]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [359]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [198]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [198]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-modifying factor (BMF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Panobinostat DM58WKG Chronic graft versus host disease Approved [360]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [361]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [362]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [67]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [363]
Menthol DMG2KW7 Back pain ME84.Z Approved [213]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [211]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Membrane-spanning 4-domains subfamily A member 10 (MS4A10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [7]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [243]
Drug(s) Affected By Perilipin-2 (PLIN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [364]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [365]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [366]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [81]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 13 (CCL13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prednisone DM2HG4X Acute asthma CA23 Approved [367]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [287]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [214]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [368]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [121]
EUGENOL DM7US1H Discovery agent N.A. Patented [369]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [368]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Ion channel TACAN (TMEM120A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [273]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [154]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [294]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [370]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [99]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [122]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [124]
Milchsaure DM462BT Pruritus EC90 Investigative [189]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Angiopoietin-related protein 4 (ANGPTL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [33]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [200]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [80]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [81]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alanine--glyoxylate aminotransferase 2, mitochondrial (AGXT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [7]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [185]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [99]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [121]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [371]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By cAMP-dependent protein kinase inhibitor beta (PKIB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [343]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [80]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [211]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [154]
Arsenic DMTL2Y1 N. A. N. A. Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [372]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [186]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Potassium channel subfamily K member 13 (KCNK13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [173]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [372]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [300]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [121]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [122]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase Sgk2 (SGK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [373]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [314]
Ampicillin DMHWE7P Acute epiglottitis Approved [75]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [85]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sodium Acetate Anhydrous DMH21E0 Hyponatraemia 5C72 Approved [182]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Fluoxetine DM3PD2C Bipolar depression Approved [208]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [374]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [211]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein C19orf12 (C19ORF12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [82]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Arsenic DMTL2Y1 N. A. N. A. Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [185]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [349]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [243]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [122]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [124]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ethanolamine kinase 2 (ETNK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [151]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [144]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [273]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [7]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [99]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [167]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [375]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [375]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylethanolamine N-methyltransferase (PEMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [67]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [76]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [214]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [140]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [344]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [167]
Arsenic DMTL2Y1 N. A. N. A. Approved [376]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By SH3 domain-binding glutamic acid-rich-like protein 2 (SH3BGRL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [294]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [151]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [121]
Milchsaure DM462BT Pruritus EC90 Investigative [189]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Excitatory amino acid transporter 5 (SLC1A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [148]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Folic Acid DMEMBJC Colorectal carcinoma Approved [351]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [6]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [6]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [377]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [121]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [371]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Podocalyxin (PODXL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Testosterone DM7HUNW Hot flushes GA30 Approved [79]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [79]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [6]
Folic Acid DMEMBJC Colorectal carcinoma Approved [378]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Class E basic helix-loop-helix protein 40 (BHLHE40)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [266]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [379]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [380]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [202]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [269]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [381]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [191]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [382]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [383]
Selenium DM25CGV N. A. N. A. Approved [384]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [269]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [385]
Methotrexate DM2TEOL Anterior urethra cancer Approved [95]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [385]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [386]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Haloperidol DM96SE0 Delirium Approved [62]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [214]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor MafG (MAFG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [387]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [197]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [322]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [91]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By D-3-phosphoglycerate dehydrogenase (PHGDH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [198]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [200]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [198]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TP53-regulated inhibitor of apoptosis 1 (TRIAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [269]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [148]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [67]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [6]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [388]
Adefovir Dipivoxil DMMAWY1 Hepatitis B virus infection 1E51.0 Approved [6]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NUAK family SNF1-like kinase 1 (NUAK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [158]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [6]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [296]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [245]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [383]
Methotrexate DM2TEOL Anterior urethra cancer Approved [266]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [200]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [152]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [389]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [390]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier organic anion transporter family member 2B1 (SLCO2B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [204]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [205]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [391]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [343]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [76]
