Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSOX7I)

Drug Name

Cocaine Drug Info

Synonyms

Allococaine; Allopseudococaine; Badrock; Bazooka; Benzoylethylecgonine; Benzoylmethylecgonine; Bernice; Bernies; Blast; Blizzard; Blow; Burese; COC; Cabello; Candy; Carrie; Caviar; Cecil; Charlie; Cholly; Coca; Cocain; Cocaina; Cocainum; Cocktail; Coke; Cola; Corine; Crack; Eritroxilina; Erytroxylin; Flake; Flex; Freeze; Girl; Goofball; Heaven; Hell; Jam; Kokain; Kokan; Kokayeen; Lady; Leaf; Moonrocks; Neurocaine; Pseudoallococaine; Rock; Sleighride; Snort; Snow; Toke; Toot; Trails; Yeyo; Bernice [Street Name]; Blow [Street Name]; Bouncing Powder; Cecil [Street Name]; Chicken Scratch; Cocaine [BAN]; Cocaine free base; Cocaine solution; Crack cocaine; Dama blanca; Ecgonine methyl ester benzoate; Ecgonine methyl ester benzoate solution; Flake [Street Name]; Florida Snow; Foo Foo; Girl [Street Name]; Gold dust; Gold dust [Street Name]; Green gold; Happy dust; Happy dust [Street Name]; Happy powder; Happy trails; Lady [Street Name]; Methyl Benzoylecgonine; Nose candy; Prime Time; Rock [Street Name]; Sweet Stuff; Toot [Street Name]; White girl or lady; Beta-Cocain; C" Carrie; Cocaine (TN); Cocaine (USP); Cocaine-M; G-Rock; Kibbles n' Bits; L-Cocain; L-Cocaine; Pimp's drug; Snow (birds); Star-spangled powder; Ecgonine, methyl ester, benzoate (ester); Methyl 3beta-hydroxy-1alphaH,5alphaH-tropane-2beta-carboxylate benzoate (ester); Methyl 3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate; Methyl 3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate; Methyl (3S,4R)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate; Methyl (1S,4R,5R)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate; (-)-Cocaine; (-)-Cocaine base; (1R,2R,3S,5S)-2-(methoxycarbonyl)tropan-3-yl benzoate; (1R,2R,3S,5S)-2-Methoxycarbonyltropan-3-yl benzoate; (R)-Cocaine; 1-Cocaine; 2-beta-Carbomethoxy-3-beta-benzoxytropane; 2-beta-Tropanecarboxylic acid, 3-beta-hydroxy-, methyl ester, benzoate (ester); 2beta-Carbomethoxy-3beta-benzoxytropane; 3-Tropanylbenzoate-2-carboxylic acid methyl ester; 3beta-Hydroxy-2beta-tropanecarboxylic acid methyl ester benzoate (ester)

Indication

Disease Entry	ICD 11	Status	REF
Anaesthesia	9A78.6	Approved	[1] , [2] , [3]

Therapeutic Class

Anesthetics

Cross-matching ID

PubChem CID: 446220
ChEBI ID: CHEBI:27958
CAS Number: CAS 50-36-2
TTD Drug ID: DMSOX7I
VARIDT Drug ID: DR00530
INTEDE Drug ID: DR0365

