General Information of Drug Combination (ID: DC4REU9)

Drug Combination Name
Fulvestrant Bortezomib
Indication
Disease Entry Status REF
Metastatic Breast Carcinoma Phase 1 [1]
Component Drugs Fulvestrant   DM0YZC6 Bortezomib   DMNO38U
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Fulvestrant
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Approved [2]
Fulvestrant Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Estrogen receptor (ESR) TTZAYWL ESR1_HUMAN Antagonist [14]
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Fulvestrant Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [15]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [16]
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Fulvestrant Interacts with 985 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Increases Expression [7]
Transferrin receptor protein 1 (TFRC) OT8ZPBDL TFR1_HUMAN Increases Expression [7]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [7]
Integrin beta-1 (ITGB1) OT6G1IAR ITB1_HUMAN Increases Expression [7]
Macrophage colony-stimulating factor 1 (CSF1) OT68M7RD CSF1_HUMAN Increases Expression [7]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Increases Expression [7]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Increases Expression [7]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Increases Expression [7]
Ephrin type-A receptor 1 (EPHA1) OTGJMRZ0 EPHA1_HUMAN Increases Expression [7]
Proteinase-activated receptor 1 (F2R) OT4WVWBO PAR1_HUMAN Increases Expression [7]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [7]
Caspase-4 (CASP4) OTVQTV1L CASP4_HUMAN Increases Expression [7]
Dual specificity protein kinase CLK1 (CLK1) OTG1LACW CLK1_HUMAN Increases Expression [7]
Ras-related protein Rab-2A (RAB2A) OT6SK83U RAB2A_HUMAN Increases Expression [7]
CCHC-type zinc finger nucleic acid binding protein (CNBP) OTTGM9NK CNBP_HUMAN Increases Expression [7]
Dynein light chain 1, cytoplasmic (DYNLL1) OTR69LHT DYL1_HUMAN Increases Expression [7]
Paired box protein Pax-5 (PAX5) OTYBJJWX PAX5_HUMAN Increases Expression [7]
GA-binding protein alpha chain (GABPA) OT9YB2SA GABPA_HUMAN Increases Expression [7]
Mitogen-activated protein kinase kinase kinase 11 (MAP3K11) OT0EYZAY M3K11_HUMAN Increases Expression [7]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Expression [6]
ATP-binding cassette sub-family C member 5 (ABCC5) OT34G4US MRP5_HUMAN Decreases Expression [6]
Transforming acidic coiled-coil-containing protein 1 (TACC1) OTGX20TE TACC1_HUMAN Increases Expression [6]
Cystatin-A (CSTA) OT1K68KE CYTA_HUMAN Decreases Expression [6]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Decreases Expression [6]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [6]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Increases Expression [6]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Decreases Expression [6]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [6]
Ephrin-A1 (EFNA1) OTU2NUA2 EFNA1_HUMAN Increases Expression [6]
Insulin-like growth factor-binding protein 4 (IGFBP4) OT2HZRBD IBP4_HUMAN Decreases Expression [6]
Insulin receptor substrate 1 (IRS1) OTNO82CU IRS1_HUMAN Decreases Expression [6]
CCN family member 3 (CCN3) OTOW5YL4 CCN3_HUMAN Increases Expression [6]
Matrix metalloproteinase-15 (MMP15) OT1XF517 MMP15_HUMAN Increases Expression [6]
Neprilysin (MME) OT5Q39P8 NEP_HUMAN Increases Expression [17]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Increases Expression [17]
Amphiregulin (AREG) OTJFOR67 AREG_HUMAN Decreases Expression [17]
Trefoil factor 3 (TFF3) OTJJDRTU TFF3_HUMAN Decreases Expression [17]
Interferon-related developmental regulator 1 (IFRD1) OT4SQMLQ IFRD1_HUMAN Decreases Expression [8]
26S proteasome non-ATPase regulatory subunit 14 (PSMD14) OTJWHMZ5 PSDE_HUMAN Decreases Expression [8]
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Decreases Expression [8]
Protein phosphatase 1D (PPM1D) OT8NLZ9D PPM1D_HUMAN Decreases Expression [8]
ATP-dependent RNA helicase DDX3Y (DDX3Y) OTKL1FNX DDX3Y_HUMAN Decreases Expression [8]
Asparagine--tRNA ligase, cytoplasmic (NARS1) OTFS4J1W SYNC_HUMAN Decreases Expression [8]
Trafficking kinesin-binding protein 2 (TRAK2) OTXVA7FN TRAK2_HUMAN Decreases Expression [8]
Calsyntenin-1 (CLSTN1) OTQN35G2 CSTN1_HUMAN Decreases Expression [8]
Kinesin-like protein KIF20A (KIF20A) OTXOQHE0 KI20A_HUMAN Decreases Expression [8]
Apolipoprotein D (APOD) OTT77XW8 APOD_HUMAN Increases Expression [8]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Decreases Expression [8]
Nucleophosmin (NPM1) OTTBYYT0 NPM_HUMAN Decreases Expression [8]
Heat shock protein HSP 90-beta (HSP90AB1) OTR69EG7 HS90B_HUMAN Decreases Expression [8]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Decreases Expression [8]
Matrix Gla protein (MGP) OTZWU3FU MGP_HUMAN Decreases Expression [8]
High mobility group protein B1 (HMGB1) OT4B7CPF HMGB1_HUMAN Decreases Expression [8]
Pro-cathepsin H (CTSH) OTLFL0DG CATH_HUMAN Increases Expression [8]
60 kDa heat shock protein, mitochondrial (HSPD1) OTTO1Y11 CH60_HUMAN Decreases Expression [8]
Heat shock cognate 71 kDa protein (HSPA8) OTJI2RCI HSP7C_HUMAN Decreases Expression [8]
DNA topoisomerase 1 (TOP1) OT51O0CF TOP1_HUMAN Decreases Expression [8]
Endoplasmin (HSP90B1) OT02XLBR ENPL_HUMAN Decreases Expression [8]
Stathmin (STMN1) OTDJ4RV0 STMN1_HUMAN Decreases Expression [8]
Protein SON (SON) OT9VWV18 SON_HUMAN Decreases Expression [8]
Nucleolin (NCL) OTBXPKMP NUCL_HUMAN Decreases Expression [8]
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) OTBZKX4P ROA2_HUMAN Decreases Expression [8]
Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1) OTGP6GA4 NR4A1_HUMAN Increases Expression [8]
Splicing factor, proline- and glutamine-rich (SFPQ) OTLCIAPJ SFPQ_HUMAN Decreases Expression [8]
Ribonucleoside-diphosphate reductase large subunit (RRM1) OTXGQOR9 RIR1_HUMAN Decreases Expression [8]
Signal transducer CD24 (CD24) OT7CODJ4 CD24_HUMAN Increases Expression [8]
Threonine--tRNA ligase 1, cytoplasmic (TARS1) OT0PWST5 SYTC_HUMAN Decreases Expression [8]
DNA-directed RNA polymerase II subunit RPB2 (POLR2B) OTS3F0H2 RPB2_HUMAN Decreases Expression [8]
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) OTFRWOLM HNRH1_HUMAN Decreases Expression [8]
Heat shock 70 kDa protein 4 (HSPA4) OT5HR0AR HSP74_HUMAN Decreases Expression [8]
Thrombospondin-2 (THBS2) OTXET551 TSP2_HUMAN Decreases Expression [8]
Coatomer subunit beta' (COPB2) OT82JIGC COPB2_HUMAN Decreases Expression [8]
Lamina-associated polypeptide 2, isoform alpha (TMPO) OTL68EL4 LAP2A_HUMAN Decreases Expression [8]
Signal transducer and activator of transcription 1-alpha/beta (STAT1) OTLMBUZ6 STAT1_HUMAN Decreases Expression [8]
Matrin-3 (MATR3) OTESJ5S7 MATR3_HUMAN Decreases Expression [8]
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) OTZRWTGA IQGA1_HUMAN Decreases Expression [8]
Histone H3-like centromeric protein A (CENPA) OT0NEJ4X CENPA_HUMAN Decreases Expression [8]
Sulfate transporter (SLC26A2) OTJNHNTO S26A2_HUMAN Decreases Expression [8]
Importin subunit alpha-1 (KPNA2) OTU7FOE6 IMA1_HUMAN Decreases Expression [8]
Eukaryotic translation initiation factor 5 (EIF5) OT79PQUN IF5_HUMAN Decreases Expression [8]
Ras-related protein Rap-1A (RAP1A) OT5RH6TI RAP1A_HUMAN Decreases Expression [8]
DNA-dependent protein kinase catalytic subunit (PRKDC) OTJVS4EG PRKDC_HUMAN Decreases Expression [8]
Chromobox protein homolog 1 (CBX1) OT2L4XZX CBX1_HUMAN Decreases Expression [8]
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) OTLQN1E2 HNRPU_HUMAN Decreases Expression [8]
Large ribosomal subunit protein eL6 (RPL6) OTRU71O4 RL6_HUMAN Decreases Expression [8]
DNA topoisomerase 2-beta (TOP2B) OTDHKQZ8 TOP2B_HUMAN Decreases Expression [8]
Serine/arginine-rich splicing factor 1 (SRSF1) OTF61HOV SRSF1_HUMAN Decreases Expression [8]
ATP-dependent RNA helicase A (DHX9) OT5AAOQI DHX9_HUMAN Decreases Expression [8]
Neuroblast differentiation-associated protein AHNAK (AHNAK) OT6KH1WG AHNK_HUMAN Decreases Expression [8]
Zinc transporter ZIP6 (SLC39A6) OTCYF466 S39A6_HUMAN Decreases Expression [8]
Importin subunit beta-1 (KPNB1) OTBT2HFL IMB1_HUMAN Decreases Expression [8]
Proteasome activator complex subunit 4 (PSME4) OTDGF53O PSME4_HUMAN Decreases Expression [8]
Condensin complex subunit 2 (NCAPH) OTXOS97C CND2_HUMAN Decreases Expression [8]
PCNA-associated factor (PCLAF) OTMVIOUU PAF15_HUMAN Decreases Expression [8]
26S proteasome non-ATPase regulatory subunit 6 (PSMD6) OTX59EGK PSMD6_HUMAN Decreases Expression [8]
Elongin-B (ELOB) OTZ3X84T ELOB_HUMAN Decreases Expression [8]
Histone-binding protein RBBP7 (RBBP7) OTLB56HX RBBP7_HUMAN Decreases Expression [8]
Transcription initiation factor TFIID subunit 9 (TAF9) OTCTH3C6 TAF9_HUMAN Decreases Expression [8]
Golgin subfamily A member 5 (GOLGA5) OTG6HB6U GOGA5_HUMAN Decreases Expression [8]
Transportin-1 (TNPO1) OT7W2CM8 TNPO1_HUMAN Decreases Expression [8]
Dehydrodolichyl diphosphate synthase complex subunit NUS1 (NUS1) OT4DQ82L NGBR_HUMAN Decreases Expression [8]
UAP56-interacting factor (FYTTD1) OTXXKQJR UIF_HUMAN Decreases Expression [8]
Rac GTPase-activating protein 1 (RACGAP1) OTQE8IEH RGAP1_HUMAN Decreases Expression [8]
Protein ILRUN (ILRUN) OTE8FHQD ILRUN_HUMAN Decreases Expression [8]
Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) OTAQD3YV ARNT2_HUMAN Increases Expression [8]
Nucleolar RNA helicase 2 (DDX21) OTV73GMZ DDX21_HUMAN Decreases Expression [8]
Very long chain fatty acid elongase 5 (ELOVL5) OT375W1Z ELOV5_HUMAN Decreases Expression [8]
Serine/threonine-protein kinase 26 (STK26) OTW4QE0D STK26_HUMAN Decreases Expression [8]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Increases Expression [18]
Serine/threonine-protein kinase Sgk1 (SGK1) OT301T1U SGK1_HUMAN Decreases Expression [9]
Prostaglandin E synthase (PTGES) OTB7YQFU PTGES_HUMAN Decreases Expression [9]
E3 ubiquitin-protein ligase SIAH2 (SIAH2) OTKED2XN SIAH2_HUMAN Decreases Expression [9]
Carbonic anhydrase 12 (CA12) OT6WNFU8 CAH12_HUMAN Decreases Expression [9]
Tyrosine-protein kinase JAK2 (JAK2) OTBIDOOR JAK2_HUMAN Decreases Expression [9]
monooxygenase MICAL2 (MICAL2) OT04OQQJ MICA2_HUMAN Decreases Expression [9]
Transcription factor AP-2-alpha (TFAP2A) OTMYT3NK AP2A_HUMAN Increases Expression [9]
Proto-oncogene tyrosine-protein kinase receptor Ret (RET) OTLU040A RET_HUMAN Decreases Expression [9]
Monoacylglycerol lipase ABHD2 (ABHD2) OTCRUOCS ABHD2_HUMAN Decreases Expression [9]
Transcriptional activator Myb (MYB) OTJH64IV MYB_HUMAN Decreases Expression [9]
Myb-related protein A (MYBL1) OTBJMC2P MYBA_HUMAN Decreases Expression [9]
Tissue factor pathway inhibitor (TFPI) OTA0FX16 TFPI1_HUMAN Increases Expression [9]
Delta-aminolevulinic acid dehydratase (ALAD) OTHM9GSH HEM2_HUMAN Increases Expression [9]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Decreases Expression [9]
Stromal cell-derived factor 1 (CXCL12) OT2QX5LL SDF1_HUMAN Decreases Expression [9]
Ephrin type-A receptor 4 (EPHA4) OT3AMK0C EPHA4_HUMAN Increases Expression [9]
Single-stranded DNA-binding protein 2 (SSBP2) OTYG1G80 SSBP2_HUMAN Increases Expression [9]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Decreases Expression [9]
DNA-binding protein inhibitor ID-3 (ID3) OTUULW5Z ID3_HUMAN Increases Expression [9]
Urokinase plasminogen activator surface receptor (PLAUR) OTIRKKEQ UPAR_HUMAN Decreases Expression [9]
Early growth response protein 3 (EGR3) OTGPJIRA EGR3_HUMAN Decreases Expression [9]
Forkhead box protein C1 (FOXC1) OTOWZGYO FOXC1_HUMAN Decreases Expression [9]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Increases Expression [9]
Kynureninase (KYNU) OTINL2RE KYNU_HUMAN Increases Expression [9]
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (PDZK1) OTGFK4MH NHRF3_HUMAN Decreases Expression [9]
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) OTXGJ8N1 P55G_HUMAN Increases Expression [9]
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) OTMDVWPS DYRK2_HUMAN Increases Expression [9]
Transcription factor AP-2 gamma (TFAP2C) OTUDIW05 AP2C_HUMAN Decreases Expression [9]
Serine/threonine-protein kinase Sgk3 (SGK3) OTQ6QO99 SGK3_HUMAN Decreases Expression [9]
Inactive rhomboid protein 1 (RHBDF1) OTCQ7UDS RHDF1_HUMAN Increases Expression [9]
Calmin (CLMN) OT7U5J3T CLMN_HUMAN Increases Expression [9]
DNA endonuclease RBBP8 (RBBP8) OTRHJ3GI CTIP_HUMAN Decreases Expression [9]
Noelin (OLFM1) OTOYPEWW NOE1_HUMAN Decreases Expression [9]
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) OTBGDG8C PKHF2_HUMAN Increases Expression [9]
Spermine oxidase (SMOX) OT11E62Y SMOX_HUMAN Decreases Expression [9]
Nicotinamide riboside kinase 1 (NMRK1) OT0STQLV NRK1_HUMAN Decreases Expression [9]
Rap guanine nucleotide exchange factor-like 1 (RAPGEFL1) OTYKE9ZM RPGFL_HUMAN Decreases Expression [9]
RNA 3'-terminal phosphate cyclase-like protein (RCL1) OT7O00YX RCL1_HUMAN Decreases Expression [9]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Increases Expression [19]
Extended synaptotagmin-3 (ESYT3) OTG5H3YF ESYT3_HUMAN Increases Methylation [10]
FERM domain-containing protein 3 (FRMD3) OT0CD2GG FRMD3_HUMAN Increases Methylation [10]
Dystrotelin (DYTN) OTC5QZ6R DYTN_HUMAN Increases Methylation [10]
Coiled-coil domain-containing protein 144A (CCDC144A) OTN9UZHR C144A_HUMAN Decreases Methylation [10]
Transmembrane protein 89 (TMEM89) OTZLX09R TMM89_HUMAN Increases Methylation [10]
Delphilin (GRID2IP) OTNDNC0W GRD2I_HUMAN Increases Methylation [10]
Paralemmin-3 (PALM3) OTB83R61 PALM3_HUMAN Increases Methylation [10]
Rho GTPase-activating protein 42 (ARHGAP42) OTIDSJMK RHG42_HUMAN Increases Methylation [10]
Ciliary microtubule inner protein 2C (CIMIP2C) OTKXQKQ4 CMI2C_HUMAN Increases Methylation [10]
Fidgetin-like protein 2 (FIGNL2) OT0GD7S6 FIGL2_HUMAN Increases Methylation [10]
Dorsal root ganglia homeobox protein (DRGX) OTDLEGNE DRGX_HUMAN Increases Methylation [10]
Uncharacterized protein C12orf71 (C12ORF71) OTUFA24U CL071_HUMAN Increases Methylation [10]
Uncharacterized protein C16orf90 (C16ORF90) OTAYN87M CP090_HUMAN Increases Methylation [10]
Isthmin-1 (ISM1) OTZTK2TV ISM1_HUMAN Increases Methylation [10]
Rab GTPase-activating protein 1-like, isoform 10 (RABGAP1L) OT7QO47I RBG10_HUMAN Increases Methylation [10]
Uncharacterized protein C19orf84 (C19ORF84) OT4MVCU6 CS084_HUMAN Increases Methylation [10]
Golgi-associated olfactory signaling regulator (GFY) OTM64CSN GFY_HUMAN Increases Methylation [10]
ATP-dependent RNA helicase DDX39A (DDX39A) OT0Z6E1K DX39A_HUMAN Increases Methylation [10]
Cytosolic acyl coenzyme A thioester hydrolase (ACOT7) OT7C68YV BACH_HUMAN Increases Methylation [10]
Synaptosomal-associated protein 23 (SNAP23) OTY2MYBX SNP23_HUMAN Increases Methylation [10]
Splicing regulator ARVCF (ARVCF) OT78DKOU ARVC_HUMAN Increases Methylation [10]
AP-3 complex subunit beta-1 (AP3B1) OTYTIH5Q AP3B1_HUMAN Decreases Expression [12]
E3 ubiquitin-protein ligase RNF103 (RNF103) OT9DOB4H RN103_HUMAN Increases Methylation [10]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) OTQ4W7MT TR11B_HUMAN Increases Expression [12]
Importin-5 (IPO5) OTAK40ED IPO5_HUMAN Increases Methylation [10]
Histone deacetylase complex subunit SAP18 (SAP18) OTJAZWOL SAP18_HUMAN Increases Methylation [10]
Nuclear receptor subfamily 5 group A member 2 (NR5A2) OTXAUJAS NR5A2_HUMAN Increases Expression [12]
Serine/threonine-protein kinase 25 (STK25) OT4YPNTF STK25_HUMAN Increases Methylation [10]
Receptor-binding cancer antigen expressed on SiSo cells (EBAG9) OTTQLQCP RCAS1_HUMAN Decreases Expression [12]
Pro-neuregulin-2, membrane-bound isoform (NRG2) OTMDE844 NRG2_HUMAN Increases Methylation [10]
Homeobox protein cut-like 2 (CUX2) OTDJTQAJ CUX2_HUMAN Increases Methylation [10]
Suppressor of cytokine signaling 3 (SOCS3) OTY183WJ SOCS3_HUMAN Decreases Expression [12]
Olfactory receptor 7A17 (OR7A17) OTFYB5NE OR7AH_HUMAN Increases Methylation [10]
Telomerase reverse transcriptase (TERT) OT085VVA TERT_HUMAN Decreases Expression [20]
Guanine nucleotide-binding protein subunit beta-5 (GNB5) OT3ZSAXH GNB5_HUMAN Increases Methylation [10]
Kinetochore protein NDC80 homolog (NDC80) OTS7D306 NDC80_HUMAN Decreases Expression [11]
Neuropilin-1 (NRP1) OTCGULYV NRP1_HUMAN Decreases Expression [12]
Ras-specific guanine nucleotide-releasing factor 2 (RASGRF2) OT67DAGF RGRF2_HUMAN Decreases Methylation [10]
Protocadherin-17 (PCDH17) OTRK0M05 PCD17_HUMAN Decreases Methylation [10]
Regulator of G-protein signaling 12 (RGS12) OTNCIQTH RGS12_HUMAN Increases Methylation [10]
Microtubule-associated serine/threonine-protein kinase 4 (MAST4) OT3LOE2J MAST4_HUMAN Increases Methylation [10]
Guanine nucleotide exchange factor DBS (MCF2L) OTEURA8N MCF2L_HUMAN Affects Methylation [10]
Ephrin type-B receptor 6 (EPHB6) OTKNN6GC EPHB6_HUMAN Increases Methylation [10]
Laminin subunit alpha-5 (LAMA5) OTIIXE4M LAMA5_HUMAN Increases Methylation [10]
Ataxin-7 (ATXN7) OTL3YF1H ATX7_HUMAN Decreases Methylation [10]
Tumor protein p73 (TP73) OT0LUO47 P73_HUMAN Increases Methylation [10]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [11]
Trinucleotide repeat-containing gene 18 protein (TNRC18) OTREUWWG TNC18_HUMAN Decreases Methylation [10]
Tapasin (TAPBP) OTL81AVZ TPSN_HUMAN Increases Methylation [10]
Rho guanine nucleotide exchange factor 9 (ARHGEF9) OTB1FLIW ARHG9_HUMAN Increases Methylation [10]
ERI1 exoribonuclease 3 (ERI3) OT0HIU61 ERI3_HUMAN Increases Methylation [10]
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) OTDTF5BU SUV91_HUMAN Increases Methylation [10]
Forkhead box protein O3 (FOXO3) OTHXQG4P FOXO3_HUMAN Affects Localization [21]
Protein sprouty homolog 2 (SPRY2) OTH0CRCZ SPY2_HUMAN Affects Methylation [10]
Pleiotropic regulator 1 (PLRG1) OTIVZ5LL PLRG1_HUMAN Increases Methylation [10]
Protein regulator of cytokinesis 1 (PRC1) OTHD0XS0 PRC1_HUMAN Decreases Expression [12]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) OT80DZMT BUB1_HUMAN Decreases Expression [11]
Sialic acid-binding Ig-like lectin 6 (SIGLEC6) OTO4F5C9 SIGL6_HUMAN Increases Methylation [10]
Tolloid-like protein 1 (TLL1) OTK9NM7G TLL1_HUMAN Decreases Methylation [10]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) OTJKOMXE BNI3L_HUMAN Increases Methylation [10]
NUAK family SNF1-like kinase 1 (NUAK1) OTLLHJJQ NUAK1_HUMAN Increases Methylation [10]
Phospholipid-transporting ATPase VA (ATP10A) OTYF5A7X AT10A_HUMAN Decreases Methylation [10]
Protein ENTREP2 (ENTREP2) OTEUHFKS EREP2_HUMAN Increases Methylation [10]
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1C) OT3LPG1R PI51C_HUMAN Decreases Methylation [10]
Gasdermin-E (GSDME) OT1ZWY32 GSDME_HUMAN Increases Methylation [10]
Docking protein 2 (DOK2) OTIJ38UF DOK2_HUMAN Increases Methylation [10]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) OT8KME51 BUB1B_HUMAN Decreases Expression [11]
Musculin (MSC) OTBRPZL5 MUSC_HUMAN Increases Methylation [10]
Catenin delta-1 (CTNND1) OTUMPSHR CTND1_HUMAN Decreases Methylation [10]
Low-density lipoprotein receptor-related protein 3 (LRP3) OTXMLT8C LRP3_HUMAN Increases Methylation [10]
Protein CBFA2T3 (CBFA2T3) OTOJ10S1 MTG16_HUMAN Increases Methylation [10]
Multiple epidermal growth factor-like domains protein 6 (MEGF6) OTEUYTP1 MEGF6_HUMAN Increases Methylation [10]
Rho-associated protein kinase 2 (ROCK2) OTVYN14T ROCK2_HUMAN Increases Methylation [10]
TSC22 domain family protein 2 (TSC22D2) OTFXF349 T22D2_HUMAN Increases Methylation [10]
Cadherin-16 (CDH16) OTR0GE9G CAD16_HUMAN Increases Methylation [10]
Nuclear receptor corepressor 1 (NCOR1) OT04XNOU NCOR1_HUMAN Increases Expression [12]
Alpha-tectorin (TECTA) OT5E0NE2 TECTA_HUMAN Decreases Methylation [10]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Activity [22]
PC4 and SFRS1-interacting protein (PSIP1) OT4YAFUS PSIP1_HUMAN Increases Methylation [10]
Carbonic anhydrase-related protein 11 (CA11) OT8RX3AJ CAH11_HUMAN Decreases Methylation [10]
Disabled homolog 1 (DAB1) OTPL9MA3 DAB1_HUMAN Increases Methylation [10]
Serpin B7 (SERPINB7) OTZ95LR2 SPB7_HUMAN Increases Methylation [10]
Cell cycle checkpoint protein RAD17 (RAD17) OT1I93DT RAD17_HUMAN Increases Methylation [10]
CCN family member 5 (CCN5) OTADU8JJ CCN5_HUMAN Increases Expression [12]
Regulator of G-protein signaling 20 (RGS20) OT6CGYHW RGS20_HUMAN Increases Methylation [10]
Serine/threonine-protein kinase 17B (STK17B) OT4NYNO8 ST17B_HUMAN Increases Methylation [10]
Slit homolog 2 protein (SLIT2) OTLS2RJ4 SLIT2_HUMAN Increases Methylation [10]
Dendrin (DDN) OTM52ZF5 DEND_HUMAN Increases Methylation [10]
Protein FAM13A (FAM13A) OTZ6GN0Q FA13A_HUMAN Decreases Methylation [10]
G2/mitotic-specific cyclin-B2 (CCNB2) OTIEXTDK CCNB2_HUMAN Decreases Expression [11]
Serine protease 23 (PRSS23) OT6DQAM1 PRS23_HUMAN Increases Methylation [10]
NADH dehydrogenase 1 beta subcomplex subunit 2, mitochondrial (NDUFB2) OT4717TF NDUB2_HUMAN Increases Methylation [10]
Potassium voltage-gated channel subfamily H member 1 (KCNH1) OTZZXWER KCNH1_HUMAN Decreases Expression [23]
NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10) OTBURQ3A NDUAA_HUMAN Decreases Methylation [10]
CUGBP Elav-like family member 2 (CELF2) OTLJJ4VT CELF2_HUMAN Increases Methylation [10]
Homeobox protein SIX3 (SIX3) OTP5E3VU SIX3_HUMAN Decreases Methylation [10]
Transforming acidic coiled-coil-containing protein 2 (TACC2) OTW4M7HI TACC2_HUMAN Increases Methylation [10]
Supervillin (SVIL) OTWQQ1WK SVIL_HUMAN Increases Methylation [10]
Sodium-dependent phosphate transport protein 2B (SLC34A2) OTLFMBB0 NPT2B_HUMAN Increases Methylation [10]
Adhesion G protein-coupled receptor L2 (ADGRL2) OTCXD2YR AGRL2_HUMAN Decreases Methylation [10]
Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10) OTL32QH7 GTR10_HUMAN Decreases Methylation [10]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Decreases Methylation [10]
Zinc finger protein SNAI1 (SNAI1) OTDPYAMC SNAI1_HUMAN Increases Expression [12]
Phosphatidylserine lipase ABHD16A (ABHD16A) OTDS9K1Z ABHGA_HUMAN Increases Methylation [10]
Uncharacterized protein C6orf47 (C6ORF47) OTMKBNDD CF047_HUMAN Increases Methylation [10]
One cut domain family member 2 (ONECUT2) OTHUE5YY ONEC2_HUMAN Increases Methylation [10]
Cholesterol 25-hydroxylase (CH25H) OT9S2BSW CH25H_HUMAN Increases Methylation [10]
Securin (PTTG1) OTIMYS4W PTTG1_HUMAN Decreases Expression [24]
G1/S-specific cyclin-E2 (CCNE2) OTBBUKQQ CCNE2_HUMAN Decreases Expression [11]
Aspartate aminotransferase, mitochondrial (GOT2) OT6XBWN0 AATM_HUMAN Increases Methylation [10]
Adenosine deaminase (ADA) OTOX2872 ADA_HUMAN Decreases Methylation [10]
Complement C3 (C3) OTCH5GS0 CO3_HUMAN Decreases Expression [12]
Pro-epidermal growth factor (EGF) OTANRJ0L EGF_HUMAN Affects Activity [25]
Protransforming growth factor alpha (TGFA) OTPD1LL9 TGFA_HUMAN Increases Expression [12]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Increases Expression [26]
Prolactin (PRL) OTWFQGX7 PRL_HUMAN Decreases Secretion [27]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [28]
Complement component C9 (C9) OT7I5FDX CO9_HUMAN Increases Methylation [10]
Lactotransferrin (LTF) OT8JWCZ0 TRFL_HUMAN Increases Expression [12]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Decreases Expression [29]
Glucocorticoid receptor (NR3C1) OTCI2YDI GCR_HUMAN Increases Expression [12]
Trefoil factor 1 (TFF1) OTCYQH4F TFF1_HUMAN Decreases Expression [30]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Decreases Expression [31]
Non-histone chromosomal protein HMG-14 (HMGN1) OTSMGH99 HMGN1_HUMAN Decreases Methylation [10]
Plasminogen activator inhibitor 2 (SERPINB2) OT72QLZB PAI2_HUMAN Increases Expression [28]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Expression [28]
Keratin, type I cytoskeletal 18 (KRT18) OTVLQFIP K1C18_HUMAN Increases Methylation [10]
Tyrosine-protein kinase Lck (LCK) OT883FG9 LCK_HUMAN Increases Methylation [10]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Phosphorylation [32]
Progesterone receptor (PGR) OT0FZ3QE PRGR_HUMAN Decreases Expression [33]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [11]
ATP synthase subunit beta, mitochondrial (ATP5F1B) OTLFZUQK ATPB_HUMAN Increases Expression [34]
Complement C2 (C2) OTHMF4YM CO2_HUMAN Increases Methylation [10]
Lipoprotein lipase (LPL) OTTW0267 LIPL_HUMAN Decreases Expression [12]
Neurofilament medium polypeptide (NEFM) OT8VCBNF NFM_HUMAN Increases Methylation [10]
Thyroid peroxidase (TPO) OTJJLL20 PERT_HUMAN Increases Methylation [10]
Prostate-specific antigen (KLK3) OTFGSBFJ KLK3_HUMAN Decreases Expression [12]
Cathepsin D (CTSD) OTQZ36F3 CATD_HUMAN Decreases Expression [30]
Heat shock protein HSP 90-alpha (HSP90AA1) OTLG1WPK HS90A_HUMAN Increases Expression [12]
Tyrosine-protein kinase Lyn (LYN) OTP686K2 LYN_HUMAN Increases Methylation [10]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Increases Expression [12]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Increases Phosphorylation [35]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [36]
Insulin-like growth factor-binding protein 1 (IGFBP1) OT6UQV2K IBP1_HUMAN Increases Expression [12]
Galectin-1 (LGALS1) OT8LDFWR LEG1_HUMAN Increases Expression [12]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Decreases Expression [28]
Granulocyte colony-stimulating factor (CSF3) OT9GC6TP CSF3_HUMAN Decreases Expression [28]
Histone H2A.Z (H2AZ1) OT3KJJNQ H2AZ_HUMAN Decreases Expression [37]
Protein RD3-like (RD3L) OTLV3BU0 RD3L_HUMAN Increases Methylation [10]
Granzyme B (GZMB) OTPPVIRS GRAB_HUMAN Decreases Expression [26]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [28]
Lysosomal alpha-glucosidase (GAA) OT03PU29 LYAG_HUMAN Increases Methylation [10]
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Decreases Expression [33]
Retinoic acid receptor alpha (RARA) OT192V9V RARA_HUMAN Decreases Expression [12]
Osteopontin (SPP1) OTJGC23Y OSTP_HUMAN Increases Expression [12]
Nuclear receptor subfamily 2 group F member 6 (NR2F6) OTNVO2B6 NR2F6_HUMAN Increases Expression [12]
Transforming growth factor beta-3 proprotein (TGFB3) OT2LOUQ1 TGFB3_HUMAN Decreases Expression [12]
Microtubule-associated protein tau (MAPT) OTMTP2Z7 TAU_HUMAN Decreases Expression [38]
Mast/stem cell growth factor receptor Kit (KIT) OTHUY3VZ KIT_HUMAN Increases Methylation [10]
Ras-related protein Ral-A (RALA) OT734R7X RALA_HUMAN Increases Expression [12]
Spectrin beta chain, erythrocytic (SPTB) OT1Q9ABM SPTB1_HUMAN Increases Methylation [10]
Serine/threonine-protein kinase pim-1 (PIM1) OTWEKXTU PIM1_HUMAN Increases Expression [28]
Glucose-6-phosphate 1-dehydrogenase (G6PD) OT300SMK G6PD_HUMAN Increases Expression [12]
Steroid hormone receptor ERR1 (ESRRA) OTTDTUSP ERR1_HUMAN Increases Expression [34]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Increases Expression [12]
Dystrophin (DMD) OTD21T5J DMD_HUMAN Decreases Methylation [10]
Collagen alpha-2(VI) chain (COL6A2) OTQC6PPO CO6A2_HUMAN Increases Methylation [10]
Creatine kinase B-type (CKB) OTUCKOTT KCRB_HUMAN Increases Expression [12]
Bone morphogenetic protein 4 (BMP4) OTPZMDFH BMP4_HUMAN Increases Expression [12]
Nuclear receptor subfamily 2 group C member 1 (NR2C1) OTJEL7WT NR2C1_HUMAN Increases Methylation [10]
Gamma-interferon-inducible lysosomal thiol reductase (IFI30) OT9DERT1 GILT_HUMAN Decreases Methylation [10]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Increases Expression [12]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1) OTNAZVKB 3BHS1_HUMAN Increases Methylation [10]
Perforin-1 (PRF1) OTFVXD7H PERF_HUMAN Decreases Expression [26]
Interleukin-1 receptor type 1 (IL1R1) OTTU8959 IL1R1_HUMAN Increases Methylation [10]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Increases Expression [12]
Junction plakoglobin (JUP) OTUH7VMO PLAK_HUMAN Increases Methylation [10]
Nucleoside diphosphate kinase A (NME1) OT0NELQ1 NDKA_HUMAN Decreases Expression [11]
Transcription factor 4 (TCF4) OTB9ASTK ITF2_HUMAN Increases Methylation [10]
Platelet-derived growth factor receptor alpha (PDGFRA) OTDJXUCN PGFRA_HUMAN Decreases Methylation [10]
Carboxypeptidase E (CPE) OTXNTV79 CBPE_HUMAN Increases Methylation [10]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Increases Expression [12]
Gap junction alpha-1 protein (GJA1) OTT94MKL CXA1_HUMAN Decreases Expression [39]
Creatine kinase S-type, mitochondrial (CKMT2) OT1KNPI1 KCRS_HUMAN Increases Methylation [10]
Insulin-like growth factor-binding protein 3 (IGFBP3) OTIX63TX IBP3_HUMAN Increases Methylation [10]
Bone morphogenetic protein 7 (BMP7) OTYATP2K BMP7_HUMAN Increases Expression [12]
Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) OTSXJGQF ITIH1_HUMAN Increases Methylation [10]
C-X-C motif chemokine 3 (CXCL3) OTSL94KH CXCL3_HUMAN Increases Expression [28]
Follistatin (FST) OTRIVK9Y FST_HUMAN Increases Expression [28]
Gastricsin (PGC) OTQRITKI PEPC_HUMAN Increases Methylation [10]
B-cell receptor CD22 (CD22) OTXDJR9T CD22_HUMAN Increases Methylation [10]
T-cell surface glycoprotein CD3 zeta chain (CD247) OT45FGUX CD3Z_HUMAN Increases Methylation [10]
Cytoplasmic aconitate hydratase (ACO1) OT2VUR7L ACOHC_HUMAN Increases Methylation [10]
Receptor tyrosine-protein kinase erbB-3 (ERBB3) OTRSST0A ERBB3_HUMAN Decreases Expression [12]
Catechol O-methyltransferase (COMT) OTPWKTQG COMT_HUMAN Increases Expression [12]
Tenascin-X (TNXB) OTVBWAV5 TENX_HUMAN Increases Methylation [10]
Fibulin-1 (FBLN1) OT5MHHOP FBLN1_HUMAN Increases Methylation [10]
Transcription elongation factor A protein 1 (TCEA1) OTBFO594 TCEA1_HUMAN Decreases Methylation [10]
Cerebellin-1 (CBLN1) OTIXFRAG CBLN1_HUMAN Increases Methylation [10]
Brain-derived neurotrophic factor (BDNF) OTLGH7EW BDNF_HUMAN Increases Expression [12]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [29]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Increases Expression [12]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Decreases Expression [40]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Increases Expression [40]
Endothelin-1 receptor (EDNRA) OTK9T5O3 EDNRA_HUMAN Increases Methylation [10]
Atypical chemokine receptor 3 (ACKR3) OTA6GA4F ACKR3_HUMAN Decreases Methylation [10]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Decreases Expression [28]
Integrin beta-7 (ITGB7) OT33UUKU ITB7_HUMAN Increases Methylation [10]
DNA cytosine-5)-methyltransferase 1 (DNMT1) OTM2DGTK DNMT1_HUMAN Decreases Expression [11]
NKG2-C type II integral membrane protein (KLRC2) OTT4N86S NKG2C_HUMAN Increases Methylation [10]
Beta-crystallin B3 (CRYBB3) OTTGTQIQ CRBB3_HUMAN Decreases Methylation [10]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Increases Phosphorylation [41]
Proteasome subunit beta type-8 (PSMB8) OTW5XGMF PSB8_HUMAN Increases Methylation [10]
Choline O-acetyltransferase (CHAT) OTEJWQ45 CLAT_HUMAN Increases Methylation [10]
Gamma-aminobutyric acid receptor subunit rho-2 (GABRR2) OTLDLU1S GBRR2_HUMAN Increases Methylation [10]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Phosphorylation [41]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Increases Expression [12]
Lysine-specific demethylase 5A (KDM5A) OTLYFX8A KDM5A_HUMAN Increases Methylation [10]
Leukocyte tyrosine kinase receptor (LTK) OT4GPX7K LTK_HUMAN Decreases Methylation [10]
Transmembrane 4 L6 family member 1 (TM4SF1) OTY0ECQN T4S1_HUMAN Increases Methylation [10]
Adenosine receptor A1 (ADORA1) OTI7X39E AA1R_HUMAN Decreases Expression [12]
Fibroblast growth factor 9 (FGF9) OT2SKDGM FGF9_HUMAN Decreases Expression [42]
Sodium- and chloride-dependent taurine transporter (SLC6A6) OT67U7G3 SC6A6_HUMAN Increases Methylation [10]
Gamma-aminobutyric acid receptor subunit alpha-5 (GABRA5) OTBIKWQT GBRA5_HUMAN Decreases Methylation [10]
DnaJ homolog subfamily A member 1 (DNAJA1) OT38BZQQ DNJA1_HUMAN Increases Methylation [10]
3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) OTCMMMIZ 3HIDH_HUMAN Increases Methylation [10]
Neural cell adhesion molecule L1 (L1CAM) OTNWAQ4Y L1CAM_HUMAN Increases Expression [12]
CD70 antigen (CD70) OTHB2AL1 CD70_HUMAN Increases Methylation [10]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1) OTB06ESI ACSL1_HUMAN Increases Methylation [10]
Cytochrome P450 2C18 (CYP2C18) OTY687L9 CP2CI_HUMAN Increases Methylation [10]
Protein S100-A5 (S100A5) OTCGGL6K S10A5_HUMAN Increases Expression [12]
Protein S100-A3 (S100A3) OTVIZJ2R S10A3_HUMAN Increases Methylation [10]
Dual specificity protein kinase TTK (TTK) OTBY1Z5H TTK_HUMAN Decreases Expression [11]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Increases Expression [12]
Nuclear receptor ROR-alpha (RORA) OTGQT12P RORA_HUMAN Increases Methylation [10]
Sodium channel protein type 1 subunit alpha (SCN1A) OTJ9ZTYI SCN1A_HUMAN Increases Methylation [10]
Hepatocyte nuclear factor 1-beta (HNF1B) OTSYIC3T HNF1B_HUMAN Decreases Expression [43]
Transcription factor SOX-6 (SOX6) OTT0W0LE SOX6_HUMAN Increases Methylation [10]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Increases Expression [12]
Receptor-type tyrosine-protein kinase FLT3 (FLT3) OTMSRYMK FLT3_HUMAN Increases Methylation [10]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [29]
Collagen alpha-1(XVIII) chain (COL18A1) OTJFUH6O COIA1_HUMAN Increases Methylation [10]
Pre-B-cell leukemia transcription factor 3 (PBX3) OT8WMVM4 PBX3_HUMAN Increases Methylation [10]
Glutamate receptor 3 (GRIA3) OT34CNBR GRIA3_HUMAN Decreases Methylation [10]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB) OTO8JQJA PK3CB_HUMAN Increases Methylation [10]
Phosphatidylinositol 4-kinase alpha (PI4KA) OT2L2G6C PI4KA_HUMAN Increases Methylation [10]
Dipeptidyl aminopeptidase-like protein 6 (DPP6) OTWW3H0K DPP6_HUMAN Decreases Methylation [10]
Tyrosine-protein kinase Tec (TEC) OTU6QJAJ TEC_HUMAN Increases Methylation [10]
Condensin-2 complex subunit D3 (NCAPD3) OTOZY2UL CNDD3_HUMAN Increases Methylation [10]
Cathepsin O (CTSO) OTFL6VRO CATO_HUMAN Increases Expression [12]
Aldehyde dehydrogenase family 3 member B1 (ALDH3B1) OT5NEUQE AL3B1_HUMAN Increases Methylation [10]
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4) OTDK74C0 TNR4_HUMAN Decreases Methylation [10]
Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4) OT1H0ZXC ACHA4_HUMAN Increases Methylation [10]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [32]
5-hydroxytryptamine receptor 5A (HTR5A) OTRKPCQV 5HT5A_HUMAN Increases Methylation [10]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Decreases Methylation [10]
G protein-activated inward rectifier potassium channel 2 (KCNJ6) OTDE1FT0 KCNJ6_HUMAN Increases Methylation [10]
Retinoic acid receptor RXR-gamma (RXRG) OT254B09 RXRG_HUMAN Decreases Methylation [10]
Nuclear receptor-interacting protein 1 (NRIP1) OTIZOJQV NRIP1_HUMAN Decreases Expression [12]
Protein PRRC2A (PRRC2A) OTBX6FM5 PRC2A_HUMAN Increases Methylation [10]
Protein farnesyltransferase subunit beta (CHURC1-FNTB) OT34M7E3 FNTB_HUMAN Increases Methylation [10]
Protein phosphatase 1F (PPM1F) OTU0MVR7 PPM1F_HUMAN Increases Methylation [10]
Casein kinase I isoform epsilon (CSNK1E) OTF0UXX6 KC1E_HUMAN Increases Methylation [10]
CCAAT/enhancer-binding protein delta (CEBPD) OTNBIPMY CEBPD_HUMAN Increases Methylation [10]
Nuclear pore complex protein Nup153 (NUP153) OTCAS0AR NU153_HUMAN Increases Methylation [10]
Protein Tob1 (TOB1) OTNW949D TOB1_HUMAN Increases Methylation [10]
Lipopolysaccharide-responsive and beige-like anchor protein (LRBA) OTOUZN9G LRBA_HUMAN Increases Methylation [10]
Transcription activator BRG1 (SMARCA4) OT68WOPQ SMCA4_HUMAN Decreases Expression [31]
Nuclear receptor subfamily 0 group B member 1 (NR0B1) OTC8P9GN NR0B1_HUMAN Increases Expression [12]
Serine/threonine-protein kinase Nek2 (NEK2) OT1H27HO NEK2_HUMAN Decreases Expression [11]
Beta-chimaerin (CHN2) OTSSDPWN CHIO_HUMAN Increases Methylation [10]
Ephrin-A5 (EFNA5) OTOH4DRR EFNA5_HUMAN Increases Expression [12]
Stanniocalcin-1 (STC1) OTGVVXYF STC1_HUMAN Decreases Methylation [10]
Ataxin-1 (ATXN1) OTQF0HNR ATX1_HUMAN Increases Methylation [10]
Huntingtin-associated protein 1 (HAP1) OT6SG0JQ HAP1_HUMAN Increases Methylation [10]
Myomesin-2 (MYOM2) OTD2UOXW MYOM2_HUMAN Increases Methylation [10]
Tyrosine-protein phosphatase non-receptor type 5 (PTPN5) OT2H1KDK PTN5_HUMAN Increases Methylation [10]
Protein AF-10 (MLLT10) OTURMDV7 AF10_HUMAN Increases Methylation [10]
Adenosine kinase (ADK) OTXR6VDI ADK_HUMAN Increases Methylation [10]
Hepatocyte nuclear factor 3-alpha (FOXA1) OTEBY0TD FOXA1_HUMAN Increases Expression [12]
Galectin-4 (LGALS4) OTKQCG0H LEG4_HUMAN Increases Methylation [10]
Histone deacetylase 4 (HDAC4) OTQNGD32 HDAC4_HUMAN Increases Methylation [10]
Claudin-17 (CLDN17) OTQCEYBY CLD17_HUMAN Decreases Methylation [10]
Breast cancer anti-estrogen resistance protein 1 (BCAR1) OTKT2C2N BCAR1_HUMAN Increases Expression [12]
Pro-neuregulin-3, membrane-bound isoform (NRG3) OTIFZ5CT NRG3_HUMAN Increases Methylation [10]
Claudin-2 (CLDN2) OTRF3D6Y CLD2_HUMAN Decreases Methylation [10]
Neurexin-1-beta (NRXN1) OTJN1JQA NRX1B_HUMAN Decreases Methylation [10]
CD81 antigen (CD81) OTQFXNAZ CD81_HUMAN Increases Methylation [10]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Increases Methylation [10]
26S proteasome complex subunit SEM1 (SEM1) OTASLBM1 SEM1_HUMAN Decreases Methylation [10]
Protein max (MAX) OTKZ0YKM MAX_HUMAN Increases Methylation [10]
Small ribosomal subunit protein eS7 (RPS7) OTIK25WI RS7_HUMAN Increases Methylation [10]
Small nuclear ribonucleoprotein G (SNRPG) OTWX4XK1 RUXG_HUMAN Increases Methylation [10]
DNA-directed RNA polymerases I, II, and III subunit RPABC5 (POLR2L) OTSSOMUP RPAB5_HUMAN Decreases Methylation [10]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A) OT9297OG 2ABA_HUMAN Increases Methylation [10]
Inward rectifier potassium channel 2 (KCNJ2) OT2OQEZS KCNJ2_HUMAN Decreases Methylation [10]
Tropomyosin alpha-4 chain (TPM4) OTN4YLYR TPM4_HUMAN Increases Methylation [10]
Actin, alpha skeletal muscle (ACTA1) OTOVGLPG ACTS_HUMAN Increases Methylation [10]
Reelin (RELN) OTLKMW1O RELN_HUMAN Increases Methylation [10]
C-C motif chemokine 20 (CCL20) OTUCJY4N CCL20_HUMAN Increases Expression [28]
Small ribosomal subunit protein uS9m (MRPS9) OTD4XOHS RT09_HUMAN Decreases Methylation [10]
Mothers against decapentaplegic homolog 3 (SMAD3) OTNA96MR SMAD3_HUMAN Increases Methylation [10]
Calcium-transporting ATPase type 2C member 1 (ATP2C1) OTQN51T3 AT2C1_HUMAN Affects Methylation [10]
Phospholipid-transporting ATPase IH (ATP11A) OT7M9ZDK AT11A_HUMAN Increases Methylation [10]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Increases Expression [34]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Increases Expression [31]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Decreases Expression [40]
Runt-related transcription factor 1 (RUNX1) OTU7J84H RUNX1_HUMAN Decreases Methylation [10]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Increases Methylation [10]
ATP-dependent 6-phosphofructokinase, platelet type (PFKP) OTFP7AA8 PFKAP_HUMAN Increases Methylation [10]
DNA-binding protein SATB1 (SATB1) OTT7SUVW SATB1_HUMAN Decreases Methylation [10]
Zinc finger protein basonuclin-1 (BNC1) OTGJ5WUF BNC1_HUMAN Decreases Methylation [10]
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) OTEUYEW6 ROR1_HUMAN Increases Methylation [10]
2-oxoglutarate dehydrogenase complex component E1 (OGDH) OTHGTQWF ODO1_HUMAN Increases Methylation [10]
Pro-neuregulin-1, membrane-bound isoform (NRG1) OTZO6F1X NRG1_HUMAN Increases Methylation [10]
Dystonin (DST) OTHZBM4X DYST_HUMAN Increases Methylation [10]
Caveolin-1 (CAV1) OTEZUR1L CAV1_HUMAN Decreases Expression [12]
Trefoil factor 2 (TFF2) OTRXB19X TFF2_HUMAN Decreases Expression [44]
Early growth response protein 4 (EGR4) OT4R3ECK EGR4_HUMAN Increases Methylation [10]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Increases Degradation [41]
Homeobox protein engrailed-1 (EN1) OT2DKIDK HME1_HUMAN Decreases Methylation [10]
Recombining binding protein suppressor of hairless (RBPJ) OTD7CUG0 SUH_HUMAN Increases Methylation [10]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Decreases Expression [11]
Collagen alpha-1(XVI) chain (COL16A1) OTOWKUO2 COGA1_HUMAN Increases Methylation [10]
Trichohyalin (TCHH) OT4J7EFT TRHY_HUMAN Decreases Methylation [10]
Forkhead box protein M1 (FOXM1) OT5887KR FOXM1_HUMAN Decreases Expression [11]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D) OT1RWFV0 PDE4D_HUMAN Decreases Methylation [10]
Transmembrane protein 62 (TMEM62) OTJ4SPCM TMM62_HUMAN Increases Methylation [10]
General transcription factor 3C polypeptide 1 (GTF3C1) OT7JK0RG TF3C1_HUMAN Increases Methylation [10]
Calcium-activated potassium channel subunit alpha-1 (KCNMA1) OTNYXOZO KCMA1_HUMAN Increases Methylation [10]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) OT2LP7LJ SNF5_HUMAN Increases Expression [31]
Cell division cycle protein 20 homolog (CDC20) OTCOEZRV CDC20_HUMAN Decreases Expression [11]
Follistatin-related protein 1 (FSTL1) OT6KEZUD FSTL1_HUMAN Increases Methylation [10]
Splicing factor, suppressor of white-apricot homolog (SFSWAP) OT7H3ETA SFSWA_HUMAN Increases Methylation [10]
Heat shock protein 75 kDa, mitochondrial (TRAP1) OTNG0L8J TRAP1_HUMAN Increases Methylation [10]
Ankyrin-3 (ANK3) OTJ3IRBP ANK3_HUMAN Increases Methylation [10]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2) OTVZD4H6 BNIP2_HUMAN Increases Methylation [10]
Interleukin-24 (IL24) OT4VUWH1 IL24_HUMAN Increases Expression [28]
Semaphorin-3B (SEMA3B) OTCZCPMS SEM3B_HUMAN Increases Methylation [10]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) OTXNGZCG MD2L1_HUMAN Decreases Expression [11]
Growth factor receptor-bound protein 10 (GRB10) OTCKXGRC GRB10_HUMAN Increases Methylation [10]
Metastasis-associated protein MTA1 (MTA1) OTBHW3S9 MTA1_HUMAN Decreases Expression [12]
C-terminal-binding protein 1 (CTBP1) OTVYH2DH CTBP1_HUMAN Decreases Expression [12]
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9) OT70Z4II ADAM9_HUMAN Increases Methylation [10]
