Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCT3I8)

• Drug Name: Ifosfamide Drug Info
• Synonyms: Cyfos; Holoxan; Ifex; Ifosfamid; Ifosfamida; Ifosfamidum; Ifosphamide; Ifsofamide; Iphosphamid; Iphosphamide; Isoendoxan; Isofosfamide; Isophosphamide; Isosfamide; Mitoxana; Naxamide; Ifosfamide Sterile; Iso Endoxan; A 4942; ASTA Z 4942; Holoxan 1000; MJF 9325; Z 4942; Z4942; I-Phosphamide; IFEX (TN); Ifex (TN); Ifosfamida [INN-Spanish]; Ifosfamidum [INN-Latin]; Iphosphamid(e); Iso-Endoxan; MJF-9325; Mitoxana (TN); NPFAPI-04; Z-4942; Mitoxana, Ifex, Ifosfamide; Ifosfamide (JAN/USP/INN); Ifosfamide [USAN:INN:BAN:JAN]; N,N-Bis(beta-chloroethyl)-amino-N',O-propylene-phosphoric acid ester diamide; N,3-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide; N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide; N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylen ephosphoric acid diamide; N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylene phosphoric acid ester diamide; N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylenephosphoric acid diamide; N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide; N-(2-Chloraethyl)-N'-(2-chloraethyl)-N',O-propylen-phosphorsaureester-diamid; N-(2-Chloraethyl)-N'-(2-chloraethyl)-N',O-propylen-phosphorsaureester-diamid [German]; N-(2-Chloroethyl)-N-(3-(2-chloroethyl)-2-oxido-1,3,2-oxazaphosphinan-2-yl)amine; (+-)-Ifosfamid; (+-)-Ifosphamide; (+-)-Tetrahydro-N,3-bis(2-chloroethyl)-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide; (D,L)-Ifosfamide; (R,S)-Ifosphamide; (R,S)-N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide; 1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide; 1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide; 2,3-(N,N(sup 1)-Bis(2-chloroethyl)diamido)-1,3,2-oxazaphosphoridinoxyd; 2,3-N,N(sup 1)-Bis(2-chloroethyl)diamido-1,3,2-oxazaphosphoridinoxyd; 2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis(2-chloroethyl)tetrahydro-, 2-oxide; 2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide; 2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide (8CI); 2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide; 3,} 2-oxazaphosphorine oxide; 3-(2-Chloroethyl)-2-((2-chloroethyl)amino)perhydro-2H-1,3,2-oxazaphosphorine oxide; 3-(2-Chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; 3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,3,2-oxazaphosphorine oxide; 3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,3,2-oxazaphosphorineoxide; 3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide

Indication

Disease Entry	ICD 11	Status	REF
Adult central nervous system germ cell tumor		Approved	[1]
Adult teratoma		Approved	[1]
Advanced cancer	2A00-2F9Z	Approved	[1]
Extragonadal germ cell cancer		Approved	[1]
Extragonadal germ cell tumor		Approved	[1]
Kidney neoplasm		Approved	[1]
Solid tumour/cancer	2A00-2F9Z	Approved	[2]
Testicular germ cell tumor		Approved	[1]
Extragonadal nonseminomatous germ cell tumor		Investigative	[1]
Extragonadal seminoma		Investigative	[1]
Neuroblastoma	2D11.2	Investigative	[1]
Retinoblastoma	2D02.2	Investigative	[1]

• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 3690
  ChEBI ID: CHEBI:5864
  CAS Number: CAS 3778-73-2
  TTD Drug ID: DMCT3I8
  INTEDE Drug ID: DR0855
  ACDINA Drug ID: D01151

