Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMODJ40)

Drug Name
Ethinyl Estradiol Drug Info
Synonyms
Aethinyloestradiolum; Aethinyoestradiol; Amenoron; Amenorone; Anovlar; Certostat; Cyclosa; Dicromil; Diprol; Dyloform; Ertonyl; Esteed; Estigyn; Estinyl; Estopherol; Estoral; Estorals; Ethidol; Ethinoral; Ethinylestradiolum; Ethinylestriol; Ethinyloestradiol; Ethynylestradiol; Ethynyloestradiol; Eticyclin; Eticyclol; Eticylol; Etinestrol; Etinestryl; Etinilestradiol; Etinilestradiolo; Etinoestryl; Etistradiol; Etivex; Feminone; Follicoral; Ginestrene; Inestra; Kolpolyn; Linoral; Lynoral; Menolyn; Microfollin; Novestrol; Oradiol; Orestralyn; Orestrayln; Palonyl; Perovex; Primogyn; Prosexol; Spanestrin; Ylestrol; Aethinyoestradiol [German]; Component of Demulen; Component of Oracon; Component of Ortrel; Diogyn E; Effik Brand of Ethinyl Estradiol; Estoral [Orion]; Ethinyl Estradiol Hemihydrate; Ethinyl Estradiol [USP]; Ethinyl Oestradiol Effik; Ethinylestradiol Jenapharm; Ethinyloestradiol [Steroidal oestrogens]; Ethynyl estradiol; Etinilestradiolo [DCIT]; Jenapharm Brand of Ethinyl Estradiol; Microfollin Forte; Organon Brand of Ethinyl Estradiol; PUBERTAL ETHINYL ESTRADIOL STUDY; Primogyn C; Primogyn M; Progynon C; Progynon M; Schering Brand of Ethinyl Estradiol; EE2; Ethinyl E2; Ethy 11; Diognat-E; Diogyn-E; EE(sub 2); Estinyl (TN); Eston-E; Estoral (Orion); Estoral (VAN); Estradiol, Ethinyl; Estradiol, Ethynyl; Ethinyl estradiol (USP); Ethinyl-Oestradiol Effik; Ethinyl-oestranol; Ethinylestradiolum [INN-Latin]; Ethynylestradiol, Ethinyl Estradiol; Etinilestradiol [INN-Spanish]; Hemihydrate, Ethinyl Estradiol; Jenapharm, Ethinylestradiol; Neo-Estrone; Nogest-S; OVULEN-21; OVULEN-28; Ortho-Cyclen; Chee-O-Gen; Chee-O-Genf; Ethinylestradiol (JP15/INN); Ethinylestradiol [INN:BAN:JAN]; Ethinyl Estradiol, (8 alpha)-Isomer; 17 alpha-Ethinylestradiol; 17 alpha-Ethynylestradiol; 17 alpha-Ethynyloestradiol; 17 alpha-ethinyestradiol; 17-Ethinyl-3,17-estradiol; 17-Ethinyl-3,17-oestradiol; 17-Ethinylestradiol; 17-Ethynylestradiol; 17-Ethynyloestradiol; 17-alpha-Ethinyl-17-beta-estradiol; 17-alpha-Ethynyl-17-beta-oestradiol; 17-alpha-Ethynylestradiol; 17-alpha-Ethynylestradiol-17-beta; 17-alpha-Ethynylestradiol-l7-beta; 17-alpha-Ethynyloestradiol-17-beta; 17-alpha-ethynyl estradiol; 17.alpha.-Ethinyl-17.beta.-estradiol; 17.alpha.-Ethinylestradiol; 17.alpha.-Ethynyl-17.beta.-oestradiol; 17.alpha.-Ethynylestradiol; 17.alpha.-Ethynyloestradiol; 17a-Ethynylestradiol; 17alpha-Ethinyl estradiol; 17alpha-Ethinylestradiol; 17alpha-Ethinylestradiol-17beta; 17alpha-Ethynylestradiol; 17alpha-Ethynyloestradiol; 17alpha-Ethynyloestradiol-17beta
Indication
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Approved [1]
Female hypogonadism GA30.6 Approved [2]
Hot flushes GA30 Approved [1]
Obsolete atrophic vulva Approved [1]
Therapeutic Class
Estrogens
Cross-matching ID
PubChem CID
5991
ChEBI ID
CHEBI:4903
CAS Number
CAS 57-63-6
TTD Drug ID
DMODJ40
VARIDT Drug ID
DR00103
INTEDE Drug ID
DR0656

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Estrogen receptor (ESR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [12]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [13]
Estrone DM5T6US Acne vulgaris ED80 Approved [13]
Estradiol Valerate DM8MC6O Hormone replacement therapy 8E01 Approved [14]
Estradiol Acetate DM07U2A Hormone replacement therapy 8E01 Approved [14]
Estradiol Cypionate DM27Z5T Hormone replacement therapy 8E01 Approved [14]
Raloxifene DMDKF3M Osteoporosis FB83.0 Approved [15]
Ospemifene DMC4GEI Dyspareunia GA12 Approved [16]
Toremifene DMQYUWG Breast cancer 2C60-2C65 Approved [17]
Mestranol DMG3F94 Contraception QA21 Approved [18]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [19]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [20]
Methotrexate DM2TEOL Anterior urethra cancer Approved [21]
Folic Acid DMEMBJC Colorectal carcinoma Approved [22]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [21]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [21]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [23]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [21]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [24]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [25]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [26]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [27]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [28]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [31]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [32]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [33]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [27]
Verapamil DMA7PEW Angina pectoris BA40 Approved [34]
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [90]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [91]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [92]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [93]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [94]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [94]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [95]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [96]
Capsaicin DMGMF6V Back pain ME84.Z Approved [97]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [98]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [35]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [36]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [37]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [38]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [39]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [41]
Metronidazole DMTIVEN Abscess Approved [7]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [42]
Ethanol DMDRQZU Chronic pain MG30 Approved [43]
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Drug(s) Metabolized By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [44]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [45]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [46]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [47]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [48]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [49]
Estrone DM5T6US Acne vulgaris ED80 Approved [50]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [51]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [52]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [53]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [80]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [81]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [82]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [83]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [84]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [85]
Ethacrynic acid DM60QMR Edema MG29 Approved [86]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [87]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [88]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [89]
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Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [54]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [55]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [55]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [56]
Verapamil DMA7PEW Angina pectoris BA40 Approved [57]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [58]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [59]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [55]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [60]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [61]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [9]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [75]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [9]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [75]
Sulfinpyrazone DMEV954 Gout FA25 Approved [76]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [9]
Zafirlukast DMHNQOG Asthma CA23 Approved [9]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [77]
Dabrafenib DMX6OE3 Melanoma 2C30 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [79]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [62]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [63]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [64]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [56]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [65]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [56]
Verapamil DMA7PEW Angina pectoris BA40 Approved [66]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [67]
Estrone DM5T6US Acne vulgaris ED80 Approved [68]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [69]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [91]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [99]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [94]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [93]
Capsaicin DMGMF6V Back pain ME84.Z Approved [100]
Zafirlukast DMHNQOG Asthma CA23 Approved [101]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [94]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [102]
