Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQBEYX)

Drug Name
PHENCYCLIDINE Drug Info
Synonyms
1-(1-Phenylcyclohexyl)piperidine; Angel dust; Dust; PCP (Anesthetic); Fenciclidina; Phencyclidinum; Supergrass; Cadillac; Surfer; Crystal; Tranks; Whack; Zombie dust; Magic mist; Busy bee; Piperidine, 1-(1-phenylcyclohexyl)-; Elephant tranquilizer; 1977/10/1; Superweed; Superjoint; Cycline; Sherman; Cyclones; Scuffle; Snorts; Cl-395; Sheets; Selma; Peace; Aurora borealis; Embalming fluid; Pits; Goon; Mist; Crystal joints; Wobble weed; Rocket fuel; Horse tracks; Whacky weed; Monkey dust; Killer weed; Peace weed; Peace pill
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
6468
ChEBI ID
CHEBI:8058
CAS Number
CAS 77-10-1
TTD Drug ID
DMQBEYX
VARIDT Drug ID
DR00661

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Patented Agent(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Glutamate receptor ionotropic NMDA 2A (NMDAR2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glycine DMIOZ29 Allergic rhinitis CA08.0 Approved [7]
NBQX DMPHZI5 Neurological disorder 6B60 Phase 1 [8]
YM-90K DMWRT4L Convulsion 8A68.Z Discontinued in Phase 2 [9]
SPERMINE DMD4BFY N. A. N. A. Terminated [10]
L-689560 DMCVY4U Neurodegenerative disorder 8A20-8A23 Terminated [11]
L-698544 DMLRBN1 Alzheimer disease 8A20 Terminated [12]
DIZOCILPINE DMMGYXR Cerebrovascular ischaemia 8B1Z Terminated [13]
RPR-104632 DM9L50N N. A. N. A. Terminated [14]
L-698532 DMO9HM7 Neurological disorder 6B60 Terminated [15]
L-695902 DMT1DNS N. A. N. A. Terminated [12]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Glutamate receptor ionotropic NMDA 1 (NMDAR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cycloserine DMT1I52 Bacterial infection 1A00-1C4Z Approved [16]
D-Serine DM3YH4I N. A. N. A. Phase 4 [17]
ELIPRODIL DMIOGZM Multiple sclerosis 8A40 Phase 2 [18]
NBQX DMPHZI5 Neurological disorder 6B60 Phase 1 [8]
YM-90K DMWRT4L Convulsion 8A68.Z Discontinued in Phase 2 [9]
SPERMINE DMD4BFY N. A. N. A. Terminated [10]
L-689560 DMCVY4U Neurodegenerative disorder 8A20-8A23 Terminated [19]
L-698544 DMLRBN1 Alzheimer disease 8A20 Terminated [12]
DIZOCILPINE DMMGYXR Cerebrovascular ischaemia 8B1Z Terminated [13]
RPR-104632 DM9L50N N. A. N. A. Terminated [14]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Glutamate receptor ionotropic NMDA 2B (NMDAR2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Alpha 1-PI DMXC1K9 Alpha-1 antitrypsin deficiency 5C5A Approved [20]
ELIPRODIL DMIOGZM Multiple sclerosis 8A40 Phase 2 [18]
CP-101,606 DMIU19E Parkinson disease 8A00.0 Phase 2 [21]
CERC-301 DMSABRI Major depressive disorder 6A70.3 Phase 2 [22]
RGH-896 DMCHZAN Peripheral neuropathy 8C0Z Phase 2 [23]
MIJ821 DMN45RI Major depressive disorder 6A70.3 Phase 2 [24]
NBQX DMPHZI5 Neurological disorder 6B60 Phase 1 [8]
Neu-2000 DMNJTLC Cardiac arrest MC82 Phase 1 [25]
EVT100 DMAKWQD Major depressive disorder 6A70.3 Phase 1 [26]
YM-90K DMWRT4L Convulsion 8A68.Z Discontinued in Phase 2 [9]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic cation transporter 1 (SLC22A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [27]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [28]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [29]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [30]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [31]
Verapamil DMA7PEW Angina pectoris BA40 Approved [32]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [33]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [34]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [35]
Propranolol DM79NTF Angina pectoris BA40 Approved [36]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCN family member 1 (CCN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [44]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [46]
Verapamil DMA7PEW Angina pectoris BA40 Approved [47]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [48]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [47]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [49]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [54]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Fructose DM43AN2 Vomiting MD90 Approved [56]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [57]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [58]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [48]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [61]
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [63]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [64]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [65]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [73]
Methotrexate DM2TEOL Anterior urethra cancer Approved [74]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [76]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [77]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCN family member 2 (CCN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [82]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [38]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [83]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [85]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [86]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [88]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [90]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [91]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [92]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [93]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein jagged-1 (JAG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Methotrexate DM2TEOL Anterior urethra cancer Approved [96]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [98]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [102]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [103]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [104]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [105]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [106]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [108]
Quercetin DM3NC4M Obesity 5B81 Approved [63]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [109]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [105]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [110]
Ethacrynic acid DM60QMR Edema MG29 Approved [111]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [112]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [113]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [114]
Estrone DM5T6US Acne vulgaris ED80 Approved [115]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [116]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [117]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [118]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [119]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [120]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [121]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [122]
Fructose DM43AN2 Vomiting MD90 Approved [56]
Ketoprofen DMRKXPT Bursitis Approved [56]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [123]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [104]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [124]
Gefitinib DM15F0X Colon adenocarcinoma Approved [125]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [126]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [127]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-reactive protein (CRP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [56]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [128]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [129]
Quercetin DM3NC4M Obesity 5B81 Approved [130]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [131]
Acalabrutinib DM7GCVW leukaemia 2A60-2B33 Approved [132]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [133]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [134]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [135]
Testosterone DM7HUNW Hot flushes GA30 Approved [136]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [137]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [112]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [138]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [139]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [140]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [141]
Ethacrynic acid DM60QMR Edema MG29 Approved [142]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [143]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [144]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [145]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [38]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [146]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [120]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [147]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [148]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [127]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [149]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [150]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [151]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [152]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [153]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [120]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [58]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [148]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [154]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [155]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [156]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [154]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [157]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [158]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [159]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [86]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [160]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [161]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [162]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [154]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [163]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 24 (CCL24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Arsenic DMTL2Y1 N. A. N. A. Approved [165]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
Milchsaure DM462BT Pruritus EC90 Investigative [167]
Drug(s) Affected By Nucleoside diphosphate kinase, mitochondrial (NME4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Folic Acid DMEMBJC Colorectal carcinoma Approved [171]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [172]
Paclitaxel DMLB81S Breast carcinoma Approved [173]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [174]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [176]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription elongation regulator 1 (TCERG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [177]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [181]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [182]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [183]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [184]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ADAM DEC1 (ADAMDEC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [185]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [186]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [187]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [38]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Menthol DMG2KW7 Back pain ME84.Z Approved [188]
Capsaicin DMGMF6V Back pain ME84.Z Approved [189]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Carbohydrate sulfotransferase 1 (CHST1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [190]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [191]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Arsenic DMTL2Y1 N. A. N. A. Approved [193]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [194]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [195]
Ibrolipim DMOPWSX Hyperlipidaemia 5C80 Phase 2 [196]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [197]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytohesin-interacting protein (CYTIP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Testosterone enanthate DMB6871 N. A. N. A. Approved [198]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [199]
Bortezomib DMNO38U Leukemia Approved [200]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [182]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [201]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [202]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [203]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [204]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sterol O-acyltransferase 2 (SOAT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [205]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [95]
Urethane DM7NSI0 N. A. N. A. Phase 4 [207]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [208]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [209]
BRN-3548355 DM4KXT0 N. A. N. A. Investigative [210]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone acetyltransferase KAT7 (KAT7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [211]
Testosterone DM7HUNW Hot flushes GA30 Approved [136]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [191]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [101]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [212]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [212]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [101]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By L-lactate dehydrogenase A chain (LDHA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [182]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [56]
Etretinate DM2CZFA Keratosis ED56 Approved [213]
Quercetin DM3NC4M Obesity 5B81 Approved [214]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [216]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [217]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [218]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [219]
Methotrexate DM2TEOL Anterior urethra cancer Approved [220]
Quercetin DM3NC4M Obesity 5B81 Approved [221]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [219]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [222]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon gamma (IFNG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [224]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [225]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [226]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [227]
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [232]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [233]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-1 alpha (IL1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [154]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [154]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [127]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [154]
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Quercetin DM3NC4M Obesity 5B81 Approved [234]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [154]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [141]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [235]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [148]
Gefitinib DM15F0X Colon adenocarcinoma Approved [236]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [154]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [155]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [154]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [149]
Selenium DM25CGV N. A. N. A. Approved [237]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [238]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [239]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-X-C motif chemokine 10 (CXCL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [225]
Quercetin DM3NC4M Obesity 5B81 Approved [240]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [141]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [241]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [242]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [243]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [244]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ferritin heavy chain (FTH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [245]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [246]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [247]
Methotrexate DM2TEOL Anterior urethra cancer Approved [220]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [248]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [44]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [249]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metallothionein-2 (MT2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [250]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [251]
Quercetin DM3NC4M Obesity 5B81 Approved [252]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [141]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [253]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [254]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [255]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [249]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Muellerian-inhibiting factor (AMH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [256]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [174]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [257]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [258]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [259]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [260]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catalase (CAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [155]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [261]
Haloperidol DM96SE0 Delirium Approved [56]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [262]
Selenium DM25CGV N. A. N. A. Approved [263]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [264]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [265]
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [266]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [267]
Quercetin DM3NC4M Obesity 5B81 Approved [268]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [141]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [269]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [270]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [271]
Testosterone DM7HUNW Hot flushes GA30 Approved [136]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [272]
Acetylcholine DMDF79Z Cataract 9B10 Approved [273]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [274]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Selenium DM25CGV N. A. N. A. Approved [237]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [275]
Epinephrine DM3KJBC Acute asthma CA23 Approved [276]
Quercetin DM3NC4M Obesity 5B81 Approved [277]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [278]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [131]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [279]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By HLA class I histocompatibility antigen, A alpha chain (HLA-A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [280]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [281]
Allopurinol DMLPAOB Gout FA25 Approved [282]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [283]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [284]
Ticlopidine DMO946V Acute coronary syndrome BA41 Approved [285]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [284]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [286]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [286]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calpain small subunit 1 (CAPNS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Selenium DM25CGV N. A. N. A. Approved [177]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [287]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [211]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [172]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [288]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [290]
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [291]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [292]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [293]
Paclitaxel DMLB81S Breast carcinoma Approved [294]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [295]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [296]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [297]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [298]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metallothionein-1A (MT1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [250]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [299]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [300]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [143]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [301]
Benzoic Acid DMKB9FI Alopecia areata ED70.2 Approved [299]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [299]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [302]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metallothionein-1E (MT1E)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [253]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [300]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [303]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [304]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [172]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [305]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [306]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldehyde dehydrogenase, mitochondrial (ALDH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [307]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [308]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [44]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [309]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [310]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Plasminogen activator inhibitor 2 (SERPINB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [148]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [311]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [312]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [313]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [255]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [314]
Dicloxacillin DM8EU0Z Bacterial infection 1A00-1C4Z Approved [314]
Ergonovine DM0VEC1 Postpartum haemorrhage JA43 Approved [56]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [315]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [316]
Mizolastine DM1FDN8 Allergic rhinitis CA08.0 Approved [317]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [267]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [318]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [319]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [320]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Large ribosomal subunit protein P1 (RPLP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [182]
Paclitaxel DMLB81S Breast carcinoma Approved [321]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [322]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [197]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [323]
Milchsaure DM462BT Pruritus EC90 Investigative [167]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleophosmin (NPM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [324]
Etretinate DM2CZFA Keratosis ED56 Approved [213]
Methotrexate DM2TEOL Anterior urethra cancer Approved [325]
Quercetin DM3NC4M Obesity 5B81 Approved [326]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [327]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Testosterone DM7HUNW Hot flushes GA30 Approved [328]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [328]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [218]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Epoxide hydrolase 1 (EPHX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [329]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [330]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [331]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [332]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [78]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [333]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Complement decay-accelerating factor (CD55)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [235]
Methotrexate DM2TEOL Anterior urethra cancer Approved [334]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [335]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Testosterone DM7HUNW Hot flushes GA30 Approved [136]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock protein HSP 90-beta (HSP90AB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [336]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [324]
Selenium DM25CGV N. A. N. A. Approved [177]
Etretinate DM2CZFA Keratosis ED56 Approved [213]
Quercetin DM3NC4M Obesity 5B81 Approved [326]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [141]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [253]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin alpha-IIb (ITGA2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [338]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [219]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [339]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [338]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [340]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [219]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [341]
Abciximab DMJO6GV Acute disease Approved [56]
Tirofiban DMQG17S Acute coronary syndrome BA41 Approved [56]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Monocyte differentiation antigen CD14 (CD14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [48]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [131]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [342]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [254]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [343]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [344]
Testosterone DM7HUNW Hot flushes GA30 Approved [328]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [345]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-3 (IL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [346]
Ethanol DMDRQZU Chronic pain MG30 Approved [346]
Menthol DMG2KW7 Back pain ME84.Z Approved [188]
Betamethasone Valerate DMMIAXO Dermatological disease DA24.Y Approved [347]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [348]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [349]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [347]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [56]
Famotidine DMRL3AB Gastric ulcer DA60 Approved [56]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Keratin, type II cytoskeletal 7 (KRT7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [46]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [105]
Selenium DM25CGV N. A. N. A. Approved [177]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [311]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [287]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [350]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [351]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [187]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Annexin A5 (ANXA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [352]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [353]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [141]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [143]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Benzatropine DMF7EXL Parkinsonian disorder Approved [66]
Clozapine DMFC71L Schizophrenia 6A20 Approved [66]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD63 antigen (CD63)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [191]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [338]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Clozapine DMFC71L Schizophrenia 6A20 Approved [354]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [355]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [172]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD48 antigen (CD48)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [187]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [182]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [356]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [205]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [357]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
Manganese DMKT129 N. A. N. A. Investigative [358]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Growth-regulated alpha protein (CXCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Selenium DM25CGV N. A. N. A. Approved [237]
Methotrexate DM2TEOL Anterior urethra cancer Approved [220]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [278]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [38]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [311]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [359]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Macrophage colony-stimulating factor 1 (CSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [352]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [360]
Selenium DM25CGV N. A. N. A. Approved [177]
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [330]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [346]
Testosterone DM7HUNW Hot flushes GA30 Approved [328]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein kinase Fgr (FGR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [339]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [211]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [249]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [355]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [288]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [182]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [349]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [361]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [48]
Gefitinib DM15F0X Colon adenocarcinoma Approved [236]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Selenium DM25CGV N. A. N. A. Approved [177]
Etretinate DM2CZFA Keratosis ED56 Approved [213]
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [141]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 3 (CCL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [147]
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [141]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [109]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [362]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [363]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [364]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [365]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [365]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [147]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 60 kDa heat shock protein, mitochondrial (HSPD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [324]
Etretinate DM2CZFA Keratosis ED56 Approved [213]
Methotrexate DM2TEOL Anterior urethra cancer Approved [220]
Quercetin DM3NC4M Obesity 5B81 Approved [366]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [141]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [367]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [368]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [369]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [253]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [370]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [336]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [371]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [372]
Etretinate DM2CZFA Keratosis ED56 Approved [213]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [373]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [374]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [375]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [376]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [377]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase pim-1 (PIM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [148]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [378]
Methotrexate DM2TEOL Anterior urethra cancer Approved [220]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [76]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [379]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [380]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [381]
Selenium DM25CGV N. A. N. A. Approved [382]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [383]
Methotrexate DM2TEOL Anterior urethra cancer Approved [384]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [385]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [386]
Quercetin DM3NC4M Obesity 5B81 Approved [387]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ornithine decarboxylase (ODC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [388]
Methotrexate DM2TEOL Anterior urethra cancer Approved [389]
Quercetin DM3NC4M Obesity 5B81 Approved [390]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [311]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [391]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Propranolol DM79NTF Angina pectoris BA40 Approved [392]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [393]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [49]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Selenium DM25CGV N. A. N. A. Approved [382]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [394]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [395]
Meloxicam DM2AR7L Arthritis FA20 Approved [396]
Methotrexate DM2TEOL Anterior urethra cancer Approved [384]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [39]
Epinephrine DM3KJBC Acute asthma CA23 Approved [397]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Parathyroid hormone-related protein (PTHLH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [220]
Ceruletide DM2WE5K Caerulein stimulated gastric and pancreatic secretion 5A4Y Approved [398]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [399]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [78]
Testosterone DM7HUNW Hot flushes GA30 Approved [400]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [351]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [401]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By High affinity immunoglobulin gamma Fc receptor I (FCGR1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [402]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [224]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [194]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [337]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
Maleic Acid DM4L0R7 Discovery agent N.A. Investigative [403]
Rapamycin Immunosuppressant Drug DM678IB Discovery agent N.A. Investigative [402]
paraquat DMR8O3X Discovery agent N.A. Investigative [404]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eosinophil cationic protein (RNASE3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Zafirlukast DMHNQOG Asthma CA23 Approved [405]
Salmeterol DMIEU69 Allergic asthma CA23.0 Approved [406]
Budesonide DMJIBAW Allergic rhinitis CA08.0 Approved [405]
Diphenylpyraline DMW4X37 Allergic rhinitis CA08.0 Approved [407]
Arformoterol DMYM974 Chronic obstructive pulmonary disease CA22 Approved [408]
Beclomethasone dipropionate DM5NW1E Allergic rhinitis CA08.0 Phase 4 [409]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Interleukin-7 (IL7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [359]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [346]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [187]
Ethanol DMDRQZU Chronic pain MG30 Approved [346]
Oxymetholone DMFXUT8 Aplastic anemia 3A70 Approved [410]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [199]
Isoproterenol DMK7MEY Atrioventricular block Approved [411]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 4 (CCL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [141]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [109]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [364]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [365]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [351]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [365]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [187]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ribonuclease inhibitor (RNH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Selenium DM25CGV N. A. N. A. Approved [177]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [412]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [413]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [413]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [147]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Gefitinib DM15F0X Colon adenocarcinoma Approved [414]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [127]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [415]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [416]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [320]
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [417]
Quercetin DM3NC4M Obesity 5B81 Approved [240]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 5 (CCL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [418]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [225]
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [419]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [241]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [364]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [420]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metallothionein-1G (MT1G)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [253]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [421]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [422]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [303]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain E (HLA-E)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [286]
Clindamycin DM15HL8 Acne vulgaris ED80 Approved [286]
Selenium DM25CGV N. A. N. A. Approved [177]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [286]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [286]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [369]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [363]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [286]
Testosterone DM7HUNW Hot flushes GA30 Approved [136]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endoplasmin (HSP90B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [336]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [324]
Selenium DM25CGV N. A. N. A. Approved [177]
Quercetin DM3NC4M Obesity 5B81 Approved [423]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [369]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [424]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [425]
Testosterone enanthate DMB6871 N. A. N. A. Approved [198]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [426]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [427]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Selenium DM25CGV N. A. N. A. Approved [382]
Etretinate DM2CZFA Keratosis ED56 Approved [428]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [429]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [430]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [431]
Methotrexate DM2TEOL Anterior urethra cancer Approved [432]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [433]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Gefitinib DM15F0X Colon adenocarcinoma Approved [125]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [127]
Selenium DM25CGV N. A. N. A. Approved [434]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [435]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [436]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [437]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [438]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Leukemia inhibitory factor (LIF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [384]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [439]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [78]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [351]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon gamma receptor 1 (IFNGR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [235]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Methotrexate DM2TEOL Anterior urethra cancer Approved [384]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [78]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [440]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Clozapine DMFC71L Schizophrenia 6A20 Approved [354]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [441]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fos-related antigen 1 (FOSL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [330]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [76]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [335]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [442]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [255]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Membrane cofactor protein (CD46)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [235]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
ABIRATERONE DM8V75C Prostate cancer 2C82.0 Approved [443]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [443]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [249]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [444]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [245]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [155]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [445]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [247]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [446]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [275]
Quercetin DM3NC4M Obesity 5B81 Approved [447]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [278]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD44 antigen (CD44)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [235]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [448]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Selenium DM25CGV N. A. N. A. Approved [449]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [450]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [451]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [452]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [83]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADPH--cytochrome P450 reductase (POR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [453]
Selenium DM25CGV N. A. N. A. Approved [177]
Quercetin DM3NC4M Obesity 5B81 Approved [454]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [141]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [211]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [455]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [308]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [456]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [457]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [458]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [459]
Dacarbazine DMNPZL4 Adenocarcinoma 2D40 Approved [460]
Topotecan DMP6G8T Central nervous system neoplasm Approved [461]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Quercetin DM3NC4M Obesity 5B81 Approved [326]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [109]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [462]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [143]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor JunD (JUND)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [58]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [431]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [463]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [253]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [330]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [339]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [391]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor-binding protein 3 (IGFBP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [186]
Selenium DM25CGV N. A. N. A. Approved [464]
Methotrexate DM2TEOL Anterior urethra cancer Approved [96]
Quercetin DM3NC4M Obesity 5B81 Approved [465]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [466]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [467]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [468]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By T-complex protein 1 subunit alpha (TCP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [217]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [205]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [199]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [217]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [413]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphoglycerate mutase 1 (PGAM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [325]
Quercetin DM3NC4M Obesity 5B81 Approved [469]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [470]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [471]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [472]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [322]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [473]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [56]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [474]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [475]
Methotrexate DM2TEOL Anterior urethra cancer Approved [220]
Quercetin DM3NC4M Obesity 5B81 Approved [234]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [476]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [253]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [477]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [478]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione hydrolase 1 proenzyme (GGT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [199]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [479]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [480]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
Arsenic DMTL2Y1 N. A. N. A. Approved [481]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [56]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [482]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [391]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [48]
Gefitinib DM15F0X Colon adenocarcinoma Approved [483]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [484]
Methotrexate DM2TEOL Anterior urethra cancer Approved [485]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [486]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [487]
Quercetin DM3NC4M Obesity 5B81 Approved [234]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-X-C motif chemokine 2 (CXCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Selenium DM25CGV N. A. N. A. Approved [237]
Methotrexate DM2TEOL Anterior urethra cancer Approved [220]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [363]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [488]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [351]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-X-C motif chemokine 3 (CXCL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [148]
Methotrexate DM2TEOL Anterior urethra cancer Approved [220]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [38]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [350]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [489]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [302]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-A2 (CCNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [490]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [427]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [49]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [395]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [491]
Methotrexate DM2TEOL Anterior urethra cancer Approved [432]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [39]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [492]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [483]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [131]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [339]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [478]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [493]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [493]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [494]
Ethanol DMDRQZU Chronic pain MG30 Approved [346]
Menthol DMG2KW7 Back pain ME84.Z Approved [188]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2A7 (CYP2A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [81]
Testosterone DM7HUNW Hot flushes GA30 Approved [328]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [328]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [81]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [100]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [495]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [496]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Parathymosin (PTMS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Selenium DM25CGV N. A. N. A. Approved [177]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Ampicillin DMHWE7P Acute epiglottitis Approved [40]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [172]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [497]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione S-transferase Mu 3 (GSTM3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [141]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [109]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [254]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [172]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [498]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [182]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [499]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [499]
Ethacrynic acid DM60QMR Edema MG29 Approved [500]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [332]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [501]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [499]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Diamine acetyltransferase 1 (SAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Selenium DM25CGV N. A. N. A. Approved [177]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [502]
