General Information of Disease (ID: DIS485QZ)

Disease Name Fatty liver disease
Synonyms hepatic lipidosis; steatosis of liver; fatty liver; fatty change of liver
Disease Class DB92: Non-alcoholic fatty liver disease
Definition A reversible condition wherein large vacuoles of triglyceride fat accumulate in liver cells via the process of steatosis.|Editor note: classified as inherited in DO
Disease Hierarchy
DISWD40R: Disease
DIS2OMMF: Liver disease
DIS485QZ: Fatty liver disease
ICD Code
ICD-11
ICD-11: DB92.Z
Expand ICD-11
'DB92.Z
Disease Identifiers
MONDO ID
MONDO_0004790
MESH ID
D005234
UMLS CUI
C2711227
MedGen ID
398225
HPO ID
HP:0001397
SNOMED CT ID
197321007

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
MB-11055 DM3RBJW Phase 2 NA [1]
JKB-121 DMN2PF6 Phase 1/2 NA [2]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
ASO-1 DM87VR8 Investigative NA [3]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 252 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ANPEP TTPHMWB Limited Biomarker [4]
APOE TTKS9CB Limited Biomarker [5]
ATF4 TTQCKWT Limited Altered Expression [6]
BCL2A1 TTGT9C7 Limited Biomarker [7]
CAT TTPS279 Limited Altered Expression [8]
CNR2 TTMSFAW Limited Genetic Variation [9]
CXCR6 TT2BVUA Limited Biomarker [10]
CYP19A1 TTSZLWK Limited Biomarker [11]
EIF2AK3 TT79U1M Limited Altered Expression [6]
ELANE TTPLTSQ Limited Altered Expression [12]
FAT1 TTGUJYV Limited Biomarker [13]
FFAR1 TTB8FUC Limited Biomarker [14]
FFAR4 TT08JVB Limited Biomarker [15]
GCK TTDLNGZ Limited Altered Expression [16]
IRF3 TTYR7OH Limited Biomarker [17]
IRS1 TTAJSQ0 Limited Posttranslational Modification [18]
IRS2 TTF95B8 Limited Altered Expression [19]
KHK TTPAFR9 Limited Biomarker [20]
LDLR TTH0DUS Limited Altered Expression [21]
LRP1 TTF2V7I Limited Biomarker [22]
MC4R TTD0CIQ Limited Genetic Variation [23]
NAMPT TTD1WIG Limited Altered Expression [24]
P2RX7 TT473XN Limited Biomarker [25]
SIRT3 TTVZLIJ Limited Altered Expression [26]
SMPD1 TTJTM88 Limited Biomarker [27]
TPH1 TTZSJHV Limited Biomarker [28]
TRPV1 TTMI6F5 Limited Biomarker [8]
ATP7B TTOPO51 moderate Biomarker [29]
LIPA TTS8T1M moderate Biomarker [30]
UBE3A TTUZX6V moderate Biomarker [31]
ABCA1 TTJW1GN Strong Altered Expression [32]
ABCB11 TTUXCAF Strong Biomarker [33]
ABCG1 TTMWDGU Strong Altered Expression [34]
ACE2 TTUI5H7 Strong Biomarker [35]
ACLY TT0Z6Y2 Strong Biomarker [36]
ACVR2B TTLFRKS Strong Genetic Variation [37]
ADAMTS13 TTUREBK Strong Biomarker [38]
ADRB3 TTMXGCW Strong Biomarker [39]
AFP TTCFEA1 Strong Biomarker [40]
AHCY TTE2KUJ Strong Genetic Variation [41]
AHSG TTKF4WV Strong Biomarker [42]
AKR1B1 TTFBNVI Strong Biomarker [43]
AKT2 TTH24WI Strong Biomarker [44]
ALDH2 TTFLN4T Strong Genetic Variation [45]
ANGPTL4 TTWALY5 Strong Biomarker [46]
AOX1 TT3MOS2 Strong Biomarker [47]
APLN TT87D3J Strong Biomarker [48]
APOA1 TT5S8DR Strong Altered Expression [49]
APOA4 TTNC3WS Strong Altered Expression [50]
APOB TTN1IE2 Strong Genetic Variation [51]
AQP7 TTNGCRK Strong Altered Expression [52]
AQP9 TTQEI32 Strong Altered Expression [53]
ATIC TT9NVXQ Strong Biomarker [54]
BCL6 TTC9YX5 Strong Biomarker [55]
BIRC3 TTAIWZN Strong Biomarker [56]
BLVRA TTJBPN3 Strong Biomarker [57]
BRD1 TTT09OB Strong Biomarker [58]
C3AR1 TTI6B3F Strong Biomarker [59]
CA3 TTXUK5D Strong Altered Expression [60]
CASP1 TTCQIBE Strong Altered Expression [61]
CASP2 TT12VNG Strong Biomarker [62]
CAV1 TTXUBN2 Strong Biomarker [63]
CBS TTVZJ7G Strong Biomarker [64]
CCL2 TTNAY0P Strong Biomarker [65]
CCR2 TTFZYTO Strong Biomarker [66]
CEBPB TTUI35N Strong Altered Expression [67]
CES1 TTMF541 Strong Biomarker [68]
CETP TTFQAYR Strong Altered Expression [69]
CFB TTA0P7K Strong Biomarker [70]
CFD TT8D13I Strong Biomarker [71]
CFLAR TTJZQYH Strong Biomarker [72]
CFP TTLA0VS Strong Biomarker [71]
CHIT1 TTDYX6T Strong Biomarker [73]
CHUK TT1F8OQ Strong Genetic Variation [74]
CMKLR1 TT4UGZL Strong Altered Expression [75]
CNTF TTGEM5Q Strong Biomarker [76]
CPS1 TT42M75 Strong Altered Expression [77]
CPT1B TTDL0NY Strong Altered Expression [78]
CRP TTWRN6M Strong Altered Expression [79]
CRTC1 TT4GO0F Strong Biomarker [80]
CS TTZA6B3 Strong Altered Expression [81]
CTF1 TTXGTZU Strong Biomarker [82]
CTSA TT5NILS Strong Altered Expression [83]
CTSD TTPT2QI Strong Biomarker [84]
CYP1B1 TTI84H7 Strong Therapeutic [85]
CYP2A6 TTAQ6ZW Strong Biomarker [86]
CYP3A4 TTWP7HQ Strong Biomarker [87]
DAPK3 TTERVQN Strong Biomarker [88]
DEPTOR TTLYP6D Strong Biomarker [89]
DGAT1 TT0GV3R Strong Biomarker [90]
DGAT2 TTRHEQ4 Strong Biomarker [91]
DPP4 TTDIGC1 Strong Biomarker [92]
DYRK3 TTV4EX0 Strong Biomarker [93]
EHMT1 TTOFXD7 Strong Biomarker [94]
EIF2AK4 TT9U4EP Strong Biomarker [95]
EPHB6 TTZEMUY Strong Genetic Variation [96]
ERN1 TTKIAT3 Strong Biomarker [97]
F2 TT6L509 Strong Biomarker [98]
F2R TTL935N Strong Biomarker [99]
FABP1 TTIV96N Strong Altered Expression [100]
FABP5 TTNT2S6 Strong Biomarker [7]
FADS2 TTT2VDU Strong Biomarker [101]
FAP TTGPQ0F Strong Biomarker [92]
FASN TT7AOUD Strong Biomarker [102]
FBXO3 TTUX14L Strong Biomarker [103]
FDFT1 TTFQEO5 Strong Genetic Variation [104]
FFAR2 TT0FYAN Strong Altered Expression [105]
FGF19 TTGCH11 Strong Biomarker [106]
FGF21 TTQ916P Strong Biomarker [106]
FGF23 TT2IZ4K Strong Altered Expression [107]
FOLR2 TTT54CI Strong Biomarker [108]
FOS TTOM5AU Strong Biomarker [109]
FOXO1 TTLRVIA Strong Biomarker [110]
FPR1 TT5Y4EM Strong Biomarker [111]
FSTL3 TTWRPM8 Strong Biomarker [112]
FZD7 TTUQMO5 Strong Altered Expression [113]
G6PC TTBQMJ8 Strong Altered Expression [114]
GCG TT6Y4PN Strong Biomarker [115]
GCGR TT9O6WS Strong Biomarker [116]
