Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSE3I7)

Drug Name
Gemcitabine Drug Info
Synonyms
Gemcitabine hydrochloride; DDFC; DFdC; DFdCyd; Folfugem; GEO; Gamcitabine; GemLip; Gemcel; Gemcin; Gemcitabina; Gemcitabinum; Gemtro; Gemzar; Zefei; Gemcitabine HCl; Gemcitabine stereoisomer; LY 188011; LY188011; Gemcitabina [INN-Spanish]; Gemcitabinum [INN-Latin]; Gemzar (TN); Gemzar (hydrochloride); Inno-D07001; LY-188011; Gemcitabine (USAN/INN)
Indication
Disease Entry ICD 11 Status REF
Anterior urethra cancer Approved [1]
Biliary tract cancer 2C17 Approved [1]
Carcinoma 2A00-2F9Z Approved [1]
Cervical cancer 2C77.0 Approved [1]
Cholangiocarcinoma 2C12.10 Approved [1]
Fallopian tube neoplasm Approved [1]
Gallbladder carcinoma Approved [1]
Leiomyosarcoma 2B58 Approved [1]
Leukemia Approved [1]
Lung cancer 2C25.0 Approved [1]
MALT lymphoma Approved [1]
Nodal marginal zone lymphoma 2A85.0 Approved [1]
Non-small-cell lung cancer 2C25 Approved [2]
Ovarian disorder Approved [1]
Ovarian neoplasm Approved [1]
Pancreatic adenocarcinoma Approved [1]
Pancreatic ductal carcinoma 2C10.0 Approved [1]
Pancreatic tumour 2C10 Approved [1]
Posterior urethra cancer Approved [1]
Recurrent adult burkitt lymphoma 2A85.6 Approved [1]
Solid tumour/cancer 2A00-2F9Z Approved [3]
Splenic marginal zone lymphoma Approved [1]
Urethral cancer 2C93 Approved [1]
Urinary bladder neoplasm Approved [1]
Middle East Respiratory Syndrome (MERS) 1D64 Preclinical [4]
Severe acute respiratory syndrome (SARS) 1D65 Preclinical [4]
Colon cancer 2B90.Z Investigative [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
60750
ChEBI ID
CHEBI:175901
CAS Number
CAS 95058-81-4
TTD Drug ID
DMSE3I7
VARIDT Drug ID
DR00063
INTEDE Drug ID
DR0765

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Ribonucleoside-diphosphate reductase M2 (RRM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [5]
CO-101 DMH5GQU Pancreatic cancer 2C10 Phase 2 [19]
Triapine DM7XZY5 Nerve injury ND56.4 Phase 2 [20]
CALAA-01 DMT4Z5B Solid tumour/cancer 2A00-2F9Z Phase 1 [21]
LY-2334737 DMCBV20 Solid tumour/cancer 2A00-2F9Z Phase 1 [22]
Gallium maltolate DMX0Z51 Human immunodeficiency virus infection 1C62 Discontinued in Phase 2 [23]
MDL 101,731 DMKEYSX Gastric adenocarcinoma 2B72 Discontinued in Phase 2 [24]
NKP-46 DMK8UD0 Solid tumour/cancer 2A00-2F9Z Preclinical [25]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [26]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [27]
Methotrexate DM2TEOL Anterior urethra cancer Approved [28]
Folic Acid DMEMBJC Colorectal carcinoma Approved [29]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [28]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [28]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [30]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [28]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [31]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [32]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Multidrug resistance-associated protein 5 (ABCC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [33]
Folic Acid DMEMBJC Colorectal carcinoma Approved [33]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [34]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [35]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [36]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [37]
FLUORESCEIN DMQTFAO Ocular disease 1F00.1Z Approved [38]
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [39]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [40]
[3H]cAMP DMZRQU7 Discovery agent N.A. Investigative [41]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Concentrative nucleoside transporter 1 (SLC28A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [42]
Uridine DMQTREB Depression 6A70-6A7Z Approved [43]
Trifluridine DMG2YBD Herpetic keratitis 1F00.10 Approved [44]
Drug(s) Metabolized By Cytidine aminohydrolase (CDA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [45]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [46]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [47]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [48]
Drug(s) Metabolized By Cytidine deaminase (cdd)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [12]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [12]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [12]
Drug(s) Affected By Cytidine deaminase (CDA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [49]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [53]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [54]
Testosterone DM7HUNW Hot flushes GA30 Approved [55]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [59]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [60]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [61]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [62]
Cepharanthine DM9Y5JB N. A. N. A. Approved [63]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [64]
Clozapine DMFC71L Schizophrenia 6A20 Approved [65]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [66]
Trifluoperazine DMKBYWI Anxiety Approved [67]
Olanzapine DMPFN6Y Bipolar depression Approved [65]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 (RRM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [68]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [72]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [73]
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [74]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ribonucleoside-diphosphate reductase large subunit (RRM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [79]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [79]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [81]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [83]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [84]
Selenium DM25CGV N. A. N. A. Approved [85]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [81]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [86]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [88]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [89]
Gefitinib DM15F0X Colon adenocarcinoma Approved [90]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [91]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [92]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [93]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [94]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Selenium DM25CGV N. A. N. A. Approved [96]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [97]
Quercetin DM3NC4M Obesity 5B81 Approved [98]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [99]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [100]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [101]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [102]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Verapamil DMA7PEW Angina pectoris BA40 Approved [104]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [105]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [107]
Flucytosine DM13VTW Cryptococcal meningitis Approved [108]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NF-kappa-B inhibitor epsilon (NFKBIE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [109]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [110]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [111]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Bortezomib DMNO38U Leukemia Approved [112]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [50]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [113]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [114]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [115]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [116]
Methotrexate DM2TEOL Anterior urethra cancer Approved [117]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [118]
Quercetin DM3NC4M Obesity 5B81 Approved [119]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [120]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stearoyl-CoA desaturase (SCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [123]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [124]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [124]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [126]
Fluoxetine DM3PD2C Bipolar depression Approved [124]
Fructose DM43AN2 Vomiting MD90 Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [124]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [128]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [129]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [130]
Testosterone DM7HUNW Hot flushes GA30 Approved [55]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [131]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [133]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [134]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Fluoxetine DM3PD2C Bipolar depression Approved [137]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [120]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [139]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [138]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [140]
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [141]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase Praja-2 (PJA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Indomethacin DMSC4A7 Bursitis Approved [143]
Urethane DM7NSI0 N. A. N. A. Phase 4 [144]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [145]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [146]
Milchsaure DM462BT Pruritus EC90 Investigative [147]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-1 receptor-associated kinase-like 2 (IRAK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [129]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [148]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [120]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [149]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [150]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [151]
Quercetin DM3NC4M Obesity 5B81 Approved [152]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [153]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [154]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [155]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [156]
Testosterone DM7HUNW Hot flushes GA30 Approved [55]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [157]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [158]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [159]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [160]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [140]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Selenium DM25CGV N. A. N. A. Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Testosterone enanthate DMB6871 N. A. N. A. Approved [163]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [164]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Ethanol DMDRQZU Chronic pain MG30 Approved [165]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Melanoma-associated antigen C1 (MAGEC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [167]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [168]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [169]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [170]
Drug(s) Affected By Liprin-alpha-4 (PPFIA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Ethanol DMDRQZU Chronic pain MG30 Approved [171]
Arsenic DMTL2Y1 N. A. N. A. Approved [172]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [173]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [131]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [174]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [175]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [176]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [177]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Maf (MAF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [129]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [130]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [178]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [179]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [180]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [50]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [181]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [182]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [94]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [84]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [183]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [184]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [185]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [186]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Krueppel-like factor 8 (KLF8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [187]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [167]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [188]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [189]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [176]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [177]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [157]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [190]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [98]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [190]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [191]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [192]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibrinogen gamma chain (FGG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [193]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [194]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [195]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [196]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [197]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [193]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [198]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [199]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [200]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [201]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [202]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [203]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [204]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [205]
Methotrexate DM2TEOL Anterior urethra cancer Approved [198]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Keratin, type II cytoskeletal 8 (KRT8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [206]
Selenium DM25CGV N. A. N. A. Approved [128]
Methotrexate DM2TEOL Anterior urethra cancer Approved [207]
Quercetin DM3NC4M Obesity 5B81 Approved [208]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [206]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [209]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [210]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Growth-regulated alpha protein (CXCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [211]
Selenium DM25CGV N. A. N. A. Approved [212]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [126]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [213]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [198]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [213]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [214]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [198]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [184]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [215]
Testosterone DM7HUNW Hot flushes GA30 Approved [216]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [217]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcriptional activator Myb (MYB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [218]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [219]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [220]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [221]
Estrone DM5T6US Acne vulgaris ED80 Approved [218]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [222]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [223]
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Osteopontin (SPP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [224]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [114]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [116]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [225]
Quercetin DM3NC4M Obesity 5B81 Approved [226]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [227]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [228]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [230]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [231]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [232]
Etretinate DM2CZFA Keratosis ED56 Approved [233]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [234]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [235]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [236]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [237]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [238]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [239]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [240]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [241]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [242]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [241]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [241]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Fluoxetine DM3PD2C Bipolar depression Approved [241]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [243]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Creatine kinase B-type (CKB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [114]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Selenium DM25CGV N. A. N. A. Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [213]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [213]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [244]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [245]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [206]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [246]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [247]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [248]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [249]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [250]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [251]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein Hox-B2 (HOXB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [187]
Folic Acid DMEMBJC Colorectal carcinoma Approved [252]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [174]
Topotecan DMP6G8T Central nervous system neoplasm Approved [168]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [253]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [254]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [177]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [255]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fos-related antigen 2 (FOSL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [73]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [141]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [141]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [256]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [257]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [258]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [259]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [260]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [261]
Dacarbazine DMNPZL4 Adenocarcinoma 2D40 Approved [262]
Topotecan DMP6G8T Central nervous system neoplasm Approved [263]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [264]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [265]
Quercetin DM3NC4M Obesity 5B81 Approved [266]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [267]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Early growth response protein 1 (EGR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [182]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [193]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [268]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [269]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [270]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [271]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [190]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [272]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [182]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [193]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [273]
Methotrexate DM2TEOL Anterior urethra cancer Approved [274]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [275]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [276]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [120]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [159]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-X-C motif chemokine 2 (CXCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Selenium DM25CGV N. A. N. A. Approved [212]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [198]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [277]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [278]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [279]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-X-C motif chemokine 3 (CXCL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [202]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [198]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [280]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [133]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endothelin-2 (EDN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [184]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [130]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [282]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [283]
Arsenic DMTL2Y1 N. A. N. A. Approved [284]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [285]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [286]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Methotrexate DM2TEOL Anterior urethra cancer Approved [109]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [286]
Ethacrynic acid DM60QMR Edema MG29 Approved [287]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [288]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [289]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [286]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Diamine acetyltransferase 1 (SAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Selenium DM25CGV N. A. N. A. Approved [128]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [290]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [291]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [291]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [292]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [187]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [293]
Quercetin DM3NC4M Obesity 5B81 Approved [294]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [269]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [270]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [213]
Bupivacaine DM4PRFC Anaesthesia 9A78.6 Approved [295]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [213]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [296]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [297]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [107]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [298]
Gefitinib DM15F0X Colon adenocarcinoma Approved [90]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [299]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [300]
Selenium DM25CGV N. A. N. A. Approved [128]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [301]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [302]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 5 (CD40)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [303]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [304]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [245]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [305]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [303]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [148]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [306]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myristoylated alanine-rich C-kinase substrate (MARCKS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [128]
Methotrexate DM2TEOL Anterior urethra cancer Approved [198]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [198]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [257]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [209]
Testosterone DM7HUNW Hot flushes GA30 Approved [55]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Testosterone enanthate DMB6871 N. A. N. A. Approved [163]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein EVI2B (EVI2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [221]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [140]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [221]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [167]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [307]
Testosterone undecanoate DMZO10Y Hypogonadism 5A61.0 Approved [308]
PMID28870136-Compound-48 DMPIM9L N. A. N. A. Patented [309]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [310]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [148]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Heat shock 70 kDa protein 1-like (HSPA1L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [311]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [312]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [269]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [270]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [272]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Isoproterenol DMK7MEY Atrioventricular block Approved [313]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Teriflunomide DMQ2FKJ Hyperlipidaemia 5C80 Approved [314]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutaredoxin-1 (GLRX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [193]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [184]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [315]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [134]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [316]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [317]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [318]
Gefitinib DM15F0X Colon adenocarcinoma Approved [319]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [299]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [193]
Etretinate DM2CZFA Keratosis ED56 Approved [320]
Prednisone DM2HG4X Acute asthma CA23 Approved [321]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [322]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [81]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nicotinamide N-methyltransferase (NNMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [279]
Testosterone enanthate DMB6871 N. A. N. A. Approved [163]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [323]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [324]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Benzatropine DMF7EXL Parkinsonian disorder Approved [325]
Clozapine DMFC71L Schizophrenia 6A20 Approved [325]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [326]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [327]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [328]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By B-cell lymphoma 6 protein (BCL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [267]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [267]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [267]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [329]
Bortezomib DMNO38U Leukemia Approved [330]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Regulator of G-protein signaling 2 (RGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [275]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [331]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [130]
Testosterone DM7HUNW Hot flushes GA30 Approved [55]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [332]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [279]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Leukemia inhibitory factor receptor (LIFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [126]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [333]
Gentamicin DMKINJO Bacteremia 1A73 Approved [334]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Melanoma-associated antigen 10 (MAGEA10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [335]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [254]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [336]
Drug(s) Affected By Lysophosphatidic acid receptor 6 (LPAR6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [186]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Testosterone enanthate DMB6871 N. A. N. A. Approved [163]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [315]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [337]
Arsenic DMTL2Y1 N. A. N. A. Approved [172]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras GTPase-activating-like protein IQGAP1 (IQGAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [338]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [339]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [340]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Folic Acid DMEMBJC Colorectal carcinoma Approved [252]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinaldehyde dehydrogenase 3 (ALDH1A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [102]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [341]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [72]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [130]
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [74]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [141]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [141]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Max-interacting protein 1 (MXI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [342]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [141]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [141]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [141]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [148]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [274]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [329]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ETS translocation variant 1 (ETV1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [285]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [343]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [189]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [131]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [174]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [256]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [256]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [344]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glypican-3 (GPC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [345]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [346]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [133]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [122]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [131]
Methotrexate DM2TEOL Anterior urethra cancer Approved [347]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription initiation factor IIA subunit 1 (GTF2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [348]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [349]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Folic Acid DMEMBJC Colorectal carcinoma Approved [252]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Arsenic DMTL2Y1 N. A. N. A. Approved [172]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [285]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [173]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [176]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Growth arrest-specific protein 1 (GAS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [72]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [184]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [280]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [350]
Arsenic DMTL2Y1 N. A. N. A. Approved [351]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [352]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [328]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Puromycin-sensitive aminopeptidase (NPEPPS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [273]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Testosterone enanthate DMB6871 N. A. N. A. Approved [163]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [340]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [131]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [50]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Methionine--tRNA ligase, cytoplasmic (MARS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [353]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [285]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [354]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [189]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [173]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [131]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [355]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [157]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [356]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [357]
Quercetin DM3NC4M Obesity 5B81 Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [358]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [359]
Testosterone DM7HUNW Hot flushes GA30 Approved [55]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras-related protein Rab-8A (RAB8A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [342]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [353]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [285]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [360]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [189]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [361]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lysozyme C (LYZ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [186]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [362]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [363]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [315]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [364]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transforming growth factor beta-2 proprotein (TGFB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [365]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [129]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [366]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [367]
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [332]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [279]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [346]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Large ribosomal subunit protein eL37 (RPL37)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [368]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [369]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [173]
Urethane DM7NSI0 N. A. N. A. Phase 4 [144]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [176]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [177]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [370]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [371]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H4 (H4C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [193]
Selenium DM25CGV N. A. N. A. Approved [128]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [273]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Panobinostat DM58WKG Chronic graft versus host disease Approved [372]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [183]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 20 (CCL20)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [202]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [211]
Methotrexate DM2TEOL Anterior urethra cancer Approved [198]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [198]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [374]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ADP-ribosylation factor 1 (ARF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [375]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [376]
Arsenic DMTL2Y1 N. A. N. A. Approved [172]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [256]
Josamycin DMKJ8LB Bacterial infection 1A00-1C4Z Approved [377]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor NF-kappa-B p100 subunit (NFKB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [94]
Methotrexate DM2TEOL Anterior urethra cancer Approved [378]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [129]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [379]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [380]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [381]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase , mitochondrial (ALDH6A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [382]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [159]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [288]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [159]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [383]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pro-neuregulin-1, membrane-bound isoform (NRG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [68]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [157]
Methotrexate DM2TEOL Anterior urethra cancer Approved [378]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [190]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [183]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [384]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [385]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [386]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Bortezomib DMNO38U Leukemia Approved [330]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [50]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [327]
Chondroitin sulfate DM0N19Y N. A. N. A. Phase 4 [387]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [388]
Calcidiol DMN4CV5 Hypophosphatemia Approved [389]
Calcipotriol DM03CP7 Psoriasis EA90 Approved [390]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [391]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [392]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [393]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [394]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [395]
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent RNA helicase A (DHX9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [196]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [134]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [50]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [396]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [353]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear cap-binding protein subunit 1 (NCBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Benzatropine DMF7EXL Parkinsonian disorder Approved [325]
Clozapine DMFC71L Schizophrenia 6A20 Approved [325]
Urethane DM7NSI0 N. A. N. A. Phase 4 [144]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [397]
PP-242 DM2348V Discovery agent N.A. Investigative [398]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TP53-binding protein 1 (TP53BP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [146]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [164]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [399]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [234]
Arsenic DMTL2Y1 N. A. N. A. Approved [400]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [401]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [189]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [173]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ankyrin-3 (ANK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [206]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [157]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [402]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Testosterone enanthate DMB6871 N. A. N. A. Approved [163]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [329]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [50]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [181]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TNF receptor-associated factor 1 (TRAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [403]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [404]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [280]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [148]
Folic Acid DMEMBJC Colorectal carcinoma Approved [405]
Menthol DMG2KW7 Back pain ME84.Z Approved [406]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By PDZK1-interacting protein 1 (PDZK1IP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [120]
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [346]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [337]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [285]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Treacle protein (TCOF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [325]
Quercetin DM3NC4M Obesity 5B81 Approved [146]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [392]
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Testosterone enanthate DMB6871 N. A. N. A. Approved [163]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [50]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [407]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [408]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [157]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [409]
Methotrexate DM2TEOL Anterior urethra cancer Approved [378]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [129]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [267]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [385]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [407]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [408]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [410]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [411]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [154]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [412]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [413]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [289]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [414]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [157]
Selenium DM25CGV N. A. N. A. Approved [128]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [416]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [376]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [50]
Arsenic DMTL2Y1 N. A. N. A. Approved [172]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [189]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Enhancer of filamentation 1 (NEDD9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [213]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [213]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [141]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [141]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [141]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [141]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon regulatory factor 3 (IRF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [130]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Hydroxychloroquine DMSIVND Chronic renal failure GB61.Z Approved [417]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [327]
Diphenylpyraline DMW4X37 Allergic rhinitis CA08.0 Approved [418]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [397]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By FXYD domain-containing ion transport regulator 3 (FXYD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [419]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [73]
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [164]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [420]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [337]
Raltitrexed DMT9K8G Rectal adenocarcinoma 2B92 Approved [420]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [181]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [420]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ankyrin repeat domain-containing protein 1 (ANKRD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [279]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Ethanol DMDRQZU Chronic pain MG30 Approved [421]
Folic Acid DMEMBJC Colorectal carcinoma Approved [422]
Ampicillin DMHWE7P Acute epiglottitis Approved [51]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Disks large homolog 2 (DLG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [325]
Haloperidol DM96SE0 Delirium Approved [325]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [279]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [386]
Benzatropine DMF7EXL Parkinsonian disorder Approved [325]
Clozapine DMFC71L Schizophrenia 6A20 Approved [325]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [423]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [178]
