Details of the Drug Combination

General Information of Drug Combination (ID: DCUVZQI)

• Drug Combination Name: Ethanol + Lidocaine
• Indication: Neoplasms, Cystic, Mucinous, and Serous; Status: Phase 1 [1]
• Component Drugs:
  Ethanol (DMDRQZU): Small molecular drug
  Lidocaine (DML4ZOT): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Ethanol

Disease Entry	ICD 11	Status	REF
Chronic pain	MG30	Approved	[2]
Cystic tumor of the pancreas	N.A.	Approved	[3]
Cystitis	GC00	Approved	[2]

Ethanol Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
GABA(A) receptor alpha-1 (GABRA1)	TT1MPAY	GBRA1_HUMAN	Antagonist	[15]

Ethanol Interacts with 13 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[16]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[16]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Metabolism	[17]
Cytochrome P450 2E1 (CYP2E1)	DEVDYN7	CP2E1_HUMAN	Metabolism	[18]
Alcohol dehydrogenase class-V (ADH6)	DE017IC	ADH6_HUMAN	Metabolism	[19]
Aldo-keto reductase 1A1 (AKR1A1)	DED2FW3	AK1A1_HUMAN	Metabolism	[19]
Alcohol dehydrogenase class-I alpha (ADH1A)	DEE5M8O	ADH1A_HUMAN	Metabolism	[20]
Alcohol dehydrogenase class-I beta (ADH1B)	DEEN9RD	ADH1B_HUMAN	Metabolism	[20]
Alcohol dehydrogenase class-I gamma (ADH1C)	DEM1HNL	ADH1G_HUMAN	Metabolism	[20]
Alcohol dehydrogenase class-II (ADH4)	DEOCWU3	ADH4_HUMAN	Metabolism	[21]
Gastric alcohol dehydrogenase (ADH7)	DEZMAHX	ADH7_HUMAN	Metabolism	[19]
Alcohol dehydrogenase class-III (ADH5)	DEIOH6A	ADHX_HUMAN	Metabolism	[19]
Alcohol dehydrogenase (ADH)	DEG8NJD	A0A2I1XAT4_NEISI	Metabolism	[22]

Ethanol Interacts with 576 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Increases Expression	[23]
Alcohol dehydrogenase 1A (ADH1A)	OTTS983E	ADH1A_HUMAN	Increases Expression	[24]
All-trans-retinol dehydrogenase ADH1B (ADH1B)	OTV3TB81	ADH1B_HUMAN	Increases Expression	[8]
Cytochrome P450 1A2 (CYP1A2)	OTLLBX48	CP1A2_HUMAN	Increases Expression	[25]
Alcohol dehydrogenase 1C (ADH1C)	OTO1DV7F	ADH1G_HUMAN	Increases Expression	[24]
Cytochrome P450 2E1 (CYP2E1)	OTHQ17JG	CP2E1_HUMAN	Increases Expression	[24]
Alcohol dehydrogenase class-3 (ADH5)	OTSO67MI	ADHX_HUMAN	Increases Oxidation	[26]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Decreases Phosphorylation	[27]
Serotransferrin (TF)	OT41PEMS	TRFE_HUMAN	Increases Expression	[11]
Proenkephalin-A (PENK)	OT8P3HMP	PENK_HUMAN	Decreases Expression	[28]
Glutathione S-transferase Mu 1 (GSTM1)	OTSBF2MO	GSTM1_HUMAN	Affects Response To Substance	[29]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Increases Expression	[30]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Increases Expression	[30]
Sulfotransferase 1A3 (SULT1A4)	OTHJ8WWV	ST1A3_HUMAN	Decreases Activity	[31]
Sulfotransferase 1E1 (SULT1E1)	OTGPJ517	ST1E1_HUMAN	Decreases Activity	[31]
Sulfotransferase 1A1 (SULT1A1)	OT0K7JIE	ST1A1_HUMAN	Decreases Activity	[31]
Sulfotransferase 2A1 (SULT2A1)	OT0ISKQ4	ST2A1_HUMAN	Decreases Activity	[31]
S-adenosylmethionine synthase isoform type-2 (MAT2A)	OTFJMIQR	METK2_HUMAN	Decreases Expression	[32]
Protein-glutamine gamma-glutamyltransferase 2 (TGM2)	OT6MFOWF	TGM2_HUMAN	Increases Expression	[33]
Cytochrome b-245 heavy chain (CYBB)	OTGSG868	CY24B_HUMAN	Increases Expression	[7]
Nitric oxide synthase, inducible (NOS2)	OTKKIOJ1	NOS2_HUMAN	Increases Expression	[7]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)	OTXEE550	APR_HUMAN	Increases Expression	[34]
Neurogenic locus notch homolog protein 3 (NOTCH3)	OTMVVA7F	NOTC3_HUMAN	Increases Expression	[34]
N-glycosylase/DNA lyase (OGG1)	OTJ97TF3	OGG1_HUMAN	Increases Expression	[8]
Aldehyde dehydrogenase, mitochondrial (ALDH2)	OTKJ9I3N	ALDH2_HUMAN	Increases Expression	[8]
Cytochrome P450 2A6 (CYP2A6)	OT52TWG3	CP2A6_HUMAN	Increases Expression	[35]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Decreases Activity	[36]
Intercellular adhesion molecule 1 (ICAM1)	OTTOIX77	ICAM1_HUMAN	Increases Expression	[24]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Secretion	[24]
Protein shisa-3 homolog (SHISA3)	OTE8TPCP	SHSA3_HUMAN	Increases Expression	[9]
Cytosolic acyl coenzyme A thioester hydrolase (ACOT7)	OT7C68YV	BACH_HUMAN	Decreases Expression	[9]
Left-right determination factor 2 (LEFTY2)	OT3RX4QF	LFTY2_HUMAN	Increases Expression	[9]
TNF receptor-associated factor 5 (TRAF5)	OTSBTLO0	TRAF5_HUMAN	Increases Expression	[9]
Class E basic helix-loop-helix protein 40 (BHLHE40)	OTITX14U	BHE40_HUMAN	Increases Expression	[9]
Copper chaperone for superoxide dismutase (CCS)	OTXHT3QO	CCS_HUMAN	Increases Expression	[9]
Centrin-3 (CETN3)	OTG4PL7H	CETN3_HUMAN	Decreases Expression	[9]
Histone H2B type 1-K (H2BC12)	OTQ8V0KG	H2B1K_HUMAN	Decreases Expression	[9]
Forkhead box protein H1 (FOXH1)	OTEXJ9SL	FOXH1_HUMAN	Increases Expression	[9]
Left-right determination factor 1 (LEFTY1)	OT51HVC4	LFTY1_HUMAN	Increases Expression	[9]
Protein FAM13A (FAM13A)	OTZ6GN0Q	FA13A_HUMAN	Increases Expression	[9]
Lecithin retinol acyltransferase (LRAT)	OTB7CJKY	LRAT_HUMAN	Increases Expression	[9]
Heat shock 70 kDa protein 4L (HSPA4L)	OT181WZB	HS74L_HUMAN	Increases Expression	[9]
Thy-1 membrane glycoprotein (THY1)	OTVONVTB	THY1_HUMAN	Decreases Expression	[9]
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)	OTG7J4BP	PPBT_HUMAN	Decreases Expression	[9]
Histone H2B type 1-J (H2BC11)	OTGM083T	H2B1J_HUMAN	Decreases Expression	[9]
Gamma-enolase (ENO2)	OTRODL0T	ENOG_HUMAN	Decreases Expression	[9]
Fructose-bisphosphate aldolase C (ALDOC)	OTEC13I5	ALDOC_HUMAN	Decreases Expression	[9]
Thymosin beta-15A (TMSB15A)	OTSBWCES	TB15A_HUMAN	Decreases Expression	[9]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Decreases Expression	[9]
NAD(P)H dehydrogenase 1 (NQO1)	OTZGGIVK	NQO1_HUMAN	Decreases Expression	[9]
Histone H1.2 (H1-2)	OT0AVI4M	H12_HUMAN	Decreases Expression	[9]
Heat shock 70 kDa protein 6 (HSPA6)	OTH4S7WB	HSP76_HUMAN	Increases Expression	[9]
Blood group Rh(CE) polypeptide (RHCE)	OTS18IZ5	RHCE_HUMAN	Decreases Expression	[9]
Insulin-like growth factor-binding protein 5 (IGFBP5)	OTRE5V0C	IBP5_HUMAN	Increases Expression	[9]
5-hydroxytryptamine receptor 1D (HTR1D)	OTLS74AF	5HT1D_HUMAN	Increases Expression	[9]
Protein-lysine 6-oxidase (LOX)	OT1C2HIU	LYOX_HUMAN	Increases Expression	[9]
M-phase inducer phosphatase 1 (CDC25A)	OTSLKKCO	MPIP1_HUMAN	Decreases Expression	[9]
Somatostatin receptor type 1 (SSTR1)	OTFAGWO7	SSR1_HUMAN	Increases Expression	[9]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2)	OTOB6J6R	RIR2_HUMAN	Decreases Expression	[9]
Replication factor C subunit 1 (RFC1)	OT3L5PK3	RFC1_HUMAN	Decreases Expression	[9]
Nuclear receptor ROR-alpha (RORA)	OTGQT12P	RORA_HUMAN	Increases Expression	[9]
Activin receptor type-1B (ACVR1B)	OT778HIQ	ACV1B_HUMAN	Increases Expression	[9]
Amiloride-sensitive sodium channel subunit alpha (SCNN1A)	OTE2KVZV	SCNNA_HUMAN	Increases Expression	[9]
E3 ubiquitin-protein ligase NEDD4 (NEDD4)	OTFPXLXT	NEDD4_HUMAN	Decreases Expression	[9]
Steroidogenic acute regulatory protein, mitochondrial (STAR)	OTFEZ5AI	STAR_HUMAN	Decreases Expression	[9]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 (GNG4)	OTOXNDI9	GBG4_HUMAN	Decreases Expression	[9]
Stanniocalcin-1 (STC1)	OTGVVXYF	STC1_HUMAN	Increases Expression	[9]
Homeobox protein goosecoid (GSC)	OT4DH7PR	GSC_HUMAN	Increases Expression	[9]
Small nuclear ribonucleoprotein G (SNRPG)	OTWX4XK1	RUXG_HUMAN	Decreases Expression	[9]
Histone H2B type 1-C/E/F/G/I (H2BC10)	OTLQH0D6	H2B1C_HUMAN	Decreases Expression	[9]
Mothers against decapentaplegic homolog 3 (SMAD3)	OTNA96MR	SMAD3_HUMAN	Increases Expression	[9]
Disabled homolog 2 (DAB2)	OTRMQTMZ	DAB2_HUMAN	Decreases Expression	[9]
POU domain, class 5, transcription factor 1 (POU5F1)	OTDHHN7O	PO5F1_HUMAN	Increases Expression	[9]
Mothers against decapentaplegic homolog 4 (SMAD4)	OTWQWCKG	SMAD4_HUMAN	Increases Expression	[9]
Protein patched homolog 1 (PTCH1)	OTMG07H5	PTC1_HUMAN	Increases Expression	[9]
Endogenous retrovirus group 3 member 1 Env polyprotein (ERV3-1)	OT4CW64T	ENR1_HUMAN	Increases Expression	[9]
Neuronatin (NNAT)	OTNRLO7G	NNAT_HUMAN	Decreases Expression	[9]
Cyclin-G2 (CCNG2)	OTII38K2	CCNG2_HUMAN	Increases Expression	[9]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)	OTQYEXL2	F264_HUMAN	Increases Expression	[9]
Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1)	OTN7XAUD	LRRF1_HUMAN	Decreases Expression	[9]
Leucine-rich repeat and calponin homology domain-containing protein 2 (LRCH2)	OTUEUEHY	LRCH2_HUMAN	Decreases Expression	[9]
Gliomedin (GLDN)	OTA8TQU9	GLDN_HUMAN	Increases Expression	[9]
Basic immunoglobulin-like variable motif-containing protein (BIVM)	OTQEJWSA	BIVM_HUMAN	Decreases Expression	[9]
Prolyl 3-hydroxylase 2 (P3H2)	OTY84H6U	P3H2_HUMAN	Increases Expression	[9]
Dedicator of cytokinesis protein 3 (DOCK3)	OTF3YS2W	DOCK3_HUMAN	Increases Expression	[9]
Secreted frizzled-related protein 1 (SFRP1)	OT0U9G41	SFRP1_HUMAN	Increases Expression	[9]
Kinetochore protein Spc24 (SPC24)	OT1HVYV4	SPC24_HUMAN	Decreases Expression	[9]
Olfactory receptor 5P3 (OR5P3)	OTIXMOUN	OR5P3_HUMAN	Increases Expression	[9]
Arrestin domain-containing protein 3 (ARRDC3)	OTAKW7R9	ARRD3_HUMAN	Increases Expression	[9]
Dynein axonemal heavy chain 11 (DNAH11)	OT6IYFVV	DYH11_HUMAN	Increases Expression	[9]
Cysteine and tyrosine-rich protein 1 (CYYR1)	OTKNFPUY	CYYR1_HUMAN	Decreases Expression	[9]
