Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZHB37)

• Drug Name: GSK2110183 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
leukaemia	2A60-2B33	Phase 2	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 2	[2]
Multiple myeloma	2A83	Phase 1	[3]

• Cross-matching ID:
  PubChem CID: 46843057
  ChEBI ID: CHEBI:131168
  CAS Number: CAS 1047644-62-1
  TTD Drug ID: DMZHB37

Molecule-Related Drug Atlas

Drug(s) Targeting RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[6]
Enzastaurin	DM5H0R9	Diffuse large B-cell lymphoma	2A81	Phase 3	[6]
GDC-0068	DMWBZJD	Breast cancer	2C60-2C65	Phase 3	[6]
CI-1033	DMSI8N3	Lymphoma	2A80-2A86	Phase 2	[7]
CMX-2043	DMPSCVY	Cardiac disease	BA00-BE2Z	Phase 2	[8]
ARQ 092	DM5WK0J	Proteus syndrome	LD2C	Phase 2	[9]
RX-0201	DMTBAV3	Pancreatic cancer	2C10	Phase 2	[10]
PTX-200	DM0ZIT2	Breast cancer	2C60-2C65	Phase 2	[6]
Triciribine prodrug	DMBN1XS	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[4]
M2698	DM3PVBJ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[11]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[12]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[13]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[14]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[17]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[19]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[20]

Drug(s) Affected By LYR motif-containing protein 9 (LYRM9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[27]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[28]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[29]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Small integral membrane protein 1 (SMIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[35]

Drug(s) Affected By Aldo-keto reductase family 1 member B15 (AKR1B15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
2,3-dihydroxypropanal	DMOWNB4	Discovery agent	N.A.	Investigative	[41]

Drug(s) Affected By Activator of apoptosis harakiri (HRK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[42]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[42]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[48]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]

Drug(s) Affected By Cell division cycle 7-related protein kinase (CDC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[57]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[58]

Drug(s) Affected By Serine/threonine-protein kinase PLK4 (PLK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[62]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[63]

Drug(s) Affected By Tripeptidyl-peptidase 1 (TPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[70]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[71]

Drug(s) Affected By 5-oxoprolinase (OPLAH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[55]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[73]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[74]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[75]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[80]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By DNA-directed RNA polymerase III subunit RPC7 (POLR3G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]

Drug(s) Affected By Monocarboxylate transporter 6 (SLC16A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[82]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[83]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[84]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[86]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[87]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[89]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[91]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[92]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[93]

Drug(s) Affected By Ras GTPase-activating protein 4 (RASA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[95]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[97]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[100]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[101]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[102]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]

Drug(s) Affected By Maleylacetoacetate isomerase (GSTZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[104]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[105]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[49]

Drug(s) Affected By Keratin, type II cuticular Hb6 (KRT86)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[113]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[114]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[115]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Mitochondrial import inner membrane translocase subunit Tim8 A (TIMM8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]

Drug(s) Affected By Nuclear protein 1 (NUPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[118]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[119]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[120]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[118]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[119]

Drug(s) Affected By HMG box-containing protein 1 (HBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]

Drug(s) Affected By DNA polymerase theta (POLQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[58]

Drug(s) Affected By Cell division control protein 45 homolog (CDC45)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[125]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[127]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]

Drug(s) Affected By Carbonic anhydrase-related protein 11 (CA11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[129]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[130]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[131]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Calpain-15 (CAPN15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Bortezomib	DMNO38U	Leukemia		Approved	[132]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[134]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[135]

Drug(s) Affected By Trafficking protein particle complex subunit 6A (TRAPPC6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[129]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[137]

Drug(s) Affected By Short-chain dehydrogenase/reductase 3 (DHRS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[138]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[139]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]

Drug(s) Affected By Annexin A9 (ANXA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[141]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[143]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[43]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[137]

Drug(s) Affected By Delta(14)-sterol reductase TM7SF2 (TM7SF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[144]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[90]

Drug(s) Affected By cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Tadalafil	DMJZHT1	Benign prostatic hyperplasia	GA90	Approved	[146]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Vardenafil	DMTBGW8	Cystic fibrosis	CA25	Approved	[146]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[147]

Drug(s) Affected By Fibrinogen silencer-binding protein (RAD54B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[57]

Drug(s) Affected By Mitochondrial proton/calcium exchanger protein (LETM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[149]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[73]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[151]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[152]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[154]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[157]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]

Drug(s) Affected By V-type proton ATPase subunit G 2 (ATP6V1G2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[159]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[160]

Drug(s) Affected By Heat shock 70 kDa protein 4L (HSPA4L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[42]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[161]

Drug(s) Affected By Chloride intracellular channel protein 3 (CLIC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[162]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[130]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]

Drug(s) Affected By Acyl-CoA 6-desaturase (FADS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[152]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[164]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[165]
Bortezomib	DMNO38U	Leukemia		Approved	[132]

Drug(s) Affected By Polyglutamylase complex subunit TTLL1 (TTLL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[131]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[166]

Drug(s) Affected By Sphingosine 1-phosphate receptor 4 (S1PR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[168]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]

Drug(s) Affected By Mitochondrial import receptor subunit TOM40 homolog (TOMM40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[171]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[172]

