Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWUXDZ)

• Drug Name: Hexadecanoic acid Drug Info
• Synonyms: Palmitic acid; palmitic acid; 1957/10/3; Cetylic acid; palmitate; n-Hexadecanoic acid; Hexadecylic acid; Hydrofol; n-Hexadecoic acid; 1-Pentadecanecarboxylic acid; Pentadecanecarboxylic acid; Palmitinic acid; C16 fatty acid; hexaectylic acid; Industrene 4516; Emersol 143; Emersol 140; Hystrene 8016; Hystrene 9016; 1-Hexyldecanoic Acid; hexadecoic acid; Palmitinsaeure; Palmitic acid (natural); Palmitic acid, pure; Palmitic acid 95%; Prifac 2960; FEMA No 2832; Fatty acids, C14-18; Pristerene 4934; Edenor C16; Kortacid 1698; Lunac P; Palmitic Acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 985
  ChEBI ID: CHEBI:15756
  CAS Number: CAS 57-10-3
  TTD Drug ID: DMWUXDZ

Molecule-Related Drug Atlas

Drug(s) Targeting Fatty acid-binding protein 4 (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID27109571-Compound-27	DMXRTH4	N. A.	N. A.	Patented	[8]
PMID27109571-Compound-31	DMU690T	N. A.	N. A.	Patented	[8]
PMID27109571-Compound-16	DMZI25U	N. A.	N. A.	Patented	[8]
PMID27109571-Compound-14	DMVY6B9	N. A.	N. A.	Patented	[8]
PMID27109571-Compound-25	DM435GR	N. A.	N. A.	Patented	[8]
PMID27109571-Compound-30	DM24FSP	N. A.	N. A.	Patented	[8]
PMID27109571-Compound-29	DMDMEHQ	N. A.	N. A.	Patented	[8]
PMID27109571-Compound-18	DM4S5ME	N. A.	N. A.	Patented	[8]
PMID27109571-Compound-28	DMTZVY3	N. A.	N. A.	Patented	[8]
PMID27109571-Compound-20	DMQU9XP	N. A.	N. A.	Patented	[8]

Drug(s) Targeting Rhodopsin (RHO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[3]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[3]
L-serine-O-phosphate	DMTJ1NH	Discovery agent	N.A.	Investigative	[3]
Phosphonothreonine	DMTFHPI	Discovery agent	N.A.	Investigative	[3]
Beta-D-Mannose	DMHIG9K	Discovery agent	N.A.	Investigative	[3]
NSC-88915	DM9WIHJ	Solid tumour/cancer	2A00-2F9Z	Investigative	[9]
Lauryl Dimethylamine-N-Oxide	DM3W2OE	Discovery agent	N.A.	Investigative	[3]
B-2-Octylglucoside	DMEGX8H	Discovery agent	N.A.	Investigative	[3]
(Hydroxyethyloxy)Tri(Ethyloxy)Octane	DMY6FUD	Discovery agent	N.A.	Investigative	[3]
B-Nonylglucoside	DM48VJR	Discovery agent	N.A.	Investigative	[10]

Drug(s) Targeting Fatty acid-binding protein 5 (FABP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID27109571-Compound-27	DMXRTH4	N. A.	N. A.	Patented	[8]
PMID27109571-Compound-31	DMU690T	N. A.	N. A.	Patented	[8]
PMID27109571-Compound-16	DMZI25U	N. A.	N. A.	Patented	[8]
PMID27109571-Compound-14	DMVY6B9	N. A.	N. A.	Patented	[8]
PMID27109571-Compound-25	DM435GR	N. A.	N. A.	Patented	[8]
PMID27109571-Compound-30	DM24FSP	N. A.	N. A.	Patented	[8]
PMID27109571-Compound-29	DMDMEHQ	N. A.	N. A.	Patented	[8]
PMID27109571-Compound-18	DM4S5ME	N. A.	N. A.	Patented	[8]
PMID27109571-Compound-28	DMTZVY3	N. A.	N. A.	Patented	[8]
PMID27109571-Compound-20	DMQU9XP	N. A.	N. A.	Patented	[8]

Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[13]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[14]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[18]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[19]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[20]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[21]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[22]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[27]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[28]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[24]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[31]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[32]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[33]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[34]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[37]

Drug(s) Affected By Bifunctional epoxide hydrolase 2 (EPHX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[45]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[45]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[46]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[21]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[22]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[24]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[27]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[28]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[48]

Drug(s) Affected By E-selectin (SELE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[49]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[52]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[55]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[56]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[57]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[58]

Drug(s) Affected By Diacylglycerol O-acyltransferase 1 (DGAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[62]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[63]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[64]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]

Drug(s) Affected By Fatty acid-binding protein, liver (FABP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[68]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[67]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[70]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[71]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[73]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[74]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[75]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[78]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[14]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[80]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[81]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[82]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[84]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[85]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[86]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[89]

Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[91]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[92]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[93]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[103]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[106]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[107]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[108]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[109]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[24]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[111]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[95]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[113]

Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[114]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[95]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[116]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[117]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]

Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[106]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[121]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[122]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[125]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[74]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[22]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[126]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[86]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[127]

Drug(s) Affected By Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[95]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[131]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[132]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[134]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[135]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[136]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[137]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[138]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[139]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[140]

Drug(s) Affected By Splicing regulator ARVCF (ARVCF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[144]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[145]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[147]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]

Drug(s) Affected By Nucleolar protein 56 (NOP56)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[152]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[153]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[93]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[154]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[154]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[89]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[154]
Fructose	DM43AN2	Vomiting	MD90	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[154]