Urethane DM7NSI0 N. A. N. A. Phase 4 [144]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [176]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cysteine and glycine-rich protein 2 (CSRP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [277]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [184]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [346]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-G2 (CCNG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [218]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Fluoxetine DM3PD2C Bipolar depression Approved [267]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Estrone DM5T6US Acne vulgaris ED80 Approved [218]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [141]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [141]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Golgi-associated kinase 1B (GASK1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [157]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [184]
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [326]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By SUZ domain-containing protein 1 (SZRD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [129]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [352]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [173]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [71]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [176]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Leucine-rich repeat-containing protein 28 (LRRC28)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [73]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [424]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [337]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [189]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [173]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [425]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [253]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitochondrial basic amino acids transporter (SLC25A29)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Testosterone DM7HUNW Hot flushes GA30 Approved [55]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
Arsenic DMTL2Y1 N. A. N. A. Approved [172]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [426]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [427]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [428]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [176]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Equilibrative nucleobase transporter 1 (SLC43A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [392]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [198]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [279]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
Bortezomib DMNO38U Leukemia Approved [330]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [198]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [429]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proprotein convertase subtilisin/kexin type 9 (PCSK9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [120]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [72]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [430]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [346]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [431]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [364]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase RNF149 (RNF149)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
Arsenic DMTL2Y1 N. A. N. A. Approved [432]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [433]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [176]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [177]
Milchsaure DM462BT Pruritus EC90 Investigative [147]
methyl p-hydroxybenzoate DMO58UW Discovery agent N.A. Investigative [434]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By F-box only protein 25 (FBXO25)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [285]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [189]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [174]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [254]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [435]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 14 (SLC2A14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [240]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [436]
Testosterone DM7HUNW Hot flushes GA30 Approved [55]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [74]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Testosterone enanthate DMB6871 N. A. N. A. Approved [163]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [437]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [337]
Vandetanib DMRICNP Solid tumour/cancer 2A00-2F9Z Approved [438]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Membrane progestin receptor beta (PAQR8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [157]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [130]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [346]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [13]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 4 group A member 3 (NR4A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [102]
Methotrexate DM2TEOL Anterior urethra cancer Approved [198]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [198]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [140]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [187]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [133]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [198]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [350]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By La-related protein 4B (LARP4B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [128]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [439]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [376]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [440]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [189]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [168]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [128]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen triple helix repeat-containing protein 1 (CTHRC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Testosterone DM7HUNW Hot flushes GA30 Approved [55]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [280]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [324]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [424]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [424]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [189]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BTB/POZ domain-containing protein KCTD12 (KCTD12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [54]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [402]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Ethanol DMDRQZU Chronic pain MG30 Approved [421]
Benzatropine DMF7EXL Parkinsonian disorder Approved [325]
Clozapine DMFC71L Schizophrenia 6A20 Approved [325]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [157]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [279]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [441]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [337]
Arsenic DMTL2Y1 N. A. N. A. Approved [172]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [327]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sialidase-1 (NEU1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [273]
Fluoxetine DM3PD2C Bipolar depression Approved [137]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Panobinostat DM58WKG Chronic graft versus host disease Approved [274]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [376]
Arsenic DMTL2Y1 N. A. N. A. Approved [172]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [352]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [189]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Galactosylceramide sulfotransferase (GAL3ST1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [337]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [50]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [181]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [167]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [174]
Fenretinide DMRD5SP Macular degeneration 9B78.3 Phase 3 [442]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Junctional adhesion molecule C (JAM3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [131]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [443]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [174]
Urethane DM7NSI0 N. A. N. A. Phase 4 [144]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [176]
3R14S-OCHRATOXIN A DM2KEW6 Discovery agent N.A. Investigative [444]
Methyl Mercury Ion DM6YEW4 Discovery agent N.A. Investigative [444]
Tributylstannanyl DMHN7CB Discovery agent N.A. Investigative [444]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By SLIT and NTRK-like protein 2 (SLITRK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Folic Acid DMEMBJC Colorectal carcinoma Approved [252]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [176]
Drug(s) Affected By Anaphase-promoting complex subunit 1 (ANAPC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [152]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [445]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [50]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [446]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [189]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [447]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [448]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Anthrax toxin receptor 1 (ANTXR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [198]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [198]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [183]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [130]
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [164]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [326]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras-related GTP-binding protein D (RRAGD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Capsaicin DMGMF6V Back pain ME84.Z Approved [449]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [424]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [189]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [433]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [182]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [450]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [451]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [159]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [183]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [452]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Intersectin-2 (ITSN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [146]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [453]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [327]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [446]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [173]
Urethane DM7NSI0 N. A. N. A. Phase 4 [144]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [176]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Probable ribosome biogenesis protein RLP24 (RSL24D1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [352]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [177]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [454]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [435]
chloropicrin DMSGBQA Discovery agent N.A. Investigative [455]
Deguelin DMXT7WG Esophageal squamous cell carcinoma 2E60.1 Investigative [456]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription elongation factor A protein-like 9 (TCEAL9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [457]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [446]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [189]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [173]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [176]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [177]
chloropicrin DMSGBQA Discovery agent N.A. Investigative [455]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone deacetylase 9 (HDAC9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [157]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Panobinostat DM58WKG Chronic graft versus host disease Approved [458]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [184]
Pirfenidone DM6VZFQ Idiopathic pulmonary fibrosis CB03.4 Approved [458]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [381]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [148]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [346]
Indomethacin DMSC4A7 Bursitis Approved [459]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [285]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphoserine aminotransferase (PSAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [182]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [392]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [277]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [182]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [141]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [141]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [381]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Chloride intracellular channel protein 4 (CLIC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [129]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [460]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [182]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Testosterone enanthate DMB6871 N. A. N. A. Approved [163]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Clozapine DMFC71L Schizophrenia 6A20 Approved [325]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-2-macroglobulin (A2M)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [461]
Prednisone DM2HG4X Acute asthma CA23 Approved [462]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [129]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [244]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [244]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [463]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Aminocaproic Acid DMFGND4 Bleeding disorder GA20-GA21 Approved [462]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pro-epidermal growth factor (EGF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [464]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [465]
Quercetin DM3NC4M Obesity 5B81 Approved [98]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [194]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [466]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [467]
Testosterone DM7HUNW Hot flushes GA30 Approved [55]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin (INS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [468]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
Epinephrine DM3KJBC Acute asthma CA23 Approved [469]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [470]
Fructose DM43AN2 Vomiting MD90 Approved [471]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [472]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [473]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [474]
Propranolol DM79NTF Angina pectoris BA40 Approved [475]
Testosterone DM7HUNW Hot flushes GA30 Approved [476]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lymphotoxin-alpha (LTA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [269]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [148]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [337]
Arsenic DMTL2Y1 N. A. N. A. Approved [477]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [479]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [480]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [480]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [481]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [482]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [483]
Fructose DM43AN2 Vomiting MD90 Approved [102]
Ketoprofen DMRKXPT Bursitis Approved [102]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [484]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [485]
Gefitinib DM15F0X Colon adenocarcinoma Approved [486]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [487]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [203]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon gamma (IFNG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [181]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [488]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [489]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [490]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [491]
Quercetin DM3NC4M Obesity 5B81 Approved [492]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [493]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [494]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [495]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-1 alpha (IL1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [496]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [496]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [203]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [496]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
Quercetin DM3NC4M Obesity 5B81 Approved [497]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [496]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [269]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [202]
Gefitinib DM15F0X Colon adenocarcinoma Approved [498]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [496]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [499]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [496]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [204]
Selenium DM25CGV N. A. N. A. Approved [212]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [500]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [501]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serum amyloid P-component (APCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [120]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valsartan DMREUQ6 Chronic heart failure BD1Z Approved [502]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [503]
Arsenic DMTL2Y1 N. A. N. A. Approved [172]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [285]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [78]
Ardeparin DMYRX8B Deep vein thrombosis BD71 Approved [504]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [176]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Beta-2-glycoprotein 1 (APOH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Olanzapine DMPFN6Y Bipolar depression Approved [505]
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [506]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [507]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [337]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [50]
Arsenic DMTL2Y1 N. A. N. A. Approved [172]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-fetoprotein (AFP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [229]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [508]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [509]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [229]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [510]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [511]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [512]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [513]
Quercetin DM3NC4M Obesity 5B81 Approved [514]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [269]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [515]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [516]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [517]
Testosterone DM7HUNW Hot flushes GA30 Approved [55]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [518]
Acetylcholine DMDF79Z Cataract 9B10 Approved [519]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [520]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-4 (IL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [521]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [522]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [523]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [524]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [525]
Prednisone DM2HG4X Acute asthma CA23 Approved [526]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [490]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [491]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [527]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myeloperoxidase (MPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dapsone DM4LT8A Acne vulgaris ED80 Approved [102]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [376]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [102]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [102]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [528]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [529]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [530]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [531]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [532]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [533]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endothelin-1 (EDN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [534]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [279]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [535]
Methotrexate DM2TEOL Anterior urethra cancer Approved [378]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [536]
Quercetin DM3NC4M Obesity 5B81 Approved [537]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [158]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [538]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [539]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [540]
Dicloxacillin DM8EU0Z Bacterial infection 1A00-1C4Z Approved [540]
Ergonovine DM0VEC1 Postpartum haemorrhage JA43 Approved [102]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [541]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [542]
Mizolastine DM1FDN8 Allergic rhinitis CA08.0 Approved [543]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [513]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [544]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [545]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [546]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stromelysin-1 (MMP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [102]
Fluvastatin DM4MDJY Arteriosclerosis BD40 Approved [102]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [102]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [102]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [211]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [547]
Methotrexate DM2TEOL Anterior urethra cancer Approved [548]
Quercetin DM3NC4M Obesity 5B81 Approved [549]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [550]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Coagulation factor VII (F7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Mestranol DMG3F94 Contraception QA21 Approved [551]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [120]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [552]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [553]
Morphine DMRMS0L Advanced cancer 2A00-2F9Z Approved [554]
Cenestin DMXQS7K Menopause symptom GA30.0 Approved [555]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibroblast growth factor 2 (FGF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [556]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [317]
Diazepam DM08E9O Alcohol withdrawal Approved [557]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [558]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [559]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [560]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [183]
Isradipine DMA5XGH Hypertension BA00-BA04 Approved [561]
Valdecoxib DMAY7H4 Osteoarthritis FA00-FA05 Approved [562]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Granulocyte colony-stimulating factor (CSF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [202]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [211]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [563]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [564]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [516]
Ethanol DMDRQZU Chronic pain MG30 Approved [565]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [566]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [198]
Pomalidomide DMTGBAX Plasma cell myeloma 2A83.1 Approved [567]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [568]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [569]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [570]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [200]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [571]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [202]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [496]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [499]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [572]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [496]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 3 (CCL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [201]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [269]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [270]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [573]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [277]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [574]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [575]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [575]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [201]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [201]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [114]
Gefitinib DM15F0X Colon adenocarcinoma Approved [576]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [203]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [522]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [215]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [546]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [577]
Quercetin DM3NC4M Obesity 5B81 Approved [578]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prostatic acid phosphatase (ACP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [579]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [130]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [580]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [457]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [346]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
Arsenic DMTL2Y1 N. A. N. A. Approved [172]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [285]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kit ligand (KITLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [68]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
Quercetin DM3NC4M Obesity 5B81 Approved [497]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [402]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [581]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [457]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-10 (IL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [513]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [488]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [524]
Methotrexate DM2TEOL Anterior urethra cancer Approved [582]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [583]
Quercetin DM3NC4M Obesity 5B81 Approved [584]
Bisoprolol DM3UZ95 Hypertension BA00-BA04 Approved [585]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [493]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [214]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [586]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Haloperidol DM96SE0 Delirium Approved [587]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [114]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [588]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Bupivacaine DM4PRFC Anaesthesia 9A78.6 Approved [589]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [590]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [130]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [279]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD40 ligand (CD40LG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [203]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [304]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [591]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [592]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [593]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [594]
Menthol DMG2KW7 Back pain ME84.Z Approved [406]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [595]
Eptifibatide DMQXTJS Acute cardiac ischemic events BA40.Z Approved [596]
Candesartan DMRK8OT Chronic heart failure BD1Z Approved [594]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-13 (IL13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [597]
Prednisone DM2HG4X Acute asthma CA23 Approved [598]
Methotrexate DM2TEOL Anterior urethra cancer Approved [599]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [564]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [495]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [600]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Budesonide DMJIBAW Allergic rhinitis CA08.0 Approved [601]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [564]
Ethambutol DMR87LC Pulmonary tuberculosis 1B10.Z Approved [495]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thrombopoietin (THPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [602]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Methamphetamine DMPM4SK Anxiety Approved [603]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [285]
Testosterone undecanoate DMZO10Y Hypogonadism 5A61.0 Approved [308]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [174]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [102]
Urethane DM7NSI0 N. A. N. A. Phase 4 [144]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [173]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-15 (IL15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [515]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [164]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [148]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [566]
Bortezomib DMNO38U Leukemia Approved [330]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Leptin (LEP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [201]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [203]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [604]
Quercetin DM3NC4M Obesity 5B81 Approved [605]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [606]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [201]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [201]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [607]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [608]
Amlodipine DMBDAZV Angina pectoris BA40 Approved [609]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pappalysin-1 (PAPPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [183]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [280]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [187]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [346]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [133]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [610]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [611]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pro-interleukin-16 (IL16)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [612]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [280]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Ethanol DMDRQZU Chronic pain MG30 Approved [565]
Menthol DMG2KW7 Back pain ME84.Z Approved [406]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [613]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [350]
Arsenic DMTL2Y1 N. A. N. A. Approved [614]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adiponectin (ADIPOQ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [201]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [201]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [615]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [563]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [201]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [616]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [617]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [201]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [607]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [618]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldehyde dehydrogenase 1A1 (ALDH1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [619]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [620]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [257]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [379]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [621]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [622]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [623]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [624]
Propranolol DM79NTF Angina pectoris BA40 Approved [625]
Testosterone DM7HUNW Hot flushes GA30 Approved [55]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [626]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [627]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
Mebendazole DMO14SG Ascariasis 1F62 Approved [628]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proto-oncogene c-Rel (REL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [629]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [411]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [630]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [187]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [148]
Norepinephrine DMOUC09 Alopecia ED70 Approved [631]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [181]
Arsenic DMTL2Y1 N. A. N. A. Approved [614]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [632]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [188]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Telomerase reverse transcriptase (TERT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [633]
Gefitinib DM15F0X Colon adenocarcinoma Approved [634]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [402]
Selenium DM25CGV N. A. N. A. Approved [635]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [636]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [637]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [638]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [639]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [640]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [641]
Gefitinib DM15F0X Colon adenocarcinoma Approved [319]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [642]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [409]
Etretinate DM2CZFA Keratosis ED56 Approved [320]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [273]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [643]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [644]
Quercetin DM3NC4M Obesity 5B81 Approved [645]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [646]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear protein 1 (NUPR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [241]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [647]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [242]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [241]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [241]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Fluoxetine DM3PD2C Bipolar depression Approved [241]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [392]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [647]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [102]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [224]
Diazepam DM08E9O Alcohol withdrawal Approved [557]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [206]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [648]
Methotrexate DM2TEOL Anterior urethra cancer Approved [450]
Ceruletide DM2WE5K Caerulein stimulated gastric and pancreatic secretion 5A4Y Approved [649]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [650]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [651]
Quercetin DM3NC4M Obesity 5B81 Approved [652]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [653]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [654]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [655]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [656]
Paclitaxel DMLB81S Breast carcinoma Approved [657]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [658]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [355]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [659]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [660]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [661]
Gefitinib DM15F0X Colon adenocarcinoma Approved [662]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [508]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [663]
Quercetin DM3NC4M Obesity 5B81 Approved [226]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [664]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [453]
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [74]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [141]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [665]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [182]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [200]
Verapamil DMA7PEW Angina pectoris BA40 Approved [666]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [202]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [629]
Selenium DM25CGV N. A. N. A. Approved [667]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [546]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [668]
Methotrexate DM2TEOL Anterior urethra cancer Approved [378]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Gefitinib DM15F0X Colon adenocarcinoma Approved [669]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [670]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [409]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [671]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [322]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [671]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [672]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [673]
Methotrexate DM2TEOL Anterior urethra cancer Approved [674]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Zinc finger protein GLI2 (GLI2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [675]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [676]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [677]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [130]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [133]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [678]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Clusterin (CLU)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [679]
Selenium DM25CGV N. A. N. A. Approved [128]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [679]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [126]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [680]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [183]
Testosterone DM7HUNW Hot flushes GA30 Approved [55]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [679]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [68]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [681]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [318]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Selenium DM25CGV N. A. N. A. Approved [682]
Etretinate DM2CZFA Keratosis ED56 Approved [320]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [322]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [683]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [273]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase B-raf (BRAF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [684]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [379]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [685]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [441]
Famotidine DMRL3AB Gastric ulcer DA60 Approved [686]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [687]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [141]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [688]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [240]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [499]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [689]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [690]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [691]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [692]
Quercetin DM3NC4M Obesity 5B81 Approved [693]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [126]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD44 antigen (CD44)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [218]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Selenium DM25CGV N. A. N. A. Approved [694]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [619]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [695]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [53]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [412]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [696]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [697]
Selenium DM25CGV N. A. N. A. Approved [128]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [698]
Etretinate DM2CZFA Keratosis ED56 Approved [699]
Methotrexate DM2TEOL Anterior urethra cancer Approved [700]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [701]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [702]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [703]
Quercetin DM3NC4M Obesity 5B81 Approved [704]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor-binding protein 3 (IGFBP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [157]
Selenium DM25CGV N. A. N. A. Approved [461]
Methotrexate DM2TEOL Anterior urethra cancer Approved [450]
Quercetin DM3NC4M Obesity 5B81 Approved [705]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [213]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [228]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [304]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [706]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cannabinoid receptor 1 (CNR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [707]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Menthol DMG2KW7 Back pain ME84.Z Approved [406]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [133]
Norepinephrine DMOUC09 Alopecia ED70 Approved [708]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [709]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [337]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [206]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [193]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [409]
Methotrexate DM2TEOL Anterior urethra cancer Approved [710]
Epinephrine DM3KJBC Acute asthma CA23 Approved [711]
Quercetin DM3NC4M Obesity 5B81 Approved [226]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [712]
Fructose DM43AN2 Vomiting MD90 Approved [713]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [206]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [267]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [714]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [715]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [716]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [717]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [718]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [719]
Gefitinib DM15F0X Colon adenocarcinoma Approved [720]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [721]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [722]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aryl hydrocarbon receptor nuclear translocator (ARNT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [723]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [724]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [725]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [726]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [441]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [188]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [189]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [441]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [727]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [715]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [728]
Paclitaxel DMLB81S Breast carcinoma Approved [729]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [730]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [714]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [102]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [717]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 14-3-3 protein sigma (SFN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [68]
Gefitinib DM15F0X Colon adenocarcinoma Approved [731]
Methotrexate DM2TEOL Anterior urethra cancer Approved [450]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [190]
Quercetin DM3NC4M Obesity 5B81 Approved [732]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [129]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [190]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [229]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [733]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cannabinoid receptor 2 (CNR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Guanfacine extended release DMB1CZ8 Attention deficit hyperactivity disorder 6A05.Z Approved [734]