Molecule-Related Drug Atlas

Drug(s) Targeting Human Deoxyribonucleic acid (hDNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[13]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[14]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[15]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[16]
Carboplatin	DMG281S	Adenocarcinoma	2D40	Approved	[17]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[18]
Procarbazine	DMIK367	Hodgkin lymphoma	2B30	Approved	[19]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[20]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[21]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[22]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[23]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[24]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[25]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[27]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[29]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[30]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[24]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[4]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[95]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[97]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[98]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[99]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[100]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[101]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[102]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[103]

Drug(s) Metabolized By Cytochrome P450 2A6 (CYP2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[31]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[10]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[27]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Metronidazole	DMTIVEN	Abscess		Approved	[34]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[35]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[10]
Tegafur	DM31ZQM	Solid tumour/cancer	2A00-2F9Z	Approved	[109]
Methoxsalen	DME8FZ9	Cutaneous T-cell lymphoma	2B01	Approved	[110]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[113]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[115]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[116]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[117]

Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[38]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[42]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[44]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[45]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[40]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[95]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[101]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[101]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[104]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[107]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]

Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[46]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[40]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[40]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[10]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[47]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[40]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[40]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[40]
Metronidazole	DMTIVEN	Abscess		Approved	[34]

Drug(s) Metabolized By Cytochrome P450 2C18 (CYP2C18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[10]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[48]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[35]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[49]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[50]
Methadone	DMTW6IU	Advanced cancer	2A00-2F9Z	Approved	[51]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[52]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[10]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[53]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Lansoprazole	DMXYLQ3	Gastric ulcer	DA60	Approved	[88]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[89]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[86]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[94]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[31]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[10]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[55]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[56]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[57]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[54]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[58]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[35]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[81]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[82]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[81]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[83]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[81]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[81]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[81]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[84]
Dabrafenib	DMX6OE3	Melanoma	2C30	Approved	[85]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[86]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[59]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[60]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[10]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[62]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[10]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[63]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[64]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[118]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[99]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[98]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[119]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[120]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[99]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[121]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[98]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[99]

Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[67]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[10]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[68]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[70]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[71]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[72]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[73]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[74]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[122]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[124]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[125]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[126]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[127]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[128]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[129]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[130]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[131]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[132]

Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[75]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[59]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[76]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[77]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[10]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[78]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[79]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[35]

Drug(s) Metabolized By Prostaglandin G/H synthase 1 (COX-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[4]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[4]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[4]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[4]
Nateglinide	DMLK2QH	Diabetic complication	5A2Y	Approved	[4]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[4]
Ketobemidone	DMM3L6Z	Pain	MG30-MG3Z	Approved	[4]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[4]
Terbinafine	DMI6HUW	Fungal infection	1F29-1F2F	Approved	[4]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[117]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[98]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[122]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[119]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[99]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[123]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[99]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[117]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[12]

Drug(s) Affected By Beta-2-microglobulin (B2M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[137]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[140]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[141]

Drug(s) Affected By Alpha-2A adrenergic receptor (ADRA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[142]
Rilmenidine	DM13PQW	Hypertension	BA00-BA04	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[145]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Oxymetazoline	DM8ZXT6	Arrhythmia	BC9Z	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Indapamide	DMGN1PW	Edema	MG29	Approved	[149]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[150]

Drug(s) Affected By Interleukin-19 (IL19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[152]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[152]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[152]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[153]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[154]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[155]

Drug(s) Affected By Solute carrier family 12 member 8 (SLC12A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[113]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[158]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[159]

Drug(s) Affected By Toll-like receptor 4 (TLR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[165]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[166]

Drug(s) Affected By Agrin (AGRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[168]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[169]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[170]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[171]

Drug(s) Affected By Podocalyxin (PODXL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[174]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[176]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[11]

Drug(s) Affected By Class E basic helix-loop-helix protein 40 (BHLHE40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[179]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[180]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]

Drug(s) Affected By TRAF-type zinc finger domain-containing protein 1 (TRAFD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[11]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[186]
Bortezomib	DMNO38U	Leukemia		Approved	[187]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[188]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[189]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[190]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[192]
Selenium	DM25CGV	N. A.	N. A.	Approved	[193]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[188]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[194]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[194]