Drug(s) Affected By AT-rich interactive domain-containing protein 1A (ARID1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Indomethacin	DMSC4A7	Bursitis		Approved	[157]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[161]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[162]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]

Drug(s) Affected By Suppressor of cytokine signaling 3 (SOCS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[163]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[165]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Fedratinib	DM4ZBK6	Myelofibrosis	2A20.2	Approved	[166]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[166]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[89]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[168]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[169]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[168]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[171]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[172]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[173]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 12A (PPP1R12A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[174]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[175]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[177]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[178]

Drug(s) Affected By ATP-binding cassette sub-family C member 5 (ABCC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[180]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[181]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[182]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[183]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[186]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]

Drug(s) Affected By Cytoplasmic dynein 1 light intermediate chain 2 (DYNC1LI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[187]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[188]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[38]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[189]

Drug(s) Affected By Tumor protein D54 (TPD52L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[190]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[192]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[193]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[194]

Drug(s) Affected By U3 small nucleolar RNA-interacting protein 2 (RRP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[198]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[197]

Drug(s) Affected By Peroxisomal ATPase PEX1 (PEX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[39]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[201]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]

Drug(s) Affected By TBC1 domain family member 4 (TBC1D4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[202]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[203]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[204]

Drug(s) Affected By HMG box-containing protein 1 (HBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[205]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]

Drug(s) Affected By Catenin delta-1 (CTNND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[206]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]

Drug(s) Affected By H/ACA ribonucleoprotein complex subunit DKC1 (DKC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[208]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[209]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]

Drug(s) Affected By Eukaryotic translation initiation factor 5B (EIF5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[188]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[188]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[211]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[212]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[213]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[214]

Drug(s) Affected By Nibrin (NBN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[215]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[217]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[218]

Drug(s) Affected By Auxilin (DNAJC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[220]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[222]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[220]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[223]

Drug(s) Affected By Nuclear receptor corepressor 1 (NCOR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[224]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[163]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[226]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[227]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]

Drug(s) Affected By Sperm-associated antigen 7 (SPAG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[63]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[39]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[63]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[228]

Drug(s) Affected By Vesicle-trafficking protein SEC22b (SEC22B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[229]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[230]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[231]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[228]

Drug(s) Affected By Pre-mRNA-processing factor 40 homolog A (PRPF40A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[198]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[17]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[39]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[214]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 24 (MED24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[233]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[234]

Drug(s) Affected By Multiple PDZ domain protein (MPDZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[235]

Drug(s) Affected By Serine/threonine-protein kinase D3 (PRKD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[236]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[220]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]

Drug(s) Affected By Golgi SNAP receptor complex member 1 (GOSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[91]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[39]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[147]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[238]

Drug(s) Affected By Histone acetyltransferase KAT7 (KAT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[190]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[167]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[167]

Drug(s) Affected By SNARE-associated protein Snapin (SNAPIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[228]

Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[240]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[242]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[219]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[243]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[244]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[246]

Drug(s) Affected By Pericentrin (PCNT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[247]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[248]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]

Drug(s) Affected By E3 ubiquitin-protein ligase HERC2 (HERC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[249]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[228]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[250]
Haloperidol	DM96SE0	Delirium		Approved	[91]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[92]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[251]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[252]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[253]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[255]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[256]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[257]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[91]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[224]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[258]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[260]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[261]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[262]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[263]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]

Drug(s) Affected By Insulin-like growth factor II (IGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[265]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[266]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[267]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[268]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[269]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[270]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[271]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[272]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[273]
Fructose	DM43AN2	Vomiting	MD90	Approved	[91]
Ketoprofen	DMRKXPT	Bursitis		Approved	[91]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[275]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[276]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[277]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[278]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[280]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[75]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[281]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[282]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[282]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[283]
Selenium	DM25CGV	N. A.	N. A.	Approved	[284]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[285]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[286]

Drug(s) Affected By Ferritin heavy chain (FTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[82]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[287]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[85]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[288]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[289]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[290]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[80]

Drug(s) Affected By Metallothionein-2 (MT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[291]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[294]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[295]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[205]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[80]

Drug(s) Affected By Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[296]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[163]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[297]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[298]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[299]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[300]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[301]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[302]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[303]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[304]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[305]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[306]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[307]

Drug(s) Affected By Metallothionein-1E (MT1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[205]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[308]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[309]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[310]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[311]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[312]

Drug(s) Affected By Metallothionein-1F (MT1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[205]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[313]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[202]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[309]

Drug(s) Affected By Cytochrome b-245 heavy chain (CYBB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[314]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[315]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[316]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[17]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[317]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[317]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[318]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[319]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[320]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[321]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[322]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[323]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[324]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[325]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[326]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[327]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[328]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[329]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[330]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[95]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[331]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[219]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[22]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[332]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[334]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[335]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[27]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[336]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[337]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[338]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[339]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[73]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[340]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[75]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[283]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[341]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[338]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[342]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[342]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[91]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[343]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[344]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[345]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[346]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[347]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[348]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[78]

Drug(s) Affected By Keratin, type II cytoskeletal 8 (KRT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[92]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[349]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[350]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[351]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[352]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]

Drug(s) Affected By Glutathione peroxidase 1 (GPX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[353]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[354]
Selenium	DM25CGV	N. A.	N. A.	Approved	[355]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[356]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[357]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[358]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[359]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[360]

Drug(s) Affected By TCF3 fusion partner (TFPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[228]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[361]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[362]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[363]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[73]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[364]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[75]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[282]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[365]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[282]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[340]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[335]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[358]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[366]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[367]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[368]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[368]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[340]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[369]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[370]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[371]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[372]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[91]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[373]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[374]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[275]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[375]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[376]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[377]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[251]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[378]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[379]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[380]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[381]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[382]
Fructose	DM43AN2	Vomiting	MD90	Approved	[155]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[298]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[383]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Haloperidol	DM96SE0	Delirium		Approved	[384]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[385]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[386]