GCLM TTNFESW Strong Genetic Variation [117]
GGH TTZJRL0 Strong Altered Expression [118]
GHR TTHJWYD Strong Altered Expression [119]
GHSR TTWDC17 Strong Biomarker [120]
GIP TT40HS5 Strong Biomarker [121]
GIPR TTYMKBE Strong Biomarker [122]
GLP1R TTVIMDE Strong Biomarker [94]
GLP2R TT1YWO5 Strong Altered Expression [123]
GLRX TTRJCNG Strong Biomarker [124]
GPBAR1 TTSDVTR Strong Biomarker [125]
GPR119 TT7QNVC Strong Biomarker [92]
GPR35 TT254XD Strong Biomarker [126]
GPX1 TTYAHBP Strong Biomarker [127]
HDAC3 TT4YWTO Strong Biomarker [128]
HDAC5 TTUELN5 Strong Genetic Variation [129]
HNF1A TT01M3K Strong Biomarker [130]
HNRNPA1 TTPJ9XK Strong Biomarker [131]
HSD11B1 TTN7BL9 Strong Biomarker [132]
HSPA8 TTMQL3K Strong Biomarker [4]
HTR1B TTK8CXU Strong Biomarker [133]
HTR2A TTJQOD7 Strong Biomarker [28]
HTR2B TT0K1SC Strong Biomarker [133]
ICOSLG TTB9Z8R Strong Biomarker [134]
IFNAR1 TTSYFMA Strong Altered Expression [135]
IKBKB TTJ3E9X Strong Biomarker [35]
IL11RA TTZPLJS Strong Biomarker [136]
IL13RA2 TTMPZ7V Strong Altered Expression [137]
INS TTZOPHG Strong Biomarker [138]
INSR TTCBFJO Strong Biomarker [139]
ITGA1 TTPERWV Strong Biomarker [140]
ITPR2 TTK9OV3 Strong Altered Expression [141]
KHDRBS1 TTAT6C7 Strong Biomarker [142]
KLB TTARBVH Strong Biomarker [143]
LALBA TTBRLU3 Strong Biomarker [144]
LAMP1 TTC214J Strong Biomarker [145]
LAPTM4B TTEJQT0 Strong Biomarker [146]
LBP TTVQJLY Strong Altered Expression [147]
LCN2 TTKTLAI Strong Biomarker [148]
LEP TTBJEZ5 Strong Altered Expression [149]
LEPR TT0HD6V Strong Biomarker [115]
LIPE TTLUQ8E Strong Altered Expression [150]
LNPEP TTY2KP7 Strong Biomarker [151]
LTF TTSZDQU Strong Biomarker [152]
MADCAM1 TTBD6I7 Strong Biomarker [153]
MAP3K5 TTOQCD8 Strong Altered Expression [154]
MAP3K7 TTJQT60 Strong Biomarker [155]
MAP3K8 TTGECUM Strong Altered Expression [156]
MAS1 TTOISYB Strong Biomarker [157]
MCHR1 TTX4RTB Strong Biomarker [158]
MLYCD TT9Z4YD Strong Biomarker [159]
MSTN TTM8I2X Strong Genetic Variation [160]
MUC1 TTBHFYQ Strong Biomarker [159]
MYC TTNQ5ZP Strong Therapeutic [161]
NFE2L2 TTA6ZN2 Strong Altered Expression [162]
NLRC5 TTWZC78 Strong Altered Expression [163]
NLRX1 TTKT026 Strong Biomarker [164]
NPC1L1 TTPD1CN Strong Biomarker [165]
NPPC TTRK0B9 Strong Biomarker [166]
NR1D1 TTAD1O8 Strong Biomarker [167]
NR1H3 TTECBXN Strong Biomarker [168]
NR1H4 TTS4UGC Strong Biomarker [162]
NR1I2 TT7LCTF Strong Biomarker [169]
NRG4 TTWAGKJ Strong Biomarker [170]
OTC TT5KIO9 Strong Genetic Variation [77]
PDGFC TTOABM9 Strong Biomarker [171]
PGRMC1 TTY3LAZ Strong Biomarker [172]
PLIN1 TTIV27N Strong Biomarker [173]
PNPLA6 TTWAQU2 Strong Biomarker [174]
POMC TT21AKM Strong Biomarker [175]
PON1 TT9LX82 Strong Altered Expression [176]
PPARD TT2JWF6 Strong Biomarker [177]
PPID TTNAFOU Strong Biomarker [178]
PPIF TTRFQTB Strong Biomarker [178]
PRDX4 TTPBL9I Strong Biomarker [179]
PREP TTNGKET Strong Biomarker [180]
PRMT3 TTL4XSQ Strong Altered Expression [181]
PTEN TTXJ3W7 Strong Biomarker [139]
PTPN1 TTELIN2 Strong Biomarker [175]
RAPGEF3 TTOE7I0 Strong Biomarker [182]
RAPGEF4 TTOS63B Strong Biomarker [182]
RARA TTW38KT Strong Altered Expression [183]
RBP4 TT0C8BY Strong Biomarker [184]
RENBP TTZCG0Q Strong Biomarker [185]
RORA TT1TYN7 Strong Biomarker [186]
SCD TT6RIOV Strong Biomarker [187]
SERPINA1 TTA7UJC Strong Biomarker [188]
SERPINA6 TTJL8VG Strong Biomarker [189]
SERPINE1 TTTO43N Strong Biomarker [190]
SIK2 TTCUGZR Strong Altered Expression [191]
SIRT1 TTUF2HO Strong Altered Expression [192]
SIRT6 TTUXYWF Strong Biomarker [193]
SLC10A1 TTWZRY5 Strong Biomarker [194]
SLC10A2 TTPI1M5 Strong Biomarker [195]
SLC13A5 TTFIMH7 Strong Genetic Variation [196]
SLC1A2 TT2F078 Strong Genetic Variation [197]
SLC22A8 TTTQR47 Strong Biomarker [189]
SLC27A4 TT20AYF Strong Biomarker [198]
SLC3A2 TT5CZSM Strong Genetic Variation [199]
SLC7A11 TTBZMIO Strong Genetic Variation [200]
SOAT2 TTAK0IN Strong Biomarker [201]
SOCS3 TTI0ME6 Strong Altered Expression [109]
SOD1 TTP9K3Q Strong Genetic Variation [202]
SORT1 TTRX9AV Strong Biomarker [203]
SPHK2 TTCN0M9 Strong Biomarker [204]
SPTBN1 TTS9BDA Strong Biomarker [205]
SQSTM1 TTOT2RY Strong Biomarker [142]
SREBF2 TTRQ4AP Strong Posttranslational Modification [206]
STAR TTEI40H Strong Altered Expression [207]
STC2 TT4EFTR Strong Biomarker [208]
STS TTHM0R1 Strong Therapeutic [209]
SUCNR1 TT4FX9Y Strong Biomarker [210]
SYVN1 TT8XKYM Strong Genetic Variation [211]
TBK1 TTMP03S Strong Biomarker [212]
TBL1X TTAL6S1 Strong Altered Expression [213]
TBL1XR1 TTYXT16 Strong Altered Expression [213]
TF TT8WXAV Strong Biomarker [214]
THRB TTGER3L Strong Biomarker [215]
TIPARP TT2FRAN Strong Altered Expression [216]
TLR4 TTISGCA Strong Altered Expression [217]
TLR6 TTWRI8V Strong Altered Expression [218]
TLR8 TT8CWFK Strong Genetic Variation [219]
TNFSF13B TTWMIDN Strong Altered Expression [220]
TRIM24 TT9Q7AE Strong Biomarker [221]
TRIM27 TTTO3QN Strong Biomarker [142]
TXNIP TTTLDZK Strong Genetic Variation [222]
UCP1 TTI12YJ Strong Genetic Variation [223]
UCP2 TTSC2YM Strong Altered Expression [224]
UGCG TTPHEX3 Strong Altered Expression [225]
USP10 TT5IH09 Strong Biomarker [226]
VDAC1 TTAMKGB Strong Biomarker [227]
ZFP36L1 TT8QVJO Strong Biomarker [228]
CRTC2 TTFWETR Definitive Altered Expression [114]
SIK1 TT1H6LC Definitive Altered Expression [114]
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⏷ Show the Full List of 252 DTT(s)
This Disease Is Related to 8 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC22A5 DT3HUVD Limited Altered Expression [100]
ABCD1 DTKM9DZ Strong Biomarker [229]
SLC16A11 DTYT1WO Strong Genetic Variation [230]
SLC25A13 DTDSYAQ Strong Genetic Variation [231]