NABILONE DMVRYT2 Insomnia 7A00-7A0Z Approved [735]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [736]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [737]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [738]
Menthol DMG2KW7 Back pain ME84.Z Approved [406]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [709]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [181]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [167]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [739]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [740]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [741]
Quercetin DM3NC4M Obesity 5B81 Approved [226]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [742]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [743]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [744]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [745]
Testosterone DM7HUNW Hot flushes GA30 Approved [746]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [747]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [298]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [748]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [749]
Methotrexate DM2TEOL Anterior urethra cancer Approved [378]
Quercetin DM3NC4M Obesity 5B81 Approved [268]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [238]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [102]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [750]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [751]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [752]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [753]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [754]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [755]
Quercetin DM3NC4M Obesity 5B81 Approved [756]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [757]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [758]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [759]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [656]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [760]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [761]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [762]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [763]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [764]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [408]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [765]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [146]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [392]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [153]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [510]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [766]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [767]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [130]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [128]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [129]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [379]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [768]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor SOX-2 (SOX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [200]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [619]
Quercetin DM3NC4M Obesity 5B81 Approved [769]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [412]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [770]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [184]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [771]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [230]
Gefitinib DM15F0X Colon adenocarcinoma Approved [772]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [773]
Selenium DM25CGV N. A. N. A. Approved [128]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [774]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [775]
Quercetin DM3NC4M Obesity 5B81 Approved [497]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [776]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [777]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [582]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [129]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [72]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [332]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [768]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase PLK1 (PLK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [68]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [193]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [392]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [778]
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [74]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [779]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [780]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [105]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [781]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [782]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [409]
Meloxicam DM2AR7L Arthritis FA20 Approved [783]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [784]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [785]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BH3-interacting domain death agonist (BID)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [409]
Selenium DM25CGV N. A. N. A. Approved [85]
Quercetin DM3NC4M Obesity 5B81 Approved [497]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [129]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [786]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [787]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [788]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [206]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [198]
Quercetin DM3NC4M Obesity 5B81 Approved [226]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [725]
Carfilzomib DM48K0X Multiple myeloma 2A83 Approved [696]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [198]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [789]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [790]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Flucytosine DM13VTW Cryptococcal meningitis Approved [108]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [108]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [791]
Methotrexate DM2TEOL Anterior urethra cancer Approved [378]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [792]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [654]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [159]
Amifostine DM5FL14 Mucositis CA00 Approved [793]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [619]
Quercetin DM3NC4M Obesity 5B81 Approved [794]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [243]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [412]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [345]
Testosterone DM7HUNW Hot flushes GA30 Approved [795]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [796]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [797]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [107]
Selenium DM25CGV N. A. N. A. Approved [128]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [749]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [530]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [798]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [799]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [800]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Regenerating islet-derived protein 3-alpha (REG3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [346]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [189]
Ethanol DMDRQZU Chronic pain MG30 Approved [102]
Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [355]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [801]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [409]
Selenium DM25CGV N. A. N. A. Approved [128]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [802]
Methotrexate DM2TEOL Anterior urethra cancer Approved [378]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [108]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [410]
Quercetin DM3NC4M Obesity 5B81 Approved [497]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [269]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein patched homolog 1 (PTCH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [114]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [676]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [677]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [130]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Ethanol DMDRQZU Chronic pain MG30 Approved [803]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [804]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [337]
Arsenic DMTL2Y1 N. A. N. A. Approved [172]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [805]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [806]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [807]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Gefitinib DM15F0X Colon adenocarcinoma Approved [808]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [809]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [409]
Selenium DM25CGV N. A. N. A. Approved [128]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [784]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sonic hedgehog protein (SHH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [675]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [810]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [677]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [811]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Folic Acid DMEMBJC Colorectal carcinoma Approved [252]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [810]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [337]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [327]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [812]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [813]
Verapamil DMA7PEW Angina pectoris BA40 Approved [666]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [94]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [499]
Selenium DM25CGV N. A. N. A. Approved [128]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [814]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [691]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [692]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [815]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor protein p53-inducible nuclear protein 1 (TP53INP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [378]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [385]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [452]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [141]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [141]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [141]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein smoothened (SMO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Quercetin DM3NC4M Obesity 5B81 Approved [675]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [676]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [816]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [133]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [337]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein NANOG (NANOG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [817]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [619]
Quercetin DM3NC4M Obesity 5B81 Approved [794]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [243]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [412]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [345]
Testosterone DM7HUNW Hot flushes GA30 Approved [795]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [771]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Axin-2 (AXIN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [379]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [818]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [819]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [820]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [821]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [157]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [822]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [183]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Focal adhesion kinase 1 (PTK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [718]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [823]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [275]
Quercetin DM3NC4M Obesity 5B81 Approved [824]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [684]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [825]
Testosterone DM7HUNW Hot flushes GA30 Approved [826]
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [827]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [279]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [828]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [829]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [355]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [107]
Gefitinib DM15F0X Colon adenocarcinoma Approved [830]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [831]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [832]
Selenium DM25CGV N. A. N. A. Approved [128]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [508]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [301]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Splicing factor 45 (RBM17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [325]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [833]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [50]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [189]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [834]
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [834]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [835]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [836]
Prednisone DM2HG4X Acute asthma CA23 Approved [837]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [837]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [838]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [839]
Epinephrine DM3KJBC Acute asthma CA23 Approved [840]
Quercetin DM3NC4M Obesity 5B81 Approved [226]
Fluoxetine DM3PD2C Bipolar depression Approved [137]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [841]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neuropilin-1 (NRP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [114]
Methotrexate DM2TEOL Anterior urethra cancer Approved [378]
Quercetin DM3NC4M Obesity 5B81 Approved [152]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [279]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [187]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Oxysterol-binding protein 2 (OSBP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Selenium DM25CGV N. A. N. A. Approved [128]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [364]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [424]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [424]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [352]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [842]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [189]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [843]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bosutinib DMTI8YE Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [844]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [845]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
Quercetin DM3NC4M Obesity 5B81 Approved [756]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [846]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [847]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [848]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [848]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Equilibrative nucleoside transporter 3 (SLC29A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [436]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [337]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [188]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [849]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [849]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Probable ATP-dependent RNA helicase DDX53 (DDX53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [176]
Drug(s) Affected By Amphiregulin (AREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [850]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [193]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [97]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [851]
Estrone DM5T6US Acne vulgaris ED80 Approved [218]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [510]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [130]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [852]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pyruvate kinase PKM (PKM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Selenium DM25CGV N. A. N. A. Approved [128]
Epinephrine DM3KJBC Acute asthma CA23 Approved [840]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [853]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [245]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [210]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [340]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Equilibrative nucleoside transporter 1 (SLC29A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [854]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [855]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [856]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [436]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [857]
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [51]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-protein kinase 3 (ALPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [279]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Arsenic DMTL2Y1 N. A. N. A. Approved [172]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [285]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [842]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [189]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [173]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [174]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor AP-2-alpha (TFAP2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [858]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [218]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [859]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [860]
Panobinostat DM58WKG Chronic graft versus host disease Approved [122]
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [858]
Testosterone DM7HUNW Hot flushes GA30 Approved [55]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [280]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [141]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [141]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Death-associated protein kinase 1 (DAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [740]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [861]
Menthol DMG2KW7 Back pain ME84.Z Approved [406]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [595]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [862]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome c oxidase subunit 3 (COX3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [863]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [186]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [381]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [864]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [865]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [189]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [866]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [867]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [868]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [869]
Gefitinib DM15F0X Colon adenocarcinoma Approved [90]
Prednisone DM2HG4X Acute asthma CA23 Approved [321]
Methotrexate DM2TEOL Anterior urethra cancer Approved [870]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [871]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [92]
Quercetin DM3NC4M Obesity 5B81 Approved [872]
Fluoxetine DM3PD2C Bipolar depression Approved [873]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [874]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [875]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trastuzumab DMZQOUX Breast cancer 2C60-2C65 Approved [102]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [876]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [877]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [878]
Gefitinib DM15F0X Colon adenocarcinoma Approved [879]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [740]
Selenium DM25CGV N. A. N. A. Approved [128]
Methotrexate DM2TEOL Anterior urethra cancer Approved [378]
Quercetin DM3NC4M Obesity 5B81 Approved [219]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [880]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [94]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [878]
Gefitinib DM15F0X Colon adenocarcinoma Approved [881]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [402]
Selenium DM25CGV N. A. N. A. Approved [682]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [301]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [151]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [882]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 3-phosphoinositide-dependent protein kinase 1 (PDPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [883]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [441]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [884]
Amiloride DMRTSGP Congestive heart failure BD10 Approved [885]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [352]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [441]
Paclitaxel DMLB81S Breast carcinoma Approved [16]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleophosmin (NPM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [76]
Etretinate DM2CZFA Keratosis ED56 Approved [233]
Methotrexate DM2TEOL Anterior urethra cancer Approved [207]
Quercetin DM3NC4M Obesity 5B81 Approved [338]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [886]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [74]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [340]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase SMG1 (SMG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Testosterone enanthate DMB6871 N. A. N. A. Approved [163]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [187]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [376]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [285]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [887]
Josamycin DMKJ8LB Bacterial infection 1A00-1C4Z Approved [377]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [887]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent DNA helicase PIF1 (PIF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [74]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [315]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [376]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [888]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [102]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [889]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [890]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [891]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [522]
Prednisone DM2HG4X Acute asthma CA23 Approved [892]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [893]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [894]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Olfactory receptor 4D6 (OR4D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic DMTL2Y1 N. A. N. A. Approved [172]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [176]
Drug(s) Affected By PDZ domain-containing protein GIPC1 (GIPC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [119]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [73]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [337]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [895]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [896]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [897]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [128]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin-linked protein kinase (ILK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [128]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [774]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [140]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [332]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [132]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [898]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [135]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 2 (PARP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [899]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [161]
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [74]
Leflunomide DMR8ONJ Arthritis FA20 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [148]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [376]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Ribonucleoside-diphosphate reductase M2 (RRM2) TTBWDI0 RIR2_HUMAN Modulator [5]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Concentrative nucleoside transporter 1 (SLC28A1) DT0EQPW S28A1_HUMAN Substrate [6]
Multidrug resistance-associated protein 5 (ABCC5) DTYVM24 MRP5_HUMAN Substrate [7]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [8]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytidine aminohydrolase (CDA) DEKEDRC CDD_HUMAN Substrate [9]
Cytidine deaminase (cdd) DETX3A5 CDD_ECOLI Substrate [10]
Cytidine deaminase (cdd) DEFVABT CDD_KLEP7 Substrate [10]
Uridine/cytidine monophosphate kinase (UMPK) DEMPH4I KCY_HUMAN Substrate [11]
Cytidine deaminase (cdd) DEYILK4 E0TLJ6_MYCHH Substrate [12]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1) OTG2T749 CP24A_HUMAN Gene/Protein Processing [13]
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2) OT5I4Y9K PLCB_HUMAN Gene/Protein Processing [13]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Post-Translational Modifications [14]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D) OT1RWFV0 PDE4D_HUMAN Drug Response [15]
3-phosphoinositide-dependent protein kinase 1 (PDPK1) OTT09ZVP PDPK1_HUMAN Drug Response [16]
5,6-dihydroxyindole-2-carboxylic acid oxidase OTRK49R4 TYRP1_HUMAN Gene/Protein Processing [13]
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Gene/Protein Processing [17]
ADP-ribosylation factor 1 (ARF1) OT5C4C3L ARF1_HUMAN Gene/Protein Processing [13]
Aldehyde dehydrogenase 1A1 (ALDH1A1) OTCUWZKB AL1A1_HUMAN Gene/Protein Processing [18]
Alpha-2-macroglobulin (A2M) OTFTX90K A2MG_HUMAN Gene/Protein Processing [17]

References

1 Gemcitabine FDA Label
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4793).
4 Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection. Antimicrob Agents Chemother. 2014 Aug;58(8):4885-93.
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6 Pancreatic Cancer Chemoresistance to Gemcitabine. Cancers (Basel). 2017 Nov 16;9(11).
7 Interdependence of gemcitabine treatment, transporter expression, and resistance in human pancreatic carcinoma cells. Neoplasia. 2010 Sep;12(9):740-7.
8 Increased sensitivity to gemcitabine of P-glycoprotein and multidrug resistance-associated protein-overexpressing human cancer cell lines. Br J Cancer. 2003 Jun 16;88(12):1963-70.
9 Equilibrative nucleoside transporter 1 genotype, cytidine deaminase activity and age predict gemcitabine plasma clearance in patients with solid tumours. Br J Clin Pharmacol. 2011 Mar;71(3):437-44.
10 Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science. 2017 Sep 15;357(6356):1156-1160.
11 Gemcitabine pharmacogenomics: deoxycytidine kinase and cytidylate kinase gene resequencing and functional genomics. Drug Metab Dispos. 2008 Sep;36(9):1951-9.
12 Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs. FEBS Open Bio. 2015 Aug 3;5:634-9.
13 Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
14 Reversible epigenetic regulation of 14-3-3 expression in acquired gemcitabine resistance by uhrf1 and DNA methyltransferase 1. Mol Pharmacol. 2014 Nov;86(5):561-9. doi: 10.1124/mol.114.092544. Epub 2014 Sep 4.
15 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Cancer Sci. 2013 Aug;104(8):1074-82. doi: 10.1111/cas.12186. Epub 2013 Jun 10.
16 Differential roles of phosphoinositide-dependent protein kinase-1 and akt1 expression and phosphorylation in breast cancer cell resistance to Paclitaxel, Doxorubicin, and gemcitabine. Mol Pharmacol. 2006 Sep;70(3):1045-52. doi: 10.1124/mol.106.023333. Epub 2006 Jun 16.
17 Metronomic gemcitabine suppresses tumour growth, improves perfusion, and reduces hypoxia in human pancreatic ductal adenocarcinoma. Br J Cancer. 2010 Jun 29;103(1):52-60.
18 Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate. Mol Ther. 2011 Jan;19(1):188-95.
19 Cellular pharmacology of gemcitabine. Ann Oncol. 2006 May;17 Suppl 5:v7-12.
20 PAN-811 inhibits oxidative stress-induced cell death of human Alzheimer's disease-derived and age-matched olfactory neuroepithelial cells via suppression of intracellular reactive oxygen species. J Alzheimers Dis. 2009;17(3):611-9.
21 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
22 Phase I study of oral gemcitabine prodrug (LY2334737) in Japanese patients with advanced solid tumors. Cancer Chemother Pharmacol. 2013 Jun;71(6):1645-55.
23 Gallium maltolate is a promising chemotherapeutic agent for the treatment of hepatocellular carcinoma. Anticancer Res. 2006 May-Jun;26(3A):1739-43.
24 Tezacitabine Hoechst Marion Roussel.Curr Opin Investig Drugs.2000 Sep;1(1):135-40.
25 Phase I and pharmacokinetic study of the oral tris-(8-quinolinolato)gallium(III) complex (FFC11, KP46) in patients with solid tumors - a study of the CESAR Central European Society for Anticancer Drug Research - EWIV. J Clin Oncol (Meeting Abstracts) June 2005 vol. 23 no. 16_suppl 3205.
26 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
27 MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
28 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
29 Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
30 Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
31 Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
32 Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
33 The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates. Cancer Res. 2005 May 15;65(10):4425-30.
34 ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44.
35 Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy. Curr Cancer Drug Targets. 2008 Aug;8(5):414-20.
36 Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine. Springerplus. 2014 Dec 13;3:732.
37 Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5). Drug Metab Rev. 2005;37(1):253-78.
38 Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP. J Biol Chem. 2007 Jul 20;282(29):20999-1004.
39 Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport. Eur J Pharm Sci. 2006 Apr;27(5):524-32.
40 Role of MRP4 and MRP5 in biology and chemotherapy. AAPS PharmSci. 2002;4(3):E14.
41 The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. J Biol Chem. 2000 Sep 29;275(39):30069-74.
42 FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia. Oncotarget. 2016 Aug 2;7(31):49786-49799.
43 Electrophysiological recordings of CNT1 (SLC28A1) activity on Nanions SURFE2R N1.
44 Lonsurf, INN-trifluridine/tipiracil.
45 Genetic factors influencing cytarabine therapy. Pharmacogenomics. 2009 Oct;10(10):1657-74.
46 Augmentation of the antitumor activity of capecitabine by a tumor selective dihydropyrimidine dehydrogenase inhibitor, RO0094889. Int J Cancer. 2003 Sep 20;106(5):799-805.
47 A pilot pharmacokinetic study of oral azacitidine. Leukemia. 2008 Sep;22(9):1680-4.
48 Tracking decitabine incorporation into malignant myeloid cell DNA in vitro and in vivo by LC-MS/MS with enzymatic digestion. Sci Rep. 2019 Mar 14;9(1):4558.
49 Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides. Cancer Res. 2007 Jul 1;67(13):6400-8. doi: 10.1158/0008-5472.CAN-07-0251.
50 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
51 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
52 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
53 Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer. Curr Pharm Des. 2013;19(5):940-50.
54 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
55 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
56 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
57 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
58 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
59 Characteristics of P388/VMDRC.04, a simple, sensitive model for studying P-glycoprotein antagonists. Cancer Res. 1994 Feb 1;54(3):730-7.
60 Michaelis-Menten kinetic analysis of drugs of abuse to estimate their affinity to human P-glycoprotein. Toxicol Lett. 2013 Feb 27;217(2):137-42. doi: 10.1016/j.toxlet.2012.12.012. Epub 2012 Dec 27.
61 Editor's Highlight: PlacentalDisposition and Effects of Crizotinib: An Ex Vivo Study in the Isolated Dual-Side Perfused Human Cotyledon. Toxicol Sci. 2017 Jun 1;157(2):500-509. doi: 10.1093/toxsci/kfx063.
62 Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs. Pharmacogenet Genomics. 2008 May;18(5):390-402. doi: 10.1097/FPC.0b013e3282f85e36.
63 Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells. Cancer Sci. 2005 Jun;96(6):372-6. doi: 10.1111/j.1349-7006.2005.00057.x.
64 Clinical pharmacokinetic monitoring of itraconazole is warranted in only a subset of patients. Ther Drug Monit. 2005 Jun;27(3):322-33. doi: 10.1097/01.ftd.0000150135.22645.ea.
65 Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein. Psychopharmacology (Berl). 2006 Sep;187(4):415-23. doi: 10.1007/s00213-006-0437-9. Epub 2006 Jun 30.
66 Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro. Haematologica. 2002 Feb;87(2):167-76.
67 Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells. Cancer Res. 1988 Sep 1;48(17):4926-32.
68 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
69 Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
70 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
71 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
72 Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
73 JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
74 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
75 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
76 Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
77 E2F1 downregulation by arsenic trioxide in lung adenocarcinoma. Int J Oncol. 2014 Nov;45(5):2033-43. doi: 10.3892/ijo.2014.2609. Epub 2014 Aug 19.
78 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
79 Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells. Mol Cancer Ther. 2012 Oct;11(10):2138-48. doi: 10.1158/1535-7163.MCT-12-0562. Epub 2012 Aug 6.
80 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
81 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
82 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
83 Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 2011 Mar;13(3):267-79. doi: 10.1093/neuonc/noq195. Epub 2011 Feb 3.
84 Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions. BMC Genomics. 2008 Aug 7;9:376.
85 Death receptor 5 regulation during selenium-mediated apoptosis in human prostate cancer cells. Cancer Biol Ther. 2002 May-Jun;1(3):287-90. doi: 10.4161/cbt.83.
86 Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J Natl Cancer Inst. 2004 Dec 1;96(23):1769-80. doi: 10.1093/jnci/djh322.
87 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
88 Induction of death receptor 5 and suppression of survivin contribute to sensitization of TRAIL-induced cytotoxicity by quercetin in non-small cell lung cancer cells. Carcinogenesis. 2007 Oct;28(10):2114-21. doi: 10.1093/carcin/bgm133. Epub 2007 Jun 4.
89 Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors. J Med Chem. 2011 Mar 10;54(5):1347-55. doi: 10.1021/jm101396q. Epub 2011 Feb 15.
90 Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
91 Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004 May 20;350(21):2129-39. doi: 10.1056/NEJMoa040938. Epub 2004 Apr 29.
92 The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res. 2005 Jan 1;65(1):18-25.
93 Prediction of chemosensitivity using multigene analysis in head and neck squamous cell carcinoma. Oncology. 2007;73(1-2):104-11. doi: 10.1159/000120998. Epub 2008 Mar 13.
94 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
95 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
96 Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
97 Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. Surgery. 2005 Sep;138(3):415-21. doi: 10.1016/j.surg.2005.06.030.
98 Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3). Cell Biochem Funct. 2011 Mar;29(2):87-95. doi: 10.1002/cbf.1725. Epub 2011 Feb 9.
99 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
100 Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
101 Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
102 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
103 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
104 Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
105 Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
106 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
107 -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
108 Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene. 2005 Feb 10;24(7):1231-43. doi: 10.1038/sj.onc.1208290.
109 Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
110 Synergistic antiproliferative effect of arsenic trioxide combined with bortezomib in HL60 cell line and primary blasts from patients affected by myeloproliferative disorders. Cancer Genet Cytogenet. 2010 Jun;199(2):110-20. doi: 10.1016/j.cancergencyto.2010.02.010.
111 A genomic approach to predict synergistic combinations for breast cancer treatment. Pharmacogenomics J. 2013 Feb;13(1):94-104. doi: 10.1038/tpj.2011.48. Epub 2011 Nov 15.
112 Efficacy and mechanism of action of the proteasome inhibitor PS-341 in T-cell lymphomas and HTLV-I associated adult T-cell leukemia/lymphoma. Oncogene. 2005 Jan 13;24(3):419-30. doi: 10.1038/sj.onc.1208212.
113 Identification of potential biomarkers of hepatitis B-induced acute liver failure using hepatic cells derived from human skin precursors. Toxicol In Vitro. 2015 Sep;29(6):1231-9. doi: 10.1016/j.tiv.2014.10.012. Epub 2014 Oct 24.
114 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
115 [Effect of nylestriol and levonorgestrel on the expression of Opg/OPGL in human osteosarcoma MG-63 cell lines]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Dec;29(6):667-70.
116 Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard. Arch Toxicol. 2021 Feb;95(2):727-747. doi: 10.1007/s00204-020-02946-5. Epub 2021 Jan 25.
117 Effects of disease-modifying antirheumatic drugs and antiinflammatory cytokines on human osteoclastogenesis through interaction with receptor activator of nuclear factor kappaB, osteoprotegerin, and receptor activator of nuclear factor kappaB ligand. Arthritis Rheum. 2004 Dec;50(12):3831-43. doi: 10.1002/art.20637.
118 [Effect of simvastatin on the function of MG63 cell line]. Shanghai Kou Qiang Yi Xue. 2010 Dec;19(6):658-62.
119 Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
120 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
121 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
122 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
123 Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
124 Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells. Neurosci Lett. 2006 Mar 13;395(3):185-90. doi: 10.1016/j.neulet.2005.10.096. Epub 2005 Dec 1.
125 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
126 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
127 Effects of four-week high-fructose diet on gene expression in skeletal muscle of healthy men. Diabetes Metab. 2008 Feb;34(1):82-5. doi: 10.1016/j.diabet.2007.08.004. Epub 2007 Dec 11.
128 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
129 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
130 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
131 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
132 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
133 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
134 Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
135 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
136 MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
137 Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
138 Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
139 Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
140 Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
141 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
142 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
143 Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells. Neoplasia. 2006 Sep;8(9):758-71.
144 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
145 Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 2013 Mar;3(3):308-23.
146 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
147 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
148 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
149 Expression and modulation of progesterone induced blocking factor (PIBF) and innate immune factors in human leukemia cell lines by progesterone and mifepristone. Leuk Lymphoma. 2007 Aug;48(8):1610-7. doi: 10.1080/10428190701471999.
150 Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates. Mol Cancer Ther. 2007 Mar;6(3):1031-8. doi: 10.1158/1535-7163.MCT-06-0643. Epub 2007 Mar 5.
151 Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
152 Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
153 An in vitro study on anti-carcinogenic effect of remdesivir in human ovarian cancer cells via generation of reactive oxygen species. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089257. doi: 10.1177/09603271221089257.
154 Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. doi: 10.1158/1535-7163.MCT-11-0934. Epub 2012 Jun 22.
155 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
156 Aspirin induces apoptosis in human leukemia cells independently of NF-kappaB and MAPKs through alteration of the Mcl-1/Noxa balance. Apoptosis. 2010 Feb;15(2):219-29. doi: 10.1007/s10495-009-0424-9.
157 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
158 Nucleoside reverse transcriptase inhibitors induce a mitophagy-associated endothelial cytotoxicity that is reversed by coenzyme Q10 cotreatment. Toxicol Sci. 2013 Aug;134(2):323-34. doi: 10.1093/toxsci/kft105. Epub 2013 May 2.
159 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
160 Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene. 2005 Feb 3;24(6):980-91. doi: 10.1038/sj.onc.1208095.
161 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
162 Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
163 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
164 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
165 Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
166 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
167 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
168 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
169 Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
170 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
171 Effects of acute ethanol treatment on NCCIT cells and NCCIT cell-derived embryoid bodies (EBs). Toxicol In Vitro. 2010 Sep;24(6):1696-704. doi: 10.1016/j.tiv.2010.05.017. Epub 2010 May 26.
172 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
173 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
174 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
175 Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-beta-dependent mechanisms. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4558-66.
176 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
177 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
178 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
179 Identification of biomarkers modulated by the rexinoid LGD1069 (bexarotene) in human breast cells using oligonucleotide arrays. Cancer Res. 2006 Dec 15;66(24):12009-18.
180 A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies. PLoS Med. 2006 Dec;3(12):e486. doi: 10.1371/journal.pmed.0030486.
181 Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
182 Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
183 Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
184 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
185 Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells. Lipids Health Dis. 2010 Jun 2;9:56. doi: 10.1186/1476-511X-9-56.
186 Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
187 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
188 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
189 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
190 Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
191 Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: role of nuclear factor-kappaB and reactive oxygen species. J Cell Biochem. 2005 Aug 1;95(5):955-69. doi: 10.1002/jcb.20452.
192 Atorvastatin affects several angiogenic mediators in human endothelial cells. Endothelium. 2005 Sep-Dec;12(5-6):233-41.