Drug(s) Affected By Serine/threonine-protein kinase B-raf (BRAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[387]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[215]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[388]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[310]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[220]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[389]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[390]

Drug(s) Affected By Zinc finger protein 40 (HIVEP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[391]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[392]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[147]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-7 (ATF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[393]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[214]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[141]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[394]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[335]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[395]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[396]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[397]

Drug(s) Affected By Protein SON (SON)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[332]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[80]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]

Drug(s) Affected By Negative elongation factor E (NELFE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[398]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]

Drug(s) Affected By Regulator of chromosome condensation (RCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[222]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[399]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[400]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[17]

Drug(s) Affected By DNA ligase 1 (LIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[401]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[402]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[403]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[404]

Drug(s) Affected By Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[405]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[407]

Drug(s) Affected By B-cell lymphoma 3 protein (BCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[408]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[387]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[80]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[409]

Drug(s) Affected By Neurofibromin (NF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[205]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[205]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]

Drug(s) Affected By Oxysterol-binding protein 1 (OSBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[410]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[411]

Drug(s) Affected By Cadherin-3 (CDH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[319]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[412]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[413]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[414]

Drug(s) Affected By Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[415]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[416]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[417]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[418]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[419]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[420]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[240]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[421]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[422]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[423]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[424]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[425]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[426]

Drug(s) Affected By Eukaryotic translation initiation factor 4B (EIF4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[427]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[428]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[429]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[17]

Drug(s) Affected By Endothelin-1 receptor (EDNRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Fructose	DM43AN2	Vomiting	MD90	Approved	[430]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[431]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[222]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[92]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[432]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[433]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[434]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[435]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[105]
Fructose	DM43AN2	Vomiting	MD90	Approved	[430]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[436]

Drug(s) Affected By Pentraxin-related protein PTX3 (PTX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[284]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[437]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[202]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[271]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[438]
Bortezomib	DMNO38U	Leukemia		Approved	[439]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]

Drug(s) Affected By DNA cytosine-5)-methyltransferase 1 (DNMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[440]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[441]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[442]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[435]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[443]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[444]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[445]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[446]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[447]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[448]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[449]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[450]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[275]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[451]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[452]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[453]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[454]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[455]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[456]

Drug(s) Affected By 5-hydroxytryptamine receptor 2A (HTR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[91]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[457]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[458]
Haloperidol	DM96SE0	Delirium		Approved	[458]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[459]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[460]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[461]

Drug(s) Affected By Protein ITPRID2 (ITPRID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[46]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[38]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[462]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[393]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[463]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[449]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[464]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[465]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[466]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[448]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[91]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[280]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[275]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[451]

Drug(s) Affected By Myristoylated alanine-rich C-kinase substrate (MARCKS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[338]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[338]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[467]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[351]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]

Drug(s) Affected By CAP-Gly domain-containing linker protein 1 (CLIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[468]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[469]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[38]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[470]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[471]

Drug(s) Affected By Neurotensin receptor type 1 (NTSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[266]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[472]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[233]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[473]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
NEUROTENSIN	DM27WCE	Discovery agent	N.A.	Investigative	[474]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[475]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[476]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[305]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[375]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[477]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[421]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[478]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[109]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[479]

Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Indomethacin	DMSC4A7	Bursitis		Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[480]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[481]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[14]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[482]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[483]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[335]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[484]

Drug(s) Affected By Insulin receptor substrate 1 (IRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[415]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[485]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[486]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]

Drug(s) Affected By Alpha-adducin (ADD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[39]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[487]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[22]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[488]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[32]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[489]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[379]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[91]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[280]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[490]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[491]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[492]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[493]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[494]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[495]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[496]

Drug(s) Affected By Protein phosphatase inhibitor 2 (PPP1R2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[497]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[498]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[213]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[499]

Drug(s) Affected By 5-hydroxytryptamine receptor 2B (HTR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[91]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[500]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[501]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[271]
Bortezomib	DMNO38U	Leukemia		Approved	[502]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[212]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[503]
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[504]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[505]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[506]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[224]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[420]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[240]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[507]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[479]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[508]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[509]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[388]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[510]

Drug(s) Affected By Histidine ammonia-lyase (HAL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[511]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Methoxsalen	DME8FZ9	Cutaneous T-cell lymphoma	2B01	Approved	[512]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[222]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[513]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[514]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[515]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[302]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[516]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[517]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[518]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[519]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[520]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[521]

Drug(s) Affected By RNA-binding protein 34 (RBM34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[522]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[522]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[522]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[203]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[522]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[203]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[522]

Drug(s) Affected By Excitatory amino acid transporter 1 (SLC1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[523]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[46]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[63]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[312]

Drug(s) Affected By Nicotinamide phosphoribosyltransferase (NAMPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[358]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[215]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[524]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[80]

Drug(s) Affected By ATP-binding cassette sub-family G member 1 (ABCG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[525]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[526]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[80]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[80]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[436]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[527]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[528]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[277]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[529]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[530]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[336]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[531]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[529]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[532]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[528]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[319]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[529]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[533]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[534]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[529]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[535]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[536]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[537]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[379]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[402]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[538]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[539]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[540]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[541]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[542]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[543]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[544]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[533]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[545]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[546]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[547]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[548]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[549]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[550]

Drug(s) Affected By Sodium- and chloride-dependent betaine transporter (SLC6A12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[551]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[552]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[366]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[553]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]