Drug(s) Affected By Rho guanine nucleotide exchange factor 10 (ARHGEF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[11]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[196]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[197]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[142]

Drug(s) Affected By Protein phosphatase 1D (PPM1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[198]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[200]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[202]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]

Drug(s) Affected By Apoptosis regulatory protein Siva (SIVA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[190]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Bortezomib	DMNO38U	Leukemia		Approved	[204]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]

Drug(s) Affected By Transcription factor MafG (MAFG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[207]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]

Drug(s) Affected By D-3-phosphoglycerate dehydrogenase (PHGDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[209]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[145]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]

Drug(s) Affected By E3 ubiquitin-protein ligase SIAH2 (SIAH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[211]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[211]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[213]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]

Drug(s) Affected By Protein regulator of cytokinesis 1 (PRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[214]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]

Drug(s) Affected By TP53-regulated inhibitor of apoptosis 1 (TRIAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[11]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[215]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[11]

Drug(s) Affected By 5'-AMP-activated protein kinase subunit beta-2 (PRKAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]

Drug(s) Affected By Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[219]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[86]

Drug(s) Affected By NUAK family SNF1-like kinase 1 (NUAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[11]

Drug(s) Affected By High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[11]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]

Drug(s) Affected By Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[221]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[159]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[222]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[154]

Drug(s) Affected By PR domain zinc finger protein 1 (PRDM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[223]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[224]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[225]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]

Drug(s) Affected By E3 ubiquitin-protein ligase listerin (LTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[226]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[11]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[227]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 8 (TNFAIP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[228]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[229]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[230]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]

Drug(s) Affected By Tetraspanin-12 (TSPAN12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[197]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[142]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[232]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[222]

Drug(s) Affected By G1/S-specific cyclin-E2 (CCNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[233]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[234]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[188]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[235]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[237]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[202]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[238]
Ketoprofen	DMRKXPT	Bursitis		Approved	[12]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[239]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[240]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[241]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[242]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[243]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[228]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[245]

Drug(s) Affected By Metallothionein-2 (MT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[248]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[249]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[250]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[228]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[251]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]

Drug(s) Affected By Fructose-bisphosphate aldolase A (ALDOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[252]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[253]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[254]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[243]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[179]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[213]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[255]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[256]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[257]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[258]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[259]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[260]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[261]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[262]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[263]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[264]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[265]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[266]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[267]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[268]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[269]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[250]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[270]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[271]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[272]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[273]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[274]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[274]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[274]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[119]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[275]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[123]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[276]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[277]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[278]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[12]

Drug(s) Affected By Fatty acid-binding protein, heart (FABP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[279]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[280]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Haloperidol	DM96SE0	Delirium		Approved	[281]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[281]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[282]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[170]
Methamphetamine	DMPM4SK	Anxiety		Approved	[283]

Drug(s) Affected By Transcription factor AP-2-alpha (TFAP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[284]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[211]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[285]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[286]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[284]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[287]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]

Drug(s) Affected By Integrin beta-1 (ITGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[190]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[288]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[289]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[291]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[292]
Fructose	DM43AN2	Vomiting	MD90	Approved	[293]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[294]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[295]

Drug(s) Affected By Glycogen phosphorylase, liver form (PYGL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[296]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[11]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[170]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[219]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[297]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[228]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[298]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[299]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[198]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[299]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[221]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[300]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[299]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]

Drug(s) Affected By Keratin, type I cytoskeletal 19 (KRT19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[288]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[301]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[302]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[302]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[223]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[287]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]

Drug(s) Affected By Gamma-enolase (ENO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[303]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[304]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[305]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[306]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[307]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[298]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[308]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[309]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[252]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[250]