SLC27A2 DTXK9WA Strong Altered Expression [232]
SLC27A5 DT0TQS3 Strong Genetic Variation [233]
SLC2A2 DTUJPOL Strong Biomarker [201]
SLC39A14 DTZ6IJW Strong Altered Expression [234]
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⏷ Show the Full List of 8 DTP(s)
This Disease Is Related to 22 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
AKR1B10 DEP6GT1 Limited Altered Expression [235]
CYP7A1 DEDZRQ1 Limited Altered Expression [236]
ACOT13 DEMK5U6 Strong Biomarker [237]
AKR1A1 DED2FW3 Strong Altered Expression [238]
AKR1D1 DEVON3M Strong Altered Expression [239]
ALDH1A2 DEKN1H4 Strong Biomarker [235]
CES2 DETHCPD Strong Biomarker [240]
CYP4F3 DEFCMPI Strong Altered Expression [241]
CYP7B1 DE36TMY Strong Biomarker [242]
CYP8B1 DETL4WB Strong Biomarker [243]
DDAH1 DEY0TQC Strong Biomarker [244]
DHCR7 DEL7GFA Strong Genetic Variation [245]
DHRS7 DEEXSKI Strong Biomarker [189]
DIO3 DET89OV Strong Altered Expression [246]
FADS1 DE05S8C Strong Genetic Variation [247]
MAT1A DEQ6NC9 Strong Biomarker [248]
MSRA DEU2ZBY Strong Altered Expression [249]
NAT10 DEZV4AP Strong Altered Expression [250]
NMRK1 DENV24I Strong Altered Expression [251]
NNMT DECVGJ3 Strong Biomarker [252]
PCK1 DEPLH5Z Strong Altered Expression [253]
UGT2B4 DENUPDX Strong Biomarker [254]
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⏷ Show the Full List of 22 DME(s)
This Disease Is Related to 312 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ADIPOR1 OT65ZFZN Limited Biomarker [255]
ATP5IF1 OTQFD73H Limited Biomarker [189]
ATP8B1 OTALGS63 Limited Biomarker [256]
BMPER OTBYON4H Limited Biomarker [257]
CD5L OTPY4WQR Limited Biomarker [258]
CD68 OTOYEY3J Limited Altered Expression [259]
CIDEC OTMDZ56K Limited Altered Expression [260]
CPT1A OTI862QH Limited Biomarker [261]
CXCL16 OTD49T9R Limited Biomarker [10]
FGL1 OTT0QHQ1 Limited Biomarker [262]
FLII OT7G9JG6 Limited Biomarker [263]
GFER OTVK43OK Limited Biomarker [238]
LYPLAL1 OT8F2DCV Limited Genetic Variation [264]
MT1B OTUA4FFH Limited Genetic Variation [265]
NR2C2 OTDZWVOJ Limited Biomarker [266]
PPP1R3B OTVCRXEZ Limited Genetic Variation [267]
RABGEF1 OTWC3Z3R Limited Biomarker [268]
RETSAT OTC3AOPX Limited Biomarker [269]
SFRP5 OTLCVVSH Limited Biomarker [270]
TERF2IP OT3M5P3G Limited Biomarker [268]
TRAF3 OT5TQBGV Limited Biomarker [4]
FAM3C OTBR6U9G Disputed Altered Expression [271]
DLAT OT9LBJVN moderate Biomarker [272]
DNAJB9 OT38EQT6 moderate Biomarker [273]
IGF2BP2 OT4ZSEEE moderate Genetic Variation [274]
IMMP2L OT9WGAFD moderate Genetic Variation [274]
KMT2B OTMMAZQX moderate Biomarker [31]
SPPL3 OT2HLJF6 moderate Genetic Variation [274]
SYNPO OTICDJAB moderate Altered Expression [275]
AACS OTGGPR6J Strong Biomarker [276]
AADAC OT8VACT2 Strong Biomarker [277]
ABHD5 OTY829Z3 Strong Genetic Variation [278]
ACACA OT5CQPZY Strong Biomarker [7]
ACADVL OT50L4XB Strong Genetic Variation [279]
ACBD3 OTMYNY7A Strong Biomarker [280]
ACOT11 OTGPB0SM Strong Altered Expression [281]
ACOX1 OTM0A0DY Strong Altered Expression [282]
ACSL5 OT3L9XO3 Strong Altered Expression [283]
ADIPOR2 OT2HDTL8 Strong Biomarker [284]
AGGF1 OTA7U2T8 Strong Biomarker [285]
AIRE OTA7G1Y1 Strong Biomarker [286]
ALDH1A3 OT1C9NKQ Strong Biomarker [235]
ALMS1 OTW66JKS Strong CausalMutation [287]
ALOXE3 OT76J52A Strong Altered Expression [288]
AMFR OTQRX7LC Strong Altered Expression [289]
AMPD1 OTU17BCI Strong Altered Expression [290]
AMPD2 OTBS30JU Strong Altered Expression [290]
ANGPTL8 OTQFINCD Strong Biomarker [291]
APCDD1 OTV9AD0L Strong Biomarker [292]
APOC1 OTA58CED Strong Altered Expression [293]
APOC4 OTE8ZUXY Strong Altered Expression [294]
APOM OTI3FQQC Strong Biomarker [295]
AQP12A OTVEHDZ1 Strong Biomarker [296]
ARID4B OTYLPILE Strong Biomarker [297]
ARNT OTMSIEZY Strong Biomarker [298]
ART3 OT68OFVT Strong Biomarker [299]
ASPG OT5E2EKR Strong Biomarker [300]
ATF6 OTAFHAVI Strong Altered Expression [6]
ATRNL1 OTY5JUX2 Strong Altered Expression [250]
AWAT1 OT8OTY3E Strong Biomarker [91]
AZU1 OTHXU264 Strong Biomarker [301]
BAMBI OTCEJ8W5 Strong Biomarker [302]
BATF3 OTI61WXQ Strong Biomarker [303]
BCAP31 OTKSACR4 Strong Biomarker [304]
BCO2 OTP1L0BZ Strong Altered Expression [305]
BHMT OTYB6PXZ Strong Biomarker [306]
BID OTOSHSHU Strong Biomarker [307]
BNIP3 OT4SO7J4 Strong Biomarker [308]
BSCL2 OT73V6Y4 Strong Altered Expression [309]
C1QTNF5 OTLKU5I2 Strong Genetic Variation [310]
CAP1 OTYM8A2N Strong Biomarker [151]
CARD6 OTEI1PJ1 Strong Altered Expression [311]
CAVIN1 OTFO915U Strong Genetic Variation [312]
CCAR2 OTLUDG5T Strong Biomarker [313]
CCDC80 OTOZSYEM Strong Biomarker [314]
CCHCR1 OT22C116 Strong Biomarker [315]
CCL4 OT6B8P25 Strong Biomarker [316]
CCL4L2 OTDBSXOU Strong Biomarker [317]
CD2AP OTC76KQM Strong Biomarker [318]
CELF1 OT6JQ5RS Strong Genetic Variation [319]
CERS1 OT6EYRM3 Strong Biomarker [317]
CERS2 OTRAHYYP Strong Biomarker [317]
CERS6 OTOP4GV1 Strong Biomarker [320]
CHPT1 OT4FJ0K3 Strong Altered Expression [321]
CLNK OTOWK51S Strong Genetic Variation [322]
CMAS OTFQJG3C Strong Genetic Variation [323]
CNDP2 OTJR9436 Strong Biomarker [189]
COL3A1 OTT1EMLM Strong Biomarker [324]
CPT2 OTIN6G20 Strong Altered Expression [321]
CREB3 OT9617UO Strong Altered Expression [50]
CREB3L3 OTDMU3GP Strong Altered Expression [325]
CREBZF OTO3TOEU Strong Altered Expression [326]
CREG1 OTRHJ8HK Strong Biomarker [327]
CWF19L1 OTAMYTOW Strong Genetic Variation [74]
CYCS OTBFALJD Strong Biomarker [127]
DBP OTE0W7LN Strong Biomarker [315]
DCTN4 OTM7C943 Strong Biomarker [142]
DDIT3 OTI8YKKE Strong Biomarker [328]
DDOST OT39PDMS Strong Altered Expression [329]
DDX3X OTDO4TRX Strong Altered Expression [330]