Drug(s) Affected By Nuclear pore complex protein Nup153 (NUP153)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[554]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[486]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[202]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[188]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]

Drug(s) Affected By Glycogen synthase kinase-3 alpha (GSK3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[555]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[556]
Methamphetamine	DMPM4SK	Anxiety		Approved	[557]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[558]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[556]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[559]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[555]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[39]

Drug(s) Affected By RNA-binding protein FXR2 (FXR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[560]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[561]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]

Drug(s) Affected By Transcription activator BRG1 (SMARCA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[307]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[205]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[205]

Drug(s) Affected By Hepatoma-derived growth factor (HDGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[190]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[251]

Drug(s) Affected By Arf-GAP domain and FG repeat-containing protein 1 (AGFG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[212]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[393]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[562]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[563]

Drug(s) Affected By Cysteine-rich protein 2 (CRIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Bortezomib	DMNO38U	Leukemia		Approved	[502]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[564]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]

Drug(s) Affected By Pancreas/duodenum homeobox protein 1 (PDX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amiloride	DMRTSGP	Congestive heart failure	BD10	Approved	[565]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[566]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[567]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[568]
Harmine	DMPA5WD	Discovery agent	N.A.	Patented	[569]
D-glucose	DMMG2TO	Discovery agent	N.A.	Investigative	[570]

Drug(s) Affected By Microfibrillar-associated protein 1 (MFAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[237]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[214]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[418]

Drug(s) Affected By Cadherin-15 (CDH15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[571]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[316]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[572]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[411]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[573]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[574]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[575]

Drug(s) Affected By ATP-binding cassette sub-family E member 1 (ABCE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[576]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[188]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[577]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[578]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[147]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein K (HNRNPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[579]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[580]
Haloperidol	DM96SE0	Delirium		Approved	[188]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[581]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[582]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[583]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[580]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[584]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[585]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[425]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[351]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[586]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[587]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[588]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[475]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By General transcription factor II-I (GTF2I)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[502]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[404]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[589]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[393]

Drug(s) Affected By Metallothionein-1H (MT1H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[95]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[205]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[590]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[202]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[309]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[63]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[312]

Drug(s) Affected By Metallothionein-1X (MT1X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[591]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[205]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]

Drug(s) Affected By Brain acid soluble protein 1 (BASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[215]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[592]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[202]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[593]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]

Drug(s) Affected By Hepcidin (HAMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[594]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[341]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[595]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[596]
Papaverine	DMCA9QP	Brain ischaemia	8B1Z	Approved	[596]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[597]

Drug(s) Affected By Disabled homolog 2 (DAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[598]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[599]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[131]

Drug(s) Affected By AMP deaminase 2 (AMPD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[600]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[417]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[197]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[234]

Drug(s) Affected By Protein kinase C epsilon type (PRKCE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[601]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[95]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[167]
Indomethacin	DMSC4A7	Bursitis		Approved	[602]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[503]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]

Drug(s) Affected By Caveolin-1 (CAV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[375]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[163]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[454]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[603]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[604]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[605]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[590]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[606]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[280]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[375]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[607]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[608]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[601]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[609]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[610]

Drug(s) Affected By Copper-transporting ATPase 1 (ATP7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[395]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[611]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[612]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[613]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[614]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[614]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[614]

Drug(s) Affected By Glutamate decarboxylase 2 (GAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[615]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[615]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[393]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[615]
Chlorphrifos oxon	DMGBT68	Discovery agent	N.A.	Investigative	[615]
CHLORPYRIFOS	DMKPUI6	Discovery agent	N.A.	Investigative	[615]
PARAOXON	DMN4ZKC	Discovery agent	N.A.	Investigative	[615]

Drug(s) Affected By Protein kinase C delta type (PRKCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[205]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[616]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[617]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[618]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[619]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[620]

Drug(s) Affected By 2-5A-dependent ribonuclease (RNASEL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[415]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[269]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[621]

Drug(s) Affected By Exosome complex component RRP45 (EXOSC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[211]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[237]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[213]

Drug(s) Affected By Sperm-associated antigen 1 (SPAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[486]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[501]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[571]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[369]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[521]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[373]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[92]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[622]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[623]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[319]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[624]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[625]

Drug(s) Affected By Calmodulin-regulated spectrin-associated protein 2 (CAMSAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[229]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[393]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[213]

Drug(s) Affected By Neuroblast differentiation-associated protein AHNAK (AHNAK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[332]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[202]

Drug(s) Affected By Nexilin (NEXN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[412]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[438]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[63]

Drug(s) Affected By General transcription factor 3C polypeptide 1 (GTF3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[249]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[214]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[572]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[141]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[574]
geraniol	DMS3CBD	Discovery agent	N.A.	Investigative	[626]

Drug(s) Affected By A-kinase anchor protein 13 (AKAP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[627]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[628]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[418]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[629]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 3 (CHD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[630]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[222]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[631]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[234]

Drug(s) Affected By TP53-binding protein 1 (TP53BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[269]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[632]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[633]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[634]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[635]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]

Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[420]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[435]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[113]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[298]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[215]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[636]

Drug(s) Affected By Chromatin assembly factor 1 subunit A (CHAF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[522]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[522]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[637]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]

Drug(s) Affected By Serine/threonine-protein kinase PAK 2 (PAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[409]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[220]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]

Drug(s) Affected By Chromobox protein homolog 3 (CBX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[202]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[112]
Bortezomib	DMNO38U	Leukemia		Approved	[502]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]

Drug(s) Affected By Ras GTPase-activating protein-binding protein 1 (G3BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[638]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[202]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[589]

Drug(s) Affected By Treacle protein (TCOF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[402]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[633]

