Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7US1H)

• Drug Name: EUGENOL Drug Info
• Synonyms: eugenol; 97-53-0; 4-Allyl-2-methoxyphenol; 4-Allylguaiacol; Eugenic acid; Allylguaiacol; Caryophyllic acid; p-Allylguaiacol; p-Eugenol; 2-Methoxy-4-prop-2-enylphenol; Engenol; 2-Methoxy-4-allylphenol; Phenol, 2-methoxy-4-(2-propenyl)-; 1,3,4-Eugenol; 4-Allylcatechol-2-methyl ether; Synthetic eugenol; 2-Methoxy-4-(2-propenyl)phenol; 2-Methoxy-1-hydroxy-4-allylbenzene; 4-Allyl-1-hydroxy-2-methoxybenzene; 1-Hydroxy-2-methoxy-4-allylbenzene; 5-Allylguaiacol; 1-Hydroxy-2-methoxy-4-prop-2-enylbenzene

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 3314
  ChEBI ID: CHEBI:4917
  CAS Number: CAS 97-53-0
  TTD Drug ID: DM7US1H
  INTEDE Drug ID: DR1942

Molecule-Related Drug Atlas

Drug(s) Targeting Androgen receptor messenger RNA (AR mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[10]
BAY 86-5044	DMRZLU4	Breast cancer	2C60-2C65	Phase 2	[11]
TRC-253	DMXI8CD	Prostate cancer	2C82.0	Phase 1/2	[12]
IONIS-AR-2.5Rx	DMF2DMS	Prostate cancer	2C82.0	Phase 1/2	[13]
ISIS-AR	DM8P3N5	Prostate cancer	2C82.0	Phase 1	[14]
EZN-4176	DMNPS59	Prostate cancer	2C82.0	Phase 1	[15]
RU-58841	DMMEAZ2	Acne vulgaris	ED80	Discontinued in Phase 1	[16]
flavone	DMEQH6J	Discovery agent	N.A.	Investigative	[17]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[17]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[17]

Drug(s) Targeting Monoamine oxidase type B (MAO-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selegiline Hydrochloride	DM3VR1L	Parkinson disease	8A00.0	Approved	[18]
Phenelzine	DMHIDUE	Depression	6A70-6A7Z	Approved	[19]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[20]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[21]
Safinamide mesylate	DM0J2ZT	Parkinson disease	8A00.0	Approved	[22]
Rasagiline	DM3WKQ4	Parkinson disease	8A00.0	Approved	[23]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[24]
Pargyline	DMM0HR1	Hypertension	BA00-BA04	Approved	[25]
Indeloxazine	DMWO3N6	Dementia	6D80-6D86	Approved	[26]
Budipine	DMODHQI	Migraine	8A80	Approved	[27]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[28]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[30]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[31]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[34]
Metronidazole	DMTIVEN	Abscess		Approved	[35]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[36]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[37]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A9 (UGT1A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[39]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[42]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[41]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[43]
Nateglinide	DMLK2QH	Diabetic complication	5A2Y	Approved	[41]
Haloperidol	DM96SE0	Delirium		Approved	[41]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A8 (UGT1A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]
Empagliflozin	DMRF9YK	Type-1 diabetes	5A10	Approved	[45]
Darolutamide	DMV7YFT	Prostate cancer	2C82.0	Approved	[46]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[4]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[47]
Chrysin	DM7V2LG	Discovery agent	N.A.	Investigative	[4]
phloretin	DMYA50U	Discovery agent	N.A.	Investigative	[4]
Anthraflavic acid	DMN1YFU	N. A.	N. A.	Investigative	[4]
Cis-4-hydroxytamoxifen	DMRFTB5	N. A.	N. A.	Investigative	[47]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A7 (UGT1A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[44]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[4]
Chrysin	DM7V2LG	Discovery agent	N.A.	Investigative	[4]
phloretin	DMYA50U	Discovery agent	N.A.	Investigative	[4]
Anthraflavic acid	DMN1YFU	N. A.	N. A.	Investigative	[4]

Drug(s) Affected By Glutathione S-transferase A1 (GSTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[48]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[49]
Thiotepa	DMIZKOP	Breast cancer	2C60-2C65	Approved	[50]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[52]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[53]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[54]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[60]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[60]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[61]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[65]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[66]

Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[58]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[70]
Methyldopa	DM5I621	Hypertension	BA00-BA04	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Haloperidol	DM96SE0	Delirium		Approved	[75]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[76]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[79]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[84]
Selenium	DM25CGV	N. A.	N. A.	Approved	[85]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[86]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[87]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[89]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[90]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[93]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[95]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[96]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[97]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[98]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[99]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[100]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[101]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[102]

Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[104]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[110]

Drug(s) Affected By H/ACA ribonucleoprotein complex subunit DKC1 (DKC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[114]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[56]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[115]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[116]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[117]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[118]

Drug(s) Affected By Coagulation factor XIII A chain (F13A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[121]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[122]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[123]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[124]

Drug(s) Affected By Tissue-type plasminogen activator (PLAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[125]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[126]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[127]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[130]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[131]
Fructose	DM43AN2	Vomiting	MD90	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]

Drug(s) Affected By HLA class I histocompatibility antigen, B alpha chain (HLA-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[133]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[134]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[135]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[137]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[138]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[139]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[140]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[141]

Drug(s) Affected By Glycophorin-B (GYPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[5]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[142]

Drug(s) Affected By Procathepsin L (CTSL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[146]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[147]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[148]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[149]

Drug(s) Affected By Transcriptional activator Myb (MYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[150]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[151]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[152]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[150]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[154]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[155]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]

Drug(s) Affected By E3 SUMO-protein ligase EGR2 (EGR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[160]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[161]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[114]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[162]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[62]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[163]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[164]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[163]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[163]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[166]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[170]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[171]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[172]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[175]

Drug(s) Affected By Fos-related antigen 2 (FOSL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[177]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[110]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[178]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[149]

Drug(s) Affected By Platelet glycoprotein 4 (CD36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[182]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[183]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[184]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[179]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[187]

Drug(s) Affected By Diamine acetyltransferase 1 (SAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[188]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[190]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[191]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[191]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[110]

Drug(s) Affected By Bone morphogenetic protein 6 (BMP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[192]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[192]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[193]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[192]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[192]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[192]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[192]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[194]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[192]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[177]

Drug(s) Affected By Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[196]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[56]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[197]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[198]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[199]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[124]

Drug(s) Affected By Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[149]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[203]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[204]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[205]

Drug(s) Affected By Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[208]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[189]
cinnamaldehyde	DMZDUXG	Discovery agent	N.A.	Investigative	[209]

Drug(s) Affected By C-C chemokine receptor type 7 (CCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[211]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[212]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[213]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[212]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[149]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[214]

Drug(s) Affected By Syndecan-2 (SDC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[215]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[217]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[218]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[114]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[219]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[149]

Drug(s) Affected By C-C chemokine receptor type 2 (CCR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[220]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[222]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[185]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[223]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[224]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[225]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[226]

Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[227]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[86]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[229]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[230]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[232]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[86]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]

Drug(s) Affected By Prostaglandin E2 receptor EP3 subtype (PTGER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[89]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[233]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[95]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[124]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[234]
Terbinafine	DMI6HUW	Fungal infection	1F29-1F2F	Approved	[235]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[95]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[5]

Drug(s) Affected By Nicotinamide phosphoribosyltransferase (NAMPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[237]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[238]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[239]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[178]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[110]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[178]

Drug(s) Affected By Large ribosomal subunit protein uL15 (RPL27A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[240]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[105]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[241]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[242]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[5]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[243]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[244]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[245]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[246]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[248]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[250]

Drug(s) Affected By Signal transducer and activator of transcription 5B (STAT5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[252]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[253]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[255]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[256]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[257]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[258]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[259]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[260]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[124]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[261]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[262]

Drug(s) Affected By ADP-ribosylation factor-like protein 4C (ARL4C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[264]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[217]
Bortezomib	DMNO38U	Leukemia		Approved	[161]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[265]

Drug(s) Affected By Inward rectifier potassium channel 2 (KCNJ2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[160]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[114]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[267]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[268]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[267]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[269]

Drug(s) Affected By Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[125]
Selenium	DM25CGV	N. A.	N. A.	Approved	[85]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[192]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[192]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[192]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]

Drug(s) Affected By Kinesin-like protein KIF23 (KIF23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[270]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]

Drug(s) Affected By cAMP-responsive element modulator (CREM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[271]
Bortezomib	DMNO38U	Leukemia		Approved	[161]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[272]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[273]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[116]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[124]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[274]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[196]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[275]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[160]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[217]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[276]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[277]