Methotrexate DM2TEOL Anterior urethra cancer Approved [432]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [503]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [503]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibroblast growth factor 7 (FGF7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [46]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [504]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [505]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [38]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [506]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [507]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catechol O-methyltransferase (COMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Epinephrine DM3KJBC Acute asthma CA23 Approved [508]
Dobutamine DMD1B8Z Heart failure BD10-BD13 Approved [508]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [508]
Modafinil DMYILBE Malignant glioma 2A00.0 Approved [509]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [508]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [510]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-10 (IL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [267]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [225]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [511]
Methotrexate DM2TEOL Anterior urethra cancer Approved [74]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [512]
Quercetin DM3NC4M Obesity 5B81 Approved [513]
Bisoprolol DM3UZ95 Hypertension BA00-BA04 Approved [514]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [359]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [242]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 1 (CCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [187]
Clozapine DMFC71L Schizophrenia 6A20 Approved [515]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [516]
Arsenic DMTL2Y1 N. A. N. A. Approved [517]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [195]
ACYLINE DM9GRTK Prostate cancer 2C82.0 Phase 2 [518]
ANW-32821 DMMJOZD N. A. N. A. Phase 2 [519]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [520]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [521]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Trans-acting T-cell-specific transcription factor GATA-3 (GATA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [278]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [522]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [523]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [524]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [350]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [525]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-32 (IL32)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [420]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Testosterone DM7HUNW Hot flushes GA30 Approved [328]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [328]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [199]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [526]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Immunoglobulin alpha Fc receptor (FCAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Folic Acid DMEMBJC Colorectal carcinoma Approved [527]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [182]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [528]
Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [48]
Gefitinib DM15F0X Colon adenocarcinoma Approved [483]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [529]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [431]
Methotrexate DM2TEOL Anterior urethra cancer Approved [530]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [219]
Quercetin DM3NC4M Obesity 5B81 Approved [531]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [532]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [533]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [254]
Haloperidol DM96SE0 Delirium Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [534]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [535]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [172]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [535]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [56]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [536]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [235]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [148]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [537]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [538]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [539]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [540]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Embryonic growth/differentiation factor 1 (GDF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [541]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [542]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [195]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [543]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [542]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [197]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-12 subunit beta (IL12B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [225]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [242]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [346]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [544]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [545]
Capsaicin DMGMF6V Back pain ME84.Z Approved [546]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [507]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [547]
Bryostatin-1 DM1JOXY Alzheimer disease 8A20 Phase 2 [548]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-1 (CASP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [235]
Gefitinib DM15F0X Colon adenocarcinoma Approved [236]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [549]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [149]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [319]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [308]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [550]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [551]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain F (HLA-F)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [286]
Selenium DM25CGV N. A. N. A. Approved [177]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [286]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [552]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [553]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [369]
Repaglinide DM5SXUV Diabetic complication 5A2Y Approved [286]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [421]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [191]
Saquinavir DMG814N Human immunodeficiency virus infection 1C62 Approved [286]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RNA-binding protein FUS (FUS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [177]
Methotrexate DM2TEOL Anterior urethra cancer Approved [220]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Testosterone DM7HUNW Hot flushes GA30 Approved [328]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [328]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [182]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bone morphogenetic protein receptor type-1A (BMPR1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [199]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [554]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Arsenic DMTL2Y1 N. A. N. A. Approved [165]
Ardeparin DMYRX8B Deep vein thrombosis BD71 Approved [555]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [556]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [557]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Activin receptor type-1B (ACVR1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [205]
Ethanol DMDRQZU Chronic pain MG30 Approved [558]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [559]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [560]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [561]
Arsenic DMTL2Y1 N. A. N. A. Approved [562]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [356]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [563]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [561]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon gamma receptor 2 (IFNGR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [235]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [335]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [564]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Arsenic DMTL2Y1 N. A. N. A. Approved [165]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [356]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [565]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [46]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [59]
Gefitinib DM15F0X Colon adenocarcinoma Approved [566]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [567]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Etretinate DM2CZFA Keratosis ED56 Approved [428]
Prednisone DM2HG4X Acute asthma CA23 Approved [568]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [429]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [569]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-F (CCNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Quercetin DM3NC4M Obesity 5B81 Approved [387]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [76]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [570]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [571]
Testosterone DM7HUNW Hot flushes GA30 Approved [328]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [328]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor B (CDKN2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [426]
Gefitinib DM15F0X Colon adenocarcinoma Approved [572]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Prednisone DM2HG4X Acute asthma CA23 Approved [568]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [573]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [574]
Testosterone DM7HUNW Hot flushes GA30 Approved [328]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [328]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor C (CDKN2C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [575]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [76]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [190]
Testosterone DM7HUNW Hot flushes GA30 Approved [328]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [328]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nicotinamide phosphoribosyltransferase (NAMPT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [362]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [369]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [576]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [255]
Testosterone DM7HUNW Hot flushes GA30 Approved [136]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [249]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [328]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [249]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Radiation-inducible immediate-early gene IEX-1 (IER3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Selenium DM25CGV N. A. N. A. Approved [237]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [525]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [369]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [245]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [150]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [577]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [578]
Quercetin DM3NC4M Obesity 5B81 Approved [579]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [580]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [370]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione synthetase (GSS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [529]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [581]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [494]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [582]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [583]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Arsenic DMTL2Y1 N. A. N. A. Approved [584]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylserine synthase 1 (PTDSS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [183]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [212]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [212]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Proteasome subunit beta type-3 (PSMB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [585]
Testosterone DM7HUNW Hot flushes GA30 Approved [136]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [95]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [413]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [177]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [322]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cysteine-rich protein 1 (CRIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [95]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [586]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [587]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [563]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Matrix metalloproteinase-14 (MMP14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [434]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [222]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Clozapine DMFC71L Schizophrenia 6A20 Approved [354]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [588]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [589]
Cysteamine DMSYFM8 Nephropathic cystinosis 5C60 Approved [590]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras association domain-containing protein 2 (RASSF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [369]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [351]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [103]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [172]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [591]
Indomethacin DMSC4A7 Bursitis Approved [592]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By T-complex protein 1 subunit delta (CCT4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
Aminoglutethimide DMWFHMZ Cushing disease 5A70 Approved [593]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [594]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [595]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [212]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [186]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C chemokine receptor type 5 (CCR5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [419]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [596]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [597]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [598]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [542]
I3C DMIGFOR Breast cancer 2C60-2C65 Phase 3 [599]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [600]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [520]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [542]
EUGENOL DM7US1H Discovery agent N.A. Patented [596]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Beta-defensin 1 (DEFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [81]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [350]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [199]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [95]
Arsenic DMTL2Y1 N. A. N. A. Approved [601]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [471]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD81 antigen (CD81)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [235]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [186]
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [369]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Ethanol DMDRQZU Chronic pain MG30 Approved [602]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [172]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [174]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [105]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [63]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [603]
Carfilzomib DM48K0X Multiple myeloma 2A83 Approved [604]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [605]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [606]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 10 kDa heat shock protein, mitochondrial (HSPE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [469]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [367]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [143]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [367]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Ethanol DMDRQZU Chronic pain MG30 Approved [607]
Folic Acid DMEMBJC Colorectal carcinoma Approved [608]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thymosin beta-4 (TMSB4X)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [211]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [301]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [302]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [609]
Indomethacin DMSC4A7 Bursitis Approved [610]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [611]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Small ribosomal subunit protein uS19 (RPS15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
PMID28870136-Compound-48 DMPIM9L N. A. N. A. Patented [60]
3R14S-OCHRATOXIN A DM2KEW6 Discovery agent N.A. Investigative [612]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [323]
AHPN DM8G6O4 Discovery agent N.A. Investigative [613]
chloropicrin DMSGBQA Discovery agent N.A. Investigative [614]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By T-complex protein 1 subunit beta (CCT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [615]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [351]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Menthol DMG2KW7 Back pain ME84.Z Approved [188]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [81]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [172]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [95]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [616]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Menthol DMG2KW7 Back pain ME84.Z Approved [188]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [102]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [617]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [618]
Arsenic DMTL2Y1 N. A. N. A. Approved [619]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [349]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein BTG2 (BTG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [569]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [620]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [621]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [76]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [571]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endonuclease III-like protein 1 (NTHL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [219]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [575]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [172]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [622]
Urethane DM7NSI0 N. A. N. A. Phase 4 [207]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [322]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 20 (CCL20)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [148]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [38]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [623]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 7 (CCL7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [164]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Isoproterenol DMK7MEY Atrioventricular block Approved [411]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [195]
Abexinostat DM91LGU Follicular lymphoma 2A80 Phase 3 [624]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [208]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [625]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metallothionein-1H (MT1H)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [131]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [253]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [421]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [187]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [303]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [302]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [306]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ADP-ribosylation factor 1 (ARF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [479]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [182]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [626]
Arsenic DMTL2Y1 N. A. N. A. Approved [165]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [455]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Selenium DM25CGV N. A. N. A. Approved [237]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [154]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [363]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [154]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [154]
Trihexyphenidyl DMB19L8 Dystonia 8A02 Approved [154]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [154]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor NF-kappa-B p100 subunit (NFKB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [235]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [48]
Methotrexate DM2TEOL Anterior urethra cancer Approved [384]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [131]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [335]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [627]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [628]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD83 antigen (CD83)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [629]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [630]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [631]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [186]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [632]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [632]
Quercetin DM3NC4M Obesity 5B81 Approved [633]
Fluoxetine DM3PD2C Bipolar depression Approved [632]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [131]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aminoacylase-1 (ACY1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [352]
Selenium DM25CGV N. A. N. A. Approved [177]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [369]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [615]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [401]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [81]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [634]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor alpha-induced protein 2 (TNFAIP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [177]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [38]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [635]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Urokinase plasminogen activator surface receptor (PLAUR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [448]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [636]
Quercetin DM3NC4M Obesity 5B81 Approved [221]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [637]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [339]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [638]
Testosterone DM7HUNW Hot flushes GA30 Approved [328]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [639]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [328]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sialomucin core protein 24 (CD164)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [363]
Testosterone DM7HUNW Hot flushes GA30 Approved [136]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [494]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [355]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [172]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [181]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [640]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 2 (DUSP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [420]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [641]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [187]
Epanova DMHEAGL Hypertriglyceridemia 5C80.1 Approved [642]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [643]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [644]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Regulator of G-protein signaling 1 (RGS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [350]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [187]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [645]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [646]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [600]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [647]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [253]
Quinolones DM5GVHU Bacterial infection 1A00-1C4Z Approved [648]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [649]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [44]
Testosterone DM7HUNW Hot flushes GA30 Approved [136]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [249]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TNF receptor-associated factor 1 (TRAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [650]
Methotrexate DM2TEOL Anterior urethra cancer Approved [432]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [420]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [350]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [187]
Folic Acid DMEMBJC Colorectal carcinoma Approved [171]
Menthol DMG2KW7 Back pain ME84.Z Approved [188]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [651]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [536]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [186]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [652]
Methotrexate DM2TEOL Anterior urethra cancer Approved [384]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [131]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [525]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [653]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [501]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [654]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [652]
Methotrexate DM2TEOL Anterior urethra cancer Approved [655]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [656]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [657]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [109]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [367]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [253]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-I (CCNI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [95]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [194]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [257]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [563]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [197]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [625]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [658]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit A (EIF3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [423]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [187]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [561]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [659]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [174]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic initiation factor 4A-II (EIF4A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [187]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [660]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [181]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [561]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TNFAIP3-interacting protein 1 (TNIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [661]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [205]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [199]
Arsenic DMTL2Y1 N. A. N. A. Approved [662]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [663]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [563]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Inorganic pyrophosphatase (PPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Haloperidol DM96SE0 Delirium Approved [66]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Benzatropine DMF7EXL Parkinsonian disorder Approved [66]
Clozapine DMFC71L Schizophrenia 6A20 Approved [66]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [302]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [181]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Reticulocalbin-1 (RCN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Haloperidol DM96SE0 Delirium Approved [66]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [301]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [182]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [95]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [507]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [349]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NT-3 growth factor receptor (NTRK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [186]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [664]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [205]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [559]
Arsenic DMTL2Y1 N. A. N. A. Approved [165]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [349]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [665]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [496]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [666]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [667]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [668]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Methotrexate DM2TEOL Anterior urethra cancer Approved [74]
Quercetin DM3NC4M Obesity 5B81 Approved [669]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [76]
Ethacrynic acid DM60QMR Edema MG29 Approved [670]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [671]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [672]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-related protein A1 (BCL2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [673]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [363]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [216]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [187]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [674]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [675]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [38]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [644]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Anti-Muellerian hormone type-2 receptor (AMHR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [440]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [660]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [526]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [542]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [542]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [197]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [676]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 5 (DUSP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [677]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [678]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Testosterone DM7HUNW Hot flushes GA30 Approved [328]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [249]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Programmed cell death protein 4 (PDCD4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [499]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [679]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [499]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [253]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [680]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [499]
Testosterone DM7HUNW Hot flushes GA30 Approved [136]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [131]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [81]
Ampicillin DMHWE7P Acute epiglottitis Approved [40]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [356]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Type-1 angiotensin II receptor-associated protein (AGTRAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [220]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Bortezomib DMNO38U Leukemia Approved [200]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [356]
Urethane DM7NSI0 N. A. N. A. Phase 4 [207]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [681]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Scavenger receptor class B member 1 (SCARB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [682]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [683]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [684]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [131]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [685]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [686]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [687]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [628]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TRAF family member-associated NF-kappa-B activator (TANK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Testosterone DM7HUNW Hot flushes GA30 Approved [136]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [393]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [187]
Menthol DMG2KW7 Back pain ME84.Z Approved [188]
Bortezomib DMNO38U Leukemia Approved [200]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [561]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [688]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon regulatory factor 7 (IRF7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [689]
Testosterone DM7HUNW Hot flushes GA30 Approved [328]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [328]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [244]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [81]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [38]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ribonuclease K6 (RNASE6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [431]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [440]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [182]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [690]
Drug(s) Affected By Fermitin family homolog 2 (FERMT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [243]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Testosterone enanthate DMB6871 N. A. N. A. Approved [198]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Folic Acid DMEMBJC Colorectal carcinoma Approved [527]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [302]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 19 (CCL19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [431]
Arsenic DMTL2Y1 N. A. N. A. Approved [517]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [691]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [349]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [195]
EUGENOL DM7US1H Discovery agent N.A. Patented [596]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [187]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Microsomal glutathione S-transferase 2 (MGST2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [692]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [330]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [172]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [526]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BAG family molecular chaperone regulator 1 (BAG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [177]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [693]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [694]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [205]
Menthol DMG2KW7 Back pain ME84.Z Approved [188]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [675]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [559]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [695]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cbp/p300-interacting transactivator 1 (CITED1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [494]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [696]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [185]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [349]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [556]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TNF receptor-associated factor 4 (TRAF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [177]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [693]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [44]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Ethanol DMDRQZU Chronic pain MG30 Approved [602]
Folic Acid DMEMBJC Colorectal carcinoma Approved [171]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proteasome activator complex subunit 2 (PSME2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [352]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [287]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [349]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [337]
MG-132 DMKA2YS N. A. N. A. Preclinical [697]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Small ribosomal subunit protein bS1m (MRPS28)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [668]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [205]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [480]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [622]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [114]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [698]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [197]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [699]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [700]
Milchsaure DM462BT Pruritus EC90 Investigative [167]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [701]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [701]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [701]
Capsaicin DMGMF6V Back pain ME84.Z Approved [702]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [703]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [704]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [705]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [706]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [707]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [56]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-14 (CASP14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [350]
Menthol DMG2KW7 Back pain ME84.Z Approved [188]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [675]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [194]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [708]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [709]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
Milchsaure DM462BT Pruritus EC90 Investigative [167]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [384]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [710]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [711]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [712]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [713]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [714]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [456]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon-related developmental regulator 1 (IFRD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [324]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [525]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [369]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [332]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [494]
Ampicillin DMHWE7P Acute epiglottitis Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Suppressor of cytokine signaling 3 (SOCS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Methotrexate DM2TEOL Anterior urethra cancer Approved [220]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [229]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [278]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Fedratinib DM4ZBK6 Myelofibrosis 2A20.2 Approved [715]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Pyrimethamine DM5X7VY Malaria 1F40-1F45 Approved [715]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [278]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Telomerase reverse transcriptase (TERT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [716]
Gefitinib DM15F0X Colon adenocarcinoma Approved [717]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [339]
Selenium DM25CGV N. A. N. A. Approved [718]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [719]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [720]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [721]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [722]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [477]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor protein p73 (TP73)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [723]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [186]
Etretinate DM2CZFA Keratosis ED56 Approved [428]
Quercetin DM3NC4M Obesity 5B81 Approved [531]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [653]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [351]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [641]
Menthol DMG2KW7 Back pain ME84.Z Approved [188]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [724]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [428]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Toll-like receptor 3 (TLR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [384]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [82]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Testosterone DM7HUNW Hot flushes GA30 Approved [328]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [725]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Testosterone enanthate DMB6871 N. A. N. A. Approved [198]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ethanol DMDRQZU Chronic pain MG30 Approved [726]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibroblast growth factor 10 (FGF10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [190]
Arsenic DMTL2Y1 N. A. N. A. Approved [165]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [496]
Chondroitin sulfate DM0N19Y N. A. N. A. Phase 4 [727]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [197]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 14 (TNFSF14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Methotrexate DM2TEOL Anterior urethra cancer Approved [728]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [363]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Menthol DMG2KW7 Back pain ME84.Z Approved [188]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [349]
Urethane DM7NSI0 N. A. N. A. Phase 4 [207]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [337]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein sprouty homolog 2 (SPRY2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [186]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [103]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [172]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein sprouty homolog 1 (SPRY1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [249]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [249]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [249]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pituitary homeobox 3 (PITX3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [729]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [496]
Urethane DM7NSI0 N. A. N. A. Phase 4 [207]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [730]
Drug(s) Affected By Probable G-protein coupled receptor 32 (GPR32)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [349]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [258]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [186]
KOJIC ACID DMP84CS Discovery agent N.A. Investigative [731]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Dickkopf-related protein 1 (DKK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Quercetin DM3NC4M Obesity 5B81 Approved [732]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [332]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [98]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [78]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [733]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [450]
Quercetin DM3NC4M Obesity 5B81 Approved [734]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [82]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [735]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [736]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [737]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [738]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Angiotensinogen (AGT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [739]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [740]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [741]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [742]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [743]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [744]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [745]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [746]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pentoxifylline DMU3DNC Alcoholic hepatitis DB94.1 Approved [56]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [315]
Verapamil DMA7PEW Angina pectoris BA40 Approved [747]
Selenium DM25CGV N. A. N. A. Approved [434]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [747]
Quercetin DM3NC4M Obesity 5B81 Approved [748]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [131]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [222]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [749]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [750]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [56]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [474]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [751]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [752]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [415]
Prednisone DM2HG4X Acute asthma CA23 Approved [753]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [754]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [755]
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(II) chain (COL2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [756]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [588]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [643]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [757]
Indomethacin DMSC4A7 Bursitis Approved [592]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [592]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibronectin (FN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [758]
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Aripiprazole DM3NUMH Bipolar I disorder Approved [759]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [760]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [761]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [369]
Ethacrynic acid DM60QMR Edema MG29 Approved [762]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [763]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [44]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Estrogen receptor (ESR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [764]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [765]
Gefitinib DM15F0X Colon adenocarcinoma Approved [766]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [767]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [768]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [769]
Quercetin DM3NC4M Obesity 5B81 Approved [770]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [771]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [767]
Estrone DM5T6US Acne vulgaris ED80 Approved [772]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Vitamin K-dependent protein C (PROC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Desogestrel DM27U4Y Contraception QA21 Approved [773]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Testosterone DM7HUNW Hot flushes GA30 Approved [136]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Testosterone enanthate DMB6871 N. A. N. A. Approved [774]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Clozapine DMFC71L Schizophrenia 6A20 Approved [775]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [81]
Clomipramine DMINRKW Depression 6A70-6A7Z Approved [776]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock protein beta-1 (HSPB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [668]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [352]
Selenium DM25CGV N. A. N. A. Approved [177]
Methotrexate DM2TEOL Anterior urethra cancer Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [253]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [777]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [78]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [393]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [563]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein S100-A8 (S100A8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [778]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [39]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [778]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [311]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [363]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [778]
Dicloxacillin DM8EU0Z Bacterial infection 1A00-1C4Z Approved [778]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endothelin-1 (EDN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [779]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [351]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [780]
Methotrexate DM2TEOL Anterior urethra cancer Approved [384]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [781]
Quercetin DM3NC4M Obesity 5B81 Approved [782]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [783]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [784]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [785]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glia-derived nexin (SERPINE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Methotrexate DM2TEOL Anterior urethra cancer Approved [384]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Macrophage colony-stimulating factor 1 receptor (CSF1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [369]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [786]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [440]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [787]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [172]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [788]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cathepsin D (CTSD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [789]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [790]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [791]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [792]