Histone H2A type 1-H (H2AC12)	OTLXVB97	H2A1H_HUMAN	Decreases Expression	[9]
RNA-binding protein 14 (RBM14)	OTO9GMBD	RBM14_HUMAN	Increases Expression	[9]
Nodal homolog (NODAL)	OTZ34981	NODAL_HUMAN	Increases Expression	[9]
Histone H2B type 1-M (H2BC14)	OTSDZZZY	H2B1M_HUMAN	Decreases Expression	[9]
Kelch-like protein 4 (KLHL4)	OTEFI623	KLHL4_HUMAN	Increases Expression	[9]
Class E basic helix-loop-helix protein 41 (BHLHE41)	OTY9GJ1Y	BHE41_HUMAN	Increases Expression	[9]
Egl nine homolog 1 (EGLN1)	OT5QODDK	EGLN1_HUMAN	Increases Expression	[9]
Centromere protein H (CENPH)	OTPOO9LK	CENPH_HUMAN	Decreases Expression	[9]
Thiol S-methyltransferase TMT1A (TMT1A)	OT4IAAZP	TMT1A_HUMAN	Decreases Expression	[9]
Homeobox protein NANOG (NANOG)	OTUEY1FM	NANOG_HUMAN	Increases Expression	[9]
Pleckstrin homology domain-containing family A member 2 (PLEKHA2)	OTY2AP6T	PKHA2_HUMAN	Increases Expression	[9]
Protein BEX1 (BEX1)	OTBQIF0H	BEX1_HUMAN	Decreases Expression	[9]
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM)	OTR1XD9B	GPAT1_HUMAN	Decreases Expression	[9]
Muscleblind-like protein 3 (MBNL3)	OT2T2YOK	MBNL3_HUMAN	Increases Expression	[9]
Cell growth-regulating nucleolar protein (LYAR)	OTQNA67C	LYAR_HUMAN	Decreases Expression	[9]
PTB domain-containing engulfment adapter protein 1 (GULP1)	OT1WMVDH	GULP1_HUMAN	Decreases Expression	[9]
Claudin-16 (CLDN16)	OTTHAIKR	CLD16_HUMAN	Increases Expression	[9]
Insulin-induced gene 2 protein (INSIG2)	OTX4VY51	INSI2_HUMAN	Increases Expression	[9]
Protein patched homolog 2 (PTCH2)	OTOQ0K9V	PTC2_HUMAN	Decreases Expression	[9]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Increases Expression	[37]
Glycogen synthase kinase-3 beta (GSK3B)	OTL3L14B	GSK3B_HUMAN	Increases Phosphorylation	[37]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Affects Localization	[37]
Nuclear factor of activated T-cells, cytoplasmic 3 (NFATC3)	OTYOORME	NFAC3_HUMAN	Increases Expression	[37]
Amine oxidase A (MAOA)	OT8NIWMQ	AOFA_HUMAN	Decreases Activity	[38]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Increases Phosphorylation	[23]
Mitogen-activated protein kinase 9 (MAPK9)	OTCEVJ9E	MK09_HUMAN	Increases Phosphorylation	[23]
Cytochrome P450 4F2 (CYP4F2)	OTKILAER	CP4F2_HUMAN	Decreases Expression	[23]
Cytochrome P450 4F11 (CYP4F11)	OTHZ2GG2	CP4FB_HUMAN	Increases Expression	[23]
Cytochrome P450 4F12 (CYP4F12)	OTIUY7E6	CP4FC_HUMAN	Increases Expression	[23]
Synaptophysin (SYP)	OTFJKMO4	SYPH_HUMAN	Decreases Expression	[39]
Drebrin (DBN1)	OTZVKG8A	DREB_HUMAN	Decreases Expression	[39]
Glutathione reductase, mitochondrial (GSR)	OTM2TUYM	GSHR_HUMAN	Decreases Activity	[40]
Acetylcholinesterase (ACHE)	OT2H8HG6	ACES_HUMAN	Increases Activity	[41]
Ankyrin repeat domain-containing protein 33B (ANKRD33B)	OTTO39IV	AN33B_HUMAN	Increases Expression	[10]
Elongin BC and Polycomb repressive complex 2-associated protein (EPOP)	OTOYAP3V	EPOP_HUMAN	Increases Expression	[10]
Huntingtin-interacting protein 1 (HIP1)	OT7AKCFQ	HIP1_HUMAN	Increases Expression	[10]
Homeobox protein Meis2 (MEIS2)	OTG4ADLM	MEIS2_HUMAN	Decreases Expression	[10]
Calmegin (CLGN)	OTEWVFQV	CLGN_HUMAN	Increases Expression	[10]
Glutathione S-transferase A4 (GSTA4)	OTZ1USIA	GSTA4_HUMAN	Decreases Expression	[10]
Prolyl 4-hydroxylase subunit alpha-2 (P4HA2)	OTP45YKX	P4HA2_HUMAN	Increases Expression	[10]
Calpain-5 (CAPN5)	OTQ8QM7K	CAN5_HUMAN	Increases Expression	[10]
Uncharacterized protein KIAA0513 (KIAA0513)	OT7AVTFB	K0513_HUMAN	Increases Expression	[10]
Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP)	OTRNDZXB	HNRPQ_HUMAN	Decreases Expression	[10]
Syndecan-3 (SDC3)	OT1P0LJM	SDC3_HUMAN	Increases Expression	[10]
Low-density lipoprotein receptor-related protein 4 (LRP4)	OTO4M459	LRP4_HUMAN	Increases Expression	[10]
Filamin-B (FLNB)	OTPCOYL6	FLNB_HUMAN	Increases Expression	[10]
Src kinase-associated phosphoprotein 2 (SKAP2)	OTSF44KP	SKAP2_HUMAN	Decreases Expression	[10]
Microtubule cross-linking factor 2 (MTCL2)	OTYL5HK1	MTCL2_HUMAN	Increases Expression	[10]
Ras-related protein Rab-3D (RAB3D)	OTGKRR3C	RAB3D_HUMAN	Increases Expression	[10]
L-lactate dehydrogenase A chain (LDHA)	OTN7K4XB	LDHA_HUMAN	Decreases Expression	[10]
Dihydrofolate reductase (DHFR)	OT3DVIGM	DYR_HUMAN	Decreases Expression	[10]
Phosphoglycerate kinase 1 (PGK1)	OT6V1ICH	PGK1_HUMAN	Decreases Expression	[10]
Plasma serine protease inhibitor (SERPINA5)	OTTZXPGD	IPSP_HUMAN	Increases Expression	[10]
Transcription factor AP-2-alpha (TFAP2A)	OTMYT3NK	AP2A_HUMAN	Increases Expression	[10]
Histone H1.0 (H1-0)	OTRLJK4Z	H10_HUMAN	Decreases Expression	[10]
Tumor necrosis factor receptor superfamily member 16 (NGFR)	OTPKSM49	TNR16_HUMAN	Increases Expression	[10]
Apelin receptor early endogenous ligand (APELA)	OTYY0P69	ELA_HUMAN	Decreases Expression	[10]
Retinoic acid receptor alpha (RARA)	OT192V9V	RARA_HUMAN	Increases Expression	[10]
Tissue factor pathway inhibitor (TFPI)	OTA0FX16	TFPI1_HUMAN	Decreases Expression	[10]
Retinoic acid receptor beta (RARB)	OT367U3E	RARB_HUMAN	Increases Expression	[10]
Thyroid hormone receptor beta (THRB)	OTBBIRHZ	THB_HUMAN	Increases Expression	[10]
Ornithine decarboxylase (ODC1)	OTNDAGRR	DCOR_HUMAN	Increases Expression	[10]
Protein Cripto (CRIPTO)	OT46DZXJ	TDGF1_HUMAN	Decreases Expression	[10]
Retinoic acid receptor gamma (RARG)	OT8LHMDH	RARG_HUMAN	Increases Expression	[10]
Carboxypeptidase E (CPE)	OTXNTV79	CBPE_HUMAN	Decreases Expression	[10]
Tyrosine-protein phosphatase non-receptor type 3 (PTPN3)	OTSLZBVY	PTN3_HUMAN	Increases Expression	[10]
Cystathionine beta-synthase (CBS)	OT46FSKD	CBS_HUMAN	Decreases Expression	[10]
Large ribosomal subunit protein uL13 (RPL13A)	OTME3VXN	RL13A_HUMAN	Decreases Expression	[10]
OX-2 membrane glycoprotein (CD200)	OTQEQSRT	OX2G_HUMAN	Decreases Expression	[10]
Tumor necrosis factor ligand superfamily member 9 (TNFSF9)	OTV9L89D	TNFL9_HUMAN	Decreases Expression	[10]
Chromobox protein homolog 5 (CBX5)	OT8VYY84	CBX5_HUMAN	Decreases Expression	[10]
Transcriptional regulator ATRX (ATRX)	OT77RSQW	ATRX_HUMAN	Decreases Expression	[10]
Nuclear autoantigenic sperm protein (NASP)	OTNE4THC	NASP_HUMAN	Decreases Expression	[10]
Emerin (EMD)	OTR8ZANE	EMD_HUMAN	Increases Expression	[10]
Serpin B9 (SERPINB9)	OTJ811IF	SPB9_HUMAN	Decreases Expression	[10]
Annexin A11 (ANXA11)	OT8SRY1C	ANX11_HUMAN	Increases Expression	[10]
Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3)	OT4O4NFS	ROA3_HUMAN	Decreases Expression	[10]
Mitogen-activated protein kinase 10 (MAPK10)	OTC46VX1	MK10_HUMAN	Decreases Expression	[10]
Activated RNA polymerase II transcriptional coactivator p15 (SUB1)	OTK71JYU	TCP4_HUMAN	Decreases Expression	[10]
CD81 antigen (CD81)	OTQFXNAZ	CD81_HUMAN	Increases Expression	[10]
Triosephosphate isomerase (TPI1)	OT14KP4B	TPIS_HUMAN	Decreases Expression	[10]
Myelin proteolipid protein (PLP1)	OT8CM9CX	MYPR_HUMAN	Increases Expression	[10]
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB)	OTYFTYFR	PP1B_HUMAN	Decreases Expression	[10]
Rho-related GTP-binding protein RhoB (RHOB)	OTHQFQF7	RHOB_HUMAN	Decreases Expression	[10]
Histone H4 (H4C1)	OTB71W46	H4_HUMAN	Decreases Expression	[10]
Histone H3.1 (H3C1)	OTGBGOZW	H31_HUMAN	Decreases Expression	[10]
RNA-binding protein 3 (RBM3)	OTAJ7R31	RBM3_HUMAN	Decreases Expression	[10]
Heterogeneous nuclear ribonucleoprotein U (HNRNPU)	OTLQN1E2	HNRPU_HUMAN	Decreases Expression	[10]
Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4)	OTPV1D60	FKBP4_HUMAN	Increases Expression	[10]
Peroxisome proliferator-activated receptor delta (PPARD)	OTI4WTOP	PPARD_HUMAN	Increases Expression	[10]
Activin receptor type-1 (ACVR1)	OT4JATFE	ACVR1_HUMAN	Increases Expression	[10]
Protocadherin-1 (PCDH1)	OT7KDEL3	PCDH1_HUMAN	Increases Expression	[10]
Lysyl oxidase homolog 1 (LOXL1)	OTA0NEJU	LOXL1_HUMAN	Increases Expression	[10]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)	OT4SO7J4	BNIP3_HUMAN	Decreases Expression	[10]
Serine/arginine-rich splicing factor 6 (SRSF6)	OTGLOSYE	SRSF6_HUMAN	Decreases Expression	[10]
Ribosomal protein S6 kinase alpha-2 (RPS6KA2)	OTIOYUSU	KS6A2_HUMAN	Increases Expression	[10]
Transcription initiation factor TFIID subunit 7 (TAF7)	OT43QHS3	TAF7_HUMAN	Decreases Expression	[10]
Dixin (DIXDC1)	OT87DXEG	DIXC1_HUMAN	Increases Expression	[10]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)	OT25JBA3	F263_HUMAN	Decreases Expression	[10]
Protogenin (PRTG)	OTDE8D9Z	PRTG_HUMAN	Decreases Expression	[10]
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB)	OT2Z03OB	GNPTA_HUMAN	Increases Expression	[10]
La-related protein 7 (LARP7)	OTLLOZTL	LARP7_HUMAN	Decreases Expression	[10]
Angiomotin (AMOT)	OTWHDG9B	AMOT_HUMAN	Increases Expression	[10]
Solute carrier family 35 member F1 (SLC35F1)	OTRXHR2P	S35F1_HUMAN	Increases Expression	[10]
EEIG family member 2 (EEIG2)	OTN8R8DQ	EEIG2_HUMAN	Increases Expression	[10]
Early estrogen-induced gene 1 protein (EEIG1)	OT2BMEAE	EEIG1_HUMAN	Increases Expression	[10]
Protein lin-9 homolog (LIN9)	OTLHW00C	LIN9_HUMAN	Decreases Expression	[10]
Complexin-2 (CPLX2)	OTU5QWFH	CPLX2_HUMAN	Decreases Expression	[10]
Oligodendrocyte transcription factor 3 (OLIG3)	OTU8XLAF	OLIG3_HUMAN	Decreases Expression	[10]
Monocarboxylate transporter 9 (SLC16A9)	OTVCLKQQ	MOT9_HUMAN	Increases Expression	[10]
L-xylulose reductase (DCXR)	OTYVXRXB	DCXR_HUMAN	Increases Expression	[10]