Drug(s) Affected By Regulator of G-protein signaling 1 (RGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[160]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[121]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[278]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[279]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[277]

Drug(s) Affected By Phosphatidylinositol-binding clathrin assembly protein (PICALM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[280]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[281]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[259]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[282]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[124]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[283]

Drug(s) Affected By Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[284]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[285]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[286]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[237]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]

Drug(s) Affected By Signal transducer and activator of transcription 4 (STAT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[86]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[287]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[190]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[288]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[86]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[86]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[86]

Drug(s) Affected By Disks large-associated protein 5 (DLGAP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[110]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[178]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[178]

Drug(s) Affected By Calcitonin gene-related peptide type 1 receptor (CALCRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[289]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[204]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[124]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[290]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[290]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[5]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[291]

Drug(s) Affected By Rho GTPase-activating protein 17 (ARHGAP17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[292]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[292]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[226]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[136]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[124]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[118]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[291]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[293]

Drug(s) Affected By Embigin (EMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[239]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[177]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[204]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[5]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[294]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[291]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[293]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[295]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[296]

Drug(s) Affected By ATP-binding cassette sub-family A member 6 (ABCA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[287]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[279]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[233]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[273]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[297]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[124]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[298]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[299]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[300]

Drug(s) Affected By Monocarboxylate transporter 10 (SLC16A10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[217]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[149]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[159]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[124]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[290]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[301]

Drug(s) Affected By Interactor protein for cytohesin exchange factors 1 (IPCEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[289]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[301]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[5]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[302]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[291]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[293]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[289]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[303]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[266]

Drug(s) Affected By Nuclear pore complex protein Nup88 (NUP88)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[260]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[273]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[68]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[118]

Drug(s) Affected By Membrane-spanning 4-domains subfamily A member 7 (MS4A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[160]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[278]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[5]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[305]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[306]
MICROCYSTIN-LR	DMTMLRN	Discovery agent	N.A.	Investigative	[307]

Drug(s) Affected By Protein C12orf4 (FERRY3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[226]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[308]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[124]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[290]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[118]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[64]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[5]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[306]

Drug(s) Affected By Septin-11 (SEPTIN11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[237]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[310]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[308]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[124]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[189]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[311]

Drug(s) Affected By Bcl-2-associated transcription factor 1 (BCLAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[281]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[312]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[258]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[313]

Drug(s) Affected By Large ribosomal subunit protein bL35m (MRPL35)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[149]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[314]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[64]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[5]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[293]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[315]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[316]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[160]

Drug(s) Affected By HEAT repeat-containing protein 5B (HEATR5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[124]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[118]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[5]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[318]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[319]

Drug(s) Affected By F-box only protein 9 (FBXO9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[237]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[149]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[260]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[273]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[298]

Drug(s) Affected By Malignant T-cell-amplified sequence 1 (MCTS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[320]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[237]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[149]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[124]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[321]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[5]

Drug(s) Affected By Transcription factor MafG (MAFG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[222]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[110]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]

Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[322]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[323]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[324]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[325]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[196]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[8]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[287]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]

Drug(s) Affected By Transcription factor MafK (MAFK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[326]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[149]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[204]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[298]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[118]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[327]
Ketoprofen	DMRKXPT	Bursitis		Approved	[75]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[328]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[329]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[322]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[330]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[331]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[292]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[309]

Drug(s) Affected By Ferritin light chain (FTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[332]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[333]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[334]
Haloperidol	DM96SE0	Delirium		Approved	[75]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[328]
Selenium	DM25CGV	N. A.	N. A.	Approved	[335]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[336]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[337]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[338]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]

Drug(s) Affected By Extracellular superoxide dismutase (SOD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[339]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[340]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[217]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[327]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[341]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[342]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[343]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[102]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[344]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[345]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[84]
Selenium	DM25CGV	N. A.	N. A.	Approved	[346]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[172]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[347]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]

Drug(s) Affected By Microsomal glutathione S-transferase 1 (MGST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[348]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[349]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[179]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[350]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[217]

Drug(s) Affected By Glucose-6-phosphate 1-dehydrogenase (G6PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[351]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[75]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[352]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[329]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[322]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[237]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[353]

Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[354]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[355]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[179]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[217]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[6]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[178]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[356]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[357]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[358]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[359]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[360]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[89]

Drug(s) Affected By Glutathione peroxidase 3 (GPX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[90]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[237]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[239]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[361]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[362]

Drug(s) Affected By Ferrochelatase, mitochondrial (FECH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[363]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[178]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[178]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[178]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[217]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[6]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[124]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[364]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[365]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[366]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[366]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[364]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[364]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[367]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[368]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]

Drug(s) Affected By NADP-dependent malic enzyme (ME1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[322]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[237]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[178]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[84]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[348]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[322]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[369]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[370]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[371]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[372]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[373]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[322]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[374]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[237]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[292]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[375]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[376]

Drug(s) Affected By 6-phosphogluconate dehydrogenase, decarboxylating (PGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[237]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Methylene blue	DMJAPE7	Acquired methemoglobinemia	3A93	Approved	[377]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[6]

Drug(s) Affected By Metallothionein-1X (MT1X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[343]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[378]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[292]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[379]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[110]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[380]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[364]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[365]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[381]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[364]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[364]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[382]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[383]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[381]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[364]

Drug(s) Affected By Prostaglandin reductase 1 (PTGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[384]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[361]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]

Drug(s) Affected By Sulfiredoxin-1 (SRXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[325]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[385]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[286]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[178]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[110]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[178]

Drug(s) Affected By Transcription factor MafF (MAFF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[62]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[386]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[90]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[237]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[222]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[387]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[93]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[388]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[389]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[390]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[391]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[381]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[392]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[393]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[394]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[395]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[125]
Selenium	DM25CGV	N. A.	N. A.	Approved	[85]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[89]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[86]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[70]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[396]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[397]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[398]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[399]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[102]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[400]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[345]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[192]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[401]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[192]

Drug(s) Affected By C-C motif chemokine 3-like 1 (CCL3L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[85]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[217]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[278]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[269]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[402]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[403]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[404]

Drug(s) Affected By Interleukin-7 receptor subunit alpha (IL7R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[405]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[252]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[239]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[160]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[114]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[279]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[406]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[407]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[395]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[408]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[407]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[385]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[354]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[409]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[407]

Drug(s) Affected By Interleukin-1 receptor type 2 (IL1R2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[323]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[237]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[410]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[259]

Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[76]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[411]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[412]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[413]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[414]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[415]

Drug(s) Affected By Sterol 26-hydroxylase, mitochondrial (CYP27A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[322]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[416]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[90]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[70]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[417]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[239]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[418]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[419]

Drug(s) Affected By Max dimerization protein 1 (MXD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[420]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[421]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[422]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[160]

Drug(s) Affected By Signaling lymphocytic activation molecule (SLAMF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[160]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[149]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[136]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[279]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[302]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[291]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[160]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[343]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[423]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[424]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[425]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[426]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[427]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[292]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[428]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[429]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[430]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[430]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[431]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[432]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[433]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[411]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[285]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[434]

Drug(s) Affected By Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[75]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[273]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[435]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[436]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[437]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[9]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[438]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[439]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[440]

Drug(s) Affected By Aryl hydrocarbon receptor repressor (AHRR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[441]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[442]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[287]
Cotinine	DMCEZ1B	Insecticide	N.A.	Approved	[443]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[240]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[444]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[310]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[216]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[445]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[446]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[447]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[244]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[448]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[449]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[450]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[451]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[452]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[151]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[447]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[453]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[454]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[455]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[456]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[457]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[458]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[459]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[460]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[461]

Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[462]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[463]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[244]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[450]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[248]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[464]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[190]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[364]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[365]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[386]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[364]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[410]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[364]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[465]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[239]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[466]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[467]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[468]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[469]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[280]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]

Drug(s) Affected By Glycerol-3-phosphate acyltransferase 3 (GPAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[196]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[178]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[178]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[470]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[62]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[192]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[373]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[192]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[192]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[86]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[471]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[286]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[192]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[472]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[473]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[474]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[475]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[476]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[412]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[477]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[478]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[479]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[479]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[480]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[481]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[482]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[479]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[479]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[479]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[483]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[484]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[485]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[486]
Fructose	DM43AN2	Vomiting	MD90	Approved	[75]
Ketoprofen	DMRKXPT	Bursitis		Approved	[75]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[487]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[488]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[489]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[490]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[491]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[395]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[192]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[192]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[192]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[248]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[192]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[391]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[492]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[492]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[75]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[493]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[494]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[495]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[496]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[497]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[498]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[172]

Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[395]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[499]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[84]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[500]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[501]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[502]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[503]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]

Drug(s) Affected By Serpin B3 (SERPINB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[504]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[505]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[470]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[217]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[506]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[504]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[291]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[506]

Drug(s) Affected By C-C motif chemokine 20 (CCL20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[395]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[345]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[125]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[86]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[177]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[110]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[507]

Drug(s) Affected By Pro-interleukin-16 (IL16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[508]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[509]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[510]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[506]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[240]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[511]

Drug(s) Affected By Toll-like receptor 4 (TLR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[512]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[513]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[507]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[514]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[512]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[178]

Drug(s) Affected By Transcription factor E2F3 (E2F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[151]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[292]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[515]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[281]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[292]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[510]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[114]

Drug(s) Affected By Transcription factor E2F6 (E2F6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[326]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[149]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[516]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[310]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[308]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[291]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[517]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[345]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[518]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[192]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[192]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[519]
Selenium	DM25CGV	N. A.	N. A.	Approved	[85]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[520]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[521]

Drug(s) Affected By Platelet basic protein (PPBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[522]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[523]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[524]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[524]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[525]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[217]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[526]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[527]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[528]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[529]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[9]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[457]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[530]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[531]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[532]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[9]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[533]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[534]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[535]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[536]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[537]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[538]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[539]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[540]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[541]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[463]

Drug(s) Affected By Integrin beta-1 (ITGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[517]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[76]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[405]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[382]
Fructose	DM43AN2	Vomiting	MD90	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[542]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[215]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[543]
Selenium	DM25CGV	N. A.	N. A.	Approved	[544]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[545]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[546]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[547]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[548]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[237]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[549]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[550]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[551]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[166]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[391]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[427]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[552]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[553]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[553]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[166]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[554]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[555]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[556]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[557]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[75]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[395]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[558]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[559]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[488]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[560]

Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[391]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[427]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[552]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[553]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[287]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[553]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[160]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[561]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[490]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Selenium	DM25CGV	N. A.	N. A.	Approved	[544]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[562]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[563]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[408]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[564]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[565]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[517]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[150]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Selenium	DM25CGV	N. A.	N. A.	Approved	[566]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[567]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[568]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[569]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[190]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[570]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[571]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[572]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[373]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[405]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[573]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[574]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[574]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[575]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[576]

Drug(s) Affected By Epithelial cell adhesion molecule (EPCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[569]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[190]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[287]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[114]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[219]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[149]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[577]

Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[343]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[499]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[578]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[427]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[579]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[392]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[110]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[343]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[280]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[580]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[382]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[581]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[323]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[292]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[342]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[582]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[499]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[583]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[584]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[229]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[585]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[248]

Drug(s) Affected By Integrin-binding sialoprotein (IBSP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[586]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[587]
Calcidiol	DMN4CV5	Hypophosphatemia		Approved	[586]
Magnesium	DMU4ORS	Ischemic stroke	8B11.5Z	Approved	[588]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[589]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[590]
GSK2816126	DMJDVW4	Solid tumour/cancer	2A00-2F9Z	Phase 1	[591]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[291]
alpha-ketoglutaric acid	DM5LFYN	Discovery agent	N.A.	Investigative	[592]

Drug(s) Affected By Potassium voltage-gated channel subfamily A member 5 (KCNA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[593]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Pergolide mesylate	DM5GKOV	N. A.	N. A.	Approved	[594]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[214]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[595]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[216]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[596]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[596]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[596]

Drug(s) Affected By Integrin alpha-6 (ITGA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[597]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[598]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[340]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[287]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[599]

Drug(s) Affected By Signal transducer CD24 (CD24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[227]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[367]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[190]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[600]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[190]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[114]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[601]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[602]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[411]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[548]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[603]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[604]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[605]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[606]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[607]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[608]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[609]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[610]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[611]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[612]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[613]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[614]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[192]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[615]

Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[616]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[617]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[618]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[512]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[618]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[274]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[618]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[177]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[619]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[620]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[621]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[537]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[622]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[623]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[624]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[625]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[626]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[627]

Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[628]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[629]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[630]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[239]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[631]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[632]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[114]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[633]