snRNA-activating protein complex subunit 2 (SNAPC2) OTN0EL6L SNPC2_HUMAN Increases Methylation [10]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Increases Methylation [10]
Phosphatidylinositol-binding clathrin assembly protein (PICALM) OTQVRPMQ PICAL_HUMAN Increases Methylation [10]
Mastermind-like domain-containing protein 1 (MAMLD1) OT9EVMQY MAMD1_HUMAN Decreases Methylation [10]
Solute carrier family 12 member 1 (SLC12A1) OT6YSX0G S12A1_HUMAN Decreases Methylation [10]
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) OTPLXCDN DYR1A_HUMAN Decreases Methylation [10]
Protein patched homolog 1 (PTCH1) OTMG07H5 PTC1_HUMAN Increases Expression [12]
Nuclear receptor coactivator 4 (NCOA4) OTRVU0UA NCOA4_HUMAN Increases Methylation [10]
ADP-ribosylation factor-related protein 1 (ARFRP1) OTP1OV78 ARFRP_HUMAN Increases Methylation [10]
Protein Shroom2 (SHROOM2) OTZ2FJ7Q SHRM2_HUMAN Increases Methylation [10]
Beta-1-syntrophin (SNTB1) OTSRBECI SNTB1_HUMAN Decreases Methylation [10]
Nuclear nucleic acid-binding protein C1D (C1D) OTI9PMN1 C1D_HUMAN Decreases Methylation [10]
Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) OT6KFNMS CAC1C_HUMAN Increases Methylation [10]
Nidogen-2 (NID2) OTHC33FF NID2_HUMAN Increases Methylation [10]
Protein FAM53B (FAM53B) OTVD7OU6 FA53B_HUMAN Decreases Methylation [10]
Four and a half LIM domains protein 2 (FHL2) OT0OAYWT FHL2_HUMAN Increases Methylation [10]
Dihydropyrimidinase-related protein 3 (DPYSL3) OTINJV20 DPYL3_HUMAN Increases Methylation [10]
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) OTD1KRKO DYHC1_HUMAN Increases Methylation [10]
Elongin-A (ELOA) OTOQTF5K ELOA1_HUMAN Increases Methylation [10]
Filamin-C (FLNC) OT3F8J6Y FLNC_HUMAN Decreases Methylation [10]
Histone RNA hairpin-binding protein (SLBP) OTVYYQRT SLBP_HUMAN Decreases Methylation [10]
Inositol 1,4,5-trisphosphate receptor type 2 (ITPR2) OTPHGZ19 ITPR2_HUMAN Increases Methylation [10]
Indian hedgehog protein (IHH) OT1DWGXC IHH_HUMAN Decreases Methylation [10]
Separin (ESPL1) OTMGEVOK ESPL1_HUMAN Decreases Expression [11]
Disco-interacting protein 2 homolog A (DIP2A) OTXPTR8R DIP2A_HUMAN Decreases Methylation [10]
Latent-transforming growth factor beta-binding protein 1 (LTBP1) OTR7Q75L LTBP1_HUMAN Decreases Expression [12]
LIM and SH3 domain protein 1 (LASP1) OT2QIDCL LASP1_HUMAN Increases Methylation [10]
Sodium/hydrogen exchanger 5 (SLC9A5) OTM70CXN SL9A5_HUMAN Decreases Methylation [10]
Protein disulfide-isomerase A6 (PDIA6) OT8YBR17 PDIA6_HUMAN Increases Methylation [10]
Inactive phospholipase C-like protein 1 (PLCL1) OTJL2C79 PLCL1_HUMAN Decreases Methylation [10]
Cyclin-dependent kinase 10 (CDK10) OTKP7TTR CDK10_HUMAN Increases Methylation [10]
Plectin (PLEC) OTU4XDEG PLEC_HUMAN Increases Methylation [10]
Serine/threonine-protein kinase 38 (STK38) OTKMYCYR STK38_HUMAN Increases Methylation [10]
RalA-binding protein 1 (RALBP1) OTBIGB1D RBP1_HUMAN Increases Methylation [10]
Ribosomal protein S6 kinase alpha-2 (RPS6KA2) OTIOYUSU KS6A2_HUMAN Decreases Methylation [10]
Scaffold attachment factor B1 (SAFB) OTGRV2LW SAFB1_HUMAN Increases Methylation [10]
Nuclear receptor subfamily 0 group B member 2 (NR0B2) OT7UVICX NR0B2_HUMAN Decreases Expression [12]
Nuclear receptor coactivator 2 (NCOA2) OTMQFPBB NCOA2_HUMAN Increases Expression [12]
Olfactory receptor 1C1 (OR1C1) OT9WTEX5 OR1C1_HUMAN Decreases Methylation [10]
Mediator of RNA polymerase II transcription subunit 1 (MED1) OTOO24C4 MED1_HUMAN Decreases Expression [12]
ETS-related transcription factor Elf-2 (ELF2) OTEI347F ELF2_HUMAN Increases Methylation [10]
NGFI-A-binding protein 2 (NAB2) OTG4BDF3 NAB2_HUMAN Increases Expression [12]
Nuclear receptor coactivator 1 (NCOA1) OTLIUJQD NCOA1_HUMAN Increases Expression [12]
Glutamate receptor ionotropic, kainate 4 (GRIK4) OTL5EIPA GRIK4_HUMAN Decreases Methylation [10]
NT-3 growth factor receptor (NTRK3) OTII30MY NTRK3_HUMAN Increases Methylation [10]
Meprin A subunit alpha (MEP1A) OTY2Z48T MEP1A_HUMAN Increases Methylation [10]
Receptor-type tyrosine-protein phosphatase O (PTPRO) OTFLKWOY PTPRO_HUMAN Increases Methylation [10]
Cysteine dioxygenase type 1 (CDO1) OTLG1P77 CDO1_HUMAN Decreases Methylation [10]
Protein inscuteable homolog (INSC) OTP16ERR INSC_HUMAN Increases Methylation [10]
Inverted formin-2 (INF2) OT8ZM13C INF2_HUMAN Increases Methylation [10]
Transmembrane protein 266 (TMEM266) OTM17VHD TM266_HUMAN Increases Methylation [10]
ATP-binding cassette sub-family B member 5 (ABCB5) OT8AKP1J ABCB5_HUMAN Increases Methylation [10]
CST complex subunit CTC1 (CTC1) OTRJY7QD CTC1_HUMAN Decreases Methylation [10]
FH1/FH2 domain-containing protein 3 (FHOD3) OT1WUBQX FHOD3_HUMAN Decreases Methylation [10]
Carcinoembryonic antigen-related cell adhesion molecule 16 (CEACAM16) OTUMUSY0 CEA16_HUMAN Increases Methylation [10]
Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) OTN7XAUD LRRF1_HUMAN Decreases Methylation [10]
Polycomb group RING finger protein 3 (PCGF3) OTY7TPPZ PCGF3_HUMAN Increases Methylation [10]
MAP7 domain-containing protein 1 (MAP7D1) OTMGC8N9 MA7D1_HUMAN Decreases Methylation [10]
Mucin-like protein 3 (MUCL3) OTGAD3I0 MUCL3_HUMAN Increases Methylation [10]
Cilia- and flagella-associated protein 100 (CFAP100) OTHHFM2Z CP100_HUMAN Increases Methylation [10]
Spermatogenesis-associated serine-rich protein 1 (SPATS1) OTPUXCSA SPAS1_HUMAN Decreases Methylation [10]
Cryptochrome-2 (CRY2) OTERZ93T CRY2_HUMAN Increases Methylation [10]
Ceramide kinase-like protein (CERKL) OTG4YGBR CERKL_HUMAN Decreases Methylation [10]
NAD kinase 2, mitochondrial (NADK2) OT1I8GDE NAKD2_HUMAN Decreases Methylation [10]
Glucoside xylosyltransferase 1 (GXYLT1) OTI5MDYW GXLT1_HUMAN Increases Methylation [10]
Protein GREB1 (GREB1) OTU6ZA26 GREB1_HUMAN Decreases Expression [12]
PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (PAN2) OTB65N2I PAN2_HUMAN Increases Methylation [10]
Acylglycerol kinase, mitochondrial (AGK) OTJGWBYT AGK_HUMAN Increases Methylation [10]
Fibulin-7 (FBLN7) OT1XRDP6 FBLN7_HUMAN Increases Methylation [10]
FRAS1-related extracellular matrix protein 1 (FREM1) OTMHRV87 FREM1_HUMAN Increases Methylation [10]
SH3 domain-containing protein 19 (SH3D19) OTVU3VS2 SH319_HUMAN Increases Methylation [10]
Protein crumbs homolog 2 (CRB2) OTG0L2CE CRUM2_HUMAN Increases Expression [12]
NHL repeat-containing protein 3 (NHLRC3) OTBI6YSN NHLC3_HUMAN Increases Methylation [10]
Dedicator of cytokinesis protein 11 (DOCK11) OTFSTN6A DOC11_HUMAN Increases Methylation [10]
Protein FAM78A (FAM78A) OTDZ36V8 FA78A_HUMAN Decreases Methylation [10]
EF-hand domain-containing protein 1 (EFHC1) OTS9IBNE EFHC1_HUMAN Increases Methylation [10]
Calcium homeostasis modulator protein 4 (CALHM4) OTUDL2HG CAHM4_HUMAN Increases Methylation [10]
Tubulin-specific chaperone cofactor E-like protein (TBCEL) OT2PZLLL TBCEL_HUMAN Increases Methylation [10]
Mucin-21 (MUC21) OTQ8GP5L MUC21_HUMAN Increases Methylation [10]
Uncharacterized protein C6orf132 (C6ORF132) OTMH4S7O CF132_HUMAN Increases Methylation [10]
Calmodulin-regulated spectrin-associated protein 1 (CAMSAP1) OT1N2182 CAMP1_HUMAN Increases Methylation [10]
Uncharacterized protein C1orf185 (C1ORF185) OT32C5NW CA185_HUMAN Increases Methylation [10]
Coiled-coil domain-containing protein 18 (CCDC18) OT0S9DA2 CCD18_HUMAN Decreases Methylation [10]
Growth hormone-regulated TBC protein 1 (GRTP1) OT8HORRZ GRTP1_HUMAN Increases Methylation [10]
Protein sel-1 homolog 2 (SEL1L2) OTSBDWIG SE1L2_HUMAN Increases Methylation [10]
E3 ubiquitin-protein ligase RNF220 (RNF220) OT2FIEXO RN220_HUMAN Increases Methylation [10]
Forkhead box protein B2 (FOXB2) OTJE3RRR FOXB2_HUMAN Increases Methylation [10]
Armadillo repeat-containing protein 3 (ARMC3) OTF6M9MM ARMC3_HUMAN Increases Methylation [10]
Anoctamin-1 (ANO1) OTSREUNI ANO1_HUMAN Increases Methylation [10]
Meteorin-like protein (METRNL) OTB0DDL0 METRL_HUMAN Increases Methylation [10]
DDB1- and CUL4-associated factor 15 (DCAF15) OTWBXZ0E DCA15_HUMAN Increases Methylation [10]
Autophagy-related protein 16-1 (ATG16L1) OTEOYC5D A16L1_HUMAN Increases Methylation [10]
Tensin-3 (TNS3) OTPG2D8Z TENS3_HUMAN Increases Methylation [10]
Coiled-coil domain-containing protein 102B (CCDC102B) OTVDZVD0 C102B_HUMAN Decreases Methylation [10]
Cytosolic phospholipase A2 zeta (PLA2G4F) OT8MUO5U PA24F_HUMAN Increases Methylation [10]
NADH-cytochrome b5 reductase 2 (CYB5R2) OTTLM7XN NB5R2_HUMAN Increases Methylation [10]
Bridge-like lipid transfer protein family member 3A (BLTP3A) OTRLMP17 BLT3A_HUMAN Increases Methylation [10]
Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2) OTV5S1J2 CARL2_HUMAN Increases Methylation [10]
Fatty-acid amide hydrolase 2 (FAAH2) OTS6LX01 FAAH2_HUMAN Decreases Methylation [10]
GRAM domain-containing protein 4 (GRAMD4) OT1HXEPM GRAM4_HUMAN Decreases Methylation [10]
Pleckstrin homology domain-containing family A member 7 (PLEKHA7) OTNUMAZ0 PKHA7_HUMAN Increases Methylation [10]
Beta-1,4-N-acetylgalactosaminyltransferase 3 (B4GALNT3) OT6BFB22 B4GN3_HUMAN Decreases Methylation [10]
Teneurin-4 (TENM4) OT91K3FC TEN4_HUMAN Increases Methylation [10]
SANT and BTB domain regulator of class switch recombination (SANBR) OTY7ZODH SANBR_HUMAN Decreases Methylation [10]
Homeobox-containing protein 1 (HMBOX1) OTPKTBVI HMBX1_HUMAN Increases Methylation [10]
TELO2-interacting protein 2 (TTI2) OTU7TQCO TTI2_HUMAN Decreases Methylation [10]
Phostensin (PPP1R18) OT0JVGOZ PPR18_HUMAN Decreases Methylation [10]
Phospholipase B1, membrane-associated (PLB1) OTZ6TTYV PLB1_HUMAN Increases Methylation [10]
Enhancer of mRNA-decapping protein 4 (EDC4) OTBBNIUJ EDC4_HUMAN Increases Methylation [10]
Uncharacterized protein C16orf46 (C16ORF46) OT8FDG3A CP046_HUMAN Increases Methylation [10]
Serine/threonine-protein kinase Nek5 (NEK5) OTHDXCYZ NEK5_HUMAN Increases Methylation [10]
Neuroblastoma breakpoint family member 10 (NBPF10) OTGOCELY NBPFA_HUMAN Affects Methylation [10]
NIPA-like protein 3 (NIPAL3) OTI858LL NPAL3_HUMAN Increases Methylation [10]
Cytochrome b5 domain-containing protein 1 (CYB5D1) OTSZWTPT CB5D1_HUMAN Increases Methylation [10]
E3 ubiquitin-protein ligase RFWD3 (RFWD3) OTDUULBQ RFWD3_HUMAN Decreases Methylation [10]
tRNA methyltransferase 10 homolog B (TRMT10B) OT3EJP6J TM10B_HUMAN Increases Methylation [10]
Kv channel-interacting protein 4 (KCNIP4) OTB1BS0X KCIP4_HUMAN Decreases Methylation [10]
Docking protein 6 (DOK6) OTX55OIF DOK6_HUMAN Affects Methylation [10]
Solute carrier family 25 member 47 (SLC25A47) OT5NGRWC S2547_HUMAN Increases Methylation [10]
SCAN domain-containing protein 3 (SCAND3) OTIIMBQL SCND3_HUMAN Decreases Methylation [10]
Opsin-5 (OPN5) OTCYGHDA OPN5_HUMAN Decreases Methylation [10]
CREB-regulated transcription coactivator 3 (CRTC3) OTVIGVUW CRTC3_HUMAN Increases Methylation [10]
Golgi-associated kinase 1B (GASK1B) OT2HPHEI GAK1B_HUMAN Decreases Methylation [10]
Transmembrane and coiled-coil domain-containing protein 3 (TMCO3) OTYW1KP2 TMCO3_HUMAN Increases Methylation [10]
Protein SNORC (SNORC) OTY3IJK5 SNORC_HUMAN Increases Methylation [10]
Inactive serine protease PAMR1 (PAMR1) OT83ZH5U PAMR1_HUMAN Increases Methylation [10]
Serine/threonine-protein kinase LMTK1 (AATK) OTVHAX5N LMTK1_HUMAN Decreases Methylation [10]
Metastasis-associated in colon cancer protein 1 (MACC1) OTV3DLX0 MACC1_HUMAN Decreases Methylation [10]
Ferric-chelate reductase 1 (FRRS1) OTQDEGEB FRRS1_HUMAN Increases Methylation [10]
Neurobeachin-like protein 2 (NBEAL2) OTMCAXWR NBEL2_HUMAN Increases Methylation [10]
Transmembrane protein 182 (TMEM182) OTVDIS2V TM182_HUMAN Increases Methylation [10]
RING finger protein 207 (RNF207) OT9AYVGV RN207_HUMAN Increases Methylation [10]
Protein ITPRID1 (ITPRID1) OT9MH0BX ITPI1_HUMAN Increases Methylation [10]
Colorectal cancer-associated protein 1 (COLCA1) OT8BP6UD COLC1_HUMAN Decreases Methylation [10]
Protein shisa-6 (SHISA6) OTWBCJ8O SHSA6_HUMAN Decreases Methylation [10]
Major facilitator superfamily domain-containing protein 6 (MFSD6) OTQ6KAV1 MFSD6_HUMAN Increases Methylation [10]
BEN domain-containing protein 4 (BEND4) OT7Z1422 BEND4_HUMAN Increases Methylation [10]
Tumor protein p63-regulated gene 1 protein (TPRG1) OTS48DQM TPRG1_HUMAN Increases Methylation [10]
Phosphoinositide 3-kinase adapter protein 1 (PIK3AP1) OTMW1B47 BCAP_HUMAN Increases Methylation [10]
Coiled-coil domain-containing protein 149 (CCDC149) OT7S7MU9 CC149_HUMAN Decreases Methylation [10]
Cytochrome P450 4V2 (CYP4V2) OTQKNK0D CP4V2_HUMAN Decreases Methylation [10]
MOB kinase activator 2 (MOB2) OTMBE0NS MOB2_HUMAN Affects Methylation [10]
RING finger protein 44 (RNF44) OTGWL4U4 RNF44_HUMAN Increases Methylation [10]
DET1 homolog (DET1) OTHYSDX3 DET1_HUMAN Increases Methylation [10]
MOB kinase activator 1B (MOB1B) OTRE19ZS MOB1B_HUMAN Increases Methylation [10]
Keratin, type I cytoskeletal 26 (KRT26) OTLAXIN0 K1C26_HUMAN Increases Methylation [10]
CUB and sushi domain-containing protein 2 (CSMD2) OT541Z3W CSMD2_HUMAN Increases Methylation [10]
Protein lifeguard 1 (GRINA) OTMC1O66 LFG1_HUMAN Increases Methylation [10]
Podocan (PODN) OTV3P7P5 PODN_HUMAN Increases Methylation [10]
Protein sidekick-1 (SDK1) OTX26906 SDK1_HUMAN Increases Methylation [10]
Ankyrin repeat and sterile alpha motif domain-containing protein 1B (ANKS1B) OT26DGM9 ANS1B_HUMAN Increases Methylation [10]
Transcription factor AP-2-delta (TFAP2D) OT71O6YN AP2D_HUMAN Decreases Methylation [10]
Pleckstrin homology domain-containing family H member 3 (PLEKHH3) OTREOQBO PKHH3_HUMAN Increases Methylation [10]
Cytokine-dependent hematopoietic cell linker (CLNK) OTOWK51S CLNK_HUMAN Decreases Methylation [10]
Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1) OTKCR5XL CK2N1_HUMAN Increases Methylation [10]
Uncharacterized protein C11orf96 (C11ORF96) OTEQU0V7 CK096_HUMAN Increases Methylation [10]
Polypeptide N-acetylgalactosaminyltransferase 5 (GALNT5) OTCV61V1 GALT5_HUMAN Increases Methylation [10]
Pleckstrin homology-like domain family B member 2 (PHLDB2) OTDKMB2G PHLB2_HUMAN Increases Methylation [10]
Protein hinderin (KIAA1328) OT2RMGGB K1328_HUMAN Increases Methylation [10]
TBC1 domain family member 1 (TBC1D1) OTI9V7B0 TBCD1_HUMAN Increases Methylation [10]
Store-operated calcium entry regulator STIMATE (STIMATE) OTEDLKEW STIMA_HUMAN Increases Methylation [10]
Armadillo-like helical domain-containing protein 4 (ARMH4) OT25GBJM ARMD4_HUMAN Increases Methylation [10]
Protein polybromo-1 (PBRM1) OT39WUR9 PB1_HUMAN Decreases Methylation [10]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (MAGI2) OTXDDKZS MAGI2_HUMAN Decreases Methylation [10]
Reticulon-4 receptor-like 1 (RTN4RL1) OTDKKOE7 R4RL1_HUMAN Increases Methylation [10]
Telomerase-binding protein EST1A (SMG6) OTRCEJQL EST1A_HUMAN Increases Methylation [10]
Leucine zipper protein 1 (LUZP1) OTQV3VZM LUZP1_HUMAN Increases Methylation [10]
Serine incorporator 5 (SERINC5) OT3COPVF SERC5_HUMAN Increases Methylation [10]
Myotubularin-related protein 13 (SBF2) OTBB8NO8 MTMRD_HUMAN Increases Methylation [10]
Histone-arginine methyltransferase CARM1 (CARM1) OT0IPRVR CARM1_HUMAN Increases Expression [12]
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) OTHCYR6Y ANKL2_HUMAN Increases Methylation [10]
Angiopoietin-related protein 5 (ANGPTL5) OTC6AFVO ANGL5_HUMAN Increases Methylation [10]
Cilium assembly protein DZIP1 (DZIP1) OTBVPO66 DZIP1_HUMAN Increases Methylation [10]
Probable guanine nucleotide exchange factor MCF2L2 (MCF2L2) OTOGFMIH MF2L2_HUMAN Increases Methylation [10]
Protein O-mannosyl-transferase TMTC1 (TMTC1) OTZ7NW96 TMTC1_HUMAN Increases Methylation [10]
Neuron navigator 3 (NAV3) OT97M1TR NAV3_HUMAN Decreases Methylation [10]
Glycerate kinase (GLYCTK) OTVTBNSM GLCTK_HUMAN Increases Methylation [10]
Aprataxin and PNK-like factor (APLF) OTYUR3AH APLF_HUMAN Increases Expression [12]
Adhesion G protein-coupled receptor A3 (ADGRA3) OTPJEV0S AGRA3_HUMAN Increases Methylation [10]
Proton-coupled zinc antiporter SLC30A8 (SLC30A8) OTF0FG5K ZNT8_HUMAN Increases Methylation [10]
Sphingosine-1-phosphate phosphatase 2 (SGPP2) OTIDIJCR SGPP2_HUMAN Increases Methylation [10]
Neuronal PAS domain-containing protein 3 (NPAS3) OT8D1ILB NPAS3_HUMAN Increases Methylation [10]
POU domain class 2-associating factor 2 (POU2AF2) OTPBW3NC OCAT1_HUMAN Increases Methylation [10]
Lamin tail domain-containing protein 2 (LMNTD2) OTKGJ1ST LMTD2_HUMAN Increases Methylation [10]
Nucleotidyltransferase MB21D2 (MB21D2) OT5C4VVU M21D2_HUMAN Increases Methylation [10]
PEX5-related protein (PEX5L) OTLR4HSR PEX5R_HUMAN Decreases Methylation [10]
Proline-, glutamic acid- and leucine-rich protein 1 (PELP1) OTVXQNOT PELP1_HUMAN Decreases Expression [12]
Voltage-dependent calcium channel subunit alpha-2/delta-3 (CACNA2D3) OTEH9HGE CA2D3_HUMAN Increases Methylation [10]
Transcription initiation factor TFIID subunit 1-like (TAF1L) OT9Z7EVA TAF1L_HUMAN Increases Methylation [10]
Leucine-rich repeat LGI family member 2 (LGI2) OTFJ2ZSG LGI2_HUMAN Decreases Methylation [10]
Regulatory-associated protein of mTOR (RPTOR) OT4TQZ9F RPTOR_HUMAN Increases Methylation [10]
UPF0462 protein C4orf33 (C4ORF33) OT3O3FC3 CD033_HUMAN Decreases Methylation [10]
Mesoderm induction early response protein 2 (MIER2) OTYURSWD MIER2_HUMAN Increases Methylation [10]
Xylosyl- and glucuronyltransferase LARGE2 (LARGE2) OT5BZS3J LARG2_HUMAN Increases Methylation [10]
Putative transporter SVOPL (SVOPL) OTJ4G2ND SVOPL_HUMAN Increases Methylation [10]
Follistatin-related protein 5 (FSTL5) OT18C29S FSTL5_HUMAN Decreases Methylation [10]
ADAMTS-like protein 1 (ADAMTSL1) OTBNYF3F ATL1_HUMAN Increases Methylation [10]
EF-hand domain-containing family member B (EFHB) OT83HFEP EFHB_HUMAN Increases Methylation [10]
Protein BANP (BANP) OT1JMTBD BANP_HUMAN Increases Methylation [10]
Sodium-dependent lysophosphatidylcholine symporter 1 (MFSD2A) OTVG1VG0 NLS1_HUMAN Increases Methylation [10]
Kyphoscoliosis peptidase (KY) OTK1L8VX KY_HUMAN Increases Methylation [10]
Clarin-3 (CLRN3) OTZDNL65 CLRN3_HUMAN Increases Methylation [10]
Exophilin-5 (EXPH5) OTOMXDUO EXPH5_HUMAN Decreases Methylation [10]
Nesprin-1 (SYNE1) OTSBSLUH SYNE1_HUMAN Increases Methylation [10]
Metalloreductase STEAP2 (STEAP2) OTGE9ETG STEA2_HUMAN Decreases Methylation [10]
Kelch repeat and BTB domain-containing protein 8 (KBTBD8) OTO8X1UF KBTB8_HUMAN Decreases Methylation [10]
Neuroligin-2 (NLGN2) OTHDYL3H NLGN2_HUMAN Increases Methylation [10]
Serine/threonine-protein kinase Nek11 (NEK11) OTMYENTC NEK11_HUMAN Decreases Methylation [10]
Olfactory receptor 5T1 (OR5T1) OTJT8C6S OR5T1_HUMAN Decreases Methylation [10]
Olfactory receptor 2AK2 (OR2AK2) OTNG4ZS1 O2AK2_HUMAN Increases Methylation [10]
Olfactory receptor 8J3 (OR8J3) OTLQYWZG OR8J3_HUMAN Decreases Methylation [10]
Olfactory receptor 8J1 (OR8J1) OTWWGQW0 OR8J1_HUMAN Decreases Methylation [10]
Olfactory receptor 4S2 (OR4S2) OTHEO86H OR4S2_HUMAN Decreases Methylation [10]
LHFPL tetraspan subfamily member 5 protein (LHFPL5) OTNDTO5B LHPL5_HUMAN Decreases Methylation [10]
SWI/SNF complex subunit SMARCC2 (SMARCC2) OTC5SNMZ SMRC2_HUMAN Decreases Expression [31]
Iron-sulfur cluster transfer protein NUBPL (NUBPL) OTQMCSXT NUBPL_HUMAN Increases Methylation [10]
DEP domain-containing mTOR-interacting protein (DEPTOR) OTCBP1BT DPTOR_HUMAN Increases Methylation [10]
T-cell immunomodulatory protein (ITFG1) OTX0PCR3 TIP_HUMAN Decreases Methylation [10]
Glutamate receptor ionotropic, NMDA 3A (GRIN3A) OTQS9GYY NMD3A_HUMAN Increases Methylation [10]
Transmembrane channel-like protein 1 (TMC1) OTHYH8MU TMC1_HUMAN Increases Methylation [10]
Polycystin-1-like protein 1 (PKD1L1) OTLAARJ1 PK1L1_HUMAN Increases Methylation [10]
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 (ASAP3) OTQB4H1J ASAP3_HUMAN Increases Methylation [10]
Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8L3) OT7XYA2T ES8L3_HUMAN Increases Methylation [10]
Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) OT83O8WI ES8L1_HUMAN Decreases Methylation [10]
Importin-4 (IPO4) OT2N5020 IPO4_HUMAN Increases Methylation [10]
Membrane progestin receptor beta (PAQR8) OTGZ8W9F PAQR8_HUMAN Decreases Methylation [10]
Dual specificity protein phosphatase 19 (DUSP19) OT0RRSG9 DUS19_HUMAN Decreases Methylation [10]
Splicing factor Cactin (CACTIN) OTO7UVK7 CATIN_HUMAN Increases Methylation [10]
AFG1-like ATPase (AFG1L) OTQ9VV5T AFG1L_HUMAN Increases Methylation [10]
Ankyrin repeat and SOCS box protein 10 (ASB10) OTYSZ9V6 ASB10_HUMAN Increases Methylation [10]
Autism susceptibility gene 2 protein (AUTS2) OTAEXHSC AUTS2_HUMAN Increases Methylation [10]
Cysteine/serine-rich nuclear protein 3 (CSRNP3) OTOANEHZ CSRN3_HUMAN Increases Methylation [10]
Phosphoinositide 3-kinase regulatory subunit 5 (PIK3R5) OT4LNXJU PI3R5_HUMAN Decreases Methylation [10]
Piezo-type mechanosensitive ion channel component 1 (PIEZO1) OTBG1FU4 PIEZ1_HUMAN Increases Methylation [10]
Phosphatidate phosphatase LPIN2 (LPIN2) OTRRTMXX LPIN2_HUMAN Increases Methylation [10]
Sorting nexin-19 (SNX19) OTGNS3HG SNX19_HUMAN Decreases Methylation [10]