Choline transporter-like protein 2 (SLC44A2)	OT11T33C	CTL2_HUMAN	Increases Expression	[10]
E3 ubiquitin-protein ligase TRIM22 (TRIM22)	OTJBLG5R	TRI22_HUMAN	Increases Expression	[10]
Xaa-Arg dipeptidase (PM20D2)	OTD2Y7LU	P20D2_HUMAN	Increases Expression	[10]
Large neutral amino acids transporter small subunit 4 (SLC43A2)	OTMSOSOX	LAT4_HUMAN	Increases Expression	[10]
Refilin-B (RFLNB)	OTI7ZM75	RFLB_HUMAN	Increases Expression	[10]
Myc target protein 1 (MYCT1)	OTZ8A9L3	MYCT1_HUMAN	Decreases Expression	[10]
Insulin-like growth factor-binding protein-like 1 (IGFBPL1)	OTY4HVN8	IBPL1_HUMAN	Increases Expression	[10]
TBC1 domain family member 5 (TBC1D5)	OTNHLLAX	TBCD5_HUMAN	Increases Expression	[10]
Neogenin (NEO1)	OTGJ1997	NEO1_HUMAN	Increases Expression	[10]
Exostosin-like 1 (EXTL1)	OTMSNY9N	EXTL1_HUMAN	Increases Expression	[10]
Arylsulfatase G (ARSG)	OTT7TDW7	ARSG_HUMAN	Increases Expression	[10]
Protein LRATD2 (LRATD2)	OTEZBUUL	LRAT2_HUMAN	Increases Expression	[10]
Transmembrane protein 237 (TMEM237)	OTQEVL7L	TM237_HUMAN	Decreases Expression	[10]
Growth/differentiation factor 15 (GDF15)	OTWQN50N	GDF15_HUMAN	Increases Expression	[10]
La-related protein 6 (LARP6)	OTUQ9QS9	LARP6_HUMAN	Increases Expression	[10]
Acidic leucine-rich nuclear phosphoprotein 32 family member E (ANP32E)	OTTWELUQ	AN32E_HUMAN	Decreases Expression	[10]
TNF receptor-associated factor 4 (TRAF4)	OTJLRVMC	TRAF4_HUMAN	Increases Expression	[10]
RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1)	OTOOXC7B	HOIL1_HUMAN	Increases Expression	[10]
Transmembrane gamma-carboxyglutamic acid protein 4 (PRRG4)	OT2SZQI7	TMG4_HUMAN	Increases Expression	[10]
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 (NMNAT2)	OT5JLP2H	NMNA2_HUMAN	Increases Expression	[10]
Protein Niban 1 (NIBAN1)	OTYOLI12	NIBA1_HUMAN	Increases Expression	[10]
Thiamine transporter 2 (SLC19A3)	OTOWP1CT	S19A3_HUMAN	Decreases Expression	[10]
Homeobox protein Hox-D1 (HOXD1)	OTN4V9ZF	HXD1_HUMAN	Decreases Expression	[10]
Protein mono-ADP-ribosyltransferase PARP12 (PARP12)	OTCQTYIO	PAR12_HUMAN	Increases Expression	[10]
Probable E3 ubiquitin-protein ligase IRF2BPL (IRF2BPL)	OTV8MNT1	I2BPL_HUMAN	Increases Expression	[10]
Nucleoporin-62 C-terminal-like protein (NUP62CL)	OTEN1HET	N62CL_HUMAN	Increases Expression	[10]
Ras association domain-containing protein 4 (RASSF4)	OT7YLOFH	RASF4_HUMAN	Increases Expression	[10]
Olfactomedin-like protein 3 (OLFML3)	OTDN45FN	OLFL3_HUMAN	Decreases Expression	[10]
Anoctamin-10 (ANO10)	OTG3BNOU	ANO10_HUMAN	Increases Expression	[10]
Dapper homolog 1 (DACT1)	OT19Z704	DACT1_HUMAN	Decreases Expression	[10]
Bcl-2-associated transcription factor 1 (BCLAF1)	OT7T8H6A	BCLF1_HUMAN	Decreases Expression	[10]
Transcription factor CP2-like protein 1 (TFCP2L1)	OT7QIJ0X	TF2L1_HUMAN	Increases Expression	[10]
Peroxisomal sarcosine oxidase (PIPOX)	OTWTCOTN	SOX_HUMAN	Decreases Expression	[10]
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2L)	OT3HG324	ASH2L_HUMAN	Increases Expression	[10]
Large neutral amino acids transporter small subunit 2 (SLC7A8)	OT8XXVO8	LAT2_HUMAN	Increases Expression	[10]
Bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)	OTB98CEY	BAZ2B_HUMAN	Decreases Expression	[10]
Frizzled-10 (FZD10)	OTSAENLT	FZD10_HUMAN	Increases Expression	[10]
Inhibitor of growth protein 4 (ING4)	OT0VVG4V	ING4_HUMAN	Decreases Expression	[10]
LIM and calponin homology domains-containing protein 1 (LIMCH1)	OTYPC4XA	LIMC1_HUMAN	Decreases Expression	[10]
Lysosome-associated membrane glycoprotein 3 (LAMP3)	OTN0XL3W	LAMP3_HUMAN	Increases Expression	[10]
Carbohydrate sulfotransferase 2 (CHST2)	OTV11IZF	CHST2_HUMAN	Increases Expression	[10]
Endothelial lipase (LIPG)	OTHEE942	LIPG_HUMAN	Increases Expression	[10]
Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1)	OT2NV3AN	CP11A_HUMAN	Decreases Expression	[42]
Insulin-like growth factor 1 receptor (IGF1R)	OTXJIF13	IGF1R_HUMAN	Decreases Expression	[42]
Cytochrome P450 11B1, mitochondrial (CYP11B1)	OTKKL894	C11B1_HUMAN	Decreases Expression	[42]
Serine/threonine-protein kinase mTOR (MTOR)	OTHH8KU7	MTOR_HUMAN	Decreases Expression	[42]
Steroidogenic factor 1 (NR5A1)	OTOULYR4	STF1_HUMAN	Decreases Expression	[42]
Sequestosome-1 (SQSTM1)	OTGY5D5J	SQSTM_HUMAN	Decreases Expression	[42]
Early growth response protein 1 (EGR1)	OTCP6XGZ	EGR1_HUMAN	Increases Expression	[43]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)	OTHF4H9U	DHI2_HUMAN	Decreases Expression	[43]
Cytochrome P450 2D6 (CYP2D6)	OTZJC802	CP2D6_HUMAN	Increases Expression	[44]
CCN family member 1 (CCN1)	OTKJBEMD	CCN1_HUMAN	Decreases Expression	[11]
Astrotactin-1 (ASTN1)	OT23FQIB	ASTN1_HUMAN	Increases Expression	[11]
Beta-1,4-glucuronyltransferase 1 (B4GAT1)	OT5NH9TD	B4GA1_HUMAN	Increases Expression	[11]
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G)	OT8V1J4M	GA45G_HUMAN	Decreases Expression	[11]
GTP-binding protein Di-Ras3 (DIRAS3)	OT3XHLQA	DIRA3_HUMAN	Increases Expression	[11]
Vitamin D-binding protein (GC)	OTWS63BY	VTDB_HUMAN	Decreases Expression	[11]
Coagulation factor XIII B chain (F13B)	OTIZXROK	F13B_HUMAN	Decreases Expression	[11]
Large ribosomal subunit protein P2 (RPLP2)	OT2YBK3W	RLA2_HUMAN	Increases Expression	[11]
Complement factor H (CFH)	OTAGKQTJ	CFAH_HUMAN	Decreases Expression	[11]
Osteopontin (SPP1)	OTJGC23Y	OSTP_HUMAN	Decreases Expression	[11]
Mast/stem cell growth factor receptor Kit (KIT)	OTHUY3VZ	KIT_HUMAN	Increases Expression	[11]
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MYL2)	OT78PC0C	MLRV_HUMAN	Decreases Expression	[11]
Cytochrome P450 2C9 (CYP2C9)	OTGLBN29	CP2C9_HUMAN	Decreases Expression	[11]
Sodium/glucose cotransporter 1 (SLC5A1)	OT0T78JI	SC5A1_HUMAN	Decreases Expression	[11]
Matrix metalloproteinase-9 (MMP9)	OTB2QDAV	MMP9_HUMAN	Increases Expression	[11]
Natriuretic peptides B (NPPB)	OTSN2IPY	ANFB_HUMAN	Decreases Expression	[11]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3)	OTC1UOHP	ATF3_HUMAN	Decreases Expression	[11]
Pro-thyrotropin-releasing hormone (TRH)	OT02UY2V	TRH_HUMAN	Increases Expression	[11]
Cytochrome P450 3A7 (CYP3A7)	OTTCDHHM	CP3A7_HUMAN	Decreases Expression	[11]
Endothelin receptor type B (EDNRB)	OTLLZV3P	EDNRB_HUMAN	Increases Expression	[11]
CCN family member 2 (CCN2)	OTC39NSU	CCN2_HUMAN	Decreases Expression	[11]
Radiation-inducible immediate-early gene IEX-1 (IER3)	OTZJI5FZ	IEX1_HUMAN	Decreases Expression	[11]
Retinoic acid receptor RXR-gamma (RXRG)	OT254B09	RXRG_HUMAN	Increases Expression	[11]
Sodium/myo-inositol cotransporter (SLC5A3)	OT6FY2KA	SC5A3_HUMAN	Increases Expression	[11]
10 kDa heat shock protein, mitochondrial (HSPE1)	OT7JSZLB	CH10_HUMAN	Increases Expression	[11]
Transgelin (TAGLN)	OTAEZ0KP	TAGL_HUMAN	Decreases Expression	[11]
Collagen alpha-1(XIV) chain (COL14A1)	OTLNJ13O	COEA1_HUMAN	Increases Expression	[11]
Ankyrin repeat domain-containing protein 1 (ANKRD1)	OTHJ7JV9	ANKR1_HUMAN	Decreases Expression	[11]
FRAS1-related extracellular matrix protein 2 (FREM2)	OTEK6BZR	FREM2_HUMAN	Increases Expression	[11]
OTU domain-containing protein 1 (OTUD1)	OTE6O5XB	OTUD1_HUMAN	Decreases Expression	[11]
Leiomodin-2 (LMOD2)	OTFXHQFL	LMOD2_HUMAN	Decreases Expression	[11]
Transmembrane protein 71 (TMEM71)	OTA7W26O	TMM71_HUMAN	Decreases Expression	[11]
Synaptotagmin-10 (SYT10)	OTVV19BW	SYT10_HUMAN	Increases Expression	[11]
Fc receptor-like A (FCRLA)	OT6MK4M1	FCRLA_HUMAN	Decreases Expression	[11]
Monocarboxylate transporter 14 (SLC16A14)	OTUGDEUV	MOT14_HUMAN	Increases Expression	[11]
Retrotransposon-derived protein PEG10 (PEG10)	OTWD2278	PEG10_HUMAN	Increases Expression	[11]
Dynein axonemal assembly factor 3 (DNAAF3)	OT3OHO0O	DAAF3_HUMAN	Decreases Expression	[11]
Arrestin domain-containing protein 4 (ARRDC4)	OTINJ0FX	ARRD4_HUMAN	Increases Expression	[11]
EMI domain-containing protein 1 (EMID1)	OTJ27FQ1	EMID1_HUMAN	Increases Expression	[11]
BTB/POZ domain-containing protein KCTD12 (KCTD12)	OTPYKT4Z	KCD12_HUMAN	Increases Expression	[11]
Chemokine-like protein TAFA-4 (TAFA4)	OT0RHMNG	TAFA4_HUMAN	Increases Expression	[11]
Hemicentin-1 (HMCN1)	OTLZAS0P	HMCN1_HUMAN	Increases Expression	[11]
SPARC-related modular calcium-binding protein 1 (SMOC1)	OTJG2JQY	SMOC1_HUMAN	Increases Expression	[11]
Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A)	OT5V52LN	TNR12_HUMAN	Decreases Expression	[11]
Inward rectifier potassium channel 16 (KCNJ16)	OT174UPV	KCJ16_HUMAN	Decreases Expression	[11]
Kv channel-interacting protein 2 (KCNIP2)	OTY4BLOJ	KCIP2_HUMAN	Increases Expression	[11]
Ras-like protein family member 12 (RASL12)	OTNAK9X4	RASLC_HUMAN	Increases Expression	[11]
Potassium voltage-gated channel subfamily G member 1 (KCNG1)	OTZ9ZRG8	KCNG1_HUMAN	Increases Expression	[11]
Probable small intestine urate exporter (SLC17A4)	OTFOOYB9	S17A4_HUMAN	Decreases Expression	[11]
Myosin-4 (MYH4)	OT4657W4	MYH4_HUMAN	Decreases Expression	[11]
Scinderin (SCIN)	OT6U09OL	SCIN_HUMAN	Increases Expression	[11]
Toll-like receptor 4 (TLR4)	OTP7ML3S	TLR4_HUMAN	Increases Expression	[45]
Dynamin-1-like protein (DNM1L)	OTXK1Q1G	DNM1L_HUMAN	Increases Expression	[46]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2)	OTKOZRZP	PLOD2_HUMAN	Increases Expression	[47]
Myc box-dependent-interacting protein 1 (BIN1)	OTK8O0X8	BIN1_HUMAN	Increases Expression	[13]