Drug(s) Affected By RNA-binding protein RO60 (RO60)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[145]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[11]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[310]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[311]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[312]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[280]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[281]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[313]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[313]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[219]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]

Drug(s) Affected By DNA topoisomerase 1 (TOP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[12]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[198]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[314]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[315]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[296]

Drug(s) Affected By Cation-independent mannose-6-phosphate receptor (IGF2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[316]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[213]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[296]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[317]

Drug(s) Affected By Prolyl 4-hydroxylase subunit alpha-1 (P4HA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[318]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[319]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]

Drug(s) Affected By Fos-related antigen 1 (FOSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[301]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[207]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[320]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[321]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[223]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[251]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[323]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[324]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[325]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[326]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[327]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[328]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[329]

Drug(s) Affected By Protein SON (SON)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[198]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[330]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[315]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[308]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[221]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[331]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[332]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[207]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[333]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[334]

Drug(s) Affected By Keratin, type I cytoskeletal 15 (KRT15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[292]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[302]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[302]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[287]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[11]

Drug(s) Affected By Ephrin-A1 (EFNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[335]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[211]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[287]

Drug(s) Affected By Iduronate 2-sulfatase (IDS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[166]

Drug(s) Affected By Ferrochelatase, mitochondrial (FECH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[336]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[208]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]

Drug(s) Affected By Diacylglycerol kinase alpha (DGKA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[301]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[11]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[337]

Drug(s) Affected By Thromboxane-A synthase (TBXAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[338]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[339]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]

Drug(s) Affected By Bromodomain-containing protein 2 (BRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]

Drug(s) Affected By DnaJ homolog subfamily B member 2 (DNAJB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[340]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[341]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[342]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[113]

Drug(s) Affected By Neuropeptide Y receptor type 1 (NPY1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[343]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[94]
Methamphetamine	DMPM4SK	Anxiety		Approved	[344]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[154]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[345]

Drug(s) Affected By Threonine--tRNA ligase 1, cytoplasmic (TARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[281]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[198]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]

Drug(s) Affected By Adenylate kinase 4, mitochondrial (AK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[346]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[297]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[176]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[11]

Drug(s) Affected By ETS domain-containing protein Elk-4 (ELK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[347]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[11]

Drug(s) Affected By Tyrosine-protein kinase receptor UFO (AXL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[348]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[292]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[348]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[349]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]

Drug(s) Affected By 14-3-3 protein sigma (SFN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[233]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[350]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[351]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[348]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[352]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[243]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[348]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[353]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[354]

Drug(s) Affected By Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[281]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[281]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]

Drug(s) Affected By Cystathionine gamma-lyase (CTH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[298]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[145]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[228]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[340]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[223]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[298]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 1 (ACSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[243]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[334]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[356]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]

Drug(s) Affected By Thrombospondin-2 (THBS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[212]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[287]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[165]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[357]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[170]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[298]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[358]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[308]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[191]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[359]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[360]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[361]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[214]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[362]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[363]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[364]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[365]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[366]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[367]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[368]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[369]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[370]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[371]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[372]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[373]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[374]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[375]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[376]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[377]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[378]

Drug(s) Affected By Transaldolase (TALDO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[145]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[379]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[237]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[380]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[289]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[381]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[382]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[383]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[384]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[385]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[188]

Drug(s) Affected By Glycine--tRNA ligase (GARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[350]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[386]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[251]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[387]

Drug(s) Affected By Isoleucine--tRNA ligase, cytoplasmic (IARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[174]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[221]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[251]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 9 (TNFSF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[188]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[348]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[348]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[388]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]

Drug(s) Affected By Eukaryotic translation initiation factor 1 (EIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[380]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[224]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[387]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[11]

Drug(s) Affected By ATP-binding cassette sub-family G member 1 (ABCG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[389]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[243]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[125]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[297]

Drug(s) Affected By Retinaldehyde dehydrogenase 3 (ALDH1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[12]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]