Fluconazole DMOWZ6B Cryptococcal meningitis Approved [93]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [94]
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Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [70]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [62]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [71]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [72]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [56]
Verapamil DMA7PEW Angina pectoris BA40 Approved [73]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [69]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [74]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [61]
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Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [91]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [103]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [93]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [104]
Capsaicin DMGMF6V Back pain ME84.Z Approved [100]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [94]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [105]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [94]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [103]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [106]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [107]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [108]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [109]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [110]
Cepharanthine DM9Y5JB N. A. N. A. Approved [111]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [112]
Clozapine DMFC71L Schizophrenia 6A20 Approved [113]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [114]
Trifluoperazine DMKBYWI Anxiety Approved [115]
Olanzapine DMPFN6Y Bipolar depression Approved [113]
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Drug(s) Affected By Sulfotransferase 1E1 (SULT1E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [116]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [116]
Methotrexate DM2TEOL Anterior urethra cancer Approved [117]
Estrone DM5T6US Acne vulgaris ED80 Approved [118]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [116]
Dienestrol DMBSXI0 Atrophic vaginitis GA30.2 Approved [118]
Ethanol DMDRQZU Chronic pain MG30 Approved [119]
Folic Acid DMEMBJC Colorectal carcinoma Approved [120]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [121]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [122]
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Drug(s) Affected By Gamma-aminobutyric acid receptor subunit pi (GABRP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [124]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [126]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [128]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [129]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [130]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [131]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
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Drug(s) Affected By Ectoderm-neural cortex protein 1 (ENC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [134]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [136]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [137]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [140]
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Drug(s) Affected By Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [143]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [144]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
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Drug(s) Affected By Neuropilin-1 (NRP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [150]
Methotrexate DM2TEOL Anterior urethra cancer Approved [151]
Quercetin DM3NC4M Obesity 5B81 Approved [152]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [153]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [156]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
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Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [159]
Diazepam DM08E9O Alcohol withdrawal Approved [159]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Selenium DM25CGV N. A. N. A. Approved [160]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [159]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [159]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [159]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [159]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [159]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [159]
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Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Fluoxetine DM3PD2C Bipolar depression Approved [162]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [163]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [164]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [165]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [163]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [166]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [168]
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Drug(s) Affected By Krueppel-like factor 4 (KLF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [169]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [171]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [172]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [169]
Testosterone DM7HUNW Hot flushes GA30 Approved [173]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [156]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [174]
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Drug(s) Affected By Band 4.1-like protein 2 (EPB41L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [176]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [177]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [179]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [180]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [181]
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Drug(s) Affected By Tetraspanin-1 (TSPAN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [124]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [182]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [183]
OTX-015 DMI8RG1 Acute myeloid leukaemia 2A60 Phase 1/2 [184]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [131]
Mivebresib DMCPF90 Acute myeloid leukaemia 2A60 Phase 1 [184]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [185]
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Drug(s) Affected By Microfibrillar-associated protein 3-like (MFAP3L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [165]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [186]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [187]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [155]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [185]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [188]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Short-chain dehydrogenase/reductase 3 (DHRS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [143]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [189]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [156]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [190]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dysferlin (DYSF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [167]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Amiloride DMRTSGP Congestive heart failure BD10 Approved [192]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [193]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [194]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [196]
Urethane DM7NSI0 N. A. N. A. Phase 4 [197]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Gamma-butyrobetaine dioxygenase (BBOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [198]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [200]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [198]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [201]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [202]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [203]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nebulette (NEBL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [155]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [204]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Arsenic DMTL2Y1 N. A. N. A. Approved [205]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [206]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [155]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [207]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent DNA helicase Q5 (RECQL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [160]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [186]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [208]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [209]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [209]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [185]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [210]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sorbin