Ethanol DMDRQZU Chronic pain MG30 Approved [392]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [379]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [393]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [90]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [144]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [394]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [395]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [396]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [397]
Paclitaxel DMLB81S Breast carcinoma Approved [398]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [399]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [400]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [401]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [402]
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Drug(s) Affected By Alpha-enolase (ENO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [403]
Etretinate DM2CZFA Keratosis ED56 Approved [404]
Methotrexate DM2TEOL Anterior urethra cancer Approved [405]
Quercetin DM3NC4M Obesity 5B81 Approved [406]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [171]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [407]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [408]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bifunctional glutamate/proline--tRNA ligase (EPRS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Testosterone enanthate DMB6871 N. A. N. A. Approved [229]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [6]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [59]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [71]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [200]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [204]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [409]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [171]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [409]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [148]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Asparagine synthetase (ASNS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [296]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [135]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [410]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [135]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [198]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [137]
Fluoxetine DM3PD2C Bipolar depression Approved [135]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [200]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [411]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [296]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [412]
Verapamil DMA7PEW Angina pectoris BA40 Approved [413]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [414]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [415]
Selenium DM25CGV N. A. N. A. Approved [416]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [417]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [418]
Methotrexate DM2TEOL Anterior urethra cancer Approved [226]
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Drug(s) Affected By RNA-binding protein RO60 (RO60)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [175]
Selenium DM25CGV N. A. N. A. Approved [59]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [6]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Epanova DMHEAGL Hypertriglyceridemia 5C80.1 Approved [419]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinoic acid receptor alpha (RARA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [420]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [127]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [421]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [422]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [363]
Ethanol DMDRQZU Chronic pain MG30 Approved [423]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H1.2 (H1-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [170]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [200]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [80]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [296]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [197]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [360]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [199]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [424]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [171]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [245]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [382]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [425]
Selenium DM25CGV N. A. N. A. Approved [59]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [71]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [426]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [427]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [322]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [428]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [159]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor E3 (TFE3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [209]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [154]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [303]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [139]
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Drug(s) Affected By Retinoic acid receptor RXR-alpha (RXRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [429]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Selenium DM25CGV N. A. N. A. Approved [430]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [431]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [432]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [433]
Acitretin DM8BKU9 Psoriasis vulgaris EA90 Approved [434]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [435]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By B-cell lymphoma 3 protein (BCL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [436]
Selenium DM25CGV N. A. N. A. Approved [59]
Methotrexate DM2TEOL Anterior urethra cancer Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [437]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Menthol DMG2KW7 Back pain ME84.Z Approved [213]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [173]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [420]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [197]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [438]
Methotrexate DM2TEOL Anterior urethra cancer Approved [439]
Epinephrine DM3KJBC Acute asthma CA23 Approved [440]
Quercetin DM3NC4M Obesity 5B81 Approved [176]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [441]
Fructose DM43AN2 Vomiting MD90 Approved [442]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [420]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [409]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ETS domain-containing protein Elk-4 (ELK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [443]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [67]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [6]
Folic Acid DMEMBJC Colorectal carcinoma Approved [351]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By High affinity cationic amino acid transporter 1 (SLC7A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [71]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [365]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [171]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [144]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cystathionine gamma-lyase (CTH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [296]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [207]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [171]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [361]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [296]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [296]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [444]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [245]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [382]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [125]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [197]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [445]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [446]
Methotrexate DM2TEOL Anterior urethra cancer Approved [266]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aryl hydrocarbon receptor (AHR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [127]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [447]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [448]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [449]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [450]
Quercetin DM3NC4M Obesity 5B81 Approved [451]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [452]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [453]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [51]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glycine--tRNA ligase (GARS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [454]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [455]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [408]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [6]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Isoleucine--tRNA ligase, cytoplasmic (IARS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [71]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [408]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
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Drug(s) Affected By Eukaryotic translation initiation factor 1 (EIF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [456]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [390]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [6]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [457]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [162]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium- and chloride-dependent glycine transporter 1 (SLC6A9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [387]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [205]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [374]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [6]