Drug(s) Affected By Sodium- and chloride-dependent glycine transporter 1 (SLC6A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[390]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[11]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[11]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[170]

Drug(s) Affected By NADP-dependent malic enzyme (ME1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[145]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[318]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[208]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[392]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[393]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[241]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[394]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[395]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[396]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[340]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[241]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[397]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[145]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[228]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[353]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[318]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[398]

Drug(s) Affected By Cysteine--tRNA ligase, cytoplasmic (CARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[297]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[295]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[297]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[399]

Drug(s) Affected By Serine--tRNA ligase, cytoplasmic (SARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Haloperidol	DM96SE0	Delirium		Approved	[281]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[281]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[281]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[400]

Drug(s) Affected By Max-interacting protein 1 (MXI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[166]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[401]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[150]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[11]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[402]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[403]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[404]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[402]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[405]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[402]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[406]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]

Drug(s) Affected By Dipeptidyl peptidase 1 (CTSC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[399]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[176]

Drug(s) Affected By Ataxin-1 (ATXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[188]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[226]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]

Drug(s) Affected By Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[315]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[166]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[11]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]

Drug(s) Affected By Homeobox protein DLX-1 (DLX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[11]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[11]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[407]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[408]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[222]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[154]

Drug(s) Affected By Protein BTG2 (BTG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[315]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[409]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[410]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[202]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[224]

Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[411]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[264]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[412]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[413]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[414]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[415]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[190]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[416]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[416]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[417]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[418]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[419]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[257]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[228]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[420]

Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[219]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[145]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[353]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[211]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[421]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[422]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[423]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[288]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[424]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[382]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[425]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[385]

Drug(s) Affected By Transmembrane protein 94 (TMEM94)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[426]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[159]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[427]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[428]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[330]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[330]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[292]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[228]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[429]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[430]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[431]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]

Drug(s) Affected By Zinc finger protein Rlf (RLF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[11]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[342]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[159]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase G (PPIG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[213]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[432]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[433]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[434]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[435]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[221]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[418]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[179]

Drug(s) Affected By Ras-related protein Rab-31 (RAB31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[315]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[11]

Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[436]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[437]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[179]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[438]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[439]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[440]

Drug(s) Affected By Src substrate cortactin (CTTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[441]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[145]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[281]

Drug(s) Affected By Enhancer of filamentation 1 (NEDD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[302]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[302]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[11]

Drug(s) Affected By Protein disulfide-isomerase A5 (PDIA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[11]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[11]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[216]

Drug(s) Affected By Condensin complex subunit 1 (NCAPD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[442]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[357]

Drug(s) Affected By Probable E3 ubiquitin-protein ligase HERC3 (HERC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[11]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[142]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[443]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[444]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[445]

Drug(s) Affected By kinase isozyme 1, mitochondrial (PDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[178]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[446]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[337]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[447]

Drug(s) Affected By Neutral amino acid transporter B(0) (SLC1A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[188]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[188]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[11]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[188]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[448]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[449]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[450]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[308]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[323]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[451]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[326]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[327]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[452]

Drug(s) Affected By Cyclin-G2 (CCNG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[211]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[297]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[211]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[230]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]

Drug(s) Affected By Neuronal regeneration-related protein (NREP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[453]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[318]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[166]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[176]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[454]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[455]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[456]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[456]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[457]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[458]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[459]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[311]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[279]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[460]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[266]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[461]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[462]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[463]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[464]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[465]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[466]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[467]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[453]

Drug(s) Affected By Laminin subunit alpha-3 (LAMA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[302]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[302]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[287]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[442]

Drug(s) Affected By Atos homolog protein A (ATOSA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[178]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[11]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[11]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[407]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[408]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[222]

Drug(s) Affected By Glycerol-3-phosphate acyltransferase 3 (GPAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[437]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[223]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[468]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[399]