Testosterone DM7HUNW Hot flushes GA30 Approved [136]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thrombospondin-1 (THBS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [633]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [38]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [311]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [211]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 16 (NGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [793]
Methotrexate DM2TEOL Anterior urethra cancer Approved [220]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [794]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [795]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [795]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [350]
Oxaprozin DM9UB0P Osteoarthritis FA00-FA05 Approved [796]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Zinc finger protein GLI1 (GLI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [711]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [797]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [351]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [798]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [191]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Arsenic DMTL2Y1 N. A. N. A. Approved [799]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [800]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [801]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 72 kDa type IV collagenase (MMP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [802]
Selenium DM25CGV N. A. N. A. Approved [434]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [803]
Quercetin DM3NC4M Obesity 5B81 Approved [804]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [805]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [806]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [369]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [222]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [749]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [807]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [808]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [809]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [810]
Fructose DM43AN2 Vomiting MD90 Approved [811]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [635]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [812]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [199]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [813]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Granulocyte colony-stimulating factor (CSF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [148]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [657]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [523]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [270]
Ethanol DMDRQZU Chronic pain MG30 Approved [346]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [305]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [38]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [814]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calmodulin-1 (CALM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Selenium DM25CGV N. A. N. A. Approved [177]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [431]
Methotrexate DM2TEOL Anterior urethra cancer Approved [384]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [431]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Clusterin (CLU)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [747]
Selenium DM25CGV N. A. N. A. Approved [177]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [747]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [278]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [815]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [254]
Testosterone DM7HUNW Hot flushes GA30 Approved [136]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [747]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neurofilament heavy polypeptide (NEFH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [46]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [816]
Scopolamine DMOM8AL Addictive disorder 6C50-6C5Z Approved [817]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [818]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [182]
Arsenic DMTL2Y1 N. A. N. A. Approved [819]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fos-related antigen 2 (FOSL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [255]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [249]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [249]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amphiregulin (AREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [820]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [220]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [821]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [822]
Estrone DM5T6US Acne vulgaris ED80 Approved [448]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [76]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [78]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [823]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mucin-1 (MUC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [824]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [825]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [369]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [826]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [350]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [826]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Folic Acid DMEMBJC Colorectal carcinoma Approved [827]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [646]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [828]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metalloproteinase inhibitor 2 (TIMP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [829]
Selenium DM25CGV N. A. N. A. Approved [434]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [761]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [222]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [211]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Tetracaine DM9J6C2 Spinal anesthesia MB40.3 Approved [830]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [351]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Early growth response protein 1 (EGR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [220]
Quercetin DM3NC4M Obesity 5B81 Approved [531]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [141]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [109]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [831]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [219]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [143]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-1 receptor antagonist protein (IL1RN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [278]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [82]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [363]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [269]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [832]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [431]
Methotrexate DM2TEOL Anterior urethra cancer Approved [833]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [39]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [251]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [253]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Follistatin (FST)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [148]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [677]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Testosterone DM7HUNW Hot flushes GA30 Approved [136]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [834]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [172]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-11 (IL11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Methotrexate DM2TEOL Anterior urethra cancer Approved [432]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [835]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [78]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ethanol DMDRQZU Chronic pain MG30 Approved [836]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [837]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [838]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [839]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [840]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [841]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [842]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [843]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [844]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [845]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [846]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 5'-nucleotidase (NT5E)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [235]
Quercetin DM3NC4M Obesity 5B81 Approved [847]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [82]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [254]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [187]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [81]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [172]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-(1,3)-fucosyltransferase 4 (FUT4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [343]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ethanol DMDRQZU Chronic pain MG30 Approved [848]
Arsenic DMTL2Y1 N. A. N. A. Approved [165]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [183]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [849]
Urethane DM7NSI0 N. A. N. A. Phase 4 [207]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibroblast growth factor receptor 3 (FGFR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [82]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [369]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [850]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [850]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [78]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [851]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [852]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [494]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [160]
Quercetin DM3NC4M Obesity 5B81 Approved [853]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [141]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [109]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Bupivacaine DM4PRFC Anaesthesia 9A78.6 Approved [854]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [311]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tenascin (TNC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diazepam DM08E9O Alcohol withdrawal Approved [855]
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [278]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [278]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [856]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [857]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [494]
Capsaicin DMGMF6V Back pain ME84.Z Approved [858]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [199]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proteinase-activated receptor 1 (F2R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Selenium DM25CGV N. A. N. A. Approved [177]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [835]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [859]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [493]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [493]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dipeptidyl peptidase 4 (DPP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Saxagliptin DMGXENV Type-2 diabetes 5A11 Approved [860]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [861]
Testosterone DM7HUNW Hot flushes GA30 Approved [136]
Alogliptin DM8WI3R Type-2 diabetes 5A11 Approved [862]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [350]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [556]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [103]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [863]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [864]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [865]
Paclitaxel DMLB81S Breast carcinoma Approved [866]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [867]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [868]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [56]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [235]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [104]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [869]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [786]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [254]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [786]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Menthol DMG2KW7 Back pain ME84.Z Approved [188]
Quinidine DMLPICK N. A. N. A. Approved [786]
Arsenic DMTL2Y1 N. A. N. A. Approved [517]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [174]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [101]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [870]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium/calcium exchanger 1 (SLC8A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [871]
Arsenic DMTL2Y1 N. A. N. A. Approved [165]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [872]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [183]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [444]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [496]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [873]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [874]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [197]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [875]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [876]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [877]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [837]
Capsaicin DMGMF6V Back pain ME84.Z Approved [702]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [878]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [704]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [878]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [876]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [56]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Merlin (NF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Selenium DM25CGV N. A. N. A. Approved [177]
Methotrexate DM2TEOL Anterior urethra cancer Approved [220]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [879]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [880]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [559]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [95]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pro-adrenomedullin (ADM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [46]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [677]
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [881]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [351]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [482]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TGF-beta receptor type-2 (TGFBR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diazepam DM08E9O Alcohol withdrawal Approved [855]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Methotrexate DM2TEOL Anterior urethra cancer Approved [882]
Quercetin DM3NC4M Obesity 5B81 Approved [387]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [369]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [883]
Testosterone DM7HUNW Hot flushes GA30 Approved [328]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [328]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Squalene synthase (FDFT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [884]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Fluoxetine DM3PD2C Bipolar depression Approved [885]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [369]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [886]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [628]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(XVIII) chain (COL18A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [186]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Selenium DM25CGV N. A. N. A. Approved [177]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Capsaicin DMGMF6V Back pain ME84.Z Approved [887]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [199]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 8 (MAP3K8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Selenium DM25CGV N. A. N. A. Approved [177]
Methotrexate DM2TEOL Anterior urethra cancer Approved [220]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [131]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagenase 3 (MMP13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [888]
Clindamycin DM15HL8 Acne vulgaris ED80 Approved [889]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [888]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [39]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [890]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [891]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [190]
Doxycycline DM7ICNU Acne vulgaris ED80 Approved [889]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [639]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [856]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [892]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [893]
Propranolol DM79NTF Angina pectoris BA40 Approved [894]
Testosterone DM7HUNW Hot flushes GA30 Approved [136]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [102]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [895]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [172]
Mebendazole DMO14SG Ascariasis 1F62 Approved [896]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By LIM/homeobox protein Lhx1 (LHX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Indomethacin DMSC4A7 Bursitis Approved [592]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [592]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By CCAAT/enhancer-binding protein alpha (CEBPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [654]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [897]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [898]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [899]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [900]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [78]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [900]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [628]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [901]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [105]
Selenium DM25CGV N. A. N. A. Approved [177]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [902]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [903]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [141]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [575]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [466]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eotaxin (CCL11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prednisone DM2HG4X Acute asthma CA23 Approved [904]
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [905]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [364]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [78]
Ethanol DMDRQZU Chronic pain MG30 Approved [346]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [906]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [349]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [907]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By High mobility group protein HMGI-C (HMGA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [46]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [187]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [103]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [644]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [695]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (PLCB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Testosterone DM7HUNW Hot flushes GA30 Approved [136]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [182]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [183]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [908]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [908]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [690]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [197]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Runt-related transcription factor 1 (RUNX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [186]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Testosterone DM7HUNW Hot flushes GA30 Approved [328]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [249]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [249]
Cotinine DMCEZ1B Insecticide N.A. Approved [909]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Angiopoietin-1 receptor (TEK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [493]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [493]
Propranolol DM79NTF Angina pectoris BA40 Approved [910]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Capsaicin DMGMF6V Back pain ME84.Z Approved [887]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [588]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [349]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [911]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [912]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [668]
Methotrexate DM2TEOL Anterior urethra cancer Approved [220]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Testosterone enanthate DMB6871 N. A. N. A. Approved [198]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Ethanol DMDRQZU Chronic pain MG30 Approved [602]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [172]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Forkhead box protein M1 (FOXM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [913]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [432]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [190]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [255]
Testosterone DM7HUNW Hot flushes GA30 Approved [328]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [914]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-24 (IL24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [154]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [148]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [154]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [154]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [915]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [154]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [311]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Semaphorin-3B (SEMA3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [186]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Selenium DM25CGV N. A. N. A. Approved [177]
Methotrexate DM2TEOL Anterior urethra cancer Approved [384]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [916]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [856]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [917]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [336]
Selenium DM25CGV N. A. N. A. Approved [177]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Testosterone DM7HUNW Hot flushes GA30 Approved [136]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [456]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [917]
Arsenic DMTL2Y1 N. A. N. A. Approved [165]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [587]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Growth factor receptor-bound protein 14 (GRB14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [401]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [199]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [918]
Arsenic DMTL2Y1 N. A. N. A. Approved [165]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [356]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [820]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [634]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Angiopoietin-1 (ANGPT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [919]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Selenium DM25CGV N. A. N. A. Approved [177]
Methotrexate DM2TEOL Anterior urethra cancer Approved [920]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [278]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [308]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 6 (DUSP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [131]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [831]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [921]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sprouty-related, EVH1 domain-containing protein 1 (SPRED1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [187]
Folic Acid DMEMBJC Colorectal carcinoma Approved [527]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [644]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [194]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [183]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein ESX1 (ESX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [563]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [922]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
Drug(s) Affected By Pleckstrin homology-like domain family A member 1 (PHLDA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [351]
Testosterone enanthate DMB6871 N. A. N. A. Approved [198]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein phosphatase Slingshot homolog 1 (SSH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Arsenic DMTL2Y1 N. A. N. A. Approved [923]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [194]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [205]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [557]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [212]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [186]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein NDRG1 (NDRG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [127]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [924]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [925]
Quercetin DM3NC4M Obesity 5B81 Approved [633]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [191]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [660]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [172]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein kinase C-binding protein NELL1 (NELL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [560]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [926]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [349]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [496]
Chlorothiazide DMLHESP Chronic heart failure BD1Z Approved [927]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [928]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (INPP5D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [526]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [174]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [471]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [205]
Urethane DM7NSI0 N. A. N. A. Phase 4 [207]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [101]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By GRIP and coiled-coil domain-containing protein 1 (GCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [205]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [695]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [917]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [194]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
Urethane DM7NSI0 N. A. N. A. Phase 4 [207]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [563]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [197]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [190]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [103]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [172]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mucin-4 (MUC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [177]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [929]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [930]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [101]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [931]
Forskolin DM6ITNG Solid tumour/cancer 2A00-2F9Z Investigative [932]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [930]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Apolipoprotein L2 (APOL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Leflunomide DMR8ONJ Arthritis FA20 Approved [99]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [180]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [917]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [356]
Urethane DM7NSI0 N. A. N. A. Phase 4 [207]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [700]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [933]
Nickel chloride DMI12Y8 Discovery agent N.A. Investigative [934]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Testosterone DM7HUNW Hot flushes GA30 Approved [136]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [351]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [199]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [172]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [479]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [526]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By SH2 domain-containing protein 2A (SH2D2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [78]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [192]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [183]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [709]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [205]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [690]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [935]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Interleukin-23 subunit alpha (IL23A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [229]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [38]
Misoprostol DMHVJFK Medical abortion JA00.1Z Approved [936]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [200]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [38]
Bortezomib DMNO38U Leukemia Approved [937]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [206]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [38]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [38]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Appetite-regulating hormone (GHRL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Arsenic DMTL2Y1 N. A. N. A. Approved [165]
Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [875]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [938]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [878]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [877]
Capsaicin DMGMF6V Back pain ME84.Z Approved [702]
Zafirlukast DMHNQOG Asthma CA23 Approved [939]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [878]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [940]
Fluconazole DMOWZ6B Cryptococcal meningitis Approved [877]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [878]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [941]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [942]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [941]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [942]
Sulfinpyrazone DMEV954 Gout FA25 Approved [943]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [941]
Zafirlukast DMHNQOG Asthma CA23 Approved [941]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [941]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [944]
Dabrafenib DMX6OE3 Melanoma 2C30 Approved [945]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-1 receptor-like 1 (IL1RL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [856]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [643]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [946]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [947]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [471]
Seocalcitol DMKL9QO Rickets 5B57 Phase 3 [856]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [948]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [875]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [949]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [877]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [878]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [878]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [812]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [950]
Capsaicin DMGMF6V Back pain ME84.Z Approved [951]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [952]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [948]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [875]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [950]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [950]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [953]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [954]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [955]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [179]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [956]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [957]
Paliperidone DM7NPJS Psychotic disorder 6A20-6A25 Approved [958]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [959]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [960]
Oxatomide DM1F42Z Hay fever CA08.00 Approved [961]
Cinacalcet DMCX0K3 Hyperparathyroidism 5A51 Approved [962]
Capsaicin DMGMF6V Back pain ME84.Z Approved [702]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [878]
Quinidine DMLPICK N. A. N. A. Approved [963]
Buprenorphine DMPRI8G Opioid dependence 6C43.2Z Approved [964]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glutamate receptor ionotropic NMDA 1 (NMDAR1) TTLD29N NMDZ1_HUMAN Inhibitor [2]
Glutamate receptor ionotropic NMDA 2A (NMDAR2A) TTKJEMQ NMDE1_HUMAN Inhibitor [2]
Glutamate receptor ionotropic NMDA 2B (NMDAR2B) TTN9D8E NMDE2_HUMAN Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (PLCB2) OTPAHDGO PLCB2_HUMAN Gene/Protein Processing [4]
10 kDa heat shock protein, mitochondrial (HSPE1) OT7JSZLB CH10_HUMAN Gene/Protein Processing [5]
5'-nucleotidase (NT5E) OT7J5LT6 5NTD_HUMAN Gene/Protein Processing [4]
60 kDa heat shock protein, mitochondrial (HSPD1) OTTO1Y11 CH60_HUMAN Gene/Protein Processing [5]
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Protein Interaction/Cellular Processes [6]
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) OTJC60Q7 THIL_HUMAN Gene/Protein Processing [5]
Activin receptor type-1B (ACVR1B) OT778HIQ ACV1B_HUMAN Gene/Protein Processing [5]
ADAM DEC1 (ADAMDEC1) OTMT7ZMG ADEC1_HUMAN Gene/Protein Processing [5]
ADP-ribosylation factor 1 (ARF1) OT5C4C3L ARF1_HUMAN Gene/Protein Processing [5]
Aldehyde dehydrogenase, mitochondrial (ALDH2) OTKJ9I3N ALDH2_HUMAN Gene/Protein Processing [5]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4282).
2 Synthesis and biological activity of conformationally restricted analogs of milnacipran: (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopro... J Med Chem. 1996 Nov 22;39(24):4844-52.
3 Drug transporters of platinum-based anticancer agents and their clinical significance. Drug Resist Updat. 2011 Feb;14(1):22-34.
4 Microarray Analysis of Gene Expression Alteration in Human Middle Ear Epithelial Cells Induced by Asian Sand Dust. Clin Exp Otorhinolaryngol. 2015 Dec;8(4):345-53. doi: 10.3342/ceo.2015.8.4.345. Epub 2015 Nov 10.
5 Differential response of Mono Mac 6, BEAS-2B, and Jurkat cells to indoor dust. Environ Health Perspect. 2007 Sep;115(9):1325-32.
6 Effects of Agricultural Organic Dusts on Human Lung-Resident Mesenchymal Stem (Stromal) Cell Function. Toxicol Sci. 2018 Apr 1;162(2):635-644. doi: 10.1093/toxsci/kfx286.
7 Glycine transport inhibitors for the treatment of schizophrenia: Symptom and disease modification. Curr Opin Drug Discov Devel. 2009 Jul;12(4):468-78.
8 Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,... J Med Chem. 2001 Sep 13;44(19):3157-65.
9 4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with... Bioorg Med Chem Lett. 2000 May 15;10(10):1133-7.
10 Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. J Med Chem. 2010 May 13;53(9):3611-7.
11 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456).
12 Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993).
13 Synthesis and evaluation of 6,11-ethanohexahydrobenzo[b]quinolizidines: a new class of noncompetitive N-methyl-D-aspartate antagonists. J Med Chem. 1995 Jun 23;38(13):2483-9.
14 Indeno[1,2-b]pyrazin-2,3-diones: a new class of antagonists at the glycine site of the NMDA receptor with potent in vivo activity. J Med Chem. 2000 Jun 15;43(12):2371-81.
15 Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor. J Med Chem. 2006 Feb 9;49(3):864-71.
16 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
17 Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.
18 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist. J Med Chem. 1999 Jul 29;42(15):2993-3000.
19 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 455).
20 NMDA receptor stimulation induces reversible fission of the neuronal endoplasmic reticulum. PLoS One. 2009;4(4):e5250.
21 NMDA receptors as targets for drug action in neuropathic pain. Eur J Pharmacol. 2001 Oct 19;429(1-3):71-8.
22 Inhibition of in vivo [(3)H]MK-801 binding by NMDA receptor open channel blockers and GluN2B antagonists in rats and mice. Eur J Pharmacol. 2015 Nov 5;766:1-8.
23 Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.
24 Clinical pipeline report, company report or official report of Cadent Therapeutics.
25 Neu2000, an NR2B-selective, moderate NMDA receptor antagonist and potent spin trapping molecule for stroke. Drug News Perspect. 2010 Nov;23(9):549-56.
26 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
27 Are organic cation transporters capable of transporting prostaglandins? Naunyn Schmiedebergs Arch Pharmacol. 2005 Aug;372(2):125-30.
28 Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family). J Pharmacol Exp Ther. 2006 Nov;319(2):879-86.
29 Pharmacologic markers and predictors of responses to imatinib therapy in patients with chronic myeloid leukemia. Leuk Lymphoma. 2008 Apr;49(4):639-42.
30 Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Res. 2006 Sep 1;66(17):8847-57.
31 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
32 Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett. 2006 Mar 8;234(1):4-33.
33 Upregulation of histone acetylation reverses organic anion transporter 2 repression and enhances 5-fluorouracil sensitivity in hepatocellular carcinoma
34 Comparison of type I and type II organic cation transport by organic cation transporters and organic anion-transporting polypeptides. J Pharmacol Exp Ther. 2001 Jul;298(1):110-5.
35 Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences. Drug Metab Pharmacokinet. 2008;23(4):243-53.
36 Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants. Biol Pharm Bull. 2017;40(8):1139-1145.
37 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
38 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
39 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
40 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
41 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
42 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
43 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
44 Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3767-77.
45 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
46 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
47 Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro. Toxicol Sci. 2003 Aug;74(2):260-70. doi: 10.1093/toxsci/kfg113. Epub 2003 May 2.
48 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
49 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
50 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
51 Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937. Arthritis Res Ther. 2014 Jan 20;16(1):R17. doi: 10.1186/ar4444.
52 Simvastatin inhibits NOR-1 expression induced by hyperlipemia by interfering with CREB activation. Cardiovasc Res. 2005 Aug 1;67(2):333-41. doi: 10.1016/j.cardiores.2005.03.016. Epub 2005 Apr 21.
53 The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells. J Biol Chem. 2004 Jun 25;279(26):27008-16. doi: 10.1074/jbc.M403588200. Epub 2004 Apr 16.
54 High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells. Blood. 1993 Nov 15;82(10):3133-40.
55 Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples. Data Brief. 2016 Mar 26;7:1052-1057. doi: 10.1016/j.dib.2016.03.069. eCollection 2016 Jun.
56 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
57 Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
58 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
59 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
60 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
61 Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem. 2002 Nov 15;277(46):43648-58. doi: 10.1074/jbc.M203214200. Epub 2002 Sep 6.
62 [Regulation mechanism of autophagy-related protein LC3 by c-Jun in methotrexate resistant human choriocarcinoma JEG-3 cells]. Zhonghua Fu Chan Ke Za Zhi. 2014 Jul;49(7):531-5.
63 Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
64 Insulin regulation of hexose transport in mouse 3T3-L1 cells expressing the human HepG2 glucose transporter. J Biol Chem. 1990 Nov 25;265(33):20106-16.
65 Effects of troglitazone on cellular differentiation, insulin signaling, and glucose metabolism in cultured human skeletal muscle cells. Biochem Biophys Res Commun. 2001 Jan 26;280(3):664-74. doi: 10.1006/bbrc.2000.4216.
66 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
67 Disturbance of cellular glucose transport by two prevalently used fluoroquinolone antibiotics ciprofloxacin and levofloxacin involves glucose transporter type 1. Toxicol Lett. 2009 Jan 30;184(2):81-4. doi: 10.1016/j.toxlet.2008.10.017. Epub 2008 Oct 28.
68 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
69 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
70 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
71 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
72 Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
73 Complex genetic response of human cells to sublethal levels of pure nitric oxide. Cancer Res. 1998 Aug 1;58(15):3435-40.
74 Inflammation in methotrexate-induced pulmonary toxicity occurs via the p38 MAPK pathway. Toxicology. 2009 Feb 27;256(3):183-90. doi: 10.1016/j.tox.2008.11.016. Epub 2008 Nov 28.
75 Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
76 Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
77 Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells. Lipids Health Dis. 2010 Jun 2;9:56. doi: 10.1186/1476-511X-9-56.
78 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
79 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
80 Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
81 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
82 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
83 The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells. Chem Biol Interact. 2019 Apr 1;302:28-35. doi: 10.1016/j.cbi.2019.01.033. Epub 2019 Jan 28.
84 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
85 Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
86 COX-2 and PPAR-gama confer cannabidiol-induced apoptosis of human lung cancer cells. Mol Cancer Ther. 2013 Jan;12(1):69-82.
87 Protective effects of myricitrin against osteoporosis via reducing reactive oxygen species and bone-resorbing cytokines. Toxicol Appl Pharmacol. 2014 Nov 1;280(3):550-60.
88 The effect of quercetin and kaempferol aglycones and glucuronides on peroxisome proliferator-activated receptor-gamma (PPAR-). Food Funct. 2015 Apr;6(4):1098-107. doi: 10.1039/c5fo00076a.
89 Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3951-6. doi: 10.1073/pnas.96.7.3951.
90 Glucosamine sulfate reduces prostaglandin E(2) production in osteoarthritic chondrocytes through inhibition of microsomal PGE synthase-1. J Rheumatol. 2012 Mar;39(3):635-44. doi: 10.3899/jrheum.110621. Epub 2011 Nov 15.
91 Isoniazid suppresses antioxidant response element activities and impairs adipogenesis in mouse and human preadipocytes. Toxicol Appl Pharmacol. 2013 Dec 15;273(3):435-41. doi: 10.1016/j.taap.2013.10.005. Epub 2013 Oct 12.
92 Regulatory role of KEAP1 and NRF2 in PPAR expression and chemoresistance in human non-small-cell lung carcinoma cells. Free Radic Biol Med. 2012 Aug 15;53(4):758-68. doi: 10.1016/j.freeradbiomed.2012.05.041. Epub 2012 Jun 7.
93 Aspirin inhibits MMP-9 mRNA expression and release via the PPARalpha/gamma and COX-2/mPGES-1-mediated pathways in macrophages derived from THP-1 cells. Biomed Pharmacother. 2010 Feb;64(2):118-23. doi: 10.1016/j.biopha.2009.04.033. Epub 2009 Oct 17.
94 Mitochondrial proliferation, DNA depletion and adipocyte differentiation in subcutaneous adipose tissue of HIV-positive HAART recipients. Antivir Ther. 2003 Aug;8(4):323-31.
95 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
96 Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
97 Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
98 How benzene and its metabolites affect human marrow derived mesenchymal stem cells. Toxicol Lett. 2012 Oct 17;214(2):145-53. doi: 10.1016/j.toxlet.2012.08.015. Epub 2012 Aug 30.
99 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
100 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
101 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
102 NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
103 Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
104 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
105 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
106 The role of MITF and Mcl-1 proteins in the antiproliferative and proapoptotic effect of ciprofloxacin in amelanotic melanoma cells: In silico and in vitro study. Toxicol In Vitro. 2020 Aug;66:104884. doi: 10.1016/j.tiv.2020.104884. Epub 2020 May 8.
107 Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
108 Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation. Br J Cancer. 2011 Jul 12;105(2):221-30. doi: 10.1038/bjc.2011.229.
109 D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
110 Anti-cancer properties of glucosamine-hydrochloride in YD-8 human oral cancer cells: Induction of the caspase-dependent apoptosis and down-regulation of HIF-1. Toxicol In Vitro. 2012 Feb;26(1):42-50. doi: 10.1016/j.tiv.2011.10.005. Epub 2011 Oct 13.
111 Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase p1-1. Clin Cancer Res. 2012 Dec 15;18(24):6690-701. doi: 10.1158/1078-0432.CCR-12-0770. Epub 2012 Oct 18.
112 Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
113 Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
114 Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
115 In vitro aromatic bioactivation of the weak estrogen E(2)alpha and genesis of DNA adducts. Steroids. 2005 Mar;70(3):161-72. doi: 10.1016/j.steroids.2004.11.004.
116 Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr;33(4):489-94.
117 Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1. Drug Metab Dispos. 2004 Aug;32(8):840-7.
118 Apoptosis contributes to the cytotoxicity induced by amodiaquine and its major metabolite N-desethylamodiaquine in hepatic cells. Toxicol In Vitro. 2020 Feb;62:104669. doi: 10.1016/j.tiv.2019.104669. Epub 2019 Oct 16.
119 Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. doi: 10.1158/0008-5472.CAN-07-6381.
120 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
121 Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells. J Biochem Mol Toxicol. 2020 Feb;34(2):e22433. doi: 10.1002/jbt.22433. Epub 2020 Jan 9.
122 A cell impedance-based real-time in vitro assay to assess the toxicity of amphotericin B formulations. Toxicol Appl Pharmacol. 2017 Nov 1;334:18-23. doi: 10.1016/j.taap.2017.08.017. Epub 2017 Sep 1.
123 CBD Promotes Oral Ulcer Healing via Inhibiting CMPK2-Mediated Inflammasome. J Dent Res. 2022 Feb;101(2):206-215. doi: 10.1177/00220345211024528. Epub 2021 Jul 16.
124 Anti-inflammatory effects of the GABA(B) receptor agonist baclofen in allergic contact dermatitis. Exp Dermatol. 2010 Jul 1;19(7):661-6. doi: 10.1111/j.1600-0625.2010.01076.x. Epub 2010 Feb 25.
125 Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways. World J Gastrointest Oncol. 2022 Feb 15;14(2):450-477. doi: 10.4251/wjgo.v14.i2.450.
126 Sulfasalazine unveils a contact-independent HSV-TK/ganciclovir gene therapy bystander effect in malignant gliomas. Int J Oncol. 2007 Jan;30(1):283-90.
127 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
128 C-Reactive protein levels over time and cardiovascular risk in HIV-infected individuals suppressed on an indinavir-based regimen: AIDS Clinical Trials Group 5056s. AIDS. 2004 Dec 3;18(18):2434-7.
129 Simvastatin combined with ramipril treatment in hypercholesterolemic patients. Hypertension. 2004 Aug;44(2):180-5. doi: 10.1161/01.HYP.0000133310.42762.25. Epub 2004 Jun 7.
130 The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells. Eur J Pharmacol. 2007 Feb 28;557(2-3):221-9.
131 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
132 Inhibition of Bruton tyrosine kinase in patients with severe COVID-19. Sci Immunol. 2020 Jun 5;5(48):eabd0110. doi: 10.1126/sciimmunol.abd0110. Epub 2020 Jun 5.
133 The influence of alclofenac treatment on acute-phase proteins, plasma tryptophan, and erythrocyte sedimentation rate in patients with rheumatoid arthritis. Curr Med Res Opin. 1975;3(5):286-97. doi: 10.1185/03007997509114779.
134 Intractable insomnia after cessation of treatment with thalidomide. Gastroenterology. 2001 May;120(6):1567-8. doi: 10.1053/gast.2001.24495.
135 Effects of hormone treatment on hemostasis variables. Climacteric. 2007 Oct;10 Suppl 2:32-7. doi: 10.1080/13697130701598548.
136 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
137 Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42.
138 Anti-androgenic effect of 6-formylindolo[3,2-b]carbazole (FICZ) in LNCaP cells is mediated by the aryl hydrocarbon-androgen receptors cross-talk. Steroids. 2020 Jan;153:108508. doi: 10.1016/j.steroids.2019.108508. Epub 2019 Oct 3.
139 Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition. Arch Toxicol. 2008 Dec;82(12):909-21.
140 Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density. J Bone Miner Res. 2005 Feb;20(2):232-9. doi: 10.1359/JBMR.041110. Epub 2004 Nov 16.