and SH3 domain-containing protein 2 (SORBS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Testosterone DM7HUNW Hot flushes GA30 Approved [211]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [179]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [193]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [139]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [212]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine protease 23 (PRSS23)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Estrone DM5T6US Acne vulgaris ED80 Approved [214]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [167]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [216]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADH dehydrogenase 1 beta subcomplex subunit 6 (NDUFB6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [217]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [208]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [218]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [202]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [219]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [220]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Fenretinide DMRD5SP Macular degeneration 9B78.3 Phase 3 [221]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rap guanine nucleotide exchange factor 3 (RAPGEF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [222]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [223]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [194]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [196]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [183]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [224]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [185]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [225]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Secretoglobin family 1D member 2 (SCGB1D2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [226]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [203]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [227]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [228]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [229]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [126]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [230]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldehyde dehydrogenase 1A1 (ALDH1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [231]
Methotrexate DM2TEOL Anterior urethra cancer Approved [232]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [233]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [176]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [234]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [235]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [236]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Carbonic anhydrase 2 (CA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetazolamide DM1AF5U Absence epilepsy Approved [237]
Epinephrine DM3KJBC Acute asthma CA23 Approved [238]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [176]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [239]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [240]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [156]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [241]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [226]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [242]
Verapamil DMA7PEW Angina pectoris BA40 Approved [243]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [244]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [243]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [245]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [246]
Methotrexate DM2TEOL Anterior urethra cancer Approved [247]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [248]
Quercetin DM3NC4M Obesity 5B81 Approved [249]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [250]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [244]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [245]
Gefitinib DM15F0X Colon adenocarcinoma Approved [251]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [177]
Selenium DM25CGV N. A. N. A. Approved [252]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [253]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [254]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [255]
Methotrexate DM2TEOL Anterior urethra cancer Approved [256]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protransforming growth factor alpha (TGFA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [150]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [150]
Methotrexate DM2TEOL Anterior urethra cancer Approved [257]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [258]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [259]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [156]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By N-myc proto-oncogene protein (MYCN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [260]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [261]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [262]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [263]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [264]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [266]
Menthol DMG2KW7 Back pain ME84.Z Approved [267]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [137]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Paclitaxel DMLB81S Breast carcinoma Approved [268]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [141]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [269]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alkaline phosphatase, placental type (ALPP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [106]
Paricalcitol DMYBV3G Hyperparathyroidism 5A51 Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [270]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [271]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [272]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Isoproterenol DMK7MEY Atrioventricular block Approved [273]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [274]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [220]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-2(V) chain (COL5A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [165]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [275]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Testosterone enanthate DMB6871 N. A. N. A. Approved [276]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ethanol DMDRQZU Chronic pain MG30 Approved [277]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [278]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [141]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Progesterone receptor (PGR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [279]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [280]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [281]
Estrone DM5T6US Acne vulgaris ED80 Approved [282]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [283]
Testosterone DM7HUNW Hot flushes GA30 Approved [173]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [284]
Goserelin DMAT8CG Breast cancer 2C60-2C65 Approved [285]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [286]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thrombospondin-1 (THBS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [150]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Methotrexate DM2TEOL Anterior urethra cancer Approved [256]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [287]
Quercetin DM3NC4M Obesity 5B81 Approved [288]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [289]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [290]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [289]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [166]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [160]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [291]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [153]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [292]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [293]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [294]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [293]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [168]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-6 receptor subunit alpha (IL6R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [295]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [296]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Testosterone enanthate DMB6871 N. A. N. A. Approved [276]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [297]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [298]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [299]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Matrilysin (MMP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [151]