Stearoyl-CoA desaturase (SCD)	OTB1073G	SCD_HUMAN	Increases Expression	[48]
Telomerase reverse transcriptase (TERT)	OT085VVA	TERT_HUMAN	Decreases Expression	[49]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Increases Expression	[50]
Neuropilin-1 (NRP1)	OTCGULYV	NRP1_HUMAN	Decreases Expression	[13]
Histone-lysine N-methyltransferase SETD1A (SETD1A)	OTVVWRIC	SET1A_HUMAN	Decreases Expression	[50]
Phospholipid scramblase 1 (PLSCR1)	OTGY9B5T	PLS1_HUMAN	Affects Expression	[12]
Matrilin-3 (MATN3)	OTH9H74J	MATN3_HUMAN	Decreases Expression	[13]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Increases Expression	[51]
Toll-like receptor 3 (TLR3)	OT8QPYXZ	TLR3_HUMAN	Increases Expression	[45]
D-3-phosphoglycerate dehydrogenase (PHGDH)	OT1LMRTG	SERA_HUMAN	Increases Expression	[13]
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1)	OTDTF5BU	SUV91_HUMAN	Increases Expression	[50]
Forkhead box protein O3 (FOXO3)	OTHXQG4P	FOXO3_HUMAN	Increases Phosphorylation	[52]
5-hydroxymethyl-dUMP N-hydrolase (DNPH1)	OTEZVTI1	DNPH1_HUMAN	Decreases Expression	[53]
E3 ubiquitin-protein ligase parkin (PRKN)	OTJBN41W	PRKN_HUMAN	Decreases Expression	[54]
Dynamin-like 120 kDa protein, mitochondrial (OPA1)	OTJGNWPW	OPA1_HUMAN	Decreases Expression	[46]
Liprin-alpha-4 (PPFIA4)	OTWXG0DO	LIPA4_HUMAN	Decreases Expression	[13]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)	OTY9R6FZ	ERN1_HUMAN	Increases Expression	[55]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Increases Expression	[51]
Diacylglycerol O-acyltransferase 1 (DGAT1)	OTL104WL	DGAT1_HUMAN	Increases Expression	[56]
Cell cycle checkpoint protein RAD17 (RAD17)	OT1I93DT	RAD17_HUMAN	Decreases Expression	[13]
Solute carrier organic anion transporter family member 2B1 (SLCO2B1)	OTERJ4VQ	SO2B1_HUMAN	Increases Expression	[51]
Aflatoxin B1 aldehyde reductase member 3 (AKR7A3)	OTW3GO4Y	ARK73_HUMAN	Decreases Expression	[13]
6-phosphogluconolactonase (PGLS)	OTO6C0IQ	6PGL_HUMAN	Increases Expression	[13]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Decreases Expression	[50]
Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)	OTVT4YA1	ATG7_HUMAN	Increases Expression	[57]
Phospholipid-transporting ATPase ABCA1 (ABCA1)	OT94G6BQ	ABCA1_HUMAN	Decreases Expression	[58]
Claudin-14 (CLDN14)	OTS7GKOI	CLD14_HUMAN	Increases Expression	[59]
Complement factor D (CFD)	OTLNRXB6	CFAD_HUMAN	Increases Expression	[56]
Platelet-derived growth factor subunit B (PDGFB)	OTMFMFC3	PDGFB_HUMAN	Decreases Expression	[60]
Low-density lipoprotein receptor (LDLR)	OTH559LU	LDLR_HUMAN	Decreases Expression	[58]
Pro-opiomelanocortin (POMC)	OTV41F7T	COLI_HUMAN	Decreases Expression	[28]
Proenkephalin-B (PDYN)	OTEJ6430	PDYN_HUMAN	Decreases Expression	[28]
Somatotropin (GH1)	OT92RTRD	SOMA_HUMAN	Affects Folding	[61]
Interferon gamma (IFNG)	OTXG9JM7	IFNG_HUMAN	Increases Expression	[62]
Interleukin-1 alpha (IL1A)	OTPSGILV	IL1A_HUMAN	Decreases Expression	[63]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Increases Expression	[63]
C-reactive protein (CRP)	OT0RFT8F	CRP_HUMAN	Increases Expression	[64]
Fibronectin (FN1)	OTB5ZN4Q	FINC_HUMAN	Increases Expression	[65]
Transferrin receptor protein 1 (TFRC)	OT8ZPBDL	TFR1_HUMAN	Increases Expression	[65]
Ferritin light chain (FTL)	OTYQA8A6	FRIL_HUMAN	Increases Expression	[65]
Ferritin heavy chain (FTH1)	OT6IFS0O	FRIH_HUMAN	Decreases Expression	[54]
Estrogen receptor (ESR1)	OTKLU61J	ESR1_HUMAN	Increases Expression	[66]
Thymidine kinase, cytosolic (TK1)	OTY5JFM1	KITH_HUMAN	Decreases Activity	[67]
Insulin-like growth factor I (IGF1)	OTIIZR61	IGF1_HUMAN	Decreases Expression	[58]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)	OTM0GDTP	IF2A_HUMAN	Increases Expression	[55]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Decreases Expression	[63]
Keratin, type I cytoskeletal 18 (KRT18)	OTVLQFIP	K1C18_HUMAN	Increases Expression	[13]
Collagen alpha-2(V) chain (COL5A2)	OT5VOSQE	CO5A2_HUMAN	Increases Expression	[59]
Tyrosine-protein kinase Fyn (FYN)	OTLSLVZS	FYN_HUMAN	Increases Phosphorylation	[68]
ATP synthase subunit beta, mitochondrial (ATP5F1B)	OTLFZUQK	ATPB_HUMAN	Increases Expression	[13]
Alpha-enolase (ENO1)	OTB1KWJS	ENOA_HUMAN	Decreases Expression	[13]
Calpain-1 catalytic subunit (CAPN1)	OTK6OQZR	CAN1_HUMAN	Increases Expression	[69]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Increases Expression	[70]
Integrin alpha-5 (ITGA5)	OT3RCI67	ITA5_HUMAN	Increases Expression	[71]
Interleukin-3 (IL3)	OT0CQ35N	IL3_HUMAN	Increases Expression	[60]
High mobility group protein B1 (HMGB1)	OT4B7CPF	HMGB1_HUMAN	Increases Secretion	[72]
SPARC (SPARC)	OTPN90H0	SPRC_HUMAN	Increases Expression	[65]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Decreases Expression	[73]
Macrophage colony-stimulating factor 1 (CSF1)	OT68M7RD	CSF1_HUMAN	Increases Expression	[60]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[74]
Granulocyte colony-stimulating factor (CSF3)	OT9GC6TP	CSF3_HUMAN	Increases Expression	[60]
Chorionic somatomammotropin hormone 1 (CSH1)	OT33HTRR	CSH1_HUMAN	Decreases Expression	[13]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[75]
Clusterin (CLU)	OTQGG0JM	CLUS_HUMAN	Increases Expression	[65]
Endoplasmic reticulum chaperone BiP (HSPA5)	OTFUIRAO	BIP_HUMAN	Increases Expression	[55]
Heat shock cognate 71 kDa protein (HSPA8)	OTJI2RCI	HSP7C_HUMAN	Increases Expression	[76]
Acetylcholine receptor subunit beta (CHRNB1)	OTTJXD24	ACHB_HUMAN	Decreases Expression	[13]
Lysosome-associated membrane glycoprotein 1 (LAMP1)	OTYE92QY	LAMP1_HUMAN	Decreases Expression	[77]
Interleukin-7 (IL7)	OTT6YSKM	IL7_HUMAN	Increases Expression	[60]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Increases Expression	[78]
C-C motif chemokine 5 (CCL5)	OTSCA5CK	CCL5_HUMAN	Increases Secretion	[79]
Tissue factor (F3)	OT3MSU3B	TF_HUMAN	Increases Expression	[80]
Glial fibrillary acidic protein (GFAP)	OTQ01ZAS	GFAP_HUMAN	Increases Expression	[13]
Neutrophil cytosol factor 1 (NCF1)	OTMHT3G6	NCF1_HUMAN	Increases Expression	[81]
POU domain, class 2, transcription factor 1 (POU2F1)	OTK7ELJ0	PO2F1_HUMAN	Decreases Expression	[53]
Leukemia inhibitory factor (LIF)	OTO46S5S	LIF_HUMAN	Increases Expression	[59]
Ezrin (EZR)	OTHBPF1Z	EZRI_HUMAN	Increases Expression	[82]
Folate receptor alpha (FOLR1)	OT0QZ0H6	FOLR1_HUMAN	Decreases Expression	[83]
Nucleoside diphosphate kinase A (NME1)	OT0NELQ1	NDKA_HUMAN	Increases Expression	[13]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Expression	[49]
Cyclic AMP-responsive element-binding protein 1 (CREB1)	OT1MDLA1	CREB1_HUMAN	Increases Phosphorylation	[69]
High mobility group protein HMG-I/HMG-Y (HMGA1)	OTQUSHPX	HMGA1_HUMAN	Increases Expression	[49]
Insulin-like growth factor-binding protein 3 (IGFBP3)	OTIX63TX	IBP3_HUMAN	Increases Expression	[65]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Increases Expression	[55]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)	OT2D9DOV	TNR1A_HUMAN	Increases Expression	[60]
Spermidine synthase (SRM)	OT4N5MDP	SPEE_HUMAN	Decreases Expression	[13]
Retinoic acid receptor RXR-alpha (RXRA)	OTP1TBDM	RXRA_HUMAN	Decreases Expression	[50]
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)	OTDS2EAR	TNR1B_HUMAN	Increases Expression	[60]
Interleukin-11 (IL11)	OTXHN86R	IL11_HUMAN	Increases Expression	[84]
Cytochrome P450 2B6 (CYP2B6)	OTOYO4S7	CP2B6_HUMAN	Increases Expression	[25]
Hepatocyte nuclear factor 1-alpha (HNF1A)	OT9DOUKL	HNF1A_HUMAN	Decreases Expression	[64]
Fibroblast growth factor receptor 2 (FGFR2)	OTLOPACK	FGFR2_HUMAN	Increases Expression	[71]
Alpha-(1,3)-fucosyltransferase 4 (FUT4)	OTIBXRTL	FUT4_HUMAN	Increases Expression	[85]
Sterol carrier protein 2 (SCP2)	OTPAFCPQ	SCP2_HUMAN	Decreases Expression	[13]
Galanin peptides (GAL)	OTB3VPTO	GALA_HUMAN	Increases Expression	[49]
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)	OTBZKX4P	ROA2_HUMAN	Increases Expression	[13]
Alanine aminotransferase 1 (GPT)	OTOXOA0Q	ALAT1_HUMAN	Increases Activity	[86]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Increases Expression	[71]
Protein S100-A4 (S100A4)	OTLRGFSQ	S10A4_HUMAN	Increases Expression	[65]
Beta-crystallin B3 (CRYBB3)	OTTGTQIQ	CRBB3_HUMAN	Decreases Expression	[53]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Decreases Expression	[53]
Lysine-specific demethylase 5A (KDM5A)	OTLYFX8A	KDM5A_HUMAN	Decreases Expression	[50]
Caspase-1 (CASP1)	OTZ3YQFU	CASP1_HUMAN	Increases Expression	[63]
Endoplasmic reticulum resident protein 29 (ERP29)	OTNKANMH	ERP29_HUMAN	Increases Expression	[13]
Peroxiredoxin-6 (PRDX6)	OTS8KC8A	PRDX6_HUMAN	Decreases Expression	[13]
G1/S-specific cyclin-D2 (CCND2)	OTDULQF9	CCND2_HUMAN	Decreases Expression	[75]
M-phase inducer phosphatase 2 (CDC25B)	OT12MSRY	MPIP2_HUMAN	Increases Expression	[13]
Neuronal acetylcholine receptor subunit alpha-5 (CHRNA5)	OTGIL2YD	ACHA5_HUMAN	Affects Expression	[87]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Decreases Expression	[58]
Neural cell adhesion molecule L1 (L1CAM)	OTNWAQ4Y	L1CAM_HUMAN	Decreases Activity	[88]
Cadherin-5 (CDH5)	OTVX0E1Q	CADH5_HUMAN	Increases Uptake	[89]
Prohibitin 1 (PHB1)	OTZNXYS2	PHB1_HUMAN	Increases Expression	[13]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Increases Expression	[55]
Sterol regulatory element-binding protein 1 (SREBF1)	OTWBRPAI	SRBP1_HUMAN	Increases Expression	[86]