Drug(s) Affected By G1/S-specific cyclin-E2 (CCNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[174]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[176]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[177]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[178]

Drug(s) Affected By Dihydrofolate reductase (DHFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[179]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[182]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[183]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[181]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]

Drug(s) Affected By Complement C1r subcomponent (C1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[184]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[185]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[186]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[187]
Fructose	DM43AN2	Vomiting	MD90	Approved	[188]
Ketoprofen	DMRKXPT	Bursitis		Approved	[188]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[189]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[190]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[191]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[192]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[194]

Drug(s) Affected By Angiogenin (ANG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[57]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[195]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[71]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[196]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[197]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[198]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[199]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[188]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[152]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[201]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[202]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[203]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[204]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[207]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[208]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[209]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]

Drug(s) Affected By Fibroblast growth factor 1 (FGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[210]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[210]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[212]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[210]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]

Drug(s) Affected By Neuroendocrine protein 7B2 (SCG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[213]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[214]

Drug(s) Affected By Insulin receptor (INSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[215]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[216]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[217]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[218]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[219]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[58]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[220]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Selenium	DM25CGV	N. A.	N. A.	Approved	[221]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[222]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[223]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[224]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]

Drug(s) Affected By Eukaryotic translation initiation factor 4E (EIF4E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[228]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[229]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[230]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[229]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]

Drug(s) Affected By Pro-cathepsin H (CTSH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[232]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[233]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[107]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[184]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[234]

Drug(s) Affected By Complement C1s subcomponent (C1S)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[235]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 2 (IFIT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[236]

Drug(s) Affected By Fructose-bisphosphate aldolase C (ALDOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[237]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[152]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[238]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[228]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]

Drug(s) Affected By Histone H2A type 1 (H2AC11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[177]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[21]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]

Drug(s) Affected By Mast/stem cell growth factor receptor Kit (KIT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[239]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[242]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[243]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[244]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[245]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Selenium	DM25CGV	N. A.	N. A.	Approved	[221]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[247]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[224]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[248]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]

Drug(s) Affected By Ornithine decarboxylase (ODC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[251]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[252]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[210]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[210]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[253]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[167]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[254]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[255]

Drug(s) Affected By Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[141]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[235]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By Farnesyl pyrophosphate synthase (FDPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[256]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[258]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]

Drug(s) Affected By Junction plakoglobin (JUP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[259]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[235]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[260]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]

Drug(s) Affected By Integrin beta-4 (ITGB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[104]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[261]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[224]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[262]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[261]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[253]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[235]

Drug(s) Affected By Histone H1.5 (H1-5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[263]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[177]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[21]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]

Drug(s) Affected By Histone H1.3 (H1-3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[177]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[265]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[267]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[268]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[59]

Drug(s) Affected By Carboxypeptidase E (CPE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[269]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[270]

Drug(s) Affected By CTP synthase 1 (CTPS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[242]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[58]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[90]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[271]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[259]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[58]

Drug(s) Affected By Insulin-like growth factor-binding protein 3 (IGFBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[272]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[273]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[274]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[210]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[138]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[275]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[276]

Drug(s) Affected By Tetraspanin-8 (TSPAN8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[277]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[159]
ACYLINE	DM9GRTK	Prostate cancer	2C82.0	Phase 2	[278]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[279]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[220]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[89]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[280]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[281]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[124]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]

Drug(s) Affected By Tenascin-X (TNXB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[90]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[283]

Drug(s) Affected By Fibulin-1 (FBLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[75]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[285]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[286]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[287]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[288]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[289]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[290]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[291]

Drug(s) Affected By Deoxyribonuclease-1 (DNASE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[210]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[210]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[292]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[49]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[293]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[293]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[220]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[294]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[295]
Selenium	DM25CGV	N. A.	N. A.	Approved	[221]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[296]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[297]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[298]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[248]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[104]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[299]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[300]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[301]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[302]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[303]
Fructose	DM43AN2	Vomiting	MD90	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[305]

Drug(s) Affected By Pentraxin-related protein PTX3 (PTX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[306]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[307]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[184]
Bortezomib	DMNO38U	Leukemia		Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]

Drug(s) Affected By Hepatocyte growth factor-like protein (MST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[308]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[309]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[310]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[309]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[149]

Drug(s) Affected By Progranulin (GRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[90]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]

Drug(s) Affected By Caspase-1 (CASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[311]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[312]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[313]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[314]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[315]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[316]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[232]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[233]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[318]

Drug(s) Affected By M-phase inducer phosphatase 1 (CDC25A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[174]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[319]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[249]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[320]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[321]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[322]

Drug(s) Affected By Neuronal acetylcholine receptor subunit alpha-5 (CHRNA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[323]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[55]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[324]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[310]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[325]

Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 (RRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[326]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[182]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]

Drug(s) Affected By Guanylate-binding protein 2 (GBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]

Drug(s) Affected By DNA replication licensing factor MCM4 (MCM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[125]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[327]

Drug(s) Affected By Hydroxymethylglutaryl-CoA lyase, mitochondrial (HMGCL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[172]

Drug(s) Affected By Squalene synthase (FDFT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[256]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[152]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[328]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[176]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[329]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[330]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[331]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[222]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[332]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[296]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[174]