Quercetin DM3NC4M Obesity 5B81 Approved [300]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [301]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [124]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [302]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [303]
Clozapine DMFC71L Schizophrenia 6A20 Approved [304]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [305]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stromelysin-2 (MMP10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [139]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [306]
Methotrexate DM2TEOL Anterior urethra cancer Approved [290]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [287]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [289]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [290]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [289]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Haloperidol DM96SE0 Delirium Approved [307]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinol-binding protein 1 (RBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [308]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [309]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [190]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [180]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [310]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tropomyosin alpha-1 chain (TPM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [270]
Etretinate DM2CZFA Keratosis ED56 Approved [311]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Testosterone DM7HUNW Hot flushes GA30 Approved [211]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [312]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [297]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [278]
Bortezomib DMNO38U Leukemia Approved [313]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon alpha-inducible protein 6 (IFI6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [314]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [315]
Gefitinib DM15F0X Colon adenocarcinoma Approved [316]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Selenium DM25CGV N. A. N. A. Approved [160]
Methotrexate DM2TEOL Anterior urethra cancer Approved [290]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [163]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [290]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [275]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alkaline phosphatase, germ cell type (ALPG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [180]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [317]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [318]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [180]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [319]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [320]
Lithium chloride DMHYLQ2 Discovery agent N.A. Investigative [321]
Hydroxyestradiol DMJXQME N. A. N. A. Investigative [317]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [322]
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Drug(s) Affected By Creatine kinase B-type (CKB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [150]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Selenium DM25CGV N. A. N. A. Approved [160]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [289]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [289]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [271]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [323]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
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Drug(s) Affected By Insulin-like growth factor-binding protein 3 (IGFBP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Selenium DM25CGV N. A. N. A. Approved [324]
Methotrexate DM2TEOL Anterior urethra cancer Approved [325]
Quercetin DM3NC4M Obesity 5B81 Approved [326]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [153]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [289]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [189]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [327]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [328]
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Drug(s) Affected By Early growth response protein 1 (EGR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [169]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [329]
Methotrexate DM2TEOL Anterior urethra cancer Approved [257]
Quercetin DM3NC4M Obesity 5B81 Approved [330]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [85]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [331]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [309]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [332]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [226]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [87]
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Drug(s) Affected By Endothelin-2 (EDN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [143]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [275]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [333]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [334]
Arsenic DMTL2Y1 N. A. N. A. Approved [335]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [203]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [139]
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Drug(s) Affected By Collagen alpha-1(V) chain (COL5A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [165]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [336]
Testosterone enanthate DMB6871 N. A. N. A. Approved [276]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [337]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [278]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [338]
Arsenic DMTL2Y1 N. A. N. A. Approved [205]
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Drug(s) Affected By Fibroblast growth factor receptor 2 (FGFR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diazepam DM08E9O Alcohol withdrawal Approved [339]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [340]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [177]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [341]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [341]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [167]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
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Drug(s) Affected By Galanin peptides (GAL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [342]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [342]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [165]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [343]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [342]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [167]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibroblast growth factor receptor 3 (FGFR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [165]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [275]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [341]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [341]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [344]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By cAMP-dependent protein kinase catalytic subunit beta (PRKACB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [143]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [294]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Testosterone enanthate DMB6871 N. A. N. A. Approved [276]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [294]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [313]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [345]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [346]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [347]
Quercetin DM3NC4M Obesity 5B81 Approved [348]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [85]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [331]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [289]