193 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
194 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
195 Biological specificity of CDK4/6 inhibitors: dose response relationship, in vivo signaling, and composite response signature. Oncotarget. 2017 Jul 4;8(27):43678-43691. doi: 10.18632/oncotarget.18435.
196 Gene expression profiling of early primary biliary cirrhosis: possible insights into the mechanism of action of ursodeoxycholic acid. Liver Int. 2008 Aug;28(7):997-1010. doi: 10.1111/j.1478-3231.2008.01744.x. Epub 2008 Apr 15.
197 Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake. Obesity (Silver Spring). 2010 Jan;18(1):27-34. doi: 10.1038/oby.2009.208. Epub 2009 Jun 25.
198 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
199 Mechanisms of dexamethasone-induced disturbed sleep and fatigue in paediatric patients receiving treatment for ALL. Eur J Cancer. 2010 Jul;46(10):1848-55. doi: 10.1016/j.ejca.2010.03.026. Epub 2010 Apr 17.
200 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
201 Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
202 ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
203 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
204 (9)-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7-Stimulated Human Coculture. J Pharmacol Exp Ther. 2019 Oct;371(1):191-201. doi: 10.1124/jpet.119.260661. Epub 2019 Aug 5.
205 Blood cell oxidative stress precedes hemolysis in whole blood-liver slice co-cultures of rat, dog, and human tissues. Toxicol Appl Pharmacol. 2010 May 1;244(3):354-65. doi: 10.1016/j.taap.2010.01.017. Epub 2010 Feb 6.
206 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
207 Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
208 The effects of quercetin on SW480 human colon carcinoma cells: a proteomic study. Nutr J. 2005 Mar 4;4:11.
209 Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
210 Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22.
211 Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
212 Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
213 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
214 Zinc induces chemokine and inflammatory cytokine release from human promonocytes. J Hazard Mater. 2011 Nov 30;196:335-41. doi: 10.1016/j.jhazmat.2011.09.035. Epub 2011 Sep 19.
215 Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
216 Evaluation of early biomarkers of muscle anabolic response to testosterone. J Cachexia Sarcopenia Muscle. 2011 Mar;2(1):45-56. doi: 10.1007/s13539-011-0021-y. Epub 2011 Feb 26.
217 Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation. Mol Endocrinol. 2002 Jun;16(6):1243-56.
218 Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
219 Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
220 Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells. J Pharmacol Exp Ther. 2003 Jun;305(3):932-42. doi: 10.1124/jpet.103.049098. Epub 2003 Mar 20.
221 Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
222 Hypomethylation mediated by decreased DNMTs involves in the activation of proto-oncogene MPL in TK6 cells treated with hydroquinone. Toxicol Lett. 2012 Mar 25;209(3):239-45. doi: 10.1016/j.toxlet.2011.12.020. Epub 2012 Jan 8.
223 Thalidomide alters c-MYB and PIM-1 signaling in K-562 cells. Pharmacol Res. 2006 Aug;54(2):91-6. doi: 10.1016/j.phrs.2006.02.010. Epub 2006 Mar 8.
224 Investigation of in vitro odonto/osteogenic capacity of cannabidiol on human dental pulp cell. J Dent. 2021 Jun;109:103673. doi: 10.1016/j.jdent.2021.103673. Epub 2021 Apr 16.
225 Statin-mediated reduction of osteopontin expression induces apoptosis and cell growth arrest in ovarian clear cell carcinoma. Oncol Rep. 2011 Jan;25(1):41-7.
226 Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
227 Troglitazone, a PPARgamma ligand, inhibits osteopontin gene expression in human monocytes/macrophage THP-1 cells. J Atheroscler Thromb. 2000;7(2):77-82. doi: 10.5551/jat1994.7.77.
228 Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
229 Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
230 Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. Int J Mol Sci. 2016 Dec 23;18(1):26. doi: 10.3390/ijms18010026.
231 Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
232 K-RAS transformation in prostate epithelial cell overcomes H2O2-induced apoptosis via upregulation of gamma-glutamyltransferase-2. Toxicol In Vitro. 2012 Apr;26(3):429-34. doi: 10.1016/j.tiv.2012.01.013. Epub 2012 Jan 17.
233 Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
234 High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities. Arch Toxicol. 2017 Mar;91(3):1367-1383. doi: 10.1007/s00204-016-1781-0. Epub 2016 Jun 29.
235 Enhanced GRP78 protein expression via the IRE1/ASK1/p38 MAPK pathway during As(2)O(3)-induced endoplasmic reticulum stress in BEAS-2B cells. Toxicology. 2021 Oct;462:152962. doi: 10.1016/j.tox.2021.152962. Epub 2021 Sep 21.
236 [Simvastatin-induced apoptosis of K562 cells is mediated by endoplasmic reticulum stress]. Yao Xue Xue Bao. 2008 Apr;43(4):371-7.
237 Chronic oxycodone induces integrated stress response in rat brain. BMC Neurosci. 2015 Sep 16;16:58. doi: 10.1186/s12868-015-0197-8.
238 Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin. Toxicol Mech Methods. 2017 Mar;27(3):165-172. doi: 10.1080/15376516.2016.1273424. Epub 2017 Jan 8.
239 Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors. Biochem J. 1993 Mar 15;290 ( Pt 3)(Pt 3):701-6. doi: 10.1042/bj2900701.
240 Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
241 A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
242 In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies. Toxicol Sci. 2007 Sep;99(1):162-73.
243 Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity. Biochim Biophys Acta. 2005 Oct 15;1731(1):48-56. doi: 10.1016/j.bbaexp.2005.08.006. Epub 2005 Sep 1.
244 Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nat Commun. 2018 Aug 9;9(1):3069. doi: 10.1038/s41467-018-05402-2.
245 Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain Res. 2008 Jan 29;1191:1-11.
246 Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling. Free Radic Biol Med. 2012 Jul 1;53(1):44-50. doi: 10.1016/j.freeradbiomed.2012.04.031. Epub 2012 May 9.
247 Nitric oxide causes anoikis through attenuation of E-cadherin and activation of caspase-3 in human gastric carcinoma AZ-521 cells infected with Mycoplasma hyorhinis. J Vet Med Sci. 2010 Jul;72(7):869-74.
248 Induced differentiation in HT29, a human colon adenocarcinoma cell line. J Cell Sci. 1999 Aug;112 ( Pt 16):2657-66. doi: 10.1242/jcs.112.16.2657.
249 Antitumoral activity of liraglutide, a new DNMT inhibitor in breast cancer cells in vitro and in vivo. Chem Biol Interact. 2021 Nov 1;349:109641. doi: 10.1016/j.cbi.2021.109641. Epub 2021 Sep 14.
250 Troglitazone increases expression of E-cadherin and claudin 4 in human pancreatic cancer cells. Biochem Biophys Res Commun. 2009 Mar 13;380(3):614-9. doi: 10.1016/j.bbrc.2009.01.134. Epub 2009 Jan 27.
251 Regulation of epithelial cell morphology and functions approaching to more in vivo-like by modifying polyethylene glycol on polysulfone membranes. PLoS One. 2012;7(4):e36110.
252 Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
253 Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
254 Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
255 Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
256 Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006 Jan 10;24(2):274-87. doi: 10.1200/JCO.2005.02.9405. Epub 2005 Dec 19.
257 Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
258 Ouabain induces apoptotic cell death in human prostate DU 145 cancer cells through DNA damage and TRAIL pathways. Environ Toxicol. 2019 Dec;34(12):1329-1339. doi: 10.1002/tox.22834. Epub 2019 Aug 21.
259 Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage. Carcinogenesis. 2014 Mar;35(3):692-702. doi: 10.1093/carcin/bgt366. Epub 2013 Nov 5.
260 Induction of the DNA repair gene O6-methylguanine-DNA methyltransferase by dexamethasone in glioblastomas. J Neurosurg. 2004 Oct;101(4):659-63. doi: 10.3171/jns.2004.101.4.0659.
261 Phenytoin may increase the efficacy of temozolomide by methylating DNA-repair enzyme, O6-methylguanine-DNA methyltransferase in patients with glioblastoma. Med Hypotheses. 2005;65(4):819-20. doi: 10.1016/j.mehy.2005.04.007.
262 Pharmacokinetic, biochemical and clinical effects of dimethyltriazenoimidazole-4-carboxamide-bischloroethylnitrosourea combination therapy in patients with advanced breast cancer. Int J Cancer. 2003 Feb 20;103(5):686-92. doi: 10.1002/ijc.10849.
263 Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N'-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells. Mol Pharmacol. 2008 Aug;74(2):517-26. doi: 10.1124/mol.107.043620. Epub 2008 May 20.
264 Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. 2005 Jul 7;5:74. doi: 10.1186/1471-2407-5-74.
265 Ursodeoxycholic acid suppresses Cox-2 expression in colon cancer: roles of Ras, p38, and CCAAT/enhancer-binding protein. Nutr Cancer. 2008;60(3):389-400.
266 Quercetin represses apolipoprotein B expression by inhibiting the transcriptional activity of C/EBP. PLoS One. 2015 Apr 15;10(4):e0121784. doi: 10.1371/journal.pone.0121784. eCollection 2015.
267 Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
268 Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Int J Mol Sci. 2023 Mar 15;24(6):5604. doi: 10.3390/ijms24065604.
269 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
270 D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
271 The retinoid anticancer signal: mechanisms of target gene regulation. Br J Cancer. 2005 Aug 8;93(3):310-8. doi: 10.1038/sj.bjc.6602700.
272 Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
273 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
274 Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
275 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
276 Identification of novel activators of the metal responsive transcription factor (MTF-1) using a gene expression biomarker in a microarray compendium. Metallomics. 2020 Sep 23;12(9):1400-1415. doi: 10.1039/d0mt00071j.
277 Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
278 Progesterone and calcitriol attenuate inflammatory cytokines CXCL1 and CXCL2 in ovarian and endometrial cancer cells. J Cell Biochem. 2012 Oct;113(10):3143-52. doi: 10.1002/jcb.24191.
279 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
280 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
281 Considering temozolomide as a novel potential treatment for esophageal cancer. Cancer. 2011 May 1;117(9):2004-16. doi: 10.1002/cncr.25687. Epub 2010 Nov 8.
282 Ursodeoxycholic acid reduces increased circulating endothelin 2 in primary biliary cirrhosis. Aliment Pharmacol Ther. 2005 Feb 1;21(3):227-34. doi: 10.1111/j.1365-2036.2005.02307.x.
283 The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
284 Application of cDNA microarray to the study of arsenic-induced liver diseases in the population of Guizhou, China. Toxicol Sci. 2001 Jan;59(1):185-92.
285 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
286 Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity. Toxicol Sci. 2011 Dec;124(2):278-90. doi: 10.1093/toxsci/kfr225. Epub 2011 Aug 27.
287 Mapping the dynamics of Nrf2 antioxidant and NFB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses. Toxicol In Vitro. 2022 Oct;84:105419. doi: 10.1016/j.tiv.2022.105419. Epub 2022 Jun 17.
288 Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
289 The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro. Toxicol Appl Pharmacol. 2020 Mar 15;391:114915. doi: 10.1016/j.taap.2020.114915. Epub 2020 Feb 6.
290 Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer. J Biol Chem. 2003 Nov 28;278(48):47762-75.
291 Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells. Biochem J. 2006 Feb 15;394(Pt 1):317-24.
292 Acetaminophen selectively suppresses peripheral prostaglandin E2 release and increases COX-2 gene expression in a clinical model of acute inflammation. Pain. 2007 Jun;129(3):279-86.
293 Mitochondrial involvement in schizophrenia and other functional psychoses. Neurochem Res. 1996 Sep;21(9):995-1004.
294 Quercetin reduces oxidative damage induced by paraquat via modulating expression of antioxidant genes in A549 cells. J Appl Toxicol. 2013 Dec;33(12):1460-7. doi: 10.1002/jat.2812. Epub 2012 Sep 20.
295 The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model. Anesth Analg. 2008 Jan;106(1):321-7, table of contents.
296 The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling. Oncogene. 2001 Feb 1;20(5):645-53. doi: 10.1038/sj.onc.1204123.
297 Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines. Breast. 2018 Oct;41:34-41. doi: 10.1016/j.breast.2018.06.009. Epub 2018 Jun 22.
298 Cross-talk between non-genomic and genomic signalling pathways--distinct effect profiles of environmental estrogens. Toxicol Appl Pharmacol. 2010 Jun 1;245(2):160-70. doi: 10.1016/j.taap.2010.02.015. Epub 2010 Mar 4.
299 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
300 Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. Eur Rev Med Pharmacol Sci. 2016;20(6):1203-13.
301 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
302 Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells. J Pharmacol Exp Ther. 2001 Sep;298(3):976-85.
303 Differential effects of statins on relevant functions of human monocyte-derived dendritic cells. J Leukoc Biol. 2006 Mar;79(3):529-38. doi: 10.1189/jlb.0205064. Epub 2005 Dec 30.
304 Curcumin reduces the expression of survivin, leading to enhancement of arsenic trioxide-induced apoptosis in myelodysplastic syndrome and leukemia stem-like cells. Oncol Rep. 2016 Sep;36(3):1233-42. doi: 10.3892/or.2016.4944. Epub 2016 Jul 15.
305 1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J Immunol. 2000 Mar 1;164(5):2405-11. doi: 10.4049/jimmunol.164.5.2405.
306 Fenofibrate induces effective apoptosis in mantle cell lymphoma by inhibiting the TNFalpha/NF-kappaB signaling axis. Leukemia. 2010 Aug;24(8):1476-86. doi: 10.1038/leu.2010.117. Epub 2010 Jun 3.
307 Bisphenol A effects on gene expression in adipocytes from children: association with metabolic disorders. J Mol Endocrinol. 2015 Jun;54(3):289-303.
308 Levonorgestrel enhances spermatogenesis suppression by testosterone with greater alteration in testicular gene expression in men. Biol Reprod. 2009 Mar;80(3):484-92.
309 Global expression profiling of theophylline response genes in macrophages: evidence of airway anti-inflammatory regulation. Respir Res. 2005 Aug 8;6(1):89. doi: 10.1186/1465-9921-6-89.
310 Bisphenol A and bisphenol S induce distinct transcriptional profiles in differentiating human primary preadipocytes. PLoS One. 2016 Sep 29;11(9):e0163318.
311 Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. Pharmacogenet Genomics. 2006 Apr;16(4):287-96. doi: 10.1097/01.fpc.0000189800.88596.7a.
312 Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
313 Isoproterenol effects evaluated in heart slices of human and rat in comparison to rat heart in vivo. Toxicol Appl Pharmacol. 2014 Jan 15;274(2):302-12.
314 Mitochondrial dysfunction induced by leflunomide and its active metabolite. Toxicology. 2018 Mar 1;396-397:33-45.
315 A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
316 Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
317 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
318 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
319 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
320 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
321 Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
322 Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
323 Atorvastatin and pravastatin stimulate nitric oxide and reactive oxygen species generation, affect mitochondrial network architecture and elevate nicotinamide N-methyltransferase level in endothelial cells. J Appl Toxicol. 2021 Jul;41(7):1076-1088. doi: 10.1002/jat.4094. Epub 2020 Oct 19.
324 In vitro assessment of drug-induced liver steatosis based on human dermal stem cell-derived hepatic cells. Arch Toxicol. 2016 Mar;90(3):677-89. doi: 10.1007/s00204-015-1483-z. Epub 2015 Feb 26.
325 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
326 Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
327 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
328 Gene expression profiling of human peri-implantation endometria between natural and stimulated cycles. Fertil Steril. 2008 Dec;90(6):2152-64.
329 Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
330 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
331 Gene expression profile changes in NB4 cells induced by arsenic trioxide. Acta Pharmacol Sin. 2003 Jul;24(7):646-50.
332 Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
333 Clomiphene citrate versus letrozole: molecular analysis of the endometrium in women with polycystic ovary syndrome. Fertil Steril. 2011 Oct;96(4):1051-6. doi: 10.1016/j.fertnstert.2011.07.1092.
334 In vitro readthrough of termination codons by gentamycin in the Stve-Wiedemann Syndrome. Eur J Hum Genet. 2010 Jan;18(1):130-2. doi: 10.1038/ejhg.2009.122.
335 Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer. Mol Oncol. 2011 Oct;5(5):438-53. doi: 10.1016/j.molonc.2011.07.003. Epub 2011 Jul 26.
336 Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49. doi: 10.1016/j.placenta.2019.10.008. Epub 2019 Oct 17.
337 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
338 Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
339 Tyrosine phosphorylation of the scaffold protein IQGAP1 in the MET pathway alters function. J Biol Chem. 2020 Dec 25;295(52):18105-18121. doi: 10.1074/jbc.RA120.015891. Epub 2020 Oct 21.
340 Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
341 Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR. Yakugaku Zasshi. 2002 May;122(5):339-61.
342 Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
343 Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. BMC Cancer. 2007 Dec 11;7:223.
344 Iminoenamine based novel androgen receptor antagonist exhibited anti-prostate cancer activity in androgen independent prostate cancer cells through inhibition of AKT pathway. Chem Biol Interact. 2017 Sep 25;275:22-34. doi: 10.1016/j.cbi.2017.07.023. Epub 2017 Jul 27.
345 Arsenic trioxide induces differentiation of cancer stem cells in hepatocellular carcinoma through inhibition of LIF/JAK1/STAT3 and NF-kB signaling pathways synergistically. Clin Transl Med. 2021 Feb;11(2):e335. doi: 10.1002/ctm2.335.
346 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
347 Microarray-based detection and expression analysis of extracellular matrix proteins in drug?resistant ovarian cancer cell lines. Oncol Rep. 2014 Nov;32(5):1981-90. doi: 10.3892/or.2014.3468. Epub 2014 Sep 9.
348 Transcription Factor IIA tau is associated with undifferentiated cells and its gene expression is repressed in primary neurons at the chromatin level in vivo. Stem Cells Dev. 2006 Apr;15(2):175-90. doi: 10.1089/scd.2006.15.175.
349 Arsenic-induced sumoylation of Mus81 is involved in regulating genomic stability. Cell Cycle. 2017 Apr 18;16(8):802-811. doi: 10.1080/15384101.2017.1302628. Epub 2017 Mar 20.
350 Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
351 Effect of prenatal arsenic exposure on DNA methylation and leukocyte subpopulations in cord blood. Epigenetics. 2014 May;9(5):774-82. doi: 10.4161/epi.28153. Epub 2014 Feb 13.
352 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
353 Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
354 Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
355 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
356 Astaxanthin protects mesenchymal stem cells from oxidative stress by direct scavenging of free radicals and modulation of cell signaling. Chem Biol Interact. 2021 Jan 5;333:109324. doi: 10.1016/j.cbi.2020.109324. Epub 2020 Nov 17.
357 Comparative effects of retinoic acid, vitamin D and resveratrol alone and in combination with adenosine analogues on methylation and expression of phosphatase and tensin homologue tumour suppressor gene in breast cancer cells. Br J Nutr. 2012 Mar;107(6):781-90. doi: 10.1017/S0007114511003631. Epub 2011 Aug 1.
358 Arsenic trioxide inhibits the proliferation of myeloma cell line through notch signaling pathway. Cancer Cell Int. 2013 Mar 13;13(1):25. doi: 10.1186/1475-2867-13-25.
359 Mechanism of thalidomide to enhance cytotoxicity of temozolomide in U251-MG glioma cells in vitro. Chin Med J (Engl). 2009 Jun 5;122(11):1260-6.
360 Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. Mol Cancer. 2006 May 18;5:20. doi: 10.1186/1476-4598-5-20.
361 RAB8 enhances TMEM205-mediated cisplatin resistance. Pharm Res. 2012 Mar;29(3):643-50. doi: 10.1007/s11095-011-0562-y. Epub 2011 Oct 4.
362 Regulation of antiprotease and antimicrobial protein secretion by airway submucosal gland serous cells. J Biol Chem. 2004 Sep 10;279(37):38854-60. doi: 10.1074/jbc.M407077200. Epub 2004 Jul 2.
363 DNA microarray analysis of changes in gene expression induced by 1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60 cells. Biomed Res. 2006 Jun;27(3):99-109. doi: 10.2220/biomedres.27.99.
364 Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
365 TGF-1 signaling protects retinal ganglion cells from oxidative stress via modulation of the HO-1/Nrf2 pathway. Chem Biol Interact. 2020 Nov 1;331:109249. doi: 10.1016/j.cbi.2020.109249. Epub 2020 Sep 24.
366 Troglitazone suppresses transforming growth factor beta-mediated fibrogenesis in retinal pigment epithelial cells. Mol Vis. 2008 Jan 18;14:95-104.
367 Towards dissecting the pathogenesis of retinoid-induced hair loss: all-trans retinoic acid induces premature hair follicle regression (catagen) by upregulation of transforming growth factor-beta2 in the dermal papilla. J Invest Dermatol. 2005 Jun;124(6):1119-26. doi: 10.1111/j.0022-202X.2005.23686.x.
368 Role of microRNA-4516 involved autophagy associated with exposure to fine particulate matter. Oncotarget. 2016 Jul 19;7(29):45385-45397. doi: 10.18632/oncotarget.9978.
369 Transcriptional profiling of MCF7 breast cancer cells in response to 5-Fluorouracil: relationship with cell cycle changes and apoptosis, and identification of novel targets of p53. Int J Cancer. 2006 Sep 1;119(5):1164-75.
370 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
371 Expression and DNA methylation changes in human breast epithelial cells after bisphenol A exposure. Int J Oncol. 2012 Jul;41(1):369-77.
372 A systematic assessment of radiation dose enhancement by 5-Aza-2'-deoxycytidine and histone deacetylase inhibitors in head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2009 Mar 1;73(3):904-12. doi: 10.1016/j.ijrobp.2008.10.032.
373 Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: triggering the differentiation syndrome. Blood. 2009 Dec 24;114(27):5512-21. doi: 10.1182/blood-2009-02-204834. Epub 2009 Oct 14.