Drug(s) Affected By Quinone oxidoreductase PIG3 (TP53I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[418]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[352]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[469]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[420]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[470]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]

Drug(s) Affected By RRP12-like protein (RRP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[330]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[223]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[471]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[472]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]

Drug(s) Affected By ALS2 C-terminal-like protein (ALS2CL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[11]

Drug(s) Affected By Dynamin-binding protein (DNMBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[226]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[472]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[166]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[197]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[142]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[473]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[472]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[222]
PD-0325901	DM27D4J	Breast cancer	2C60-2C65	Phase 2	[474]

Drug(s) Affected By Ribosomal protein eS27-like (RPS27L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[296]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[387]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[11]

Drug(s) Affected By Arginine/serine-rich coiled-coil protein 2 (RSRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[475]

Drug(s) Affected By Mitochondrial enolase superfamily member 1 (ENOSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[476]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[216]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[477]

Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[418]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[478]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[478]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[296]

Drug(s) Affected By Protein LYRIC (MTDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[472]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[479]

Drug(s) Affected By Liprin-beta-1 (PPFIBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[230]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]

Drug(s) Affected By Dynein axonemal intermediate chain 3 (DNAI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[11]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[342]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[480]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[481]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[482]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[479]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[166]

Drug(s) Affected By Extracellular sulfatase Sulf-2 (SULF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]

Drug(s) Affected By Protein O-mannosyl-transferase TMTC2 (TMTC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[230]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[399]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[187]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[483]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[113]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[159]

Drug(s) Affected By Ninein (NIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[484]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[485]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[142]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[159]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[173]

Drug(s) Affected By Ceramide synthase 5 (CERS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[486]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[113]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[154]

Drug(s) Affected By Uncharacterized protein C8orf58 (C8ORF58)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[159]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[222]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[482]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[479]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[487]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[488]

Drug(s) Affected By F-box only protein 22 (FBXO22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[11]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[341]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[142]

Drug(s) Affected By (Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[357]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[489]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[337]

Drug(s) Affected By F-box only protein 30 (FBXO30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[468]

Drug(s) Affected By Pantothenate kinase 1 (PANK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[86]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[11]

Drug(s) Affected By SH3 domain and tetratricopeptide repeat-containing protein 1 (SH3TC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[223]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[230]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[11]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[11]

Drug(s) Affected By Uncharacterized protein C4orf3 (C4ORF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[11]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]
Bortezomib	DMNO38U	Leukemia		Approved	[187]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[159]

Drug(s) Affected By Paraspeckle component 1 (PSPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[490]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[178]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[491]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[492]

Drug(s) Affected By Histone acetyltransferase KAT6B (KAT6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[11]
Bortezomib	DMNO38U	Leukemia		Approved	[187]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[493]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[426]

Drug(s) Affected By E3 ubiquitin-protein ligase rififylin (RFFL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[230]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[387]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX17 (DDX17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[494]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[224]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]

Drug(s) Affected By GTP-binding protein Rit1 (RIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[11]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[489]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[186]
Bortezomib	DMNO38U	Leukemia		Approved	[187]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]

Drug(s) Affected By KICSTOR complex protein ITFG2 (ITFG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[11]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[11]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[197]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[159]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[154]

Drug(s) Affected By Protein TMEPAI (PMEPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[287]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[495]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[170]

Drug(s) Affected By Protein FAM162A (FAM162A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[228]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[228]

Drug(s) Affected By Tumor protein p53-inducible nuclear protein 1 (TP53INP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[418]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[496]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[202]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]

Drug(s) Affected By SPRY domain-containing SOCS box protein 1 (SPSB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[489]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[497]

Drug(s) Affected By Carboxymethylenebutenolidase homolog (CMBL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[11]

Drug(s) Affected By Aurora kinase B (AURKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[380]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[234]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[498]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[499]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]

Drug(s) Affected By Protein FAM89A (FAM89A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[173]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[11]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[500]