Drug(s) Affected By Splicing factor 3B subunit 2 (SF3B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[214]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[639]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[640]

Drug(s) Affected By Golgin subfamily A member 4 (GOLGA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[562]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[189]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[469]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[189]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[641]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[219]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[642]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[643]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[644]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[224]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[420]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[645]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[646]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[647]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[174]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[14]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[648]

Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[649]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[479]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[650]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[576]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[651]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[415]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[587]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[428]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]

Drug(s) Affected By Apoptosis-stimulating of p53 protein 2 (TP53BP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[409]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[652]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[653]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[194]

Drug(s) Affected By Nuclear receptor coactivator 4 (NCOA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[654]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[655]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[656]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]

Drug(s) Affected By Bystin (BYSL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[652]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[43]

Drug(s) Affected By Src substrate cortactin (CTTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[657]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[215]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[80]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]

Drug(s) Affected By Beclin-1 (BECN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[658]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[507]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[14]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[242]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[659]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[660]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[661]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[662]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[588]

Drug(s) Affected By Mediator of DNA damage checkpoint protein 1 (MDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Bortezomib	DMNO38U	Leukemia		Approved	[502]

Drug(s) Affected By Ribosomal RNA processing protein 1 homolog B (RRP1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[568]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[663]

Drug(s) Affected By Nucleolar and coiled-body phosphoprotein 1 (NOLC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[38]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[211]

Drug(s) Affected By Condensin complex subunit 1 (NCAPD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[80]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[664]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]

Drug(s) Affected By Plectin (PLEC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[188]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[562]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[665]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[666]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[80]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[80]

Drug(s) Affected By Prostaglandin E synthase 3 (PTGES3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[667]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[213]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[213]

Drug(s) Affected By Interferon regulatory factor 4 (IRF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[668]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[669]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Bortezomib	DMNO38U	Leukemia		Approved	[670]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[671]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[672]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[673]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[674]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By RalA-binding protein 1 (RALBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[388]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[675]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[676]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[677]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]

Drug(s) Affected By Nuclear receptor coactivator 2 (NCOA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[163]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[678]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[222]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[163]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[393]

Drug(s) Affected By Probable JmjC domain-containing histone demethylation protein 2C (JMJD1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[290]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[202]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[213]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[214]

Drug(s) Affected By Intersectin-1 (ITSN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[213]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[147]

Drug(s) Affected By Serine/threonine-protein kinase STK11 (STK11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[420]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[679]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[680]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[681]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[682]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[145]
GDC-0980/RG7422	DMF3MV1	Non-hodgkin lymphoma	2B33.5	Phase 2	[683]

Drug(s) Affected By Coiled-coil domain-containing protein 6 (CCDC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[562]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Bortezomib	DMNO38U	Leukemia		Approved	[502]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[684]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[685]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[125]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[686]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[687]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[539]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[532]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[688]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[689]

Drug(s) Affected By Drebrin (DBN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[215]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[366]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[690]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[229]

Drug(s) Affected By Nuclear factor interleukin-3-regulated protein (NFIL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[174]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[379]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]

Drug(s) Affected By kinase isozyme 4, mitochondrial (PDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[142]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[691]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[692]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[117]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[80]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[80]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]

Drug(s) Affected By 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[648]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[205]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[174]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[693]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[205]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein U-like protein 2 (HNRNPUL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[562]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[236]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[393]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[694]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[194]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]

Drug(s) Affected By Centrosome and spindle pole-associated protein 1 (CSPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[695]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[167]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Indomethacin	DMSC4A7	Bursitis		Approved	[157]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[212]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[696]

Drug(s) Affected By Ral GTPase-activating protein subunit alpha-2 (RALGAPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[413]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[393]

Drug(s) Affected By Ankyrin repeat domain-containing protein SOWAHC (SOWAHC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[697]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[627]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]

Drug(s) Affected By Cordon-bleu protein-like 1 (COBLL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[695]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[469]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[63]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]

Drug(s) Affected By Protein PRRC2B (PRRC2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[222]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[393]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[249]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[214]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[572]

Drug(s) Affected By Cytospin-B (SPECC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[222]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]

Drug(s) Affected By Protein FAM83B (FAM83B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[486]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[296]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[249]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[147]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[141]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[228]

Drug(s) Affected By FK506-binding protein 15 (FKBP15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Methamphetamine	DMPM4SK	Anxiety		Approved	[698]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[141]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[202]

Drug(s) Affected By Transcription factor Gibbin (AHDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[214]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[147]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]

Drug(s) Affected By Regulation of nuclear pre-mRNA domain-containing protein 2 (RPRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[194]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]

Drug(s) Affected By Disabled homolog 2-interacting protein (DAB2IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[486]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[699]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[700]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By ORC ubiquitin ligase 1 (OBI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[213]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[214]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]

Drug(s) Affected By F-box/WD repeat-containing protein 9 (FBXW9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[582]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[147]

Drug(s) Affected By ADP-ribosylation factor-like protein 6-interacting protein 4 (ARL6IP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]

Drug(s) Affected By Ragulator complex protein LAMTOR1 (LAMTOR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]

Drug(s) Affected By Keratin, type II cytoskeletal 80 (KRT80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[396]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[396]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[415]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[438]

Drug(s) Affected By Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (JMJD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[211]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[677]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[145]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[234]

Drug(s) Affected By Protein FAM117B (FAM117B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[415]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[701]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]

Drug(s) Affected By RNA polymerase-associated protein CTR9 homolog (CTR9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[702]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[212]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]