374 Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells. Clin Exp Immunol. 2012 Apr;168(1):113-24. doi: 10.1111/j.1365-2249.2011.04549.x.
375 Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
376 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
377 A genome-wide analysis of targets of macrolide antibiotics in mammalian cells. J Biol Chem. 2020 Feb 14;295(7):2057-2067. doi: 10.1074/jbc.RA119.010770. Epub 2020 Jan 8.
378 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
379 A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
380 MiR-146a affects the alteration in myeloid differentiation induced by hydroquinone in human CD34(+) hematopoietic progenitor cells and HL-60 cells. Toxicol Res (Camb). 2016 Feb 16;5(3):848-858. doi: 10.1039/c5tx00419e. eCollection 2016 May 1.
381 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
382 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
383 Linalool is a PPARalpha ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome. J Lipid Res. 2014 Jun;55(6):1098-110.
384 ATPR induces acute promyelocytic leukemia cells differentiation and growth arrest by blockade of SHP2/Rho/ROCK1 pathway. Toxicol Appl Pharmacol. 2020 Jul 15;399:115053. doi: 10.1016/j.taap.2020.115053. Epub 2020 May 15.
385 Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. Med Oncol. 2010 Sep;27(3):833-42. doi: 10.1007/s12032-009-9294-9. Epub 2009 Sep 10.
386 Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
387 Decline in arylsulfatase B expression increases EGFR expression by inhibiting the protein-tyrosine phosphatase SHP2 and activating JNK in prostate cells. J Biol Chem. 2018 Jul 13;293(28):11076-11087. doi: 10.1074/jbc.RA117.001244. Epub 2018 May 24.
388 DNA microarray analysis of vitamin D-induced gene expression in a human colon carcinoma cell line. Physiol Genomics. 2004 Apr 13;17(2):122-9. doi: 10.1152/physiolgenomics.00002.2003.
389 Retinoic acid via RARalpha inhibits the expression of 24-hydroxylase in human prostate stromal cells. Biochem Biophys Res Commun. 2005 Dec 30;338(4):1973-81. doi: 10.1016/j.bbrc.2005.10.178. Epub 2005 Nov 7.
390 Actions of Vitamin D3, analogs on human prostate cancer cell lines: comparison with 1,25-dihydroxyvitamin D3. Endocrinology. 1995 Jan;136(1):20-6.
391 Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
392 Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
393 Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia. J Clin Invest. 2005 Jan;115(1):177-86.
394 19-Nor-1,25(OH)2D2 (a novel, noncalcemic vitamin D analogue), combined with arsenic trioxide, has potent antitumor activity against myeloid leukemia. Cancer Res. 2005 Mar 15;65(6):2488-97.
395 Similarities and differences between two modes of antagonism of the thyroid hormone receptor. ACS Chem Biol. 2011 Oct 21;6(10):1096-106.
396 The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. Hum Reprod. 2010 Nov;25(11):2859-69.
397 Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
398 Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway. Sci Rep. 2019 Jan 24;9(1):675.
399 Etoposide induces necrosis through p53-mediated antiapoptosis in human kidney proximal tubule cells. Toxicol Sci. 2015 Nov;148(1):204-19.
400 Association of H3K79 monomethylation (an epigenetic signature) with arsenic-induced skin lesions. Mutat Res. 2018 Jan;807:1-9. doi: 10.1016/j.mrfmmm.2017.11.001. Epub 2017 Nov 14.
401 Effects of Benzophenone-3 and Propylparaben on Estrogen Receptor-Dependent R-Loops and DNA Damage in Breast Epithelial Cells and Mice. Environ Health Perspect. 2020 Jan;128(1):17002. doi: 10.1289/EHP5221. Epub 2020 Jan 15.
402 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
403 Marked regression of liver metastasis by combined therapy of ultrasound-mediated NF kappaB-decoy transfer and transportal injection of paclitaxel, in mouse. Int J Cancer. 2008 Apr 1;122(7):1645-56. doi: 10.1002/ijc.23280.
404 2,3,7,8-tetrachlorodibenzo-p-dioxin augments the modulation of gene expression mediated by the thyroid hormone receptor. Toxicol Appl Pharmacol. 2004 Feb 1;194(3):201-10. doi: 10.1016/j.taap.2003.09.010.
405 Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells. Carcinogenesis. 2006 May;27(5):916-24. doi: 10.1093/carcin/bgi312. Epub 2005 Dec 16.
406 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
407 Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis. Mol Cancer Ther. 2004 Jan;3(1):71-84.
408 Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
409 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
410 Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. Int J Cancer. 2008 Aug 15;123(4):951-7. doi: 10.1002/ijc.23593.
411 Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
412 The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells. Chem Biol Interact. 2019 Apr 1;302:28-35. doi: 10.1016/j.cbi.2019.01.033. Epub 2019 Jan 28.
413 Inhibition of PI3K pathway using BKM120 intensified the chemo-sensitivity of breast cancer cells to arsenic trioxide (ATO). Int J Biochem Cell Biol. 2019 Nov;116:105615. doi: 10.1016/j.biocel.2019.105615. Epub 2019 Sep 17.
414 Etodolac inhibits EBER expression and induces Bcl-2-regulated apoptosis in Burkitt's lymphoma cells. Eur J Haematol. 2005 Sep;75(3):212-20. doi: 10.1111/j.1600-0609.2005.00498.x.
415 Apoptosis induction by 1alpha,25-dihydroxyvitamin D3 in prostate cancer. Mol Cancer Ther. 2002 Jul;1(9):667-77.
416 Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
417 Hydroxychloroquine-inhibited dengue virus is associated with host defense machinery. J Interferon Cytokine Res. 2015 Mar;35(3):143-56. doi: 10.1089/jir.2014.0038. Epub 2014 Oct 16.
418 Controlled diesel exhaust and allergen coexposure modulates microRNA and gene expression in humans: Effects on inflammatory lung markers. J Allergy Clin Immunol. 2016 Dec;138(6):1690-1700. doi: 10.1016/j.jaci.2016.02.038. Epub 2016 Apr 24.
419 Molecular characterization of a toxicological tipping point during human stem cell differentiation. Reprod Toxicol. 2020 Jan;91:1-13. doi: 10.1016/j.reprotox.2019.10.001. Epub 2019 Oct 7.
420 5-Fluorouracil: identification of novel downstream mediators of tumour response. Anticancer Res. 2004 Mar-Apr;24(2A):417-23.
421 Cardiac toxicity from ethanol exposure in human-induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci. 2019 May 1;169(1):280-292.
422 High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells. Br J Nutr. 2008 Apr;99(4):703-8.
423 Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
424 Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
425 Differentially expressed genes in the prostate cancer cell line LNCaP after exposure to androgen and anti-androgen. Cancer Genet Cytogenet. 2006 Apr 15;166(2):130-8. doi: 10.1016/j.cancergencyto.2005.09.012.
426 Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
427 Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod. 2011 Jul;26(7):1813-25.
428 Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
429 The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
430 Comparison of effects of bezafibrate and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 and adipocytokine levels in dyslipidemic subjects with impaired glucose tolerance or type 2 diabetes mellitus: results from a crossover study. Atherosclerosis. 2011 Jul;217(1):165-70. doi: 10.1016/j.atherosclerosis.2011.02.012. Epub 2011 Feb 22.
431 Peroxisome Proliferator-activated receptor activation by ligands and dephosphorylation induces proprotein convertase subtilisin kexin type 9 and low density lipoprotein receptor expression. J Biol Chem. 2012 Jul 6;287(28):23667-77. doi: 10.1074/jbc.M112.350181. Epub 2012 May 16.
432 Activation of inflammation/NF-kappaB signaling in infants born to arsenic-exposed mothers. PLoS Genet. 2007 Nov;3(11):e207.
433 Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
434 Transcriptome dynamics of alternative splicing events revealed early phase of apoptosis induced by methylparaben in H1299 human lung carcinoma cells. Arch Toxicol. 2020 Jan;94(1):127-140. doi: 10.1007/s00204-019-02629-w. Epub 2019 Nov 20.
435 Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134. doi: 10.1016/j.envres.2019.03.035. Epub 2019 Mar 18.
436 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
437 Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia. J Exp Med. 2010 Apr 12;207(4):731-50. doi: 10.1084/jem.20091488. Epub 2010 Apr 5.
438 ZD6474 inhibits tumor growth and intraperitoneal dissemination in a highly metastatic orthotopic gastric cancer model. Int J Cancer. 2006 Jan 15;118(2):483-9. doi: 10.1002/ijc.21340.
439 Inhibition of fatty acid synthase expression by 1alpha,25-dihydroxyvitamin D3 in prostate cancer cells. J Steroid Biochem Mol Biol. 2003 May;85(1):1-8. doi: 10.1016/s0960-0760(03)00142-0.
440 Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
441 Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
442 Inhibitory effects of N-(4-hydrophenyl) retinamide on liver cancer and malignant melanoma cells. World J Gastroenterol. 2005 Oct 7;11(37):5763-9. doi: 10.3748/wjg.v11.i37.5763.
443 Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
444 Inhibition of CXCL12-mediated chemotaxis of Jurkat cells by direct immunotoxicants. Arch Toxicol. 2016 Jul;90(7):1685-94. doi: 10.1007/s00204-015-1585-7. Epub 2015 Aug 28.
445 A comparative transcriptomic study on the effects of valproic acid on two different hESCs lines in a neural teratogenicity test system. Toxicol Lett. 2014 Nov 18;231(1):38-44.
446 Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
447 Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
448 Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
449 Capsaicin inhibits the migration, invasion and EMT of renal cancer cells by inducing AMPK/mTOR-mediated autophagy. Chem Biol Interact. 2022 Oct 1;366:110043. doi: 10.1016/j.cbi.2022.110043. Epub 2022 Aug 28.
450 Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
451 Identification of troglitazone responsive genes: induction of RTP801 during troglitazone-induced apoptosis in Hep 3B cells. BMB Rep. 2010 Sep;43(9):599-603. doi: 10.5483/BMBRep.2010.43.9.599.
452 In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
453 Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
454 Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst Biol. 2012 Dec 10;6:152.
455 Transcriptomic analysis of human primary bronchial epithelial cells after chloropicrin treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.
456 Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615. doi: 10.1007/s00204-020-02970-5. Epub 2021 Jan 29.
457 The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
458 Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis. PLoS One. 2018 Nov 27;13(11):e0207915. doi: 10.1371/journal.pone.0207915. eCollection 2018.
459 Evaluation of developmental toxicity using undifferentiated human embryonic stem cells. J Appl Toxicol. 2015 Feb;35(2):205-18.
460 An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide. Exp Hematol. 2007 Feb;35(2):252-62.
461 Selenium is critical for cancer-signaling gene expression but not cell proliferation in human colon Caco-2 cells. Biofactors. 2007;31(3-4):155-64. doi: 10.1002/biof.5520310302.
462 Plasma proteinase inhibitor activity and hemostasis tests in children with nephrotic syndrome. Effect of prednisone alone and prednisone plus epsilon-aminocaproic acid treatment regimens: a preliminary report. Am J Ther. 2001 Mar-Apr;8(2):97-107. doi: 10.1097/00045391-200103000-00004.
463 Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells. Biol Pharm Bull. 2007 Feb;30(2):247-53. doi: 10.1248/bpb.30.247.
464 Estradiol attenuates EGF-induced rapid uPAR mobilization and cell migration via the G-protein-coupled receptor 30 in ovarian cancer cells. Int J Gynecol Cancer. 2009 Feb;19(2):214-22. doi: 10.1111/IGC.0b013e31819bcb75.
465 N-O Reduction and ROS-Mediated AKT/FOXO1 and AKT/P53 Pathways Are Involved in Growth Promotion and Cytotoxicity of Cyadox. Chem Res Toxicol. 2018 Nov 19;31(11):1219-1229. doi: 10.1021/acs.chemrestox.8b00194. Epub 2018 Oct 11.
466 Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. Neurotoxicology. 2015 Sep;50:56-70.
467 Nevirapine restores androgen signaling in hormone-refractory human prostate carcinoma cells both in vitro and in vivo. Prostate. 2009 May 15;69(7):744-54. doi: 10.1002/pros.20923.
468 Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir6.2 and their relationships to glucose- and tolbutamide-induced insulin secretion, the insulin sensitivity index, and NIDDM. Diabetes. 1997 Mar;46(3):508-12. doi: 10.2337/diab.46.3.508.
469 A receptor mechanism for the inhibition of insulin release by epinephrine in man. J Clin Invest. 1967 Jan;46(1):86-94. doi: 10.1172/JCI105514.
470 Vasodilatory effects of troglitazone improve blood pressure at rest and during mental stress in type 2 diabetes mellitus. Hypertension. 1999 Jul;34(1):83-8. doi: 10.1161/01.hyp.34.1.83.
471 Quinapril treatment restores the vasodilator action of insulin in fructose-hypertensive rats. Clin Exp Pharmacol Physiol. 2002 May-Jun;29(5-6):381-5. doi: 10.1046/j.1440-1681.2002.03668.x.
472 Retinoic acid can induce markers of endocrine transdifferentiation in pancreatic ductal adenocarcinoma: preliminary observations from an in vitro cell line model. J Clin Pathol. 2006 Jun;59(6):603-10. doi: 10.1136/jcp.2005.032003. Epub 2006 Feb 10.
473 Effects of prolonged in vitro exposure to sulphonylureas on the function and survival of human islets. J Diabetes Complications. 2005 Jan-Feb;19(1):60-4. doi: 10.1016/j.jdiacomp.2004.05.001.
474 Clonidine effect on insulin secretion and lipolysis in man. Acta Diabetol Lat. 1978 May-Aug;15(3-4):192-7. doi: 10.1007/BF02581064.
475 Beta-adrenergic contribution to glucagon-induced glucose production and insulin secretion in uremia. Am J Physiol. 1986 Sep;251(3 Pt 1):E322-7. doi: 10.1152/ajpendo.1986.251.3.E322.
476 Effect of testosterone replacement on whole body glucose utilisation and other cardiovascular risk factors in males with idiopathic hypogonadotrophic hypogonadism. Horm Metab Res. 1998 Oct;30(10):642-5. doi: 10.1055/s-2007-978950.
477 Pattern of expression of apoptosis and inflammatory genes in humans exposed to arsenic and/or fluoride. Sci Total Environ. 2010 Jan 15;408(4):760-7. doi: 10.1016/j.scitotenv.2009.11.016. Epub 2009 Dec 4.
478 Human 3D multicellular microtissues: an upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity. Toxicol Lett. 2019 Sep 15;312:34-44.
479 Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells. Br J Pharmacol. 2013 May;169(1):167-78.
480 Nonsteroidal antiinflammatory drugs and decreased risk of advanced prostate cancer: modification by lymphotoxin alpha. Am J Epidemiol. 2006 Nov 15;164(10):984-9. doi: 10.1093/aje/kwj294. Epub 2006 Aug 24.
481 Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells: a triple-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery disease. Cardiovasc Drugs Ther. 2013 Feb;27(1):37-48. doi: 10.1007/s10557-012-6427-8.
482 Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells. J Biochem Mol Toxicol. 2020 Feb;34(2):e22433. doi: 10.1002/jbt.22433. Epub 2020 Jan 9.
483 A cell impedance-based real-time in vitro assay to assess the toxicity of amphotericin B formulations. Toxicol Appl Pharmacol. 2017 Nov 1;334:18-23. doi: 10.1016/j.taap.2017.08.017. Epub 2017 Sep 1.
484 CBD Promotes Oral Ulcer Healing via Inhibiting CMPK2-Mediated Inflammasome. J Dent Res. 2022 Feb;101(2):206-215. doi: 10.1177/00220345211024528. Epub 2021 Jul 16.
485 Anti-inflammatory effects of the GABA(B) receptor agonist baclofen in allergic contact dermatitis. Exp Dermatol. 2010 Jul 1;19(7):661-6. doi: 10.1111/j.1600-0625.2010.01076.x. Epub 2010 Feb 25.
486 Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways. World J Gastrointest Oncol. 2022 Feb 15;14(2):450-477. doi: 10.4251/wjgo.v14.i2.450.
487 Sulfasalazine unveils a contact-independent HSV-TK/ganciclovir gene therapy bystander effect in malignant gliomas. Int J Oncol. 2007 Jan;30(1):283-90.
488 Regulatory role of nitric oxide on monocyte-derived dendritic cell functions. J Interferon Cytokine Res. 2003 Aug;23(8):423-31. doi: 10.1089/107999003322277838.
489 Direct evidence for immunomodulatory properties of ribavirin on T-cell reactivity to hepatitis C virus. Antiviral Res. 2007 Jul;75(1):36-42. doi: 10.1016/j.antiviral.2006.11.008. Epub 2006 Dec 13.
490 Differential effects of three antibiotics on T helper cell cytokine expression. J Antimicrob Chemother. 2005 Sep;56(3):502-6. doi: 10.1093/jac/dki251. Epub 2005 Jul 8.
491 Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. J Immunol. 2008 May 15;180(10):6988-96. doi: 10.4049/jimmunol.180.10.6988.
492 The flavonoid, quercetin, differentially regulates Th-1 (IFNgamma) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells. Biochim Biophys Acta. 2002 Dec 16;1593(1):29-36. doi: 10.1016/s0167-4889(02)00328-2.
493 [Effects of vitamin A on the differentiation, maturation and functions of dendritic cells from cord blood]. Zhonghua Er Ke Za Zhi. 2004 May;42(5):340-3.
494 Effect of zidovudine therapy in patients with HIV infection on endogenous interferon plasma levels and the hepatic cytochrome P450 enzyme system. Chemotherapy. 1998 May-Jun;44(3):174-80. doi: 10.1159/000007112.
495 Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury. Chem Res Toxicol. 2016 Nov 21;29(11):1793-1795. doi: 10.1021/acs.chemrestox.6b00393. Epub 2016 Nov 9.
496 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
497 Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
498 Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
499 Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
500 Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. Arch Toxicol. 2018 Jun;92(6):2043-2054. doi: 10.1007/s00204-018-2199-7. Epub 2018 Mar 29.
501 Spironolactone induces apoptosis in human mononuclear cells. Association between apoptosis and cytokine suppression. Apoptosis. 2006 Apr;11(4):573-9. doi: 10.1007/s10495-006-4919-3.
502 C-reactive protein in heart failure: prognostic value and the effect of valsartan. Circulation. 2005 Sep 6;112(10):1428-34. doi: 10.1161/CIRCULATIONAHA.104.508465. Epub 2005 Aug 29.
503 Elevated C-reactive protein levels are associated with endothelial dysfunction in chronic cocaine users. Int J Cardiol. 2003 Apr;88(2-3):191-8. doi: 10.1016/s0167-5273(02)00394-7.
504 Acute effect of standard heparin versus low molecular weight heparin on oxidative stress and inflammation in hemodialysis patients. Ren Fail. 2006;28(8):723-7. doi: 10.1080/08860220600925594.
505 Effects of olanzapine on serum protein phosphorylation patterns in patients with schizophrenia. Proteomics Clin Appl. 2015 Oct;9(9-10):907-16. doi: 10.1002/prca.201400148. Epub 2015 May 15.
506 Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes. Life Sci. 2016 Jul 1;156:47-56.
507 Antineoplastic effects of gamma linolenic Acid on hepatocellular carcinoma cell lines. J Clin Biochem Nutr. 2010 Jul;47(1):81-90.
508 Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
509 Effect of simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, on alpha-fetoprotein gene expression through interaction with the ras-mediated pathway. J Hepatol. 1999 May;30(5):904-10. doi: 10.1016/s0168-8278(99)80146-9.
510 Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
511 Expression of AFP and STAT3 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in AFP-producing gastric cancer cells. PLoS One. 2013;8(1):e54774. doi: 10.1371/journal.pone.0054774. Epub 2013 Jan 30.
512 Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan;92(1):469-485.
513 Cytokine mRNA profiles in cultured human skin component cells exposed to various chemicals: a simulation model of epicutaneous stimuli induced by skin barrier perturbation in comparison with that due to exposure to haptens or irritant. J Dermatol Sci. 2001 Jun;26(2):85-93. doi: 10.1016/s0923-1811(00)00165-1.
514 Effects of luteolin, quercetin and baicalein on immunoglobulin E-mediated mediator release from human cultured mast cells. Clin Exp Allergy. 2000 Apr;30(4):501-8. doi: 10.1046/j.1365-2222.2000.00768.x.
515 Altered cytokine profiles of human retinal pigment epithelium: oxidant injury and replicative senescence. Mol Vis. 2013;19:718-28. Epub 2013 Mar 21.
516 Combination of thalidomide and cisplatin in an head and neck squamous cell carcinomas model results in an enhanced antiangiogenic activity in vitro and in vivo. Int J Cancer. 2007 Oct 15;121(8):1697-704. doi: 10.1002/ijc.22867.
517 Human corneal epithelial cell functional responses to inflammatory agents and their antagonists. Invest Ophthalmol Vis Sci. 1998 Dec;39(13):2562-71.
518 Increased inflammasome related gene expression profile in PBMC may facilitate T helper 17 cell induction in multiple sclerosis. Mol Immunol. 2015 Feb;63(2):521-9. doi: 10.1016/j.molimm.2014.10.008.
519 Acetylcholine and nicotine stimulate the release of granulocyte-macrophage colony stimulating factor from cultured human bronchial epithelial cells. Naunyn Schmiedebergs Arch Pharmacol. 1998 Apr;357(4):472-5. doi: 10.1007/pl00005195.
520 Kaempferol and quercetin stimulate granulocyte-macrophage colony-stimulating factor secretion in human prostate cancer cells. Mol Cell Endocrinol. 2008 Jun 11;287(1-2):57-64. doi: 10.1016/j.mce.2008.01.015. Epub 2008 Feb 3.
521 Effects of theophylline, dexamethasone and salbutamol on cytokine gene expression in human peripheral blood CD4+ T-cells. Eur Respir J. 1999 Nov;14(5):1106-12. doi: 10.1183/09031936.99.14511069.