Adefovir Dipivoxil DMMAWY1 Hepatitis B virus infection 1E51.0 Approved [6]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [82]
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Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [387]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [170]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [458]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [171]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [459]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [460]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [461]
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Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [462]
Diazepam DM08E9O Alcohol withdrawal Approved [463]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [197]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [464]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [462]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [393]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [462]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [407]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [207]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [6]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [162]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [154]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
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Drug(s) Affected By Serine/threonine-protein kinase SIK1 (SIK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [314]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [6]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [355]
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Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [465]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [425]
Selenium DM25CGV N. A. N. A. Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [365]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [204]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [459]
Estrone DM5T6US Acne vulgaris ED80 Approved [465]
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Drug(s) Affected By 1,4-alpha-glucan-branching enzyme (GBE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [466]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [67]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [82]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
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Drug(s) Affected By Adenylate cyclase type 1 (ADCY1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [33]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [6]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [467]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [85]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [468]
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Drug(s) Affected By Ras-related protein Rab-31 (RAB31)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [80]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [6]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
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Drug(s) Affected By Enhancer of filamentation 1 (NEDD9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [98]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [98]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [6]
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Drug(s) Affected By Probable E3 ubiquitin-protein ligase HERC3 (HERC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [6]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [6]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [140]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [469]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [470]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [300]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [471]
Verapamil DMA7PEW Angina pectoris BA40 Approved [413]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [245]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [472]
Selenium DM25CGV N. A. N. A. Approved [59]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [473]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [474]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [475]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [476]
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Drug(s) Affected By Cyclin-G2 (CCNG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [465]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Fluoxetine DM3PD2C Bipolar depression Approved [409]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Estrone DM5T6US Acne vulgaris ED80 Approved [465]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [144]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [67]
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Drug(s) Affected By Neuronal regeneration-related protein (NREP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [412]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [460]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [6]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [162]
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Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [477]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [478]
Prednisone DM2HG4X Acute asthma CA23 Approved [479]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [479]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [480]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [481]
Epinephrine DM3KJBC Acute asthma CA23 Approved [482]
Quercetin DM3NC4M Obesity 5B81 Approved [176]
Fluoxetine DM3PD2C Bipolar depression Approved [208]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [483]
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Drug(s) Affected By Dual specificity protein phosphatase 5 (DUSP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [484]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [383]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [485]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
Testosterone DM7HUNW Hot flushes GA30 Approved [79]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [144]
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Drug(s) Affected By Glycerol-3-phosphate acyltransferase 3 (GPAT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [318]
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Drug(s) Affected By Quinone oxidoreductase PIG3 (TP53I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [438]
Methotrexate DM2TEOL Anterior urethra cancer Approved [226]
Quercetin DM3NC4M Obesity 5B81 Approved [486]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [487]
Amifostine DM5FL14 Mucositis CA00 Approved [488]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [489]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
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Drug(s) Affected By Extracellular sulfatase Sulf-2 (SULF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [152]
Testosterone DM7HUNW Hot flushes GA30 Approved [79]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [79]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [67]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Probable ATP-dependent RNA helicase DHX37 (DHX37)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [76]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [154]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [139]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [186]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [167]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [490]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By SH3 domain and tetratricopeptide repeat-containing protein 1 (SH3TC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
Testosterone DM7HUNW Hot flushes GA30 Approved [79]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [144]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [6]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [6]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sortilin-related receptor (SORL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [318]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [6]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
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Drug(s) Affected By KICSTOR complex protein ITFG2 (ITFG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [67]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [6]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [6]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [6]
Arsenic DMTL2Y1 N. A. N. A. Approved [150]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [167]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [121]
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Drug(s) Affected By Tumor protein p53-inducible nuclear protein 1 (TP53INP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Methotrexate DM2TEOL Anterior urethra cancer Approved [226]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [491]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [492]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
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Drug(s) Affected By Protein FAM89A (FAM89A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [6]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [154]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [298]
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Drug(s) Affected By Spermatid perinuclear RNA-binding protein (STRBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [493]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [167]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [493]
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Drug(s) Affected By Growth/differentiation factor 15 (GDF15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [296]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [197]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [269]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [71]