Engulfment and cell motility protein 1 (ELMO1) OTY2ORXK ELMO1_HUMAN Decreases Methylation [10]
Delta-sarcoglycan (SGCD) OTRBL3NQ SGCD_HUMAN Increases Methylation [10]
A-kinase anchor protein 1, mitochondrial (AKAP1) OTIIB2JB AKAP1_HUMAN Increases Expression [12]
Estrogen receptor beta (ESR2) OTXNR2WQ ESR2_HUMAN Increases Expression [12]
Transcription initiation factor TFIID subunit 4B (TAF4B) OTCICY31 TAF4B_HUMAN Increases Methylation [10]
General transcription factor IIH subunit 4 (GTF2H4) OTPD1DIU TF2H4_HUMAN Decreases Methylation [10]
Histone acetyltransferase KAT6A (KAT6A) OT4TSQLG KAT6A_HUMAN Decreases Methylation [10]
Neuronal cell adhesion molecule (NRCAM) OT80HHQ2 NRCAM_HUMAN Increases Methylation [10]
Bcl-2-like protein 2 (BCL2L2) OTMKVO0J B2CL2_HUMAN Increases Expression [12]
Caspase-10 (CASP10) OTE6J88E CASPA_HUMAN Increases Methylation [10]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Increases Expression [36]
Fibroblast growth factor 13 (FGF13) OTHNNVSG FGF13_HUMAN Increases Methylation [10]
SWI/SNF complex subunit SMARCC1 (SMARCC1) OTUOMBE7 SMRC1_HUMAN Increases Expression [31]
Receptor-type tyrosine-protein phosphatase N2 (PTPRN2) OTL6SH28 PTPR2_HUMAN Increases Methylation [10]
Lipoma-preferred partner (LPP) OT6TU8SE LPP_HUMAN Increases Methylation [10]
Mediator of RNA polymerase II transcription subunit 12 (MED12) OTQZ4D2X MED12_HUMAN Increases Methylation [10]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (ATP2A3) OTFYDEES AT2A3_HUMAN Increases Methylation [10]
Secretory carrier-associated membrane protein 4 (SCAMP4) OTSCZTJ5 SCAM4_HUMAN Increases Methylation [10]
Endoplasmic reticulum-Golgi intermediate compartment protein 1 (ERGIC1) OT351FKB ERGI1_HUMAN Decreases Methylation [10]
Terminal nucleotidyltransferase 5B (TENT5B) OTO2P28B TET5B_HUMAN Increases Methylation [10]
Collagen alpha-1(XXVI) chain (COL26A1) OTMS7RNF COQA1_HUMAN Decreases Methylation [10]
Isochorismatase domain-containing protein 2 (ISOC2) OT69N6MB ISOC2_HUMAN Increases Methylation [10]
Repulsive guidance molecule A (RGMA) OTZAMDO2 RGMA_HUMAN Increases Methylation [10]
Dedicator of cytokinesis protein 10 (DOCK10) OTI3MBLV DOC10_HUMAN Increases Methylation [10]
EF-hand domain-containing protein D2 (EFHD2) OTM9VMN3 EFHD2_HUMAN Increases Methylation [10]
Netrin-G2 (NTNG2) OTTY88DL NTNG2_HUMAN Increases Methylation [10]
Anaphase-promoting complex subunit 16 (ANAPC16) OTG9MUYS APC16_HUMAN Increases Methylation [10]
Rho guanine nucleotide exchange factor 26 (ARHGEF26) OTX0U8PX ARHGQ_HUMAN Increases Methylation [10]
PHD finger protein 21B (PHF21B) OTU5GLCQ PF21B_HUMAN Increases Methylation [10]
Polypeptide N-acetylgalactosaminyltransferase 14 (GALNT14) OT9BSDDQ GLT14_HUMAN Increases Methylation [10]
CKLF-like MARVEL transmembrane domain-containing protein 7 (CMTM7) OTI7Q2JW CKLF7_HUMAN Decreases Methylation [10]
Aurora kinase B (AURKB) OTIY4VHU AURKB_HUMAN Decreases Expression [11]
Protein FAM163A (FAM163A) OT0MYZ0F F163A_HUMAN Increases Methylation [10]
SH3 domain-containing YSC84-like protein 1 (SH3YL1) OTVXOONW SH3Y1_HUMAN Increases Methylation [10]
ATP-binding cassette sub-family C member 11 (ABCC11) OTVHL7OR MRP8_HUMAN Increases Methylation [10]
Cadherin-related family member 1 (CDHR1) OT1ORXCM CDHR1_HUMAN Decreases Methylation [10]
Membrane-spanning 4-domains subfamily A member 4A (MS4A4A) OTWV82RP M4A4A_HUMAN Decreases Methylation [10]
Protein maelstrom homolog (MAEL) OTZ2VU30 MAEL_HUMAN Decreases Methylation [10]
MAP/microtubule affinity-regulating kinase 4 (MARK4) OT6Z2TGV MARK4_HUMAN Increases Methylation [10]
Zeta-sarcoglycan (SGCZ) OTVGTEOD SGCZ_HUMAN Decreases Methylation [10]
Adenylate kinase 8 (AK8) OT2UF6YM KAD8_HUMAN Decreases Methylation [10]
bMERB domain-containing protein 1 (BMERB1) OT1IH086 MERB1_HUMAN Increases Methylation [10]
Junctional sarcoplasmic reticulum protein 1 (JSRP1) OT1AAYWO JSPR1_HUMAN Increases Methylation [10]
Cytosolic carboxypeptidase 4 (AGBL1) OT8NQLH0 CBPC4_HUMAN Decreases Methylation [10]
Nucleolar protein 4-like (NOL4L) OT14W6UW NOL4L_HUMAN Increases Methylation [10]
Retinol dehydrogenase 12 (RDH12) OTELFRRJ RDH12_HUMAN Increases Methylation [10]
N-terminal EF-hand calcium-binding protein 3 (NECAB3) OTRASC9G NECA3_HUMAN Increases Methylation [10]
Noelin-3 (OLFM3) OTBHPDTL NOE3_HUMAN Decreases Methylation [10]
Erythroid membrane-associated protein (ERMAP) OTKXBB52 ERMAP_HUMAN Decreases Methylation [10]
CUB and sushi domain-containing protein 1 (CSMD1) OTIVDSC4 CSMD1_HUMAN Decreases Methylation [10]
PHD finger protein 12 (PHF12) OTECRO7N PHF12_HUMAN Increases Methylation [10]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1) OTMV4ASV MAGI1_HUMAN Decreases Methylation [10]
Olfactory receptor 8B4 (OR8B4) OTT4T35X OR8B4_HUMAN Decreases Methylation [10]
Galactose-3-O-sulfotransferase 4 (GAL3ST4) OTCXGJGO G3ST4_HUMAN Increases Methylation [10]
Erbin (ERBIN) OTNWTUA8 ERBIN_HUMAN Increases Methylation [10]
Intraflagellar transport protein 140 homolog (IFT140) OT6KO5FH IF140_HUMAN Increases Methylation [10]
GPI transamidase component PIG-S (PIGS) OTCC4CEN PIGS_HUMAN Increases Methylation [10]
Tetraspanin-18 (TSPAN18) OTHSGPVB TSN18_HUMAN Decreases Methylation [10]
2-aminoethanethiol dioxygenase (ADO) OTRLGQ7V AEDO_HUMAN Increases Methylation [10]
Eyes absent homolog 1 (EYA1) OTHU807A EYA1_HUMAN Decreases Methylation [10]
G-protein coupled estrogen receptor 1 (GPER1) OTUK0TDC GPER1_HUMAN Increases Expression [45]
Prohibitin-2 (PHB2) OTCAX3AW PHB2_HUMAN Decreases Expression [12]
Ataxin-2 (ATXN2) OT465IGT ATX2_HUMAN Increases Methylation [10]
Tumor susceptibility gene 101 protein (TSG101) OT97UIXC TS101_HUMAN Increases Methylation [10]
Calcium and integrin-binding protein 1 (CIB1) OT4BVCRU CIB1_HUMAN Increases Methylation [10]
Histone H2B type 1-M (H2BC14) OTSDZZZY H2B1M_HUMAN Increases Methylation [10]
Cbp/p300-interacting transactivator 2 (CITED2) OT812TV7 CITE2_HUMAN Increases Expression [12]
Semaphorin-3C (SEMA3C) OTEGUY7F SEM3C_HUMAN Increases Methylation [10]
Testican-3 (SPOCK3) OTYSOOO7 TICN3_HUMAN Decreases Methylation [10]
SH3-containing GRB2-like protein 3-interacting protein 1 (SGIP1) OTQW6R3Z SGIP1_HUMAN Increases Methylation [10]
Uncharacterized protein C7orf50 (C7ORF50) OTDHN459 CG050_HUMAN Increases Methylation [10]
Ferroptosis suppressor protein 1 (AIFM2) OT57XWXO FSP1_HUMAN Increases Methylation [10]
Phagosome assembly factor 1 (PHAF1) OTF7ZOG6 PHAF1_HUMAN Increases Methylation [10]
NEDD4 family-interacting protein 1 (NDFIP1) OTIORSWF NFIP1_HUMAN Increases Methylation [10]
Death-inducer obliterator 1 (DIDO1) OT9PB547 DIDO1_HUMAN Increases Methylation [10]
CDK5 and ABL1 enzyme substrate 2 (CABLES2) OTGD9A2A CABL2_HUMAN Increases Methylation [10]
Tubulin-specific chaperone D (TBCD) OTS4JKNQ TBCD_HUMAN Increases Methylation [10]
E3 ubiquitin-protein ligase TRIM62 (TRIM62) OT15YO6N TRI62_HUMAN Decreases Methylation [10]
PHD finger protein 20 (PHF20) OTCBVH5P PHF20_HUMAN Increases Methylation [10]
Protein TALPID3 (KIAA0586) OTOZRC1U TALD3_HUMAN Increases Methylation [10]
Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1) OTBUZ7KA KATL1_HUMAN Increases Methylation [10]
Chitinase domain-containing protein 1 (CHID1) OT4DIUKC CHID1_HUMAN Decreases Methylation [10]
Brother of CDO (BOC) OTXBCY9W BOC_HUMAN Decreases Methylation [10]
Sal-like protein 3 (SALL3) OTJ2LZKQ SALL3_HUMAN Affects Methylation [10]
Leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4) OTIMWEK5 LGR4_HUMAN Increases Methylation [10]
Hydroxycarboxylic acid receptor 1 (HCAR1) OT5ZSESQ HCAR1_HUMAN Increases Methylation [10]
Caspase recruitment domain-containing protein 11 (CARD11) OTRCTLYC CAR11_HUMAN Increases Methylation [10]
Calcium-binding protein 8 (CALN1) OTN2XE4T CABP8_HUMAN Increases Methylation [10]
R-spondin-3 (RSPO3) OTZK8GDS RSPO3_HUMAN Increases Methylation [10]
Histone deacetylase 8 (HDAC8) OT5L4RYX HDAC8_HUMAN Increases Methylation [10]
Dual specificity protein phosphatase 16 (DUSP16) OTK7S078 DUS16_HUMAN Decreases Methylation [10]
Alpha-(1,6)-fucosyltransferase (FUT8) OTJJCVG1 FUT8_HUMAN Decreases Methylation [10]
Hyccin (HYCC1) OTO65AE3 HYCCI_HUMAN Increases Methylation [10]
Keratin-associated protein 2-1 (KRTAP2-1) OTV1SGF2 KRA21_HUMAN Increases Methylation [10]
F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1) OTM3B3OA TBL1R_HUMAN Increases Methylation [10]
Reticulon-4 receptor (RTN4R) OT8J693X RTN4R_HUMAN Increases Methylation [10]
Forkhead box protein P3 (FOXP3) OTA9Z9OC FOXP3_HUMAN Increases Methylation [10]
E3 ubiquitin-protein ligase TRIM4 (TRIM4) OTLKQNKQ TRIM4_HUMAN Increases Methylation [10]
Tripartite motif-containing protein 2 (TRIM2) OT0V1YVC TRIM2_HUMAN Increases Methylation [10]
Cilia- and flagella-associated protein 74 (CFAP74) OTVW2BGR CFA74_HUMAN Increases Methylation [10]
SRC kinase signaling inhibitor 1 (SRCIN1) OTQZNQQ5 SRCN1_HUMAN Decreases Methylation [10]
Eukaryotic translation initiation factor 5A-2 (EIF5A2) OT4SY4KY IF5A2_HUMAN Decreases Methylation [10]
Hyaluronan and proteoglycan link protein 2 (HAPLN2) OT0G3KEQ HPLN2_HUMAN Decreases Methylation [10]
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) OT9AGAIJ LHPP_HUMAN Increases Methylation [10]
Transmembrane protein 168 (TMEM168) OTJKZ6G9 TM168_HUMAN Increases Methylation [10]
B-cell lymphoma/leukemia 11A (BCL11A) OTI6ZBP6 BC11A_HUMAN Increases Methylation [10]
EH domain-containing protein 4 (EHD4) OT7G5JTT EHD4_HUMAN Increases Methylation [10]
Enhancer of polycomb homolog 1 (EPC1) OT3Q25ND EPC1_HUMAN Increases Methylation [10]
Sodium-coupled neutral amino acid symporter 1 (SLC38A1) OTO3VD5E S38A1_HUMAN Increases Methylation [10]
Chordin (CHRD) OTNM60Y1 CHRD_HUMAN Increases Methylation [10]
Cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1) OT38HXJP CRLD1_HUMAN Increases Methylation [10]
Polyadenylate-binding protein 3 (PABPC3) OTTR9DPT PABP3_HUMAN Increases Methylation [10]
Tumor protein 63 (TP63) OT0WOOKQ P63_HUMAN Increases Methylation [10]
Thiamin pyrophosphokinase 1 (TPK1) OTCHPUD0 TPK1_HUMAN Increases Methylation [10]
Homeodomain-interacting protein kinase 3 (HIPK3) OT4WYQM2 HIPK3_HUMAN Increases Methylation [10]
Serine/threonine-protein kinase PLK3 (PLK3) OT19CT2Z PLK3_HUMAN Increases Methylation [10]
Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase (ST6GALNAC4) OTJCJQI7 SIA7D_HUMAN Increases Methylation [10]
PR domain zinc finger protein 13 (PRDM13) OTUNAFQW PRD13_HUMAN Increases Methylation [10]
Dual specificity protein phosphatase 21 (DUSP21) OTZAGY5R DUS21_HUMAN Decreases Methylation [10]
Uncharacterized protein C19orf44 (C19ORF44) OTES5EZZ CS044_HUMAN Increases Methylation [10]
Histone-lysine N-methyltransferase SMYD3 (SMYD3) OT9YR20G SMYD3_HUMAN Affects Methylation [10]
Proton-activated chloride channel (PACC1) OTKBS8CC PACC1_HUMAN Increases Methylation [10]
Tetratricopeptide repeat protein 12 (TTC12) OTDB24YV TTC12_HUMAN Increases Methylation [10]
Probable ATP-dependent RNA helicase DDX31 (DDX31) OTNWY581 DDX31_HUMAN Increases Methylation [10]
Protein argonaute-3 (AGO3) OTNQGROH AGO3_HUMAN Affects Methylation [10]
Akirin-1 (AKIRIN1) OTINWTT9 AKIR1_HUMAN Increases Methylation [10]
Homeobox protein NANOG (NANOG) OTUEY1FM NANOG_HUMAN Increases Expression [46]
Adhesion G protein-coupled receptor L3 (ADGRL3) OT81Q8LY AGRL3_HUMAN Decreases Methylation [10]
Protein ERGIC-53-like (LMAN1L) OT2CSBR3 LMA1L_HUMAN Increases Methylation [10]
Histone-lysine N-methyltransferase PRDM16 (PRDM16) OT0BGA27 PRD16_HUMAN Decreases Methylation [10]
Solute carrier family 38 member 10 (SLC38A10) OTXPUL6S S38AA_HUMAN Increases Methylation [10]
Mucin-5B (MUC5B) OTPW6K5C MUC5B_HUMAN Increases Methylation [10]
Transcription factor HES-4 (HES4) OTCGMQDT HES4_HUMAN Increases Methylation [10]
Helicase MOV-10 (MOV10) OT0KAY9G MOV10_HUMAN Increases Methylation [10]
Synaptotagmin-like protein 2 (SYTL2) OTUIOWKL SYTL2_HUMAN Increases Methylation [10]
E3 ubiquitin-protein ligase MSL2 (MSL2) OTVPQYBG MSL2_HUMAN Increases Methylation [10]
Mineralization regulator ANKH (ANKH) OTCN25R5 ANKH_HUMAN Decreases Methylation [10]
Roundabout homolog 2 (ROBO2) OTFJ9FQW ROBO2_HUMAN Decreases Methylation [10]
Fibrosin-1-like protein (FBRSL1) OT4BPXGG FBSL_HUMAN Increases Methylation [10]
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A) OT9X261C PDE11_HUMAN Increases Methylation [10]
LYR motif-containing protein 4 (LYRM4) OTK6JCKL LYRM4_HUMAN Increases Methylation [10]
Regulation of nuclear pre-mRNA domain-containing protein 1B (RPRD1B) OTB41D5K RPR1B_HUMAN Increases Methylation [10]
Gephyrin (GPHN) OTAKK1SV GEPH_HUMAN Increases Methylation [10]
Transcriptional and immune response regulator (TCIM) OTARUXQF TCIM_HUMAN Increases Expression [12]
Matrix-remodeling-associated protein 5 (MXRA5) OTXZBWCU MXRA5_HUMAN Decreases Methylation [10]
CTP synthase 2 (CTPS2) OT2X9YO1 PYRG2_HUMAN Increases Methylation [10]
Bromodomain adjacent to zinc finger domain protein 1A (BAZ1A) OTWHOVZS BAZ1A_HUMAN Increases Methylation [10]
Solute carrier family 2, facilitated glucose transporter member 9 (SLC2A9) OTENU71Z GTR9_HUMAN Increases Methylation [10]
Interleukin-17 receptor B (IL17RB) OT0KDNSF I17RB_HUMAN Decreases Expression [11]
Double-stranded RNA-specific editase B2 (ADARB2) OTDJKS39 RED2_HUMAN Increases Methylation [10]
Protein DEPP1 (DEPP1) OTB36PHJ DEPP1_HUMAN Decreases Expression [28]
E3 ubiquitin-protein ligase RNF146 (RNF146) OTE4CO7E RN146_HUMAN Decreases Methylation [10]
Double-stranded RNA-binding protein Staufen homolog 2 (STAU2) OTORNUIF STAU2_HUMAN Decreases Methylation [10]
tRNA:m(4)X modification enzyme TRM13 homolog (TRMT13) OT2H0MCE TRM13_HUMAN Increases Methylation [10]
F-box only protein 28 (FBXO28) OTKTMVC4 FBX28_HUMAN Decreases Methylation [10]
Transmembrane protein 51 (TMEM51) OTZCW8XJ TMM51_HUMAN Increases Methylation [10]
Solute carrier family 52, riboflavin transporter, member 1 (SLC52A1) OTQ4D276 S52A1_HUMAN Increases Methylation [10]
CUE domain-containing protein 1 (CUEDC1) OTQ7V4FF CUED1_HUMAN Increases Methylation [10]
Membrane progestin receptor gamma (PAQR5) OTGGWXQE PAQR5_HUMAN Increases Methylation [10]
Rho guanine nucleotide exchange factor 38 (ARHGEF38) OTA6K93F ARH38_HUMAN Increases Methylation [10]
Odorant-binding protein 2a (OBP2A) OTBIJ5TI OBP2A_HUMAN Increases Methylation [10]
Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) OTPT2I7B SL2A8_HUMAN Increases Methylation [10]
Sodium channel regulatory subunit beta-3 (SCN3B) OTNTQT9O SCN3B_HUMAN Decreases Methylation [10]
Probable ATP-dependent RNA helicase DDX56 (DDX56) OTGURA53 DDX56_HUMAN Increases Methylation [10]
Cytochrome c oxidase assembly factor 4 homolog, mitochondrial (COA4) OT8319UQ COA4_HUMAN Increases Methylation [10]
24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1) OTBAJT4I CP39A_HUMAN Increases Methylation [10]
Cadherin EGF LAG seven-pass G-type receptor 1 (CELSR1) OT7PS8O1 CELR1_HUMAN Increases Methylation [10]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (SMARCAL1) OTTKXLUZ SMAL1_HUMAN Decreases Methylation [10]
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) OT9G360P IF2B1_HUMAN Increases Methylation [10]
Ral guanine nucleotide dissociation stimulator-like 1 (RGL1) OTY6ZHVA RGL1_HUMAN Increases Methylation [10]
Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) OTW3T4B2 IRPL1_HUMAN Decreases Methylation [10]
CXXC-type zinc finger protein 1 (CXXC1) OTO10D1N CXXC1_HUMAN Decreases Methylation [10]
Neurotrimin (NTM) OTHF0UQU NTRI_HUMAN Decreases Methylation [10]
Costars family protein ABRACL (ABRACL) OT95T48Q ABRAL_HUMAN Increases Methylation [10]
Coiled-coil domain-containing protein 180 (CCDC180) OT4AL3LW CC180_HUMAN Increases Methylation [10]
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 (NYAP2) OT80PO4Q NYAP2_HUMAN Increases Methylation [10]
Rho GTPase-activating protein 20 (ARHGAP20) OTG1STV8 RHG20_HUMAN Increases Methylation [10]
KAT8 regulatory NSL complex subunit 3 (KANSL3) OTWXDTLY KANL3_HUMAN Decreases Methylation [10]
Arginine-glutamic acid dipeptide repeats protein (RERE) OT3G4GBZ RERE_HUMAN Increases Methylation [10]
Sperm microtubule associated protein 2 (SPMAP2) OTLJPJ39 SPMA2_HUMAN Increases Methylation [10]
Protein IMPACT (IMPACT) OTQ923OB IMPCT_HUMAN Increases Methylation [10]
Copine-7 (CPNE7) OTR0FJ8A CPNE7_HUMAN Increases Methylation [10]
Dickkopf-related protein 3 (DKK3) OTDU94EY DKK3_HUMAN Increases Methylation [10]
PTB domain-containing engulfment adapter protein 1 (GULP1) OT1WMVDH GULP1_HUMAN Increases Methylation [10]
Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1) OTU5A52J GABR1_HUMAN Increases Methylation [10]
Alpha-catulin (CTNNAL1) OTESJ6JD CTNL1_HUMAN Increases Methylation [10]
Protein CLN8 (CLN8) OT0D4CB5 CLN8_HUMAN Decreases Methylation [10]
Tripartite motif-containing protein 10 (TRIM10) OTEO4UCZ TRI10_HUMAN Increases Methylation [10]
Death domain-associated protein 6 (DAXX) OTX6O7PL DAXX_HUMAN Increases Methylation [10]
tRNA (FTSJ1) OTNE7W96 TRM7_HUMAN Increases Methylation [10]
Dynein axonemal heavy chain 17 (DNAH17) OT4G6E70 DYH17_HUMAN Increases Methylation [10]
Regulator of G-protein signaling 17 (RGS17) OT5RVUDS RGS17_HUMAN Decreases Methylation [10]
Olfactory receptor 12D3 (OR12D3) OTQ9XNBB O12D3_HUMAN Increases Methylation [10]
Deleted in malignant brain tumors 1 protein (DMBT1) OTVNU9D9 DMBT1_HUMAN Increases Expression [47]
Switch-associated protein 70 (SWAP70) OTPHT2QD SWP70_HUMAN Decreases Methylation [10]
Contactin-associated protein-like 2 (CNTNAP2) OT48T2ZP CNTP2_HUMAN Increases Methylation [10]
Interleukin-17B (IL17B) OTS86H50 IL17B_HUMAN Decreases Methylation [10]
Sodium channel protein type 11 subunit alpha (SCN11A) OTY0HJJZ SCNBA_HUMAN Increases Methylation [10]
Cardiolipin synthase (CRLS1) OT7XNL0K CRLS1_HUMAN Decreases Methylation [10]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (ENPP5) OTY807N5 ENPP5_HUMAN Decreases Methylation [10]
Anaphase-promoting complex subunit 2 (ANAPC2) OTAGLIAO ANC2_HUMAN Increases Methylation [10]
ADP-ribosylation factor-binding protein GGA1 (GGA1) OTSEV0JU GGA1_HUMAN Increases Methylation [10]
Serine/threonine-protein kinase tousled-like 1 (TLK1) OTICTXI8 TLK1_HUMAN Increases Methylation [10]
POU domain, class 2, transcription factor 3 (POU2F3) OTIOOJWD PO2F3_HUMAN Increases Methylation [10]
Mucin-12 (MUC12) OTYDC13T MUC12_HUMAN Increases Methylation [10]
F-box only protein 5 (FBXO5) OTTR957W FBX5_HUMAN Decreases Expression [11]
Histone deacetylase 9 (HDAC9) OTO8O0LF HDAC9_HUMAN Decreases Methylation [10]
Protein argonaute-2 (AGO2) OT4JY32Q AGO2_HUMAN Increases Methylation [10]
Bromodomain and PHD finger-containing protein 3 (BRPF3) OTRNO4PR BRPF3_HUMAN Increases Methylation [10]
DENN domain-containing protein 2A (DENND2A) OT01E1PL DEN2A_HUMAN Increases Methylation [10]
Cell cycle progression protein 1 (CCPG1) OT0IHDKL CCPG1_HUMAN Increases Methylation [10]
Myocardin-related transcription factor B (MRTFB) OT9OXGS9 MRTFB_HUMAN Decreases Methylation [10]
Protein HEG homolog 1 (HEG1) OT3CUXA7 HEG1_HUMAN Increases Methylation [10]
Glutamate receptor ionotropic, delta-1 (GRID1) OTJ3WIKC GRID1_HUMAN Increases Methylation [10]
Transcription factor MafF (MAFF) OT9B7MX0 MAFF_HUMAN Increases Expression [12]
Protein ATP1B4 (ATP1B4) OT2YC9GZ AT1B4_HUMAN Decreases Methylation [10]
Dual specificity protein phosphatase CDC14A (CDC14A) OTL10OY6 CC14A_HUMAN Increases Methylation [10]
FAS-associated factor 1 (FAF1) OTGAMLM4 FAF1_HUMAN Increases Methylation [10]
Protein timeless homolog (TIMELESS) OTD8DCBJ TIM_HUMAN Decreases Expression [11]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (MACF1) OTVIHD77 MACF1_HUMAN Increases Methylation [10]
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP1) OTVX8835 AGAP1_HUMAN Affects Methylation [10]
Trinucleotide repeat-containing gene 6B protein (TNRC6B) OTGVT0SH TNR6B_HUMAN Increases Methylation [10]
Transcription factor 19 (TCF19) OT7NKLF9 TCF19_HUMAN Decreases Expression [11]
Type 2 lactosamine alpha-2,3-sialyltransferase (ST3GAL6) OTB17Q43 SIA10_HUMAN Increases Methylation [10]
UDP-N-acetylglucosamine transporter (SLC35A3) OTG92DK5 S35A3_HUMAN Increases Methylation [10]
Protein strawberry notch homolog 2 (SBNO2) OT1C6J3K SBNO2_HUMAN Increases Methylation [10]
Angiomotin-like protein 2 (AMOTL2) OTRCTKV9 AMOL2_HUMAN Increases Methylation [10]
Serine/threonine-protein kinase SIK3 (SIK3) OTH0V1L5 SIK3_HUMAN Increases Methylation [10]
Peptidyl-prolyl cis-trans isomerase-like 1 (PPIL1) OTS5S837 PPIL1_HUMAN Increases Methylation [10]
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1) OT8M52QY LMBL1_HUMAN Decreases Methylation [10]
Transformation/transcription domain-associated protein (TRRAP) OT68OI2Y TRRAP_HUMAN Increases Methylation [10]
FERM, ARHGEF and pleckstrin domain-containing protein 1 (FARP1) OTL1EBTM FARP1_HUMAN Increases Methylation [10]
Centrosomal protein of 170 kDa protein B (CEP170B) OTYB0VGH C170B_HUMAN Increases Methylation [10]
Protein PRRC2C (PRRC2C) OTBX3MXM PRC2C_HUMAN Increases Methylation [10]
Ankyrin repeat and SOCS box protein 4 (ASB4) OTI4AFZL ASB4_HUMAN Increases Methylation [10]