141 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
142 Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 1999 Feb 1;59(3):607-14.
143 Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
144 The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol. Arch Toxicol. 2013 Apr;87(4):633-43.
145 Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Gastroenterology. 2004 Nov;127(5):1436-45.
146 Mechanisms of dexamethasone-induced disturbed sleep and fatigue in paediatric patients receiving treatment for ALL. Eur J Cancer. 2010 Jul;46(10):1848-55. doi: 10.1016/j.ejca.2010.03.026. Epub 2010 Apr 17.
147 Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
148 ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
149 (9)-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7-Stimulated Human Coculture. J Pharmacol Exp Ther. 2019 Oct;371(1):191-201. doi: 10.1124/jpet.119.260661. Epub 2019 Aug 5.
150 Blood cell oxidative stress precedes hemolysis in whole blood-liver slice co-cultures of rat, dog, and human tissues. Toxicol Appl Pharmacol. 2010 May 1;244(3):354-65. doi: 10.1016/j.taap.2010.01.017. Epub 2010 Feb 6.
151 Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
152 Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol. 2012 May;57(5):483-90. doi: 10.1016/j.archoralbio.2011.10.007. Epub 2011 Nov 25.
153 Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
154 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
155 Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
156 Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med. 2000 Jan;161(1):249-56. doi: 10.1164/ajrccm.161.1.9804096.
157 Docosahexaenoic acid regulates gene expression in HUVEC cells treated with polycyclic aromatic hydrocarbons. Toxicol Lett. 2015 Jul 16;236(2):75-81.
158 Etoposide induces necrosis through p53-mediated antiapoptosis in human kidney proximal tubule cells. Toxicol Sci. 2015 Nov;148(1):204-19.
159 Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. Br J Nutr. 2006 Nov;96(5):811-9.
160 Mitochondrial involvement in schizophrenia and other functional psychoses. Neurochem Res. 1996 Sep;21(9):995-1004.
161 Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression. Eur Neuropsychopharmacol. 2007 Dec;17(12):774-80.
162 Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer. Cancer Res. 2006 Feb 15;66(4):2067-73.
163 A2E selectively induces cox-2 in ARPE-19 and human neural cells. Curr Eye Res. 2006 Mar;31(3):259-63.
164 Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: triggering the differentiation syndrome. Blood. 2009 Dec 24;114(27):5512-21. doi: 10.1182/blood-2009-02-204834. Epub 2009 Oct 14.
165 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
166 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
167 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
168 Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
169 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
170 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
171 Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells. Carcinogenesis. 2006 May;27(5):916-24. doi: 10.1093/carcin/bgi312. Epub 2005 Dec 16.
172 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
173 Proteomic analysis of anti-cancer effects by paclitaxel treatment in cervical cancer cells. Gynecol Oncol. 2005 Jul;98(1):45-53. doi: 10.1016/j.ygyno.2005.04.010.
174 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
175 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
176 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
177 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
178 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
179 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
180 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
181 Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
182 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
183 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
184 A genomic approach to predict synergistic combinations for breast cancer treatment. Pharmacogenomics J. 2013 Feb;13(1):94-104. doi: 10.1038/tpj.2011.48. Epub 2011 Nov 15.
185 Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer. Mol Oncol. 2011 Oct;5(5):438-53. doi: 10.1016/j.molonc.2011.07.003. Epub 2011 Jul 26.
186 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
187 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
188 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
189 Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner. Carcinogenesis. 2009 Aug;30(8):1320-9. doi: 10.1093/carcin/bgp138. Epub 2009 Jun 5.
190 Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
191 The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
192 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
193 Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells. Toxicol Appl Pharmacol. 2017 Sep 15;331:154-163.
194 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
195 Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
196 Effects of NO-1886 (Ibrolipim), a lipoprotein lipase-promoting agent, on gene induction of cytochrome P450s, carboxylesterases, and sulfotransferases in primary cultures of human hepatocytes. Drug Metab Pharmacokinet. 2004 Dec;19(6):422-9.
197 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
198 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
199 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
200 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
201 ON 01910.Na is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress. Clin Cancer Res. 2012 Apr 1;18(7):1979-91. doi: 10.1158/1078-0432.CCR-11-2113. Epub 2012 Feb 20.
202 Microarray analyses in dendritic cells reveal potential biomarkers for chemical-induced skin sensitization. Mol Immunol. 2007 May;44(12):3222-33.
203 Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma. Int J Cancer. 2015 May 1;136(9):2055-64.
204 Comparison of transcriptome expression alterations by chronic exposure to low-dose bisphenol A in different subtypes of breast cancer cells. Toxicol Appl Pharmacol. 2019 Dec 15;385:114814. doi: 10.1016/j.taap.2019.114814. Epub 2019 Nov 9.
205 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
206 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
207 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
208 Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
209 Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134. doi: 10.1016/j.envres.2019.03.035. Epub 2019 Mar 18.
210 Gene expression profiles in HPV-immortalized human cervical cells treated with the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Chem Biol Interact. 2009 Feb 12;177(3):173-80. doi: 10.1016/j.cbi.2008.10.051. Epub 2008 Nov 6.
211 Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
212 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
213 Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
214 Quercetin acts via the G3BP1/YWHAZ axis to inhibit glycolysis and proliferation in oral squamous cell carcinoma. Toxicol Mech Methods. 2023 Feb;33(2):141-150. doi: 10.1080/15376516.2022.2103480. Epub 2022 Aug 9.
215 Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
216 1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells. Cell Struct Funct. 2005;30(1):1-6. doi: 10.1247/csf.30.1.
217 Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22.
218 Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
219 Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
220 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
221 Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3). Cell Biochem Funct. 2011 Mar;29(2):87-95. doi: 10.1002/cbf.1725. Epub 2011 Feb 9.
222 Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: role of nuclear factor-kappaB and reactive oxygen species. J Cell Biochem. 2005 Aug 1;95(5):955-69. doi: 10.1002/jcb.20452.
223 Atorvastatin affects several angiogenic mediators in human endothelial cells. Endothelium. 2005 Sep-Dec;12(5-6):233-41.
224 Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
225 Regulatory role of nitric oxide on monocyte-derived dendritic cell functions. J Interferon Cytokine Res. 2003 Aug;23(8):423-31. doi: 10.1089/107999003322277838.
226 Direct evidence for immunomodulatory properties of ribavirin on T-cell reactivity to hepatitis C virus. Antiviral Res. 2007 Jul;75(1):36-42. doi: 10.1016/j.antiviral.2006.11.008. Epub 2006 Dec 13.
227 Differential effects of three antibiotics on T helper cell cytokine expression. J Antimicrob Chemother. 2005 Sep;56(3):502-6. doi: 10.1093/jac/dki251. Epub 2005 Jul 8.
228 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
229 Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. J Immunol. 2008 May 15;180(10):6988-96. doi: 10.4049/jimmunol.180.10.6988.
230 The flavonoid, quercetin, differentially regulates Th-1 (IFNgamma) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells. Biochim Biophys Acta. 2002 Dec 16;1593(1):29-36. doi: 10.1016/s0167-4889(02)00328-2.
231 [Effects of vitamin A on the differentiation, maturation and functions of dendritic cells from cord blood]. Zhonghua Er Ke Za Zhi. 2004 May;42(5):340-3.
232 Effect of zidovudine therapy in patients with HIV infection on endogenous interferon plasma levels and the hepatic cytochrome P450 enzyme system. Chemotherapy. 1998 May-Jun;44(3):174-80. doi: 10.1159/000007112.
233 Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury. Chem Res Toxicol. 2016 Nov 21;29(11):1793-1795. doi: 10.1021/acs.chemrestox.6b00393. Epub 2016 Nov 9.
234 Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
235 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
236 Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
237 Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
238 Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. Arch Toxicol. 2018 Jun;92(6):2043-2054. doi: 10.1007/s00204-018-2199-7. Epub 2018 Mar 29.
239 Spironolactone induces apoptosis in human mononuclear cells. Association between apoptosis and cytokine suppression. Apoptosis. 2006 Apr;11(4):573-9. doi: 10.1007/s10495-006-4919-3.
240 Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFB and AhR and EGFR-ERK pathway. Toxicol Appl Pharmacol. 2011 Sep 1;255(2):138-49.
241 13-cis retinoic acid inhibits development and progression of chronic allograft nephropathy. Am J Pathol. 2005 Jul;167(1):285-98. doi: 10.1016/S0002-9440(10)62973-2.
242 Characterization of drug-specific signaling between primary human hepatocytes and immune cells. Toxicol Sci. 2017 Jul 1;158(1):76-89.
243 Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
244 Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors. Arthritis Rheum. 2012 Dec;64(12):3856-66. doi: 10.1002/art.37691.
245 Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
246 Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes. Mol Cell Biol. 2017 May 16;37(11):e00079-17. doi: 10.1128/MCB.00079-17. Print 2017 Jun 1.
247 Growth-suppressive effect of non-steroidal anti-inflammatory drugs on 11 colon-cancer cell lines and fluorescence differential display of genes whose expression is influenced by sulindac. Int J Cancer. 2000 Dec 15;88(6):873-80. doi: 10.1002/1097-0215(20001215)88:6<873::aid-ijc6>3.0.co;2-b.
248 [Construction of subtracted cDNA library in human Jurkat T cell line induced by arsenic trioxide in vitro]. Zhonghua Yu Fang Yi Xue Za Zhi. 2003 Nov;37(6):403-7.
249 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
250 Expression pattern of cisplatin-induced metallothionein isoforms in squamous cell carcinoma. Anticancer Res. 2003 Jan-Feb;23(1A):299-303.
251 Identification of novel activators of the metal responsive transcription factor (MTF-1) using a gene expression biomarker in a microarray compendium. Metallomics. 2020 Sep 23;12(9):1400-1415. doi: 10.1039/d0mt00071j.
252 Expression of antioxidant proteins in human intestinal Caco-2 cells treated with dietary flavonoids. Cancer Lett. 1999 Nov 15;146(2):161-7.
253 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
254 Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
255 JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
256 DNA methylation inhibits p53-mediated survivin repression. Oncogene. 2009 May 14;28(19):2046-50. doi: 10.1038/onc.2009.62. Epub 2009 Apr 13.
257 Gene alterations of ovarian cancer cells expressing estrogen receptors by estrogen and bisphenol a using microarray analysis. Lab Anim Res. 2011 Jun;27(2):99-107. doi: 10.5625/lar.2011.27.2.99. Epub 2011 Jun 22.
258 Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
259 Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
260 Bisphenol A Exposure Changes the Transcriptomic and Proteomic Dynamics of Human Retinoblastoma Y79 Cells. Genes (Basel). 2021 Feb 11;12(2):264. doi: 10.3390/genes12020264.
261 Role of antioxidant systems in human androgen-independent prostate cancer cells. Prostate. 2000 May 1;43(2):144-9. doi: 10.1002/(sici)1097-0045(20000501)43:2<144::aid-pros9>3.0.co;2-h.
262 Cytotoxic Effects of Cannabinoids on Human HT-29 Colorectal Adenocarcinoma Cells: Different Mechanisms of THC, CBD, and CB83. Int J Mol Sci. 2020 Aug 1;21(15):5533. doi: 10.3390/ijms21155533.
263 Selenium deficiency alters epithelial cell morphology and responses to influenza. Free Radic Biol Med. 2007 Jun 15;42(12):1826-37.
264 Hepatocellular peroxisomes in human alcoholic and drug-induced hepatitis: a quantitative study. Hepatology. 1991 Nov;14(5):811-7.
265 Antioxidant enzyme and malondialdehyde values in social phobia before and after citalopram treatment. Eur Arch Psychiatry Clin Neurosci. 2004 Aug;254(4):231-5.
266 The effect of statins on lipids peroxidation and activities of antioxidants enzymes in patients with dyslipidemia. Przegl Lek. 2006;63(9):738-42.
267 Cytokine mRNA profiles in cultured human skin component cells exposed to various chemicals: a simulation model of epicutaneous stimuli induced by skin barrier perturbation in comparison with that due to exposure to haptens or irritant. J Dermatol Sci. 2001 Jun;26(2):85-93. doi: 10.1016/s0923-1811(00)00165-1.
268 Effects of luteolin, quercetin and baicalein on immunoglobulin E-mediated mediator release from human cultured mast cells. Clin Exp Allergy. 2000 Apr;30(4):501-8. doi: 10.1046/j.1365-2222.2000.00768.x.
269 Altered cytokine profiles of human retinal pigment epithelium: oxidant injury and replicative senescence. Mol Vis. 2013;19:718-28. Epub 2013 Mar 21.
270 Combination of thalidomide and cisplatin in an head and neck squamous cell carcinomas model results in an enhanced antiangiogenic activity in vitro and in vivo. Int J Cancer. 2007 Oct 15;121(8):1697-704. doi: 10.1002/ijc.22867.
271 Human corneal epithelial cell functional responses to inflammatory agents and their antagonists. Invest Ophthalmol Vis Sci. 1998 Dec;39(13):2562-71.
272 Increased inflammasome related gene expression profile in PBMC may facilitate T helper 17 cell induction in multiple sclerosis. Mol Immunol. 2015 Feb;63(2):521-9. doi: 10.1016/j.molimm.2014.10.008.
273 Acetylcholine and nicotine stimulate the release of granulocyte-macrophage colony stimulating factor from cultured human bronchial epithelial cells. Naunyn Schmiedebergs Arch Pharmacol. 1998 Apr;357(4):472-5. doi: 10.1007/pl00005195.
274 Kaempferol and quercetin stimulate granulocyte-macrophage colony-stimulating factor secretion in human prostate cancer cells. Mol Cell Endocrinol. 2008 Jun 11;287(1-2):57-64. doi: 10.1016/j.mce.2008.01.015. Epub 2008 Feb 3.
275 P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
276 Epinephrine upregulates superoxide dismutase in human coronary artery endothelial cells. Free Radic Biol Med. 2001 Jan 15;30(2):148-53.
277 Cissus quadrangularis ethanol extract upregulates superoxide dismutase, glutathione peroxidase and endothelial nitric oxide synthase expression in hydrogen peroxide-injured human ECV304 cells. J Ethnopharmacol. 2012 Sep 28;143(2):664-72.
278 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
279 Manganese superoxide dismutase is a promising target for enhancing chemosensitivity of basal-like breast carcinoma. Antioxid Redox Signal. 2014 May 20;20(15):2326-46. doi: 10.1089/ars.2013.5295. Epub 2013 Nov 14.
280 HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med. 2011 Mar 24;364(12):1134-43. doi: 10.1056/NEJMoa1013297.
281 Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese. Pharmacogenomics. 2010 Mar;11(3):349-56. doi: 10.2217/pgs.09.162.
282 Positive and negative associations of HLA class I alleles with allopurinol-induced SCARs in Koreans. Pharmacogenet Genomics. 2011 May;21(5):303-7. doi: 10.1097/FPC.0b013e32834282b8.
283 A study of HLA class I and class II 4-digit allele level in Stevens-Johnson syndrome and toxic epidermal necrolysis. Int J Immunogenet. 2011 Aug;38(4):303-9. doi: 10.1111/j.1744-313X.2011.01011.x. Epub 2011 May 4.
284 HLA alleles influence the clinical signature of amoxicillin-clavulanate hepatotoxicity. PLoS One. 2013 Jul 9;8(7):e68111. doi: 10.1371/journal.pone.0068111. Print 2013.
285 Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case-control study. Pharmacogenomics J. 2008 Feb;8(1):29-33. doi: 10.1038/sj.tpj.6500442. Epub 2007 Mar 6.
286 Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
287 Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
288 Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray. Cancer Lett. 2005 Apr 8;220(2):197-210.
289 MiR-99a and MiR-491 Regulate Cisplatin Resistance in Human Gastric Cancer Cells by Targeting CAPNS1. Int J Biol Sci. 2016 Nov 5;12(12):1437-1447. doi: 10.7150/ijbs.16529. eCollection 2016.
290 p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
291 Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
292 Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
293 Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
294 Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
295 Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. Nucleic Acids Res. 2009 Jan;37(1):78-95. doi: 10.1093/nar/gkn910. Epub 2008 Nov 16.
296 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
297 Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
298 Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
299 A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. Cutan Ocul Toxicol. 2010 Sep;29(3):171-92.
300 Arsenic trioxide (ATO) influences the gene expression of metallothioneins in human glioblastoma cells. Biol Trace Elem Res. 2012 Dec;149(3):331-9.
301 Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan;92(1):469-485.
302 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
303 Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines. Cancer Res. 2005 May 1;65(9):3837-45.
304 Computational discovery of niclosamide ethanolamine, a repurposed drug candidate that reduces growth of hepatocellular carcinoma cells initro and in mice by inhibiting cell division cycle 37 signaling. Gastroenterology. 2017 Jun;152(8):2022-2036.
305 Glucocorticoids inhibit cell death in ovarian cancer and up-regulate caspase inhibitor cIAP2. Clin Cancer Res. 2005 Sep 1;11(17):6325-32. doi: 10.1158/1078-0432.CCR-05-0182.
306 Capturing time-dependent activation of genes and stress-response pathways using transcriptomics in iPSC-derived renal proximal tubule cells. Cell Biol Toxicol. 2023 Aug;39(4):1773-1793. doi: 10.1007/s10565-022-09783-5. Epub 2022 Dec 31.
307 Metabolomics of oxidative stress: Nrf2 independent depletion of NAD or increases of sugar alcohols. Toxicol Appl Pharmacol. 2022 May 1;442:115949. doi: 10.1016/j.taap.2022.115949. Epub 2022 Feb 25.
308 Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
309 A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3378-83.
310 The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance. Chem Biol Interact. 2012 Jan 5;195(1):52-60.
311 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
312 [Effects of As2O3 on tissue factor, plasminogen activator inhibitor-1 and -2 expression in NB4, HL-60 and THP-1 cells]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2003 Oct;34(4):645-9.
313 Effects of aspirin on metastasis-associated gene expression detected by cDNA microarray. Acta Pharmacol Sin. 2004 Oct;25(10):1327-33.
314 Dicloxacillin and erythromycin at high concentrations increase ICAM-1 expression by endothelial cells: a possible factor in the pathogenesis of infusion phlebitis. J Antimicrob Chemother. 2004 Feb;53(2):174-9. doi: 10.1093/jac/dkh056. Epub 2004 Jan 16.
315 Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. FASEB J. 2012 Apr;26(4):1535-48. doi: 10.1096/fj.11-198184. Epub 2011 Dec 23.
316 The effect of fexofenadine on expression of intercellular adhesion molecule 1 and induction of apoptosis on peripheral eosinophils. Allergy Asthma Proc. 2005 Jul-Aug;26(4):292-8.
317 Antiallergic effects of H1-receptor antagonists. Allergy. 2000;55 Suppl 64:17-27. doi: 10.1034/j.1398-9995.2000.00803.x.
318 Correlation of sICAM-1 and sVCAM-1 level with biochemical, histological and viral findings in chronic hepatitis C after interferon-alpha + ribavirin therapy. Rom J Gastroenterol. 2003 Jun;12(2):91-5.
319 Some non-sensitizers upregulate CD54 expression by activation of the NLRP3 inflammasome in THP-1 cells. J Toxicol Sci. 2019;44(3):213-224. doi: 10.2131/jts.44.213.
320 Dimethyl Fumarate Inhibits the Nuclear Factor B Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. J Biol Chem. 2016 Feb 12;291(7):3639-47. doi: 10.1074/jbc.M115.679704. Epub 2015 Dec 18.
321 cDNA microarray analysis of isogenic paclitaxel- and doxorubicin-resistant breast tumor cell lines reveals distinct drug-specific genetic signatures of resistance. Breast Cancer Res Treat. 2006 Mar;96(1):17-39. doi: 10.1007/s10549-005-9026-6. Epub 2005 Dec 2.
322 Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
323 Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49. doi: 10.1016/j.placenta.2019.10.008. Epub 2019 Oct 17.
324 Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
325 Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
326 Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
327 Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation. EMBO Rep. 2007 Apr;8(4):394-400. doi: 10.1038/sj.embor.7400909. Epub 2007 Feb 23.
328 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
329 Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine. Clin Pharmacol Ther. 2006 Nov;80(5):440-456.
330 Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
331 Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol Toxicol. 2012 Apr;28(2):69-87.
332 Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
333 Sp1 and Sp3 transcription factors regulate the basal expression of human microsomal epoxide hydrolase (EPHX1) through interaction with the E1b far upstream promoter. Gene. 2014 Feb 15;536(1):135-44. doi: 10.1016/j.gene.2013.11.053. Epub 2013 Dec 4.
334 Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation. Ann Rheum Dis. 2016 Feb;75(2):439-48. doi: 10.1136/annrheumdis-2014-206305. Epub 2015 Jan 9.
335 A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
336 Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. Int J Mol Sci. 2016 Dec 23;18(1):26. doi: 10.3390/ijms18010026.
337 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
338 Magnitude and time course of platelet inhibition with Aggrenox and Aspirin in patients after ischemic stroke: the AGgrenox versus Aspirin Therapy Evaluation (AGATE) trial. Eur J Pharmacol. 2004 Sep 24;499(3):315-24. doi: 10.1016/j.ejphar.2004.07.114.
339 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
340 Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake. Obesity (Silver Spring). 2010 Jan;18(1):27-34. doi: 10.1038/oby.2009.208. Epub 2009 Jun 25.
341 Cholinergic drugs inhibit in?vitro megakaryopoiesis via the alpha7-nicotinic acetylcholine receptor. Platelets. 2011;22(5):390-5. doi: 10.3109/09537104.2010.551304. Epub 2011 Mar 9.
342 Real-time PCR analysis of the apoptosis related genes in ATRA treated APL t(15;17) patients. Exp Mol Med. 2003 Oct 31;35(5):454-9. doi: 10.1038/emm.2003.59.
343 Epigenetic activation of O-linked -N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia. EBioMedicine. 2020 Apr;54:102678. doi: 10.1016/j.ebiom.2020.102678. Epub 2020 Apr 6.
344 Histamine downregulates CD14 expression via H2 receptors on human monocytes. Clin Immunol. 2003 Sep;108(3):274-81. doi: 10.1016/s1521-6616(03)00140-2.
345 The anti-proliferative effect of calcitriol on HL-60 cells is neutralized by uraemic biological fluids. Nephrol Dial Transplant. 2001 Feb;16(2):246-52. doi: 10.1093/ndt/16.2.246.
346 Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC). Front Microbiol. 2015 Dec 22;6:1452. doi: 10.3389/fmicb.2015.01452. eCollection 2015.
347 Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system. (Comparison with steroids). Int Immunopharmacol. 2001 Jun;1(6):1219-26. doi: 10.1016/s1567-5769(01)00059-5.
348 Effects of theophylline, dexamethasone and salbutamol on cytokine gene expression in human peripheral blood CD4+ T-cells. Eur Respir J. 1999 Nov;14(5):1106-12. doi: 10.1183/09031936.99.14511069.
349 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
350 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
351 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
352 MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
353 Nitric oxide-induced apoptosis in lymphoblastoid and fibroblast cells dependent on the phosphorylation and activation of p53. Cancer Res. 2005 Jul 15;65(14):6097-104. doi: 10.1158/0008-5472.CAN-04-4254.
354 Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids. Toxicol Mech Methods. 2023 Jun;33(5):401-410. doi: 10.1080/15376516.2022.2156005. Epub 2022 Dec 19.
355 The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Blood. 2008 Mar 15;111(6):3097-107.
356 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
357 Targeting MYC dependence in cancer by inhibiting BET bromodomains. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16669-74. doi: 10.1073/pnas.1108190108. Epub 2011 Sep 26.
358 Gene expression profiling of human primary astrocytes exposed to manganese chloride indicates selective effects on several functions of the cells. Neurotoxicology. 2007 May;28(3):478-89.
359 Zinc induces chemokine and inflammatory cytokine release from human promonocytes. J Hazard Mater. 2011 Nov 30;196:335-41. doi: 10.1016/j.jhazmat.2011.09.035. Epub 2011 Sep 19.
360 Enhanced production of nitric oxide by bone marrow cells and increased sensitivity to macrophage colony-stimulating factor (CSF) and granulocyte-macrophage CSF after benzene treatment of mice. Blood. 1994 Jun 1;83(11):3255-63.
361 Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. Pharmacogenet Genomics. 2006 Apr;16(4):287-96. doi: 10.1097/01.fpc.0000189800.88596.7a.
362 Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
363 Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
364 Identification of human cell responses to benzene and benzene metabolites. Genomics. 2007 Sep;90(3):324-33.
365 Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents. Leuk Res. 2010 Jul;34(7):917-24. doi: 10.1016/j.leukres.2009.12.002. Epub 2010 Feb 8.