Drug(s) Affected By Flap endonuclease 1 (FEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[333]

Drug(s) Affected By Replication factor C subunit 3 (RFC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[334]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]

Drug(s) Affected By Reduced folate transporter (SLC19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[335]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[336]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[336]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[337]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[337]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[337]

Drug(s) Affected By 5-hydroxytryptamine receptor 2B (HTR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[188]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[339]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Bortezomib	DMNO38U	Leukemia		Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[340]
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[341]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Lamina-associated polypeptide 2, isoform alpha (TMPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[231]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[342]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[343]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[344]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[344]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[342]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[342]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[345]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[346]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[347]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[348]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[286]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[287]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[349]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[20]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[350]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[351]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[352]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[353]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[354]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[355]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[356]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[357]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[358]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[359]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[360]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[361]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[362]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[363]

Drug(s) Affected By Methylenetetrahydrofolate reductase (MTHFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[364]
Benazepril	DMH1M9B	Hypertension	BA00-BA04	Approved	[365]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[366]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[367]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]

Drug(s) Affected By Cathepsin O (CTSO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[368]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[55]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[310]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[369]
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[95]

Drug(s) Affected By Cathepsin K (CTSK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[370]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[371]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[235]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[372]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]

Drug(s) Affected By Aldehyde dehydrogenase family 3 member B1 (ALDH3B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[104]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[82]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[130]

Drug(s) Affected By Cytosolic phospholipase A2 (PLA2G4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[373]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[374]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[375]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[376]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[377]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]

Drug(s) Affected By Lanosterol synthase (LSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[118]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[378]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[118]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[118]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[119]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[118]

Drug(s) Affected By Thrombospondin-3 (THBS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[139]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[372]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[379]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[129]

Drug(s) Affected By Regulator of G-protein signaling 4 (RGS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[75]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[75]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[75]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[380]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[381]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[382]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[383]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[384]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[125]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[385]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[386]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1C (CDKN1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[210]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[210]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[132]

Drug(s) Affected By Sulfotransferase 1A2 (SULT1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[387]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[388]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[389]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (PLCD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[390]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[131]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[166]

Drug(s) Affected By Signal transducer and activator of transcription 2 (STAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[391]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[392]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[393]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]

Drug(s) Affected By ATP-citrate synthase (ACLY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[394]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[302]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[395]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[396]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[339]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[397]

Drug(s) Affected By Diphosphomevalonate decarboxylase (MVD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[398]

Drug(s) Affected By RecQ-like DNA helicase BLM (BLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[399]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[400]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[401]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[402]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[403]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[403]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[224]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[404]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[405]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[406]

Drug(s) Affected By DNA polymerase epsilon subunit 2 (POLE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]

Drug(s) Affected By 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[407]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[152]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]

Drug(s) Affected By Histone H4 (H4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[136]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[408]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[388]

Drug(s) Affected By Histone H3.1 (H3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[177]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]

Drug(s) Affected By Metallothionein-1X (MT1X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[409]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[410]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[388]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]

Drug(s) Affected By Transcription factor A, mitochondrial (TFAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[411]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[412]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[413]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[414]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[415]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[416]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[417]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[418]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[294]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[419]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[174]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[281]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[237]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[420]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[420]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[421]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[420]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]

Drug(s) Affected By Kinesin-like protein KIF23 (KIF23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[422]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[423]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]

Drug(s) Affected By Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase , mitochondrial (ALDH6A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[424]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[42]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[425]

Drug(s) Affected By Lamin-B2 (LMNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[426]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[427]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[172]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[428]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[429]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[430]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[342]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[343]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[431]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[342]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[342]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[124]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[432]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[431]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[342]

Drug(s) Affected By Islet cell autoantigen 1 (ICA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[90]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]

Drug(s) Affected By GA-binding protein subunit beta-1 (GABPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[433]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[71]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[433]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[434]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]

Drug(s) Affected By DNA repair protein RAD51 homolog 1 (RAD51)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[435]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[436]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[437]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[438]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[439]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[363]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[440]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[104]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[441]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[331]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[442]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[296]

Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[443]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[445]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[446]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[447]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[448]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]

Drug(s) Affected By Prolow-density lipoprotein receptor-related protein 1 (LRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[388]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[449]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[450]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]

Drug(s) Affected By Dematin (DMTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[131]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[35]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[451]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase D (PPID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[389]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[452]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[310]

Drug(s) Affected By D site-binding protein (DBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[453]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[454]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[166]

Drug(s) Affected By Forkhead box protein O1 (FOXO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[455]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[456]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[235]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By Proline-rich nuclear receptor coactivator 1 (PNRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[305]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[234]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[270]

Drug(s) Affected By Cell division cycle protein 20 homolog (CDC20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[457]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]

Drug(s) Affected By Filensin (BFSP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[310]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[458]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]

Drug(s) Affected By Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[459]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]

Drug(s) Affected By Chromatin assembly factor 1 subunit B (CHAF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[174]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[174]

Drug(s) Affected By Pappalysin-1 (PAPPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[388]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[334]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[372]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[460]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[461]

Drug(s) Affected By Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[316]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]