DECR1 OTCDIR6X Strong Biomarker [331]
DEPP1 OTB36PHJ Strong Biomarker [332]
DHDDS OTVLYBUS Strong Biomarker [333]
DNAH8 OTGES2OU Strong Biomarker [334]
DNASE2 OT6RC1BL Strong Biomarker [201]
DNLZ OT48CG1W Strong Genetic Variation [96]
DUSP12 OT8WB1YB Strong Altered Expression [335]
DUSP26 OTI7WIYN Strong Posttranslational Modification [155]
ECD OT3L3PCU Strong Altered Expression [336]
EDA OTAKS5WS Strong Altered Expression [337]
EIF2B5 OTV3R4RB Strong Biomarker [338]
EIF2S1 OTM0GDTP Strong Genetic Variation [339]
EIF2S2 OTXF0B09 Strong Genetic Variation [339]
EIF2S3 OTARRES9 Strong Genetic Variation [339]
ELOVL5 OT375W1Z Strong Altered Expression [340]
ERFE OTSES1HA Strong Genetic Variation [310]
ERLIN1 OTUOOODY Strong Genetic Variation [74]
ETNPPL OTSXO9P6 Strong Altered Expression [341]
FAF2 OTE8CE2E Strong Biomarker [342]
FAM168B OT312DUH Strong Altered Expression [61]
FAM3B OTC2S91N Strong Biomarker [343]
FANK1 OT5641YJ Strong Biomarker [344]
FBL OTRODIE5 Strong Biomarker [345]
FETUB OT7V07NI Strong Biomarker [346]
FGF5 OTQXGHBY Strong Biomarker [347]
FNDC5 OT5CSK9X Strong Genetic Variation [348]
FOXA1 OTEBY0TD Strong Biomarker [349]
FUNDC2 OTY3TQM5 Strong Biomarker [350]
G0S2 OT8FL49L Strong Biomarker [351]
GAB2 OTBFN705 Strong Biomarker [352]
GABPA OT9YB2SA Strong Altered Expression [162]
GCKR OTSIWXGG Strong Genetic Variation [264]
GDF1 OTZ1VRBH Strong Biomarker [317]
GGTLC1 OTWJKUHQ Strong Biomarker [353]
GNMT OT0O2OQO Strong Biomarker [354]
GOLGA6A OTHU9MRX Strong Biomarker [355]
GOLM1 OTOZSV6O Strong Biomarker [356]
GPAM OTR1XD9B Strong Altered Expression [237]
GPD1L OTVLWW9T Strong Biomarker [189]
GPS2 OT065FSS Strong Biomarker [357]
GPX4 OTRAFFX2 Strong Biomarker [358]
GSDMD OTH39BKI Strong Biomarker [359]
GTF2H1 OTCRXC6B Strong Biomarker [142]
H6PD OTO7TNDD Strong Altered Expression [360]
HACD1 OTEC7EP7 Strong Biomarker [151]
HADHA OTO557N2 Strong Biomarker [361]
HADHB OT4Y1I62 Strong Biomarker [362]
HAS3 OTPM8IL8 Strong Biomarker [363]
HDLBP OTKDEEYX Strong Biomarker [301]
HEBP1 OTR9MPDX Strong Biomarker [301]
HHEX OTLIUVYX Strong Biomarker [349]
HM13 OTGEO1LP Strong Altered Expression [364]
HNF1B OTSYIC3T Strong Biomarker [365]
HSPA12A OTFOCDD6 Strong Biomarker [366]
HSPA1A OTKGIE76 Strong Biomarker [367]
HYOU1 OTBGBSOV Strong Biomarker [368]
IGFBP4 OT2HZRBD Strong Biomarker [112]
IGLL1 OTRTNVOG Strong Biomarker [369]
IK OTWSSXX0 Strong Biomarker [93]
IKBKG OTNWJWSD Strong Biomarker [370]
INSIG1 OTZF5X1D Strong Biomarker [371]
INTU OTXB13E6 Strong Biomarker [372]
IP6K1 OTKS4P2T Strong Biomarker [373]
IQGAP2 OTX2UA7P Strong Biomarker [374]
IRF2BP2 OTSSRRCA Strong Biomarker [375]
IRF6 OTKJ44EV Strong Biomarker [376]
IRGM OTKD3O5Z Strong Genetic Variation [377]
JAZF1 OTXTYSYD Strong Biomarker [378]
KCTD17 OTESMJSS Strong Altered Expression [379]
KDM4B OT5P1UPY Strong Biomarker [380]
KDM5D OTEKG0KD Strong Biomarker [381]
KDSR OTCIES3H Strong Genetic Variation [382]
KLF15 OTGMQMVR Strong Biomarker [383]
KLF6 OTQY9S7F Strong Biomarker [384]
KRT18 OTVLQFIP Strong Biomarker [385]
KRT23 OTQW6UAG Strong Biomarker [386]
LAMA1 OTQZMP86 Strong Altered Expression [56]
LAMP3 OTN0XL3W Strong Altered Expression [83]
LCOR OT1K7DKB Strong Altered Expression [387]
LECT2 OTSFZ9JD Strong Altered Expression [388]
LPIN1 OTQ75KF2 Strong Biomarker [389]
LSAMP OTYXVQX2 Strong Altered Expression [83]
MACROH2A1 OTV2DQDD Strong Biomarker [390]
MFRP OTHY9ZA5 Strong Biomarker [391]
MID1IP1 OTFCORJM Strong Biomarker [392]
MLKL OTDSLC81 Strong Altered Expression [393]
MLXIPL OTR9MLLW Strong Altered Expression [394]
MOGAT1 OTZP43K4 Strong Genetic Variation [395]
MPRIP OT5FV5NS Strong Genetic Variation [396]
MPST OTCDPH5D Strong Genetic Variation [397]
MTG1 OTC9U1LI Strong Biomarker [398]
MYOM2 OTD2UOXW Strong Genetic Variation [399]
NADK2 OT1I8GDE Strong Genetic Variation [400]
NCAN OT8OO6ZE Strong Altered Expression [401]
NCF2 OTAUW7L2 Strong Biomarker [402]
NCK2 OTUYPF55 Strong Biomarker [403]
ND3 OT1OC3K3 Strong Altered Expression [404]
ND6 OTG47B7B Strong Altered Expression [405]
NEIL1 OTHBU5DJ Strong Biomarker [406]
NOCT OTVSYP2D Strong Biomarker [407]
NOS1AP OTDFOBRU Strong Genetic Variation [408]
NPC1 OTRIPICX Strong Biomarker [409]
NR2E1 OTW47GKM Strong Biomarker [410]
NREP OT2AZPKK Strong Biomarker [189]
NRIP1 OTIZOJQV Strong Biomarker [411]
NTS OTPGDNQS Strong Biomarker [412]
NUCB2 OTHO6JWN Strong Biomarker [413]
NUDT11 OTFDXJA1 Strong Biomarker [286]
NUP62 OTMN63DH Strong Biomarker [142]
NUS1 OT4DQ82L Strong Biomarker [414]
OGT OT1Z1ZXE Strong Biomarker [415]
OPCML OT93PQ6Y Strong Altered Expression [113]
OR10A4 OTYYB8SY Strong Biomarker [416]
OR10J5 OTZ63UYL Strong Biomarker [417]
PACC1 OTKBS8CC Strong Biomarker [418]
PAPPA OTTTG9PG Strong Biomarker [112]
PAQR3 OTTKJ9Y4 Strong Genetic Variation [419]
PAQR7 OTIWX5AM Strong Biomarker [420]
PCK2 OTJ8LX4N Strong Altered Expression [421]
PCTP OTM36JXE Strong Biomarker [422]
PDIA3 OTHPQ0Q3 Strong Biomarker [423]
PDK4 OTCMHMBZ Strong Altered Expression [424]
PDLIM3 OTVXQC81 Strong Altered Expression [250]
PGLYRP2 OTF8319A Strong Biomarker [425]
PHLPP2 OTXB1OUI Strong Biomarker [379]
PIF1 OTUHKKVP Strong Biomarker [426]
PIK3R3 OTXGJ8N1 Strong Altered Expression [427]
PKNOX1 OTUDMNHX Strong Biomarker [428]
PLEKHO1 OTMVUQ9W Strong Biomarker [429]
PLIN2 OTRXJ9UN Strong Biomarker [282]
PLIN3 OT9ZA7MR Strong Biomarker [173]
PLIN5 OTV8G50L Strong Biomarker [430]
PLPPR4 OTBOWTC5 Strong Genetic Variation [431]
PNPLA2 OTR3ERMR Strong Altered Expression [432]
POC1A OTXAG4PL Strong Genetic Variation [433]
POLG OTDUCT04 Strong CausalMutation [434]
POTEF OTV3WXYE Strong Biomarker [96]