Quercetin DM3NC4M Obesity 5B81 Approved [196]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [494]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [98]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [98]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [495]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [496]
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Drug(s) Affected By Protein orai-3 (ORAI3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [269]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [269]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [6]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [173]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
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Drug(s) Affected By Ferroptosis suppressor protein 1 (AIFM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [158]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [71]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [82]
Bortezomib DMNO38U Leukemia Approved [203]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
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Drug(s) Affected By Sulfiredoxin-1 (SRXN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [387]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [200]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [89]
Ethacrynic acid DM60QMR Edema MG29 Approved [497]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [409]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
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Drug(s) Affected By Ankyrin repeat family A protein 2 (ANKRA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Selenium DM25CGV N. A. N. A. Approved [59]
Methotrexate DM2TEOL Anterior urethra cancer Approved [266]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [6]
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Drug(s) Affected By Gephyrin (GPHN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [158]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Bortezomib DMNO38U Leukemia Approved [203]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [498]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [167]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [76]
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Drug(s) Affected By Ectonucleoside triphosphate diphosphohydrolase 7 (ENTPD7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [266]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [6]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [499]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [167]
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Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [296]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [207]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [269]
Methotrexate DM2TEOL Anterior urethra cancer Approved [364]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [500]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [171]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [152]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [492]
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Drug(s) Affected By Leucine--tRNA ligase, cytoplasmic (LARS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [175]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [154]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [6]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [230]
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Drug(s) Affected By Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [501]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [6]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [6]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [185]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [122]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [501]
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Drug(s) Affected By Bifunctional epoxide hydrolase 2 (EPHX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Selenium DM25CGV N. A. N. A. Approved [59]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [259]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [227]
Leflunomide DMR8ONJ Arthritis FA20 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Gemfibrozil DMD8Q3J Hyperlipidaemia 5C80 Approved [502]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [211]
Dihydroxyacetone DMM1LG2 Sunburn EJ40 Approved [503]
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Drug(s) Affected By Cytochrome P450 2J2 (CYP2J2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [504]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [505]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [506]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [507]
Nisoldipine DM7ISKJ Hypertension BA00-BA04 Approved [504]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Amlodipine DMBDAZV Angina pectoris BA40 Approved [504]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [273]
Gemfibrozil DMD8Q3J Hyperlipidaemia 5C80 Approved [502]
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Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [508]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [509]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Fluoxetine DM3PD2C Bipolar depression Approved [208]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [510]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [511]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [512]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [513]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [514]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [515]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [516]
Fructose DM43AN2 Vomiting MD90 Approved [33]
Ketoprofen DMRKXPT Bursitis Approved [33]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [517]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [518]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [519]
Gefitinib DM15F0X Colon adenocarcinoma Approved [520]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [521]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [128]
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Drug(s) Affected By Apolipoprotein A-I (APOA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [522]
Quercetin DM3NC4M Obesity 5B81 Approved [523]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [524]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [51]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [525]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [526]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [81]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [527]
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Drug(s) Affected By Interstitial collagenase (MMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [528]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [529]
Etretinate DM2CZFA Keratosis ED56 Approved [530]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [531]
Methotrexate DM2TEOL Anterior urethra cancer Approved [226]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [532]
Quercetin DM3NC4M Obesity 5B81 Approved [533]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [534]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [535]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [202]
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Drug(s) Affected By Apolipoprotein B-100 (APOB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [125]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [125]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [536]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [125]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [537]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [125]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [538]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [539]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [540]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [541]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [542]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [543]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [259]
Ethacrynic acid DM60QMR Edema MG29 Approved [544]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [545]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [546]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [547]
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Drug(s) Affected By 72 kDa type IV collagenase (MMP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [529]
Selenium DM25CGV N. A. N. A. Approved [548]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [549]
Quercetin DM3NC4M Obesity 5B81 Approved [550]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [551]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [552]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [553]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [554]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [555]
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Drug(s) Affected By Matrilysin (MMP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [226]
Quercetin DM3NC4M Obesity 5B81 Approved [556]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [557]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [343]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [558]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [559]
Clozapine DMFC71L Schizophrenia 6A20 Approved [560]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [214]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [561]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [562]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [563]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [564]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [33]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [484]
Verapamil DMA7PEW Angina pectoris BA40 Approved [565]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [566]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [518]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [484]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [567]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [175]