522 Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
523 Anti-mycotics suppress interleukin-4 and interleukin-5 production in anti-CD3 plus anti-CD28-stimulated T cells from patients with atopic dermatitis. J Invest Dermatol. 2001 Dec;117(6):1635-46. doi: 10.1046/j.0022-202x.2001.01566.x.
524 Ribavirin polarizes human T cell responses towards a Type 1 cytokine profile. J Hepatol. 1999 Mar;30(3):376-82. doi: 10.1016/s0168-8278(99)80093-2.
525 Selective inhibition of interleukin-4 gene expression in human T cells by aspirin. Blood. 2001 Mar 15;97(6):1742-9. doi: 10.1182/blood.v97.6.1742.
526 Immune responses in autoimmune hepatitis: effect of prednisone and azathioprine treatment: case report. Int J Med Sci. 2009 Jun 30;6(4):177-83. doi: 10.7150/ijms.6.177.
527 Paradoxical immunologic effects of 2-CdA therapy: comment on the article by Davis et al. Arthritis Rheum. 1998 Sep;41(9):1704-5. doi: 10.1002/1529-0131(199809)41:9<1704::AID-ART26>3.0.CO;2-9.
528 An evaluation of myeloperoxidase-mediated bio-activation of NSAIDs in promyelocytic leukemia (HL-60) cells for potential cytotoxic selectivity. Toxicol Lett. 2017 Oct 5;280:48-56.
529 Differentiation between stoichiometric and anticatalytic antioxidant properties of benzoic acid analogues: a structure/redox potential relationship study. Chem Biol Interact. 2013 Nov 25;206(2):194-203.
530 Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2716-23.
531 Effect of anti-rheumatic drugs on the release of lysosomal enzymes from human leukocytes. Z Rheumatol. 1984 Jan-Feb;43(1):23-6.
532 Benzodithiophenes induce differentiation and apoptosis in human leukemia cells. Cancer Res. 2005 Sep 1;65(17):7847-55. doi: 10.1158/0008-5472.CAN-05-1053.
533 Inhibition of oxidation activity of myeloperoxidase (MPO) by propylthiouracil (PTU) and anti-MPO antibodies from patients with PTU-induced vasculitis. Clin Immunol. 2007 Feb;122(2):187-93. doi: 10.1016/j.clim.2006.09.011. Epub 2006 Oct 27.
534 ?-adrenoceptors and muscarinic receptors mediate opposing effects on endothelin-1 expression in human lung fibroblasts. Eur J Pharmacol. 2012 Sep 15;691(1-3):218-24. doi: 10.1016/j.ejphar.2012.07.002. Epub 2012 Jul 13.
535 Induction of endothelin-1 expression by oxidative stress in vascular smooth muscle cells. Cardiovasc Pathol. 2001 Nov-Dec;10(6):311-5. doi: 10.1016/s1054-8807(01)00095-3.
536 [Effect of simvastatin on endothelin-1 expression in endothelial cell cultured hypoxically]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Jan;39(1):72-5.
537 Effects of dietary polyphenols on gene expression in human vascular endothelial cells. Proc Nutr Soc. 2008 Feb;67(1):42-7.
538 Cardiac toxicity of high-dose cyclophosphamide in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation. Int J Hematol. 2007 Jun;85(5):408-14. doi: 10.1532/IJH97.E0620.
539 Different effects of angiotensin converting enzyme inhibitors on endothelin-1 and nitric oxide balance in human vascular endothelial cells: evidence of an oxidant-sensitive pathway. Mediators Inflamm. 2008;2008:305087. doi: 10.1155/2008/305087. Epub 2008 Dec 1.
540 Dicloxacillin and erythromycin at high concentrations increase ICAM-1 expression by endothelial cells: a possible factor in the pathogenesis of infusion phlebitis. J Antimicrob Chemother. 2004 Feb;53(2):174-9. doi: 10.1093/jac/dkh056. Epub 2004 Jan 16.
541 Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. FASEB J. 2012 Apr;26(4):1535-48. doi: 10.1096/fj.11-198184. Epub 2011 Dec 23.
542 The effect of fexofenadine on expression of intercellular adhesion molecule 1 and induction of apoptosis on peripheral eosinophils. Allergy Asthma Proc. 2005 Jul-Aug;26(4):292-8.
543 Antiallergic effects of H1-receptor antagonists. Allergy. 2000;55 Suppl 64:17-27. doi: 10.1034/j.1398-9995.2000.00803.x.
544 Correlation of sICAM-1 and sVCAM-1 level with biochemical, histological and viral findings in chronic hepatitis C after interferon-alpha + ribavirin therapy. Rom J Gastroenterol. 2003 Jun;12(2):91-5.
545 Some non-sensitizers upregulate CD54 expression by activation of the NLRP3 inflammasome in THP-1 cells. J Toxicol Sci. 2019;44(3):213-224. doi: 10.2131/jts.44.213.
546 Dimethyl Fumarate Inhibits the Nuclear Factor B Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. J Biol Chem. 2016 Feb 12;291(7):3639-47. doi: 10.1074/jbc.M115.679704. Epub 2015 Dec 18.
547 Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin-1beta in human tendon-derived cells. A potential mechanism of fluoroquinolone-induced tendinopathy. Arthritis Rheum. 2002 Nov;46(11):3034-40. doi: 10.1002/art.10617.
548 Reduction of synovial sublining layer inflammation and proinflammatory cytokine expression in psoriatic arthritis treated with methotrexate. Arthritis Rheum. 2004 Oct;50(10):3286-95. doi: 10.1002/art.20518.
549 Quercetin inhibits IL-1-induced proliferation and production of MMPs, COX-2, and PGE2 by rheumatoid synovial fibroblast. Inflammation. 2012 Aug;35(4):1585-94. doi: 10.1007/s10753-012-9473-2.
550 Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans: implication for the adverse effects of cyclooxygenase-2 inhibitors. Clin Pharmacol Ther. 2006 Apr;79(4):303-15. doi: 10.1016/j.clpt.2005.12.306.
551 Vascular complications of long-term oestrogen therapy. Front Horm Res. 1977;5:174-91. doi: 10.1159/000401993.
552 Interaction between fenofibrate and warfarin. Ann Pharmacother. 1998 Jul-Aug;32(7-8):765-8. doi: 10.1345/aph.17310.
553 Increased levels of activated factor VII and decreased plasma protein S activity and circulating thrombomodulin during use of oral contraceptives. Thromb Haemost. 1996 Nov;76(5):729-34.
554 Effect of opium addiction on new and traditional cardiovascular risk factors: do duration of addiction and route of administration matter?. Lipids Health Dis. 2008 Nov 3;7:42. doi: 10.1186/1476-511X-7-42.
555 Short-term effects of estrogen, tamoxifen and raloxifene on hemostasis: a randomized-controlled study and review of the literature. Thromb Res. 2005;116(1):1-13. doi: 10.1016/j.thromres.2004.09.014.
556 Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21737-42. doi: 10.1073/pnas.1007863107. Epub 2010 Nov 22.
557 Patterns of some extracellular matrix gene expression are similar in cells from cleft lip-palate patients and in human palatal fibroblasts exposed to diazepam in culture. Toxicology. 2009 Mar 4;257(1-2):10-6. doi: 10.1016/j.tox.2008.12.002. Epub 2008 Dec 9.
558 Imiquimod: a potential weapon against Dupuytren contracture. Med Hypotheses. 2006;66(5):991-2. doi: 10.1016/j.mehy.2005.09.052. Epub 2005 Dec 20.
559 Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells. PLoS One. 2016 Jan 22;11(1):e0147312. doi: 10.1371/journal.pone.0147312. eCollection 2016.
560 The role of simvastatin in the osteogenesis of injectable tissue-engineered bone based on human adipose-derived stromal cells and platelet-rich plasma. Biomaterials. 2010 Jul;31(20):5325-35. doi: 10.1016/j.biomaterials.2010.03.037. Epub 2010 Apr 9.
561 Proliferation of cultured human gingival fibroblasts caused by isradipine, a dihydropyridine-derivative calcium antagonist. Eur J Med Res. 2004 Jun 30;9(6):313-5.
562 The effect of valdecoxib on the production of growth factors evoked by hypoxia and bacterial lipopolysaccharide in HMEC-1 cells. Adv Clin Exp Med. 2013 Nov-Dec;22(6):795-800.
563 Adipogenic Effects and Gene Expression Profiling of Firemaster? 550 Components in Human Primary Preadipocytes. Environ Health Perspect. 2017 Sep 14;125(9):097013. doi: 10.1289/EHP1318.
564 Direct and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes. BMC Immunol. 2006 Nov 21;7:27. doi: 10.1186/1471-2172-7-27.
565 Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC). Front Microbiol. 2015 Dec 22;6:1452. doi: 10.3389/fmicb.2015.01452. eCollection 2015.
566 Glucocorticoids inhibit cell death in ovarian cancer and up-regulate caspase inhibitor cIAP2. Clin Cancer Res. 2005 Sep 1;11(17):6325-32. doi: 10.1158/1078-0432.CCR-05-0182.
567 Immunomodulatory derivative of thalidomide (IMiD CC-4047) induces a shift in lineage commitment by suppressing erythropoiesis and promoting myelopoiesis. Blood. 2005 May 15;105(10):3833-40. doi: 10.1182/blood-2004-03-0828. Epub 2004 Aug 3.
568 Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
569 Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol. 2012 May;57(5):483-90. doi: 10.1016/j.archoralbio.2011.10.007. Epub 2011 Nov 25.
570 Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
571 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
572 Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med. 2000 Jan;161(1):249-56. doi: 10.1164/ajrccm.161.1.9804096.
573 Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
574 Identification of human cell responses to benzene and benzene metabolites. Genomics. 2007 Sep;90(3):324-33.
575 Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents. Leuk Res. 2010 Jul;34(7):917-24. doi: 10.1016/j.leukres.2009.12.002. Epub 2010 Feb 8.
576 Crosstalk between alveolar macrophages and alveolar epithelial cells/fibroblasts contributes to the pulmonary toxicity of gefitinib. Toxicol Lett. 2021 Mar 1;338:1-9. doi: 10.1016/j.toxlet.2020.11.011. Epub 2020 Nov 25.
577 Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients. Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1194-9. doi: 10.1161/01.atv.0000022694.16328.cc.
578 Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFB and AhR and EGFR-ERK pathway. Toxicol Appl Pharmacol. 2011 Sep 1;255(2):138-49.
579 The mutant androgen receptor T877A mediates the proliferative but not the cytotoxic dose-dependent effects of genistein and quercetin on human LNCaP prostate cancer cells. Mol Pharmacol. 2002 Nov;62(5):1027-35. doi: 10.1124/mol.62.5.1027.
580 Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
581 How benzene and its metabolites affect human marrow derived mesenchymal stem cells. Toxicol Lett. 2012 Oct 17;214(2):145-53. doi: 10.1016/j.toxlet.2012.08.015. Epub 2012 Aug 30.
582 Inflammation in methotrexate-induced pulmonary toxicity occurs via the p38 MAPK pathway. Toxicology. 2009 Feb 27;256(3):183-90. doi: 10.1016/j.tox.2008.11.016. Epub 2008 Nov 28.
583 Immune regulatory effects of simvastatin on regulatory T cell-mediated tumour immune tolerance. Clin Exp Immunol. 2010 Aug;161(2):298-305. doi: 10.1111/j.1365-2249.2010.04170.x. Epub 2010 May 18.
584 Quercetin's influence on exercise-induced changes in plasma cytokines and muscle and leukocyte cytokine mRNA. J Appl Physiol (1985). 2007 Nov;103(5):1728-35. doi: 10.1152/japplphysiol.00707.2007. Epub 2007 Aug 23.
585 The effects of 1 month antihypertensive treatment with perindopril, bisoprolol or both on the ex vivo ability of monocytes to secrete inflammatory cytokines. Int J Clin Pharmacol Ther. 2009 Nov;47(11):686-94. doi: 10.5414/cpp47686.
586 Characterization of drug-specific signaling between primary human hepatocytes and immune cells. Toxicol Sci. 2017 Jul 1;158(1):76-89.
587 The differential effects of neuroleptic drugs and PACAP on the expression of BDNF mRNA and protein in a human glioblastoma cell line. Acta Neurobiol Exp (Wars). 2017;77(3):205-213.
588 Tea polyphenols ameliorates neural redox imbalance and mitochondrial dysfunction via mechanisms linking the key circadian regular Bmal1. Food Chem Toxicol. 2017 Dec;110:189-199. doi: 10.1016/j.fct.2017.10.031. Epub 2017 Oct 20.
589 LncRNA SNHG12 ameliorates bupivacaine-induced neurotoxicity by sponging miR-497-5p to upregulate NLRX1. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089001. doi: 10.1177/09603271221089001.
590 Mechanism of arsenic trioxide inhibiting angiogenesis in multiple myeloma. J Huazhong Univ Sci Technolog Med Sci. 2006;26(1):43-6. doi: 10.1007/BF02828035.
591 Lack of uniform platelet activation in patients after ischemic stroke and choice of antiplatelet therapy. Thromb Res. 2004;113(3-4):197-204. doi: 10.1016/j.thromres.2004.03.002.
592 Effect of atorvastatin on circulating proinflammatory T-lymphocyte subsets and soluble CD40 ligand in patients with stable coronary artery disease--a randomized, placebo-controlled study. Am Heart J. 2006 Jan;151(1):139. doi: 10.1016/j.ahj.2005.10.006.
593 Magnitude and time course of platelet inhibition with Aggrenox and Aspirin in patients after ischemic stroke: the AGgrenox versus Aspirin Therapy Evaluation (AGATE) trial. Eur J Pharmacol. 2004 Sep 24;499(3):315-24. doi: 10.1016/j.ejphar.2004.07.114.
594 Additive beneficial effects of fenofibrate combined with candesartan in the treatment of hypertriglyceridemic hypertensive patients. Diabetes Care. 2006 Feb;29(2):195-201. doi: 10.2337/diacare.29.02.06.dc05-1418.
595 Effect of zoledronic acid on oral fibroblasts and epithelial cells: a potential mechanism of bisphosphonate-associated osteonecrosis. Br J Haematol. 2009 Mar;144(5):667-76. doi: 10.1111/j.1365-2141.2008.07504.x. Epub 2008 Nov 20.
596 Eptifibatide in peripheral vascular interventions: results of the Integrilin Reduces Inflammation in Peripheral Vascular Interventions (INFLAME) trial. J Invasive Cardiol. 2006 Jan;18(1):6-12.
597 Benzyl isothiocyanate attenuates the hydrogen peroxide-induced interleukin-13 expression through glutathione S-transferase P induction in T lymphocytic leukemia cells. J Biochem Mol Toxicol. 2018 Jun;32(6):e22054.
598 Alterations in eotaxin, monocyte chemoattractant protein-4, interleukin-5, and interleukin-13 after systemic steroid treatment for nasal polyps. Otolaryngol Head Neck Surg. 2004 Nov;131(5):585-9. doi: 10.1016/j.otohns.2004.05.028.
599 Editor's Highlight: Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues. Toxicol Sci. 2016 Dec;154(2):354-367. doi: 10.1093/toxsci/kfw169. Epub 2016 Sep 7.
600 Inhibition of interleukin-13 gene expression in T cells through GATA-3 pathway by arsenic trioxide. Chin Med J (Engl). 2008 Nov 20;121(22):2346-9.
601 [Effects of beclomethasone dipropionate and budesonide on interleukin-13 induced cytokine release, proliferation and differentiation of the human lung fibroblasts]. Zhonghua Jie He He Hu Xi Za Zhi. 2007 Aug;30(8):599-604.
602 1,25(OH)2-vitamin D3 inhibits proliferation and decreases production of monocyte chemoattractant protein-1, thrombopoietin, VEGF, and angiogenin by human annulus cells in vitro. Spine (Phila Pa 1976). 2008 Apr 1;33(7):755-65. doi: 10.1097/BRS.0b013e3181695d59.
603 Methamphetamine alters the normal progression by inducing cell cycle arrest in astrocytes. PLoS One. 2014 Oct 7;9(10):e109603.
604 Distinct vascular and metabolic effects of different classes of anti-hypertensive drugs. Int J Cardiol. 2010 Apr 1;140(1):73-81. doi: 10.1016/j.ijcard.2008.11.017. Epub 2008 Dec 6.
605 [Quercetin affects leptin and its receptor in human gastric cancer MGC-803 cells and JAK-STAT pathway]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 Jan;28(1):12-6.
606 Leptin production in adipocytes from morbidly obese subjects: stimulation by dexamethasone, inhibition with troglitazone, and influence of gender. J Clin Endocrinol Metab. 2000 Aug;85(8):2678-84. doi: 10.1210/jcem.85.8.6733.
607 Effects of nevirapine and efavirenz on human adipocyte differentiation, gene expression, and release of adipokines and cytokines. Antiviral Res. 2011 Aug;91(2):112-9. doi: 10.1016/j.antiviral.2011.04.018. Epub 2011 May 17.
608 The psychoactive compound of Cannabis sativa, (9)-tetrahydrocannabinol (THC) inhibits the human trophoblast cell turnover. Toxicology. 2015 Aug 6;334:94-103. doi: 10.1016/j.tox.2015.06.005. Epub 2015 Jun 9.
609 Amlodipine improves endothelial function and metabolic parameters in patients with hypertension. Int J Cardiol. 2009 Mar 20;133(1):23-31. doi: 10.1016/j.ijcard.2007.11.058. Epub 2008 Jan 15.
610 The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
611 Comparative effects of raloxifene, tamoxifen and estradiol on human osteoblasts in vitro: estrogen receptor dependent or independent pathways of raloxifene. J Steroid Biochem Mol Biol. 2009 Feb;113(3-5):281-9.
612 Histamine h(4) and h(2) receptors control histamine-induced interleukin-16 release from human CD8(+) T cells. J Pharmacol Exp Ther. 2002 Oct;303(1):300-7. doi: 10.1124/jpet.102.036939.
613 The THP-1 cell toolbox: a new concept integrating the key events of skin sensitization. Arch Toxicol. 2019 Apr;93(4):941-951.
614 Transcriptomics and methylomics of CD4-positive T cells in arsenic-exposed women. Arch Toxicol. 2017 May;91(5):2067-2078. doi: 10.1007/s00204-016-1879-4. Epub 2016 Nov 12.
615 Additive beneficial cardiovascular and metabolic effects of combination therapy with ramipril and candesartan in hypertensive patients. Eur Heart J. 2007 Jun;28(12):1440-7. doi: 10.1093/eurheartj/ehm101. Epub 2007 May 5.
616 Combination of an ACE inhibitor and indapamide improves blood pressure control, but attenuates the beneficial effects of ACE inhibition on plasma adiponectin in patients with essential hypertension. Circ J. 2009 Dec;73(12):2282-7. doi: 10.1253/circj.cj-09-0387. Epub 2009 Sep 29.
617 Role of PML SUMOylation in arsenic trioxide-induced fibrosis in HSCs. Life Sci. 2020 Jun 15;251:117607. doi: 10.1016/j.lfs.2020.117607. Epub 2020 Mar 30.
618 (9)-Tetrahydrocannabinol upregulates fatty acid 2-hydroxylase (FA2H) via PPAR induction: A possible evidence for the cancellation of PPAR/-mediated inhibition of PPAR in MDA-MB-231?cells. Arch Biochem Biophys. 2019 Feb 15;662:219-225. doi: 10.1016/j.abb.2018.12.011. Epub 2018 Dec 13.
619 Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
620 RNAi-mediated knockdown of aldehyde dehydrogenase class-1A1 and class-3A1 is specific and reveals that each contributes equally to the resistance against 4-hydroperoxycyclophosphamide. Cancer Chemother Pharmacol. 2007 Jan;59(1):127-36. doi: 10.1007/s00280-006-0233-6. Epub 2006 Apr 14.
621 Inhibition of aldehyde dehydrogenase-1 and p-glycoprotein-mediated multidrug resistance by curcumin and vitamin D3 increases sensitivity to paclitaxel in breast cancer. Chem Biol Interact. 2020 Jan 5;315:108865. doi: 10.1016/j.cbi.2019.108865. Epub 2019 Oct 16.
622 The interaction of disulfiram and H(2)S metabolism in inhibition of aldehyde dehydrogenase activity and liver cancer cell growth. Toxicol Appl Pharmacol. 2021 Sep 1;426:115642. doi: 10.1016/j.taap.2021.115642. Epub 2021 Jul 6.
623 Quercetin attenuates cell apoptosis of oxidant-stressed SK-N-MC cells while suppressing up-regulation of the defensive element, HIF-1alpha. Neuroscience. 2014 Sep 26;277:780-93.
624 Arsenic trioxide inhibits cell growth and induces apoptosis through inactivation of notch signaling pathway in breast cancer. Int J Mol Sci. 2012;13(8):9627-9641. doi: 10.3390/ijms13089627. Epub 2012 Aug 2.
625 Propranolol inhibits proliferation and invasion of hemangioma-derived endothelial cells by suppressing the DLL4/Notch1/Akt pathway. Chem Biol Interact. 2018 Oct 1;294:28-33. doi: 10.1016/j.cbi.2018.08.018. Epub 2018 Aug 18.
626 NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
627 The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells. J Cell Biochem. 2009 Mar 1;106(4):682-92. doi: 10.1002/jcb.22065.
628 Mebendazole is a potent inhibitor to chemoresistant T cell acute lymphoblastic leukemia cells. Toxicol Appl Pharmacol. 2020 Jun 1;396:115001. doi: 10.1016/j.taap.2020.115001. Epub 2020 Apr 8.
629 Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
630 Arsenic trioxide down-regulates antiapoptotic genes and induces cell death in mycosis fungoides tumors in a mouse model. Ann Oncol. 2008 Aug;19(8):1488-1494. doi: 10.1093/annonc/mdn056. Epub 2008 Mar 17.