PPARGC1A OTHCDQ22 Strong Altered Expression [309]
PPM1K OTNZ4N4E Strong Altered Expression [435]
PPP1R15A OTYG179K Strong Biomarker [436]
PPP1R3G OTFXJK3V Strong Biomarker [437]
PQBP1 OTXCBEAH Strong Biomarker [438]
PRDM16 OT0BGA27 Strong Altered Expression [439]
PRM3 OT6574BF Strong Biomarker [440]
PSMA5 OT38E6Y1 Strong Biomarker [189]
PSME3 OTSTC4YY Strong Biomarker [441]
PTMA OT2W4T1M Strong Therapeutic [442]
RAB40B OTCA9ZF5 Strong Altered Expression [443]
RAC2 OTAOHFNH Strong Altered Expression [444]
RARRES1 OTETUPP5 Strong Altered Expression [445]
RBL1 OTDEBFYC Strong Biomarker [446]
RBM38 OTPO8EXU Strong Biomarker [447]
RCBTB1 OTAYELI8 Strong Biomarker [355]
REG3G OTLIUY8Z Strong Altered Expression [448]
REPIN1 OTVTPXNX Strong Biomarker [449]
RETN OTW5Z1NH Strong Biomarker [450]
RIPK3 OTL1D484 Strong Biomarker [451]
RLN2 OTY3OG71 Strong Biomarker [452]
RNF125 OTBD1Q3X Strong Biomarker [453]
RRM2B OTE8GBUR Strong Genetic Variation [454]
RTL1 OTOT33IM Strong Biomarker [455]
RTRAF OTJ6NVMW Strong Biomarker [338]
S100A16 OT3ERKQI Strong Altered Expression [456]
SAMM50 OTRYFYIU Strong Genetic Variation [457]
SARM1 OTEP4I5O Strong Biomarker [458]
SART1 OTHMOGO1 Strong Biomarker [459]
SDF2L1 OTE7JIO2 Strong Biomarker [460]
SELENBP1 OT3NZNTR Strong Biomarker [315]
SELENOP OT02B8IR Strong Altered Expression [461]
SERPINB6 OT7G55IK Strong Biomarker [151]
SESN3 OTJRY1Y5 Strong Biomarker [462]
SETMAR OTE2MIMZ Strong Biomarker [455]
SGMS2 OT3NHO99 Strong Altered Expression [463]
SHBG OTPWU5IW Strong Biomarker [464]
SHC1 OT1J5IRN Strong Biomarker [465]
SIAH1 OT29A838 Strong Altered Expression [466]
SIN3A OTM8OZWV Strong Biomarker [16]
SIRT7 OT5M4OT4 Strong Biomarker [467]
SLBP OTVYYQRT Strong Biomarker [301]
SLC25A47 OT5NGRWC Strong Altered Expression [468]
SLURP1 OT89YD2E Strong Biomarker [270]
SMOC2 OTK1EQ49 Strong Altered Expression [469]
SMURF1 OT5UIZR8 Strong Biomarker [470]
SNX10 OT05B7BT Strong Biomarker [83]
SORBS1 OTWH8762 Strong Biomarker [151]
SPX OTY3G4AR Strong Biomarker [471]
SRA1 OTYOGMTG Strong Genetic Variation [472]
SRI OT4R3EAC Strong Altered Expression [473]
STAM OT6X5RR1 Strong Altered Expression [474]
STAM2 OT9OBWPH Strong Biomarker [301]
STEAP4 OTFTLAEZ Strong Altered Expression [475]
STING1 OTDAP4G0 Strong Altered Expression [476]
STK25 OT4YPNTF Strong Biomarker [477]
SUGP1 OT7W0EB8 Strong Genetic Variation [401]
SULF1 OTJCNCO0 Strong Altered Expression [478]
SUV39H2 OTU0F4LL Strong Biomarker [479]
TBL1Y OTA0F7TM Strong Altered Expression [213]
TCF7 OT1ID822 Strong Genetic Variation [480]
TFEB OTJUJJQY Strong Biomarker [481]
TFF3 OTJJDRTU Strong Biomarker [482]
THEM5 OTS3UKDP Strong Biomarker [483]
TLCD3B OTM6EPUS Strong Altered Expression [320]
TMBIM1 OTE47B57 Strong Altered Expression [484]
TMEM127 OTYHUXC1 Strong Altered Expression [485]
TMEM199 OTU1GZOY Strong Biomarker [486]
TOLLIP OTYEO4NR Strong Biomarker [487]
TOR1AIP1 OTTG8MAK Strong Biomarker [4]
TPPP3 OTU8VUIG Strong Altered Expression [61]
TRIB1 OTPEO17G Strong Genetic Variation [488]
TRIM8 OTS6JFR0 Strong Biomarker [266]
TRPC4AP OTNJ9IFS Strong Biomarker [489]
TSN OTOFAQ2Z Strong Biomarker [490]
------------------------------------------------------------------------------------
⏷ Show the Full List of 312 DOT(s)

References

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18 The antipsychotics sulpiride induces fatty liver in rats via phosphorylation of insulin receptor substrate-1 at Serine 307-mediated adipose tissue insulin resistance.Toxicol Appl Pharmacol. 2018 Apr 15;345:66-74. doi: 10.1016/j.taap.2018.02.023. Epub 2018 Mar 15.
19 Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers.Int J Obes (Lond). 2018 Sep;42(9):1544-1555. doi: 10.1038/s41366-018-0062-9. Epub 2018 May 1.
20 High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism.Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3138-3143. doi: 10.1073/pnas.1713837115. Epub 2018 Mar 5.
21 Diet-induced hepatic steatosis abrogates cell-surface LDLR by inducing de novo PCSK9 expression in mice.J Biol Chem. 2019 Jun 7;294(23):9037-9047. doi: 10.1074/jbc.RA119.008094. Epub 2019 Apr 19.
22 Low-density lipoprotein receptor-related protein-1 dysfunction synergizes with dietary cholesterol to accelerate steatohepatitis progression.J Biol Chem. 2018 Jun 22;293(25):9674-9684. doi: 10.1074/jbc.RA118.001952. Epub 2018 May 11.
23 Canagliflozin, an SGLT2 inhibitor, attenuates the development of hepatocellular carcinoma in a mouse model of human NASH.Sci Rep. 2018 Feb 5;8(1):2362. doi: 10.1038/s41598-018-19658-7.
24 NAMPT overexpression alleviates alcohol-induced hepatic steatosis in mice.PLoS One. 2019 Feb 22;14(2):e0212523. doi: 10.1371/journal.pone.0212523. eCollection 2019.
25 Purinergic P2X7 receptor blockade mitigates alcohol-induced steatohepatitis and intestinal injury by regulating MEK1/2-ERK1/2 signaling and egr-1 activity.Int Immunopharmacol. 2019 Jan;66:52-61. doi: 10.1016/j.intimp.2018.11.012. Epub 2018 Nov 13.
26 Regulation of mitochondrial trifunctional protein modulates nonalcoholic fatty liver disease in mice.J Lipid Res. 2018 Jun;59(6):967-973. doi: 10.1194/jlr.M080952. Epub 2018 Mar 26.
27 Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis.Mol Metab. 2017 Mar 12;6(5):416-427. doi: 10.1016/j.molmet.2017.03.002. eCollection 2017 May.
28 Serotonin signals through a gut-liver axis to regulate hepatic steatosis.Nat Commun. 2018 Nov 16;9(1):4824. doi: 10.1038/s41467-018-07287-7.
29 Targeted inactivation of copper transporter Atp7b in hepatocytes causes liver steatosis and obesity in mice.Am J Physiol Gastrointest Liver Physiol. 2017 Jul 1;313(1):G39-G49. doi: 10.1152/ajpgi.00312.2016. Epub 2017 Apr 20.