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Solid tumour/cancer	2A00-2F9Z	Approved	[10]
Progesterone	DMUY35B	Premature labour	JB00	Approved	[11]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[12]
Estradiol	DMUNTE3	Breast cancer	2C60-2C65	Approved	[13]
Acetaminophen	DMUIE76	Pain	MG30-MG3Z	Approved	[14]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[15]
Etoposide	DMNH3PG	Solid tumour/cancer	2A00-2F9Z	Approved	[16]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[17]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[11]
Verapamil	DMA7PEW	Hypertension	BA00-BA04	Approved	[18]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Solid tumour/cancer	2A00-2F9Z	Approved	[19]
Progesterone	DMUY35B	Premature labour	JB00	Approved	[20]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[21]
Acetaminophen	DMUIE76	Pain	MG30-MG3Z	Approved	[14]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[22]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[23]
Dopamine	DMPGUCF	Parkinson disease	8A00.0	Approved	[24]
Nicotine	DMWX5CO	Nicotine dependence	6C4A.2	Approved	[25]
Propranolol	DM79NTF	Migraine	8A80	Approved	[26]
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Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Progesterone	DMUY35B	Premature labour	JB00	Approved	[28]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[29]
Estradiol	DMUNTE3	Breast cancer	2C60-2C65	Approved	[8]
Acetaminophen	DMUIE76	Pain	MG30-MG3Z	Approved	[30]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[31]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Etoposide	DMNH3PG	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Verapamil	DMA7PEW	Hypertension	BA00-BA04	Approved	[34]
Sorafenib	DMS8IFC	Hepatocellular carcinoma	2C12.02	Approved	[8]
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Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Premature labour	JB00	Approved	[35]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[8]
Estradiol	DMUNTE3	Breast cancer	2C60-2C65	Approved	[8]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[8]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[5]
Verapamil	DMA7PEW	Hypertension	BA00-BA04	Approved	[36]
Sorafenib	DMS8IFC	Hepatocellular carcinoma	2C12.02	Approved	[8]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[8]
Irinotecan	DMP6SC2	Colorectal cancer	2B91.Z	Approved	[8]
Metronidazole	DMTIVEN	Amoebiasis	1A36	Approved	[37]
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Drug(s) Targeting Norepinephrine transporter (NET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Pain	MG30-MG3Z	Approved	[38]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[39]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[40]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[38]
Bupropion	DM5PCS7	Smoking dependence	6C4A.2	Approved	[41]
Tapentadol hydrochloride	DMXLSH3	Acute pain	MG31	Approved	[42]
Venlafaxine	DMR6QH0	Depression	6A70-6A7Z	Approved	[41]
Trimipramine	DM1SC8M	Major depressive disorder	6A70.3	Approved	[43]
Duloxetine	DM9BI7M	Depression	6A70-6A7Z	Approved	[44]
Levomilnacipran	DMV26S8	Fibromyalgia	MG30.01	Approved	[45]
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Drug(s) Targeting Serotonin transporter (SERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Pain	MG30-MG3Z	Approved	[38]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[39]
Fluoxetine	DM3PD2C	Depression	6A70-6A7Z	Approved	[46]
Vortioxetine	DM6F1PU	Major depressive disorder	6A70.3	Approved	[47]
Sertraline	DM0FB1J	Depression	6A70-6A7Z	Approved	[48]
Bupropion	DM5PCS7	Smoking dependence	6C4A.2	Approved	[41]
Citalopram	DM2G9AE	Depression	6A70-6A7Z	Approved	[46]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[46]
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[46]
Paroxetine	DM5PVQE	Depression	6A70-6A7Z	Approved	[46]
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Drug(s) Targeting Dopamine transporter (DAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasotraline	DMLDQFV	Attention deficit hyperactivity disorder	6A05.Z	Approved	[49]
Methylphenidate	DM7SJD6	Attention deficit hyperactivity disorder	6A05.Z	Approved	[50]
Modafinil	DMYILBE	Narcolepsy	7A20	Approved	[46]
Phenmetrazine	DMXYTN9	Obesity	5B81	Approved	[51]
Ioflupane I-123	DMNARJT	Parkinson disease	8A00.0	Approved	[3]
Dexmethylphenidate hydrochloride	DM8WBAH	Attention deficit hyperactivity disorder	6A05.Z	Approved	[52]
Altropane	DMO9WDS	Attention deficit hyperactivity disorder	6A05.Z	Approved	[53]
Bupropion+Naltrexone	DMAR9ND	Obesity	5B81	Phase 3	[54]
Amitifadine	DMS1X67	Obesity	5B81	Phase 3	[55]
NAV5001	DMRSI1M	Dementia	6D80-6D86	Phase 3	[53]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine transporter (DAT)	TTVBI8W	SC6A3_HUMAN	Inhibitor	[4]
Norepinephrine transporter (NET)	TTAWNKZ	SC6A2_HUMAN	Inhibitor	[4]
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Inhibitor	[4]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[5]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[6]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[7]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Substrate	[8]
Butyrylcholine esterase (BCHE)	DEIHSMD	CHLE_HUMAN	Substrate	[9]

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