Drug(s) Affected By S-phase kinase-associated protein 2 (SKP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[462]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[463]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]

Drug(s) Affected By Origin recognition complex subunit 1 (ORC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[464]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[327]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[465]

Drug(s) Affected By Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[421]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[152]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[305]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]

Drug(s) Affected By DNA polymerase alpha subunit B (POLA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[182]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[333]

Drug(s) Affected By DNA replication licensing factor MCM6 (MCM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[125]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[459]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[182]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]

Drug(s) Affected By Max dimerization protein 4 (MXD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[333]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[259]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[310]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[259]

Drug(s) Affected By Maternal embryonic leucine zipper kinase (MELK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[333]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]

Drug(s) Affected By DNA replication complex GINS protein PSF1 (GINS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]

Drug(s) Affected By Phosphatidate phosphatase LPIN1 (LPIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[152]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[466]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[132]

Drug(s) Affected By Golgin subfamily B member 1 (GOLGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[237]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[467]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[468]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]

Drug(s) Affected By Transmembrane glycoprotein NMB (GPNMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[178]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]

Drug(s) Affected By Nucleolar and coiled-body phosphoprotein 1 (NOLC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[90]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[63]

Drug(s) Affected By Cullin-7 (CUL7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[35]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[469]

Drug(s) Affected By kinase isozyme 2, mitochondrial (PDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[316]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Bortezomib	DMNO38U	Leukemia		Approved	[132]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[470]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[135]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Ribosomal protein S6 kinase alpha-2 (RPS6KA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[269]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[471]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[265]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[71]

Drug(s) Affected By Transcription elongation factor A protein 2 (TCEA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[71]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]

Drug(s) Affected By Pachytene checkpoint protein 2 homolog (TRIP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[424]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[327]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[242]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]

Drug(s) Affected By Methylsterol monooxygenase 1 (MSMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[152]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[232]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[232]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]

Drug(s) Affected By Pregnancy-specific beta-1-glycoprotein 3 (PSG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Cardiotrophin-1 (CTF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[472]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Serine/arginine-rich splicing factor 7 (SRSF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[263]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[473]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[237]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[467]

Drug(s) Affected By Prostasin (PRSS8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[474]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[259]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[475]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[476]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[477]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[478]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[479]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[480]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[481]

Drug(s) Affected By Histone H2A type 2-C (H2AC20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[237]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[482]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[483]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[177]
Haloperidol	DM96SE0	Delirium		Approved	[237]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[237]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[237]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[136]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[459]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[237]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[484]

Drug(s) Affected By Dual specificity protein phosphatase 6 (DUSP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[485]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[486]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]

Drug(s) Affected By Inverted formin-2 (INF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[43]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[135]

Drug(s) Affected By DNA excision repair protein ERCC-6-like (ERCC6L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[327]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[487]

Drug(s) Affected By Leucine-rich repeat-containing protein 75B (LRRC75B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[310]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[454]

Drug(s) Affected By Atos homolog protein A (ATOSA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[178]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[178]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[178]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[178]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[178]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[468]

Drug(s) Affected By Protein MIX23 (MIX23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[29]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[488]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[487]

Drug(s) Affected By Programmed cell death protein 4 (PDCD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[489]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[490]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[489]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[491]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[489]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]

Drug(s) Affected By Centrosomal protein of 55 kDa (CEP55)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[333]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[492]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[57]

Drug(s) Affected By Borealin (CDCA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[327]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[333]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[465]

Drug(s) Affected By N-acetyltransferase ESCO2 (ESCO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[334]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[132]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[57]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]

Drug(s) Affected By Caspase recruitment domain-containing protein 16 (CARD16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[311]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[130]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[493]

Drug(s) Affected By Shugoshin 1 (SGO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[334]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[487]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[268]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[494]

Drug(s) Affected By IQ motif and SEC7 domain-containing protein 2 (IQSEC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Testis-expressed protein 30 (TEX30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[233]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[495]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]

Drug(s) Affected By Transmembrane protein 201 (TMEM201)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[496]

Drug(s) Affected By All trans-polyprenyl-diphosphate synthase PDSS1 (PDSS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[497]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[242]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]

Drug(s) Affected By Transmembrane protein 170B (TMEM170B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[372]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[57]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]

Drug(s) Affected By BEN domain-containing protein 3 (BEND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[310]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[129]

Drug(s) Affected By ATPase family AAA domain-containing protein 3B (ATAD3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[237]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[428]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[166]

Drug(s) Affected By SH3 and PX domain-containing protein 2A (SH3PXD2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[235]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[90]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]

Drug(s) Affected By Ankyrin repeat domain-containing protein 22 (ANKRD22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[498]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[244]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[131]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Carboxylesterase 4A (CES4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[115]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[454]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]

Drug(s) Affected By Cell division cycle-associated protein 2 (CDCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[42]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[177]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[327]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]

Drug(s) Affected By Protein Jade-1 (JADE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[372]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[499]

Drug(s) Affected By LLGL scribble cell polarity complex component 2 (LLGL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[500]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[501]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]

Drug(s) Affected By LETM1 domain-containing protein 1 (LETMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[502]

Drug(s) Affected By Mitochondrial fission regulator 2 (MTFR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[57]