30 Lysosomal Acid Lipase: Can it be a New Non-Invasive Serum Biomarker of Cryptogenic Liver Fibrosis and Cirrhosis?.Ann Hepatol. 2019 Jan-Feb;18(1):78-88. doi: 10.5604/01.3001.0012.7865.
31 UBE3A Suppresses Overnutrition-Induced Expression of the Steatosis Target Genes of MLL4 by Degrading MLL4.Hepatology. 2019 Mar;69(3):1122-1134. doi: 10.1002/hep.30284. Epub 2019 Feb 7.
32 Thioredoxin-1 promotes macrophage reverse cholesterol transport and protects liver from steatosis.Biochem Biophys Res Commun. 2019 Sep 3;516(4):1103-1109. doi: 10.1016/j.bbrc.2019.06.109. Epub 2019 Jul 4.
33 Liver Transplantation for Progressive Familial Intrahepatic Cholestasis.Ann Transplant. 2018 Sep 25;23:666-673. doi: 10.12659/AOT.909941.
34 News on the molecular regulation and function of hepatic low-density lipoprotein receptor and LDLR-related protein 1.Curr Opin Lipidol. 2017 Jun;28(3):241-247. doi: 10.1097/MOL.0000000000000411.
35 Angiotensin-converting enzyme 2 inhibits endoplasmic reticulum stress-associated pathway to preserve nonalcoholic fatty liver disease.Diabetes Metab Res Rev. 2019 May;35(4):e3123. doi: 10.1002/dmrr.3123. Epub 2019 Jan 10.
36 An allosteric mechanism for potent inhibition of human ATP-citrate lyase.Nature. 2019 Apr;568(7753):566-570. doi: 10.1038/s41586-019-1094-6. Epub 2019 Apr 3.
37 A soluble activin receptor type IIb prevents the effects of androgen deprivation on body composition and bone health.Endocrinology. 2010 Sep;151(9):4289-300. doi: 10.1210/en.2010-0134. Epub 2010 Jun 23.
38 ADAMTS13 deficiency promotes microthrombosis in a murine model of diet-induced liver steatosis.Thromb Haemost. 2017 Jan 5;117(1):19-26. doi: 10.1160/TH16-03-0195. Epub 2016 Sep 8.
39 Aldehyde dehydrogenase 2 and beta3-adrenergic receptor gene polymorphisms: their association with elevated liver enzymes and metabolic syndrome.Metabolism. 2003 Sep;52(9):1096-101. doi: 10.1016/s0026-0495(03)00183-5.
40 Unusual first presentation of a metabolic disorder.BMJ Case Rep. 2019 Mar 22;12(3):e226716. doi: 10.1136/bcr-2018-226716.
41 TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase.Development. 2009 Mar;136(5):865-75. doi: 10.1242/dev.027565.
42 Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein.J Pineal Res. 2018 Sep;65(2):e12493. doi: 10.1111/jpi.12493. Epub 2018 Apr 21.
43 Uric acid activates aldose reductase and the polyol pathway for endogenous fructose and fat production causing development of fatty liver in rats. J Biol Chem. 2019 Mar 15;294(11):4272-4281. doi: 10.1074/jbc.RA118.006158. Epub 2019 Jan 16.
44 Hepatic mTOR-AKT2-Insig2 signaling pathway contributes to the improvement of hepatic steatosis after Roux-en-Y Gastric Bypass in mice.Biochim Biophys Acta Mol Basis Dis. 2019 Mar 1;1865(3):525-534. doi: 10.1016/j.bbadis.2018.12.014. Epub 2018 Dec 15.
45 Slow-metabolizing ADH1B and inactive heterozygous ALDH2 increase vulnerability to fatty liver in Japanese men with alcohol dependence.J Gastroenterol. 2018 May;53(5):660-669. doi: 10.1007/s00535-017-1402-6. Epub 2017 Oct 23.
46 Serum Angiopoietin-like peptide 4 levels in patients with hepatic steatosis.Cytokine. 2018 Nov;111:496-499. doi: 10.1016/j.cyto.2018.05.030. Epub 2018 Jun 14.
47 Alleviation of fatty liver in a rat model by enhancing N(1)-methylnicotinamide bioavailability through aldehyde oxidase inhibition.Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):203-210. doi: 10.1016/j.bbrc.2018.11.008. Epub 2018 Nov 13.
48 Hepatic and cardiac beneficial effects of a long-acting Fc-apelin fusion protein in diet-induced obese mice.Diabetes Metab Res Rev. 2018 Jul;34(5):e2997. doi: 10.1002/dmrr.2997. Epub 2018 Mar 25.
49 Apolipoprotein A-I improves hepatic autophagy through the AMPK pathway.Biochimie. 2019 Oct;165:210-218. doi: 10.1016/j.biochi.2019.08.001. Epub 2019 Aug 8.
50 Human leucine zipper protein promotes hepatic steatosis via induction of apolipoprotein A-IV.FASEB J. 2017 Jun;31(6):2548-2561. doi: 10.1096/fj.201601227R. Epub 2017 Feb 28.
51 Clinical and biochemical characteristics of individuals with low cholesterol syndromes: Acomparison between familial hypobetalipoproteinemia and familial combined hypolipidemia.J Clin Lipidol. 2017 Sep-Oct;11(5):1234-1242. doi: 10.1016/j.jacl.2017.06.013. Epub 2017 Jun 24.
52 Long non-coding RNA NEAT1 promotes steatosis via enhancement of estrogen receptor alpha-mediated AQP7 expression in HepG2 cells.Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1782-1787. doi: 10.1080/21691401.2019.1604536.
53 Effects of Qutanhuoxue Decoction on AQP7 and AQP9 Expression in Nonalcoholic Fatty Liver Model Rats.Evid Based Complement Alternat Med. 2019 Jun 2;2019:5709626. doi: 10.1155/2019/5709626. eCollection 2019.
54 The influence of AICAR - direct activator of AMP-activated protein kinase (AMPK) - on liver proteome in apoE-knockout mice.Eur J Pharm Sci. 2017 Jun 15;104:406-416. doi: 10.1016/j.ejps.2017.04.021. Epub 2017 Apr 26.
55 Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis.Elife. 2019 Apr 15;8:e43922. doi: 10.7554/eLife.43922.
56 Liver transcriptional profile of atherosclerosis-related genes in human nonalcoholic fatty liver disease.Atherosclerosis. 2011 Oct;218(2):378-85. doi: 10.1016/j.atherosclerosis.2011.05.014. Epub 2011 May 18.
57 Biliverdin reductase and bilirubin in hepatic disease.Am J Physiol Gastrointest Liver Physiol. 2018 Jun 1;314(6):G668-G676. doi: 10.1152/ajpgi.00026.2018. Epub 2018 Mar 1.
58 Effect of oleic acid on induction of steatosis and cytotoxicity in BRL 3A cells.J Cell Biochem. 2019 Dec;120(12):19541-19554. doi: 10.1002/jcb.29262. Epub 2019 Jul 1.
59 Bone marrow-derived macrophage contributes to fibrosing steatohepatitis through activating hepatic stellate cells.J Pathol. 2019 Aug;248(4):488-500. doi: 10.1002/path.5275. Epub 2019 May 7.
60 Carbonic anhydrase III (Car3) is not required for fatty acid synthesis and does not protect against high-fat diet induced obesity in mice.PLoS One. 2017 Apr 24;12(4):e0176502. doi: 10.1371/journal.pone.0176502. eCollection 2017.
61 Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice.Cell Mol Immunol. 2019 Nov;16(11):878-886. doi: 10.1038/s41423-018-0032-0. Epub 2018 May 7.
62 ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P.Cell. 2018 Sep 20;175(1):133-145.e15. doi: 10.1016/j.cell.2018.08.020. Epub 2018 Sep 13.
63 Caveolin1 protects against diet induced hepatic lipid accumulation in mice.PLoS One. 2017 Jun 1;12(6):e0178748. doi: 10.1371/journal.pone.0178748. eCollection 2017.
64 Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways.J Clin Invest. 2001 May;107(10):1263-73. doi: 10.1172/JCI11596.
65 Chemokine (C-C motif) ligand 2 gene ablation protects low-density lipoprotein and paraoxonase-1 double deficient mice from liver injury, oxidative stress and inflammation.Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1555-1566. doi: 10.1016/j.bbadis.2019.03.006. Epub 2019 Mar 21.