Ankyrin repeat and SOCS box protein 3 (ASB3) OTI3TK38 ASB3_HUMAN Decreases Methylation [10]
AP-4 complex subunit sigma-1 (AP4S1) OTM3QBU8 AP4S1_HUMAN Decreases Methylation [10]
Protocadherin gamma-A1 (PCDHGA1) OTR1U1LI PCDG1_HUMAN Increases Methylation [10]
Methyltransferase N6AMT1 (N6AMT1) OTOK0NYQ N6MT1_HUMAN Increases Methylation [10]
Sorting nexin-8 (SNX8) OTMG63Z6 SNX8_HUMAN Increases Methylation [10]
Nuclear receptor corepressor 2 (NCOR2) OTY917X0 NCOR2_HUMAN Increases Methylation [10]
Junctional adhesion molecule A (F11R) OTGHPAV6 JAM1_HUMAN Decreases Methylation [10]
Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (ARFGEF1) OTPAU0L4 BIG1_HUMAN Increases Methylation [10]
Synphilin-1 (SNCAIP) OTH8VNOK SNCAP_HUMAN Increases Methylation [10]
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) OTQLO30U TAF6L_HUMAN Increases Methylation [10]
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) OT4ZSEEE IF2B2_HUMAN Increases Methylation [10]
Nuclear receptor coactivator 3 (NCOA3) OTBX300Z NCOA3_HUMAN Increases Expression [12]
Calmodulin-binding transcription activator 1 (CAMTA1) OTAN1S5B CMTA1_HUMAN Increases Methylation [10]
Ras-related and estrogen-regulated growth inhibitor (RERG) OTF6MMLV RERG_HUMAN Affects Response To Substance [31]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Decreases Response To Substance [11]
Breast cancer anti-estrogen resistance protein 3 (BCAR3) OTPJ17M8 BCAR3_HUMAN Affects Response To Substance [31]
FK506-binding protein-like (FKBPL) OTR9ND6K FKBPL_HUMAN Increases Response To Substance [48]
Anterior gradient protein 2 homolog (AGR2) OTRRZT7W AGR2_HUMAN Affects Response To Substance [49]
AT-rich interactive domain-containing protein 1A (ARID1A) OTRWDV3P ARI1A_HUMAN Decreases Response To Substance [50]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Affects Response To Substance [31]
Artemin (ARTN) OTWIWGL6 ARTN_HUMAN Decreases Response To Substance [51]
Cyclin-dependent kinase 12 (CDK12) OTZUDGNU CDK12_HUMAN Affects Response To Substance [52]
------------------------------------------------------------------------------------
⏷ Show the Full List of 985 DOT(s)
Indication(s) of Bortezomib
Disease Entry ICD 11 Status REF
Leukemia N.A. Approved [3]
Lung cancer 2C25.0 Approved [3]
Lymphoproliferative syndrome N.A. Approved [3]
MALT lymphoma N.A. Approved [3]
Mantle cell lymphoma 2A85.5 Approved [4]
Minimally invasive lung adenocarcinoma N.A. Approved [3]
Multiple myeloma 2A83 Approved [5]
Nodal marginal zone lymphoma 2A85.0 Approved [3]
Plasma cell myeloma 2A83.1 Approved [3]
Recurrent adult burkitt lymphoma 2A85.6 Approved [3]
Non-hodgkin lymphoma 2B33.5 Phase 3 [5]
B-cell neoplasm N.A. Investigative [3]
Colon cancer 2B90.Z Investigative [3]
Gastric cancer 2B72 Investigative [3]
Bortezomib Interacts with 3 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Cationic trypsinogen (PRSS1) TT2WR1T TRY1_HUMAN Inhibitor [59]
Kallikrein-related peptidase (KLK) TT5L2VC NOUNIPROTAC Inhibitor [59]
Proteasome (PS) TTU7ZMG NOUNIPROTAC Modulator [60]
------------------------------------------------------------------------------------
Bortezomib Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [61]
------------------------------------------------------------------------------------
Bortezomib Interacts with 5 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [62]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [63]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [64]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [65]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [64]
------------------------------------------------------------------------------------
Bortezomib Interacts with 686 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Expression [66]
Extended synaptotagmin-2 (ESYT2) OTWCXTX3 ESYT2_HUMAN Decreases Expression [53]
Alternative prion protein (PRNP) OTE85L1Q APRIO_HUMAN Increases Expression [53]
Serine/threonine-protein kinase Sgk1 (SGK1) OT301T1U SGK1_HUMAN Increases Expression [53]
Cytosolic acyl coenzyme A thioester hydrolase (ACOT7) OT7C68YV BACH_HUMAN Decreases Expression [53]
GTP-binding protein 1 (GTPBP1) OTA9KV6C GTPB1_HUMAN Decreases Expression [53]
Galectin-8 (LGALS8) OT71LJ8T LEG8_HUMAN Increases Expression [53]
26S proteasome non-ATPase regulatory subunit 12 (PSMD12) OTWICA51 PSD12_HUMAN Increases Expression [53]
Leukocyte-specific transcript 1 protein (LST1) OTUVG424 LST1_HUMAN Decreases Expression [53]
Agrin (AGRN) OTWJENAZ AGRIN_HUMAN Decreases Expression [53]
Krev interaction trapped protein 1 (KRIT1) OT58AP1I KRIT1_HUMAN Increases Expression [53]
Beta-1,3-N-acetylglucosaminyltransferase manic fringe (MFNG) OTUX45ZF MFNG_HUMAN Decreases Expression [53]
Pirin (PIR) OT8ALXHU PIR_HUMAN Increases Expression [53]
Pyridoxal kinase (PDXK) OT40AJ5J PDXK_HUMAN Increases Expression [53]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Decreases Expression [53]
Suppressor of cytokine signaling 3 (SOCS3) OTY183WJ SOCS3_HUMAN Increases Expression [53]
TRAF-type zinc finger domain-containing protein 1 (TRAFD1) OT7AU2R3 TRAD1_HUMAN Increases Expression [53]
Cytoplasmic dynein 1 intermediate chain 1 (DYNC1I1) OTFX1KCG DC1I1_HUMAN Increases Expression [53]
Chromodomain-helicase-DNA-binding protein 2 (CHD2) OTRKL6YC CHD2_HUMAN Increases Expression [53]
Golgi SNAP receptor complex member 2 (GOSR2) OTYHIYN2 GOSR2_HUMAN Increases Expression [53]
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) OTOKUXUH ADA10_HUMAN Decreases Expression [53]
Apolipoprotein L1 (APOL1) OT8QBVTY APOL1_HUMAN Increases Expression [53]
Interferon-inducible protein AIM2 (AIM2) OT86QUI8 AIM2_HUMAN Increases Expression [53]
Myosin regulatory light chain 12B (MYL12B) OTXMLQOT ML12B_HUMAN Increases Expression [53]
Centrosomal protein of 290 kDa (CEP290) OTVN52VH CE290_HUMAN Increases Expression [53]
Small ribosomal subunit protein uS12m (MRPS12) OTGY4GIX RT12_HUMAN Decreases Expression [53]
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) OT1Z1ZXE OGT1_HUMAN Decreases Expression [53]
V-type proton ATPase subunit e 1 (ATP6V0E1) OTZZIUYY VA0E1_HUMAN Increases Expression [53]
ATP-binding cassette sub-family C member 4 (ABCC4) OTO27PAL MRP4_HUMAN Decreases Expression [53]
Transcription factor MafG (MAFG) OTBQFUZH MAFG_HUMAN Increases Expression [53]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2) OT6Y1QZN IRAK2_HUMAN Increases Expression [53]
PHD finger protein 1 (PHF1) OTW2PSIR PHF1_HUMAN Increases Expression [53]
Synaptogyrin-2 (SYNGR2) OTJX84RI SNG2_HUMAN Decreases Expression [53]
Cytohesin-interacting protein (CYTIP) OTRJ3ZC5 CYTIP_HUMAN Increases Expression [53]
Growth arrest-specific protein 7 (GAS7) OT0M5TNY GAS7_HUMAN Decreases Expression [53]
F-box-like/WD repeat-containing protein TBL1X (TBL1X) OTXQ51E0 TBL1X_HUMAN Increases Expression [53]
Glycosaminoglycan xylosylkinase (FAM20B) OTOA0UYT XYLK_HUMAN Decreases Expression [53]
Suppressor of cytokine signaling 5 (SOCS5) OTN1ABYR SOCS5_HUMAN Increases Expression [53]
Protein tyrosine phosphatase type IVA 3 (PTP4A3) OTXMMWUN TP4A3_HUMAN Decreases Expression [53]
Deformed epidermal autoregulatory factor 1 homolog (DEAF1) OTCLX3ZW DEAF1_HUMAN Decreases Expression [53]
Calpain-15 (CAPN15) OT0WE161 CAN15_HUMAN Decreases Expression [53]
Carbonyl reductase 3 (CBR3) OT9G6SF0 CBR3_HUMAN Increases Expression [53]
Triple functional domain protein (TRIO) OT71X1AK TRIO_HUMAN Decreases Expression [53]
Cystatin-F (CST7) OTQWZUVQ CYTF_HUMAN Increases Expression [53]
ATP-dependent DNA helicase Q4 (RECQL4) OT59LSW7 RECQ4_HUMAN Increases Expression [53]
Erlin-2 (ERLIN2) OT551BVG ERLN2_HUMAN Decreases Expression [53]
Pre-mRNA-processing factor 6 (PRPF6) OT3U0ABN PRP6_HUMAN Decreases Expression [53]
Lysine-specific demethylase 4B (KDM4B) OT5P1UPY KDM4B_HUMAN Decreases Expression [53]
Methyl-CpG-binding domain protein 4 (MBD4) OTWR9YXE MBD4_HUMAN Increases Expression [53]
Arginyl-tRNA--protein transferase 1 (ATE1) OT3QNM39 ATE1_HUMAN Increases Expression [53]
GDH/6PGL endoplasmic bifunctional protein (H6PD) OTO7TNDD G6PE_HUMAN Decreases Expression [53]
NAD kinase (NADK) OTYN9GX0 NADK_HUMAN Decreases Expression [53]
AP-2 complex subunit alpha-1 (AP2A1) OTEFZB21 AP2A1_HUMAN Decreases Expression [53]
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) OTBMJUOC M4K4_HUMAN Increases Expression [53]
Acyl-CoA 6-desaturase (FADS2) OTUX531P FADS2_HUMAN Decreases Expression [53]
Phosphatidylserine lipase ABHD16A (ABHD16A) OTDS9K1Z ABHGA_HUMAN Increases Expression [53]
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) OT1TN2KT GPAN1_HUMAN Increases Expression [53]
Putative lipid scramblase CLPTM1 (CLPTM1) OT14QP7N CLPT1_HUMAN Decreases Expression [53]
Glutathione reductase, mitochondrial (GSR) OTM2TUYM GSHR_HUMAN Increases Expression [53]
HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA) OT7KZMP2 DRA_HUMAN Decreases Expression [53]
Myelin basic protein (MBP) OTFZCEDB MBP_HUMAN Decreases Expression [53]
Thy-1 membrane glycoprotein (THY1) OTVONVTB THY1_HUMAN Decreases Expression [53]
HLA class II histocompatibility antigen, DP beta 1 chain (HLA-DPB1) OTW8JHU2 DPB1_HUMAN Decreases Expression [53]
T-cell surface glycoprotein CD5 (CD5) OTC5JEG5 CD5_HUMAN Decreases Expression [53]
Alpha-galactosidase A (GLA) OTBSR6DT AGAL_HUMAN Increases Expression [53]
HLA class II histocompatibility antigen, DO alpha chain (HLA-DOA) OTZE5Q7R DOA_HUMAN Decreases Expression [53]
Cathepsin D (CTSD) OTQZ36F3 CATD_HUMAN Increases Expression [53]
Trypsin-2 (PRSS2) OTOMVUWL TRY2_HUMAN Decreases Expression [53]
Prosaposin (PSAP) OTUOEKY7 SAP_HUMAN Increases Expression [53]
Guanine nucleotide-binding protein G(i) subunit alpha-3 (GNAI3) OT89UWAR GNAI3_HUMAN Increases Expression [53]
Steryl-sulfatase (STS) OTXTJQPC STS_HUMAN Decreases Expression [53]
Monoacylglycerol lipase ABHD2 (ABHD2) OTCRUOCS ABHD2_HUMAN Increases Expression [53]
Gamma-enolase (ENO2) OTRODL0T ENOG_HUMAN Increases Expression [53]
Tropomyosin alpha-1 chain (TPM1) OTD73X6R TPM1_HUMAN Increases Expression [53]
Cancer/testis antigen family 45 member A6 (CT45A5) OTIFETOM CT456_HUMAN Increases Expression [53]
Schwannomin-interacting protein 1 (SCHIP1) OTF3FR4A SCHI1_HUMAN Decreases Expression [53]
Granzyme B (GZMB) OTPPVIRS GRAB_HUMAN Increases Expression [53]
Clusterin (CLU) OTQGG0JM CLUS_HUMAN Increases Expression [53]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Increases Expression [53]
Phenylethanolamine N-methyltransferase (PNMT) OTGLCPE8 PNMT_HUMAN Decreases Expression [53]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) OT2HZK5M GTR3_HUMAN Increases Expression [53]
Ras-related protein Ral-A (RALA) OT734R7X RALA_HUMAN Increases Expression [53]
Breakpoint cluster region protein (BCR) OTCN76C1 BCR_HUMAN Decreases Expression [53]
Glucose-6-phosphate 1-dehydrogenase (G6PD) OT300SMK G6PD_HUMAN Decreases Expression [53]
Steroid hormone receptor ERR1 (ESRRA) OTTDTUSP ERR1_HUMAN Decreases Expression [53]
B-cell antigen receptor complex-associated protein alpha chain (CD79A) OTOJC8DV CD79A_HUMAN Decreases Expression [53]
Granzyme A (GZMA) OT43R33L GRAA_HUMAN Decreases Expression [53]
Cytochrome b-245 light chain (CYBA) OT16N9ZO CY24A_HUMAN Decreases Expression [53]
Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3) OTM8EG6H AT1A3_HUMAN Decreases Expression [53]
Perforin-1 (PRF1) OTFVXD7H PERF_HUMAN Decreases Expression [53]
Insulin-degrading enzyme (IDE) OT5GQTJ5 IDE_HUMAN Increases Expression [53]
Ras-related C3 botulinum toxin substrate 2 (RAC2) OTAOHFNH RAC2_HUMAN Decreases Expression [53]
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) OT18H1B0 ERF3A_HUMAN Decreases Expression [53]
Folate receptor alpha (FOLR1) OT0QZ0H6 FOLR1_HUMAN Decreases Expression [53]
Cyclic AMP-dependent transcription factor ATF-2 (ATF2) OTNIZPEA ATF2_HUMAN Increases Expression [53]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Increases Expression [53]
Immunoglobulin lambda-like polypeptide 1 (IGLL1) OTRTNVOG IGLL1_HUMAN Decreases Expression [53]
Mucin-1 (MUC1) OTHQI7IY MUC1_HUMAN Decreases Expression [53]
Ribosyldihydronicotinamide dehydrogenase (NQO2) OTGDAJRZ NQO2_HUMAN Increases Expression [53]
Leukosialin (SPN) OTFW338K LEUK_HUMAN Decreases Expression [53]
Transcription factor JunD (JUND) OTNKACJD JUND_HUMAN Decreases Expression [53]
Integrin beta-6 (ITGB6) OTI3DJ7U ITB6_HUMAN Increases Expression [53]
Ras-related protein Rab-5A (RAB5A) OTFR2KM4 RAB5A_HUMAN Decreases Expression [53]
Integrin alpha-L (ITGAL) OTCUQAIS ITAL_HUMAN Decreases Expression [53]
B-cell lymphoma 3 protein (BCL3) OT1M5B95 BCL3_HUMAN Decreases Expression [53]
5'-nucleotidase (NT5E) OT7J5LT6 5NTD_HUMAN Decreases Expression [53]
Ephrin type-A receptor 1 (EPHA1) OTGJMRZ0 EPHA1_HUMAN Decreases Expression [53]
CD9 antigen (CD9) OT2184XU CD9_HUMAN Increases Expression [53]
Integrin alpha-6 (ITGA6) OT3FA39C ITA6_HUMAN Decreases Expression [53]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Increases Expression [53]
Tyrosine-protein kinase JAK1 (JAK1) OT0X3D17 JAK1_HUMAN Decreases Expression [53]
ER lumen protein-retaining receptor 1 (KDELR1) OT8YBS5G ERD21_HUMAN Decreases Expression [53]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [53]
Polypyrimidine tract-binding protein 1 (PTBP1) OT2OBJUK PTBP1_HUMAN Decreases Expression [53]
NKG2-D type II integral membrane protein (KLRK1) OTQWXK71 NKG2D_HUMAN Decreases Expression [53]
CD82 antigen (CD82) OTH8MC64 CD82_HUMAN Decreases Expression [53]
HLA class II histocompatibility antigen, DM beta chain (HLA-DMB) OT17HGXJ DMB_HUMAN Decreases Expression [53]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) OTG0TTX7 CD38_HUMAN Decreases Expression [53]
Ephrin type-B receptor 2 (EPHB2) OT8VZ6C5 EPHB2_HUMAN Decreases Expression [53]
Flavin reductase (BLVRB) OTHCFN2C BLVRB_HUMAN Increases Expression [53]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Decreases Expression [53]
Homeobox protein Hox-A11 (HOXA11) OT42C4HF HXA11_HUMAN Decreases Expression [53]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [53]
Stress-induced-phosphoprotein 1 (STIP1) OT7TXLOX STIP1_HUMAN Decreases Expression [53]
Guanylate-binding protein 2 (GBP2) OTVU4G07 GBP2_HUMAN Increases Expression [53]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Decreases Expression [53]
Protein phosphatase 1A (PPM1A) OT1U770U PPM1A_HUMAN Increases Expression [53]
Transcription factor 7 (TCF7) OT1ID822 TCF7_HUMAN Decreases Expression [53]
Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) OTUE7Z91 MP2K2_HUMAN Decreases Expression [53]
Transgelin-2 (TAGLN2) OTUXZGDQ TAGL2_HUMAN Decreases Expression [53]
Pre-B-cell leukemia transcription factor 3 (PBX3) OT8WMVM4 PBX3_HUMAN Decreases Expression [53]
Interleukin-15 (IL15) OTQSYWQS IL15_HUMAN Increases Expression [53]
Trifunctional enzyme subunit alpha, mitochondrial (HADHA) OTO557N2 ECHA_HUMAN Increases Expression [53]
Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) OTARRES9 IF2G_HUMAN Decreases Expression [53]
B-cell lymphoma 6 protein (BCL6) OTQAWWO1 BCL6_HUMAN Increases Expression [53]
Lysine-specific demethylase 5C (KDM5C) OTZ6E0HY KDM5C_HUMAN Decreases Expression [53]
Eukaryotic translation initiation factor 1 (EIF1) OTB4GZ0V EIF1_HUMAN Increases Expression [53]
5-hydroxytryptamine receptor 2B (HTR2B) OTM1AD9J 5HT2B_HUMAN Decreases Expression [53]
Lamina-associated polypeptide 2, isoform alpha (TMPO) OTL68EL4 LAP2A_HUMAN Decreases Expression [53]
ETS translocation variant 4 (ETV4) OT8C98UZ ETV4_HUMAN Decreases Expression [53]
Killer cell immunoglobulin-like receptor 2DS4 (KIR2DS4) OT00N6UJ KI2S4_HUMAN Decreases Expression [53]
26S proteasome regulatory subunit 6B (PSMC4) OTS3XN41 PRS6B_HUMAN Increases Expression [53]
Lys-63-specific deubiquitinase BRCC36 (BRCC3) OTK0ZN7Y BRCC3_HUMAN Decreases Expression [53]
LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1) OT729S0T LIMS1_HUMAN Increases Expression [53]
NADP-dependent malic enzyme (ME1) OTSVEUQE MAOX_HUMAN Increases Expression [53]
MAP kinase-activated protein kinase 2 (MAPKAPK2) OT460SBO MAPK2_HUMAN Decreases Expression [53]
Large ribosomal subunit protein bL19m (MRPL19) OTRBKF6R RM19_HUMAN Increases Expression [53]
Beta-arrestin-1 (ARRB1) OT2NJS37 ARRB1_HUMAN Decreases Expression [53]
Ubiquitin-conjugating enzyme E2 R1 (CDC34) OTNBK390 UB2R1_HUMAN Increases Expression [53]
Choline-phosphate cytidylyltransferase A (PCYT1A) OTMH0YLN PCY1A_HUMAN Increases Expression [53]
Protein phosphatase 1F (PPM1F) OTU0MVR7 PPM1F_HUMAN Increases Expression [53]
Protein numb homolog (NUMB) OTMB586Q NUMB_HUMAN Increases Expression [53]
Presenilin-1 (PSEN1) OTKL39RT PSN1_HUMAN Decreases Expression [53]
Cytosolic purine 5'-nucleotidase (NT5C2) OTJMF66Z 5NTC_HUMAN Increases Expression [53]
DNA ligase 4 (LIG4) OT40DNXU DNLI4_HUMAN Increases Expression [53]
Dynamin-2 (DNM2) OTUYU2U3 DYN2_HUMAN Decreases Expression [53]
Poly(A) polymerase alpha (PAPOLA) OTPHD65D PAPOA_HUMAN Decreases Expression [53]
Tyrosine-protein kinase Blk (BLK) OT1EB8MT BLK_HUMAN Decreases Expression [53]
Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1) OTF3TBTK SSDH_HUMAN Decreases Expression [53]
26S proteasome non-ATPase regulatory subunit 7 (PSMD7) OT7PZZ4K PSMD7_HUMAN Increases Expression [53]
N-sulphoglucosamine sulphohydrolase (SGSH) OTLSSEOS SPHM_HUMAN Increases Expression [53]
AF4/FMR2 family member 1 (AFF1) OTT2C78E AFF1_HUMAN Increases Expression [53]
Importin subunit alpha-1 (KPNA2) OTU7FOE6 IMA1_HUMAN Increases Expression [53]
Diacylglycerol kinase epsilon (DGKE) OTWS86AS DGKE_HUMAN Decreases Expression [53]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6) OTK13JKC MP2K6_HUMAN Decreases Expression [53]
Rho GDP-dissociation inhibitor 1 (ARHGDIA) OTEXWJDO GDIR1_HUMAN Decreases Expression [53]
Cysteine-rich protein 2 (CRIP2) OTVVJSYX CRIP2_HUMAN Decreases Expression [53]
Serine/threonine-protein phosphatase 5 (PPP5C) OTC3HT6Y PPP5_HUMAN Decreases Expression [53]
Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1) OT6W40XU P5CS_HUMAN Decreases Expression [53]
Proteinase-activated receptor 2 (F2RL1) OTMRMJ8N PAR2_HUMAN Decreases Expression [53]
Myc-associated zinc finger protein (MAZ) OTEHKN1M MAZ_HUMAN Decreases Expression [53]
ADP-ribosylation factor-like protein 4C (ARL4C) OTQ3QNNU ARL4C_HUMAN Decreases Expression [53]
Small integral membrane protein 11 (SMIM11) OTZPLVUC SIM11_HUMAN Decreases Expression [53]
Triosephosphate isomerase (TPI1) OT14KP4B TPIS_HUMAN Increases Expression [53]
Cell division control protein 42 homolog (CDC42) OT5QBC5M CDC42_HUMAN Decreases Expression [53]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Decreases Expression [53]
Large ribosomal subunit protein uL24 (RPL26) OTFNRC27 RL26_HUMAN Increases Expression [53]
cAMP-dependent protein kinase inhibitor alpha (PKIA) OT8M5GVO IPKA_HUMAN Increases Expression [53]
AP-1 complex subunit sigma-1A (AP1S1) OTQ2H8DN AP1S1_HUMAN Decreases Expression [53]
Small ribosomal subunit protein uS17 (RPS11) OTILZE44 RS11_HUMAN Increases Expression [53]
ADP-ribosylation factor 6 (ARF6) OTVV7KJO ARF6_HUMAN Increases Expression [53]
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) OT6285L4 FKB1A_HUMAN Decreases Expression [53]
Calcineurin subunit B type 1 (PPP3R1) OTGQNFJQ CANB1_HUMAN Decreases Expression [53]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A) OT9297OG 2ABA_HUMAN Increases Expression [53]
Small ubiquitin-related modifier 1 (SUMO1) OTJFD4P5 SUMO1_HUMAN Increases Expression [53]
Eukaryotic translation initiation factor 5A-1 (EIF5A) OTQ8DJX5 IF5A1_HUMAN Decreases Expression [53]
DNA-dependent protein kinase catalytic subunit (PRKDC) OTJVS4EG PRKDC_HUMAN Decreases Expression [53]
Small ribosomal subunit protein uS5m (MRPS5) OTZZR208 RT05_HUMAN Decreases Expression [53]
Spectrin beta chain, non-erythrocytic 1 (SPTBN1) OTOVM4D4 SPTB2_HUMAN Increases Expression [53]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Decreases Expression [53]
2-oxoglutarate dehydrogenase complex component E1 (OGDH) OTHGTQWF ODO1_HUMAN Decreases Expression [53]
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase , mitochondrial (ALDH6A1) OT8LCZCT MMSA_HUMAN Decreases Expression [53]
Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11) OT7EVFBK M2OM_HUMAN Decreases Expression [53]
Glutathione S-transferase Mu 4 (GSTM4) OTOTF8DU GSTM4_HUMAN Decreases Expression [53]
cAMP-responsive element modulator (CREM) OTJIJ5AL CREM_HUMAN Increases Expression [53]
Centromere protein C (CENPC) OTVJ6VE9 CENPC_HUMAN Increases Expression [53]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Expression [53]
Neurogenic locus notch homolog protein 2 (NOTCH2) OTQ3Y9PA NOTC2_HUMAN Decreases Expression [53]
CTD small phosphatase-like protein 2 (CTDSPL2) OTPF8W4P CTSL2_HUMAN Decreases Expression [53]
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) OTFH9M73 PTN11_HUMAN Decreases Expression [53]
Early activation antigen CD69 (CD69) OTGJHSVP CD69_HUMAN Increases Expression [53]
Serine/arginine-rich splicing factor 1 (SRSF1) OTF61HOV SRSF1_HUMAN Decreases Expression [53]