Drug(s) Affected By ERO1-like protein alpha (ERO1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[501]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[11]

Drug(s) Affected By Protein FAM210B, mitochondrial (FAM210B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[342]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[142]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[472]

Drug(s) Affected By E1A-binding protein p400 (EP400)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[330]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[11]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[407]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[227]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[502]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[503]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[197]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[232]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[159]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[504]

Drug(s) Affected By ETS-related transcription factor Elf-4 (ELF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[213]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[341]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit C (EIF3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[386]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[505]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[493]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[216]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[298]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[188]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[212]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[506]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[302]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[302]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[507]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[508]

Drug(s) Affected By Cancer-related nucleoside-triphosphatase (NTPCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[11]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[11]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]

Drug(s) Affected By G-protein coupled receptor 87 (GPR87)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[399]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[11]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[113]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[509]

Drug(s) Affected By Sulfiredoxin-1 (SRXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[510]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[511]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]

Drug(s) Affected By G protein-coupled receptor 88 (GPR88)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[113]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[444]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[482]

Drug(s) Affected By Coiled-coil domain-containing protein 90B, mitochondrial (CCDC90B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[166]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[216]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[477]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[512]

Drug(s) Affected By Polyprenol reductase (SRD5A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[11]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[426]

Drug(s) Affected By E3 ubiquitin ligase RNF121 (RNF121)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[90]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[513]

Drug(s) Affected By Ankyrin repeat family A protein 2 (ANKRA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[437]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[166]

Drug(s) Affected By p53-induced death domain-containing protein 1 (PIDD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[188]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[418]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[505]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[11]

Drug(s) Affected By ATP-binding cassette sub-family B member 6 (ABCB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[390]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[514]

Drug(s) Affected By ABC-type oligopeptide transporter ABCB9 (ABCB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[219]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[342]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[197]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[515]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[159]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[222]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[516]

Drug(s) Affected By Fructose-2,6-bisphosphatase TIGAR (TIGAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[188]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[418]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[166]

Drug(s) Affected By Dual specificity protein phosphatase 22 (DUSP22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[341]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[462]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[517]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[479]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[158]

Drug(s) Affected By PAK4-inhibitor INKA2 (INKA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[500]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[341]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[518]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[197]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[142]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[519]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[298]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[188]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[351]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[520]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[228]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[202]

Drug(s) Affected By LIM and cysteine-rich domains protein 1 (LMCD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[230]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[521]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[357]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]

Drug(s) Affected By Signal-induced proliferation-associated 1-like protein 2 (SIPA1L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[522]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[170]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[400]

Drug(s) Affected By Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[170]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]

Drug(s) Affected By DnaJ homolog subfamily B member 9 (DNAJB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[298]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[207]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[523]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[298]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[524]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[399]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[521]

Drug(s) Affected By Mitochondrial fission process protein 1 (MTFP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[197]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[407]

Drug(s) Affected By SERTA domain-containing protein 1 (SERTAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[166]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[11]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]

Drug(s) Affected By Oxidative stress-induced growth inhibitor 1 (OSGIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[11]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[11]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[11]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]

Drug(s) Affected By Heme transporter FLVCR2 (FLVCR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]

Drug(s) Affected By Exocyst complex component 7 (EXOC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[525]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[427]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[154]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[330]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[170]

Drug(s) Affected By 5'-AMP-activated protein kinase subunit beta-1 (PRKAB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[166]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[526]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[188]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[188]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[518]

Drug(s) Affected By Lysine-specific demethylase 3A (KDM3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[437]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[527]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[228]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]

Drug(s) Affected By RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[217]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[197]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[142]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[154]

Drug(s) Affected By Pleckstrin homology-like domain family A member 3 (PHLDA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[166]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[11]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[157]

Drug(s) Affected By Insulin-induced gene 2 protein (INSIG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[230]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[528]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[11]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[196]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[529]