366 Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis. Int J Cancer. 2004 Mar 20;109(2):220-9. doi: 10.1002/ijc.11692.
367 Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
368 Lon protease and eiF2 are involved in acute, but not prolonged, antiretroviral induced stress response in HepG2 cells. Chem Biol Interact. 2016 May 25;252:82-6. doi: 10.1016/j.cbi.2016.03.021. Epub 2016 Apr 1.
369 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
370 Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line. Mol Cancer Ther. 2009 May;8(5):1197-206.
371 Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
372 K-RAS transformation in prostate epithelial cell overcomes H2O2-induced apoptosis via upregulation of gamma-glutamyltransferase-2. Toxicol In Vitro. 2012 Apr;26(3):429-34. doi: 10.1016/j.tiv.2012.01.013. Epub 2012 Jan 17.
373 High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities. Arch Toxicol. 2017 Mar;91(3):1367-1383. doi: 10.1007/s00204-016-1781-0. Epub 2016 Jun 29.
374 Enhanced GRP78 protein expression via the IRE1/ASK1/p38 MAPK pathway during As(2)O(3)-induced endoplasmic reticulum stress in BEAS-2B cells. Toxicology. 2021 Oct;462:152962. doi: 10.1016/j.tox.2021.152962. Epub 2021 Sep 21.
375 [Simvastatin-induced apoptosis of K562 cells is mediated by endoplasmic reticulum stress]. Yao Xue Xue Bao. 2008 Apr;43(4):371-7.
376 Chronic oxycodone induces integrated stress response in rat brain. BMC Neurosci. 2015 Sep 16;16:58. doi: 10.1186/s12868-015-0197-8.
377 Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin. Toxicol Mech Methods. 2017 Mar;27(3):165-172. doi: 10.1080/15376516.2016.1273424. Epub 2017 Jan 8.
378 Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. Eur Rev Med Pharmacol Sci. 2016;20(6):1203-13.
379 Thalidomide alters c-MYB and PIM-1 signaling in K-562 cells. Pharmacol Res. 2006 Aug;54(2):91-6. doi: 10.1016/j.phrs.2006.02.010. Epub 2006 Mar 8.
380 p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells. Neuro Oncol. 2012 Jul;14(7):870-81. doi: 10.1093/neuonc/nos114. Epub 2012 Jun 18.
381 In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells. Food Chem Toxicol. 2022 Jan;159:112722. doi: 10.1016/j.fct.2021.112722. Epub 2021 Dec 3.
382 Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
383 JNK1 is required for sulindac-mediated inhibition of cell proliferation and induction of apoptosis in vitro and in vivo. Eur J Pharmacol. 2007 Apr 10;560(2-3):95-100. doi: 10.1016/j.ejphar.2007.01.020. Epub 2007 Jan 19.
384 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
385 Simvastatin inhibits cell growth and induces apoptosis and G0/G1 cell cycle arrest in hepatic cancer cells. Int J Mol Med. 2010 Nov;26(5):735-41. doi: 10.3892/ijmm_00000520.
386 A gene signature-based approach identifies thioridazine as an inhibitor of phosphatidylinositol-3'-kinase (PI3K)/AKT pathway in ovarian cancer cells. Gynecol Oncol. 2011 Jan;120(1):121-7. doi: 10.1016/j.ygyno.2010.10.003. Epub 2010 Oct 29.
387 Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
388 Effects of formaldehyde, acetaldehyde, benzoyl peroxide, and hydrogen peroxide on cultured normal human bronchial epithelial cells. Cancer Res. 1985 Jun;45(6):2522-6.
389 Methotrexate induced differentiation in colon cancer cells is primarily due to purine deprivation. J Cell Biochem. 2006 Sep 1;99(1):146-55. doi: 10.1002/jcb.20908.
390 Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells. Carcinogenesis. 2001 Mar;22(3):409-14. doi: 10.1093/carcin/22.3.409.
391 DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
392 Adrenergic modulation of cardiac development in the rat: effects of prenatal exposure to propranolol via continuous maternal infusion. J Dev Physiol. 1990 May;13(5):243-9.
393 Effects of Imatinib Mesylate (Gleevec) on human islet NF-kappaB activation and chemokine production in vitro. PLoS One. 2011;6(9):e24831. doi: 10.1371/journal.pone.0024831. Epub 2011 Sep 14.
394 Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
395 Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation. Toxicol Appl Pharmacol. 2021 Mar 15;415:115450. doi: 10.1016/j.taap.2021.115450. Epub 2021 Feb 9.
396 Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.
397 Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism. Chem Biol Interact. 2023 Jan 5;369:110278. doi: 10.1016/j.cbi.2022.110278. Epub 2022 Nov 22.
398 Acinar cell-specific knockout of the PTHrP gene decreases the proinflammatory and profibrotic responses in pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G533-49. doi: 10.1152/ajpgi.00428.2013. Epub 2014 Jul 17.
399 All-trans retinoic acid induced hypercalcemia in a patient with acute promyelocytic leukemia: its relation to increased PTH-rP. Int J Hematol. 1994 Feb;59(2):143-4.
400 Parathyroid hormone-related protein varies with sex and androgen status in nonsmall cell lung cancer. Cancer. 2007 Sep 15;110(6):1313-20. doi: 10.1002/cncr.22922.
401 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
402 The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation. Int J Hematol. 2015 Jul;102(1):12-24. doi: 10.1007/s12185-015-1776-2. Epub 2015 Mar 11.
403 Profiling transcriptomes of human SH-SY5Y neuroblastoma cells exposed to maleic acid. PeerJ. 2017 Apr 5;5:e3175.
404 CD34+ derived macrophage and dendritic cells display differential responses to paraquat. Toxicol In Vitro. 2021 Sep;75:105198. doi: 10.1016/j.tiv.2021.105198. Epub 2021 Jun 9.
405 Effects of different anti-asthmatic agents on induced sputum and eosinophil cationic protein in mild asthmatics. Respirology. 2004 Nov;9(4):514-20. doi: 10.1111/j.1440-1843.2004.00631.x.
406 Salmeterol decreases eosinophilic cationic protein and rescue medication in patients inhaling beclomethasone dipropionate: preliminary study in mild and moderate asthma in Trinidad, West Indies. Int J Clin Pharmacol Res. 2003;23(2-3):69-74.
407 Asthma therapy modulates priming-associated blood eosinophil responsiveness in allergic asthmatics. Eur Respir J. 1999 Oct;14(4):915-22. doi: 10.1034/j.1399-3003.1999.14d31.x.
408 Formoterol compared with beclomethasone and placebo on allergen-induced asthmatic responses. Am Rev Respir Dis. 1992 Nov;146(5 Pt 1):1156-60. doi: 10.1164/ajrccm/146.5_Pt_1.1156.
409 Effect of inhaled beclomethasone dipropionate and budesonide dry powder on pulmonary function and serum eosinophil cationic protein in adult asthmatics. J Investig Allergol Clin Immunol. 1999 Jul-Aug;9(4):241-7.
410 Direct and indirect effects of androgens on survival of hematopoietic progenitor cells in vitro. J Korean Med Sci. 2005 Jun;20(3):409-16. doi: 10.3346/jkms.2005.20.3.409.
411 Isoproterenol effects evaluated in heart slices of human and rat in comparison to rat heart in vivo. Toxicol Appl Pharmacol. 2014 Jan 15;274(2):302-12.
412 Pregnancy exposure to synthetic phenols and placental DNA methylation - An epigenome-wide association study in male infants from the EDEN cohort. Environ Pollut. 2021 Dec 1;290:118024. doi: 10.1016/j.envpol.2021.118024. Epub 2021 Aug 21.
413 Comparative proteomics reveals concordant and discordant biochemical effects of caffeine versus epigallocatechin-3-gallate in human endothelial cells. Toxicol Appl Pharmacol. 2019 Sep 1;378:114621. doi: 10.1016/j.taap.2019.114621. Epub 2019 Jun 10.
414 Crosstalk between alveolar macrophages and alveolar epithelial cells/fibroblasts contributes to the pulmonary toxicity of gefitinib. Toxicol Lett. 2021 Mar 1;338:1-9. doi: 10.1016/j.toxlet.2020.11.011. Epub 2020 Nov 25.
415 Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
416 Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
417 Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients. Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1194-9. doi: 10.1161/01.atv.0000022694.16328.cc.
418 A copper-hydrogen peroxide redox system induces dityrosine cross-links and chemokine oligomerisation. Cytokine. 2011 Dec;56(3):669-75. doi: 10.1016/j.cyto.2011.08.025. Epub 2011 Oct 1.
419 Simvastatin down regulates mRNA expression of RANTES and CCR5 in posttransplant renal recipients with hyperlipidemia. Transplant Proc. 2006 Nov;38(9):2899-904. doi: 10.1016/j.transproceed.2006.08.136.
420 2,3,7,8-tetrachlorodibenzo-p-dioxin augments the modulation of gene expression mediated by the thyroid hormone receptor. Toxicol Appl Pharmacol. 2004 Feb 1;194(3):201-10. doi: 10.1016/j.taap.2003.09.010.
421 Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
422 High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth. Clin Cancer Res. 2009 Oct 1;15(19):6070-8.
423 Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells. Proteomics. 2004 Jul;4(7):2160-74.
424 Glucosamine-induced endoplasmic reticulum stress promotes ApoB100 degradation: evidence for Grp78-mediated targeting to proteasomal degradation. Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):571-7. doi: 10.1161/01.ATV.0000154142.61859.94. Epub 2004 Dec 23.
425 Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
426 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
427 G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J Biol Chem. 1993 Apr 15;268(11):8298-308.
428 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
429 Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
430 Synthesis and antitumor evaluation of nitrovinyl biphenyls: anticancer agents based on allocolchicines. ChemMedChem. 2011 May 2;6(5):859-68. doi: 10.1002/cmdc.201100019. Epub 2011 Apr 6.
431 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
432 Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
433 Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment. Pharmaceutics. 2021 Sep 7;13(9):1415. doi: 10.3390/pharmaceutics13091415.
434 Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
435 Pentosan polysulfate decreases proliferation and extracellular matrix deposition by vascular smooth muscle cells isolated from failed hemodialysis access grafts. Clin Nephrol. 2000 Aug;54(2):121-7.
436 Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
437 Matrix metalloproteinase-9 is involved in chronic lymphocytic leukemia cell response to fludarabine and arsenic trioxide. PLoS One. 2014 Jun 23;9(6):e99993. doi: 10.1371/journal.pone.0099993. eCollection 2014.
438 Simvastatin, an HMG-CoA reductase inhibitor, reduced the expression of matrix metalloproteinase-9 (Gelatinase B) in osteoblastic cells and HT1080 fibrosarcoma cells. J Pharmacol Sci. 2004 Apr;94(4):403-9. doi: 10.1254/jphs.94.403.
439 Arsenic trioxide induces differentiation of cancer stem cells in hepatocellular carcinoma through inhibition of LIF/JAK1/STAT3 and NF-kB signaling pathways synergistically. Clin Transl Med. 2021 Feb;11(2):e335. doi: 10.1002/ctm2.335.
440 Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
441 Antileishmanial drugs cause up-regulation of interferon-gamma receptor 1, not only in the monocytes of visceral leishmaniasis cases but also in cultured THP1 cells. Ann Trop Med Parasitol. 2003 Apr;97(3):245-57. doi: 10.1179/000349803235001714.
442 Antitumor effect of aspirin in glioblastoma cells by modulation of -catenin/T-cell factor-mediated transcriptional activity. J Neurosurg. 2011 Oct;115(4):780-8. doi: 10.3171/2011.5.JNS113. Epub 2011 Jul 1.
443 Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer. JCI Insight. 2018 Sep 6;3(17):e121497. doi: 10.1172/jci.insight.121497. eCollection 2018 Sep 6.
444 Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes. Arch Toxicol. 2018 Jan;92(1):371-381.
445 Enhanced cytotoxicity of bioreductive antitumor agents with dimethyl fumarate in human glioblastoma cells. Anticancer Drugs. 2005 Feb;16(2):167-74.
446 Simvastatin protects dopaminergic neurons against MPP+-induced oxidative stress and regulates the endogenous anti-oxidant system through ERK. Cell Physiol Biochem. 2018;51(4):1957-1968.
447 Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin. Toxicol Lett. 2001 Feb 3;119(1):49-57.
448 Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
449 Promotion of the articular cartilage proteoglycan degradation by T-2 toxin and selenium protective effect. J Zhejiang Univ Sci B. 2008 Jan;9(1):22-33. doi: 10.1631/jzus.B071322.
450 Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
451 Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44. J Biol Chem. 2011 Apr 1;286(13):11314-27. doi: 10.1074/jbc.M110.193714. Epub 2011 Jan 3.
452 Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer. Curr Pharm Des. 2013;19(5):940-50.
453 Single-nucleotide polymorphisms in P450 oxidoreductase and peroxisome proliferator-activated receptor- are associated with the development of new-onset diabetes after transplantation in kidney transplant recipients treated with tacrolimus. Pharmacogenet Genomics. 2013 Dec;23(12):649-57. doi: 10.1097/FPC.0000000000000001.
454 StJohn's wort extracts and some of their constituents potently inhibit ultimate carcinogen formation from benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1. Cancer Res. 2003 Nov 15;63(22):8062-8.
455 Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006 Jan 10;24(2):274-87. doi: 10.1200/JCO.2005.02.9405. Epub 2005 Dec 19.
456 Ouabain induces apoptotic cell death in human prostate DU 145 cancer cells through DNA damage and TRAIL pathways. Environ Toxicol. 2019 Dec;34(12):1329-1339. doi: 10.1002/tox.22834. Epub 2019 Aug 21.
457 Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage. Carcinogenesis. 2014 Mar;35(3):692-702. doi: 10.1093/carcin/bgt366. Epub 2013 Nov 5.
458 Induction of the DNA repair gene O6-methylguanine-DNA methyltransferase by dexamethasone in glioblastomas. J Neurosurg. 2004 Oct;101(4):659-63. doi: 10.3171/jns.2004.101.4.0659.
459 Phenytoin may increase the efficacy of temozolomide by methylating DNA-repair enzyme, O6-methylguanine-DNA methyltransferase in patients with glioblastoma. Med Hypotheses. 2005;65(4):819-20. doi: 10.1016/j.mehy.2005.04.007.
460 Pharmacokinetic, biochemical and clinical effects of dimethyltriazenoimidazole-4-carboxamide-bischloroethylnitrosourea combination therapy in patients with advanced breast cancer. Int J Cancer. 2003 Feb 20;103(5):686-92. doi: 10.1002/ijc.10849.
461 Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N'-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells. Mol Pharmacol. 2008 Aug;74(2):517-26. doi: 10.1124/mol.107.043620. Epub 2008 May 20.
462 Arsenic trioxide induces Hsp70 expression via reactive oxygen species and JNK pathway in MDA231 cells. Life Sci. 2005 Oct 14;77(22):2783-93. doi: 10.1016/j.lfs.2005.04.024.
463 Effect of all-trans retinoic acid on sodium/iodide symporter expression, radioiodine uptake and gene expression profiles in a human anaplastic thyroid carcinoma cell line. Nucl Med Biol. 2006 Oct;33(7):875-82. doi: 10.1016/j.nucmedbio.2006.07.004.
464 Selenium is critical for cancer-signaling gene expression but not cell proliferation in human colon Caco-2 cells. Biofactors. 2007;31(3-4):155-64. doi: 10.1002/biof.5520310302.
465 Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Mol Cell Biochem. 2010 Nov;344(1-2):173-84. doi: 10.1007/s11010-010-0540-4. Epub 2010 Jul 25.
466 Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
467 Curcumin reduces the expression of survivin, leading to enhancement of arsenic trioxide-induced apoptosis in myelodysplastic syndrome and leukemia stem-like cells. Oncol Rep. 2016 Sep;36(3):1233-42. doi: 10.3892/or.2016.4944. Epub 2016 Jul 15.
468 DHT and testosterone, but not DHEA or E2, differentially modulate IGF-I, IGFBP-2, and IGFBP-3 in human prostatic stromal cells. Am J Physiol Endocrinol Metab. 2006 May;290(5):E952-60. doi: 10.1152/ajpendo.00451.2005. Epub 2005 Dec 20.
469 Differential protein expression of peroxiredoxin I and II by benzo(a)pyrene and quercetin treatment in 22Rv1 and PrEC prostate cell lines. Toxicol Appl Pharmacol. 2007 Apr 15;220(2):197-210. doi: 10.1016/j.taap.2006.12.030. Epub 2007 Jan 9.
470 Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease. Proteomics. 2008 Apr;8(8):1595-607. doi: 10.1002/pmic.200700556.
471 Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
472 Resveratrol-induced cell growth inhibition and apoptosis is associated with modulation of phosphoglycerate mutase B in human prostate cancer cells: two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis and mass spectrometry evaluation. Cancer Detect Prev. 2004;28(6):443-52. doi: 10.1016/j.cdp.2004.08.009.
473 Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands. Toxicol Lett. 2011 Oct 10;206(2):178-88.
474 Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
475 Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation. J Biol Chem. 2005 Jan 28;280(4):2912-23. doi: 10.1074/jbc.M409524200. Epub 2004 Nov 17.
476 Suppression of mammary carcinoma growth by retinoic acid: proapoptotic genes are targets for retinoic acid receptor and cellular retinoic acid-binding protein II signaling. Cancer Res. 2005 Sep 15;65(18):8193-9. doi: 10.1158/0008-5472.CAN-05-1177.
477 Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
478 Hydroquinone Exposure Worsens Rheumatoid Arthritis through the Activation of the Aryl Hydrocarbon Receptor and Interleukin-17 Pathways. Antioxidants (Basel). 2021 Jun 7;10(6):929. doi: 10.3390/antiox10060929.
479 Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
480 The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
481 Gene expression levels in normal human lymphoblasts with variable sensitivities to arsenite: identification of GGT1 and NFKBIE expression levels as possible biomarkers of susceptibility. Toxicol Appl Pharmacol. 2008 Jan 15;226(2):199-205. doi: 10.1016/j.taap.2007.09.004. Epub 2007 Sep 15.
482 Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
483 Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol Rep. 2006 Jun;15(6):1453-60.
484 The thioredoxin system mediates redox-induced cell death in human colon cancer cells: implications for the mechanism of action of anticancer agents. Cancer Res. 2008 Oct 15;68(20):8269-77. doi: 10.1158/0008-5472.CAN-08-2010.
485 Development of an alternative zebrafish model for drug-induced intestinal toxicity. J Appl Toxicol. 2018 Feb;38(2):259-273. doi: 10.1002/jat.3520. Epub 2017 Oct 13.
486 Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. 2005 Jul 7;5:74. doi: 10.1186/1471-2407-5-74.
487 Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2716-23.
488 Progesterone and calcitriol attenuate inflammatory cytokines CXCL1 and CXCL2 in ovarian and endometrial cancer cells. J Cell Biochem. 2012 Oct;113(10):3143-52. doi: 10.1002/jcb.24191.
489 Considering temozolomide as a novel potential treatment for esophageal cancer. Cancer. 2011 May 1;117(9):2004-16. doi: 10.1002/cncr.25687. Epub 2010 Nov 8.
490 Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
491 Sulindac induces specific degradation of the HPV oncoprotein E7 and causes growth arrest and apoptosis in cervical carcinoma cells. Cancer Lett. 2007 Jan 8;245(1-2):103-11. doi: 10.1016/j.canlet.2005.12.034. Epub 2006 Feb 20.
492 CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models. Genes Cancer. 2014 Jul;5(7-8):261-72. doi: 10.18632/genesandcancer.24.
493 Circulating endothelial progenitor cells in multiple myeloma: implications and significance. Blood. 2005 Apr 15;105(8):3286-94. doi: 10.1182/blood-2004-06-2101. Epub 2004 Dec 23.
494 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
495 Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells. Toxicol Appl Pharmacol. 2009 Feb 1;234(3):345-60.
496 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
497 Changes in gene expressions elicited by physiological concentrations of genistein on human endometrial cancer cells. Mol Carcinog. 2006 Oct;45(10):752-63.
498 Oestrogenic potencies of Zeranol, oestradiol, diethylstilboestrol, Bisphenol-A and genistein: implications for exposure assessment of potential endocrine disrupters. Hum Reprod. 2001 May;16(5):1037-45.
499 Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity. Toxicol Sci. 2011 Dec;124(2):278-90. doi: 10.1093/toxsci/kfr225. Epub 2011 Aug 27.
500 Mapping the dynamics of Nrf2 antioxidant and NFB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses. Toxicol In Vitro. 2022 Oct;84:105419. doi: 10.1016/j.tiv.2022.105419. Epub 2022 Jun 17.
501 The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro. Toxicol Appl Pharmacol. 2020 Mar 15;391:114915. doi: 10.1016/j.taap.2020.114915. Epub 2020 Feb 6.
502 Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer. J Biol Chem. 2003 Nov 28;278(48):47762-75.
503 Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells. Biochem J. 2006 Feb 15;394(Pt 1):317-24.
504 Thyroid hormone responsive genes in cultured human fibroblasts. J Clin Endocrinol Metab. 2005 Feb;90(2):936-43.
505 Regulation of keratinocyte growth factor and scatter factor in cyclosporin-induced gingival overgrowth. J Oral Pathol Med. 2004 Aug;33(7):391-7. doi: 10.1111/j.1600-0714.2004.00223.x.
506 Keratinocyte growth factor is upregulated by the hyperplasia-inducing drug nifedipine. Cytokine. 2000 Oct;12(10):1566-9. doi: 10.1006/cyto.2000.0756.
507 The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. Hum Reprod. 2010 Nov;25(11):2859-69.
508 Molecular mechanisms controlling the rate and specificity of catechol O-methylation by human soluble catechol O-methyltransferase. Mol Pharmacol. 2001 Feb;59(2):393-402. doi: 10.1124/mol.59.2.393.
509 Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT. Sleep. 2010 Aug;33(8):1027-35. doi: 10.1093/sleep/33.8.1027.
510 Tolcapone increases plasma catecholamine levels in patients with Parkinson's disease. Parkinsonism Relat Disord. 2001 Apr;7(2):93-96. doi: 10.1016/s1353-8020(00)00027-4.
511 Ribavirin polarizes human T cell responses towards a Type 1 cytokine profile. J Hepatol. 1999 Mar;30(3):376-82. doi: 10.1016/s0168-8278(99)80093-2.
512 Immune regulatory effects of simvastatin on regulatory T cell-mediated tumour immune tolerance. Clin Exp Immunol. 2010 Aug;161(2):298-305. doi: 10.1111/j.1365-2249.2010.04170.x. Epub 2010 May 18.
513 Quercetin's influence on exercise-induced changes in plasma cytokines and muscle and leukocyte cytokine mRNA. J Appl Physiol (1985). 2007 Nov;103(5):1728-35. doi: 10.1152/japplphysiol.00707.2007. Epub 2007 Aug 23.
514 The effects of 1 month antihypertensive treatment with perindopril, bisoprolol or both on the ex vivo ability of monocytes to secrete inflammatory cytokines. Int J Clin Pharmacol Ther. 2009 Nov;47(11):686-94. doi: 10.5414/cpp47686.
515 Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses. Immunology. 2007 Jun;121(2):266-75. doi: 10.1111/j.1365-2567.2007.02574.x. Epub 2007 Mar 7.
516 Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation. Blood. 2008 Feb 1;111(3):1366-77. doi: 10.1182/blood-2007-04-084814. Epub 2007 Oct 25.
517 Pattern of expression of apoptosis and inflammatory genes in humans exposed to arsenic and/or fluoride. Sci Total Environ. 2010 Jan 15;408(4):760-7. doi: 10.1016/j.scitotenv.2009.11.016. Epub 2009 Dec 4.
518 Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer. Cancer Res. 2007 May 15;67(10):5033-41.
519 Human Mincle Binds to Cholesterol Crystals and Triggers Innate Immune Responses. J Biol Chem. 2015 Oct 16;290(42):25322-32. doi: 10.1074/jbc.M115.645234. Epub 2015 Aug 20.
520 Inhibition of Super-Enhancer Activity in Autoinflammatory Site-Derived T Cells Reduces Disease-Associated Gene Expression. Cell Rep. 2015 Sep 29;12(12):1986-96. doi: 10.1016/j.celrep.2015.08.046. Epub 2015 Sep 17.
521 Aryl hydrocarbon receptor- and calcium-dependent induction of the chemokine CCL1 by the environmental contaminant benzo[a]pyrene. J Biol Chem. 2006 Jul 21;281(29):19906-15. doi: 10.1074/jbc.M601192200. Epub 2006 May 5.
522 Activation of PPAR and inhibition of cell proliferation reduces key proteins associated with the basal subtype of bladder cancer in As3+-transformed UROtsa cells. PLoS One. 2020 Aug 21;15(8):e0237976. doi: 10.1371/journal.pone.0237976. eCollection 2020.