Drug(s) Affected By Long-chain fatty acid transport protein 1 (SLC27A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[503]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[132]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[184]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[504]

Drug(s) Affected By Kelch-like protein 35 (KLHL35)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[310]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[130]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[310]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]

Drug(s) Affected By ATPase family AAA domain-containing protein 2 (ATAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[505]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[178]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[178]

Drug(s) Affected By Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (PAOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[389]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[454]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[74]

Drug(s) Affected By Serine protease FAM111B (FAM111B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[465]

Drug(s) Affected By Kelch-like protein 24 (KLHL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[305]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[80]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[305]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]

Drug(s) Affected By CREB-regulated transcription coactivator 1 (CRTC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[506]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[35]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Cerebellin-3 (CBLN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[389]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[507]

Drug(s) Affected By Proprotein convertase subtilisin/kexin type 4 (PCSK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[508]

Drug(s) Affected By Protein MMS22-like (MMS22L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[495]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[494]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[509]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[166]
crotylaldehyde	DMTWRQI	Discovery agent	N.A.	Investigative	[510]

Drug(s) Affected By Rho GTPase-activating protein 27 (ARHGAP27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[135]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[160]

Drug(s) Affected By Patatin-like phospholipase domain-containing protein 7 (PNPLA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[454]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[149]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAMTS13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[429]

Drug(s) Affected By Tubulin epsilon and delta complex protein 2 (TEDC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[454]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]

Drug(s) Affected By Protein MCM10 homolog (MCM10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[327]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[333]

Drug(s) Affected By #NAME?

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[511]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]

Drug(s) Affected By Tripartite motif-containing protein 46 (TRIM46)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[131]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
uric acid	DMA1MKT	Discovery agent	N.A.	Investigative	[512]

Drug(s) Affected By Protein TAMALIN (TAMALIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[393]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[130]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[135]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]

Drug(s) Affected By Phosphatidylinositol-glycan biosynthesis class W protein (PIGW)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[270]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[71]

Drug(s) Affected By Transmembrane protein 150A (TMEM150A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[487]

Drug(s) Affected By GPI mannosyltransferase 4 (PIGZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[506]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[494]

Drug(s) Affected By Phosphofurin acidic cluster sorting protein 2 (PACS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[334]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[35]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Stimulator of interferon genes protein (STING1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[130]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[135]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]

Drug(s) Affected By Dynein axonemal assembly factor 11 (DNAAF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[494]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[513]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 3B (PPP1R3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[55]

Drug(s) Affected By CREB3 regulatory factor (CREBRF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[514]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[515]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]

Drug(s) Affected By DNA damage-induced apoptosis suppressor protein (DDIAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[460]

Drug(s) Affected By Lamin tail domain-containing protein 2 (LMNTD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[130]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Leucine-rich repeat-containing protein 56 (LRRC56)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]

Drug(s) Affected By Centromere protein L (CENPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[182]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[334]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[168]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[268]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[494]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Dynein assembly factor with WD repeat domains 1 (DAW1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[130]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[516]

Drug(s) Affected By RIB43A-like with coiled-coils protein 1 (RIBC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[43]

Drug(s) Affected By Ubiquitin carboxyl-terminal hydrolase MINDY-1 (MINDY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[90]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Junction-mediating and -regulatory protein (JMY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[55]

Drug(s) Affected By Exonuclease mut-7 homolog (EXD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[82]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[131]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[517]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[47]

Drug(s) Affected By Potassium voltage-gated channel subfamily H member 5 (KCNH5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[498]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[214]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[47]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[74]

Drug(s) Affected By Cation channel sperm-associated protein 1 (CATSPER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By SHC SH2 domain-binding protein 1 (SHCBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[334]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[57]

Drug(s) Affected By MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (MDGA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[518]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]

Drug(s) Affected By Bestrophin-4 (BEST4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[43]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[47]

Drug(s) Affected By F-box only protein 27 (FBXO27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]

Drug(s) Affected By Polyribonucleotide nucleotidyltransferase 1, mitochondrial (PNPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[90]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[500]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[519]

Drug(s) Affected By Ribosome biogenesis protein BRX1 homolog (BRIX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[520]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[475]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[29]

Drug(s) Affected By Sorting nexin-29 (SNX29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[495]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[509]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[35]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[521]

Drug(s) Affected By Apoptosis-enhancing nuclease (AEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[177]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[522]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]

Drug(s) Affected By Nucleolar complex protein 3 homolog (NOC3L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[159]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]

Drug(s) Affected By Neuferricin (CYB5D2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[422]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[129]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]

Drug(s) Affected By Glutathione-specific gamma-glutamylcyclotransferase 2 (CHAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[523]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]

Drug(s) Affected By Protein prune homolog 2 (PRUNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[524]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[372]

Drug(s) Affected By Hexosaminidase D (HEXD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Bortezomib	DMNO38U	Leukemia		Approved	[132]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[134]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[29]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Na(+)/dicarboxylate cotransporter 3 (SLC13A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[525]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[498]
Succinic acid	DMDWICP	Malnutrition	5B50-5B71	Approved	[526]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[71]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[527]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[129]

Drug(s) Affected By Lipase member H (LIPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[334]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[528]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[528]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[528]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[529]