Bupivacaine DM4PRFC Anaesthesia 9A78.6 Approved [349]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [289]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor-binding protein 5 (IGFBP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [150]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [329]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [153]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [350]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [165]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [327]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [343]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ethanol DMDRQZU Chronic pain MG30 Approved [351]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCN family member 2 (CCN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [306]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [150]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [290]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [171]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [275]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [169]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor HIVEP2 (HIVEP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [156]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Testosterone enanthate DMB6871 N. A. N. A. Approved [276]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [352]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [278]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [353]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium- and chloride-dependent taurine transporter (SLC6A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [168]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [168]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [354]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [179]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [180]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [355]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [356]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [357]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [358]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [347]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [359]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [360]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [150]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [361]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [362]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Activin receptor type-1B (ACVR1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [208]
Ethanol DMDRQZU Chronic pain MG30 Approved [351]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [201]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [345]
Arsenic DMTL2Y1 N. A. N. A. Approved [363]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [193]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [364]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [345]
Urethane DM7NSI0 N. A. N. A. Phase 4 [197]
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Drug(s) Affected By Collagen alpha-1(XV) chain (COL15A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [365]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [208]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [278]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [366]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [367]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [336]
Methotrexate DM2TEOL Anterior urethra cancer Approved [368]
Paclitaxel DMLB81S Breast carcinoma Approved [368]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Replication factor C subunit 3 (RFC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [369]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [153]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [370]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [167]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [354]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Exosome RNA helicase MTR4 (MTREX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [226]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [371]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [193]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [372]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [373]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [126]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [374]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G protein-activated inward rectifier potassium channel 1 (KCNJ3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [106]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [106]
Haloperidol DM96SE0 Delirium Approved [106]
Pimozide DMW83TP Schizophrenia 6A20 Approved [106]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [375]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [376]
Propranolol DM79NTF Angina pectoris BA40 Approved [377]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [194]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [196]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinol-binding protein 2 (RBP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [378]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
Milchsaure DM462BT Pruritus EC90 Investigative [379]
Drug(s) Affected By LIM domain kinase 2 (LIMK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Testosterone enanthate DMB6871 N. A. N. A. Approved [276]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [353]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [269]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Topotecan DMP6G8T Central nervous system neoplasm Approved [318]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ADP-ribosylation factor 3 (ARF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [380]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Arsenic DMTL2Y1 N. A. N. A. Approved [205]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [193]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Paclitaxel DMLB81S Breast carcinoma Approved [318]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [381]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [160]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [185]
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Drug(s) Affected By Transforming growth factor beta-2 proprotein (TGFB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [382]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [135]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [383]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [384]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [385]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [156]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphoserine phosphatase (PSPH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [386]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Testosterone enanthate DMB6871 N. A. N. A. Approved [276]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [387]
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Drug(s) Affected By Protein jagged-1 (JAG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Methotrexate DM2TEOL Anterior urethra cancer Approved [325]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [163]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [388]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [155]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [389]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [354]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 4-aminobutyrate aminotransferase, mitochondrial (ABAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [156]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [79]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [278]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
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Drug(s) Affected By Low-density lipoprotein receptor-related protein 2 (LRP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [390]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [391]
Methotrexate DM2TEOL Anterior urethra cancer Approved [257]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [391]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [155]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [208]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [214]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [246]
Selenium DM25CGV N. A. N. A. Approved [160]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [370]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [292]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [165]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [200]
Estrone DM5T6US Acne vulgaris ED80 Approved [214]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclic AMP-responsive element-binding protein 5 (CREB5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [392]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [177]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [393]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [394]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [179]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [204]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor SOX-4 (SOX4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [160]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [395]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [275]