523 Direct and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes. BMC Immunol. 2006 Nov 21;7:27. doi: 10.1186/1471-2172-7-27.
524 Cannabinoid receptor type 2 agonists induce transcription of the mu-opioid receptor gene in Jurkat T cells. Mol Pharmacol. 2006 Apr;69(4):1486-91. doi: 10.1124/mol.105.018325. Epub 2006 Jan 24.
525 Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
526 Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
527 Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
528 Sulforaphane-induced apoptosis in human leukemia HL-60 cells through extrinsic and intrinsic signal pathways and altering associated genes expression assayed by cDNA microarray. Environ Toxicol. 2017 Jan;32(1):311-328.
529 Chromium III histidinate exposure modulates gene expression in HaCaT human keratinocytes exposed to oxidative stress. Biol Trace Elem Res. 2010 Oct;137(1):23-39.
530 A dual role of p21waf1/cip1 gene in apoptosis of HEp-2 treated with cisplatin or methotrexate. Cancer Gene Ther. 2008 Sep;15(9):576-90. doi: 10.1038/cgt.2008.28. Epub 2008 May 16.
531 Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Int J Mol Sci. 2023 Mar 15;24(6):5604. doi: 10.3390/ijms24065604.
532 The Effect of GADD45a on Furazolidone-Induced S-Phase Cell-Cycle Arrest in Human Hepatoma G2 Cells. J Biochem Mol Toxicol. 2015 Oct;29(10):489-495. doi: 10.1002/jbt.21719. Epub 2015 Jun 11.
533 Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells. Oncogene. 2004 Jun 3;23(26):4614-23. doi: 10.1038/sj.onc.1207598.
534 Linalool is a PPARalpha ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome. J Lipid Res. 2014 Jun;55(6):1098-110.
535 Comparison of the effects of pioglitazone and rosiglitazone on macrophage foam cell formation. Biochem Biophys Res Commun. 2004 Oct 22;323(3):782-8.
536 Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
537 Microtubules are required for NF-kappaB nuclear translocation in neuroblastoma IMR-32 cells: modulation by zinc. J Neurochem. 2006 Oct;99(2):402-15. doi: 10.1111/j.1471-4159.2006.04005.x.
538 Protein phosphatase 2A interacts with and directly dephosphorylates RelA. J Biol Chem. 2001 Dec 21;276(51):47828-33. doi: 10.1074/jbc.M106103200. Epub 2001 Oct 8.
539 Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells. Mol Pharmacol. 2008 Aug;74(2):476-84.
540 Prevention of deoxycholate-induced gastric apoptosis by aspirin: roles of NF-kappaB and PKC signaling. J Surg Res. 2008 Mar;145(1):66-73. doi: 10.1016/j.jss.2007.04.039. Epub 2007 Jul 20.
541 Arsenic suppresses GDF1 expression via ROS-dependent downregulation of specificity protein 1. Environ Pollut. 2021 Feb 15;271:116302. doi: 10.1016/j.envpol.2020.116302. Epub 2020 Dec 15.
542 Effects of tobacco compounds on gene expression in fetal lung fibroblasts. Environ Toxicol. 2008 Aug;23(4):423-34.
543 Interactive gene expression pattern in prostate cancer cells exposed to phenolic antioxidants. Life Sci. 2002 Mar 1;70(15):1821-39.
544 Histamine inhibits the production of interleukin-12 through interaction with H2 receptors. J Clin Invest. 1998 Nov 15;102(10):1866-73. doi: 10.1172/JCI3692.
545 Systemic drugs inducing non-immediate cutaneous adverse reactions and contact sensitizers evoke similar responses in THP-1 cells. J Appl Toxicol. 2015 Apr;35(4):398-406. doi: 10.1002/jat.3033. Epub 2014 Aug 4.
546 Induction of the endoplasmic reticulum stress protein GADD153/CHOP by capsaicin in prostate PC-3 cells: a microarray study. Biochem Biophys Res Commun. 2008 Aug 8;372(4):785-91.
547 Prostaglandin E(2) is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer. Blood. 2001 Jun 1;97(11):3466-9. doi: 10.1182/blood.v97.11.3466.
548 Effect of serum and antioxidants on the immunogenicity of protein kinase C-activated chronic lymphocytic leukemia cells. J Immunother. 2005 Jan-Feb;28(1):28-39. doi: 10.1097/00002371-200501000-00004.
549 Cannabidiol Protects Human Skin Keratinocytes from Hydrogen-Peroxide-Induced Oxidative Stress via Modulation of the Caspase-1-IL-1 Axis. J Nat Prod. 2021 May 28;84(5):1563-1572. doi: 10.1021/acs.jnatprod.1c00083. Epub 2021 May 6.
550 Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment. J Pharmacol Exp Ther. 2014 Mar;348(3):360-71. doi: 10.1124/jpet.113.210054. Epub 2013 Dec 17.
551 Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes. Toxicol Lett. 2023 Mar 1;376:39-50. doi: 10.1016/j.toxlet.2023.01.005. Epub 2023 Jan 13.
552 Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
553 Effect of nephrotoxicants and hepatotoxicants on gene expression profile in human peripheral blood mononuclear cells. Biochem Biophys Res Commun. 2010 Oct 15;401(2):245-50. doi: 10.1016/j.bbrc.2010.09.039. Epub 2010 Sep 16.
554 Adenosine and Cordycepin Accelerate Tissue Remodeling Process through Adenosine Receptor Mediated Wnt/-Catenin Pathway Stimulation by Regulating GSK3b Activity. Int J Mol Sci. 2021 May 25;22(11):5571. doi: 10.3390/ijms22115571.
555 A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression. Exp Hematol. 2015 May;43(5):404-413.e5. doi: 10.1016/j.exphem.2015.01.005. Epub 2015 Jan 26.
556 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
557 Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
558 Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
559 Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
560 The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
561 Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
562 Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci. 2014 Jun;139(2):328-37. doi: 10.1093/toxsci/kfu053. Epub 2014 Mar 27.
563 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
564 Role of phenytoin in wound healing: microarray analysis of early transcriptional responses in human dermal fibroblasts. Biochem Biophys Res Commun. 2004 Feb 13;314(3):661-6. doi: 10.1016/j.bbrc.2003.12.146.
565 Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
566 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
567 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
568 Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
569 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
570 Redistribution of cell cycle by arsenic trioxide is associated with demethylation and expression changes of cell cycle related genes in acute promyelocytic leukemia cell line (NB4). Ann Hematol. 2018 Jan;97(1):83-93. doi: 10.1007/s00277-017-3163-y. Epub 2017 Nov 20.
571 In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
572 ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2007 May;6(5):1579-87. doi: 10.1158/1535-7163.MCT-06-0814.
573 Constitutive gene expression predisposes morphogen-mediated cell fate responses of NT2/D1 and 27X-1 human embryonal carcinoma cells. Stem Cells. 2007 Mar;25(3):771-8. doi: 10.1634/stemcells.2006-0271. Epub 2006 Nov 30.
574 Arsenic trioxide inhibits P-glycoprotein expression in multidrug-resistant human leukemia K562/ADM cell line that overexpresses mdr-1 gene and enhances their chemotherapeutic sensitivity. Zhonghua Xue Ye Xue Za Zhi. 2003 Jan;24(1):28-31.
575 Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
576 Inhibition of nicotinamide phosphoribosyltransferase and depletion of nicotinamide adenine dinucleotide contribute to arsenic trioxide suppression of oral squamous cell carcinoma. Toxicol Appl Pharmacol. 2017 Sep 15;331:54-61. doi: 10.1016/j.taap.2017.05.008. Epub 2017 May 10.
577 Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
578 Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells. Biochem Biophys Res Commun. 2002 Feb 8;290(5):1427-33. doi: 10.1006/bbrc.2002.6367.
579 Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter. Free Radic Biol Med. 2002 Mar 1;32(5):386-93. doi: 10.1016/s0891-5849(01)00812-7.
580 Glycidamide and cis-2-butene-1,4-dial (BDA) as potential carcinogens and promoters of liver cancer - An in vitro study. Food Chem Toxicol. 2022 Aug;166:113251. doi: 10.1016/j.fct.2022.113251. Epub 2022 Jun 21.
581 Essential role of Nrf2 in protection against hydroquinone- and benzoquinone-induced cytotoxicity. Toxicol In Vitro. 2011 Mar;25(2):521-9.
582 Ursodeoxycholic acid induces glutathione synthesis through activation of PI3K/Akt pathway in HepG2 cells. Biochem Pharmacol. 2009 Mar 1;77(5):858-66. doi: 10.1016/j.bcp.2008.11.012. Epub 2008 Nov 25.
583 Petit E, Langouet S, Akhdar H, Nicolas-Nicolaz C, Guillouzo A, Morel F. Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes. Toxicol In Vitro. 2008;22(3):632-642. [PMID: 18222062]
584 Interplay between cellular methyl metabolism and adaptive efflux during oncogenic transformation from chronic arsenic exposure in human cells. J Biol Chem. 2008 Jul 11;283(28):19342-50.
585 Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
586 Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
587 Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod. 2011 Jul;26(7):1813-25.
588 Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
589 Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environ Health Perspect. 2003 May;111(6):825-35.
590 Cysteamine suppresses invasion, metastasis and prolongs survival by inhibiting matrix metalloproteinases in a mouse model of human pancreatic cancer. PLoS One. 2012;7(4):e34437. doi: 10.1371/journal.pone.0034437. Epub 2012 Apr 20.
591 Inactivation of RASSF2A by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma. Int J Cancer. 2007 Jan 1;120(1):32-8. doi: 10.1002/ijc.22185.
592 Evaluation of developmental toxicity using undifferentiated human embryonic stem cells. J Appl Toxicol. 2015 Feb;35(2):205-18.
593 Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: role of myeloperoxidase and arylamine free radicals. Chem Biol Interact. 2015 Sep 5;239:129-38.
594 Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
595 Gene expression changes associated with altered growth and differentiation in benzo[a]pyrene or arsenic exposed normal human epidermal keratinocytes. J Appl Toxicol. 2008 May;28(4):491-508.
596 Chemicals with weak skin sensitizing properties can be identified using low-density microarrays on immature dendritic cells. Toxicol Lett. 2007 Nov 1;174(1-3):98-109. doi: 10.1016/j.toxlet.2007.08.015. Epub 2007 Sep 5.
597 Cocaine and sigma-1 receptors modulate HIV infection, chemokine receptors, and the HPA axis in the huPBL-SCID model. J Leukoc Biol. 2005 Dec;78(6):1198-203. doi: 10.1189/jlb.0405219. Epub 2005 Oct 4.
598 Maturation of human monocyte-derived dendritic cells (MoDCs) in the presence of prostaglandin E2 optimizes CD4 and CD8 T cell-mediated responses to protein antigens: role of PGE2 in chemokine and cytokine expression by MoDCs. Int Immunol. 2005 Dec;17(12):1561-72. doi: 10.1093/intimm/dxh335. Epub 2005 Nov 22.
599 Aryl hydrocarbon receptor signaling modifies Toll-like receptor-regulated responses in human dendritic cells. Arch Toxicol. 2017 May;91(5):2209-2221.
600 Prediction of the contact sensitizing potential of chemicals using analysis of gene expression changes in human THP-1 monocytes. Toxicol Lett. 2010 Nov 10;199(1):51-9.
601 Decreased urinary beta-defensin-1 expression as a biomarker of response to arsenic. Toxicol Sci. 2008 Nov;106(1):74-82. doi: 10.1093/toxsci/kfn104. Epub 2008 May 28.
602 Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
603 Omeprazole inhibits pancreatic cancer cell invasion through a nongenomic aryl hydrocarbon receptor pathway. Chem Res Toxicol. 2015 May 18;28(5):907-18.
604 Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
605 Arsenic trioxide inhibits CXCR4-mediated metastasis by interfering miR-520h/PP2A/NF-B signaling in cervical cancer. Ann Surg Oncol. 2014 Dec;21 Suppl 4:S687-95. doi: 10.1245/s10434-014-3812-5. Epub 2014 Jul 22.
606 Etodolac induces apoptosis and inhibits cell adhesion to bone marrow stromal cells in human myeloma cells. Leuk Res. 2006 Feb;30(2):123-35. doi: 10.1016/j.leukres.2005.06.009. Epub 2005 Jul 25.
607 Cardiac toxicity from ethanol exposure in human-induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci. 2019 May 1;169(1):280-292.
608 Folic acid induces cell type-specific changes in the transcriptome of breast cancer cell lines: a proof-of-concept study. J Nutr Sci. 2016 Apr 26;5:e17. doi: 10.1017/jns.2016.8. eCollection 2016.
609 Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells. Biochemistry. 2007 Aug 7;46(31):8920-32. doi: 10.1021/bi7000328. Epub 2007 Jul 14.
610 Selective nonsteroidal anti-inflammatory drugs induce thymosin beta-4 and alter actin cytoskeletal organization in human colorectal cancer cells. J Pharmacol Exp Ther. 2004 Dec;311(3):885-91. doi: 10.1124/jpet.104.070664. Epub 2004 Aug 3.
611 5-Fluorouracil: identification of novel downstream mediators of tumour response. Anticancer Res. 2004 Mar-Apr;24(2A):417-23.
612 Transcriptomic alterations induced by Ochratoxin A in rat and human renal proximal tubular in vitro models and comparison to a rat in vivo model. Arch Toxicol. 2012 Apr;86(4):571-89.
613 ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis. Blood. 2004 Jan 1;103(1):194-207.
614 Transcriptomic analysis of human primary bronchial epithelial cells after chloropicrin treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.
615 Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. J Proteome Res. 2009 Jun;8(6):3006-19.
616 Hydroquinone-induced miR-122 down-regulation elicits ADAM17 up-regulation, leading to increased soluble TNF- production in human leukemia cells with expressed Bcr/Abl. Biochem Pharmacol. 2013 Sep 1;86(5):620-31. doi: 10.1016/j.bcp.2013.06.009. Epub 2013 Jun 20.
617 The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-alpha converting enzyme (TACE). J Bone Miner Res. 2004 Jan;19(1):147-54. doi: 10.1359/jbmr.2004.19.1.147.
618 Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines. Chem Biol Interact. 2010 Oct 6;188(1):214-9.
619 Application of cDNA microarray to the study of arsenic-induced liver diseases in the population of Guizhou, China. Toxicol Sci. 2001 Jan;59(1):185-92.
620 Role of DNA Repair Pathways in Response to Zidovudine-induced DNA Damage in Immortalized Human Liver THLE2 Cells. Int J Biomed Sci. 2013 Mar;9(1):18-25.
621 Comparison of Drug Metabolism and Its Related Hepatotoxic Effects in HepaRG, Cryopreserved Human Hepatocytes, and HepG2 Cell Cultures. Biol Pharm Bull. 2018 May 1;41(5):722-732. doi: 10.1248/bpb.b17-00913. Epub 2018 Feb 14.
622 Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
623 Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells. Clin Exp Immunol. 2012 Apr;168(1):113-24. doi: 10.1111/j.1365-2249.2011.04549.x.
624 PCI-24781 induces caspase and reactive oxygen species-dependent apoptosis through NF-kappaB mechanisms and is synergistic with bortezomib in lymphoma cells. Clin Cancer Res. 2009 May 15;15(10):3354-65. doi: 10.1158/1078-0432.CCR-08-2365. Epub 2009 May 5.
625 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
626 Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
627 MiR-146a affects the alteration in myeloid differentiation induced by hydroquinone in human CD34(+) hematopoietic progenitor cells and HL-60 cells. Toxicol Res (Camb). 2016 Feb 16;5(3):848-858. doi: 10.1039/c5tx00419e. eCollection 2016 May 1.
628 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
629 Differential effects of statins on relevant functions of human monocyte-derived dendritic cells. J Leukoc Biol. 2006 Mar;79(3):529-38. doi: 10.1189/jlb.0205064. Epub 2005 Dec 30.
630 Vitamin D Counteracts an IL-23-Dependent IL-17A(+)IFN-(+) Response Driven by Urban Particulate Matter. Am J Respir Cell Mol Biol. 2017 Sep;57(3):355-366. doi: 10.1165/rcmb.2016-0409OC.
631 Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane. Bone. 2007 Apr;40(4):876-87. doi: 10.1016/j.bone.2006.11.029. Epub 2006 Dec 28.
632 Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells. Neurosci Lett. 2006 Mar 13;395(3):185-90. doi: 10.1016/j.neulet.2005.10.096. Epub 2005 Dec 1.
633 Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
634 Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver. Arch Toxicol. 2022 Oct;96(10):2739-2754. doi: 10.1007/s00204-022-03338-7. Epub 2022 Jul 26.
635 Immediate up-regulation of the calcium-binding protein S100P and its involvement in the cytokinin-induced differentiation of human myeloid leukemia cells. Biochim Biophys Acta. 2005 Sep 10;1745(2):156-65.
636 Nicotine stimulates urokinase-type plasminogen activator receptor expression and cell invasiveness through mitogen-activated protein kinase and reactive oxygen species signaling in ECV304 endothelial cells. Toxicol Appl Pharmacol. 2012 Mar 1;259(2):248-56. doi: 10.1016/j.taap.2012.01.002. Epub 2012 Jan 9.
637 [Clinical study on the fibrinolytic activity in patients with acute promyelocytic leukemia]. Zhonghua Xue Ye Xue Za Zhi. 2009 Mar;30(3):145-9.
638 Aspirin upregulates expression of urokinase type plasminogen activator receptor (uPAR) gene in human colon cancer cells through AP1. Biochem Biophys Res Commun. 2006 Sep 22;348(2):618-27. doi: 10.1016/j.bbrc.2006.07.098. Epub 2006 Jul 28.
639 Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
640 Transcriptional responses to estrogen and progesterone in mammary gland identify networks regulating p53 activity. Endocrinology. 2008 Oct;149(10):4809-20. doi: 10.1210/en.2008-0035. Epub 2008 Jun 12.
641 Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.
642 Differential effects of omega-3 and omega-6 Fatty acids on gene expression in breast cancer cells. Breast Cancer Res Treat. 2007 Jan;101(1):7-16. doi: 10.1007/s10549-006-9269-x. Epub 2006 Jul 6.
643 CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
644 Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
645 Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia. J Exp Med. 2010 Apr 12;207(4):731-50. doi: 10.1084/jem.20091488. Epub 2010 Apr 5.
646 Peroxisome proliferator activated receptor gamma (PPAR-gama) ligand pioglitazone regulated gene networks in term human primary trophoblast cells. Reprod Toxicol. 2018 Oct;81:99-107.
647 In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
648 Impairment of hypoxia-induced HIF-1 signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor. Arch Toxicol. 2016 May;90(5):1141-50. doi: 10.1007/s00204-015-1549-y. Epub 2015 Jun 17.
649 Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene. 2005 Feb 3;24(6):980-91. doi: 10.1038/sj.onc.1208095.
650 Marked regression of liver metastasis by combined therapy of ultrasound-mediated NF kappaB-decoy transfer and transportal injection of paclitaxel, in mouse. Int J Cancer. 2008 Apr 1;122(7):1645-56. doi: 10.1002/ijc.23280.
651 Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis. Mol Cancer Ther. 2004 Jan;3(1):71-84.
652 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
653 Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. Med Oncol. 2010 Sep;27(3):833-42. doi: 10.1007/s12032-009-9294-9. Epub 2009 Sep 10.
654 Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
655 Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochem Pharmacol. 2011 Feb 15;81(4):510-7. doi: 10.1016/j.bcp.2010.11.014. Epub 2010 Nov 27.
656 Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c. Biochim Biophys Acta. 2010 Apr;1803(4):452-67. doi: 10.1016/j.bbamcr.2009.12.005. Epub 2010 Jan 4.
657 Adipogenic Effects and Gene Expression Profiling of Firemaster? 550 Components in Human Primary Preadipocytes. Environ Health Perspect. 2017 Sep 14;125(9):097013. doi: 10.1289/EHP1318.
658 Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
659 Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):117-27.
660 Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
661 Sp sites contribute to basal and inducible expression of the human TNIP1 (TNF-inducible protein 3-interacting protein 1) promoter. Biochem J. 2013 Jun 15;452(3):519-29. doi: 10.1042/BJ20121666.
662 Transcriptomics and methylomics of CD4-positive T cells in arsenic-exposed women. Arch Toxicol. 2017 May;91(5):2067-2078. doi: 10.1007/s00204-016-1879-4. Epub 2016 Nov 12.
663 Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell. 2004 Mar;15(3):1262-72. doi: 10.1091/mbc.e03-06-0360. Epub 2003 Dec 29.
664 Arsenic trioxide induces cell cycle arrest and affects Trk receptor expression in human neuroblastoma SK-N-SH cells. Biol Res. 2018 Jun 13;51(1):18. doi: 10.1186/s40659-018-0167-6.
665 RNA sequence analysis of inducible pluripotent stem cell-derived cardiomyocytes reveals altered expression of DNA damage and cell cycle genes in response to doxorubicin. Toxicol Appl Pharmacol. 2018 Oct 1;356:44-53.
666 A novel long noncoding RNA AK001796 acts as an oncogene and is involved in cell growth inhibition by resveratrol in lung cancer. Toxicol Appl Pharmacol. 2015 Jun 1;285(2):79-88.
667 Madecassoside ameliorates cisplatin-induced nephrotoxicity by inhibiting activation of the mitogen activated protein kinase pathway. Environ Toxicol. 2023 Jul;38(7):1473-1483. doi: 10.1002/tox.23777. Epub 2023 Apr 23.
668 Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
669 Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38. Chem Biol Interact. 2012 Jan 25;195(2):154-64.
670 Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine. Cancer Sci. 2003 Oct;94(10):886-93.
671 Arsenic trioxide promotes ERK1/2-mediated phosphorylation and degradation of BIM(EL) to attenuate apoptosis in BEAS-2B cells. Chem Biol Interact. 2023 Jan 5;369:110304. doi: 10.1016/j.cbi.2022.110304. Epub 2022 Dec 10.
672 Aspirin-mediated COX-2 transcript stabilization via sustained p38 activation in human intestinal myofibroblasts. Mol Pharmacol. 2004 Feb;65(2):470-8.
673 Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia. Leukemia. 2000 Feb;14(2):262-70. doi: 10.1038/sj.leu.2401650.
674 Fenofibrate induces effective apoptosis in mantle cell lymphoma by inhibiting the TNFalpha/NF-kappaB signaling axis. Leukemia. 2010 Aug;24(8):1476-86. doi: 10.1038/leu.2010.117. Epub 2010 Jun 3.
675 Effect of zoledronic acid on oral fibroblasts and epithelial cells: a potential mechanism of bisphosphonate-associated osteonecrosis. Br J Haematol. 2009 Mar;144(5):667-76. doi: 10.1111/j.1365-2141.2008.07504.x. Epub 2008 Nov 20.
676 Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
677 Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions. BMC Genomics. 2008 Aug 7;9:376.
678 Different pathways are involved in arsenic-trioxide-induced cell proliferation and growth inhibition in human keratinocytes. Skin Pharmacol Physiol. 2010;23(2):68-78. doi: 10.1159/000265677. Epub 2009 Dec 14.
679 Programmed cell death-4 tumor suppressor protein contributes to retinoic acid-induced terminal granulocytic differentiation of human myeloid leukemia cells. Mol Cancer Res. 2007 Jan;5(1):95-108. doi: 10.1158/1541-7786.MCR-06-0125.
680 Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells. J Biol Chem. 2015 Jun 19;290(25):15799-15811. doi: 10.1074/jbc.M115.641167. Epub 2015 May 11.
681 Melinjo (Gnetum gnemon L.) Seed Extract Decreases Serum Uric Acid Levels in Nonobese Japanese Males: A Randomized Controlled Study. Evid Based Complement Alternat Med. 2013;2013:589169. doi: 10.1155/2013/589169. Epub 2013 Dec 17.
682 Cigarette smoke affects keratinocytes SRB1 expression and localization via H2O2 production and HNE protein adducts formation. PLoS One. 2012;7(3):e33592. doi: 10.1371/journal.pone.0033592. Epub 2012 Mar 19.
683 Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells. J Immunol. 2008 Nov 15;181(10):7332-40. doi: 10.4049/jimmunol.181.10.7332.
684 Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding. PLoS One. 2012;7(4):e35895. doi: 10.1371/journal.pone.0035895. Epub 2012 Apr 23.
685 Pregnane X receptor-agonists down-regulate hepatic ATP-binding cassette transporter A1 and scavenger receptor class B type I. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1533-41. doi: 10.1016/j.bbrc.2005.04.071.