66 Inflammation and Ectopic Fat Deposition in the Aging Murine Liver Is Influenced by CCR2.Am J Pathol. 2020 Feb;190(2):372-387. doi: 10.1016/j.ajpath.2019.10.016. Epub 2019 Dec 13.
67 CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis.J Hepatol. 2014 Dec;61(6):1365-75. doi: 10.1016/j.jhep.2014.07.006. Epub 2014 Jul 15.
68 Genetic variation in human carboxylesterase CES1 confers resistance to hepatic steatosis.Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Jul;1863(7):688-699. doi: 10.1016/j.bbalip.2018.04.002. Epub 2018 Apr 7.
69 Cadmium exposure exacerbates severe hyperlipidemia and fatty liver changes in zebrafish via impairment of high-density lipoproteins functionality.Toxicol In Vitro. 2018 Mar;47:249-258. doi: 10.1016/j.tiv.2017.11.007. Epub 2017 Nov 29.
70 High-fat diet-induced plasma protein and liver changes in obese rats can be attenuated by melatonin supplementation.Nutr Res. 2017 Jun;42:51-63. doi: 10.1016/j.nutres.2017.04.011. Epub 2017 May 5.
71 Treatment with pirfenidone for two years decreases fibrosis, cytokine levels and enhances CB2 gene expression in patients with chronic hepatitis C.BMC Gastroenterol. 2014 Jul 27;14:131. doi: 10.1186/1471-230X-14-131.
72 Relationship between non-alcoholic steatohepatitis, PNPLA3 I148M genotype and bone mineral density in adolescents.Liver Int. 2018 Dec;38(12):2301-2308. doi: 10.1111/liv.13955. Epub 2018 Sep 25.
73 Chitotriosidase gene expression in Kupffer cells from patients with non-alcoholic fatty liver disease.Gut. 2006 Sep;55(9):1313-20. doi: 10.1136/gut.2005.075697. Epub 2006 Jul 6.
74 The ERLIN1-CHUK-CWF19L1 gene cluster influences liver fat deposition and hepatic inflammation in the NHLBI Family Heart Study.Atherosclerosis. 2013 May;228(1):175-80. doi: 10.1016/j.atherosclerosis.2013.01.038. Epub 2013 Feb 18.
75 PI3K inhibition protects mice from NAFLD by down-regulating CMKLR1 and NLRP3 in Kupffer cells.J Physiol Biochem. 2017 Nov;73(4):583-594. doi: 10.1007/s13105-017-0589-6. Epub 2017 Sep 13.
76 Ciliary neurotrophic factor analogue aggravates CCl(4)-induced acute hepatic injury in rats.Can J Physiol Pharmacol. 2017 May;95(5):620-623. doi: 10.1139/cjpp-2016-0564. Epub 2016 Dec 8.
77 Urea cycle dysregulation in non-alcoholic fatty liver disease.J Hepatol. 2018 Oct;69(4):905-915. doi: 10.1016/j.jhep.2018.06.023. Epub 2018 Jul 5.
78 Cannabidiol attenuates alcohol-induced liver steatosis, metabolic dysregulation, inflammation and neutrophil-mediated injury.Sci Rep. 2017 Sep 21;7(1):12064. doi: 10.1038/s41598-017-10924-8.
79 Liver steatosis in adult patients on home parenteral nutrition.Eur J Clin Nutr. 2020 Feb;74(2):255-260. doi: 10.1038/s41430-019-0455-4. Epub 2019 Jun 24.
80 The transcription cofactor CRTC1 protects from aberrant hepatic lipid accumulation.Sci Rep. 2016 Nov 21;6:37280. doi: 10.1038/srep37280.
81 Molecular mechanisms related to the hepatoprotective effects of antioxidant-rich extra virgin olive oil supplementation in rats subjected to short-term iron administration.Free Radic Biol Med. 2018 Oct;126:313-321. doi: 10.1016/j.freeradbiomed.2018.08.030. Epub 2018 Aug 25.
82 Diagnostic approaches for diabetic cardiomyopathy.Cardiovasc Diabetol. 2017 Feb 23;16(1):28. doi: 10.1186/s12933-017-0506-x.
83 SNX10 mediates alcohol-induced liver injury and steatosis by regulating the activation of chaperone-mediated autophagy.J Hepatol. 2018 Jul;69(1):129-141. doi: 10.1016/j.jhep.2018.01.038. Epub 2018 Feb 13.
84 Inhibiting Extracellular Cathepsin D Reduces Hepatic Steatosis in SpragueDawley Rats (?.Biomolecules. 2019 May 4;9(5):171. doi: 10.3390/biom9050171.
85 Cyp1b1 affects external control of mouse hepatocytes, fatty acid homeostasis and signaling involving HNF4 and PPAR.Arch Biochem Biophys. 2016 May 1;597:30-47. doi: 10.1016/j.abb.2016.03.030. Epub 2016 Mar 29.
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144 Dietary -lactalbumin induced fatty liver by enhancing nuclear liver X receptor /sterol regulatory element-binding protein-1c/PPAR expression and minimising PPAR/carnitine palmitoyltransferase-1 expression and AMP-activated protein kinase phosphorylation associated with atherogenic dyslipidaemia, insulin resistance and oxidative stress in Balb/c mice.Br J Nutr. 2017 Dec;118(11):914-929. doi: 10.1017/S000711451700232X. Epub 2017 Nov 27.
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156 Tumor Progression Locus 2 in Hepatocytes Potentiates Both Liver and Systemic Metabolic Disorders in Mice.Hepatology. 2019 Feb;69(2):524-544. doi: 10.1002/hep.29820. Epub 2018 May 15.
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182 Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy.Sci Rep. 2019 Sep 24;9(1):13789. doi: 10.1038/s41598-019-50219-8.
183 Adipocyte-specific expression of a retinoic acid receptor dominant negative form causes glucose intolerance and hepatic steatosis in mice.Biochem Biophys Res Commun. 2019 Jul 5;514(4):1231-1237. doi: 10.1016/j.bbrc.2019.05.075. Epub 2019 May 17.
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230 Type 2 Diabetes Variants in the SLC16A11 Coding Region Are Not Loss-of-Function Mutations.Cell Rep. 2019 Oct 15;29(3):781-784. doi: 10.1016/j.celrep.2019.09.022.
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259 The Number of Liver Galectin-3 Positive Cells Is Dually Correlated with NAFLD Severity in Children.Int J Mol Sci. 2019 Jul 14;20(14):3460. doi: 10.3390/ijms20143460.
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268 Mice lacking RAP1 show early onset and higher rates of DEN-induced hepatocellular carcinomas in female mice.PLoS One. 2018 Oct 11;13(10):e0204909. doi: 10.1371/journal.pone.0204909. eCollection 2018.
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275 Elafibranor Inhibits Chronic Kidney Disease Progression in NASH Mice.Biomed Res Int. 2019 Jun 19;2019:6740616. doi: 10.1155/2019/6740616. eCollection 2019.
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300 Age modulates liver responses to asparaginase-induced amino acid stress in mice.J Biol Chem. 2019 Sep 20;294(38):13864-13875. doi: 10.1074/jbc.RA119.009864. Epub 2019 Aug 14.
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351 Activation of G0/G1 switch gene 2 by endoplasmic reticulum stress enhances hepatic steatosis.Metabolism. 2019 Oct;99:32-44. doi: 10.1016/j.metabol.2019.06.015. Epub 2019 Jul 2.
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357 Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPAR.Nat Commun. 2019 Apr 11;10(1):1684. doi: 10.1038/s41467-019-09524-z.
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359 Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice.J Hepatol. 2018 Apr;68(4):773-782. doi: 10.1016/j.jhep.2017.11.040. Epub 2017 Dec 20.
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362 ENU mutagenesis identifies mice with cardiac fibrosis and hepatic steatosis caused by a mutation in the mitochondrial trifunctional protein beta-subunit.Hum Mol Genet. 2006 Dec 15;15(24):3569-77. doi: 10.1093/hmg/ddl433. Epub 2006 Nov 20.
363 Differential effects of hyaluronan synthase 3 deficiency after acute vs chronic liver injury in mice.Fibrogenesis Tissue Repair. 2016 Mar 31;9:4. doi: 10.1186/s13069-016-0041-5. eCollection 2016.