Rho GTPase-activating protein 1 (ARHGAP1) OT0H2ZBZ RHG01_HUMAN Decreases Expression [53]
FACT complex subunit SSRP1 (SSRP1) OT5TYJK9 SSRP1_HUMAN Decreases Expression [53]
Sodium/bile acid cotransporter 7 (SLC10A7) OTYLAWNV NTCP7_HUMAN Increases Expression [53]
Apolipoprotein B receptor (APOBR) OT9EUZX3 APOBR_HUMAN Decreases Expression [53]
Nuclear factor 1 A-type (NFIA) OTDHQ9CG NFIA_HUMAN Decreases Expression [53]
Interferon-related developmental regulator 2 (IFRD2) OT2URF18 IFRD2_HUMAN Decreases Expression [53]
Protein AF1q (MLLT11) OTG5RVHC AF1Q_HUMAN Increases Expression [53]
PR domain zinc finger protein 2 (PRDM2) OT8L7CGX PRDM2_HUMAN Decreases Expression [53]
Dual specificity protein phosphatase 4 (DUSP4) OT6WAO12 DUS4_HUMAN Decreases Expression [53]
Oxysterols receptor LXR-alpha (NR1H3) OT54YZ9I NR1H3_HUMAN Decreases Expression [53]
Chromobox protein homolog 3 (CBX3) OTOP9RLD CBX3_HUMAN Increases Expression [53]
Phosducin-like protein (PDCL) OTDNHIXG PHLP_HUMAN Increases Expression [53]
DNA-binding protein Ikaros (IKZF1) OTCW1FKL IKZF1_HUMAN Decreases Expression [53]
Protein OS-9 (OS9) OTB5B2TY OS9_HUMAN Increases Expression [53]
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5) OT404F9K FKBP5_HUMAN Decreases Expression [53]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Increases Expression [53]
Transformer-2 protein homolog alpha (TRA2A) OT5NHOO3 TRA2A_HUMAN Decreases Expression [53]
Rap guanine nucleotide exchange factor 1 (RAPGEF1) OTZ0TBN1 RPGF1_HUMAN Decreases Expression [53]
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (PDE7A) OTVDV4IT PDE7A_HUMAN Decreases Expression [53]
Nuclear transcription factor Y subunit gamma (NFYC) OTZVVEV7 NFYC_HUMAN Decreases Expression [53]
Transcription factor Dp-1 (TFDP1) OT6RZ7VT TFDP1_HUMAN Decreases Expression [53]
Fas-activated serine/threonine kinase (FASTK) OTTHFZMP FASTK_HUMAN Decreases Expression [53]
Mediator of DNA damage checkpoint protein 1 (MDC1) OTEUQH4J MDC1_HUMAN Decreases Expression [53]
Structural maintenance of chromosomes protein 1A (SMC1A) OT9ZMRK9 SMC1A_HUMAN Decreases Expression [53]
Neutral alpha-glucosidase AB (GANAB) OTYLXY4M GANAB_HUMAN Decreases Expression [53]
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) OT43TTX0 2A5D_HUMAN Decreases Expression [53]
Kinesin-like protein KIF22 (KIF22) OTY6X6BL KIF22_HUMAN Decreases Expression [53]
Killer cell immunoglobulin-like receptor 3DS1 (KIR3DS1) OTJWIO4T KI3S1_HUMAN Decreases Expression [53]
Killer cell immunoglobulin-like receptor 2DS3 (KIR2DS3) OT3PSLDL KI2S3_HUMAN Decreases Expression [53]
DAZ-associated protein 2 (DAZAP2) OTNURO9F DAZP2_HUMAN Decreases Expression [53]
Neutrophil cytosol factor 4 (NCF4) OTX007YL NCF4_HUMAN Decreases Expression [53]
kinase isozyme 2, mitochondrial (PDK2) OTM436F9 PDK2_HUMAN Decreases Expression [53]
Leucine-rich repeat-containing protein 41 (LRRC41) OT4YSBV5 LRC41_HUMAN Decreases Expression [53]
Ras suppressor protein 1 (RSU1) OTO5GHT1 RSU1_HUMAN Increases Expression [53]
Scaffold attachment factor B1 (SAFB) OTGRV2LW SAFB1_HUMAN Decreases Expression [53]
NF-kappa-B inhibitor beta (NFKBIB) OTY1ZJXH IKBB_HUMAN Increases Expression [53]
NGFI-A-binding protein 2 (NAB2) OTG4BDF3 NAB2_HUMAN Decreases Expression [53]
Neuronal pentraxin-1 (NPTX1) OTKVHCV0 NPTX1_HUMAN Decreases Expression [53]
Coiled-coil domain-containing protein 6 (CCDC6) OTXRQDYG CCDC6_HUMAN Decreases Expression [53]
Drebrin (DBN1) OTZVKG8A DREB_HUMAN Increases Expression [53]
Solute carrier family 35 member G1 (SLC35G1) OTKZUA8O S35G1_HUMAN Decreases Expression [53]
Protein mono-ADP-ribosyltransferase PARP6 (PARP6) OTWSXW4O PARP6_HUMAN Decreases Expression [53]
Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) OTN7XAUD LRRF1_HUMAN Increases Expression [53]
Polycomb group RING finger protein 3 (PCGF3) OTY7TPPZ PCGF3_HUMAN Increases Expression [53]
NAD kinase 2, mitochondrial (NADK2) OT1I8GDE NAKD2_HUMAN Increases Expression [53]
B-cell CLL/lymphoma 7 protein family member A (BCL7A) OTYFUJTP BCL7A_HUMAN Decreases Expression [53]
Glycerol-3-phosphate acyltransferase 3 (GPAT3) OTJUGPK0 GPAT3_HUMAN Increases Expression [53]
Acylglycerol kinase, mitochondrial (AGK) OTJGWBYT AGK_HUMAN Decreases Expression [53]
Vesicle transport protein SFT2C (SFT2D3) OT0IEAAR SFT2C_HUMAN Decreases Expression [53]
Transmembrane protein 41B (TMEM41B) OTW0B0KS TM41B_HUMAN Increases Expression [53]
Torsin-1A-interacting protein 1 (TOR1AIP1) OTTG8MAK TOIP1_HUMAN Decreases Expression [53]
Tetratricopeptide repeat protein 39A (TTC39A) OT80PQWX TT39A_HUMAN Increases Expression [53]
Protein furry homolog (FRY) OT74IAG2 FRY_HUMAN Increases Expression [53]
Probable E3 ubiquitin-protein ligase HECTD2 (HECTD2) OTDIBGQV HECD2_HUMAN Increases Expression [53]
G-protein coupled receptor 157 (GPR157) OTE7K9D7 GP157_HUMAN Decreases Expression [53]
Obscurin (OBSCN) OTT14OVX OBSCN_HUMAN Decreases Expression [53]
G kinase-anchoring protein 1 (GKAP1) OTHZRJ56 GKAP1_HUMAN Increases Expression [53]
Protein TASOR 2 (TASOR2) OTN4VE8H TASO2_HUMAN Decreases Expression [53]
Sushi domain-containing protein 4 (SUSD4) OTWCJTT3 SUSD4_HUMAN Decreases Expression [53]
Proteasome adapter and scaffold protein ECM29 (ECPAS) OT1C0KOI ECM29_HUMAN Increases Expression [53]
DENN domain-containing protein 4C (DENND4C) OT8SYN47 DEN4C_HUMAN Increases Expression [53]
Pecanex-like protein 4 (PCNX4) OTV474RQ PCX4_HUMAN Increases Expression [53]
Protein SPT2 homolog (SPTY2D1) OT1RY99Z SPT2_HUMAN Increases Expression [53]
CWF19-like protein 1 (CWF19L1) OTAMYTOW C19L1_HUMAN Decreases Expression [53]
U11/U12 small nuclear ribonucleoprotein 48 kDa protein (SNRNP48) OTSR6DEJ SNR48_HUMAN Increases Expression [53]
Tyrosine-protein kinase STYK1 (STYK1) OT61CSU7 STYK1_HUMAN Increases Expression [53]
SPRY domain-containing SOCS box protein 3 (SPSB3) OTHGEE2K SPSB3_HUMAN Increases Expression [53]
E3 ubiquitin-protein ligase TRIM65 (TRIM65) OTSQTK3A TRI65_HUMAN Decreases Expression [53]
Leucine-rich repeat and fibronectin type-III domain-containing protein 4 (LRFN4) OT7RWBKE LRFN4_HUMAN Decreases Expression [53]
Type-1 angiotensin II receptor-associated protein (AGTRAP) OT02N7LD ATRAP_HUMAN Decreases Expression [53]
Transmembrane protein 92 (TMEM92) OTTKJ2C0 TMM92_HUMAN Decreases Expression [53]
MICOS complex subunit MIC27 (APOOL) OTC1WT8O MIC27_HUMAN Increases Expression [53]
DnaJ homolog subfamily C member 14 (DNAJC14) OT7DPIVN DJC14_HUMAN Decreases Expression [53]
TBC1 domain family member 9 (TBC1D9) OTSSCTB5 TBCD9_HUMAN Increases Expression [53]
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) OTMQXW7S RAPH1_HUMAN Increases Expression [53]
Serine/threonine-protein kinase MARK2 (MARK2) OTJWGLUZ MARK2_HUMAN Decreases Expression [53]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) OTE8GBUR RIR2B_HUMAN Increases Expression [53]
Probable C-mannosyltransferase DPY19L4 (DPY19L4) OTQ89TXA D19L4_HUMAN Increases Expression [53]
Coiled-coil domain-containing protein 186 (CCDC186) OTONSQAD CC186_HUMAN Increases Expression [53]
C-myc promoter-binding protein (DENND4A) OT8FFZ29 MYCPP_HUMAN Increases Expression [53]
Cytochrome P450 2U1 (CYP2U1) OT6RXLXS CP2U1_HUMAN Increases Expression [53]
HAUS augmin-like complex subunit 6 (HAUS6) OT7ZVR57 HAUS6_HUMAN Increases Expression [53]
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (PIP4P1) OT991XS0 PP4P1_HUMAN Decreases Expression [53]
Kinectin (KTN1) OTQAV541 KTN1_HUMAN Increases Expression [53]
Phosphatidylcholine:ceramide cholinephosphotransferase 1 (SGMS1) OTZQE7PW SMS1_HUMAN Increases Expression [53]
Sodium-independent sulfate anion transporter (SLC26A11) OTWBV9CR S2611_HUMAN Increases Expression [53]
RNA-binding protein MEX3D (MEX3D) OTAUWRK7 MEX3D_HUMAN Decreases Expression [53]
Dynein axonemal assembly factor 5 (DNAAF5) OTN0CT52 DAAF5_HUMAN Decreases Expression [53]
Syntaxin-12 (STX12) OT5IBQ62 STX12_HUMAN Increases Expression [53]
Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3) OTNJX38T M4K3_HUMAN Increases Expression [53]
Protein FAM219A (FAM219A) OTAFZHY9 F219A_HUMAN Increases Expression [53]
Mitofusin-1 (MFN1) OTCBXQZF MFN1_HUMAN Decreases Expression [53]
Pleckstrin homology domain-containing family M member 2 (PLEKHM2) OT4ZYV73 PKHM2_HUMAN Decreases Expression [53]
Mitochondrial Rho GTPase 2 (RHOT2) OTV8WT2L MIRO2_HUMAN Decreases Expression [53]
Xaa-Arg dipeptidase (PM20D2) OTD2Y7LU P20D2_HUMAN Increases Expression [53]
Solute carrier family 38 member 6 (SLC38A6) OTIC8SHQ S38A6_HUMAN Increases Expression [53]
Abl interactor 1 (ABI1) OT5H4M62 ABI1_HUMAN Increases Expression [53]
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2) OTRUIMC4 GNT2A_HUMAN Increases Expression [53]
Protein FAM43A (FAM43A) OT5RPQRE FA43A_HUMAN Decreases Expression [53]
CAP-Gly domain-containing linker protein 4 (CLIP4) OT75KVQK CLIP4_HUMAN Increases Expression [53]
Putative transporter SVOPL (SVOPL) OTJ4G2ND SVOPL_HUMAN Decreases Expression [53]
Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) OT6WKC13 GALT4_HUMAN Increases Expression [53]
Coiled-coil domain-containing protein 82 (CCDC82) OT16EAZ7 CCD82_HUMAN Increases Expression [53]
SH2 domain-containing protein 3C (SH2D3C) OTAGXO0N SH2D3_HUMAN Decreases Expression [53]
Methyltransferase-like protein 27 (METTL27) OTOF0GTU MET27_HUMAN Decreases Expression [53]
ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1) OTM3KHIE ARFG1_HUMAN Decreases Expression [53]
Protein KRI1 homolog (KRI1) OT1IGOK7 KRI1_HUMAN Increases Expression [53]
ATPase family gene 2 protein homolog A (AFG2A) OTPZKWN7 AFG2A_HUMAN Increases Expression [53]
Equilibrative nucleobase transporter 1 (SLC43A3) OTR60ZLA S43A3_HUMAN Decreases Expression [53]
Retinol dehydrogenase 13 (RDH13) OT48VJ65 RDH13_HUMAN Increases Expression [53]
Neuropilin and tolloid-like protein 2 (NETO2) OT0YAMC0 NETO2_HUMAN Decreases Expression [53]
Polyhomeotic-like protein 3 (PHC3) OTTTLIAP PHC3_HUMAN Increases Expression [53]
Glutathione S-transferase C-terminal domain-containing protein (GSTCD) OTIIINMT GSTCD_HUMAN Decreases Expression [53]
Folliculin (FLCN) OTVM78XM FLCN_HUMAN Increases Expression [53]
Tubulin--tyrosine ligase (TTL) OTSS1CK4 TTL_HUMAN Decreases Expression [53]
Protein NEDD1 (NEDD1) OTBD6X77 NEDD1_HUMAN Increases Expression [53]
Protein FAM76A (FAM76A) OT28WHO4 FA76A_HUMAN Increases Expression [53]
Proline-rich protein 7 (PRR7) OT56XAQK PRR7_HUMAN Decreases Expression [53]
Transmembrane protein 254 (TMEM254) OTGDPU8S TM254_HUMAN Decreases Expression [53]
Retinol dehydrogenase 11 (RDH11) OTIND43N RDH11_HUMAN Increases Expression [53]
POC1 centriolar protein homolog B (POC1B) OTDIMIRZ POC1B_HUMAN Increases Expression [53]
Interferon-induced protein 44 (IFI44) OTOKSZVA IFI44_HUMAN Increases Expression [53]
Large ribosomal subunit protein uL30m (MRPL30) OT26OPYV RM30_HUMAN Decreases Expression [53]
RB1-inducible coiled-coil protein 1 (RB1CC1) OTZK8PFX RBCC1_HUMAN Increases Expression [53]
Elongator complex protein 5 (ELP5) OTW5R7YD ELP5_HUMAN Decreases Expression [53]
DDB1- and CUL4-associated factor 11 (DCAF11) OTNSGYK1 DCA11_HUMAN Decreases Expression [53]
Arginine/serine-rich protein PNISR (PNISR) OTUM02FW PNISR_HUMAN Increases Expression [53]
General transcription factor 3C polypeptide 2 (GTF3C2) OTWDANLJ TF3C2_HUMAN Decreases Expression [53]
Transmembrane protein 263 (TMEM263) OTO1RSTS TM263_HUMAN Increases Expression [53]
Protein THEM6 (THEM6) OT51SVLH THEM6_HUMAN Decreases Expression [53]
Pleckstrin homology-like domain family A member 1 (PHLDA1) OTFTWMIQ PHLA1_HUMAN Increases Expression [53]
Hexosaminidase D (HEXD) OTTMQKLM HEXD_HUMAN Decreases Expression [53]
E3 ubiquitin-protein ligase RNF138 (RNF138) OTPU0CO4 RN138_HUMAN Increases Expression [53]
Heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL) OTA6Q5E0 HNRLL_HUMAN Increases Expression [53]
Uncharacterized protein C4orf3 (C4ORF3) OT6TFN1O CD003_HUMAN Decreases Expression [53]
tRNA-splicing endonuclease subunit Sen15 (TSEN15) OT14UW31 SEN15_HUMAN Decreases Expression [53]
Palladin (PALLD) OTZ2MUJZ PALLD_HUMAN Increases Expression [53]
Protein N-lysine methyltransferase METTL21A (METTL21A) OTXJTNXY MT21A_HUMAN Increases Expression [53]
Histone acetyltransferase KAT6B (KAT6B) OTMUDTAH KAT6B_HUMAN Decreases Expression [53]
E3 ubiquitin-protein ligase rififylin (RFFL) OT85MGDH RFFL_HUMAN Increases Expression [53]
Aquaporin-3 (AQP3) OT2J7JPD AQP3_HUMAN Increases Expression [53]
Proteasome inhibitor PI31 subunit (PSMF1) OTX84WLQ PSMF1_HUMAN Decreases Expression [53]
Protein FAM168A (FAM168A) OTDXQCS5 F168A_HUMAN Increases Expression [53]
Protein NDRG1 (NDRG1) OTVO66BO NDRG1_HUMAN Increases Expression [53]
TRAF family member-associated NF-kappa-B activator (TANK) OTZSGFIK TANK_HUMAN Increases Expression [53]
Ras-related protein Rab-8B (RAB8B) OTBPUHV9 RAB8B_HUMAN Decreases Expression [53]
GTP-binding protein Rit1 (RIT1) OTVNOGOH RIT1_HUMAN Increases Expression [53]
Phosphorylase b kinase regulatory subunit beta (PHKB) OTKXZZIU KPBB_HUMAN Increases Expression [53]
BLOC-2 complex member HPS3 (HPS3) OTAKROK7 HPS3_HUMAN Decreases Expression [53]
F-box/WD repeat-containing protein 7 (FBXW7) OTJXE4OT FBXW7_HUMAN Decreases Expression [53]
Polyamine deacetylase HDAC10 (HDAC10) OTHCKKUQ HDA10_HUMAN Decreases Expression [53]
NXPE family member 3 (NXPE3) OTLVZ8W2 NXPE3_HUMAN Increases Expression [53]
Transmembrane protein 230 (TMEM230) OTAFALFV TM230_HUMAN Decreases Expression [53]
SOSS complex subunit B2 (NABP1) OTFTNFHW SOSB2_HUMAN Increases Expression [53]
Ankyrin repeat domain-containing protein 9 (ANKRD9) OT7VGO6G ANKR9_HUMAN Increases Expression [53]
ADP-ribosylation factor-like protein 8A (ARL8A) OTEYM6FA ARL8A_HUMAN Increases Expression [53]
m7GpppX diphosphatase (DCPS) OT1FZVC9 DCPS_HUMAN Decreases Expression [53]
Protein FAM241B (FAM241B) OTLISLRC F241B_HUMAN Increases Expression [53]
R3H domain-containing protein 4 (R3HDM4) OTE0Q78Q R3HD4_HUMAN Decreases Expression [53]
E3 ubiquitin-protein ligase CHFR (CHFR) OTRAD2TT CHFR_HUMAN Decreases Expression [53]
ATP-dependent DNA helicase DDX11 (DDX11) OT1WR3MD DDX11_HUMAN Decreases Expression [53]
Kelch domain-containing protein 7B (KLHDC7B) OT2H5BNX KLD7B_HUMAN Increases Expression [53]
H/ACA ribonucleoprotein complex non-core subunit NAF1 (NAF1) OTMJKJAK NAF1_HUMAN Increases Expression [53]
Histone-lysine N-methyltransferase EHMT2 (EHMT2) OTC4DWB6 EHMT2_HUMAN Decreases Expression [53]
Uncharacterized protein C9orf85 (C9ORF85) OTJWBPL3 CI085_HUMAN Increases Expression [53]
Pannexin-2 (PANX2) OTAQ2S8R PANX2_HUMAN Increases Expression [53]
Ribosomal protein S6 kinase delta-1 (RPS6KC1) OT2LRTG4 KS6C1_HUMAN Increases Expression [53]
Structural maintenance of chromosomes protein 6 (SMC6) OT3IBHQD SMC6_HUMAN Increases Expression [53]
Protein orai-2 (ORAI2) OTYISRYH ORAI2_HUMAN Decreases Expression [53]
E3 ubiquitin-protein ligase RING2 (RNF2) OTFPLOIN RING2_HUMAN Increases Expression [53]
Krueppel-like factor 6 (KLF6) OTQY9S7F KLF6_HUMAN Increases Expression [53]
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (SDHC) OTC8G2MX C560_HUMAN Decreases Expression [53]
Sigma non-opioid intracellular receptor 1 (SIGMAR1) OTDORW5C SGMR1_HUMAN Decreases Expression [53]
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A) OTVTB5R5 PI51A_HUMAN Decreases Expression [53]
Apolipoprotein L4 (APOL4) OTTOH86V APOL4_HUMAN Decreases Expression [53]
Protein NipSnap homolog 1 (NIPSNAP1) OTKXKUT8 NIPS1_HUMAN Decreases Expression [53]
Protein FAM118B (FAM118B) OTRLY4B0 F118B_HUMAN Increases Expression [53]
Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1) OTYKB9G3 SIN1_HUMAN Decreases Expression [53]
TM2 domain-containing protein 3 (TM2D3) OT6MS96W TM2D3_HUMAN Increases Expression [53]
Ferroptosis suppressor protein 1 (AIFM2) OT57XWXO FSP1_HUMAN Increases Expression [53]
Tubulin-specific chaperone D (TBCD) OTS4JKNQ TBCD_HUMAN Decreases Expression [53]
Iron-sulfur cluster assembly 1 homolog, mitochondrial (ISCA1) OTU230MC ISCA1_HUMAN Increases Expression [53]
Bublin coiled-coil protein (BBLN) OTUMVEWE BBLN_HUMAN Decreases Expression [53]
Coiled-coil domain-containing protein 32 (CCDC32) OTPPUFIF CCD32_HUMAN Increases Expression [53]
Kinesin-like protein KIFC1 (KIFC1) OTNQDS00 KIFC1_HUMAN Decreases Expression [53]
Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1) OTBUZ7KA KATL1_HUMAN Increases Expression [53]
Protein C1orf43 (C1ORF43) OTT9CVZR CA043_HUMAN Decreases Expression [53]
TM2 domain-containing protein 2 (TM2D2) OTB51WEY TM2D2_HUMAN Increases Expression [53]
Sphingosine-1-phosphate phosphatase 1 (SGPP1) OT9X54CQ SGPP1_HUMAN Increases Expression [53]
FSD1-like protein (FSD1L) OTBQ48RF FSD1L_HUMAN Increases Expression [53]
C-type lectin domain family 7 member A (CLEC7A) OTRTBH27 CLC7A_HUMAN Increases Expression [53]
Serrate RNA effector molecule homolog (SRRT) OTMYPSWV SRRT_HUMAN Decreases Expression [53]
Protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1) OT07Z2RQ PACN1_HUMAN Increases Expression [53]
Sterile alpha motif domain-containing protein 10 (SAMD10) OTBKWB5C SAM10_HUMAN Decreases Expression [53]
ATP-binding cassette sub-family A member 2 (ABCA2) OTVSYK0X ABCA2_HUMAN Decreases Expression [53]
INO80 complex subunit B (INO80B) OTSHV8JF IN80B_HUMAN Decreases Expression [53]
Uncharacterized protein C6orf62 (C6ORF62) OTGK4G35 CF062_HUMAN Increases Expression [53]
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) OT4U7SBG GBRL1_HUMAN Increases Expression [53]
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1) OTL4VJC5 NUCKS_HUMAN Decreases Expression [53]
Oxysterol-binding protein-related protein 2 (OSBPL2) OTCK671N OSBL2_HUMAN Increases Expression [53]
Dual specificity protein phosphatase 15 (DUSP15) OTS6PQYL DUS15_HUMAN Decreases Expression [53]
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (KCTD10) OT5HFZXU BACD3_HUMAN Increases Expression [53]
UPF0696 protein C11orf68 (C11ORF68) OTOKOGZ6 CK068_HUMAN Decreases Expression [53]
Differentially expressed in FDCP 6 homolog (DEF6) OTIRBYVK DEFI6_HUMAN Decreases Expression [53]
Sentrin-specific protease 3 (SENP3) OTFQDOMC SENP3_HUMAN Decreases Expression [53]
ESF1 homolog (ESF1) OTHEDM0A ESF1_HUMAN Increases Expression [53]
RNA polymerase II-associated protein 3 (RPAP3) OTCW17LF RPAP3_HUMAN Increases Expression [53]
Sin3 histone deacetylase corepressor complex component SDS3 (SUDS3) OTZ1AARI SDS3_HUMAN Increases Expression [53]
Caspase activity and apoptosis inhibitor 1 (CAAP1) OTD2DN1Z CAAP1_HUMAN Increases Expression [53]
Kinesin-like protein KIF9 (KIF9) OT7W6VI1 KIF9_HUMAN Decreases Expression [53]
E3 ubiquitin-protein ligase SMURF2 (SMURF2) OT3TRVL7 SMUF2_HUMAN Increases Expression [53]
Transcription factor IIIB 50 kDa subunit (BRF2) OT2C6TH2 BRF2_HUMAN Increases Expression [53]
Retinoid-inducible serine carboxypeptidase (SCPEP1) OT43LYEZ RISC_HUMAN Increases Expression [53]
POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1) OT0X9WGR PATZ1_HUMAN Decreases Expression [53]
DNA dC->dU-editing enzyme APOBEC-3G (APOBEC3G) OT410VP5 ABC3G_HUMAN Increases Expression [53]
DnaJ homolog subfamily C member 4 (DNAJC4) OT4BUBQU DNJC4_HUMAN Decreases Expression [53]
DNA-directed DNA/RNA polymerase mu (POLM) OT0SRIP4 DPOLM_HUMAN Decreases Expression [53]
Carbohydrate sulfotransferase 11 (CHST11) OTNJJ5Q1 CHSTB_HUMAN Decreases Expression [53]
Uncharacterized protein C14orf132 (C14ORF132) OTBVC3AO CN132_HUMAN Decreases Expression [53]
Putative RNA-binding protein Luc7-like 1 (LUC7L) OT77JDB7 LUC7L_HUMAN Increases Expression [53]
Prefoldin subunit 4 (PFDN4) OT5NRHER PFD4_HUMAN Increases Expression [53]
Solute carrier family 35 member C2 (SLC35C2) OT9H15XZ S35C2_HUMAN Decreases Expression [53]
Gephyrin (GPHN) OTAKK1SV GEPH_HUMAN Decreases Expression [53]
Endophilin-B2 (SH3GLB2) OTF7BB9S SHLB2_HUMAN Decreases Expression [53]
Muscleblind-like protein 1 (MBNL1) OTOV7J85 MBNL1_HUMAN Decreases Expression [53]
CDC42 small effector protein 2 (CDC42SE2) OT8SG9I1 C42S2_HUMAN Decreases Expression [53]
RNA-binding protein PNO1 (PNO1) OT010GIS PNO1_HUMAN Increases Expression [53]
DDB1- and CUL4-associated factor 13 (DCAF13) OTQQ0QXT DCA13_HUMAN Increases Expression [53]
FGFR1 oncogene partner 2 (FGFR1OP2) OTAHO1ZC FGOP2_HUMAN Increases Expression [53]
DNA-directed RNA polymerase III subunit RPC5 (POLR3E) OT69PWBM RPC5_HUMAN Increases Expression [53]
Anoctamin-10 (ANO10) OTG3BNOU ANO10_HUMAN Increases Expression [53]
BSD domain-containing protein 1 (BSDC1) OT853CP9 BSDC1_HUMAN Increases Expression [53]
G patch domain-containing protein 2-like (GPATCH2L) OTETUZ64 GPT2L_HUMAN Increases Expression [53]
Ceroid-lipofuscinosis neuronal protein 6 (CLN6) OT91IAYT CLN6_HUMAN Decreases Expression [53]
AFG2-interacting ribosome maturation factor (AIRIM) OTGG814L AIRIM_HUMAN Increases Expression [53]
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2) OTE69HV8 B3GN2_HUMAN Decreases Expression [53]
Opioid growth factor receptor (OGFR) OTROS6RJ OGFR_HUMAN Decreases Expression [53]
E3 ubiquitin-protein ligase KCMF1 (KCMF1) OTVTKFAU KCMF1_HUMAN Increases Expression [53]