Peroxisome proliferator-activated receptor gamma (PPARG)	OTHMARHO	PPARG_HUMAN	Decreases Expression	[49]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[49]
Kappa-type opioid receptor (OPRK1)	OTXCZF4L	OPRK_HUMAN	Decreases Expression	[28]
Lysine-specific demethylase 5C (KDM5C)	OTZ6E0HY	KDM5C_HUMAN	Decreases Expression	[50]
Reduced folate transporter (SLC19A1)	OTWB0BTO	S19A1_HUMAN	Decreases Expression	[90]
C-C chemokine receptor type 2 (CCR2)	OTQ7T10J	CCR2_HUMAN	Increases Expression	[78]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Expression	[58]
Cyclin-dependent kinase inhibitor 2A (CDKN2A)	OTN0ZWAE	CDN2A_HUMAN	Increases Expression	[49]
ATP-binding cassette sub-family G member 1 (ABCG1)	OT5BG6MK	ABCG1_HUMAN	Decreases Expression	[58]
Proliferation marker protein Ki-67 (MKI67)	OTA8N1QI	KI67_HUMAN	Decreases Expression	[58]
F-actin-capping protein subunit beta (CAPZB)	OTF1A4N0	CAPZB_HUMAN	Increases Expression	[13]
Glutamate--cysteine ligase catalytic subunit (GCLC)	OTESDI4D	GSH1_HUMAN	Increases Expression	[91]
Fatty acid synthase (FASN)	OTFII9KG	FAS_HUMAN	Increases Expression	[56]
Amphiphysin (AMPH)	OTWPGWZX	AMPH_HUMAN	Decreases Expression	[13]
CCAAT/enhancer-binding protein alpha (CEBPA)	OTOM9OE4	CEBPA_HUMAN	Increases Expression	[92]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)	OTI862QH	CPT1A_HUMAN	Decreases Expression	[86]
Eotaxin (CCL11)	OT3BIFPK	CCL11_HUMAN	Decreases Expression	[60]
Telomeric repeat-binding factor 1 (TERF1)	OTIJCMGB	TERF1_HUMAN	Increases Expression	[49]
Mismatch repair endonuclease PMS2 (PMS2)	OTNLWTMI	PMS2_HUMAN	Decreases Expression	[53]
GTP-binding protein RAD (RRAD)	OTW2O4GD	RAD_HUMAN	Decreases Expression	[53]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Cleavage	[50]
Sodium/calcium exchanger 3 (SLC8A3)	OTIVTE0G	NAC3_HUMAN	Increases Expression	[69]
Sestrin-2 (SESN2)	OT889IXY	SESN2_HUMAN	Decreases Expression	[77]
Heterogeneous nuclear ribonucleoprotein K (HNRNPK)	OTNPRM8U	HNRPK_HUMAN	Increases Expression	[13]
Ras-related C3 botulinum toxin substrate 1 (RAC1)	OTKRO61U	RAC1_HUMAN	Increases Localization	[68]
Hepcidin (HAMP)	OT607RBL	HEPC_HUMAN	Decreases Expression	[93]
Caveolin-1 (CAV1)	OTEZUR1L	CAV1_HUMAN	Increases Expression	[65]
Histone-lysine N-methyltransferase 2A (KMT2A)	OT9GLJI6	KMT2A_HUMAN	Decreases Expression	[50]
Protein kinase C delta type (PRKCD)	OTSEH90E	KPCD_HUMAN	Increases Phosphorylation	[68]
Peroxiredoxin-1 (PRDX1)	OTZ3BEC4	PRDX1_HUMAN	Increases Expression	[13]
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP)	OTPYQX3K	C1QBP_HUMAN	Decreases Expression	[13]
Tight junction protein ZO-1 (TJP1)	OTBDCUPK	ZO1_HUMAN	Decreases Expression	[94]
C-X-C motif chemokine 9 (CXCL9)	OTMFVZKZ	CXCL9_HUMAN	Decreases Expression	[60]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Increases Expression	[58]
DNA polymerase epsilon catalytic subunit A (POLE)	OTFM3MMU	DPOE1_HUMAN	Decreases Expression	[13]
Peroxisome proliferator-activated receptor alpha (PPARA)	OTK095PP	PPARA_HUMAN	Decreases Expression	[86]
AP-1 complex subunit beta-1 (AP1B1)	OTY0K84R	AP1B1_HUMAN	Increases Expression	[13]
Forkhead box protein O1 (FOXO1)	OTPJRB6D	FOXO1_HUMAN	Decreases Phosphorylation	[95]
Acetyl-CoA carboxylase 1 (ACACA)	OT5CQPZY	ACACA_HUMAN	Decreases Phosphorylation	[95]
Oxysterols receptor LXR-alpha (NR1H3)	OT54YZ9I	NR1H3_HUMAN	Increases Expression	[92]
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)	OTC41R1E	RIPK1_HUMAN	Increases Expression	[72]
Stromal interaction molecule 1 (STIM1)	OT8CLQ1W	STIM1_HUMAN	Increases Expression	[96]
Nuclear receptor coactivator 4 (NCOA4)	OTRVU0UA	NCOA4_HUMAN	Increases Expression	[54]
Runt-related transcription factor 2 (RUNX2)	OT97RQQM	RUNX2_HUMAN	Increases Expression	[97]
Pro-interleukin-16 (IL16)	OTZ2MO6B	IL16_HUMAN	Decreases Expression	[60]
Interleukin-18 (IL18)	OTBB2A8O	IL18_HUMAN	Increases Expression	[63]
Protein scribble homolog (SCRIB)	OTW4N3FV	SCRIB_HUMAN	Decreases Expression	[13]
Protein-tyrosine kinase 2-beta (PTK2B)	OTGAS0I8	FAK2_HUMAN	Increases Phosphorylation	[68]
Caprin-1 (CAPRIN1)	OTEJAMS3	CAPR1_HUMAN	Increases Expression	[12]
Beclin-1 (BECN1)	OT4X293M	BECN1_HUMAN	Increases Expression	[57]
Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1)	OTX7MWW1	ITPR1_HUMAN	Increases Expression	[98]
Phosphatidate phosphatase LPIN1 (LPIN1)	OTQ75KF2	LPIN1_HUMAN	Increases Expression	[92]
Glycine N-methyltransferase (GNMT)	OT0O2OQO	GNMT_HUMAN	Increases Expression	[59]
Nuclear factor of activated T-cells, cytoplasmic 4 (NFATC4)	OTTDCUAO	NFAC4_HUMAN	Increases Expression	[49]
Retinoblastoma-binding protein 5 (RBBP5)	OT12W2MK	RBBP5_HUMAN	Increases Expression	[50]
Calponin-3 (CNN3)	OTJTAXAP	CNN3_HUMAN	Decreases Expression	[13]
Myosin light chain kinase, smooth muscle (MYLK)	OT78QB4A	MYLK_HUMAN	Increases Expression	[94]
Histone-lysine N-methyltransferase EZH2 (EZH2)	OTIEHTKW	EZH2_HUMAN	Decreases Expression	[50]
Nuclear factor erythroid 2-related factor 2 (NFE2L2)	OT0HENJ5	NF2L2_HUMAN	Decreases Expression	[72]
Interleukin-17A (IL17A)	OTY72FT2	IL17_HUMAN	Decreases Expression	[60]
Frataxin, mitochondrial (FXN)	OTE9U09A	FRDA_HUMAN	Affects Expression	[99]
Occludin (OCLN)	OTSUTVWL	OCLN_HUMAN	Decreases Expression	[94]
Histone-lysine N-methyltransferase KMT5B (KMT5B)	OTOH7G8Q	KMT5B_HUMAN	Affects Expression	[50]
Centrosomal protein of 55 kDa (CEP55)	OTGSG2PA	CEP55_HUMAN	Decreases Expression	[13]
F-box/WD repeat-containing protein 9 (FBXW9)	OTM2MFOF	FBXW9_HUMAN	Decreases Expression	[13]
Dual specificity phosphatase 29 (DUSP29)	OTJOJZHG	DUS29_HUMAN	Increases Expression	[13]
Coiled-coil domain-containing protein 70 (CCDC70)	OTQMZUYJ	CCD70_HUMAN	Decreases Expression	[13]
Inactive caspase-12 (CASP12)	OTY2W6FG	CASPC_HUMAN	Increases Activity	[55]
Hsp90 co-chaperone Cdc37-like 1 (CDC37L1)	OTGKTFAC	CD37L_HUMAN	Decreases Expression	[65]
Autophagy-related protein 9A (ATG9A)	OTAZWZH7	ATG9A_HUMAN	Decreases Expression	[13]
Mitofusin-1 (MFN1)	OTCBXQZF	MFN1_HUMAN	Decreases Expression	[46]
NAD-dependent protein deacetylase sirtuin-2 (SIRT2)	OT5Q6SVK	SIR2_HUMAN	Decreases Expression	[62]
Stromal membrane-associated protein 1 (SMAP1)	OTQN3BVL	SMAP1_HUMAN	Increases Expression	[13]
Inactive histone-lysine N-methyltransferase 2E (KMT2E)	OTYOLNOG	KMT2E_HUMAN	Decreases Expression	[50]
Mixed lineage kinase domain-like protein (MLKL)	OTDSLC81	MLKL_HUMAN	Increases Phosphorylation	[62]
Histone-lysine N-methyltransferase 2C (KMT2C)	OTC59BCO	KMT2C_HUMAN	Decreases Expression	[50]
Coiled-coil alpha-helical rod protein 1 (CCHCR1)	OT22C116	CCHCR_HUMAN	Decreases Expression	[13]
Histone-lysine N-methyltransferase SETD7 (SETD7)	OTT49OXF	SETD7_HUMAN	Increases Expression	[50]
Scavenger receptor class B member 1 (SCARB1)	OTAE1UA1	SCRB1_HUMAN	Decreases Expression	[58]
Transcription factor IIIB 90 kDa subunit (BRF1)	OTQC6DMG	TF3B_HUMAN	Increases Expression	[97]
Calcium release-activated calcium channel protein 1 (ORAI1)	OT2VE9UU	CRCM1_HUMAN	Increases Expression	[96]
NAD-dependent protein deacetylase sirtuin-1 (SIRT1)	OTAYZMOY	SIR1_HUMAN	Decreases Expression	[95]
Kremen protein 1 (KREMEN1)	OTGJFSAC	KREM1_HUMAN	Decreases Expression	[13]
Nectin-4 (NECTIN4)	OTJSFW1L	NECT4_HUMAN	Decreases Expression	[59]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3)	OTZM6MHU	NLRP3_HUMAN	Increases Expression	[62]
Diacylglycerol O-acyltransferase 2 (DGAT2)	OTE5PDD0	DGAT2_HUMAN	Increases Expression	[56]
Bile acid receptor (NR1H4)	OTWZLPTB	NR1H4_HUMAN	Decreases Expression	[86]
Histone-lysine N-methyltransferase SETDB2 (SETDB2)	OTBVVP9Q	SETB2_HUMAN	Decreases Expression	[50]
Prefoldin subunit 5 (PFDN5)	OTTKPTUP	PFD5_HUMAN	Decreases Expression	[53]
tRNA-specific adenosine deaminase 1 (ADAT1)	OTCDIRF4	ADAT1_HUMAN	Decreases Expression	[65]
Serine/threonine-protein kinase PINK1, mitochondrial (PINK1)	OT50NR57	PINK1_HUMAN	Decreases Expression	[54]
Fanconi anemia group D2 protein (FANCD2)	OTVEB5LF	FACD2_HUMAN	Increases Expression	[100]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)	OTUYHB84	MLP3B_HUMAN	Increases Expression	[57]
Autophagy protein 5 (ATG5)	OT4T5SMS	ATG5_HUMAN	Decreases Expression	[101]
Leucine-rich melanocyte differentiation-associated protein (LRMDA)	OTIPNKTU	LRMDA_HUMAN	Increases Expression	[59]
Histone-lysine N-methyltransferase SUV39H2 (SUV39H2)	OTU0F4LL	SUV92_HUMAN	Decreases Expression	[50]
Prokineticin-2 (PROK2)	OT70IFEZ	PROK2_HUMAN	Increases Expression	[12]
Glyoxalase domain-containing protein 4 (GLOD4)	OTBJKFXA	GLOD4_HUMAN	Decreases Expression	[13]
N-lysine methyltransferase KMT5A (KMT5A)	OTW2A5YY	KMT5A_HUMAN	Decreases Expression	[50]
StAR-related lipid transfer protein 7, mitochondrial (STARD7)	OTDUZ296	STAR7_HUMAN	Decreases Expression	[13]
Histone-lysine N-methyltransferase ASH1L (ASH1L)	OTUT5NLJ	ASH1L_HUMAN	Decreases Expression	[50]
N-lysine methyltransferase SMYD2 (SMYD2)	OTN8035R	SMYD2_HUMAN	Decreases Expression	[50]
Phospholipid scramblase 3 (PLSCR3)	OTJ6K2XJ	PLS3_HUMAN	Increases Expression	[13]
Interleukin-1 receptor-associated kinase 4 (IRAK4)	OT9JTJWC	IRAK4_HUMAN	Increases Expression	[63]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)	OT0DZGY4	E2AK3_HUMAN	Increases Expression	[55]
DNA (DNMT3B)	OTZ0JCNP	DNM3B_HUMAN	Affects Expression	[50]
Tripartite motif-containing protein 10 (TRIM10)	OTEO4UCZ	TRI10_HUMAN	Increases Expression	[13]