Drug(s) Affected By Phosphoserine aminotransferase (PSAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[298]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[499]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[174]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[298]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[11]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]

Drug(s) Affected By Sestrin-1 (SESN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[323]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[202]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[251]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[175]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[530]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[530]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[531]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[532]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[533]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[530]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[530]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[530]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[534]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[535]

Drug(s) Affected By HLA class I histocompatibility antigen, B alpha chain (HLA-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[536]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[537]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[538]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[426]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[539]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[540]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[541]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[542]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[543]

Drug(s) Affected By Osteocalcin (BGLAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[544]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[545]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[371]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[546]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[547]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[138]
Falecalcitrol	DMBI9ZJ	Hyperparathyroidism	5A51	Approved	[548]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[549]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[550]

Drug(s) Affected By HLA class I histocompatibility antigen, A alpha chain (HLA-A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[551]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[537]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[552]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[553]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[543]
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[554]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[543]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[540]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[540]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[555]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[556]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[557]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[558]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[559]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[560]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[561]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[562]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[563]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[561]

Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain G (HLA-G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[540]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[540]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[315]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[540]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[145]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[540]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[540]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[540]

Drug(s) Affected By Glutathione peroxidase 3 (GPX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[243]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[145]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[296]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[564]

Drug(s) Affected By Major histocompatibility complex class I-related gene protein (MR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[540]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[540]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[540]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[348]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[540]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[540]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[540]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]

Drug(s) Affected By Elastin (ELN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[565]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[566]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[287]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[567]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[357]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[568]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[159]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[445]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[569]

Drug(s) Affected By S-adenosylmethionine decarboxylase proenzyme (AMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[315]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[184]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[205]
Indomethacin	DMSC4A7	Bursitis		Approved	[570]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[571]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[572]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[342]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[573]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[573]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[568]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[252]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[574]

Drug(s) Affected By Ornithine decarboxylase (ODC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[575]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[576]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[577]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[302]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[302]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[508]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[224]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[578]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[579]

Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[580]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[581]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[582]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[583]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[584]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[585]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[119]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[99]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[586]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[587]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human Deoxyribonucleic acid (hDNA)	TTUTN1I	NOUNIPROTAC	Modulator	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[4]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[5]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[6]
Cytochrome P450 2A6 (CYP2A6)	DEJVYAZ	CP2A6_HUMAN	Substrate	[7]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[8]
Cytochrome P450 2B6 (CYP2B6)	DEPKLMQ	CP2B6_HUMAN	Substrate	[9]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[8]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Substrate	[10]
Prostaglandin G/H synthase 1 (COX-1)	DE073H6	PGH1_HUMAN	Substrate	[4]
Cytochrome P450 2C18 (CYP2C18)	DEZMWRE	CP2CI_HUMAN	Substrate	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
(Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4)	OTQK3M9X	ABHD4_HUMAN	Gene/Protein Processing	[11]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Gene/Protein Processing	[11]
5'-AMP-activated protein kinase subunit beta-1 (PRKAB1)	OT1OG4QZ	AAKB1_HUMAN	Gene/Protein Processing	[11]
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2)	OTLVN68B	AAKB2_HUMAN	Gene/Protein Processing	[11]
ABC-type oligopeptide transporter ABCB9 (ABCB9)	OTSOBOL5	ABCB9_HUMAN	Gene/Protein Processing	[11]
Adenylate kinase 4, mitochondrial (AK4)	OTA0T02Q	KAD4_HUMAN	Gene/Protein Processing	[11]
Agrin (AGRN)	OTWJENAZ	AGRIN_HUMAN	Gene/Protein Processing	[11]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[11]
Alpha-2A adrenergic receptor (ADRA2A)	OTZFGOTP	ADA2A_HUMAN	Drug Response	[12]
ALS2 C-terminal-like protein (ALS2CL)	OT8RY7TZ	AL2CL_HUMAN	Gene/Protein Processing	[11]

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