Drug(s) Affected By La-related protein 1 (LARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
G1	DMTV42K	Lymphoma	2A80-2A86	Phase 1/2	[589]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[214]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By Suprabasin (SBSN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[703]
Octanal	DMTN0OK	N. A.	N. A.	Investigative	[575]

Drug(s) Affected By Activating transcription factor 7-interacting protein 1 (ATF7IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[212]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]

Drug(s) Affected By Zinc finger protein AEBP2 (AEBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[704]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Indomethacin	DMSC4A7	Bursitis		Approved	[157]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[705]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[147]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[574]

Drug(s) Affected By Nucleolar protein 8 (NOL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[229]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[652]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[39]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[214]

Drug(s) Affected By Putative Polycomb group protein ASXL2 (ASXL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[706]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[228]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[269]

Drug(s) Affected By ATP-dependent RNA helicase DHX29 (DHX29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[147]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[141]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[228]
1,6-hexamethylene diisocyanate	DMLB3RT	Discovery agent	N.A.	Investigative	[707]

Drug(s) Affected By E3 ubiquitin-protein ligase HUWE1 (HUWE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[230]
AMG 176	DM0Q7NO	Acute myeloid leukaemia	2A60	Phase 1	[708]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[249]
AZD5991	DM7QGHO	Haematological malignancy	2B33.Y	Phase 1	[708]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[572]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]

Drug(s) Affected By Uncharacterized protein C11orf96 (C11ORF96)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[702]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[709]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[630]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]

Drug(s) Affected By Pleckstrin homology-like domain family B member 2 (PHLDB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[486]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[152]

Drug(s) Affected By Protein LYRIC (MTDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[80]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[80]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[237]

Drug(s) Affected By B-cell CLL/lymphoma 9-like protein (BCL9L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[710]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[471]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[214]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[63]

Drug(s) Affected By Glucocorticoid-induced transcript 1 protein (GLCCI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]

Drug(s) Affected By Proline and serine-rich protein 2 (PROSER2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[46]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[571]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]

Drug(s) Affected By Mitotic interactor and substrate of PLK1 (MISP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]

Drug(s) Affected By Serine/arginine repetitive matrix protein 1 (SRRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[399]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[393]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[631]

Drug(s) Affected By Oxidation resistance protein 1 (OXR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[462]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[81]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[711]

Drug(s) Affected By Male-specific lethal 3 homolog (MSL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[167]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[712]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[167]

Drug(s) Affected By ATP-binding cassette sub-family F member 1 (ABCF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[552]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[237]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[141]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[418]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[713]

Drug(s) Affected By Biorientation of chromosomes in cell division protein 1-like 1 (BOD1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[563]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[469]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[563]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[227]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[393]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[563]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]

Drug(s) Affected By Torsin-1A-interacting protein 2 (TOR1AIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[562]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[572]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]

Drug(s) Affected By RB1-inducible coiled-coil protein 1 (RB1CC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[714]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[469]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[501]
Bortezomib	DMNO38U	Leukemia		Approved	[502]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[715]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[198]

Drug(s) Affected By Histone-lysine N-methyltransferase, H3 lysine-79 specific (DOT1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[634]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[212]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[147]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[574]

Drug(s) Affected By Protein Shroom3 (SHROOM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[412]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[269]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[438]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[152]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]

Drug(s) Affected By Fibroblast growth factor receptor substrate 2 (FRS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[716]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[269]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[220]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[393]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[220]
AZD4547	DM3827C	Solid tumour/cancer	2A00-2F9Z	Phase 2/3	[475]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[147]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]

Drug(s) Affected By RNA polymerase-associated protein LEO1 (LEO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[214]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]

Drug(s) Affected By Protein POF1B (POF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[296]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[269]

Drug(s) Affected By PEST proteolytic signal-containing nuclear protein (PCNP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[190]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[188]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[188]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[393]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[147]

Drug(s) Affected By LIM domain only protein 7 (LMO7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[560]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[577]

Drug(s) Affected By Piezo-type mechanosensitive ion channel component 1 (PIEZO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Cerulenin	DM6N4PR	Weight loss	MG43.5	Approved	[717]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[237]

Drug(s) Affected By TBC1 domain family member 5 (TBC1D5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[693]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[237]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[17]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[718]

Drug(s) Affected By A-kinase anchor protein 1, mitochondrial (AKAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[269]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[398]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[163]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[167]

Drug(s) Affected By Transcription factor AP-2 gamma (TFAP2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[719]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[719]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[695]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Mestranol	DMG3F94	Contraception	QA21	Approved	[719]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[720]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[719]

Drug(s) Affected By Zinc finger protein ubi-d4 (DPF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[409]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[470]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[214]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[721]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX17 (DDX17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[722]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[290]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[80]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[723]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[521]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[280]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[724]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[725]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[265]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[726]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[727]

Drug(s) Affected By Myocardin-related transcription factor A (MRTFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[606]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[167]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]

Drug(s) Affected By Far upstream element-binding protein 1 (FUBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[728]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[188]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[729]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]

Drug(s) Affected By Proline-rich AKT1 substrate 1 (AKT1S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[475]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[502]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cabazitaxel	DMPAZHC	Breast cancer	2C60-2C65	Approved	[730]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[589]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]

Drug(s) Affected By EF-hand domain-containing protein D2 (EFHD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[731]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[589]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[316]

Drug(s) Affected By BTB/POZ domain-containing protein KCTD12 (KCTD12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[215]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[695]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[486]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[732]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[188]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[188]

Drug(s) Affected By Mdm2-binding protein (MTBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[271]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[631]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[249]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[456]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[733]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[734]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[735]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[736]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[737]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[738]

Drug(s) Affected By Enhancer of mRNA-decapping protein 3 (EDC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[498]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[739]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]