686 Stimulation of CD36 and the key effector of reverse cholesterol transport ATP-binding cassette A1 in monocytoid cells by niacin. Biochem Pharmacol. 2004 Feb 1;67(3):411-9. doi: 10.1016/j.bcp.2003.09.014.
687 Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in Caco-2 cells treated with ezetimibe. J Nutr. 2005 Oct;135(10):2305-12. doi: 10.1093/jn/135.10.2305.
688 Analysis of the in vitro synergistic effect of 5-fluorouracil and cisplatin on cervical carcinoma cells. Int J Gynecol Cancer. 2006 May-Jun;16(3):1321-9.
689 Arsenic trioxide induces regulatory functions of plasmacytoid dendritic cells through interferon- inhibition. Acta Pharm Sin B. 2020 Jun;10(6):1061-1072. doi: 10.1016/j.apsb.2020.01.016. Epub 2020 Jan 31.
690 Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
691 Gene expression responses reflecting 5-FU-induced toxicity: Comparison between patient colon tissue and 3D human colon organoids. Toxicol Lett. 2022 Dec 1;371:17-24. doi: 10.1016/j.toxlet.2022.09.013. Epub 2022 Sep 29.
692 Overexpression of glutathione-S-transferase, MGSTII, confers resistance to busulfan and melphalan. Cancer Invest. 2005;23(1):19-25.
693 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
694 Apoptosis induction by 1alpha,25-dihydroxyvitamin D3 in prostate cancer. Mol Cancer Ther. 2002 Jul;1(9):667-77.
695 The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
696 Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies. Toxicol Appl Pharmacol. 2021 Dec 15;433:115792. doi: 10.1016/j.taap.2021.115792. Epub 2021 Nov 3.
697 Proteasome inhibition creates a chromatin landscape favorable to RNA Pol II processivity. J Biol Chem. 2020 Jan 31;295(5):1271-1287. doi: 10.1074/jbc.RA119.011174. Epub 2019 Dec 5.
698 Comparison of quantitation methods in proteomics to define relevant toxicological information on AhR activation of HepG2 cells by BaP. Toxicology. 2021 Jan 30;448:152652. doi: 10.1016/j.tox.2020.152652. Epub 2020 Dec 2.
699 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
700 Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int. 2021 Nov;156:106730. doi: 10.1016/j.envint.2021.106730. Epub 2021 Jun 27.
701 In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions. Basic Clin Pharmacol Toxicol. 2008 Aug;103(2):157-65.
702 Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo. J Asian Nat Prod Res. 2012;14(4):382-95.
703 Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.
704 Stiripentol. Expert Opin Investig Drugs. 2005 Jul;14(7):905-11.
705 Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):843-52.
706 Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor. Drug Metab Dispos. 2003 Nov;31(11):1352-60.
707 Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. J Med Chem. 2005 Jun 2;48(11):3808-15.
708 Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells. Br J Pharmacol. 2013 May;169(1):167-78.
709 Characterizing the genetic basis for nicotine induced cancer development: a transcriptome sequencing study. PLoS One. 2013 Jun 18;8(6):e67252.
710 Transforming growth factor-beta1 inhibits all-trans retinoic acid-induced apoptosis. Leuk Res. 2006 May;30(5):607-23. doi: 10.1016/j.leukres.2005.09.007. Epub 2005 Oct 19.
711 Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms. PLoS One. 2011;6(11):e27306. doi: 10.1371/journal.pone.0027306. Epub 2011 Nov 8.
712 Bupropion, an atypical antidepressant, induces endoplasmic reticulum stress and caspase-dependent cytotoxicity in SH-SY5Y cells. Toxicology. 2011 Jul 11;285(1-2):1-7. doi: 10.1016/j.tox.2011.02.006. Epub 2011 Feb 24.
713 Effects of arsenic trioxide alone and in combination with bortezomib in multiple myeloma RPMI 8266 cells. Asian Pac J Cancer Prev. 2013;14(11):6469-73. doi: 10.7314/apjcp.2013.14.11.6469.
714 Stimulation of erythropoiesis by thalidomide in multiple myeloma patients: its influence on FasL, TRAIL and their receptors on erythroblasts. Haematologica. 2006 Mar;91(3):386-9.
715 The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase. J Biol Chem. 2022 Feb;298(2):101531. doi: 10.1016/j.jbc.2021.101531. Epub 2021 Dec 23.
716 Effect of ellagic acid on the expression of human telomerase reverse transcriptase (hTERT) alpha+beta+ transcript in estrogen receptor-positive MCF-7 breast cancer cells. Clin Biochem. 2009 Sep;42(13-14):1358-62. doi: 10.1016/j.clinbiochem.2009.05.017. Epub 2009 Jun 6.
717 Antiproliferative effects of gefitinib are associated with suppression of E2F-1 expression and telomerase activity. Anticancer Res. 2006 Sep-Oct;26(5A):3387-91.
718 Inhibitory effects of selenium on telomerase activity and hTERT expression in cadmium-transformed 16HBE cells. Biomed Environ Sci. 2007 Aug;20(4):307-12.
719 Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast cancer cells. BMC Cancer. 2010 Jul 22;10:390. doi: 10.1186/1471-2407-10-390.
720 Analysis of telomerase activity and RNA expression in a patient with acute promyelocytic leukemia treated with all-trans retinoic acid. Pediatr Blood Cancer. 2006 Apr;46(4):506-11. doi: 10.1002/pbc.20392.
721 Characterization of the functional and growth properties of long-term cell cultures established from a human somatostatinoma. Endocr Relat Cancer. 2006 Mar;13(1):79-93. doi: 10.1677/erc.1.00988.
722 Characterization of arsenic-induced cytogenetic alterations in acute promyelocytic leukemia cell line, NB4. Med Oncol. 2012 Jun;29(2):1209-16. doi: 10.1007/s12032-011-9946-4. Epub 2011 May 5.
723 The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration. Mol Biol Cell. 2011 Sep;22(17):3032-40. doi: 10.1091/mbc.E11-04-0280. Epub 2011 Jul 7.
724 Differential regulation of vitamin D receptor (VDR) by the p53 Family: p73-dependent induction of VDR upon DNA damage. J Biol Chem. 2007 Oct 12;282(41):29847-54.
725 Role of calcitriol and cortisol on human adipocyte proliferation and oxidative and inflammatory stress: a microarray study. J Nutrigenet Nutrigenomics. 2008;1(1-2):30-48. doi: 10.1159/000109873. Epub 2007 Oct 16.
726 Chronic ethanol exposure induces neuroinflammation in H4 cells through TLR3 / NF-B pathway and anxiety-like behavior in male C57BL/6 mice. Toxicology. 2020 Dec 15;446:152625. doi: 10.1016/j.tox.2020.152625. Epub 2020 Nov 5.
727 Specific molecular interactions of oversulfated chondroitin sulfate E with various heparin-binding growth factors. Implications as a physiological binding partner in the brain and other tissues. J Biol Chem. 2002 Nov 15;277(46):43707-16. doi: 10.1074/jbc.M207105200. Epub 2002 Sep 6.
728 Peripheral blood expression profiles of bone morphogenetic proteins, tumor necrosis factor-superfamily molecules, and transcription factor Runx2 could be used as markers of the form of arthritis, disease activity, and therapeutic responsiveness. J Rheumatol. 2010 Feb;37(2):246-56. doi: 10.3899/jrheum.090167. Epub 2009 Dec 15.
729 Transcription factors specifying dopamine phenotype are decreased in cocaine users. Neuroreport. 2004 Mar 1;15(3):401-4. doi: 10.1097/00001756-200403010-00003.
730 Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food Chem Toxicol. 2020 Feb;136:111047. doi: 10.1016/j.fct.2019.111047. Epub 2019 Dec 12.
731 Toxicogenomics of kojic acid on gene expression profiling of a375 human malignant melanoma cells. Biol Pharm Bull. 2006 Apr;29(4):655-69.
732 Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
733 Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling. Free Radic Biol Med. 2012 Jul 1;53(1):44-50. doi: 10.1016/j.freeradbiomed.2012.04.031. Epub 2012 May 9.
734 Quercetin suppresses pancreatic ductal adenocarcinoma progression via inhibition of SHH and TGF-/Smad signaling pathways. Cell Biol Toxicol. 2021 Jun;37(3):479-496. doi: 10.1007/s10565-020-09562-0. Epub 2020 Oct 17.
735 Inhibition of the cancer stem cells-like properties by arsenic trioxide, involved in the attenuation of endogenous transforming growth factor beta signal. Toxicol Sci. 2015 Jan;143(1):156-64. doi: 10.1093/toxsci/kfu218. Epub 2014 Oct 10.
736 In vitro antitumoral effects of the steroid ouabain on human thyroid papillary carcinoma cell lines. Environ Toxicol. 2021 Jul;36(7):1338-1348. doi: 10.1002/tox.23130. Epub 2021 Mar 24.
737 Aldosterone induces epithelial-mesenchymal transition via ROS of mitochondrial origin. Am J Physiol Renal Physiol. 2007 Sep;293(3):F723-31. doi: 10.1152/ajprenal.00480.2006. Epub 2007 Jun 27.
738 Anti-invasive activity of sanguinarine through modulation of tight junctions and matrix metalloproteinase activities in MDA-MB-231 human breast carcinoma cells. Chem Biol Interact. 2009 May 15;179(2-3):185-91. doi: 10.1016/j.cbi.2008.11.009. Epub 2008 Nov 21.
739 Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells. Environ Health Perspect. 2015 Jan;123(1):80-7. doi: 10.1289/ehp.1408437. Epub 2014 Aug 19.
740 Steroid profiling in H295R cells to identify chemicals potentially disrupting the production of adrenal steroids. Toxicology. 2017 Apr 15;381:51-63.
741 Influences of norepinephrine transporter function on the distribution of sympathetic activity in humans. Hypertension. 2006 Jul;48(1):120-6. doi: 10.1161/01.HYP.0000225424.13138.5d. Epub 2006 May 22.
742 Amiloride, spironolactone, and potassium chloride in thiazide-treated hypertensive patients. Clin Pharmacol Ther. 1980 Apr;27(4):533-43. doi: 10.1038/clpt.1980.75.
743 Simvastatin treatment in subjects at high cardiovascular risk modulates AT1R expression on circulating monocytes and T lymphocytes. J Hypertens. 2008 Jun;26(6):1147-55. doi: 10.1097/HJH.0b013e3282f97dde.
744 Inhibition of cGMP-specific phosphodiesterase type 5 reduces sodium excretion and arterial blood pressure in patients with NaCl retention and ascites. Am J Physiol Renal Physiol. 2005 May;288(5):F1044-52. doi: 10.1152/ajprenal.00142.2004. Epub 2004 Dec 21.
745 Effects of lisinopril on cardiorespiratory, neuroendocrine, and renal function in patients with asymptomatic left ventricular dysfunction. Br Heart J. 1993 Jun;69(6):512-5. doi: 10.1136/hrt.69.6.512.
746 Angiotensin II receptor blockade in normotensive subjects: A direct comparison of three AT1 receptor antagonists. Hypertension. 1999 Mar;33(3):850-5. doi: 10.1161/01.hyp.33.3.850.
747 Discovery of molecular mechanisms of neuroprotection using cell-based bioassays and oligonucleotide arrays. Physiol Genomics. 2002 Oct 29;11(2):45-52. doi: 10.1152/physiolgenomics.00064.2002.
748 Dietary supplementation with the anti-tumour promoter quercetin: its effects on matrix metalloproteinase gene regulation. Mutat Res. 2001 Sep 1;480-481:269-76. doi: 10.1016/s0027-5107(01)00184-1.
749 Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes. Pharmacology. 2009;83(1):18-25. doi: 10.1159/000166183. Epub 2008 Oct 30.
750 Oxidative stress in kidney transplant patients with calcineurin inhibitor-induced hypertension: effect of ramipril. J Cardiovasc Pharmacol. 2002 Oct;40(4):625-31.
751 Antiestrogens induce transforming growth factor beta-mediated immunosuppression in breast cancer. Cancer Res. 2010 Feb 15;70(4):1314-22. doi: 10.1158/0008-5472.CAN-09-3292. Epub 2010 Feb 9.
752 PPAR-alpha ligands inhibit H2O2-mediated activation of transforming growth factor-beta1 in human mesangial cells. Antioxid Redox Signal. 2002 Dec;4(6):877-84. doi: 10.1089/152308602762197416.
753 Cytokine abnormalities in a patient with eosinophilic fasciitis. Ann Allergy Asthma Immunol. 2003 Apr;90(4):452-5. doi: 10.1016/S1081-1206(10)61832-7.
754 Ciprofloxacin decreases survival in HT-29 cells via the induction of TGF-beta1 secretion and enhances the anti-proliferative effect of 5-fluorouracil. Br J Pharmacol. 2009 Jun;157(3):362-70. doi: 10.1111/j.1476-5381.2009.00161.x. Epub 2009 Apr 9.
755 Enhanced apoptosis and transforming growth factor-beta1 expression in colorectal adenomas and carcinomas after Sulindac therapy. Dis Colon Rectum. 2001 Jul;44(7):1008-15. doi: 10.1007/BF02235490.
756 Glucosamine decreases expression of anabolic and catabolic genes in human osteoarthritic cartilage explants. Osteoarthritis Cartilage. 2006 Mar;14(3):250-7. doi: 10.1016/j.joca.2005.10.001. Epub 2005 Nov 18.
757 Parathyroid hormone 1-34 reduces dexamethasone-induced terminal differentiation in human articular chondrocytes. Toxicology. 2016 Aug 10;368-369:116-128.
758 Notoginsenoside R1 inhibits TNF-alpha-induced fibronectin production in smooth muscle cells via the ROS/ERK pathway. Free Radic Biol Med. 2006 May 1;40(9):1664-74. doi: 10.1016/j.freeradbiomed.2006.01.003. Epub 2006 Jan 26.
759 Small Molecule Antipsychotic Aripiprazole Potentiates Ozone-Induced Inflammation in Airway Epithelium. Chem Res Toxicol. 2019 Oct 21;32(10):1997-2005. doi: 10.1021/acs.chemrestox.9b00149. Epub 2019 Sep 11.
760 Peroxisome proliferator-activated receptor-gamma ligands suppress fibronectin gene expression in human lung carcinoma cells: involvement of both CRE and Sp1. Am J Physiol Lung Cell Mol Physiol. 2005 Sep;289(3):L419-28. doi: 10.1152/ajplung.00002.2005. Epub 2005 May 20.
761 Retinoic acid remodels extracellular matrix (ECM) of cultured human fetal palate mesenchymal cells (hFPMCs) through down-regulation of TGF-/Smad signaling. Toxicol Lett. 2014 Mar 3;225(2):208-15. doi: 10.1016/j.toxlet.2013.12.013. Epub 2013 Dec 24.
762 Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway. PLoS One. 2009 Dec 14;4(12):e8294. doi: 10.1371/journal.pone.0008294.
763 An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide. Exp Hematol. 2007 Feb;35(2):252-62.
764 Estrogen-like activity of metals in MCF-7 breast cancer cells. Endocrinology. 2003 Jun;144(6):2425-36. doi: 10.1210/en.2002-221054.
765 Cross-talk between non-genomic and genomic signalling pathways--distinct effect profiles of environmental estrogens. Toxicol Appl Pharmacol. 2010 Jun 1;245(2):160-70. doi: 10.1016/j.taap.2010.02.015. Epub 2010 Mar 4.
766 Bidirectional cross talk between ERalpha and EGFR signalling pathways regulates tamoxifen-resistant growth. Breast Cancer Res Treat. 2006 Mar;96(2):131-46. doi: 10.1007/s10549-005-9070-2. Epub 2005 Oct 27.
767 Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry. Odontology. 2013 Jan;101(1):43-51.
768 The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res. 2005 Jan 1;65(1):18-25.
769 Antitumoral activity of liraglutide, a new DNMT inhibitor in breast cancer cells in vitro and in vivo. Chem Biol Interact. 2021 Nov 1;349:109641. doi: 10.1016/j.cbi.2021.109641. Epub 2021 Sep 14.
770 Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells. Mol Pharmacol. 2001 Sep;60(3):595-602.
771 Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth. Br J Cancer. 2007 Apr 23;96(8):1204-15. doi: 10.1038/sj.bjc.6603705. Epub 2007 Mar 27.
772 Prediction of the combined effects of multiple estrogenic chemicals on MCF-7 human breast cancer cells and a preliminary molecular exploration of the estrogenic proliferative effects and related gene expression. Ecotoxicol Environ Saf. 2018 Sep 30;160:1-9. doi: 10.1016/j.ecoenv.2018.05.025. Epub 2018 May 21.
773 Oral contraceptives, thrombosis and haemostasis. Eur J Obstet Gynecol Reprod Biol. 2001 Apr;95(2):193-7. doi: 10.1016/s0301-2115(00)00489-9.
774 Haemostatic effects of supraphysiological levels of testosterone in normal men. Thromb Haemost. 1995 Aug;74(2):693-7.
775 Clozapine-induced interstitial nephritis - a rare but important complication: a case report. J Med Case Rep. 2009 Aug 27;3:8574. doi: 10.4076/1752-1947-3-8574.
776 Reversible acute renal failure associated with clomipramine-induced interstitial nephritis. Clin Exp Nephrol. 2007 Sep;11(3):241-243. doi: 10.1007/s10157-007-0485-4. Epub 2007 Sep 28.
777 Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4578-83.
778 Prediction of drug-induced liver injury using keratinocytes. J Appl Toxicol. 2017 Jul;37(7):863-872. doi: 10.1002/jat.3435. Epub 2017 Jan 31.
779 ?-adrenoceptors and muscarinic receptors mediate opposing effects on endothelin-1 expression in human lung fibroblasts. Eur J Pharmacol. 2012 Sep 15;691(1-3):218-24. doi: 10.1016/j.ejphar.2012.07.002. Epub 2012 Jul 13.
780 Induction of endothelin-1 expression by oxidative stress in vascular smooth muscle cells. Cardiovasc Pathol. 2001 Nov-Dec;10(6):311-5. doi: 10.1016/s1054-8807(01)00095-3.
781 [Effect of simvastatin on endothelin-1 expression in endothelial cell cultured hypoxically]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Jan;39(1):72-5.
782 Effects of dietary polyphenols on gene expression in human vascular endothelial cells. Proc Nutr Soc. 2008 Feb;67(1):42-7.
783 Nucleoside reverse transcriptase inhibitors induce a mitophagy-associated endothelial cytotoxicity that is reversed by coenzyme Q10 cotreatment. Toxicol Sci. 2013 Aug;134(2):323-34. doi: 10.1093/toxsci/kft105. Epub 2013 May 2.
784 Cardiac toxicity of high-dose cyclophosphamide in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation. Int J Hematol. 2007 Jun;85(5):408-14. doi: 10.1532/IJH97.E0620.
785 Different effects of angiotensin converting enzyme inhibitors on endothelin-1 and nitric oxide balance in human vascular endothelial cells: evidence of an oxidant-sensitive pathway. Mediators Inflamm. 2008;2008:305087. doi: 10.1155/2008/305087. Epub 2008 Dec 1.
786 HL60 cells halted in G1 or S phase differentiate normally. Exp Cell Res. 2002 Nov 15;281(1):28-38. doi: 10.1006/excr.2002.5654.
787 Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
788 SGK1, a potential regulator of c-fms related breast cancer aggressiveness. Clin Exp Metastasis. 2004;21(6):477-83.
789 Resveratrol modulates the phosphoinositide 3-kinase pathway through an estrogen receptor alpha-dependent mechanism: relevance in cell proliferation. Int J Cancer. 2004 Mar 20;109(2):167-73. doi: 10.1002/ijc.11720.
790 Glucosamine sulfate-induced apoptosis in chronic myelogenous leukemia K562 cells is associated with translocation of cathepsin D and downregulation of Bcl-xL. Apoptosis. 2006 Oct;11(10):1851-60. doi: 10.1007/s10495-006-9529-6.
791 Src Family Kinase Inhibitor PP2 Has Different Effects on All-Trans-Retinoic Acid or Arsenic Trioxide-Induced Differentiation of an Acute Promyelocytic Leukemia Cell Line. Cancer Res Treat. 2013 Jun;45(2):126-33. doi: 10.4143/crt.2013.45.2.126. Epub 2013 Jun 30.
792 Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain Res. 2008 Jan 29;1191:1-11.
793 Harnessing autophagy to overcome mitogen-activated protein kinase kinase inhibitor-induced resistance in metastatic melanoma. Br J Dermatol. 2019 Feb;180(2):346-356. doi: 10.1111/bjd.17333. Epub 2018 Nov 25.
794 TAp73 knockout mice show morphological and functional nervous system defects associated with loss of p75 neurotrophin receptor. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18952-7. doi: 10.1073/pnas.1221172110. Epub 2013 Nov 4.
795 A comparison of the effectiveness of selected non-steroidal anti-inflammatory drugs and their derivatives against cancer cells in vitro. Cancer Chemother Pharmacol. 2008 Feb;61(2):203-14. doi: 10.1007/s00280-007-0462-3. Epub 2007 Apr 20.
796 The aryl propionic acid R-flurbiprofen selectively induces p75NTR-dependent decreased survival of prostate tumor cells. Cancer Res. 2007 Apr 1;67(7):3254-62.
797 Arsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulation. PLoS One. 2013 Jul 8;8(7):e69466. doi: 10.1371/journal.pone.0069466. Print 2013.
798 White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol. 2015 Jan;17(1):57-67. doi: 10.1038/ncb3075. Epub 2014 Dec 8.
799 The aquaglyceroporin AQP9 contributes to the sex-specific effects of in utero arsenic exposure on placental gene expression. Environ Health. 2017 Jun 14;16(1):59. doi: 10.1186/s12940-017-0267-8.
800 Down-regulation of Sonic hedgehog signaling pathway activity is involved in 5-fluorouracil-induced apoptosis and motility inhibition in Hep3B cells. Acta Biochim Biophys Sin (Shanghai). 2008 Sep;40(9):819-29.
801 Sonic hedgehog signaling regulates Bcr-Abl expression in human chronic myeloid leukemia cells. Biomed Pharmacother. 2012 Jul;66(5):378-83. doi: 10.1016/j.biopha.2011.12.008. Epub 2012 Feb 16.
802 Oxidative Stress-Protective and Anti-Melanogenic Effects of Loliolide and Ethanol Extract from Fresh Water Green Algae, Prasiola japonica. Int J Mol Sci. 2018 Sep 18;19(9):2825. doi: 10.3390/ijms19092825.
803 Impaired migration of trophoblast cells caused by simvastatin is associated with decreased membrane IGF-I receptor, MMP2 activity and HSP27 expression. Hum Reprod. 2007 Apr;22(4):1161-7. doi: 10.1093/humrep/del464. Epub 2006 Dec 11.
804 Quercetin Suppresses the Migration and Invasion in Human Colon Cancer Caco-2 Cells Through Regulating Toll-like Receptor 4/Nuclear Factor-kappa B Pathway. Pharmacogn Mag. 2016 May;12(Suppl 2):S237-44. doi: 10.4103/0973-1296.182154. Epub 2016 May 11.
805 Troglitazone but not conjugated linoleic acid reduces gene expression and activity of matrix-metalloproteinases-2 and -9 in PMA-differentiated THP-1 macrophages. J Nutr Biochem. 2008 Sep;19(9):594-603. doi: 10.1016/j.jnutbio.2007.08.003. Epub 2007 Dec 21.
806 Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation. Mol Cell Endocrinol. 2012 Jan 2;348(1):260-9. doi: 10.1016/j.mce.2011.09.002. Epub 2011 Sep 6.
807 Repetitive nonlethal oxidant injury to retinal pigment epithelium decreased extracellular matrix turnover in vitro and induced sub-RPE deposits in vivo. Invest Ophthalmol Vis Sci. 2006 Sep;47(9):4098-112. doi: 10.1167/iovs.05-1230.
808 Meclofenamate sodium is an inhibitor of both the 5-lipoxygenase and cyclooxygenase pathways of the arachidonic acid cascade in vitro. Prostaglandins Leukot Med. 1986 Aug;23(2-3):229-38.
809 Resveratrol prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity. Eur J Biochem. 1999 Oct 1;265(1):27-34.
810 Molecular actions of ebselen--an antiinflammatory antioxidant. Gen Pharmacol. 1995 Oct;26(6):1153-69.
811 Non-nutritional sweeteners effects on endothelial vascular function. Toxicol In Vitro. 2020 Feb;62:104694. doi: 10.1016/j.tiv.2019.104694. Epub 2019 Oct 23.
812 Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5591-4.
813 Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers. Nat Commun. 2018 Sep 26;9(1):3931.