Selenium DM25CGV N. A. N. A. Approved [568]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [569]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [570]
Meloxicam DM2AR7L Arthritis FA20 Approved [571]
Methotrexate DM2TEOL Anterior urethra cancer Approved [226]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [199]
Epinephrine DM3KJBC Acute asthma CA23 Approved [482]
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Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [572]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [127]
Gefitinib DM15F0X Colon adenocarcinoma Approved [520]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [128]
Selenium DM25CGV N. A. N. A. Approved [548]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [573]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [574]
Methotrexate DM2TEOL Anterior urethra cancer Approved [575]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [576]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [577]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [578]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [579]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [365]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [178]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [578]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [580]
Capsaicin DMGMF6V Back pain ME84.Z Approved [181]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [581]
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Drug(s) Affected By Polyunsaturated fatty acid lipoxygenase ALOX12 (ALOX12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [582]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [144]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [582]
Bortezomib DMNO38U Leukemia Approved [583]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [582]
BAICALEIN DM4C7E6 Influenza virus infection 1E30-1E32 Phase 2 [582]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [584]
Milchsaure DM462BT Pruritus EC90 Investigative [189]
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Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [411]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [496]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [245]
Gefitinib DM15F0X Colon adenocarcinoma Approved [454]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [425]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [585]
Methotrexate DM2TEOL Anterior urethra cancer Approved [586]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [587]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [588]
Quercetin DM3NC4M Obesity 5B81 Approved [589]
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Drug(s) Affected By Cytochrome P450 7A1 (CYP7A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [590]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [95]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [591]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [320]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [259]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [592]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [322]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [593]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [591]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 5 (CD40)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [191]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [594]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [595]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [134]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [596]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [594]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [162]
Menthol DMG2KW7 Back pain ME84.Z Approved [213]
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Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [33]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [597]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [191]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [414]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [415]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [598]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [599]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [600]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [601]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD40 ligand (CD40LG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [128]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [595]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [261]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [602]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [264]
Menthol DMG2KW7 Back pain ME84.Z Approved [213]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [603]
Eptifibatide DMQXTJS Acute cardiac ischemic events BA40.Z Approved [604]
Candesartan DMRK8OT Chronic heart failure BD1Z Approved [605]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [606]
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Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [607]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [233]
Quercetin DM3NC4M Obesity 5B81 Approved [608]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [579]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [609]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [610]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [441]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [611]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [612]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [613]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [614]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [615]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [397]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [616]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [617]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [618]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [619]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [620]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [597]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [621]
Gefitinib DM15F0X Colon adenocarcinoma Approved [56]
Prednisone DM2HG4X Acute asthma CA23 Approved [622]
Methotrexate DM2TEOL Anterior urethra cancer Approved [623]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [624]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [625]
Quercetin DM3NC4M Obesity 5B81 Approved [626]
Fluoxetine DM3PD2C Bipolar depression Approved [627]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [628]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [629]
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Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [630]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [96]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [152]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [143]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [335]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [408]
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Drug(s) Affected By 5'-AMP-activated protein kinase subunit gamma-1 (PRKAG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [631]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [85]
Arsenic DMTL2Y1 N. A. N. A. Approved [150]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [167]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [632]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [633]
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Drug(s) Affected By Oxysterols receptor LXR-beta (NR1H2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [634]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [635]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Gemfibrozil DMD8Q3J Hyperlipidaemia 5C80 Approved [636]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [117]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [154]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [636]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [637]
Arsenic DMTL2Y1 N. A. N. A. Approved [638]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caveolin-1 (CAV1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [127]
Gefitinib DM15F0X Colon adenocarcinoma Approved [639]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [640]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [641]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [642]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [460]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [330]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxisome proliferator-activated receptor delta (PPARD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [387]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [643]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [644]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [645]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [646]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [81]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [400]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [647]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [438]
Selenium DM25CGV N. A. N. A. Approved [59]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [648]
Methotrexate DM2TEOL Anterior urethra cancer Approved [226]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [649]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [650]
Quercetin DM3NC4M Obesity 5B81 Approved [589]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [259]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Platelet-activating factor acetylhydrolase (PLA2G7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [78]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [343]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Vitamin B3 DMQVRZH Chronic renal failure GB61.Z Approved [651]
Orlistat DMRJSP8 Obesity 5B81 Approved [652]
Nitrous oxide DMTHWBI Anxiety disorder 6B00-6B0Z Approved [653]
Arsenic DMTL2Y1 N. A. N. A. Approved [221]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [654]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [76]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Oxysterols receptor LXR-alpha (NR1H3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [365]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [81]