Lysine-specific demethylase 5B (KDM5B)	OT5DL94T	KDM5B_HUMAN	Decreases Expression	[50]
Adenine DNA glycosylase (MUTYH)	OTXTKI7Q	MUTYH_HUMAN	Decreases Expression	[53]
Apoptosis-associated speck-like protein containing a CARD (PYCARD)	OT67RON3	ASC_HUMAN	Increases Expression	[81]
Histone-lysine N-methyltransferase 2B (KMT2B)	OTMMAZQX	KMT2B_HUMAN	Decreases Expression	[50]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Increases Expression	[51]
Dystrobrevin alpha (DTNA)	OTVBIRH2	DTNA_HUMAN	Increases Expression	[13]
Lysyl oxidase homolog 2 (LOXL2)	OTRT46B5	LOXL2_HUMAN	Increases Expression	[65]
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)	OTL1D484	RIPK3_HUMAN	Increases Expression	[72]
DNA (DNMT3A)	OTEJP0GH	DNM3A_HUMAN	Affects Expression	[50]
Regenerating islet-derived protein 3-alpha (REG3A)	OT0BVQRB	REG3A_HUMAN	Increases ADR	[102]
Mu-type opioid receptor (OPRM1)	OT16AAT8	OPRM_HUMAN	Increases Response To Substance	[103]
Insulin receptor substrate 2 (IRS2)	OT46MJBE	IRS2_HUMAN	Increases ADR	[102]
Rabphilin-3A (RPH3A)	OT5VS65E	RP3A_HUMAN	Affects Response To Substance	[92]
2'-5'-oligoadenylate synthase 3 (OAS3)	OT6E5FYS	OAS3_HUMAN	Affects Response To Substance	[92]
Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11)	OT7EVFBK	M2OM_HUMAN	Increases ADR	[102]
Neuronal cell adhesion molecule (NRCAM)	OT80HHQ2	NRCAM_HUMAN	Increases Response To Substance	[104]
GABA receptor subunit B1 (GABAB1)	OT8KS945	M9TEZ7_TETCI	Increases ADR	[102]
Serine protease 1 (PRSS1)	OTA425AX	TRY1_HUMAN	Increases ADR	[105]
Signal transducer and activator of transcription 3 (STAT3)	OTAAGKYZ	STAT3_HUMAN	Increases ADR	[102]
D(2) dopamine receptor (DRD2)	OTBLXKEG	DRD2_HUMAN	Increases ADR	[102]
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)	OTBPMIMW	G3P_HUMAN	Increases ADR	[102]
Eukaryotic translation initiation factor 4E (EIF4E)	OTDAWNLA	IF4E_HUMAN	Increases ADR	[102]
Ribosomal protein S6 kinase alpha-1 (RPS6KA1)	OTDOTWU4	KS6A1_HUMAN	Affects Response To Substance	[106]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A)	OTFBU4GD	P3C2A_HUMAN	Increases ADR	[102]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)	OTHBQVD5	4EBP1_HUMAN	Increases ADR	[102]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Decreases Response To Substance	[107]
Small ribosomal subunit protein eS6z (RPS6A)	OTIG8G1R	RS61_ARATH	Increases ADR	[102]
Ankyrin-3 (ANK3)	OTJ3IRBP	ANK3_HUMAN	Affects Response To Substance	[106]
MORC family CW-type zinc finger protein 4 (MORC4)	OTJBEHNE	MORC4_HUMAN	Increases ADR	[105]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Increases ADR	[102]
Coiled-coil domain-containing protein 63 (CCDC63)	OTKDRXAE	CCD63_HUMAN	Affects Response To Substance	[92]
Low-density lipoprotein receptor-related protein 6 (LRP6)	OTM7PSUR	LRP6_HUMAN	Decreases Response To Substance	[108]
Insulin receptor substrate 1 (IRS1)	OTNO82CU	IRS1_HUMAN	Increases ADR	[102]
Adiponectin (ADIPOQ)	OTNX23LE	ADIPO_HUMAN	Decreases Response To Substance	[101]
HLA class I histocompatibility antigen, B alpha chain (HLA-B)	OTNXFWY2	HLAB_HUMAN	Increases ADR	[109]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)	OTOA8WU2	PDE4B_HUMAN	Affects Response To Substance	[110]
Cyclin-dependent kinase 20 (CDK20)	OTOLNN68	CDK20_HUMAN	Affects Response To Substance	[110]
Myeloperoxidase (MPO)	OTOOXLIN	PERM_HUMAN	Increases ADR	[102]
Sex hormone-binding globulin (SHBG)	OTPWU5IW	SHBG_HUMAN	Increases ADR	[102]
Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R)	OTQF5ZAK	PTH1R_HUMAN	Increases ADR	[102]
Glutathione S-transferase theta-1 (GSTT1)	OTRFMWBK	GSTT1_HUMAN	Affects Response To Substance	[111]
Opioid growth factor receptor (OGFR)	OTROS6RJ	OGFR_HUMAN	Increases ADR	[102]
Period circadian protein homolog 2 (PER2)	OTU2B1DJ	PER2_HUMAN	Affects Response To Substance	[112]
T-box transcription factor TBX19 (TBX19)	OTXEMR2U	TBX19_HUMAN	Affects Response To Substance	[110]
Protein DEK (DEK)	OTYCJ5H6	DEK_HUMAN	Increases Secretion	[113]
Insulin (INS)	OTZ85PDU	INS_HUMAN	Increases ADR	[102]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Affects Response To Substance	[114]

Indication(s) of Lidocaine

Disease Entry	ICD 11	Status	REF
Anaesthesia	9A78.6	Approved	[4]
Carpal tunnel syndrome	N.A.	Approved	[5]
Interstitial cystitis	GC00.3	Approved	[5]
Long QT syndrome	BC65.0	Approved	[5]
Pain	MG30-MG3Z	Approved	[5]
Pediculus capitis infestation	1G00.0	Approved	[5]
Periodontitis	DA0C	Approved	[5]
Postherpetic neuralgia	1E91.5	Approved	[5]
Pthirus pubis infestation	N.A.	Approved	[5]
Dysmenorrhea	GA34.3	Phase 2	[6]
Chronic pain	MG30	Investigative	[5]
Neuralgia	N.A.	Investigative	[5]
Premature ejaculation	HA03.0Z	Investigative	[5]
Pruritus	EC90	Investigative	[5]

Lidocaine Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Voltage-gated sodium channel alpha Nav1.9 (SCN11A)	TTN9VTF	SCNBA_HUMAN	Blocker	[116]

Lidocaine Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[117]

Lidocaine Interacts with 10 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[118]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[119]
Cytochrome P450 2A6 (CYP2A6)	DEJVYAZ	CP2A6_HUMAN	Metabolism	[16]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Metabolism	[120]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[121]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Metabolism	[121]
Cytochrome P450 2C18 (CYP2C18)	DEZMWRE	CP2CI_HUMAN	Metabolism	[16]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Metabolism	[16]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Metabolism	[16]
Cytochrome P450 2B6 (CYP2B6)	DEPKLMQ	CP2B6_HUMAN	Metabolism	[122]

Lidocaine Interacts with 23 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Decreases Ethylation	[123]
Cytochrome P450 3A5 (CYP3A5)	OTSXFBXB	CP3A5_HUMAN	Decreases Methylation	[124]
Alpha-1-acid glycoprotein 1 (ORM1)	OTZKSBRE	A1AG1_HUMAN	Affects Binding	[125]
C-reactive protein (CRP)	OT0RFT8F	CRP_HUMAN	Increases ADR	[102]
Glutathione hydrolase 1 proenzyme (GGT1)	OTYDA1Z7	GGT1_HUMAN	Increases ADR	[102]
Alkaline phosphatase, placental type (ALPP)	OTZU4G9W	PPB1_HUMAN	Increases ADR	[102]
Estrogen receptor (ESR1)	OTKLU61J	ESR1_HUMAN	Increases Expression	[126]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Increases Activity	[127]
Kininogen-1 (KNG1)	OT4X9LDE	KNG1_HUMAN	Decreases Activity	[128]
Beta-nerve growth factor (NGF)	OTOLABJT	NGF_HUMAN	Decreases Expression	[115]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Decreases Expression	[129]
Neurofilament medium polypeptide (NEFM)	OT8VCBNF	NFM_HUMAN	Decreases Expression	[115]
Alpha-1-acid glycoprotein 2 (ORM2)	OTRJGZP8	A1AG2_HUMAN	Affects Binding	[125]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Decreases Expression	[130]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Decreases Expression	[130]
Potassium voltage-gated channel subfamily H member 2 (KCNH2)	OTZX881H	KCNH2_HUMAN	Decreases Activity	[131]
Neuronatin (NNAT)	OTNRLO7G	NNAT_HUMAN	Decreases Expression	[115]
Transient receptor potential cation channel subfamily V member 1 (TRPV1)	OTHHDR03	TRPV1_HUMAN	Increases Activity	[132]
Sulfotransferase 1A1 (SULT1A1)	OT0K7JIE	ST1A1_HUMAN	Increases Sulfation	[133]
Histamine H1 receptor (HRH1)	OT8F9FV6	HRH1_HUMAN	Affects Binding	[134]
Endoplasmic reticulum chaperone BiP (HSPA5)	OTFUIRAO	BIP_HUMAN	Increases ADR	[102]
Sodium channel protein type 5 subunit alpha (SCN5A)	OTGYZWR6	SCN5A_HUMAN	Affects Response To Substance	[135]
Sulfotransferase 1B1 (SULT1B1)	OTH0RQYA	ST1B1_HUMAN	Increases Sulfation	[133]

References

• [1] ClinicalTrials.gov (NCT02158039) Endoscopic Ultrasound-guided Ethanol Injection of Pancreatic Cystic Neoplasms
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2299).
• [3] Ethanol FDA Label
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2623).
• [5] Lidocaine FDA Label
• [6] ClinicalTrials.gov (NCT00651313) Efficacy and Safety Study of Lidocaine Vaginal Gel for Recurrent Dysmenorrhea (Painful Periods). U.S. National Institutes of Health.
• [7] Mechanism of alcohol-induced oxidative stress and neuronal injury. Free Radic Biol Med. 2008 Dec 1;45(11):1542-50.
• [8] Differences in the activities of resveratrol and ascorbic acid in protection of ethanol-induced oxidative DNA damage in human peripheral lymphocytes. Food Chem Toxicol. 2012 Feb;50(2):168-74.
• [9] Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
• [10] Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
• [11] Cardiac toxicity from ethanol exposure in human-induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci. 2019 May 1;169(1):280-292.
• [12] Bisphenol A alters transcript levels of biomarker genes for Major Depressive Disorder in vascular endothelial cells and colon cancer cells. Chemosphere. 2016 Jun;153:75-7. doi: 10.1016/j.chemosphere.2015.12.085. Epub 2016 Mar 21.
• [13] Effects of acute ethanol treatment on NCCIT cells and NCCIT cell-derived embryoid bodies (EBs). Toxicol In Vitro. 2010 Sep;24(6):1696-704. doi: 10.1016/j.tiv.2010.05.017. Epub 2010 May 26.
• [14] Non-oxidative ethanol metabolism in human hepatic cells in vitro: Involvement of uridine diphospho-glucuronosyltransferase 1A9 in ethylglucuronide production. Toxicol In Vitro. 2020 Aug;66:104842. doi: 10.1016/j.tiv.2020.104842. Epub 2020 Apr 10.
• [15] DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6.