814 Metronomic gemcitabine suppresses tumour growth, improves perfusion, and reduces hypoxia in human pancreatic ductal adenocarcinoma. Br J Cancer. 2010 Jun 29;103(1):52-60.
815 Levamisole induced apoptosis in cultured vascular endothelial cells. Br J Pharmacol. 2000 Dec;131(8):1577-83.
816 Tryptanthrin induces growth inhibition and neuronal differentiation in the human neuroblastoma LA-N-1 cells. Chem Biol Interact. 2013 Apr 25;203(2):512-21. doi: 10.1016/j.cbi.2013.03.001. Epub 2013 Mar 13.
817 Protective role of Ashwagandha leaf extract and its component withanone on scopolamine-induced changes in the brain and brain-derived cells. PLoS One. 2011;6(11):e27265. doi: 10.1371/journal.pone.0027265. Epub 2011 Nov 11.
818 Epigenetic silencing of novel tumor suppressors in malignant melanoma. Cancer Res. 2006 Dec 1;66(23):11187-93. doi: 10.1158/0008-5472.CAN-06-1274.
819 Arsenic metabolites affect expression of the neurofilament and tau genes: an in-vitro study into the mechanism of arsenic neurotoxicity. Toxicol In Vitro. 2007 Sep;21(6):1104-12. doi: 10.1016/j.tiv.2007.04.007. Epub 2007 Apr 27.
820 Analysis of estrogen agonism and antagonism of tamoxifen, raloxifene, and ICI182780 in endometrial cancer cells: a putative role for the epidermal growth factor receptor ligand amphiregulin. J Soc Gynecol Investig. 2005 Oct;12(7):e55-67.
821 Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. Surgery. 2005 Sep;138(3):415-21. doi: 10.1016/j.surg.2005.06.030.
822 Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo. J Invest Dermatol. 2006 Apr;126(4):732-9. doi: 10.1038/sj.jid.5700202.
823 Amphiregulin is a vitamin D3 target gene in squamous cell and breast carcinoma. Biochem Biophys Res Commun. 2001 Mar 9;281(4):1051-6. doi: 10.1006/bbrc.2001.4466.
824 Effects of retinoids on cancerous phenotype and apoptosis in organotypic cultures of ovarian carcinoma. J Natl Cancer Inst. 2001 Apr 4;93(7):516-25. doi: 10.1093/jnci/93.7.516.
825 Retinoic acid can induce markers of endocrine transdifferentiation in pancreatic ductal adenocarcinoma: preliminary observations from an in vitro cell line model. J Clin Pathol. 2006 Jun;59(6):603-10. doi: 10.1136/jcp.2005.032003. Epub 2006 Feb 10.
826 Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
827 Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J Nutr Biochem. 2007 Aug;18(8):541-52. doi: 10.1016/j.jnutbio.2006.11.002. Epub 2007 Feb 22.
828 Muc-1 core protein is expressed on multiple myeloma cells and is induced by dexamethasone. Blood. 1999 Feb 15;93(4):1287-98.
829 Gaseous nitrogen oxide promotes human lung cancer cell line A549 migration, invasion, and metastasis via iNOS-mediated MMP-2 production. Toxicol Sci. 2008 Dec;106(2):364-75. doi: 10.1093/toxsci/kfn195. Epub 2008 Sep 16.
830 Tetracaine downregulates matrix metalloproteinase activity and inhibits invasiveness of strongly metastatic MDA-MB-231 human breast cancer cells. Chem Biol Interact. 2023 Nov 1;385:110730. doi: 10.1016/j.cbi.2023.110730. Epub 2023 Oct 7.
831 The retinoid anticancer signal: mechanisms of target gene regulation. Br J Cancer. 2005 Aug 8;93(3):310-8. doi: 10.1038/sj.bjc.6602700.
832 Indomethacin and ibuprofen effect on IL-1ra production by mononuclear cells of preterm newborns and adults. Biol Neonate. 2002 Aug;82(2):73-7. doi: 10.1159/000063090.
833 Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
834 1,25-dihydroxyvitamin D3 stimulates activin A production to fine-tune osteoblast-induced mineralization. J Cell Physiol. 2013 Nov;228(11):2167-74. doi: 10.1002/jcp.24388.
835 Darinaparsin: solid tumor hypoxic cytotoxin and radiosensitizer. Clin Cancer Res. 2012 Jun 15;18(12):3366-76.
836 Heme oxygenase-1 and interleukin-11 are overexpressed in stress-induced premature senescence of human WI-38 fibroblasts induced by tert-butylhydroperoxide and ethanol. Biogerontology. 2007 Aug;8(4):409-22. doi: 10.1007/s10522-007-9084-8. Epub 2007 Feb 13.
837 Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class. Toxicol Lett. 2016 Jan 22;241:82-94.
838 Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes. Chem Biol Interact. 2016 Aug 5;255:31-44.
839 Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR. Yakugaku Zasshi. 2002 May;122(5):339-61.
840 Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor. Chem Res Toxicol. 2014 Feb 17;27(2):304-308.
841 Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin. J Biol Chem. 2004 Jul 9;279(28):29295-301. doi: 10.1074/jbc.M400580200. Epub 2004 Apr 28.
842 Identification of novel agonists by high-throughput screening and molecular modelling of human constitutive androstane receptor isoform 3. Arch Toxicol. 2019 Aug;93(8):2247-2264. doi: 10.1007/s00204-019-02495-6. Epub 2019 Jul 16.
843 Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor. Mol Pharmacol. 2005 Jun;67(6):1954-65.
844 Characterization of human cytochrome P450 induction by pesticides. Toxicology. 2012 Mar 29;294(1):17-26.
845 Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. Arch Biochem Biophys. 2005 Feb 1;434(1):75-85.
846 Pyrethroids: cytotoxicity and induction of CYP isoforms in human hepatocytes. Drug Metabol Drug Interact. 2008;23(3-4):211-36.
847 Ecto-5'-nucleotidase/CD73 inhibition by quercetin in the human U138MG glioma cell line. Biochim Biophys Acta. 2007 Sep;1770(9):1352-9.
848 Heparin binding epidermal growth factor-like growth factor reduces ethanol-induced apoptosis and differentiation in human embryonic stem cells. Growth Factors. 2009 Dec;27(6):362-9. doi: 10.3109/08977190903159953.
849 Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance. Hematology. 2007 Dec;12(6):511-7. doi: 10.1080/10245330701562535.
850 Thalidomide and Its Analogs Differentially Target Fibroblast Growth Factor Receptors: Thalidomide Suppresses FGFR Gene Expression while Pomalidomide Dampens FGFR2 Activity. Chem Res Toxicol. 2019 Apr 15;32(4):589-602. doi: 10.1021/acs.chemrestox.8b00286. Epub 2019 Mar 15.
851 Increased expression of fibroblast growth factor receptor 3 in CD34+ BCR-ABL+ cells from patients with chronic myeloid leukemia. Leukemia. 2003 Dec;17(12):2418-25. doi: 10.1038/sj.leu.2403152.
852 Acetaminophen selectively suppresses peripheral prostaglandin E2 release and increases COX-2 gene expression in a clinical model of acute inflammation. Pain. 2007 Jun;129(3):279-86.
853 Quercetin reduces oxidative damage induced by paraquat via modulating expression of antioxidant genes in A549 cells. J Appl Toxicol. 2013 Dec;33(12):1460-7. doi: 10.1002/jat.2812. Epub 2012 Sep 20.
854 The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model. Anesth Analg. 2008 Jan;106(1):321-7, table of contents.
855 Patterns of some extracellular matrix gene expression are similar in cells from cleft lip-palate patients and in human palatal fibroblasts exposed to diazepam in culture. Toxicology. 2009 Mar 4;257(1-2):10-6. doi: 10.1016/j.tox.2008.12.002. Epub 2008 Dec 9.
856 Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation. Mol Endocrinol. 2002 Jun;16(6):1243-56.
857 Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
858 Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615. doi: 10.1007/s00204-020-02970-5. Epub 2021 Jan 29.
859 Lack of uniform platelet activation in patients after ischemic stroke and choice of antiplatelet therapy. Thromb Res. 2004;113(3-4):197-204. doi: 10.1016/j.thromres.2004.03.002.
860 Design and synthesis of pyrimidinone and pyrimidinedione inhibitors of dipeptidyl peptidase IV. J Med Chem. 2011 Jan 27;54(2):510-24.
861 Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. Neurotoxicology. 2015 Sep;50:56-70.
862 Novel hydrazine derivatives as selective DPP-IV inhibitors: findings from virtual screening and validation through molecular dynamics simulations. J Mol Model. 2014 Apr;20(4):2118. doi: 10.1007/s00894-014-2118-7. Epub 2014 Apr 1.
863 Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
864 Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
865 A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
866 The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
867 Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
868 Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
869 Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer. 2006 Mar 15;118(6):1370-80. doi: 10.1002/ijc.21537.
870 Expression of CD30 mRNA, CD30L mRNA and a variant form of CD30 mRNA in restimulated peripheral blood mononuclear cells (PBMC) of patients with helminthic infections resembling a Th2 disease. Clin Exp Immunol. 1999 Jan;115(1):114-9. doi: 10.1046/j.1365-2249.1999.00774.x.
871 Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells. Arch Toxicol. 2018 Apr;92(4):1507-1524.
872 Identification of potential biomarkers of hepatitis B-induced acute liver failure using hepatic cells derived from human skin precursors. Toxicol In Vitro. 2015 Sep;29(6):1231-9. doi: 10.1016/j.tiv.2014.10.012. Epub 2014 Oct 24.
873 Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
874 Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
875 Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol. Chem Biol Interact. 2014 May 25;215:62-8.
876 Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors. Chem Biol Interact. 2004 Apr 15;147(3):331-40.
877 The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis. Antimicrob Agents Chemother. 2004 Sep;48(9):3272-8.
878 Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos. 2001 Jan;29(1):30-5.
879 Arsenic trioxide (As(2)O(3)) induced apoptosis and its mechanisms in a human esophageal squamous carcinoma cell line. Chin Med J (Engl). 2002 Feb;115(2):280-5.
880 The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
881 Synergistic antiproliferative effect of arsenic trioxide combined with bortezomib in HL60 cell line and primary blasts from patients affected by myeloproliferative disorders. Cancer Genet Cytogenet. 2010 Jun;199(2):110-20. doi: 10.1016/j.cancergencyto.2010.02.010.
882 Distinct genetic profile in peripheral blood mononuclear cells of psoriatic arthritis patients treated with methotrexate and TNF-inhibitors. Clin Rheumatol. 2014 Dec;33(12):1815-21. doi: 10.1007/s10067-014-2807-8. Epub 2014 Oct 24.
883 Gene expression profile changes in NB4 cells induced by arsenic trioxide. Acta Pharmacol Sin. 2003 Jul;24(7):646-50.
884 Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells. J Clin Endocrinol Metab. 2013 Mar;98(3):E455-62.
885 Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
886 Pravastatin inhibited the cholesterol synthesis in human hepatoma cell line Hep G2 less than simvastatin and lovastatin, which is reflected in the upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and squalene synthase. Biochem Pharmacol. 1993 Jun 9;45(11):2203-8.
887 Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells. Carcinogenesis. 2011 May;32(5):686-94. doi: 10.1093/carcin/bgr025. Epub 2011 Feb 10.
888 Contrasting effects of fluoroquinolone antibiotics on the expression of the collagenases, matrix metalloproteinases (MMP)-1 and -13, in human tendon-derived cells. Rheumatology (Oxford). 2005 Dec;44(12):1514-7. doi: 10.1093/rheumatology/kei087. Epub 2005 Sep 7.
889 Chloramphenicol causes mitochondrial stress, decreases ATP biosynthesis, induces matrix metalloproteinase-13 expression, and solid-tumor cell invasion. Toxicol Sci. 2010 Jul;116(1):140-50. doi: 10.1093/toxsci/kfq085. Epub 2010 Mar 25.
890 Matrix metalloproteinases of epithelial origin in facial sebum of patients with acne and their regulation by isotretinoin. J Invest Dermatol. 2005 Oct;125(4):673-84. doi: 10.1111/j.0022-202X.2005.23848.x.
891 Glucosamine promotes chondrogenic phenotype in both chondrocytes and mesenchymal stem cells and inhibits MMP-13 expression and matrix degradation. Osteoarthritis Cartilage. 2007 Jun;15(6):646-55. doi: 10.1016/j.joca.2007.01.014. Epub 2007 Mar 6.
892 Quercetin attenuates cell apoptosis of oxidant-stressed SK-N-MC cells while suppressing up-regulation of the defensive element, HIF-1alpha. Neuroscience. 2014 Sep 26;277:780-93.
893 Arsenic trioxide inhibits cell growth and induces apoptosis through inactivation of notch signaling pathway in breast cancer. Int J Mol Sci. 2012;13(8):9627-9641. doi: 10.3390/ijms13089627. Epub 2012 Aug 2.
894 Propranolol inhibits proliferation and invasion of hemangioma-derived endothelial cells by suppressing the DLL4/Notch1/Akt pathway. Chem Biol Interact. 2018 Oct 1;294:28-33. doi: 10.1016/j.cbi.2018.08.018. Epub 2018 Aug 18.
895 The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells. J Cell Biochem. 2009 Mar 1;106(4):682-92. doi: 10.1002/jcb.22065.
896 Mebendazole is a potent inhibitor to chemoresistant T cell acute lymphoblastic leukemia cells. Toxicol Appl Pharmacol. 2020 Jun 1;396:115001. doi: 10.1016/j.taap.2020.115001. Epub 2020 Apr 8.
897 Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
898 C/EBPalpha inactivation in FAK-overexpressed HL-60 cells impairs cell differentiation. Cell Signal. 2006 Jul;18(7):955-63. doi: 10.1016/j.cellsig.2005.08.014. Epub 2005 Oct 14.
899 Arsenic trioxide promotes senescence and regulates the balance of adipogenic and osteogenic differentiation in human mesenchymal stem cells. Acta Biochim Biophys Sin (Shanghai). 2011 Mar;43(3):204-9. doi: 10.1093/abbs/gmq130. Epub 2011 Jan 21.
900 Effects of nevirapine and efavirenz on human adipocyte differentiation, gene expression, and release of adipokines and cytokines. Antiviral Res. 2011 Aug;91(2):112-9. doi: 10.1016/j.antiviral.2011.04.018. Epub 2011 May 17.
901 Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 2011 Mar;13(3):267-79. doi: 10.1093/neuonc/noq195. Epub 2011 Feb 3.
902 Two distinct phases of virus-induced nuclear factor kappa B regulation enhance tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in virus-infected cells. J Biol Chem. 2003 May 16;278(20):18092-100. doi: 10.1074/jbc.M300265200. Epub 2003 Mar 13.
903 TNF-related apoptosis-inducing ligand cooperates with NSAIDs via activated Wnt signalling in (pre)malignant colon cells. J Pathol. 2011 Feb;223(3):378-89. doi: 10.1002/path.2797. Epub 2010 Oct 29.
904 Alterations in eotaxin, monocyte chemoattractant protein-4, interleukin-5, and interleukin-13 after systemic steroid treatment for nasal polyps. Otolaryngol Head Neck Surg. 2004 Nov;131(5):585-9. doi: 10.1016/j.otohns.2004.05.028.
905 Expression of PPARgamma in eosinophils and its functional role in survival and chemotaxis. Immunol Lett. 2003 Apr 3;86(2):183-9. doi: 10.1016/s0165-2478(03)00003-8.
906 Paradoxical Effect of Chloroquine Treatment in Enhancing Chikungunya Virus Infection. Viruses. 2018 May 17;10(5):268. doi: 10.3390/v10050268.
907 Tacrolimus decreases the expression of eotaxin, CCR3, RANTES and interleukin-5 in atopic dermatitis. Br J Dermatol. 2005 Jun;152(6):1173-81. doi: 10.1111/j.1365-2133.2005.06474.x.
908 Protein kinase CbetaII activation by 1-beta-D-arabinofuranosylcytosine is antagonistic to stimulation of apoptosis and Bcl-2alpha down-regulation. J Biol Chem. 1997 Sep 19;272(38):23481-4. doi: 10.1074/jbc.272.38.23481.
909 450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. Environ Health Perspect. 2012 Oct;120(10):1425-31. doi: 10.1289/ehp.1205412. Epub 2012 Jul 31.
910 Propranolol inhibits proliferation and induces apoptosis of hemangioma-derived endothelial cells via Akt pathway by down-regulating Ang-2 expression. Chem Biol Interact. 2020 Jan 25;316:108925. doi: 10.1016/j.cbi.2019.108925. Epub 2019 Dec 12.
911 Malathion induced cancer-linked gene expression in human lymphocytes. Environ Res. 2020 Mar;182:109131. doi: 10.1016/j.envres.2020.109131. Epub 2020 Jan 10.
912 Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
913 mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
914 Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia. Clin Cancer Res. 2017 Feb 1;23(3):789-803. doi: 10.1158/1078-0432.CCR-16-0226. Epub 2016 Aug 4.
915 Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
916 High-resolution analysis of 3p deletion in neuroblastoma and differential methylation of the SEMA3B tumor suppressor gene. Cancer Genet Cytogenet. 2007 Apr 15;174(2):100-10. doi: 10.1016/j.cancergencyto.2006.11.017.
917 Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse. PLoS One. 2006 Dec 27;1(1):e114. doi: 10.1371/journal.pone.0000114.
918 A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
919 Cannabidiol induces osteoblast differentiation via angiopoietin1 and p38 MAPK. Environ Toxicol. 2020 Dec;35(12):1318-1325. doi: 10.1002/tox.22996. Epub 2020 Jul 13.
920 Effects of methotrexate on vascular endothelial growth factor, angiopoietin 1, and angiopoietin 2 in nasal polyps. Am J Rhinol Allergy. 2011 Jul-Aug;25(4):e129-32. doi: 10.2500/ajra.2011.25.3618.
921 Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway. Blood. 2005 Feb 1;105(3):1214-21. doi: 10.1182/blood-2004-03-1182. Epub 2004 Sep 28.
922 Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
923 Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environ Health Perspect. 2008 Apr;116(4):524-31. doi: 10.1289/ehp.10861.
924 Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1) expression: role of chelatable iron. J Biol Chem. 2011 Dec 2;286(48):41413-41424. doi: 10.1074/jbc.M111.287052. Epub 2011 Oct 5.
925 Differential gene expression of sulindac-treated human breast epithelial cells. Int J Oncol. 2005 Dec;27(6):1727-36.
926 Hypermethylation of the nel-like 1 gene is a common and early event and is associated with poor prognosis in early-stage esophageal adenocarcinoma. Oncogene. 2007 Sep 20;26(43):6332-40. doi: 10.1038/sj.onc.1210461. Epub 2007 Apr 23.
927 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Pharmacogenomics J. 2014 Feb;14(1):35-40. doi: 10.1038/tpj.2013.3. Epub 2013 Feb 12.
928 Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions. Pharmacogenomics. 2012 Mar;13(4):399-405. doi: 10.2217/pgs.11.165.
929 Synergistic induction of the MUC4 mucin gene by interferon-gamma and retinoic acid in human pancreatic tumour cells involves a reprogramming of signalling pathways. Oncogene. 2005 Sep 8;24(40):6143-54. doi: 10.1038/sj.onc.1208756.
930 Promoter CpG methylation in cancer cells contributes to the regulation of MUC4. Br J Cancer. 2009 Jan 27;100(2):344-51. doi: 10.1038/sj.bjc.6604845. Epub 2009 Jan 6.
931 Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.
932 Diesel Exhaust Particles Enhance MUC4 Expression in NCI-H292 Cells and Nasal Epithelial Cells via the p38/CREB Pathway. Int Arch Allergy Immunol. 2016;171(3-4):209-216. doi: 10.1159/000453033. Epub 2017 Jan 4.
933 A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302. doi: 10.1371/journal.pone.0178302. eCollection 2017.
934 Effects of nickel treatment on H3K4 trimethylation and gene expression. PLoS One. 2011 Mar 24;6(3):e17728. doi: 10.1371/journal.pone.0017728.
935 Regulation of chromatin assembly and cell transformation by formaldehyde exposure in human cells. Environ Health Perspect. 2017 Sep 21;125(9):097019.
936 Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J Exp Med. 2009 Mar 16;206(3):535-48. doi: 10.1084/jem.20082293. Epub 2009 Mar 9.
937 Induction of heme oxygenase-1 by cobalt protoporphyrin enhances the antitumour effect of bortezomib in adult T-cell leukaemia cells. Br J Cancer. 2007 Oct 22;97(8):1099-105. doi: 10.1038/sj.bjc.6604003. Epub 2007 Sep 25.
938 Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition. Drug Metab Dispos. 2003 Apr;31(4):439-46.
939 Potential of pranlukast and zafirlukast in the inhibition of human liver cytochrome P450 enzymes. Xenobiotica. 2004 May;34(5):429-38.
940 The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes. Life Sci. 2006 Nov 25;79(26):2432-40.
941 Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78.
942 Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation. Pharmacogenetics. 1997 Jun;7(3):211-21.
943 Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes. Arch Biochem Biophys. 2003 Jan 1;409(1):32-44.
944 Differential inhibition of human CYP2C8 and molecular docking interactions elicited by sorafenib and its major N-oxide metabolite. Chem Biol Interact. 2021 Apr 1;338:109401. doi: 10.1016/j.cbi.2021.109401. Epub 2021 Feb 5.
945 Dabrafenib inhibits ABCG2 and cytochrome P450 isoenzymes; potential implications for combination anticancer therapy. Toxicol Appl Pharmacol. 2022 Jan 1;434:115797. doi: 10.1016/j.taap.2021.115797. Epub 2021 Nov 13.
946 Effect of ovarian steroids on gene expression profile in human uterine microvascular endothelial cells. Fertil Steril. 2009 Aug;92(2):709-21.
947 Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
948 The relative role of CYP3A4 and CYP3A5 in eplerenone metabolism. Toxicol Lett. 2019 Oct 15;315:9-13.
949 Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells. Toxicol Sci. 2006 Jul;92(1):51-60.
950 Mechanism-based inactivation of CYP3A by HIV protease inhibitors. J Pharmacol Exp Ther. 2005 Feb;312(2):583-91.
951 Studies of the toxicological potential of capsinoids, XIII: inhibitory effects of capsaicin and capsinoids on cytochrome P450 3A4 in human liver microsomes. Int J Toxicol. 2010 Mar;29(2 Suppl):22S-6S.
952 Investigation of the effects of axitinib on the pharmacokinetics of loperamide and its main metabolite N-demethylated loperamide in rats by UPLC-MS/MS. Chem Biol Interact. 2019 Sep 1;310:108744. doi: 10.1016/j.cbi.2019.108744. Epub 2019 Jul 9.
953 Contribution of CYP3A5 to hepatic and renal ifosfamide N-dechloroethylation. Drug Metab Dispos. 2005 Jul;33(7):1074-81. doi: 10.1124/dmd.104.002279. Epub 2005 Apr 8.
954 Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):86-96.
955 Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity. J Toxicol Sci. 2017;42(3):343-348.
956 Induction of hepatic CYP3A enzymes by pregnancy-related hormones: studies in human hepatocytes and hepatic cell lines. Drug Metab Dispos. 2013 Feb;41(2):281-90.
957 Human recombinant cytochrome P450 enzymes display distinct hydrogen peroxide generating activities during substrate independent NADPH oxidase reactions. Toxicol Sci. 2014 Oct;141(2):344-52. doi: 10.1093/toxsci/kfu133. Epub 2014 Jul 24.
958 Cytochrome P450 2D6 genotype and steady state plasma levels of risperidone and 9-hydroxyrisperidone. Psychopharmacology (Berl). 1999 Dec;147(3):300-5. doi: 10.1007/s002130051171.
959 Effect of penicillin-based antibiotics, amoxicillin, ampicillin, and piperacillin, on drug-metabolizing activities of human hepatic cytochromes P450. J Toxicol Sci. 2016 Feb;41(1):143-6.
960 Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Drug Metab Dispos. 2011 Nov;39(11):2049-56. doi: 10.1124/dmd.111.041384. Epub 2011 Aug 5.
961 Identification of human P450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its kinetic parameters and inhibition constants. Biol Pharm Bull. 2005 Feb;28(2):328-34.
962 Pharmacokinetics of desipramine HCl when administered with cinacalcet HCl. Eur J Clin Pharmacol. 2007 Feb;63(2):159-63.
963 Inhibition of cytochrome P4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test. Clin Pharmacol Ther. 2001 Oct;70(4):327-35.
964 Interaction of buprenorphine and its metabolite norbuprenorphine with cytochromes p450 in vitro. Drug Metab Dispos. 2003 Jun;31(6):768-72.