Drug(s) Affected By RCC1-like G exchanging factor-like protein (RCC1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[202]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[571]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[568]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[228]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[574]
AM251	DMTAWHL	Discovery agent	N.A.	Investigative	[740]

Drug(s) Affected By Dedicator of cytokinesis protein 7 (DOCK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[229]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[144]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[167]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[705]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[141]

Drug(s) Affected By Serine/threonine-protein kinase SMG1 (SMG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[207]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[222]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[741]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[742]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[743]

Drug(s) Affected By Ankyrin repeat and SOCS box protein 2 (ASB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[462]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[744]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[316]

Drug(s) Affected By Sodium-coupled neutral amino acid symporter 2 (SLC38A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[745]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[551]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[205]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[552]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[594]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[746]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[747]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[748]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[219]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[746]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[747]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[749]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By RNA-binding protein 15 (RBM15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[562]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[750]
Indomethacin	DMSC4A7	Bursitis		Approved	[157]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[751]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[237]

Drug(s) Affected By Bifunctional polynucleotide phosphatase/kinase (PNKP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[752]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[753]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]

Drug(s) Affected By Glutamate decarboxylase 1 (GAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[445]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[615]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[754]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[755]

Drug(s) Affected By Sortilin (SORT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[188]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[215]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[756]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[63]

Drug(s) Affected By Metastasis-associated protein MTA3 (MTA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[152]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[222]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[757]

Drug(s) Affected By Ashwin (C2ORF49)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[167]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[36]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[147]

Drug(s) Affected By Replication initiator 1 (REPIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[438]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[571]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[758]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[235]

Drug(s) Affected By Kanadaptin (SLC4A1AP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[712]

Drug(s) Affected By Bcl-2-like protein 13 (BCL2L13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[280]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[759]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[462]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[398]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
Duvelisib	DM7USVA	Follicular lymphoma	2A80	Phase 2 Trial	[760]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]

Drug(s) Affected By Protein BEX2 (BEX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[761]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[762]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[663]

Drug(s) Affected By ATP-binding cassette sub-family A member 2 (ABCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[552]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[571]
Bortezomib	DMNO38U	Leukemia		Approved	[502]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[316]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[763]

Drug(s) Affected By 182 kDa tankyrase-1-binding protein (TNKS1BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[188]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[764]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]

Drug(s) Affected By ATP-dependent RNA helicase DDX24 (DDX24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[80]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[212]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[39]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[214]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]

Drug(s) Affected By Rac GTPase-activating protein 1 (RACGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[332]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[765]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[758]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[664]

Drug(s) Affected By Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[766]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[229]
Bortezomib	DMNO38U	Leukemia		Approved	[502]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[767]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[768]

Drug(s) Affected By Activity-dependent neuroprotector homeobox protein (ADNP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Indomethacin	DMSC4A7	Bursitis		Approved	[157]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[247]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[214]

Drug(s) Affected By Cdc42 effector protein 4 (CDC42EP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[594]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[202]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[594]

Drug(s) Affected By ESF1 homolog (ESF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Bortezomib	DMNO38U	Leukemia		Approved	[502]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[212]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[393]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[214]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[568]

Drug(s) Affected By Splicing factor, arginine/serine-rich 19 (SCAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[574]

Drug(s) Affected By Tensin-1 (TNS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[769]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]

Drug(s) Affected By Mitochondrial dynamics protein MIEF1 (MIEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[770]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[231]

Drug(s) Affected By Anillin (ANLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[379]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[761]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[664]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]

Drug(s) Affected By E3 ubiquitin-protein ligase RAD18 (RAD18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[771]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[393]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[505]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[214]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[705]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[456]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[336]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[244]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[336]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[772]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[244]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[773]

Drug(s) Affected By Midasin (MDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[202]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[227]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]

Drug(s) Affected By Protein BEX4 (BEX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[212]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[774]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[575]

Drug(s) Affected By MICOS complex subunit MIC19 (CHCHD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[630]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[627]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[705]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]

Drug(s) Affected By Bcl-2-associated transcription factor 1 (BCLAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[202]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[693]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[775]

Drug(s) Affected By BET1-like protein (BET1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[637]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[38]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[411]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]

Drug(s) Affected By G2 and S phase-expressed protein 1 (GTSE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[401]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[402]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[761]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[310]

Drug(s) Affected By Constitutive coactivator of PPAR-gamma-like protein 1 (FAM120A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[562]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[711]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[147]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]

Drug(s) Affected By Denticleless protein homolog (DTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[776]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[202]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[637]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[271]

Drug(s) Affected By Rho guanine nucleotide exchange factor 12 (ARHGEF12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[227]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[237]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[777]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[141]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[574]

Drug(s) Affected By CCR4-NOT transcription complex subunit 2 (CNOT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[695]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[418]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[770]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[778]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[141]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[779]

Drug(s) Affected By Very-long-chain (HACD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[188]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[188]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
EMODIN	DMAEDQG	Coronavirus Disease 2019 (COVID-19)	1D6Y	Terminated	[780]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[231]

Drug(s) Affected By Disco-interacting protein 2 homolog B (DIP2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[705]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[774]

Drug(s) Affected By Ribosome-binding protein 1 (RRBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[695]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[175]
Haloperidol	DM96SE0	Delirium		Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[188]

Drug(s) Affected By Homologous-pairing protein 2 homolog (PSMC3IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[522]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[484]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[522]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[637]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[781]
Fructose	DM43AN2	Vomiting	MD90	Approved	[155]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[383]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[734]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[782]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[783]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[783]

Drug(s) Affected By Spastin (SPAST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[147]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[228]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[269]