631 Targeting activation of specific NF-B subunits prevents stress-dependent atherothrombotic gene expression. Mol Med. 2012 Dec 20;18(1):1375-86. doi: 10.2119/molmed.2012.00282.
632 Efficient intervention of growth and infiltration of primary adult T-cell leukemia cells by an HIV protease inhibitor, ritonavir. Blood. 2006 Jan 15;107(2):716-24. doi: 10.1182/blood-2005-02-0735. Epub 2005 Sep 20.
633 Effect of ellagic acid on the expression of human telomerase reverse transcriptase (hTERT) alpha+beta+ transcript in estrogen receptor-positive MCF-7 breast cancer cells. Clin Biochem. 2009 Sep;42(13-14):1358-62. doi: 10.1016/j.clinbiochem.2009.05.017. Epub 2009 Jun 6.
634 Antiproliferative effects of gefitinib are associated with suppression of E2F-1 expression and telomerase activity. Anticancer Res. 2006 Sep-Oct;26(5A):3387-91.
635 Inhibitory effects of selenium on telomerase activity and hTERT expression in cadmium-transformed 16HBE cells. Biomed Environ Sci. 2007 Aug;20(4):307-12.
636 Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast cancer cells. BMC Cancer. 2010 Jul 22;10:390. doi: 10.1186/1471-2407-10-390.
637 Analysis of telomerase activity and RNA expression in a patient with acute promyelocytic leukemia treated with all-trans retinoic acid. Pediatr Blood Cancer. 2006 Apr;46(4):506-11. doi: 10.1002/pbc.20392.
638 Characterization of the functional and growth properties of long-term cell cultures established from a human somatostatinoma. Endocr Relat Cancer. 2006 Mar;13(1):79-93. doi: 10.1677/erc.1.00988.
639 Characterization of arsenic-induced cytogenetic alterations in acute promyelocytic leukemia cell line, NB4. Med Oncol. 2012 Jun;29(2):1209-16. doi: 10.1007/s12032-011-9946-4. Epub 2011 May 5.
640 Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
641 mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
642 Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
643 Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin. Invest New Drugs. 2011 Oct;29(5):945-52. doi: 10.1007/s10637-010-9450-2. Epub 2010 May 13.
644 Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene. 2005 Sep 15;24(41):6213-21. doi: 10.1038/sj.onc.1208774.
645 Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest. 2009 Jul;27(6):604-12. doi: 10.1080/07357900802337191.
646 Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. Apoptosis. 2006 Sep;11(9):1503-12. doi: 10.1007/s10495-006-8896-3.
647 Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci. 2007 Mar;96(1):101-14.
648 Protective effects of myricitrin against osteoporosis via reducing reactive oxygen species and bone-resorbing cytokines. Toxicol Appl Pharmacol. 2014 Nov 1;280(3):550-60.
649 Acinar cell-specific knockout of the PTHrP gene decreases the proinflammatory and profibrotic responses in pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G533-49. doi: 10.1152/ajpgi.00428.2013. Epub 2014 Jul 17.
650 The effects of particulate wear debris, cytokines, and growth factors on the functions of MG-63 osteoblasts. J Bone Joint Surg Am. 2001 Feb;83(2):201-11. doi: 10.2106/00004623-200102000-00007.
651 Inhibition of systemic sclerosis dermal fibroblast type I collagen production and gene expression by simvastatin. Arthritis Rheum. 2006 Apr;54(4):1298-308. doi: 10.1002/art.21723.
652 Antifibrotic effects of quercetin in primary orbital fibroblasts and orbital fat tissue cultures of Graves' orbitopathy. Invest Ophthalmol Vis Sci. 2012 Aug 31;53(9):5921-9. doi: 10.1167/iovs.12-9646.
653 p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
654 Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
655 Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
656 Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
657 Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
658 Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. Nucleic Acids Res. 2009 Jan;37(1):78-95. doi: 10.1093/nar/gkn910. Epub 2008 Nov 16.
659 Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
660 Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
661 Estrogen utilization of IGF-1-R and EGF-R to signal in breast cancer cells. J Steroid Biochem Mol Biol. 2010 Feb 28;118(4-5):219-30. doi: 10.1016/j.jsbmb.2009.09.018. Epub 2009 Oct 6.
662 Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib. Clin Cancer Res. 2007 May 1;13(9):2795-803. doi: 10.1158/1078-0432.CCR-06-2077.
663 Simvastatin inhibits the proliferation of human prostate cancer PC-3 cells via down-regulation of the insulin-like growth factor 1 receptor. Biochem Biophys Res Commun. 2008 Jul 25;372(2):356-61. doi: 10.1016/j.bbrc.2008.05.043. Epub 2008 May 19.
664 Arsenic trioxide and cisplatin synergism increase cytotoxicity in human ovarian cancer cells: therapeutic potential for ovarian cancer. Cancer Sci. 2009 Dec;100(12):2459-64.
665 Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
666 Protective role of HO-1 for alcohol-dependent liver damage. Dig Dis. 2010;28(6):792-8. doi: 10.1159/000324287. Epub 2011 Apr 27.
667 High selenium status in individuals exposed to arsenic through coal-burning in Shaanxi (PR of China) modulates antioxidant enzymes, heme oxygenase-1 and DNA damage. Clin Chim Acta. 2010 Sep 6;411(17-18):1312-8.
668 Combination treatment with arsenic trioxide and sulindac enhances apoptotic cell death in lung cancer cells via activation of oxidative stress and mitogen-activated protein kinases. Oncol Rep. 2008 Aug;20(2):379-84.
669 Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013 Apr 25;203(2):412-22. doi: 10.1016/j.cbi.2013.03.011. Epub 2013 Mar 22.
670 Cigarette smoke and asbestos activate poly-ADP-ribose polymerase in alveolar epithelial cells. J Investig Med. 2001 Jan;49(1):68-76. doi: 10.2310/6650.2001.34092.
671 The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. doi: 10.1002/(sici)1099-0461(1999)13:6<338::aid-jbt8>3.0.co;2-7.
672 Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
673 Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
674 Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells. Clin Exp Immunol. 2007 May;148(2):288-95. doi: 10.1111/j.1365-2249.2007.03335.x. Epub 2007 Feb 7.
675 Quercetin suppresses pancreatic ductal adenocarcinoma progression via inhibition of SHH and TGF-/Smad signaling pathways. Cell Biol Toxicol. 2021 Jun;37(3):479-496. doi: 10.1007/s10565-020-09562-0. Epub 2020 Oct 17.
676 Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms. PLoS One. 2011;6(11):e27306. doi: 10.1371/journal.pone.0027306. Epub 2011 Nov 8.
677 Arsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulation. PLoS One. 2013 Jul 8;8(7):e69466. doi: 10.1371/journal.pone.0069466. Print 2013.
678 DNA methylation inhibits p53-mediated survivin repression. Oncogene. 2009 May 14;28(19):2046-50. doi: 10.1038/onc.2009.62. Epub 2009 Apr 13.
679 Discovery of molecular mechanisms of neuroprotection using cell-based bioassays and oligonucleotide arrays. Physiol Genomics. 2002 Oct 29;11(2):45-52. doi: 10.1152/physiolgenomics.00064.2002.
680 Levamisole induced apoptosis in cultured vascular endothelial cells. Br J Pharmacol. 2000 Dec;131(8):1577-83.
681 G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J Biol Chem. 1993 Apr 15;268(11):8298-308.
682 Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
683 Synthesis and antitumor evaluation of nitrovinyl biphenyls: anticancer agents based on allocolchicines. ChemMedChem. 2011 May 2;6(5):859-68. doi: 10.1002/cmdc.201100019. Epub 2011 Apr 6.
684 Effect of all-trans retinoic acid on sodium/iodide symporter expression, radioiodine uptake and gene expression profiles in a human anaplastic thyroid carcinoma cell line. Nucl Med Biol. 2006 Oct;33(7):875-82. doi: 10.1016/j.nucmedbio.2006.07.004.
685 Computational discovery of niclosamide ethanolamine, a repurposed drug candidate that reduces growth of hepatocellular carcinoma cells initro and in mice by inhibiting cell division cycle 37 signaling. Gastroenterology. 2017 Jun;152(8):2022-2036.
686 Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature. 2010 Sep 30;467(7315):596-9. doi: 10.1038/nature09454.
687 Rap1/B-Raf signaling is activated in neuroendocrine tumors of the digestive tract and Raf kinase inhibition constitutes a putative therapeutic target. Neuroendocrinology. 2007;85(1):45-53. doi: 10.1159/000100508. Epub 2007 Mar 5.
688 Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes. Arch Toxicol. 2018 Jan;92(1):371-381.
689 Enhanced cytotoxicity of bioreductive antitumor agents with dimethyl fumarate in human glioblastoma cells. Anticancer Drugs. 2005 Feb;16(2):167-74.
690 Growth-suppressive effect of non-steroidal anti-inflammatory drugs on 11 colon-cancer cell lines and fluorescence differential display of genes whose expression is influenced by sulindac. Int J Cancer. 2000 Dec 15;88(6):873-80. doi: 10.1002/1097-0215(20001215)88:6<873::aid-ijc6>3.0.co;2-b.
691 Simvastatin protects dopaminergic neurons against MPP+-induced oxidative stress and regulates the endogenous anti-oxidant system through ERK. Cell Physiol Biochem. 2018;51(4):1957-1968.
692 P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
693 Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin. Toxicol Lett. 2001 Feb 3;119(1):49-57.
694 Promotion of the articular cartilage proteoglycan degradation by T-2 toxin and selenium protective effect. J Zhejiang Univ Sci B. 2008 Jan;9(1):22-33. doi: 10.1631/jzus.B071322.
695 Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44. J Biol Chem. 2011 Apr 1;286(13):11314-27. doi: 10.1074/jbc.M110.193714. Epub 2011 Jan 3.
696 Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
697 Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. J Toxicol Sci. 2015 Jun;40(3):329-38. doi: 10.2131/jts.40.329.
698 Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Implication for its cardiac developmental toxicity. Toxicology. 2020 Apr 15;435:152422. doi: 10.1016/j.tox.2020.152422. Epub 2020 Feb 26.
699 Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. Bioorg Med Chem. 2007 Jul 15;15(14):4863-75. doi: 10.1016/j.bmc.2007.04.057. Epub 2007 May 3.
700 Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochem Pharmacol. 2011 Feb 15;81(4):510-7. doi: 10.1016/j.bcp.2010.11.014. Epub 2010 Nov 27.
701 Actinomycin D inhibits the expression of the cystine/glutamate transporter xCT via attenuation of CD133 synthesis in CD133(+) HCC. Chem Biol Interact. 2019 Aug 25;309:108713. doi: 10.1016/j.cbi.2019.06.026. Epub 2019 Jun 19.
702 Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells. Ann Hematol. 2010 Nov;89(11):1115-24. doi: 10.1007/s00277-010-0988-z. Epub 2010 May 25.
703 The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
704 The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. DNA Repair (Amst). 2004 Mar 4;3(3):235-44. doi: 10.1016/j.dnarep.2003.10.014.
705 Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Mol Cell Biochem. 2010 Nov;344(1-2):173-84. doi: 10.1007/s11010-010-0540-4. Epub 2010 Jul 25.
706 DHT and testosterone, but not DHEA or E2, differentially modulate IGF-I, IGFBP-2, and IGFBP-3 in human prostatic stromal cells. Am J Physiol Endocrinol Metab. 2006 May;290(5):E952-60. doi: 10.1152/ajpendo.00451.2005. Epub 2005 Dec 20.
707 Cannabinoid receptor type I modulates alcohol-induced liver fibrosis. Mol Med. 2011;17(11-12):1285-94. doi: 10.2119/molmed.2011.00149. Epub 2011 Aug 19.
708 Cannabinoid Type 1 Receptors Are Upregulated During Acute Activation of Brown Adipose Tissue. Diabetes. 2018 Jul;67(7):1226-1236. doi: 10.2337/db17-1366. Epub 2018 Apr 12.
709 Regulation of opioid and cannabinoid receptor genes in human neuroblastoma and T cells by the epigenetic modifiers trichostatin A and 5-aza-2'-deoxycytidine. Neuroimmunomodulation. 2012;19(3):180-6. doi: 10.1159/000331474. Epub 2012 Jan 18.
710 Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells. Biol Chem. 2006 Dec;387(12):1629-33. doi: 10.1515/BC.2006.203.
711 Carvedilol prevents epinephrine-induced apoptosis in human coronary artery endothelial cells: modulation of Fas/Fas ligand and caspase-3 pathway. Cardiovasc Res. 2000 Feb;45(3):788-94. doi: 10.1016/s0008-6363(99)00369-7.
712 Regulatory role of KEAP1 and NRF2 in PPAR expression and chemoresistance in human non-small-cell lung carcinoma cells. Free Radic Biol Med. 2012 Aug 15;53(4):758-68. doi: 10.1016/j.freeradbiomed.2012.05.041. Epub 2012 Jun 7.
713 Non-nutritional sweeteners effects on endothelial vascular function. Toxicol In Vitro. 2020 Feb;62:104694. doi: 10.1016/j.tiv.2019.104694. Epub 2019 Oct 23.
714 Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
715 Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
716 Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
717 Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer. 2006 Mar 15;118(6):1370-80. doi: 10.1002/ijc.21537.
718 Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
719 Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1. J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. doi: 10.1124/jpet.104.071332. Epub 2004 Jul 19.
720 Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Res Treat. 2010 Feb;119(3):575-91. doi: 10.1007/s10549-009-0355-8. Epub 2009 Mar 15.
721 Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. Int Arch Allergy Immunol. 2011;155(1):38-51. doi: 10.1159/000318720. Epub 2010 Nov 25.
722 SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
723 Curcumin inhibits hypoxia-inducible factor-1 by degrading aryl hydrocarbon receptor nuclear translocator: a mechanism of tumor growth inhibition. Mol Pharmacol. 2006 Nov;70(5):1664-71. doi: 10.1124/mol.106.025817. Epub 2006 Jul 31.
724 Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2. Toxicol In Vitro. 2011 Apr;25(3):671-83.
725 Omeprazole inhibits pancreatic cancer cell invasion through a nongenomic aryl hydrocarbon receptor pathway. Chem Res Toxicol. 2015 May 18;28(5):907-18.
726 Ligand-independent activation of AhR by hydroquinone mediates benzene-induced hematopoietic toxicity. Chem Biol Interact. 2022 Mar 1;355:109845. doi: 10.1016/j.cbi.2022.109845. Epub 2022 Feb 4.
727 Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
728 A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
729 The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
730 Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
731 Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol Rep. 2006 Jun;15(6):1453-60.
732 Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol. 2008 Jun;46(6):2042-53. doi: 10.1016/j.fct.2008.01.049. Epub 2008 Feb 7.
733 Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenase. J Biol Chem. 2013 Oct 4;288(40):28792-800. doi: 10.1074/jbc.M113.491365. Epub 2013 Aug 12.
734 Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells. J Biol Chem. 2000 Jan 7;275(1):605-12. doi: 10.1074/jbc.275.1.605.
735 Cloning and pharmacological characterization of the dog cannabinoid CB?receptor. Eur J Pharmacol. 2011 Nov 1;669(1-3):24-31. doi: 10.1016/j.ejphar.2011.08.002. Epub 2011 Aug 19.
736 hiPSC-Based Model of Prenatal Exposure to Cannabinoids: Effect on Neuronal Differentiation. Front Mol Neurosci. 2020 Jul 6;13:119. doi: 10.3389/fnmol.2020.00119. eCollection 2020.
737 Comparison of protective effect of ascorbic acid on redox and endocannabinoid systems interactions in in vitro cultured human skin fibroblasts exposed to UV radiation and hydrogen peroxide. Arch Dermatol Res. 2017 May;309(4):285-303. doi: 10.1007/s00403-017-1729-0. Epub 2017 Mar 11.
738 Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation. Cancer Res. 2006 Jul 1;66(13):6615-21. doi: 10.1158/0008-5472.CAN-05-4566.
739 Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
740 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
741 Sulindac suppresses beta-catenin expression in human cancer cells. Eur J Pharmacol. 2008 Mar 31;583(1):26-31. doi: 10.1016/j.ejphar.2007.12.034. Epub 2008 Feb 5.
742 Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation. Mol Cell Endocrinol. 2012 Jan 2;348(1):260-9. doi: 10.1016/j.mce.2011.09.002. Epub 2011 Sep 6.
743 Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib. Leuk Res. 2008 Nov;32(11):1674-83. doi: 10.1016/j.leukres.2008.03.039. Epub 2008 May 15.
744 Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene. 2006 Oct 19;25(49):6447-56. doi: 10.1038/sj.onc.1209658. Epub 2006 Jul 31.
745 Benzene metabolite hydroquinone induces apoptosis of bone marrow mononuclear cells through inhibition of -catenin signaling. Toxicol In Vitro. 2018 Feb;46:361-369. doi: 10.1016/j.tiv.2017.08.018. Epub 2017 Sep 5.
746 Anti-androgen 2-hydroxyflutamide modulates cadherin, catenin and androgen receptor phosphorylation in androgen-sensitive LNCaP and androgen-independent PC3 prostate cancer cell lines acting via PI3K/Akt and MAPK/ERK1/2 pathways. Toxicol In Vitro. 2017 Apr;40:324-335. doi: 10.1016/j.tiv.2017.01.019. Epub 2017 Feb 2.
747 Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia. Clin Cancer Res. 2017 Feb 1;23(3):789-803. doi: 10.1158/1078-0432.CCR-16-0226. Epub 2016 Aug 4.
748 Pro-oxidant induced DNA damage in human lymphoblastoid cells: homeostatic mechanisms of genotoxic tolerance. Toxicol Sci. 2012 Aug;128(2):387-97. doi: 10.1093/toxsci/kfs152. Epub 2012 Apr 26.
749 Differential gene expression of sulindac-treated human breast epithelial cells. Int J Oncol. 2005 Dec;27(6):1727-36.
750 Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression. Eur Neuropsychopharmacol. 2007 Dec;17(12):774-80.
751 Diesel exhaust particulate-induced activation of Stat3 requires activities of EGFR and Src in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2007 Feb;292(2):L422-9. doi: 10.1152/ajplung.00204.2006. Epub 2006 Oct 6.
752 Physapubescin B enhances the sensitivity of gastric cancer cells to trametinib by inhibiting the STAT3 signaling pathway. Toxicol Appl Pharmacol. 2020 Dec 1;408:115273. doi: 10.1016/j.taap.2020.115273. Epub 2020 Oct 6.
753 Sulindac induces apoptosis and inhibits tumor growth in vivo in head and neck squamous cell carcinoma. Neoplasia. 2007 Mar;9(3):192-9. doi: 10.1593/neo.06781.
754 Simvastatin acts as an inhibitor of interferon gamma-induced cycloxygenase-2 expression in human THP-1 cells, but not in murine RAW264.7 cells. Biocell. 2009 Aug;33(2):107-14.
755 Therapeutic potential of cladribine in combination with STAT3 inhibitor against multiple myeloma. BMC Cancer. 2011 Jun 16;11:255. doi: 10.1186/1471-2407-11-255.
756 Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling. Biochem Pharmacol. 2014 Feb 1;87(3):424-34. doi: 10.1016/j.bcp.2013.11.008. Epub 2013 Nov 23.
757 Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
758 [Mechanisms underlying the effect of arsenic trioxide on proliferation inhibition and apoptosis induction in myeloma cell line u266]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Oct;15(5):982-5.
759 Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
760 Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
761 Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
762 Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
763 Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
764 mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
765 Effect of menstrual cycle and hormonal treatment on ki-67 and bcl-2 expression and adenomyosis. Gynecol Endocrinol. 2005 Mar;20(3):127-31. doi: 10.1080/09513590400021086.
766 Mitophagy inhibits proliferation by decreasing cyclooxygenase-2 (COX-2) in arsenic trioxide-treated HepG2 cells. Environ Toxicol Pharmacol. 2016 Jul;45:212-21.
767 Thalidomide suppresses angiogenesis and immune evasion via lncRNA FGD5-AS1/miR-454-3p/ZEB1 axis-mediated VEGFA expression and PD-1/PD-L1 checkpoint in NSCLC. Chem Biol Interact. 2021 Nov 1;349:109652. doi: 10.1016/j.cbi.2021.109652. Epub 2021 Sep 11.
768 Sevoflurane-mediated activation of p38-mitogen-activated stresskinase is independent of apoptosis in Jurkat T-cells. Anesth Analg. 2008 Apr;106(4):1150-60, table of contents. doi: 10.1213/ane.0b013e3181683d37.
769 Apigenin Inhibits Cancer Stem Cell-Like Phenotypes in Human Glioblastoma Cells via Suppression of c-Met Signaling. Phytother Res. 2016 Nov;30(11):1833-1840. doi: 10.1002/ptr.5689. Epub 2016 Jul 29.
770 Arsenic trioxide inhibits Hedgehog, Notch and stem cell properties in glioblastoma neurospheres. Acta Neuropathol Commun. 2014 Mar 31;2:31. doi: 10.1186/2051-5960-2-31.
771 Ivermectin as an inhibitor of cancer stem?like cells. Mol Med Rep. 2018 Feb;17(2):3397-3403. doi: 10.3892/mmr.2017.8231. Epub 2017 Dec 8.
772 Effects and mechanisms of betulinic acid on improving EGFR TKI-resistance of lung cancer cells. Environ Toxicol. 2018 Nov;33(11):1153-1159.
773 The protective effects of liraglutide on AD-like neurodegeneration induced by oxidative stress in human neuroblastoma SH-SY5Y cells. Chem Biol Interact. 2019 Sep 1;310:108688. doi: 10.1016/j.cbi.2019.06.001. Epub 2019 Jun 4.
774 Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis. Oncogene. 2001 Sep 27;20(43):6250-7. doi: 10.1038/sj.onc.1204791.
775 Differential effects of simvastatin and pravastatin on expression of Alzheimer's disease-related genes in human astrocytes and neuronal cells. J Lipid Res. 2009 Oct;50(10):2095-102. doi: 10.1194/jlr.M900236-JLR200. Epub 2009 May 21.