Drug(s) Affected By Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[499]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[472]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
EMODIN	DMAEDQG	Coronavirus Disease 2019 (COVID-19)	1D6Y	Terminated	[530]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[47]
cycloheximide	DMGDA3C	Discovery agent	N.A.	Investigative	[531]

Drug(s) Affected By Cyclic GMP-AMP phosphodiesterase SMPDL3A (SMPDL3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[90]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[506]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[500]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[532]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[40]

Drug(s) Affected By (3R)-3-hydroxyacyl-CoA dehydrogenase (HSD17B8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[242]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[339]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]

Drug(s) Affected By DNA repair and recombination protein RAD54-like (RAD54L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[465]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[533]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 14 (TNFRSF14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[534]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[464]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[535]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[48]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[292]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]

Drug(s) Affected By Homeobox protein DLX-4 (DLX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[104]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[536]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[388]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[537]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[270]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]

Drug(s) Affected By Betaine--homocysteine S-methyltransferase 1 (BHMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[538]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[539]
Betaine	DMGRZW2	Cystitis	GC00	Approved	[540]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]

Drug(s) Affected By Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[242]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[71]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[372]

Drug(s) Affected By F-box only protein 32 (FBXO32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[409]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[305]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[409]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[305]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[334]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[49]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 19L (RELT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[135]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Patatin-like phospholipase domain-containing protein 2 (PNPLA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[396]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[372]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[82]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
Beta-caryophyllene	DM7583A	Pain	MG30-MG3Z	Phase 2	[541]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[494]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[73]
D-glucose	DMMG2TO	Discovery agent	N.A.	Investigative	[542]

Drug(s) Affected By RAD51-associated protein 1 (RAD51AP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[104]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[334]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[333]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[57]

Drug(s) Affected By Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[372]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]

Drug(s) Affected By U5 small nuclear ribonucleoprotein 40 kDa protein (SNRNP40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[63]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[496]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[35]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[543]

Drug(s) Affected By Receptor-transporting protein 4 (RTP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[391]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[131]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[544]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[545]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[122]

Drug(s) Affected By CAP-Gly domain-containing linker protein 3 (CLIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[348]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[129]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]

Drug(s) Affected By Sperm acrosome-associated protein 9 (SPACA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[149]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[166]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[122]

Drug(s) Affected By Protein Hook homolog 2 (HOOK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[546]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[547]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Corrinoid adenosyltransferase MMAB (MMAB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[467]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[82]

Drug(s) Affected By BLOC-1-related complex subunit 8 (BORCS8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[310]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[43]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[35]

Drug(s) Affected By Chronophin (PDXP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[548]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[529]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[454]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[149]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]

Drug(s) Affected By BLOC-1-related complex subunit 6 (BORCS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[35]

Drug(s) Affected By SH3 domain-containing YSC84-like protein 1 (SH3YL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[90]

Drug(s) Affected By Selenocysteine lyase (SCLY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[122]

Drug(s) Affected By Lymphokine-activated killer T-cell-originated protein kinase (PBK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[549]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]

Drug(s) Affected By Protein FAM167A (FAM167A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[178]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[178]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[454]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]

Drug(s) Affected By Bcl-2-modifying factor (BMF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[528]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[550]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[551]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[36]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[292]

Drug(s) Affected By Cilia- and flagella-associated protein 57 (CFAP57)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[299]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[136]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[552]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[553]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[124]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[554]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[555]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[102]

Drug(s) Affected By Guanylate-binding protein 5 (GBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[168]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[214]
Nabiximols	DMHKJ5I	Cancer related pain	MG30	Phase 3	[556]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Guanylate-binding protein 4 (GBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[499]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[40]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[494]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Kinesin-like protein KIF20B (KIF20B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[316]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[136]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[557]

Drug(s) Affected By Small integral membrane protein 14 (SMIM14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[528]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[528]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[65]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[528]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]

Drug(s) Affected By Cbp/p300-interacting transactivator 4 (CITED4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[495]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[82]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[130]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]

Drug(s) Affected By Intraflagellar transport protein 140 homolog (IFT140)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[128]

Drug(s) Affected By Hyaluronan and proteoglycan link protein 3 (HAPLN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[523]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[518]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[135]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[166]

Drug(s) Affected By Ethanolamine-phosphate cytidylyltransferase (PCYT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[372]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[470]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]

Drug(s) Affected By Sialidase-1 (NEU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[136]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[152]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[528]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[558]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]

Drug(s) Affected By Ribonucleases P/MRP protein subunit POP1 (POP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By TSC22 domain family protein 3 (TSC22D3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[559]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[409]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[560]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[132]

Drug(s) Affected By Protein SCAF11 (SCAF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[515]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[80]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[561]

Drug(s) Affected By Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[562]

Drug(s) Affected By BRCA1-associated RING domain protein 1 (BARD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[333]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[57]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[563]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[564]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[62]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[565]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]

Drug(s) Affected By Equilibrative nucleoside transporter 1 (SLC29A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[566]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[567]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[568]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[525]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[569]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]

Drug(s) Affected By Condensin complex subunit 3 (NCAPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[333]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]

Drug(s) Affected By DNA replication complex GINS protein SLD5 (GINS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Peroxiredoxin-like 2A (PRXL2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[372]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]