Drug(s) Affected By C-C chemokine receptor type 5 (CCR5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[634]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[635]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[636]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[637]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[638]
I3C	DMIGFOR	Breast cancer	2C60-2C65	Phase 3	[639]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[279]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[640]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[638]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[160]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[561]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[499]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[641]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[642]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[643]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[643]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[229]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[644]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[645]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[646]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[647]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[395]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[559]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[648]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[649]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[423]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[650]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[651]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[652]

Drug(s) Affected By Beta-2-microglobulin (B2M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[653]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[320]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[654]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[655]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[656]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[657]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[658]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[659]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[395]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[660]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[661]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[662]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[450]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[382]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]

Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[567]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[663]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[190]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[570]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[664]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[665]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[666]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[667]

Drug(s) Affected By Interleukin-18 (IL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[517]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[668]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[669]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[670]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[287]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[671]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[672]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[671]

Drug(s) Affected By Transcription factor E2F2 (E2F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[395]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[151]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[190]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[673]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[110]

Drug(s) Affected By Transcription factor E2F5 (E2F5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[673]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[510]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[114]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[674]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[149]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[675]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[344]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[499]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[676]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[359]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[677]

Drug(s) Affected By Transcription factor E2F4 (E2F4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[678]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[679]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[308]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[124]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[680]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[681]

Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[682]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[682]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[239]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[178]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[361]

Drug(s) Affected By Heat shock protein 105 kDa (HSPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[391]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[286]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[292]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[673]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[503]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[392]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[287]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[113]

Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[683]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[684]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[685]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[686]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[687]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[688]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[689]
Mestranol	DMG3F94	Contraception	QA21	Approved	[690]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[691]

Drug(s) Affected By C-C motif chemokine 13 (CCL13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[692]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[426]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[323]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[122]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[693]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[291]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[693]

Drug(s) Affected By C-C motif chemokine 19 (CCL19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[280]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[694]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[695]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[136]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[403]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[160]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[696]

Drug(s) Affected By Tumor protein 63 (TP63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[266]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[697]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[698]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[699]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[700]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[240]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[149]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[701]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]

Drug(s) Affected By Programmed cell death 1 ligand 1 (CD274)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[472]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[702]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[280]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[703]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[177]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[110]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[704]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]

Drug(s) Affected By DnaJ homolog subfamily B member 4 (DNAJB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[343]
Selenium	DM25CGV	N. A.	N. A.	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[391]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[286]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[292]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[274]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[376]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[503]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]

Drug(s) Affected By C-type lectin domain family 4 member A (CLEC4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[278]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[136]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[291]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[293]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[316]
cinnamaldehyde	DMZDUXG	Discovery agent	N.A.	Investigative	[705]

Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[706]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[707]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[708]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[709]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[710]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[711]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[712]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[713]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[714]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[715]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Androgen receptor messenger RNA (AR mRNA)	TTKPW01	ANDR_HUMAN	Inhibitor	[2]
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Substrate	[4]
UDP-glucuronosyltransferase 1A9 (UGT1A9)	DE85D2P	UD19_HUMAN	Substrate	[4]
UDP-glucuronosyltransferase 1A8 (UGT1A8)	DE2GB8N	UD18_HUMAN	Substrate	[4]
UDP-glucuronosyltransferase 1A7 (UGT1A7)	DEZO4N3	UD17_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)	OTOA8WU2	PDE4B_HUMAN	Gene/Protein Processing	[5]
6-phosphogluconate dehydrogenase, decarboxylating (PGD)	OTVG296F	6PGD_HUMAN	Gene/Protein Processing	[6]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[7]
ADP-ribosylation factor-like protein 4C (ARL4C)	OTQ3QNNU	ARL4C_HUMAN	Gene/Protein Processing	[5]
Aldo-keto reductase family 1 member B1 (AKR1B1)	OTRX72TH	ALDR_HUMAN	Gene/Protein Processing	[6]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Gene/Protein Processing	[6]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[6]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[8]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Gene/Protein Processing	[6]
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)	OTG7J4BP	PPBT_HUMAN	Gene/Protein Processing	[9]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2425).
• [2] Effect of essential oils, such as raspberry ketone and its derivatives, on antiandrogenic activity based on in vitro reporter gene assay. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2111-4.
• [3] Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110.
• [4] Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41.
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