Stromal interaction molecule 2 (STIM2) OTYNXAW0 STIM2_HUMAN Decreases Expression [53]
Inhibitor of Bruton tyrosine kinase (IBTK) OTB2GM4G IBTK_HUMAN Increases Expression [53]
Phosphatidylinositol 4-kinase beta (PI4KB) OTI9UQSU PI4KB_HUMAN Decreases Expression [53]
E3 ubiquitin-protein ligase RNF14 (RNF14) OTWX0D0H RNF14_HUMAN Increases Expression [53]
Fibulin-5 (FBLN5) OTLVNZ8U FBLN5_HUMAN Decreases Expression [53]
Beta-1,4-galactosyltransferase 6 (B4GALT6) OTBM8F2U B4GT6_HUMAN Increases Expression [53]
LIM domain-containing protein 1 (LIMD1) OTN1CG6R LIMD1_HUMAN Increases Expression [53]
Protein NDRG3 (NDRG3) OTJTJCHD NDRG3_HUMAN Decreases Expression [53]
LIM domain and actin-binding protein 1 (LIMA1) OTONPC9R LIMA1_HUMAN Increases Expression [53]
AF4/FMR2 family member 4 (AFF4) OTTL5Y8R AFF4_HUMAN Increases Expression [53]
NADH-cytochrome b5 reductase 1 (CYB5R1) OTMDHMLA NB5R1_HUMAN Increases Expression [53]
Methyl-CpG-binding domain protein 1 (MBD1) OTD19VO6 MBD1_HUMAN Decreases Expression [53]
Oxidative stress-induced growth inhibitor 1 (OSGIN1) OT9KIVZW OSGI1_HUMAN Increases Expression [53]
Cell division cycle protein 23 homolog (CDC23) OTC4O83E CDC23_HUMAN Increases Expression [53]
Anaphase-promoting complex subunit 5 (ANAPC5) OTGTJNNR APC5_HUMAN Decreases Expression [53]
Calcipressin-3 (RCAN3) OTTS3CQA RCAN3_HUMAN Decreases Expression [53]
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (ASAP1) OT4DLRYY ASAP1_HUMAN Decreases Expression [53]
Tetratricopeptide repeat protein 7A (TTC7A) OTDHLPQM TTC7A_HUMAN Decreases Expression [53]
Nucleosome assembly protein 1-like 2 (NAP1L2) OT8QI4GF NP1L2_HUMAN Increases Expression [53]
Protein PHTF1 (PHTF1) OTYCZ84A PHTF1_HUMAN Increases Expression [53]
26S proteasome non-ATPase regulatory subunit 13 (PSMD13) OTNQ351N PSD13_HUMAN Increases Expression [53]
Cytosolic carboxypeptidase 1 (AGTPBP1) OTR92JFR CBPC1_HUMAN Increases Expression [53]
Serine/threonine-protein kinase ICK (CILK1) OTWOYEYP CILK1_HUMAN Increases Expression [53]
Structural maintenance of chromosomes protein 3 (SMC3) OTWGFRHD SMC3_HUMAN Increases Expression [53]
Myotubularin-related protein 6 (MTMR6) OTQPAWI3 MTMR6_HUMAN Increases Expression [53]
Phospholipase A-2-activating protein (PLAA) OTZ7NJGA PLAP_HUMAN Increases Expression [53]
Phenylalanine--tRNA ligase alpha subunit (FARSA) OT3U1P20 SYFA_HUMAN Decreases Expression [53]
Nck-associated protein 1 (NCKAP1) OTEZQXXJ NCKP1_HUMAN Increases Expression [53]
Kelch-like protein 20 (KLHL20) OTC0SFS9 KLH20_HUMAN Increases Expression [53]
ARF GTPase-activating protein GIT1 (GIT1) OTHO92S5 GIT1_HUMAN Decreases Expression [53]
RING finger protein 11 (RNF11) OTFBJSKQ RNF11_HUMAN Increases Expression [53]
Transformation/transcription domain-associated protein (TRRAP) OT68OI2Y TRRAP_HUMAN Decreases Expression [53]
Carbohydrate sulfotransferase 2 (CHST2) OTV11IZF CHST2_HUMAN Decreases Expression [53]
G-protein-signaling modulator 3 (GPSM3) OT2MO458 GPSM3_HUMAN Decreases Expression [53]
U6 snRNA-associated Sm-like protein LSm4 (LSM4) OTLKJB3A LSM4_HUMAN Decreases Expression [53]
DNA-directed RNA polymerase III subunit RPC8 (POLR3H) OT7GM7MX RPC8_HUMAN Decreases Expression [53]
NEDD8 ultimate buster 1 (NUB1) OTWA6RTX NUB1_HUMAN Increases Expression [53]
Selenoprotein K (SELENOK) OTKM7N7P SELK_HUMAN Increases Expression [53]
Nuclear receptor coactivator 3 (NCOA3) OTBX300Z NCOA3_HUMAN Increases Expression [53]
Numb-like protein (NUMBL) OTWMTMMH NUMBL_HUMAN Increases Expression [53]
ATPase MORC2 (MORC2) OT52A8BJ MORC2_HUMAN Increases Expression [53]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Increases Expression [67]
Aldo-keto reductase family 1 member B1 (AKR1B1) OTRX72TH ALDR_HUMAN Increases Expression [67]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Increases Expression [67]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Increases Expression [67]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Affects Expression [67]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Increases Expression [67]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Increases Expression [67]
Toll-like receptor 4 (TLR4) OTP7ML3S TLR4_HUMAN Increases Expression [68]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) OTBPCU2O TR10A_HUMAN Decreases Expression [69]
NF-kappa-B inhibitor epsilon (NFKBIE) OTLAYEL9 IKBE_HUMAN Increases Stability [70]
Myc box-dependent-interacting protein 1 (BIN1) OTK8O0X8 BIN1_HUMAN Increases Expression [58]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [71]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Decreases Expression [56]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) OTLF4ZB1 IKKA_HUMAN Increases Expression [56]
Apoptosis regulatory protein Siva (SIVA1) OTDT0XZK SIVA_HUMAN Decreases Expression [58]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [72]
High affinity copper uptake protein 1 (SLC31A1) OTXLRTUB COPT1_HUMAN Decreases Degradation [73]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [58]
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) OTDTF5BU SUV91_HUMAN Decreases Expression [58]
Serine protease HTRA2, mitochondrial (HTRA2) OTC7616F HTRA2_HUMAN Affects Localization [74]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Activity [75]
Nuclear protein 1 (NUPR1) OT4FU8C0 NUPR1_HUMAN Increases Expression [76]
Toll-like receptor 2 (TLR2) OTGO5P4R TLR2_HUMAN Increases Expression [56]
DENN domain-containing protein 4B (DENND4B) OTFEO8KG DEN4B_HUMAN Increases Expression [77]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B) OTL9I7LO GA45B_HUMAN Increases Expression [77]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [77]
Natural cytotoxicity triggering receptor 1 (NCR1) OT6MZKQY NCTR1_HUMAN Decreases Expression [78]
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G) OT8V1J4M GA45G_HUMAN Increases Expression [72]
BAG family molecular chaperone regulator 3 (BAG3) OTVXYUDQ BAG3_HUMAN Increases Expression [77]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Affects Localization [74]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [79]
Insulin-like growth factor II (IGF2) OTJ4O6MW IGF2_HUMAN Decreases Response To Substance [80]
Prelamin-A/C (LMNA) OT3SG7ZR LMNA_HUMAN Increases Cleavage [81]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Decreases Expression [82]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Phosphorylation [83]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Activity [84]
Galectin-2 (LGALS2) OTY08TMQ LEG2_HUMAN Decreases Expression [58]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Increases Phosphorylation [85]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Expression [86]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Decreases Expression [56]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Decreases Expression [56]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Activity [54]
Integrin alpha-V (ITGAV) OTAM7JTR ITAV_HUMAN Increases Expression [56]
Cathepsin B (CTSB) OTP9G5QB CATB_HUMAN Increases Localization [75]
Heat shock protein HSP 90-alpha (HSP90AA1) OTLG1WPK HS90A_HUMAN Decreases Expression [56]
Heat shock protein HSP 90-beta (HSP90AB1) OTR69EG7 HS90B_HUMAN Increases Expression [68]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Increases Expression [77]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [77]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [87]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Increases Expression [68]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [77]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Decreases Expression [88]
Cytochrome c oxidase subunit 8A, mitochondrial (COX8A) OTU0NR39 COX8A_HUMAN Decreases Expression [84]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [89]
Osteopontin (SPP1) OTJGC23Y OSTP_HUMAN Decreases Expression [56]
Growth hormone receptor (GHR) OT8WUWMU GHR_HUMAN Increases Expression [68]
Parathyroid hormone-related protein (PTHLH) OTI1JF13 PTHR_HUMAN Decreases Expression [88]
Interferon-induced transmembrane protein 1 (IFITM1) OTECO1G8 IFM1_HUMAN Decreases Expression [58]
Protein Cripto (CRIPTO) OT46DZXJ TDGF1_HUMAN Increases Expression [68]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Decreases Expression [56]
Tissue factor (F3) OT3MSU3B TF_HUMAN Increases Expression [90]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Increases Expression [91]
Interleukin-1 receptor type 1 (IL1R1) OTTU8959 IL1R1_HUMAN Increases Expression [68]
Transcription factor 4 (TCF4) OTB9ASTK ITF2_HUMAN Increases Expression [68]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Decreases Phosphorylation [92]
Interleukin-7 receptor subunit alpha (IL7R) OTBMFLQQ IL7RA_HUMAN Increases Expression [56]
Heat shock 70 kDa protein 6 (HSPA6) OTH4S7WB HSP76_HUMAN Increases Expression [77]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Decreases Expression [93]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Decreases Expression [56]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Increases Expression [56]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [72]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Increases Expression [77]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Expression [94]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Affects Expression [69]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Activity [54]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Decreases Expression [56]
DnaJ homolog subfamily B member 1 (DNAJB1) OTCOSEVH DNJB1_HUMAN Increases Expression [77]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Increases Expression [68]
Pentraxin-related protein PTX3 (PTX3) OTPXHRKU PTX3_HUMAN Decreases Expression [56]
CD27 antigen (CD27) OTH7NA58 CD27_HUMAN Increases Expression [68]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Activity [82]
Calreticulin (CALR) OTYD2TR1 CALR_HUMAN Increases Expression [66]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Activity [82]
Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) OT33XNZM PTN6_HUMAN Decreases Expression [58]
SHC-transforming protein 1 (SHC1) OT1J5IRN SHC1_HUMAN Decreases Expression [56]
Nitric oxide synthase 1 (NOS1) OT7M8XVG NOS1_HUMAN Increases Expression [66]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Activity [82]
DNA replication licensing factor MCM7 (MCM7) OT6FXC6K MCM7_HUMAN Decreases Expression [58]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Increases Expression [95]
Replication protein A 14 kDa subunit (RPA3) OT8JAQGL RFA3_HUMAN Decreases Expression [58]
Pro-adrenomedullin (ADM) OT7T0TA4 ADML_HUMAN Decreases Expression [56]
Insulin receptor substrate 1 (IRS1) OTNO82CU IRS1_HUMAN Decreases Degradation [96]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [58]
Alpha-synuclein (SNCA) OTPWC1MR SYUA_HUMAN Increases Expression [68]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [97]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [72]
Small ribosomal subunit protein eS19 (RPS19) OTBKGP48 RS19_HUMAN Increases Expression [77]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [85]
Caspase-2 (CASP2) OTUDYSPP CASP2_HUMAN Increases Cleavage [77]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Increases Phosphorylation [98]
Mitogen-activated protein kinase 9 (MAPK9) OTCEVJ9E MK09_HUMAN Increases Phosphorylation [98]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [99]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [54]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Increases Expression [100]
Caspase-4 (CASP4) OTVQTV1L CASP4_HUMAN Increases Activity [85]
Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A) OT5QQB5L IDH3A_HUMAN Decreases Expression [84]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Decreases Expression [101]
Small ribosomal subunit protein mS29 (DAP3) OTNPEZYM RT29_HUMAN Increases Expression [58]
Breast cancer type 2 susceptibility protein (BRCA2) OTF1XSV1 BRCA2_HUMAN Decreases Expression [97]
Interleukin-1 receptor-associated kinase 1 (IRAK1) OT133G8J IRAK1_HUMAN Decreases Expression [56]
DNA mismatch repair protein Msh6 (MSH6) OT46FP09 MSH6_HUMAN Decreases Expression [58]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Activity [102]
Caspase-6 (CASP6) OTXLD3EC CASP6_HUMAN Increases Cleavage [87]
Hepatocyte nuclear factor 3-alpha (FOXA1) OTEBY0TD FOXA1_HUMAN Decreases Expression [56]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Increases Cleavage [72]
Histone deacetylase 4 (HDAC4) OTQNGD32 HDAC4_HUMAN Decreases Expression [58]
NACHT, LRR and PYD domains-containing protein 12 (NLRP12) OTGR132Z NAL12_HUMAN Increases Expression [56]
Beta-2-microglobulin (B2M) OTDWN6NX B2MG_HUMAN Decreases Expression [103]
C-C motif chemokine 8 (CCL8) OTCTWYN8 CCL8_HUMAN Affects Expression [69]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Affects Localization [74]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Increases Expression [68]
Nuclear factor NF-kappa-B p100 subunit (NFKB2) OTS231V7 NFKB2_HUMAN Decreases Expression [94]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Cleavage [104]
Dystonin (DST) OTHZBM4X DYST_HUMAN Increases Expression [58]
Heat shock factor protein 2 (HSF2) OTXNJIJ9 HSF2_HUMAN Increases Expression [105]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Decreases Expression [97]
Fragile X messenger ribonucleoprotein 1 (FMR1) OTWEV0T5 FMR1_HUMAN Decreases Expression [58]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [106]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [75]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Increases Cleavage [87]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Increases Expression [81]
Baculoviral IAP repeat-containing protein 1 (NAIP) OTLA925F BIRC1_HUMAN Affects Expression [94]
Chromatin assembly factor 1 subunit A (CHAF1A) OTXSSY4H CAF1A_HUMAN Decreases Expression [58]
S-phase kinase-associated protein 2 (SKP2) OTD5B41X SKP2_HUMAN Decreases Expression [107]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Increases Cleavage [104]
Bcl-2-interacting killer (BIK) OTTH1T3D BIK_HUMAN Increases Activity [75]
Interleukin-18 receptor 1 (IL18R1) OT83XMPQ IL18R_HUMAN Increases Expression [68]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Increases Expression [108]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Decreases Expression [70]
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) OTC41R1E RIPK1_HUMAN Decreases Expression [56]
Cullin-1 (CUL1) OTXPE1UZ CUL1_HUMAN Increases Expression [68]
Cullin-3 (CUL3) OTDNOAPM CUL3_HUMAN Decreases Expression [58]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Decreases Expression [94]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Cleavage [104]
Transcription elongation factor A protein-like 1 (TCEAL1) OTAPG2L5 TCAL1_HUMAN Increases Expression [68]
Interferon regulatory factor 4 (IRF4) OT1DHQ1P IRF4_HUMAN Decreases Expression [93]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Increases Activity [84]
Hsp90 co-chaperone Cdc37 (CDC37) OTYDT4A7 CDC37_HUMAN Increases Expression [68]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Expression [109]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Increases Expression [110]
Carbonic anhydrase 9 (CA9) OTNA51XT CAH9_HUMAN Decreases Expression [110]
TIR domain-containing adapter molecule 2 (TICAM2) OTK7GIJ5 TCAM2_HUMAN Increases Expression [56]
Cell division cycle and apoptosis regulator protein 1 (CCAR1) OTUXLQZZ CCAR1_HUMAN Increases Expression [111]
Ectodysplasin-A receptor-associated adapter protein (EDARADD) OT0G52MC EDAD_HUMAN Increases Expression [68]
DNA-binding death effector domain-containing protein 2 (DEDD2) OT0WXRWT DEDD2_HUMAN Increases Expression [58]
Heat shock protein 105 kDa (HSPH1) OTVRR73T HS105_HUMAN Increases Expression [72]
CREB-binding protein (CREBBP) OTPA4QGM CBP_HUMAN Decreases Expression [94]
Histone acetyltransferase KAT2B (KAT2B) OTWQITWK KAT2B_HUMAN Decreases Expression [56]
Bcl-2-like protein 2 (BCL2L2) OTMKVO0J B2CL2_HUMAN Increases Expression [112]
N-alpha-acetyltransferase 80 (NAA80) OTLWR71Z NAA80_HUMAN Decreases Expression [58]
MOB kinase activator 3A (MOB3A) OTILIOXF MOB3A_HUMAN Decreases Expression [58]
Baculoviral IAP repeat-containing protein 7 (BIRC7) OTITCGHB BIRC7_HUMAN Decreases Expression [113]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3) OTZM6MHU NLRP3_HUMAN Decreases Expression [58]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [114]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Increases Expression [66]
Cell growth regulator with EF hand domain protein 1 (CGREF1) OTBZQX97 CGRE1_HUMAN Increases Expression [68]
Myeloid differentiation primary response protein MyD88 (MYD88) OTB4D6FL MYD88_HUMAN Decreases Expression [56]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) OTJGE772 CHAC1_HUMAN Increases Expression [77]
Fanconi anemia group D2 protein (FANCD2) OTVEB5LF FACD2_HUMAN Decreases Expression [115]
Eukaryotic translation initiation factor 2A (EIF2A) OTWXELQP EIF2A_HUMAN Decreases Phosphorylation [116]
DNA replication factor Cdt1 (CDT1) OTVY53VG CDT1_HUMAN Decreases Expression [58]
Interleukin-23 subunit alpha (IL23A) OTYO99HC IL23A_HUMAN Increases Expression [68]
Transcription factor 7-like 2 (TCF7L2) OTVWPZ8B TF7L2_HUMAN Increases Expression [68]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Increases Expression [94]
Sphingosine kinase 1 (SPHK1) OTWYPBVD SPHK1_HUMAN Decreases Expression [117]
Anaphase-promoting complex subunit 11 (ANAPC11) OTK2SJXR APC11_HUMAN Decreases Expression [58]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) OT0DZGY4 E2AK3_HUMAN Increases Phosphorylation [77]
Lipid transferase CIDEB (CIDEB) OT873IYM CIDEB_HUMAN Decreases Expression [58]
Adenine DNA glycosylase (MUTYH) OTXTKI7Q MUTYH_HUMAN Decreases Expression [58]
Cell cycle progression protein 1 (CCPG1) OT0IHDKL CCPG1_HUMAN Increases Expression [56]
FAS-associated factor 1 (FAF1) OTGAMLM4 FAF1_HUMAN Increases Expression [68]
Transcription factor 19 (TCF19) OT7NKLF9 TCF19_HUMAN Decreases Expression [58]
Cyclic AMP-dependent transcription factor ATF-5 (ATF5) OT03QCLM ATF5_HUMAN Increases Expression [72]
Rho-related BTB domain-containing protein 2 (RHOBTB2) OT2DATFX RHBT2_HUMAN Increases Response To Substance [118]
Beclin-1 (BECN1) OT4X293M BECN1_HUMAN Decreases Response To Substance [119]
Palmitoyl thioesterase CPT1C (CPT1C) OT8F1MBF CPT1C_HUMAN Increases Response To Substance [118]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1) OT959A3A AT2A1_HUMAN Affects Response To Substance [120]
Histone deacetylase 6 (HDAC6) OT9W9MXQ HDAC6_HUMAN Decreases Response To Substance [121]
Serine/threonine-protein kinase 4 (STK4) OTBRYNNH STK4_HUMAN Increases Response To Substance [122]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Response To Substance [118]
Transcription factor SOX-8 (SOX8) OTEJXYZM SOX8_HUMAN Increases Response To Substance [118]
DNA repair endonuclease XPF (ERCC4) OTFIOPG1 XPF_HUMAN Increases Response To Substance [118]
Polyunsaturated fatty acid lipoxygenase ALOX12 (ALOX12) OTFL5KR5 LOX12_HUMAN Increases Response To Substance [118]
Heat shock protein beta-1 (HSPB1) OTHFZ8ED HSPB1_HUMAN Decreases Response To Substance [123]
Peroxisome proliferator-activated receptor delta (PPARD) OTI4WTOP PPARD_HUMAN Increases Response To Substance [118]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Increases Response To Substance [118]
Unconventional myosin-Va (MYO5A) OTMWLP3E MYO5A_HUMAN Increases Response To Substance [118]
Proteasome subunit beta type-5 (PSMB5) OTOZXAS6 PSB5_HUMAN Decreases Response To Substance [124]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Increases Response To Substance [125]
Mannose-binding protein C (MBL2) OTS63HG5 MBL2_HUMAN Increases Response To Substance [118]
Nucleophosmin (NPM1) OTTBYYT0 NPM_HUMAN Increases Response To Substance [126]
BRCA1-associated RING domain protein 1 (BARD1) OTTC0Z9Y BARD1_HUMAN Increases Response To Substance [125]
General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) OTVAW3P1 ERCC3_HUMAN Increases Response To Substance [118]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Increases Response To Substance [118]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1) OTY9R6FZ ERN1_HUMAN Decreases Response To Substance [85]
------------------------------------------------------------------------------------
⏷ Show the Full List of 686 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Anaplastic large cell lymphoma DCMOIAW SR Investigative [127]
Colon adenocarcinoma DC9ANP3 COLO 205 Investigative [128]
Invasive ductal carcinoma DCN5T0X T-47D Investigative [128]
------------------------------------------------------------------------------------

References

1 ClinicalTrials.gov (NCT01142401) Fulvestrant With or Without Bortezomib in Patients With Inoperable Locally Advanced or Metastatic Estrogen Receptor Positive Breast Cancer
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1015).