Gemfibrozil DMD8Q3J Hyperlipidaemia 5C80 Approved [636]
Ethanol DMDRQZU Chronic pain MG30 Approved [655]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [656]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [117]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [154]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [153]
Teniposide DMLW57T Acute lymphoblastic leukaemia 2A85 Approved [637]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [657]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [597]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [158]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [438]
Methotrexate DM2TEOL Anterior urethra cancer Approved [226]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [409]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [491]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [658]
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Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [590]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [135]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [127]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [87]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [135]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [137]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [659]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Fluoxetine DM3PD2C Bipolar depression Approved [135]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adiponectin (ADIPOQ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [660]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [660]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [661]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [287]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [660]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [662]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [663]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [660]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [133]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [645]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-related protein A1 (BCL2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [664]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [198]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [665]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [162]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [603]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [198]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [355]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [198]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [540]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [197]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [666]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [667]
Estrone DM5T6US Acne vulgaris ED80 Approved [668]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [669]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [670]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [671]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [672]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [412]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proprotein convertase subtilisin/kexin type 9 (PCSK9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [673]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [211]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [674]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [298]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [675]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Scavenger receptor class B member 1 (SCARB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [676]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [677]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [659]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [513]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [678]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [635]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [81]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [679]
Selenium DM25CGV N. A. N. A. Approved [59]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [71]
Quercetin DM3NC4M Obesity 5B81 Approved [680]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [681]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [491]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [682]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [683]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
Olaparib DM8QB1D Ovarian cancer 2C73 Approved [684]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tribbles homolog 3 (TRIB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [296]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [409]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [171]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [459]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [409]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [74]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [389]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [148]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Semaphorin-6B (SEMA6B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [685]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [173]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [298]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [85]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [300]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [187]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [121]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [122]
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Drug(s) Affected By Fibroblast growth factor 21 (FGF21)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [686]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [686]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [687]
Famotidine DMRL3AB Gastric ulcer DA60 Approved [688]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [140]
Lansoprazole DMXYLQ3 Gastric ulcer DA60 Approved [688]
Bezafibrate DMZDCS0 Hypercholesterolaemia 5C80.0 Approved [689]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [690]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 5'-AMP-activated protein kinase subunit beta-1 (PRKAB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [269]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [6]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [162]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [269]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [269]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [691]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [170]
Quercetin DM3NC4M Obesity 5B81 Approved [692]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [143]
Testosterone DM7HUNW Hot flushes GA30 Approved [693]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [694]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [69]
Capsaicin DMGMF6V Back pain ME84.Z Approved [695]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [696]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [278]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By HLA class I histocompatibility antigen, A alpha chain (HLA-A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [697]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [698]
Allopurinol DMLPAOB Gout FA25 Approved [699]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [700]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [701]
Ticlopidine DMO946V Acute coronary syndrome BA41 Approved [702]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [701]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [703]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [703]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [198]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [704]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [484]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [412]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [660]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [414]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [128]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [705]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [706]
Methotrexate DM2TEOL Anterior urethra cancer Approved [198]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Peroxisome proliferator-activated receptor alpha (PPARA) TTJ584C PPARA_HUMAN Agonist [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [4]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DE85D2P UD19_HUMAN Substrate [5]
Carboxylesterase 1 (CES1) Main DME DEB30C5 EST1_HUMAN Substrate []

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1,4-alpha-glucan-branching enzyme (GBE1) OTK2N05B GLGB_HUMAN Gene/Protein Processing [6]
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1) OTO7FJA9 DHI1_HUMAN Gene/Protein Processing [7]
2'-5'-oligoadenylate synthase-like protein (OASL) OTZ05YRP OASL_HUMAN Gene/Protein Processing [7]
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (GCAT) OT6WZPWV KBL_HUMAN Gene/Protein Processing [7]
3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) OTGLVWOP THIM_HUMAN Gene/Protein Processing [7]
3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) OTVKRET0 THIK_HUMAN Gene/Protein Processing [8]
4-hydroxy-2-oxoglutarate aldolase, mitochondrial (HOGA1) OT7XETW4 HOGA1_HUMAN Gene/Protein Processing [7]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) OT7TNF0L AAPK1_HUMAN Drug Response [9]
5'-AMP-activated protein kinase subunit beta-1 (PRKAB1) OT1OG4QZ AAKB1_HUMAN Post-Translational Modifications [9]
5'-AMP-activated protein kinase subunit gamma-1 (PRKAG1) OTW00PRY AAKG1_HUMAN Gene/Protein Processing [9]

References

1 Fenofibrate FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7186).
3 Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem. 2000 Jun 2;275(22):16638-42.
4 Clinical pharmacokinetics of fibric acid derivatives (fibrates). Clin Pharmacokinet. 1998 Feb;34(2):155-62.
5 Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8.