Drug(s) Affected By Centromere protein K (CENPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[57]

Drug(s) Affected By Phosphatidylinositol 4-kinase type 2-alpha (PI4K2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[570]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[570]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Centromere protein O (CENPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[571]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[454]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]

Drug(s) Affected By Spondin-2 (SPON2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[127]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[235]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[532]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[130]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[159]

Drug(s) Affected By Sister chromatid cohesion protein DCC1 (DSCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]

Drug(s) Affected By Mitochondrial import inner membrane translocase subunit Tim21 (TIMM21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[389]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[29]

Drug(s) Affected By TIMELESS-interacting protein (TIPIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[174]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[174]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[174]

Drug(s) Affected By Acetyl-CoA acetyltransferase, cytosolic (ACAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[242]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[258]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[572]

Drug(s) Affected By Cell division cycle-associated protein 7 (CDCA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[573]

Drug(s) Affected By Cyclin-dependent kinase 19 (CDK19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[42]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[136]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[515]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[42]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]

Drug(s) Affected By Bardet-Biedl syndrome 2 protein (BBS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[90]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]

Drug(s) Affected By Serine/threonine-protein kinase PINK1, mitochondrial (PINK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[574]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[575]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[575]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[576]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[577]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[578]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[579]

Drug(s) Affected By Voltage-dependent calcium channel gamma-6 subunit (CACNG6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[71]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[130]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[580]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[131]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Equilibrative nucleoside transporter 3 (SLC29A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[525]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[581]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[581]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM4 (TRIM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[270]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[460]

Drug(s) Affected By Protein FAM117A (FAM117A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[528]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[528]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[528]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]

Drug(s) Affected By Tetraspanin-10 (TSPAN10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[460]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
AM251	DMTAWHL	Discovery agent	N.A.	Investigative	[582]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAMTS10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[583]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[516]

Drug(s) Affected By Protein FAM83D (FAM83D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[177]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[333]

Drug(s) Affected By RIB43A-like with coiled-coils protein 2 (RIBC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[90]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[494]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[584]

Drug(s) Affected By Occludin/ELL domain-containing protein 1 (OCEL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[71]

Drug(s) Affected By Proline-rich protein 36 (PRR36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[310]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[129]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[130]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[35]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[585]

Drug(s) Affected By Aurora kinase A- and ninein-interacting protein (AUNIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[334]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[454]

Drug(s) Affected By Nucleolar protein 11 (NOL11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[166]

Drug(s) Affected By Claspin (CLSPN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]

Drug(s) Affected By Kinetochore protein Spc25 (SPC25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[327]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By DNA polymerase delta subunit 4 (POLD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[422]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[464]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[388]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]

Drug(s) Affected By Transmembrane protein 138 (TMEM138)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[310]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[55]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]

Drug(s) Affected By Anillin (ANLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[327]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[333]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]

Drug(s) Affected By Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium Acetate Anhydrous	DMH21E0	Hyponatraemia	5C72	Approved	[586]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[152]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[36]

Drug(s) Affected By Nucleolar RNA helicase 2 (DDX21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[473]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[242]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[231]

Drug(s) Affected By Translation initiation factor eIF2B subunit gamma (EIF2B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[467]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[82]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[496]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[509]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]

Drug(s) Affected By COX assembly mitochondrial protein 2 homolog (CMC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[310]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[587]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[468]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[166]

Drug(s) Affected By Phospholipid scramblase 4 (PLSCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[104]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[588]

Drug(s) Affected By RNA-binding protein PNO1 (PNO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Bortezomib	DMNO38U	Leukemia		Approved	[132]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[234]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]

Drug(s) Affected By Lymphoid-specific helicase (HELLS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]

Drug(s) Affected By E3 ubiquitin-protein ligase RAD18 (RAD18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[589]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[310]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[496]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[509]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]

Drug(s) Affected By Phenylalanine--tRNA ligase beta subunit (FARSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[237]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[467]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[270]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[90]

Drug(s) Affected By FIGNL1-interacting regulator of recombination and mitosis (FIRRM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[129]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[369]

Drug(s) Affected By Protein diaphanous homolog 3 (DIAPH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]

Drug(s) Affected By Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 (PCMTD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[310]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[166]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[96]

Drug(s) Affected By ATPase family AAA domain-containing protein 3A (ATAD3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[473]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[237]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[467]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[590]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]

Drug(s) Affected By Histone chaperone ASF1B (ASF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[327]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[333]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[465]

Drug(s) Affected By HAUS augmin-like complex subunit 2 (HAUS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[82]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[591]

Drug(s) Affected By PCNA-interacting partner (PARPBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]

Drug(s) Affected By Cell growth-regulating nucleolar protein (LYAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[161]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[90]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]

Drug(s) Affected By Pyroglutamyl-peptidase 1 (PGPEP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[548]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[134]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[494]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[454]

Drug(s) Affected By Protein downstream neighbor of Son (DONSON)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[333]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[487]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[159]

Drug(s) Affected By Denticleless protein homolog (DTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[592]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]

Drug(s) Affected By Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[593]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[369]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[594]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By BRCA2 and CDKN1A-interacting protein (BCCIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[595]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[63]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[310]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[496]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[596]