3 Bortezomib FDA Label
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6391).
6 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
7 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
8 Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
9 Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
10 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
11 mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
12 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
13 The Wilms' tumor suppressor WT1 induces estrogen-independent growth and anti-estrogen insensitivity in ER-positive breast cancer MCF7 cells. Oncol Rep. 2010 Apr;23(4):1109-17. doi: 10.3892/or_00000739.
14 Beta3-tubulin is induced by estradiol in human breast carcinoma cells through an estrogen-receptor dependent pathway. Cell Motil Cytoskeleton. 2009 Jul;66(7):378-88.
15 Fulvestrant: pharmacologic profile versus existing endocrine agents for the treatment of breast cancer. Ann Pharmacother. 2006 Sep;40(9):1572-83.
16 Inactivation of the pure antiestrogen fulvestrant and other synthetic estrogen molecules by UDP-glucuronosyltransferase 1A enzymes expressed in breast tissue. Mol Pharmacol. 2006 Mar;69(3):908-20.
17 Analysis of estrogen agonism and antagonism of tamoxifen, raloxifene, and ICI182780 in endometrial cancer cells: a putative role for the epidermal growth factor receptor ligand amphiregulin. J Soc Gynecol Investig. 2005 Oct;12(7):e55-67.
18 Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators. Mol Endocrinol. 2010 Jan;24(1):33-46.
19 Red clover aryl hydrocarbon receptor (AhR) and estrogen receptor (ER) agonists enhance genotoxic estrogen metabolism. Chem Res Toxicol. 2017 Nov 20;30(11):2084-2092.
20 Effect of ellagic acid on the expression of human telomerase reverse transcriptase (hTERT) alpha+beta+ transcript in estrogen receptor-positive MCF-7 breast cancer cells. Clin Biochem. 2009 Sep;42(13-14):1358-62. doi: 10.1016/j.clinbiochem.2009.05.017. Epub 2009 Jun 6.
21 Estrogen-mediated inactivation of FOXO3a by the G protein-coupled estrogen receptor GPER. BMC Cancer. 2015 Oct 15;15:702. doi: 10.1186/s12885-015-1699-6.
22 Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). Toxicol Appl Pharmacol. 2005 Dec 1;209(2):123-33. doi: 10.1016/j.taap.2005.03.015.
23 Estrogens and human papilloma virus oncogenes regulate human ether--go-go-1 potassium channel expression. Cancer Res. 2009 Apr 15;69(8):3300-7. doi: 10.1158/0008-5472.CAN-08-2036. Epub 2009 Apr 7.
24 Identification of TACC1, NOV, and PTTG1 as new candidate genes associated with endocrine therapy resistance in breast cancer. J Mol Endocrinol. 2009 Feb;42(2):87-103. doi: 10.1677/JME-08-0076. Epub 2008 Nov 4.
25 Estradiol attenuates EGF-induced rapid uPAR mobilization and cell migration via the G-protein-coupled receptor 30 in ovarian cancer cells. Int J Gynecol Cancer. 2009 Feb;19(2):214-22. doi: 10.1111/IGC.0b013e31819bcb75.
26 Antiestrogens induce transforming growth factor beta-mediated immunosuppression in breast cancer. Cancer Res. 2010 Feb 15;70(4):1314-22. doi: 10.1158/0008-5472.CAN-09-3292. Epub 2010 Feb 9.
27 Differential effects of estrogen receptor antagonists on pituitary lactotroph proliferation and prolactin release. Mol Cell Endocrinol. 2005 Jul 15;239(1-2):27-36. doi: 10.1016/j.mce.2005.04.008.
28 ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
29 Cross-talk between non-genomic and genomic signalling pathways--distinct effect profiles of environmental estrogens. Toxicol Appl Pharmacol. 2010 Jun 1;245(2):160-70. doi: 10.1016/j.taap.2010.02.015. Epub 2010 Mar 4.
30 Resveratrol modulates the phosphoinositide 3-kinase pathway through an estrogen receptor alpha-dependent mechanism: relevance in cell proliferation. Int J Cancer. 2004 Mar 20;109(2):167-73. doi: 10.1002/ijc.11720.
31 Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
32 Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer. Endocr Relat Cancer. 2011 Apr 28;18(3):333-45. doi: 10.1530/ERC-10-0262. Print 2011 Jun.
33 Effects of the environmental estrogens bisphenol A, o,p'-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7. J Steroid Biochem Mol Biol. 2002 Jan;80(1):61-70. doi: 10.1016/s0960-0760(01)00173-x.
34 Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1. Mol Endocrinol. 2010 May;24(5):969-80. doi: 10.1210/me.2009-0148. Epub 2010 Mar 8.
35 Estrogen utilization of IGF-1-R and EGF-R to signal in breast cancer cells. J Steroid Biochem Mol Biol. 2010 Feb 28;118(4-5):219-30. doi: 10.1016/j.jsbmb.2009.09.018. Epub 2009 Oct 6.
36 Regulation of expression and activity of multidrug resistance proteins MRP2 and MDR1 by estrogenic compounds in Caco-2 cells. Role in prevention of xenobiotic-induced cytotoxicity. Toxicology. 2014 Jun 5;320:46-55. doi: 10.1016/j.tox.2014.03.007. Epub 2014 Mar 28.
37 Cell cycle and anti-estrogen effects synergize to regulate cell proliferation and ER target gene expression. PLoS One. 2010 Jun 8;5(6):e11011. doi: 10.1371/journal.pone.0011011.
38 The estrogen receptor influences microtubule-associated protein tau (MAPT) expression and the selective estrogen receptor inhibitor fulvestrant downregulates MAPT and increases the sensitivity to taxane in breast cancer cells. Breast Cancer Res. 2010;12(3):R43. doi: 10.1186/bcr2598. Epub 2010 Jun 28.
39 Inhibition of estrogen receptor reduces connexin 43 expression in breast cancers. Toxicol Appl Pharmacol. 2018 Jan 1;338:182-190. doi: 10.1016/j.taap.2017.11.020. Epub 2017 Nov 24.
40 Estrogen receptor regulates E2F1 expression to mediate tamoxifen resistance. Mol Cancer Res. 2010 Mar;8(3):343-52. doi: 10.1158/1541-7786.MCR-09-0395. Epub 2010 Mar 9.
41 Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
42 Expression and mitogenic effect of fibroblast growth factor-9 in human endometriotic implant is regulated by aberrant production of estrogen. J Clin Endocrinol Metab. 2003 Nov;88(11):5547-54. doi: 10.1210/jc.2003-030597.
43 Gestational bisphenol A exposure induces fatty liver development in male offspring mice through the inhibition of HNF1b and upregulation of PPAR. Cell Biol Toxicol. 2021 Feb;37(1):65-84. doi: 10.1007/s10565-020-09535-3. Epub 2020 Jul 4.
44 Mechanisms of estrogen receptor antagonism toward p53 and its implications in breast cancer therapeutic response and stem cell regulation. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15081-6. doi: 10.1073/pnas.1009575107. Epub 2010 Aug 9.
45 Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells. J Biol Chem. 2015 Jun 19;290(25):15799-15811. doi: 10.1074/jbc.M115.641167. Epub 2015 May 11.
46 Methylparaben stimulates tumor initiating cells in ER+ breast cancer models. J Appl Toxicol. 2017 Apr;37(4):417-425. doi: 10.1002/jat.3374. Epub 2016 Sep 1.
47 The putative tumor suppressor deleted in malignant brain tumors 1 is an estrogen-regulated gene in rodent and primate endometrial epithelium. Endocrinology. 2005 Mar;146(3):1066-73. doi: 10.1210/en.2004-1304. Epub 2004 Nov 24.
48 FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy. Cancer Res. 2010 Feb 1;70(3):1090-100. doi: 10.1158/0008-5472.CAN-09-2515. Epub 2010 Jan 26.
49 Anterior gradient-2 plays a critical role in breast cancer cell growth and survival by modulating cyclin D1, estrogen receptor-alpha and survivin. Breast Cancer Res. 2010;12(3):R32. doi: 10.1186/bcr2586. Epub 2010 Jun 4.
50 ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer. Nat Genet. 2020 Feb;52(2):198-207. doi: 10.1038/s41588-019-0554-0. Epub 2020 Jan 13.
51 Artemin is estrogen regulated and mediates antiestrogen resistance in mammary carcinoma. Oncogene. 2010 Jun 3;29(22):3228-40. doi: 10.1038/onc.2010.71. Epub 2010 Mar 22.
52 CRK7 modifies the MAPK pathway and influences the response to endocrine therapy. Carcinogenesis. 2009 Oct;30(10):1696-701. doi: 10.1093/carcin/bgp187. Epub 2009 Aug 3.
53 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
54 The proteasome inhibitor bortezomib enhances the activity of docetaxel in orthotopic human pancreatic tumor xenografts. Mol Cancer Ther. 2004 Jan;3(1):59-70.
55 Caspase-2 functions upstream of mitochondria in endoplasmic reticulum stress-induced apoptosis by bortezomib in human myeloma cells. Mol Cancer Ther. 2008 Aug;7(8):2298-307. doi: 10.1158/1535-7163.MCT-08-0186.
56 Synergistic antiproliferative effect of arsenic trioxide combined with bortezomib in HL60 cell line and primary blasts from patients affected by myeloproliferative disorders. Cancer Genet Cytogenet. 2010 Jun;199(2):110-20. doi: 10.1016/j.cancergencyto.2010.02.010.
57 Bortezomib potentially inhibits cellular growth of vascular endothelial cells through suppression of G2/M transition. Cancer Sci. 2010 Jun;101(6):1403-8. doi: 10.1111/j.1349-7006.2010.01544.x. Epub 2010 Mar 15.
58 Bortezomib induces caspase-dependent apoptosis in Hodgkin lymphoma cell lines and is associated with reduced c-FLIP expression: a gene expression profiling study with implications for potential combination therapies. Leuk Res. 2008 Feb;32(2):275-85. doi: 10.1016/j.leukres.2007.05.024. Epub 2007 Jul 19.
59 Characterization of a class of peptide boronates with neutral P1 side chains as highly selective inhibitors of thrombin. J Med Chem. 1995 Apr 28;38(9):1511-22.
60 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
61 CNS uptake of bortezomib is enhanced by P-glycoprotein inhibition: implications for spinal muscular atrophy. Neurobiol Dis. 2016 Apr;88:118-24.
62 Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4, to the hepatic metabolism of the proteasome inhibitor bortezomib. Drug Metab Dispos. 2005 Nov;33(11):1723-8.
63 Human metabolism of the proteasome inhibitor bortezomib: identification of circulating metabolites. Drug Metab Dispos. 2005 Jun;33(6):771-7.
64 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
65 Investigation of drug-drug interaction potential of bortezomib in vivo in female Sprague-Dawley rats and in vitro in human liver microsomes. Drug Metab Dispos. 2006 Apr;34(4):702-8.
66 Increasing intratumor C/EBP- LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer. J Exp Clin Cancer Res. 2018 Nov 27;37(1):286. doi: 10.1186/s13046-018-0967-0.
67 Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29. Chem Biol Interact. 2011 May 30;191(1-3):239-49.
68 Induction of heme oxygenase-1 by cobalt protoporphyrin enhances the antitumour effect of bortezomib in adult T-cell leukaemia cells. Br J Cancer. 2007 Oct 22;97(8):1099-105. doi: 10.1038/sj.bjc.6604003. Epub 2007 Sep 25.
69 Bortezomib restores stroma-mediated APO2L/TRAIL apoptosis resistance in multiple myeloma. Eur J Haematol. 2010 Mar;84(3):212-22. doi: 10.1111/j.1600-0609.2009.01381.x. Epub 2009 Nov 17.
70 Efficacy and mechanism of action of the proteasome inhibitor PS-341 in T-cell lymphomas and HTLV-I associated adult T-cell leukemia/lymphoma. Oncogene. 2005 Jan 13;24(3):419-30. doi: 10.1038/sj.onc.1208212.
71 The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells. Oncogene. 2003 Aug 7;22(32):4953-63. doi: 10.1038/sj.onc.1206656.
72 The proteasome inhibitor bortezomib induces apoptosis in human retinoblastoma cell lines in vitro. Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4706-19. doi: 10.1167/iovs.06-1147.
73 Carboplatin and oxaliplatin in sequenced combination with bortezomib in ovarian tumour models. J Ovarian Res. 2013 Nov 9;6(1):78. doi: 10.1186/1757-2215-6-78.
74 Differential regulation of noxa in normal melanocytes and melanoma cells by proteasome inhibition: therapeutic implications. Cancer Res. 2005 Jul 15;65(14):6294-304. doi: 10.1158/0008-5472.CAN-05-0686.
75 PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells. J Biol Chem. 2006 Apr 28;281(17):11923-32. doi: 10.1074/jbc.M508533200. Epub 2006 Jan 30.
76 Regulation of endoplasmic reticulum stress-induced cell death by ATF4 in neuroectodermal tumor cells. J Biol Chem. 2010 Feb 26;285(9):6091-100. doi: 10.1074/jbc.M109.014092. Epub 2009 Dec 18.
77 Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells. Mol Cell Biol. 2004 Nov;24(22):9695-704. doi: 10.1128/MCB.24.22.9695-9704.2004.
78 Proteasome inhibition induces apoptosis in primary human natural killer cells and suppresses NKp46-mediated cytotoxicity. Haematologica. 2009 Apr;94(4):470-8. doi: 10.3324/haematol.13783. Epub 2009 Feb 19.
79 PCI-24781 induces caspase and reactive oxygen species-dependent apoptosis through NF-kappaB mechanisms and is synergistic with bortezomib in lymphoma cells. Clin Cancer Res. 2009 May 15;15(10):3354-65. doi: 10.1158/1078-0432.CCR-08-2365. Epub 2009 May 5.
80 Induction of steroid sulfatase expression in PC-3 human prostate cancer cells by insulin-like growth factor II. Toxicol Lett. 2013 Nov 25;223(2):109-15. doi: 10.1016/j.toxlet.2013.09.006. Epub 2013 Sep 18.
81 Bortezomib blocks the catabolic process of autophagy via a cathepsin-dependent mechanism, affects endoplasmic reticulum stress and induces caspase-dependent cell death in antiestrogen-sensitive and resistant ER+ breast cancer cells. Autophagy. 2010 Jan;6(1):19-35. doi: 10.4161/auto.6.1.10323.
82 Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells. Neuro Oncol. 2008 Jun;10(3):309-19. doi: 10.1215/15228517-2007-063. Epub 2008 Apr 29.
83 Combined effects of lapatinib and bortezomib in human epidermal receptor 2 (HER2)-overexpressing breast cancer cells and activity of bortezomib against lapatinib-resistant breast cancer cells. Cancer Sci. 2010 Oct;101(10):2220-6. doi: 10.1111/j.1349-7006.2010.01662.x. Epub 2010 Aug 5.
84 Identification of Compounds That Inhibit Estrogen-Related Receptor Alpha Signaling Using High-Throughput Screening Assays. Molecules. 2019 Feb 27;24(5):841. doi: 10.3390/molecules24050841.
85 Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis. Cancer Res. 2005 Dec 15;65(24):11658-66. doi: 10.1158/0008-5472.CAN-05-2370.
86 Combination chemotherapy increases cytotoxicity of multiple myeloma cells by modification of nuclear factor (NF)-B activity. Exp Hematol. 2013 Feb;41(2):209-18. doi: 10.1016/j.exphem.2012.10.002. Epub 2012 Oct 11.
87 Inhibition of p38alpha MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X(L), Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo. Leukemia. 2006 Jun;20(6):1017-27. doi: 10.1038/sj.leu.2404200.
88 A novel bioluminescent mouse model and effective therapy for adult T-cell leukemia/lymphoma. Cancer Res. 2007 Dec 15;67(24):11859-66. doi: 10.1158/0008-5472.CAN-07-1701.
89 Reduction in BCL-2 levels by 26S proteasome inhibition with bortezomib is associated with induction of apoptosis in small cell lung cancer. Lung Cancer. 2005 Aug;49(2):163-70. doi: 10.1016/j.lungcan.2005.01.006.
90 Activation of coagulation by lenalidomide-based regimens for the treatment of multiple myeloma. PLoS One. 2013 May 16;8(5):e64369. doi: 10.1371/journal.pone.0064369. Print 2013.
91 Cell death by bortezomib-induced mitotic catastrophe in natural killer lymphoma cells. Mol Cancer Ther. 2008 Dec;7(12):3807-15. doi: 10.1158/1535-7163.MCT-08-0641.
92 Distinct Orchestration and Dynamic Processes on -H2AX and p-H3 for Two Major Types of Genotoxic Chemicals Revealed by Mass Spectrometry Analysis. Chem Res Toxicol. 2020 Aug 17;33(8):2108-2119. doi: 10.1021/acs.chemrestox.0c00104. Epub 2020 Jun 17.
93 The selective activator protein-1 inhibitor T-5224 regulates the IRF4/MYC axis and exerts cooperative antimyeloma activity with bortezomib. Chem Biol Interact. 2023 Oct 1;384:110687. doi: 10.1016/j.cbi.2023.110687. Epub 2023 Aug 31.
94 Bortezomib and Arsenic Trioxide Activity on a Myelodysplastic Cell Line (P39): A Gene Expression Study. Turk J Haematol. 2015 Sep;32(3):206-12. doi: 10.4274/tjh.2014.0058.
95 Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib. Leuk Res. 2008 Nov;32(11):1674-83. doi: 10.1016/j.leukres.2008.03.039. Epub 2008 May 15.
96 Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade. Mol Cancer Ther. 2005 Oct;4(10):1533-40. doi: 10.1158/1535-7163.MCT-05-0068.
97 Bortezomib-induced "BRCAness" sensitizes multiple myeloma cells to PARP inhibitors. Blood. 2011 Dec 8;118(24):6368-79. doi: 10.1182/blood-2011-06-363911. Epub 2011 Sep 13.
98 The novel polyamine analogue CGC-11093 enhances the antimyeloma activity of bortezomib. Cancer Res. 2008 Jun 15;68(12):4783-90. doi: 10.1158/0008-5472.CAN-07-6483.
99 Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model. Mol Cancer Ther. 2009 Apr;8(4):959-70. doi: 10.1158/1535-7163.MCT-08-0905.
100 SAHA induces apoptosis in hepatoma cells and synergistically interacts with the proteasome inhibitor Bortezomib. Apoptosis. 2007 Jul;12(7):1327-38. doi: 10.1007/s10495-007-0063-y.
101 Combination therapy with IFN-alpha plus bortezomib induces apoptosis and inhibits angiogenesis in human bladder cancer cells. Mol Cancer Ther. 2006 Dec;5(12):3032-41. doi: 10.1158/1535-7163.MCT-05-0474.
102 Bortezomib-mediated proteasome inhibition as a potential strategy for the treatment of rhabdomyosarcoma. Eur J Cancer. 2008 Apr;44(6):876-84. doi: 10.1016/j.ejca.2008.02.022. Epub 2008 Mar 14.
103 [Salvage therapy with proteasome inhibitor bortezomib for relapsed and refractory multiple myeloma]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Dec;14(6):1146-50.
104 Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341. Blood. 2003 Feb 15;101(4):1530-4. doi: 10.1182/blood-2002-08-2543. Epub 2002 Sep 26.
105 The proteasome inhibitor bortezomib is a potent inducer of zinc finger AN1-type domain 2a gene expression: role of heat shock factor 1 (HSF1)-heat shock factor 2 (HSF2) heterocomplexes. J Biol Chem. 2014 May 2;289(18):12705-15. doi: 10.1074/jbc.M113.513242. Epub 2014 Mar 11.
106 Bortezomib induces apoptosis in human neuroblastoma CHP126 cells. Pharmazie. 2010 Mar;65(3):213-8.
107 S-phase kinase protein 2 is an attractive therapeutic target in a subset of diffuse large B-cell lymphoma. J Pathol. 2008 Dec;216(4):483-94. doi: 10.1002/path.2433.
108 Long-term incubation with proteasome inhibitors (PIs) induces IB degradation via the lysosomal pathway in an IB kinase (IKK)-dependent and IKK-independent manner. J Biol Chem. 2013 Nov 8;288(45):32777-32786. doi: 10.1074/jbc.M113.480921. Epub 2013 Oct 1.
109 TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window. Hepatology. 2007 Mar;45(3):649-58. doi: 10.1002/hep.21555.
110 A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer. Clin Cancer Res. 2005 Aug 1;11(15):5526-33. doi: 10.1158/1078-0432.CCR-05-0081.
111 Curcumin suppresses growth of mesothelioma cells in vitro and in vivo, in part, by stimulating apoptosis. Mol Cell Biochem. 2011 Nov;357(1-2):83-94. doi: 10.1007/s11010-011-0878-2. Epub 2011 May 19.
112 [Inducing-apoptosis effect of bortezomib on acute monocytic leukemia cell SHI-1 and its influence on expressions of Bcl2l12, Bcl-2 and Bax genes]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Oct;16(5):1016-20.
113 [Effects of bortezomib alone or combined with arsenic trioxide on the apoptosis of Jurkat cells and expression of livin mRNA]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Aug;19(4):898-901.
114 The anti-apoptotic protein BCL2L1/Bcl-xL is neutralized by pro-apoptotic PMAIP1/Noxa in neuroblastoma, thereby determining bortezomib sensitivity independent of prosurvival MCL1 expression. J Biol Chem. 2010 Mar 5;285(10):6904-12. doi: 10.1074/jbc.M109.038331. Epub 2010 Jan 5.
115 Targeting the Fanconi anemia/BRCA pathway circumvents drug resistance in multiple myeloma. Cancer Res. 2009 Dec 15;69(24):9367-75. doi: 10.1158/0008-5472.CAN-09-2616.
116 Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA. Blood. 2008 Oct 1;112(7):2917-26. doi: 10.1182/blood-2007-12-130823. Epub 2008 Jul 18.
117 Bortezomib and sphingosine kinase inhibitor interact synergistically to induces apoptosis in BCR/ABl+ cells sensitive and resistant to STI571 through down-regulation Mcl-1. Biochem Biophys Res Commun. 2011 Feb 4;405(1):31-6. doi: 10.1016/j.bbrc.2010.12.111. Epub 2010 Dec 30.
118 Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial. Lancet Oncol. 2010 Nov;11(11):1057-65. doi: 10.1016/S1470-2045(10)70206-0. Epub 2010 Sep 21.
119 Tumor cells can evade dependence on autophagy through adaptation. Biochem Biophys Res Commun. 2012 Aug 31;425(3):684-8. doi: 10.1016/j.bbrc.2012.07.090. Epub 2012 Jul 25.
120 Preferential cytotoxicity of bortezomib toward highly malignant human liposarcoma cells via suppression of MDR1 expression and function. Toxicol Appl Pharmacol. 2015 Feb 15;283(1):1-8. doi: 10.1016/j.taap.2014.12.015. Epub 2015 Jan 6.
121 Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells. Cancer Res. 2006 Apr 1;66(7):3773-81. doi: 10.1158/0008-5472.CAN-05-2961.
122 Activation of sterile20-like kinase 1 in proteasome inhibitor bortezomib-induced apoptosis in oncogenic K-ras-transformed cells. Cancer Res. 2006 Jun 15;66(12):6072-9. doi: 10.1158/0008-5472.CAN-06-0125.
123 Blockade of Hsp27 overcomes Bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells. Cancer Res. 2003 Oct 1;63(19):6174-7.
124 Molecular mechanisms of bortezomib resistant adenocarcinoma cells. PLoS One. 2011;6(12):e27996. doi: 10.1371/journal.pone.0027996. Epub 2011 Dec 22.
125 Suppression of BRCA1 sensitizes cells to proteasome inhibitors. Cell Death Dis. 2014 Dec 18;5(12):e1580. doi: 10.1038/cddis.2014.537.
126 Role of cysteine 288 in nucleophosmin cytoplasmic mutations: sensitization to toxicity induced by arsenic trioxide and bortezomib. Leukemia. 2013 Oct;27(10):1970-80. doi: 10.1038/leu.2013.222. Epub 2013 Jul 23.
127 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
128 Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.