6 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
7 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
8 Linalool is a PPARalpha ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome. J Lipid Res. 2014 Jun;55(6):1098-110.
9 AMPK-dependent signaling modulates the suppression of invasion and migration by fenofibrate in CAL 27 oral cancer cells through NF-B pathway. Environ Toxicol. 2016 Jul;31(7):866-76. doi: 10.1002/tox.22097. Epub 2014 Dec 24.
10 Tolerability and pharmacokinetics of lobeglitazone, a novel peroxisome proliferator-activated receptor-gamma agonist, after a single oral administration in healthy female subjects. Clin Drug Investig. 2014 Jul;34(7):467-74.
11 Bezafibrate at clinically relevant doses decreases serum/liver triglycerides via down-regulation of sterol regulatory element-binding protein-1c in... Mol Pharmacol. 2009 Apr;75(4):782-92.
12 Pemafibrate: First Global Approval. Drugs. 2017 Oct;77(16):1805-1810.
13 Muraglitazar, a dual (alpha/gamma) PPAR activator: a randomized, double-blind, placebo-controlled, 24-week monotherapy trial in adult patients with... Clin Ther. 2005 Aug;27(8):1181-95.
14 Ragaglitazar: the pharmacokinetics, pharmacodynamics, and tolerability of a novel dual PPAR alpha and gamma agonist in healthy subjects and patients with type 2 diabetes. J Clin Pharmacol. 2003 Nov;43(11):1244-56.
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16 Tesaglitazar, a dual PPAR-/ agonist, hamster carcinogenicity, investigative animal and clinical studies.Toxicol Pathol.2012;40(1):18-32.
17 Dual peroxisome proliferator-activated receptor / agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects.Diabetes Care.2013 Oct;36(10):2923-30.
18 Pharmacokinetics, safety, and tolerability of saroglitazar (ZYH1), a predominantly PPARalpha agonist with moderate PPARgamma agonist activity in healthy human subjects. Clin Drug Investig. 2013 Nov;33(11):809-16.
19 Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer. 2007 Mar 1;109(5):957-65.
20 Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47.
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22 Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone. Drug Metab Dispos. 2013 Feb;41(2):263-9.
23 Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
24 Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates. Br J Pharmacol. 2012 Apr;165(8):2787-98.
25 Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos. 2007 Apr;28(3):151-6.
26 The metabolism of zidovudine by human liver microsomes in vitro: formation of 3'-amino-3'-deoxythymidine. Biochem Pharmacol. 1994 Jul 19;48(2):267-76.
27 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
28 Polymorphic expression of UGT1A9 is associated with variable acetaminophen glucuronidation in neonates: a population pharmacokinetic and pharmacogenetic study. Clin Pharmacokinet. 2018 Oct;57(10):1325-1336.
29 Glucuronidation of nonsteroidal anti-inflammatory drugs: identifying the enzymes responsible in human liver microsomes. Drug Metab Dispos. 2005 Jul;33(7):1027-35.
30 Pharmacokinetic interaction involving sorafenib and the calcium-channel blocker felodipine in a patient with hepatocellular carcinoma. Invest New Drugs. 2011 Dec;29(6):1511-4.
31 The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune disease. Clin Pharmacokinet. 2011 Jan;50(1):1-24.
32 The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene. J Biol Chem. 2003 Apr 18;278(16):13975-83.
33 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
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654 Comparative effects of raloxifene, tamoxifen and estradiol on human osteoblasts in vitro: estrogen receptor dependent or independent pathways of raloxifene. J Steroid Biochem Mol Biol. 2009 Feb;113(3-5):281-9.
655 The potential effects of HECTD4 variants on fasting glucose and triglyceride levels in relation to prevalence of type 2 diabetes based on alcohol intake. Arch Toxicol. 2022 Sep;96(9):2487-2499. doi: 10.1007/s00204-022-03325-y. Epub 2022 Jun 17.
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694 Atorvastatin and pravastatin stimulate nitric oxide and reactive oxygen species generation, affect mitochondrial network architecture and elevate nicotinamide N-methyltransferase level in endothelial cells. J Appl Toxicol. 2021 Jul;41(7):1076-1088. doi: 10.1002/jat.4094. Epub 2020 Oct 19.
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