Drug(s) Affected By Homologous-pairing protein 2 homolog (PSMC3IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[536]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[174]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]

Drug(s) Affected By Cathepsin F (CTSF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[597]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[166]

Drug(s) Affected By Mitochondrial dicarboxylate carrier (SLC25A10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[525]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[116]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]

Drug(s) Affected By RIMS-binding protein 3A (RIMBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[35]

Drug(s) Affected By Testin (TES)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[237]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]

Drug(s) Affected By E3 ISG15--protein ligase HERC5 (HERC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[75]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[75]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[75]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[71]

Drug(s) Affected By F-box only protein 2 (FBXO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[235]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]

Drug(s) Affected By mRNA turnover protein 4 homolog (MRTO4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[391]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[475]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[598]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]

Drug(s) Affected By Ergosterol biosynthetic protein 28 homolog (ERG28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[152]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[486]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[389]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]

Drug(s) Affected By F-box only protein 5 (FBXO5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[177]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 5 (ACSL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[599]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[372]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]

Drug(s) Affected By Zinc transporter ZIP10 (SLC39A10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[525]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[600]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]

Drug(s) Affected By Protein NDRG4 (NDRG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[388]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[55]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]

Drug(s) Affected By Ras-related protein Rab-26 (RAB26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[178]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[178]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]

Drug(s) Affected By Inhibitor of growth protein 4 (ING4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[311]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[269]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[601]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[602]

Drug(s) Affected By Exonuclease 1 (EXO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[327]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[333]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]

Drug(s) Affected By Histone deacetylase 5 (HDAC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[23]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[603]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[604]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[605]

Drug(s) Affected By DNA replication complex GINS protein PSF2 (GINS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[333]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]

Drug(s) Affected By Heparanase (HPSE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[302]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[606]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[606]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[498]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[389]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[607]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]

Drug(s) Affected By Phospholipase A-2-activating protein (PLAA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[49]
Bortezomib	DMNO38U	Leukemia		Approved	[132]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[55]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]

Drug(s) Affected By Afadin- and alpha-actinin-binding protein (SSX2IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[132]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[608]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[63]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]

Drug(s) Affected By Tudor and KH domain-containing protein (TDRKH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[43]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[583]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[35]

Drug(s) Affected By DNA-directed RNA polymerase III subunit RPC10 (POLR3K)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[595]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[38]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[63]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[475]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[33]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[149]

Drug(s) Affected By Ribosomal RNA-processing protein 7 homolog A (RRP7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[80]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[122]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[470]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[18]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[496]

Drug(s) Affected By RRP15-like protein (RRP15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[69]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[467]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[520]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]

Drug(s) Affected By Nucleolar protein 16 (NOP16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[609]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[90]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]

Drug(s) Affected By Insulin receptor substrate 2 (IRS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[167]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[610]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[611]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[612]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[63]

Drug(s) Affected By Leucine-rich repeat-containing protein 42 (LRRC42)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[266]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[496]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[547]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[82]

Drug(s) Affected By Origin recognition complex subunit 6 (ORC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]

Drug(s) Affected By Stonin-1 (STON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[130]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[34]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
RAC-alpha serine/threonine-protein kinase (AKT1)	TTWTSCV	AKT1_HUMAN	Modulator	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
(3R)-3-hydroxyacyl-CoA dehydrogenase (HSD17B8)	OTX1DWEF	DHB8_HUMAN	Gene/Protein Processing	[5]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (PLCD1)	OT6WFVXZ	PLCD1_HUMAN	Gene/Protein Processing	[5]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[5]
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7)	OTV7VOV3	DHB7_HUMAN	Gene/Protein Processing	[5]
5-hydroxytryptamine receptor 2B (HTR2B)	OTM1AD9J	5HT2B_HUMAN	Gene/Protein Processing	[5]
5-oxoprolinase (OPLAH)	OTX7S4OW	OPLA_HUMAN	Gene/Protein Processing	[5]
A disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAMTS10)	OTNJ9VSU	ATS10_HUMAN	Gene/Protein Processing	[5]
A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAMTS13)	OTXKH5P9	ATS13_HUMAN	Gene/Protein Processing	[5]
Acetyl-CoA acetyltransferase, cytosolic (ACAT2)	OTZ092ZJ	THIC_HUMAN	Gene/Protein Processing	[5]
Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2)	OTB1FZJU	ACSA_HUMAN	Gene/Protein Processing	[5]

References

• [1] ClinicalTrials.gov (NCT01445587) A Study of GSK2110183 in Subjects With Proteasome Inhibitor Refractory Multiple Myeloma. U.S. National Institutes of Health.
• [2] ClinicalTrials.gov (NCT01531894) Continuation Study of the Oral AKT Inhibitor GSK2110183. U.S. National Institutes of Health.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7890).
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1479).
• [5] Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. doi: 10.1002/cam4.1179. Epub 2017 Sep 27.
• [6] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [7] A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
• [8] Pre-clinical and Clinical Safety Studies of CMX-2043: a cytoprotective lipoic acid analogue for ischaemia-reperfusion injury. Basic Clin Pharmacol Toxicol. 2014 Nov;115(5):456-64.
• [9] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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