776 Suppression of NF-kappaB and GSK-3beta is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone. Chem Biol Interact. 2010 Oct 6;188(1):75-85. doi: 10.1016/j.cbi.2010.06.001. Epub 2010 Jun 9.
777 NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. J Biol Chem. 2021 Jan-Jun;296:100624. doi: 10.1016/j.jbc.2021.100624. Epub 2021 Apr 2.
778 PLK1 targets NOTCH1 during DNA damage and mitotic progression. J Biol Chem. 2019 Nov 22;294(47):17941-17950. doi: 10.1074/jbc.RA119.009881. Epub 2019 Oct 9.
779 Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis. Endocrinology. 2003 Sep;144(9):3852-9. doi: 10.1210/en.2003-0098.
780 Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. J Biol Chem. 2002 Jul 26;277(30):27393-400. doi: 10.1074/jbc.M201963200. Epub 2002 May 14.
781 Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
782 The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. Exp Eye Res. 2010 Jul;91(1):15-25.
783 Inhibiting AKT signaling pathway with cilostazol and meloxicam synergism for suppressing K562 cells in vitro. J Biochem Mol Toxicol. 2022 Nov;36(11):e23185. doi: 10.1002/jbt.23185. Epub 2022 Aug 3.
784 Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells. Br J Cancer. 2002 Feb 1;86(3):443-8. doi: 10.1038/sj.bjc.6600079.
785 Colchicine-induced apoptosis in human normal liver L-02 cells by mitochondrial mediated pathways. Toxicol In Vitro. 2012 Aug;26(5):649-55. doi: 10.1016/j.tiv.2012.01.024. Epub 2012 Feb 8.
786 Combination of Poly I:C and arsenic trioxide triggers apoptosis synergistically via activation of TLR3 and mitochondrial pathways in hepatocellular carcinoma cells. Cell Biol Int. 2011 Aug;35(8):803-10. doi: 10.1042/CBI20100739.
787 Role of mitochondria in aspirin-induced apoptosis in human gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2005 Oct;289(4):G731-8. doi: 10.1152/ajpgi.00150.2005. Epub 2005 Jun 23.
788 p38 MAPK/PP2Ac/TTP pathway on the connection of TNF- and caspases activation on hydroquinone-induced apoptosis. Carcinogenesis. 2013 Apr;34(4):818-27. doi: 10.1093/carcin/bgs409. Epub 2013 Jan 3.
789 Arsenic trioxide inhibits CXCR4-mediated metastasis by interfering miR-520h/PP2A/NF-B signaling in cervical cancer. Ann Surg Oncol. 2014 Dec;21 Suppl 4:S687-95. doi: 10.1245/s10434-014-3812-5. Epub 2014 Jul 22.
790 Etodolac induces apoptosis and inhibits cell adhesion to bone marrow stromal cells in human myeloma cells. Leuk Res. 2006 Feb;30(2):123-35. doi: 10.1016/j.leukres.2005.06.009. Epub 2005 Jul 25.
791 In vitro antioxidant and antigenotoxic potentials of 3,5-O-di-galloylquinic acid extracted from Myrtus communis leaves and modulation of cell gene expression by H2O2. J Appl Toxicol. 2012 May;32(5):333-41.
792 HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage. FASEB J. 2005 Mar;19(3):476-8. doi: 10.1096/fj.04-2745fje. Epub 2004 Dec 29.
793 Amifostine impairs p53-mediated apoptosis of human myeloid leukemia cells. Mol Cancer Ther. 2003 Sep;2(9):893-900.
794 Quercetin in elimination of tumor initiating stem-like and mesenchymal transformation property in head and neck cancer. Head Neck. 2013 Mar;35(3):413-9. doi: 10.1002/hed.22982. Epub 2012 Mar 16.
795 Altered expression of genes identified in rats with prostatic chronic inflammation in a prostate spheroid model treated by estradiol/testosterone. J Toxicol Sci. 2021;46(11):515-523. doi: 10.2131/jts.46.515.
796 Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
797 Effects of Exposure to Acetaminophen and Ibuprofen on Fetal Germ Cell Development in Both Sexes in Rodent and Human Using Multiple Experimental Systems. Environ Health Perspect. 2018 Apr 16;126(4):047006. doi: 10.1289/EHP2307.
798 Prevention of deoxycholate-induced gastric apoptosis by aspirin: roles of NF-kappaB and PKC signaling. J Surg Res. 2008 Mar;145(1):66-73. doi: 10.1016/j.jss.2007.04.039. Epub 2007 Jul 20.
799 Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells. Immunology. 2007 May;121(1):71-81. doi: 10.1111/j.1365-2567.2006.02539.x.
800 Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells. Eur J Pharmacol. 2010 Jun 10;635(1-3):219-26. doi: 10.1016/j.ejphar.2010.02.044. Epub 2010 Mar 20.
801 Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death. Mol Pharmacol. 2005 May;67(5):1808-17. doi: 10.1124/mol.104.005769. Epub 2005 Feb 9.
802 Role of BAX in the apoptotic response to anticancer agents. Science. 2000 Nov 3;290(5493):989-92. doi: 10.1126/science.290.5493.989.
803 Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
804 PTCH mutations in basal cell carcinomas from azathioprine-treated organ transplant recipients. Br J Cancer. 2008 Oct 21;99(8):1276-84. doi: 10.1038/sj.bjc.6604665.
805 Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells. Carcinogenesis. 2005 May;26(5):883-91. doi: 10.1093/carcin/bgi036. Epub 2005 Feb 10.
806 Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis. Br J Cancer. 2011 Apr 12;104(8):1278-87. doi: 10.1038/bjc.2011.84.
807 Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells. Mol Cancer. 2011 Jul 31;10:95. doi: 10.1186/1476-4598-10-95.
808 The anti-cancer drug gefitinib accelerates Fas-mediated apoptosis by enhancing caspase-8 activation in cancer cells. J Toxicol Sci. 2019;44(6):435-440. doi: 10.2131/jts.44.435.
809 Melatonin enhances hydrogen peroxide-induced apoptosis in human promyelocytic leukaemia HL-60 cells. Mol Cell Biochem. 2011 Jul;353(1-2):167-76. doi: 10.1007/s11010-011-0783-8. Epub 2011 Mar 23.
810 Pituitary specific retinoid-X receptor ligand interactions with thyroid hormone receptor signaling revealed by high throughput reporter and endogenous gene responses. Toxicol In Vitro. 2015 Oct;29(7):1609-18. doi: 10.1016/j.tiv.2015.06.018. Epub 2015 Jun 19.
811 White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol. 2015 Jan;17(1):57-67. doi: 10.1038/ncb3075. Epub 2014 Dec 8.
812 Down-regulation of Sonic hedgehog signaling pathway activity is involved in 5-fluorouracil-induced apoptosis and motility inhibition in Hep3B cells. Acta Biochim Biophys Sin (Shanghai). 2008 Sep;40(9):819-29.
813 Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
814 Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease. J Neurosci. 2016 Jun 8;36(23):6332-51. doi: 10.1523/JNEUROSCI.0426-16.2016.
815 P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation. Food Chem Toxicol. 2016 Feb;88:1-12. doi: 10.1016/j.fct.2015.12.004. Epub 2015 Dec 11.
816 Identification of recurrent SMO and BRAF mutations in ameloblastomas. Nat Genet. 2014 Jul;46(7):722-5. doi: 10.1038/ng.2986. Epub 2014 May 25.
817 Methylparaben stimulates tumor initiating cells in ER+ breast cancer models. J Appl Toxicol. 2017 Apr;37(4):417-425. doi: 10.1002/jat.3374. Epub 2016 Sep 1.
818 Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
819 Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
820 Estrogen receptor alpha (ER)-mediated coregulator binding and gene expression discriminates the toxic ER agonist diethylstilbestrol (DES) from the endogenous ER agonist 17-estradiol (E2). Cell Biol Toxicol. 2020 Oct;36(5):417-435. doi: 10.1007/s10565-020-09516-6. Epub 2020 Feb 22.
821 Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor alpha signalling and results in tamoxifen insensitive proliferation. BMC Cancer. 2014 Apr 23;14:283.
822 Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
823 Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosis. Chem Biol Interact. 2008 Jan 10;171(1):57-66. doi: 10.1016/j.cbi.2007.08.009. Epub 2007 Aug 19.
824 Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-B and matrix metalloproteinase-2/-9 signaling pathways. Anticancer Res. 2013 May;33(5):1941-50.
825 Activation of cannabinoid receptors promote periodontal cell adhesion and migration. J Clin Periodontol. 2019 Dec;46(12):1264-1272. doi: 10.1111/jcpe.13190. Epub 2019 Oct 22.
826 Monomeric and oligomeric flavanols are agonists of membrane androgen receptors. Exp Cell Res. 2005 Oct 1;309(2):329-39. doi: 10.1016/j.yexcr.2005.06.011.
827 Disruption of FAK signaling: a side mechanism in cytotoxicity. Toxicology. 2008 Mar 12;245(1-2):1-10. doi: 10.1016/j.tox.2007.12.003. Epub 2007 Dec 15.
828 Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
829 Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. Mol Cancer. 2010 Aug 20;9:220.
830 Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway. J Biochem Mol Toxicol. 2023 Jun;37(6):e23328. doi: 10.1002/jbt.23328. Epub 2023 Feb 19.
831 Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
832 Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2015 Mar;35(3):1063-76. doi: 10.1111/liv.12626. Epub 2014 Jul 30.
833 Nuclear proteome analysis of cisplatin-treated HeLa cells. Mutat Res. 2010 Sep 10;691(1-2):1-8. doi: 10.1016/j.mrfmmm.2010.06.002. Epub 2010 Jun 9.
834 Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators. Cancer Res. 2005 Aug 1;65(15):6593-600. doi: 10.1158/0008-5472.CAN-03-3675.
835 Cannabidiol disrupts apoptosis, autophagy and invasion processes of placental trophoblasts. Arch Toxicol. 2021 Oct;95(10):3393-3406. doi: 10.1007/s00204-021-03122-z. Epub 2021 Jul 24.
836 AMP-activated protein kinase activity is required for vanadate-induced hypoxia-inducible factor 1alpha expression in DU145 cells. Carcinogenesis. 2004 Dec;25(12):2497-507. doi: 10.1093/carcin/bgh253. Epub 2004 Aug 5.
837 Identification of chemical compounds that induce HIF-1alpha activity. Toxicol Sci. 2009 Nov;112(1):153-63.
838 NO-sulindac inhibits the hypoxia response of PC-3 prostate cancer cells via the Akt signalling pathway. Int J Cancer. 2009 Jan 1;124(1):223-32. doi: 10.1002/ijc.23934.
839 Simvastatin stimulates vascular endothelial growth factor production by hypoxia-inducible factor-1alpha upregulation in endothelial cells. J Cardiovasc Pharmacol. 2008 Mar;51(3):267-73. doi: 10.1097/FJC.0b013e3181624b44.
840 Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism. Chem Biol Interact. 2023 Jan 5;369:110278. doi: 10.1016/j.cbi.2022.110278. Epub 2022 Nov 22.
841 SU5416 inhibited VEGF and HIF-1alpha expression through the PI3K/AKT/p70S6K1 signaling pathway. Biochem Biophys Res Commun. 2004 Nov 12;324(2):471-80. doi: 10.1016/j.bbrc.2004.09.082.
842 Bisphenol-A and estradiol exert novel gene regulation in human MCF-7 derived breast cancer cells. Mol Cell Endocrinol. 2004 Jun 30;221(1-2):47-55. doi: 10.1016/j.mce.2004.04.010.
843 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
844 SKI-606 decreases growth and motility of colorectal cancer cells by preventing pp60(c-Src)-dependent tyrosine phosphorylation of beta-catenin and its nuclear signaling. Cancer Res. 2006 Feb 15;66(4):2279-86. doi: 10.1158/0008-5472.CAN-05-2057.
845 Selective activation of Src family kinases and JNK by low levels of chromium(VI). Toxicol Appl Pharmacol. 2003 Aug 1;190(3):214-23. doi: 10.1016/s0041-008x(03)00188-1.
846 Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells. J Biol Chem. 2015 Jun 19;290(25):15799-15811. doi: 10.1074/jbc.M115.641167. Epub 2015 May 11.
847 Mithramycin inhibits human epithelial carcinoma cell proliferation and migration involving downregulation of Eps8 expression. Chem Biol Interact. 2010 Jan 5;183(1):181-6. doi: 10.1016/j.cbi.2009.09.018.
848 The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
849 Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3. Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G910-22. doi: 10.1152/ajpgi.90672.2008. Epub 2009 Jan 22.
850 Analysis of estrogen agonism and antagonism of tamoxifen, raloxifene, and ICI182780 in endometrial cancer cells: a putative role for the epidermal growth factor receptor ligand amphiregulin. J Soc Gynecol Investig. 2005 Oct;12(7):e55-67.
851 Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo. J Invest Dermatol. 2006 Apr;126(4):732-9. doi: 10.1038/sj.jid.5700202.
852 Amphiregulin is a vitamin D3 target gene in squamous cell and breast carcinoma. Biochem Biophys Res Commun. 2001 Mar 9;281(4):1051-6. doi: 10.1006/bbrc.2001.4466.
853 Arsenic trioxide inhibits EMT in hepatocellular carcinoma by promoting lncRNA MEG3 via PKM2. Biochem Biophys Res Commun. 2019 Jun 11;513(4):834-840. doi: 10.1016/j.bbrc.2019.04.081. Epub 2019 Apr 16.
854 Schedule-dependent therapeutic effects of gemcitabine combined with uracil-tegafur in a human pancreatic cancer xenograft model. Pancreas. 2006 Aug;33(2):142-7. doi: 10.1097/01.mpa.0000226882.48204.26.
855 Two distinct molecular mechanisms underlying cytarabine resistance in human leukemic cells. Cancer Res. 2008 Apr 1;68(7):2349-57. doi: 10.1158/0008-5472.CAN-07-5528.
856 Functional role of the polymorphic 647 T/C variant of ENT1 (SLC29A1) and its association with alcohol withdrawal seizures. PLoS One. 2011 Jan 24;6(1):e16331. doi: 10.1371/journal.pone.0016331.
857 Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
858 Impact of selective serotonin reuptake inhibitors on neural crest stem cell formation. Toxicol Lett. 2017 Nov 5;281:20-25. doi: 10.1016/j.toxlet.2017.08.012. Epub 2017 Aug 24.
859 Activation of PPAR and inhibition of cell proliferation reduces key proteins associated with the basal subtype of bladder cancer in As3+-transformed UROtsa cells. PLoS One. 2020 Aug 21;15(8):e0237976. doi: 10.1371/journal.pone.0237976. eCollection 2020.
860 Constitutive gene expression predisposes morphogen-mediated cell fate responses of NT2/D1 and 27X-1 human embryonal carcinoma cells. Stem Cells. 2007 Mar;25(3):771-8. doi: 10.1634/stemcells.2006-0271. Epub 2006 Nov 30.
861 Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
862 Transcriptional repression of IKK by p53 in arsenite-induced GADD45 accumulation and apoptosis. Oncogene. 2019 Jan;38(5):731-746. doi: 10.1038/s41388-018-0478-7. Epub 2018 Sep 3.
863 Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long-term to Zidovudine. Environ Mol Mutagen. 2007 Apr-May;48(3-4):179-89. doi: 10.1002/em.20245.
864 Small-scale immunopurification of cytochrome c oxidase for a high-throughput multiplexing analysis of enzyme activity and amount. Biotechnol Appl Biochem. 2007 Dec;48(Pt 4):167-78. doi: 10.1042/BA20060223.
865 Enhanced levels of several mitochondrial mRNA transcripts and mitochondrial superoxide production during ethinyl estradiol-induced hepatocarcinogenesis and after estrogen treatment of HepG2 cells. Carcinogenesis. 1998 Dec;19(12):2187-93. doi: 10.1093/carcin/19.12.2187.
866 An increase of cytochrome C oxidase mediated disruption of gemcitabine incorporation into DNA in a resistant KB clone. Biochem Pharmacol. 2007 Jun 15;73(12):1927-38. doi: 10.1016/j.bcp.2007.03.014. Epub 2007 Mar 20.
867 Resveratrol induces apoptosis and alters gene expression in human fibrosarcoma cells. Anticancer Res. 2015 Feb;35(2):767-74.
868 High-throughput data integration of RNA-miRNA-circRNA reveals novel insights into mechanisms of benzo[a]pyrene-induced carcinogenicity. Nucleic Acids Res. 2015 Mar 11;43(5):2525-34. doi: 10.1093/nar/gkv115. Epub 2015 Feb 17.
869 Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer. Endocr Relat Cancer. 2011 Apr 28;18(3):333-45. doi: 10.1530/ERC-10-0262. Print 2011 Jun.
870 Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Arthritis Rheum. 2012 Jun;64(6):1780-9. doi: 10.1002/art.34342. Epub 2011 Dec 19.
871 Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. Melanoma Res. 2008 Apr;18(2):85-94. doi: 10.1097/CMR.0b013e3282f60097.
872 Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. Biochem Pharmacol. 2001 May 15;61(10):1205-15. doi: 10.1016/s0006-2952(01)00583-4.
873 Fluoxetine mediates G0/G1 arrest by inducing functional inhibition of cyclin dependent kinase subunit (CKS)1. Biochem Pharmacol. 2008 May 15;75(10):1924-34. doi: 10.1016/j.bcp.2008.02.013. Epub 2008 Feb 17.
874 Induction mechanism of apoptosis by troglitazone through peroxisome proliferator-activated receptor-gamma in gastric carcinoma cells. Anticancer Res. 2003 Jan-Feb;23(1A):267-73.
875 Down-regulation of CD44 contributes to the differentiation of HL-60 cells induced by ATRA or HMBA. Cell Mol Immunol. 2007 Feb;4(1):59-63.
876 Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
877 Down-regulation of HER-2 expression in human breast cancer cell HBC-4 and ZR75-1 by nitrogen-mustard-N-oxide. Kobe J Med Sci. 2007;53(4):135-42.
878 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
879 Epidermal growth factor receptor activity determines response of colorectal cancer cells to gefitinib alone and in combination with chemotherapy. Clin Cancer Res. 2005 Oct 15;11(20):7480-9. doi: 10.1158/1078-0432.CCR-05-0328.
880 Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-kappaB activity. Toxicol Sci. 2002 Apr;66(2):233-43. doi: 10.1093/toxsci/66.2.233.
881 ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2007 May;6(5):1579-87. doi: 10.1158/1535-7163.MCT-06-0814.
882 Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. Cancer Res. 2002 Nov 1;62(21):6006-10.
883 Arsenic trioxide inhibits translation of mRNA of bcr-abl, resulting in attenuation of Bcr-Abl levels and apoptosis of human leukemia cells. Cancer Res. 2003 Nov 15;63(22):7950-8.
884 Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):117-27.
885 Role of HER-2/neu signaling in sensitivity to tumor necrosis factor-related apoptosis-inducing ligand: enhancement of TRAIL-mediated apoptosis by amiloride. J Cell Biochem. 2005 Oct 1;96(2):376-89. doi: 10.1002/jcb.20512.
886 Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation. EMBO Rep. 2007 Apr;8(4):394-400. doi: 10.1038/sj.embor.7400909. Epub 2007 Feb 23.
887 Changes in gene expressions elicited by physiological concentrations of genistein on human endometrial cancer cells. Mol Carcinog. 2006 Oct;45(10):752-63.
888 Oxidative stress in kidney transplant patients with calcineurin inhibitor-induced hypertension: effect of ramipril. J Cardiovasc Pharmacol. 2002 Oct;40(4):625-31.
889 Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
890 Antiestrogens induce transforming growth factor beta-mediated immunosuppression in breast cancer. Cancer Res. 2010 Feb 15;70(4):1314-22. doi: 10.1158/0008-5472.CAN-09-3292. Epub 2010 Feb 9.
891 PPAR-alpha ligands inhibit H2O2-mediated activation of transforming growth factor-beta1 in human mesangial cells. Antioxid Redox Signal. 2002 Dec;4(6):877-84. doi: 10.1089/152308602762197416.
892 Cytokine abnormalities in a patient with eosinophilic fasciitis. Ann Allergy Asthma Immunol. 2003 Apr;90(4):452-5. doi: 10.1016/S1081-1206(10)61832-7.
893 Ciprofloxacin decreases survival in HT-29 cells via the induction of TGF-beta1 secretion and enhances the anti-proliferative effect of 5-fluorouracil. Br J Pharmacol. 2009 Jun;157(3):362-70. doi: 10.1111/j.1476-5381.2009.00161.x. Epub 2009 Apr 9.
894 Enhanced apoptosis and transforming growth factor-beta1 expression in colorectal adenomas and carcinomas after Sulindac therapy. Dis Colon Rectum. 2001 Jul;44(7):1008-15. doi: 10.1007/BF02235490.
895 The G Protein-Coupled Estrogen Receptor Agonist G-1 Inhibits Nuclear Estrogen Receptor Activity and Stimulates Novel Phosphoproteomic Signatures. Toxicol Sci. 2016 Jun;151(2):434-46. doi: 10.1093/toxsci/kfw057. Epub 2016 Mar 29.
896 The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel. BMC Med Genomics. 2010 Aug 13;3:37. doi: 10.1186/1755-8794-3-37.
897 Quantitative proteomics and transcriptomics addressing the estrogen receptor subtype-mediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein. Mol Cell Proteomics. 2011 Jan;10(1):M110.002170.
898 Effects of metformin and pioglitazone combination on apoptosis and AMPK/mTOR signaling pathway in human anaplastic thyroid cancer cells. J Biochem Mol Toxicol. 2020 Oct;34(10):e22547. doi: 10.1002/jbt.22547. Epub 2020 Jun 26.
899 Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors. J Med Chem. 2017 Feb 23;60(4):1262-1271. doi: 10.1021/acs.jmedchem.6b00990. Epub 2016 Dec 21.