• [16] Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
• [17] Identification and preliminary characterization of UDP-glucuronosyltransferases catalyzing formation of ethyl glucuronide. Anal Bioanal Chem. 2014 Apr;406(9-10):2325-32.
• [18] CYP2E1 and clinical features in alcoholics. Neuropsychobiology. 2003;47(2):86-9.
• [19] Functional assessment of human alcohol dehydrogenase family in ethanol metabolism: significance of first-pass metabolism. Alcohol Clin Exp Res. 2006 Jul;30(7):1132-42.
• [20] Natural alcohol exposure: is ethanol the main substrate for alcohol dehydrogenases in animals? Chem Biol Interact. 2011 May 30;191(1-3):14-25.
• [21] Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology. 2008 Mar 12;245(1-2):65-75.
• [22] Functional profiles of coronal and dentin caries in children. J Oral Microbiol. 2018 Jul 16;10(1):1495976.
• [23] CYP4F2 repression and a modified alpha-tocopherol (vitamin E) metabolism are two independent consequences of ethanol toxicity in human hepatocytes. Toxicol In Vitro. 2017 Apr;40:124-133.
• [24] An in vitro model of human acute ethanol exposure that incorporates CXCR3- and CXCR4-dependent recruitment of immune cells. Toxicol Sci. 2013 Mar;132(1):131-41.
• [25] Prenatal ethanol exposure induces dynamic changes of expression and activity of hepatic cytochrome P450 isoforms in male rat offspring. Reprod Toxicol. 2022 Apr;109:101-108. doi: 10.1016/j.reprotox.2022.03.002. Epub 2022 Mar 14.
• [26] The Janus face of alcohol dehydrogenase 3. Chem Biol Interact. 2009 Mar 16;178(1-3):29-35. doi: 10.1016/j.cbi.2008.10.050. Epub 2008 Nov 6.
• [27] Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
• [28] The role of acetaldehyde in mediating effects of alcohol on expression of endogenous opioid system genes in a neuroblastoma cell line. FASEB J. 2008 Mar;22(3):662-70. doi: 10.1096/fj.07-8346com. Epub 2007 Oct 12.
• [29] Association of polymorphism in alcohol dehydrogenase and interaction with other genetic risk factors with alcoholic liver cirrhosis. Drug Alcohol Depend. 2010 Jun 1;109(1-3):190-7. doi: 10.1016/j.drugalcdep.2010.01.010. Epub 2010 Feb 18.
• [30] Cytokine response and oxidative stress produced by ethanol, acetaldehyde and endotoxin treatment in HepG2 cells. Isr Med Assoc J. 2001 Feb;3(2):131-6.
• [31] Solvent effect on cDNA-expressed human sulfotransferase (SULT) activities in vitro. Drug Metab Dispos. 2003 Nov;31(11):1300-5.
• [32] Ethanol inhibits methionine adenosyltransferase II activity and S-adenosylmethionine biosynthesis and enhances caspase-3-dependent cell death in T lymphocytes: relevance to alcohol-induced immunosuppression. J Nutr Biochem. 2008 Jun;19(6):384-91.
• [33] NF-kappaB-activated tissue transglutaminase is involved in ethanol-induced hepatic injury and the possible role of propolis in preventing fibrogenesis. Toxicology. 2008 Apr 18;246(2-3):148-57.
• [34] Prediction of the contact sensitizing potential of chemicals using analysis of gene expression changes in human THP-1 monocytes. Toxicol Lett. 2010 Nov 10;199(1):51-9.
• [35] Ethanol-mediated regulation of cytochrome P450 2A6 expression in monocytes: role of oxidative stress-mediated PKC/MEK/Nrf2 pathway. PLoS One. 2012;7(4):e35505.
• [36] Alcohol depletes coenzyme-Q(10) associated with increased TNF-alpha secretion to induce cytotoxicity in HepG2 cells. Toxicology. 2012 Dec 8;302(1):34-9.
• [37] Ethanol enhances arsenic-induced cyclooxygenase-2 expression via both NFAT and NF-B signalings in colorectal cancer cells. Toxicol Appl Pharmacol. 2015 Oct 15;288(2):232-9.
• [38] Monoamine oxidase inhibitory activity in tobacco particulate matter: Are harman and norharman the only physiologically relevant inhibitors? Neurotoxicology. 2017 Mar;59:22-26.
• [39] The induction of cytochrome P450 2E1 by ethanol leads to the loss of synaptic proteins via PPARalpha down-regulation. Toxicology. 2017 Jun 15;385:18-27.
• [40] Flavonoid composition of orange peel extract ameliorates alcohol-induced tight junction dysfunction in Caco-2 monolayer. Food Chem Toxicol. 2017 Jul;105:398-406.
• [41] Study of acetylcholinesterase activity and apoptosis in SH-SY5Y cells and mice exposed to ethanol. Toxicology. 2017 Jun 1;384:33-39.
• [42] Autophagy as a compensation mechanism participates in ethanol-induced fetal adrenal dysfunction in female rats. Toxicol Appl Pharmacol. 2018 Apr 15;345:36-47.
• [43] cAMP/PKA/EGR1 signaling mediates the molecular mechanism of ethanol-induced inhibition of placental 11beta-HSD2 expression. Toxicol Appl Pharmacol. 2018 Aug 1;352:77-86.
• [44] beta-Naphtoflavone and ethanol induce cytochrome P450 and protect towards MPP+ toxicity in human neuroblastoma SH-SY5Y cells. Int J Mol Sci. 2018 Oct 28;19(11).
• [45] Chronic ethanol exposure induces neuroinflammation in H4 cells through TLR3 / NF-B pathway and anxiety-like behavior in male C57BL/6 mice. Toxicology. 2020 Dec 15;446:152625. doi: 10.1016/j.tox.2020.152625. Epub 2020 Nov 5.
• [46] Protective effects of silibinin against ethanol- or acetaldehyde-caused damage in liver cell lines involve the repression of mitochondrial fission. Toxicol In Vitro. 2022 Apr;80:105330. doi: 10.1016/j.tiv.2022.105330. Epub 2022 Feb 11.
• [47] Identification of differentially expressed genes in hepatic HepG2 cells treated with acetaminophen using suppression subtractive hybridization. Biol Pharm Bull. 2005 Jul;28(7):1148-53. doi: 10.1248/bpb.28.1148.
• [48] Oroxylin A prevents alcohol-induced hepatic steatosis through inhibition of hypoxia inducible factor 1alpha. Chem Biol Interact. 2018 Apr 1;285:14-20. doi: 10.1016/j.cbi.2018.02.025. Epub 2018 Feb 21.
• [49] NFATc4 mediates ethanol-triggered hepatocyte senescence. Toxicol Lett. 2021 Oct 10;350:10-21. doi: 10.1016/j.toxlet.2021.06.018. Epub 2021 Jun 27.
• [50] Alcohol triggered bile acid disequilibrium by suppressing BSEP to sustain hepatocellular carcinoma progression. Chem Biol Interact. 2022 Apr 1;356:109847. doi: 10.1016/j.cbi.2022.109847. Epub 2022 Feb 9.
• [51] Prenatal ethanol exposure increases maternal bile acids through placental transport pathway. Toxicology. 2021 Jun 30;458:152848. doi: 10.1016/j.tox.2021.152848. Epub 2021 Jul 2.
• [52] Serine 574 phosphorylation alters transcriptional programming of FOXO3 by selectively enhancing apoptotic gene expression. Cell Death Differ. 2016 Apr;23(4):583-95. doi: 10.1038/cdd.2015.125. Epub 2015 Oct 16.
• [53] The use of genomics technology to investigate gene expression changes in cultured human liver cells. Toxicol In Vitro. 2001 Aug-Oct;15(4-5):399-405. doi: 10.1016/s0887-2333(01)00043-1.
• [54] Silibinin inhibits ethanol- or acetaldehyde-induced ferroptosis in liver cell lines. Toxicol In Vitro. 2022 Aug;82:105388. doi: 10.1016/j.tiv.2022.105388. Epub 2022 May 18.
• [55] The resveratrol attenuates ethanol-induced hepatocyte apoptosis via inhibiting ER-related caspase-12 activation and PDE activity in vitro. Alcohol Clin Exp Res. 2014 Mar;38(3):683-93. doi: 10.1111/acer.12311. Epub 2013 Nov 13.
• [56] Deletion of circadian gene Per1 alleviates acute ethanol-induced hepatotoxicity in mice. Toxicology. 2013 Dec 15;314(2-3):193-201. doi: 10.1016/j.tox.2013.09.009. Epub 2013 Oct 18.
• [57] Critical role of FoxO3a in alcohol-induced autophagy and hepatotoxicity. Am J Pathol. 2013 Dec;183(6):1815-1825. doi: 10.1016/j.ajpath.2013.08.011. Epub 2013 Oct 1.
• [58] Prenatal ethanol exposure-induced a low level of foetal blood cholesterol and its mechanism of IGF1-related placental cholesterol transport dysfunction. Toxicology. 2019 Aug 1;424:152237. doi: 10.1016/j.tox.2019.152237. Epub 2019 Jun 18.
• [59] Use of transcriptomics in hazard identification and next generation risk assessment: A case study with clothianidin. Food Chem Toxicol. 2022 Aug;166:113212. doi: 10.1016/j.fct.2022.113212. Epub 2022 Jun 8.
• [60] Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC). Front Microbiol. 2015 Dec 22;6:1452. doi: 10.3389/fmicb.2015.01452. eCollection 2015.
• [61] Metal-catalyzed oxidation of human growth hormone: modulation by solvent-induced changes of protein conformation. J Pharm Sci. 2001 Jan;90(1):58-69. doi: 10.1002/1520-6017(200101)90:1<58::aid-jps7>3.0.co;2-w.
• [62] Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation. Toxicology. 2021 Sep;461:152923. doi: 10.1016/j.tox.2021.152923. Epub 2021 Aug 30.
• [63] Acanthoic acid protectsagainst ethanol-induced liver injury: Possible role of AMPK activation and IRAK4 inhibition. Toxicol Lett. 2017 Nov 5;281:127-138. doi: 10.1016/j.toxlet.2017.09.020. Epub 2017 Sep 28.
• [64] Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats. Toxicol Lett. 2017 Feb 5;267:1-10. doi: 10.1016/j.toxlet.2016.12.010. Epub 2016 Dec 15.
• [65] Comparison of replicative senescence and stress-induced premature senescence combining differential display and low-density DNA arrays. FEBS Lett. 2005 Jul 4;579(17):3651-9. doi: 10.1016/j.febslet.2005.05.056.
• [66] Analysis of the effects of different alcohols on MCF-7 human breast cancer cells. Ann N Y Acad Sci. 2004 Dec;1030:78-85. doi: 10.1196/annals.1329.010.
• [67] Ethanol decreases the efficiency of phosphorylation of thymidine kinase in a human T-lymphocytic cell line. Alcohol Clin Exp Res. 2002 Mar;26(3):295-302.
• [68] Positive signaling interactions between arsenic and ethanol for angiogenic gene induction in human microvascular endothelial cells. Toxicol Sci. 2008 Apr;102(2):319-27. doi: 10.1093/toxsci/kfn003. Epub 2008 Jan 8.
• [69] NCX3 alleviates ethanol-induced apoptosis of SK-N-SH cells via the elimination of intracellular calcium ions. Toxicol In Vitro. 2021 Apr;72:105104. doi: 10.1016/j.tiv.2021.105104. Epub 2021 Jan 28.
• [70] Oxidative stress-mediated up-regulation of ABC transporters in lung cancer cells. J Biochem Mol Toxicol. 2022 Aug;36(8):e23095. doi: 10.1002/jbt.23095. Epub 2022 May 9.
• [71] Ethanol and acetone stimulate the proliferation of HaCaT keratinocytes: the possible role of alcohol in exacerbating psoriasis. Arch Dermatol Res. 2003 Jun;295(2):56-62. doi: 10.1007/s00403-003-0399-2. Epub 2003 Apr 26.
• [72] Gallic acid protects against ethanol-induced hepatocyte necroptosis via an NRF2-dependent mechanism. Toxicol In Vitro. 2019 Jun;57:226-232. doi: 10.1016/j.tiv.2019.03.008. Epub 2019 Mar 7.
• [73] Hepatoprotective effect of lucidone against alcohol-induced oxidative stress in human hepatic HepG2 cells through the up-regulation of HO-1/Nrf-2 antioxidant genes. Toxicol In Vitro. 2012 Aug;26(5):700-8. doi: 10.1016/j.tiv.2012.03.012. Epub 2012 Mar 30.
• [74] Ethanol enhances susceptibility to apoptotic cell death via down-regulation of autophagy-related proteins. Alcohol Clin Exp Res. 2011 Aug;35(8):1381-91. doi: 10.1111/j.1530-0277.2011.01473.x. Epub 2011 Mar 15.
• [75] miR-497 and miR-302b regulate ethanol-induced neuronal cell death through BCL2 protein and cyclin D2. J Biol Chem. 2011 Oct 28;286(43):37347-57. doi: 10.1074/jbc.M111.235531. Epub 2011 Aug 30.