Drug(s) Affected By Solute carrier family 23 member 2 (SLC23A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[551]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[552]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[784]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[502]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[438]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[221]

Drug(s) Affected By LIM domain and actin-binding protein 1 (LIMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[785]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[202]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Bortezomib	DMNO38U	Leukemia		Approved	[502]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]

Drug(s) Affected By Septin-9 (SEPTIN9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[786]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[701]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[234]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[787]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[147]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX20 (DDX20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]

Drug(s) Affected By Drebrin-like protein (DBNL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[788]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[627]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[411]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[231]

Drug(s) Affected By G patch domain-containing protein 8 (GPATCH8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[39]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[214]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[228]

Drug(s) Affected By Apoptotic chromatin condensation inducer in the nucleus (ACIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[190]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[511]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[229]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[220]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[789]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]

Drug(s) Affected By Nuclear pore complex protein Nup50 (NUP50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[188]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[188]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[188]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[211]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 5 (ACSL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[95]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[215]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[790]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[791]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[46]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[63]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[709]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]

Drug(s) Affected By Synergin gamma (SYNRG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[393]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[721]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[228]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[779]

Drug(s) Affected By Protein NDRG2 (NDRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[769]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[63]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[699]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]

Drug(s) Affected By LIM and calponin homology domains-containing protein 1 (LIMCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[215]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[486]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[693]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[46]

Drug(s) Affected By Coronin-2B (CORO2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[393]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[43]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[147]

Drug(s) Affected By Serine/arginine repetitive matrix protein 2 (SRRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[188]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]

Drug(s) Affected By Phospholipid-transporting ATPase IF (ATP11B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[296]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[393]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[677]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[563]

Drug(s) Affected By 1-phosphatidylinositol 3-phosphate 5-kinase (PIKFYVE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[17]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[568]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[147]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[141]

Drug(s) Affected By Protein SGT1 homolog (SUGT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[151]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]

Drug(s) Affected By Coiled-coil domain-containing protein 9 (CCDC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[571]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]

Drug(s) Affected By DmX-like protein 1 (DMXL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[792]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[793]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[792]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[469]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[229]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]

Drug(s) Affected By Centrosomal protein of 170 kDa protein B (CEP170B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[147]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]

Drug(s) Affected By Rap guanine nucleotide exchange factor 2 (RAPGEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[236]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[563]

Drug(s) Affected By Beta/gamma crystallin domain-containing protein 1 (CRYBG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[794]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[709]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]

Drug(s) Affected By NADPH oxidase 1 (NOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[637]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[795]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[317]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[317]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[796]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[317]
Acteoside	DM0YHKB	Nephritis	GB40	Terminated	[797]
U0126	DM31OGF	Discovery agent	N.A.	Investigative	[798]

Drug(s) Affected By DnaJ homolog subfamily C member 15 (DNAJC15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[215]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[220]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[799]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[800]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[220]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[43]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[147]

Drug(s) Affected By Cytoplasmic dynein 1 light intermediate chain 1 (DYNC1LI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[188]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[188]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[393]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[148]

Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[562]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[801]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[116]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[802]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[803]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[150]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[804]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[805]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[227]

Drug(s) Affected By Glutaminase kidney isoform, mitochondrial (GLS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[396]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[205]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[486]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[806]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[91]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[807]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[808]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[809]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[109]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[810]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[811]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[812]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[813]

Drug(s) Affected By Insulin (INS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[814]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[815]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[816]
Fructose	DM43AN2	Vomiting	MD90	Approved	[817]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[818]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[819]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[820]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[821]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[822]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fatty acid-binding protein 4 (FABP4)	TTHWMFZ	FABP4_HUMAN	Inhibitor	[2]
Fatty acid-binding protein 5 (FABP5)	TTNT2S6	FABP5_HUMAN	Inhibitor	[2]
Rhodopsin (RHO)	TTH0KSX	OPSD_HUMAN	Inhibitor	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 3-phosphate 5-kinase (PIKFYVE)	OTO3HGAA	FYV1_HUMAN	Post-Translational Modifications	[4]
182 kDa tankyrase-1-binding protein (TNKS1BP1)	OTBIZECQ	TB182_HUMAN	Post-Translational Modifications	[4]
2-5A-dependent ribonuclease (RNASEL)	OTP6UQUP	RN5A_HUMAN	Gene/Protein Processing	[5]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)	OT7TNF0L	AAPK1_HUMAN	Biotransformations	[6]
5-hydroxytryptamine receptor 2A (HTR2A)	OTWXJX0M	5HT2A_HUMAN	Gene/Protein Processing	[7]
5-hydroxytryptamine receptor 2B (HTR2B)	OTM1AD9J	5HT2B_HUMAN	Gene/Protein Processing	[7]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)	OT25JBA3	F263_HUMAN	Post-Translational Modifications	[4]
A-kinase anchor protein 1, mitochondrial (AKAP1)	OTIIB2JB	AKAP1_HUMAN	Post-Translational Modifications	[4]
A-kinase anchor protein 13 (AKAP13)	OTOZAR14	AKP13_HUMAN	Post-Translational Modifications	[4]
Abscission/NoCut checkpoint regulator	OT6V9IDI	ANCHR_HUMAN	Post-Translational Modifications	[4]

References

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• [3] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [4] Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism. Hepatology. 2017 Aug;66(2):432-448. doi: 10.1002/hep.29033. Epub 2017 Jun 16.
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• [6] Dual inhibition of glutaminase and carnitine palmitoyltransferase decreases growth and migration of glutaminase inhibition-resistant triple-negative breast cancer cells. J Biol Chem. 2019 Jun 14;294(24):9342-9357.
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