364 TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis.Nat Commun. 2016 May 4;7:11379. doi: 10.1038/ncomms11379.
365 Inhibition of hepatocyte nuclear factor 1b induces hepatic steatosis through DPP4/NOX1-mediated regulation of superoxide.Free Radic Biol Med. 2017 Dec;113:71-83. doi: 10.1016/j.freeradbiomed.2017.09.016. Epub 2017 Sep 21.
366 HSPA12A Is a Novel Player in Nonalcoholic Steatohepatitis via Promoting Nuclear PKM2-Mediated M1 Macrophage Polarization.Diabetes. 2019 Feb;68(2):361-376. doi: 10.2337/db18-0035. Epub 2018 Nov 19.
367 Impact of hepatic HSP72 on insulin signaling.Am J Physiol Endocrinol Metab. 2019 Feb 1;316(2):E305-E318. doi: 10.1152/ajpendo.00215.2018. Epub 2018 Dec 11.
368 Protectin DX Ameliorates Hepatic Steatosis by Suppression of Endoplasmic Reticulum Stress via AMPK-Induced ORP150 Expression.J Pharmacol Exp Ther. 2018 Jun;365(3):485-493. doi: 10.1124/jpet.117.246686. Epub 2018 Mar 23.
369 Cytoprotective Mechanisms in Fatty Liver Preservation against Cold Ischemia Injury: A Comparison between IGL-1 and HTK.Int J Mol Sci. 2018 Jan 24;19(2):348. doi: 10.3390/ijms19020348.
370 CXCR6 protects from inflammation and fibrosis in NEMO(LPC-KO) mice.Biochim Biophys Acta Mol Basis Dis. 2019 Feb 1;1865(2):391-402. doi: 10.1016/j.bbadis.2018.11.020. Epub 2018 Nov 24.
371 Inhibition of microRNA-24 expression in liver prevents hepatic lipid accumulation and hyperlipidemia.Hepatology. 2014 Aug;60(2):554-64. doi: 10.1002/hep.27153. Epub 2014 May 19.
372 INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis.World J Gastroenterol. 2018 Jan 14;24(2):195-210. doi: 10.3748/wjg.v24.i2.195.
373 Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain.Mol Metab. 2016 Nov 28;6(1):73-85. doi: 10.1016/j.molmet.2016.11.010. eCollection 2017 Jan.
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376 Hepatic Interferon Regulatory Factor 6 Alleviates Liver Steatosis and Metabolic Disorder by Transcriptionally Suppressing Peroxisome Proliferator-Activated Receptor in Mice.Hepatology. 2019 Jun;69(6):2471-2488. doi: 10.1002/hep.30559. Epub 2019 Apr 22.
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378 JAZF1 ameliorates age and diet-associated hepatic steatosis through SREBP-1c -dependent mechanism.Cell Death Dis. 2018 Aug 28;9(9):859. doi: 10.1038/s41419-018-0923-0.
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380 Histone H3K9 demethylase JMJD2B induces hepatic steatosis through upregulation of PPAR2.Sci Rep. 2018 Sep 13;8(1):13734. doi: 10.1038/s41598-018-31953-x.
381 A Novel Y-Specific Long Non-Coding RNA Associated with Cellular Lipid Accumulation in HepG2 cells and Atherosclerosis-related Genes.Sci Rep. 2017 Dec 1;7(1):16710. doi: 10.1038/s41598-017-17165-9.
382 3-ketodihydrosphingosine reductase mutation induces steatosis and hepatic injury in zebrafish.Sci Rep. 2019 Feb 4;9(1):1138. doi: 10.1038/s41598-018-37946-0.
383 KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance.PLoS One. 2013 Oct 22;8(10):e77851. doi: 10.1371/journal.pone.0077851. eCollection 2013.
384 Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis.J Hepatol. 2013 May;58(5):1000-6. doi: 10.1016/j.jhep.2013.01.020. Epub 2013 Jan 23.
385 Serum cytokeratin-18 and its relation to liver fibrosis and steatosis diagnosed by FibroScan and controlled attenuation parameter in nonalcoholic fatty liver disease and hepatitis C virus patients.Eur J Gastroenterol Hepatol. 2019 May;31(5):633-641. doi: 10.1097/MEG.0000000000001385.
386 Gene expression profiling unravels cancer-related hepatic molecular signatures in steatohepatitis but not in steatosis.PLoS One. 2012;7(10):e46584. doi: 10.1371/journal.pone.0046584. Epub 2012 Oct 10.
387 Ligand-dependent corepressor acts as a novel corepressor of thyroid hormone receptor and represses hepatic lipogenesis in mice.J Hepatol. 2012 Jan;56(1):248-54. doi: 10.1016/j.jhep.2011.07.014. Epub 2011 Aug 7.
388 A dipeptidyl peptidase-IV inhibitor improves hepatic steatosis and insulin resistance by AMPK-dependent and JNK-dependent inhibition of LECT2 expression.Biochem Pharmacol. 2015 Nov 1;98(1):157-66. doi: 10.1016/j.bcp.2015.08.098. Epub 2015 Aug 20.
389 Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.Gastroenterology. 2014 Mar;146(3):801-11. doi: 10.1053/j.gastro.2013.11.008. Epub 2013 Nov 18.
390 Immunopositivity for histone macroH2A1 isoforms marks steatosis-associated hepatocellular carcinoma.PLoS One. 2013;8(1):e54458. doi: 10.1371/journal.pone.0054458. Epub 2013 Jan 23.
391 Loss of CTRP5 improves insulin action and hepatic steatosis.Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E1036-52. doi: 10.1152/ajpendo.00010.2016. Epub 2016 May 3.
392 Hypolipogenic Effect of Shikimic Acid Via Inhibition of MID1IP1 and Phosphorylation of AMPK/ACC.Int J Mol Sci. 2019 Jan 29;20(3):582. doi: 10.3390/ijms20030582.
393 Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease. J Hepatol. 2020 Apr;72(4):627-635.
394 Long non-coding RNA (lncRNA) H19 induces hepatic steatosis through activating MLXIPL and mTORC1 networks in hepatocytes.J Cell Mol Med. 2020 Jan;24(2):1399-1412. doi: 10.1111/jcmm.14818. Epub 2019 Dec 6.
395 Epigenetic programming at the Mogat1 locus may link neonatal overnutrition with long-term hepatic steatosis and insulin resistance.FASEB J. 2018 May 29:fj201700717RR. doi: 10.1096/fj.201700717RR. Online ahead of print.
396 Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in non-alcoholic fatty liver disease.World J Gastroenterol. 2018 Dec 28;24(48):5477-5490. doi: 10.3748/wjg.v24.i48.5477.
397 Fatty acids promote fatty liver disease via the dysregulation of 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway.Gut. 2018 Dec;67(12):2169-2180. doi: 10.1136/gutjnl-2017-313778. Epub 2017 Sep 6.
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404 Highly expressed MT-ND3 positively associated with histological severity of hepatic steatosis.APMIS. 2014 May;122(5):443-51. doi: 10.1111/apm.12166. Epub 2013 Sep 11.
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412 Long-Acting Neurotensin Synergizes With Liraglutide to Reverse Obesity Through a Melanocortin-Dependent Pathway.Diabetes. 2019 Jun;68(6):1329-1340. doi: 10.2337/db18-1009. Epub 2019 Apr 1.
413 Fasting Whole-Body Energy Homeostasis and Hepatic Energy Metabolism in Nondiabetic Humans with Fatty Liver.Oxid Med Cell Longev. 2019 Apr 11;2019:9796175. doi: 10.1155/2019/9796175. eCollection 2019.
414 NogoB receptor in relevant carcinoma: Current achievements, challenges and aims (Review).Int J Oncol. 2018 Nov;53(5):1827-1835. doi: 10.3892/ijo.2018.4520. Epub 2018 Aug 9.
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417 Olfactory receptor 10J5 responding to -cedrene regulates hepatic steatosis via the cAMP-PKA pathway.Sci Rep. 2017 Aug 25;7(1):9471. doi: 10.1038/s41598-017-10379-x.
418 New diagnostic technique to evaluate hepatic steatosis using the attenuation coefficient on ultrasound B mode.PLoS One. 2019 Aug 27;14(8):e0221548. doi: 10.1371/journal.pone.0221548. eCollection 2019.
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