• [76] Induction of alcohol-metabolizing enzymes and heat shock protein expression by ethanol and modulation by fenugreek seed polyphenols in Chang liver cells. Toxicol Mech Methods. 2009 Feb;19(2):116-22. doi: 10.1080/15376510802305039.
• [77] Induction of Sestrin2 by pterostilbene suppresses ethanol-triggered hepatocyte senescence by degrading CCN1 via p62-dependent selective autophagy. Cell Biol Toxicol. 2023 Jun;39(3):729-749. doi: 10.1007/s10565-021-09635-8. Epub 2021 Aug 17.
• [78] Role of MCP-1 in alcohol-induced aggressiveness of colorectal cancer cells. Mol Carcinog. 2016 May;55(5):1002-11. doi: 10.1002/mc.22343. Epub 2015 May 25.
• [79] A Chip for Estrogen Receptor Action: Detection of Biomarkers Released by MCF-7 Cells through Estrogenic and Anti-Estrogenic Effects. Sensors (Basel). 2017 Aug 1;17(8):1760. doi: 10.3390/s17081760.
• [80] Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects. Int J Mol Sci. 2015 Jan 5;16(1):1008-29. doi: 10.3390/ijms16011008.
• [81] Ethanol directly induced HMGB1 release through NOX2/NLRP1 inflammasome in neuronal cells. Toxicology. 2015 Aug 6;334:104-10. doi: 10.1016/j.tox.2015.06.006. Epub 2015 Jun 12.
• [82] Discovery of Ezrin Expression as a Potential Biomarker for Chemically Induced Ocular Irritation Using Human Corneal Epithelium Cell Line and a Reconstructed Human Cornea-like Epithelium Model. Toxicol Sci. 2018 Oct 1;165(2):335-346. doi: 10.1093/toxsci/kfy134.
• [83] Acute and chronic effects of some dietary bioactive compounds on folic acid uptake and on the expression of folic acid transporters by the human trophoblast cell line BeWo. J Nutr Biochem. 2008 Feb;19(2):91-100. doi: 10.1016/j.jnutbio.2007.01.007. Epub 2007 May 24.
• [84] Heme oxygenase-1 and interleukin-11 are overexpressed in stress-induced premature senescence of human WI-38 fibroblasts induced by tert-butylhydroperoxide and ethanol. Biogerontology. 2007 Aug;8(4):409-22. doi: 10.1007/s10522-007-9084-8. Epub 2007 Feb 13.
• [85] Heparin binding epidermal growth factor-like growth factor reduces ethanol-induced apoptosis and differentiation in human embryonic stem cells. Growth Factors. 2009 Dec;27(6):362-9. doi: 10.3109/08977190903159953.
• [86] Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner. Toxicol Appl Pharmacol. 2017 Jan 15;315:23-34. doi: 10.1016/j.taap.2016.12.001. Epub 2016 Dec 6.
• [87] Low ethanol concentration alters CHRNA5 RNA levels during early human development. Reprod Toxicol. 2010 Nov;30(3):489-92. doi: 10.1016/j.reprotox.2010.04.011. Epub 2010 May 11.
• [88] Alcohol inhibits cell-cell adhesion mediated by human L1. J Cell Biol. 1996 Apr;133(2):381-90. doi: 10.1083/jcb.133.2.381.
• [89] Ethanol disrupts vascular endothelial barrier: implication in cancer metastasis. Toxicol Sci. 2012 May;127(1):42-53. doi: 10.1093/toxsci/kfs087. Epub 2012 Feb 13.
• [90] Folic acid uptake by the human syncytiotrophoblast: interference by pharmacotherapy, drugs of abuse and pathological conditions. Reprod Toxicol. 2009 Dec;28(4):511-20. doi: 10.1016/j.reprotox.2009.07.001. Epub 2009 Jul 16.
• [91] Ethanol-induced expression of glutamate-cysteine ligase catalytic subunit gene is mediated by NF-kappaB. Toxicol Lett. 2009 Mar 10;185(2):110-5. doi: 10.1016/j.toxlet.2008.12.006. Epub 2008 Dec 14.
• [92] The potential effects of HECTD4 variants on fasting glucose and triglyceride levels in relation to prevalence of type 2 diabetes based on alcohol intake. Arch Toxicol. 2022 Sep;96(9):2487-2499. doi: 10.1007/s00204-022-03325-y. Epub 2022 Jun 17.
• [93] Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J Biol Chem. 2006 Aug 11;281(32):22974-82. doi: 10.1074/jbc.M602098200. Epub 2006 May 31.
• [94] Ethanol impairs intestinal barrier function in humans through mitogen activated protein kinase signaling: a combined in vivo and in vitro approach. PLoS One. 2014 Sep 16;9(9):e107421. doi: 10.1371/journal.pone.0107421. eCollection 2014.
• [95] Methyl ferulic acid attenuates ethanol-induced hepatic steatosis by regulating AMPK and FoxO1 Pathways in Rats and L-02 cells. Chem Biol Interact. 2018 Aug 1;291:180-189. doi: 10.1016/j.cbi.2018.06.028. Epub 2018 Jun 27.
• [96] Inhibition of store-operated Ca(2+) channels prevent ethanol-induced intracellular Ca(2+) increase and cell injury in a human hepatoma cell line. Toxicol Lett. 2012 Feb 5;208(3):254-61. doi: 10.1016/j.toxlet.2011.11.007. Epub 2011 Nov 17.
• [97] The significance of Runx2 mediating alcohol-induced Brf1 expression and RNA Pol III gene transcription. Chem Biol Interact. 2020 May 25;323:109057. doi: 10.1016/j.cbi.2020.109057. Epub 2020 Mar 18.
• [98] Alcohol-induced blood-brain barrier dysfunction is mediated via inositol 1,4,5-triphosphate receptor (IP3R)-gated intracellular calcium release. J Neurochem. 2007 Jan;100(2):324-36. doi: 10.1111/j.1471-4159.2006.04245.x.
• [99] Oxidative stress-dependent frataxin inhibition mediated alcoholic hepatocytotoxicity through ferroptosis. Toxicology. 2020 Dec 1;445:152584. doi: 10.1016/j.tox.2020.152584. Epub 2020 Oct 2.
• [100] Alcohol induces DNA damage and the Fanconi anemia D2 protein implicating FANCD2 in the DNA damage response pathways in brain. Alcohol Clin Exp Res. 2008 Jul;32(7):1186-96. doi: 10.1111/j.1530-0277.2008.00673.x.
• [101] Modulation of Atg5 expression by globular adiponectin contributes to autophagy flux and suppression of ethanol-induced cell death in liver cells. Food Chem Toxicol. 2014 Jun;68:11-22. doi: 10.1016/j.fct.2014.02.027. Epub 2014 Feb 27.
• [102] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [103] Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans. Am J Med Genet B Neuropsychiatr Genet. 2003 Jul 1;120B(1):97-108. doi: 10.1002/ajmg.b.20034.
• [104] NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice. Neuropsychopharmacology. 2006 Mar;31(3):572-84. doi: 10.1038/sj.npp.1300855.
• [105] Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet. 2012 Dec;44(12):1349-54. doi: 10.1038/ng.2466. Epub 2012 Nov 11.
• [106] L1 coupling to ankyrin and the spectrin-actin cytoskeleton modulates ethanol inhibition of L1 adhesion and ethanol teratogenesis. FASEB J. 2018 Mar;32(3):1364-1374. doi: 10.1096/fj.201700970. Epub 2018 Jan 3.
• [107] Embryonic catalase protects against ethanol-initiated DNA oxidation and teratogenesis in acatalasemic and transgenic human catalase-expressing mice. Toxicol Sci. 2013 Aug;134(2):400-11. doi: 10.1093/toxsci/kft122. Epub 2013 Jun 2.
• [108] The LRP6 functional mutation rs2302685 contributes to individual susceptibility to alcoholic liver injury related to the Wnt/-catenin-TCF1-CYP2E1 signaling pathway. Arch Toxicol. 2019 Jun;93(6):1679-1695. doi: 10.1007/s00204-019-02447-0. Epub 2019 Apr 11.
• [109] A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs. Pharmacogenet Genomics. 2008 Feb;18(2):99-107. doi: 10.1097/FPC.0b013e3282f3ef9c.
• [110] Substance dependence low-density whole genome association study in two distinct American populations. Hum Genet. 2008 Jun;123(5):495-506. doi: 10.1007/s00439-008-0501-0. Epub 2008 Apr 26.
• [111] Polymorphisms of the glutathione S-transferases mu-1 (GSTM1) and theta-1 (GSTT1) and the risk of advanced alcoholic liver disease. Scand J Gastroenterol. 2005 Mar;40(3):348-53. doi: 10.1080/00365520510012109.
• [112] Association of PER2 genotype and stressful life events with alcohol drinking in young adults. PLoS One. 2013;8(3):e59136. doi: 10.1371/journal.pone.0059136. Epub 2013 Mar 22.
• [113] Overexpression of the human DEK oncogene reprograms cellular metabolism and promotes glycolysis. PLoS One. 2017 May 30;12(5):e0177952. doi: 10.1371/journal.pone.0177952. eCollection 2017.
• [114] Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. Nat Genet. 2015 May;47(5):505-511. doi: 10.1038/ng.3252. Epub 2015 Mar 30.
• [115] Lidocaine prevents breast cancer growth by targeting neuronatin to inhibit nerve fibers formation. J Toxicol Sci. 2021;46(7):329-339. doi: 10.2131/jts.46.329.
• [116] Mechanisms of analgesia of intravenous lidocaine. Rev Bras Anestesiol. 2008 May-Jun;58(3):280-6.
• [117] Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
• [118] Pharmacokinetics of lidocaine hydrochloride metabolized by CYP3A4 in Chinese Han volunteers living at low altitude and in native Han and Tibetan Chinese volunteers living at high altitude. Pharmacology. 2016;97(3-4):107-13.
• [119] Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
• [120] Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos. 2000 Aug;28(8):959-65.
• [121] Drug Interactions Flockhart Table
• [122] Insights into CYP2B6-mediated drug-drug interactions. Acta Pharm Sin B. 2016 Sep;6(5):413-425.
• [123] The effect of mild and moderate hepatic impairment on the pharmacokinetics of valdecoxib, a selective COX-2 inhibitor. Eur J Clin Pharmacol. 2005 Jun;61(4):247-56.
• [124] Evidence of significant contribution from CYP3A5 to hepatic drug metabolism. Drug Metab Dispos. 2004 Dec;32(12):1434-45. doi: 10.1124/dmd.104.001313. Epub 2004 Sep 21.
• [125] Binding of disopyramide, methadone, dipyridamole, chlorpromazine, lignocaine and progesterone to the two main genetic variants of human alpha 1-acid glycoprotein: evidence for drug-binding differences between the variants and for the presence of two separate drug-binding sites on alpha 1-acid glycoprotein. Pharmacogenetics. 1996 Oct;6(5):403-15. doi: 10.1097/00008571-199610000-00004.
• [126] Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry. Odontology. 2013 Jan;101(1):43-51.
• [127] Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. Toxicol Lett. 2015 Jan 5;232(1):193-202. doi: 10.1016/j.toxlet.2014.10.009. Epub 2014 Oct 16.
• [128] Effects of capsaicin, bradykinin and prostaglandin E2 in the human skin. Br J Dermatol. 1992 Feb;126(2):111-7. doi: 10.1111/j.1365-2133.1992.tb07806.x.
• [129] [Influence of lidocaine on systemic inflammation in perioperative patients undergoing cardiopulmonary bypass]. Beijing Da Xue Xue Bao Yi Xue Ban. 2005 Dec 18;37(6):622-4.
• [130] Apoptosis and mitochondrial dysfunction in human chondrocytes following exposure to lidocaine, bupivacaine, and ropivacaine. J Bone Joint Surg Am. 2010 Mar;92(3):609-18. doi: 10.2106/JBJS.H.01847.
• [131] Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicol Sci. 2013 Dec;136(2):581-94. doi: 10.1093/toxsci/kft205. Epub 2013 Sep 19.
• [132] The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons. J Clin Invest. 2008 Feb;118(2):763-76. doi: 10.1172/JCI32751.
• [133] Studies on sulfation of synthesized metabolites from the local anesthetics ropivacaine and lidocaine using human cloned sulfotransferases. Drug Metab Dispos. 1999 Sep;27(9):1057-63.
• [134] H(1)R mediates local anesthetic-induced vascular permeability in angioedema. Toxicol Appl Pharmacol. 2020 Apr 1;392:114921. doi: 10.1016/j.taap.2020.114921. Epub 2020 Feb 12.
• [135] Lidocaine-induced Brugada syndrome phenotype linked to a novel double mutation in the cardiac sodium channel. Circ Res. 2008 Aug 15;103(4):396-404. doi: 10.1161/CIRCRESAHA.108.172619. Epub 2008 Jul 3.