Testosterone DM7HUNW Hot flushes GA30 Approved [211]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [156]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Testosterone enanthate DMB6871 N. A. N. A. Approved [276]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amino acid transporter heavy chain SLC3A1 (SLC3A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [396]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [397]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [193]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [398]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [398]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [399]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [364]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [183]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cadherin-18 (CDH18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [400]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [155]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [155]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [155]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [213]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [297]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calcyphosin (CAPS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [352]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [194]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [220]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [185]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Dp-2 (TFDP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [143]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [165]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [401]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Menthol DMG2KW7 Back pain ME84.Z Approved [267]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [387]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [353]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [338]
Arsenic DMTL2Y1 N. A. N. A. Approved [335]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [167]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [354]
Roflumilast DMPGHY8 Asthma CA23 Approved [402]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Arsenic DMTL2Y1 N. A. N. A. Approved [403]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Next to BRCA1 gene 1 protein (NBR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Methotrexate DM2TEOL Anterior urethra cancer Approved [256]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Testosterone DM7HUNW Hot flushes GA30 Approved [211]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [313]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [352]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [181]
Arsenic DMTL2Y1 N. A. N. A. Approved [404]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pericentriolar material 1 protein (PCM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [242]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [392]
Selenium DM25CGV N. A. N. A. Approved [160]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [137]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [405]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [297]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [126]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neutral amino acid transporter B(0) (SLC1A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [134]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [168]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [168]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [168]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [134]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [168]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [134]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adiponectin (ADIPOQ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [406]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [406]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [407]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [408]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [406]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [409]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [410]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [406]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [411]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [412]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 5 (DUSP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [306]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [413]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [414]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [275]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [168]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [156]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein Dok-7 (DOK7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [122]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [220]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [220]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [185]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [220]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [415]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein GREB1 (GREB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [150]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [416]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [417]
Testosterone DM7HUNW Hot flushes GA30 Approved [211]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [167]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [416]
Nandrolone DMFWKG1 Osteoporosis FB83.0 Approved [418]
Mestranol DMG3F94 Contraception QA21 Approved [416]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Piercer of microtubule wall 1 protein (PIERCE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [208]
Urethane DM7NSI0 N. A. N. A. Phase 4 [197]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [185]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Retrotransposon Gag-like protein 5 (RTL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [208]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [196]
Urethane DM7NSI0 N. A. N. A. Phase 4 [197]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [131]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [419]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [185]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [278]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein phosphatase 1J (PPM1J)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [160]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [420]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [203]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [220]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [208]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [196]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [155]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [220]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Immediate early response gene 5-like protein (IER5L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [226]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [352]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [278]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [179]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [220]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [421]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [364]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Disabled homolog 2-interacting protein (DAB2IP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [210]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [137]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [156]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Chlorothiazide DMLHESP Chronic heart failure BD1Z Approved [422]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [185]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Muscleblind-like protein 2 (MBNL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [137]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Testosterone enanthate DMB6871 N. A. N. A. Approved [276]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [405]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Anoctamin-1 (ANO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Folic Acid DMEMBJC Colorectal carcinoma Approved [120]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [180]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Nimodipine DMQ0RKZ Cerebral vasospasm BA85.Z Approved [423]
Arsenic DMTL2Y1 N. A. N. A. Approved [424]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [220]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proline-rich membrane anchor 1 (PRIMA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [167]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [297]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [364]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [196]
Chlorothiazide DMLHESP Chronic heart failure BD1Z Approved [425]
Urethane DM7NSI0 N. A. N. A. Phase 4 [197]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [183]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prolyl 3-hydroxylase 2 (P3H2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Ethanol DMDRQZU Chronic pain MG30 Approved [351]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [278]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Arsenic DMTL2Y1 N. A. N. A. Approved [426]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase TRIM22 (TRIM22)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [134]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [189]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [126]
Ethanol DMDRQZU Chronic pain MG30 Approved [427]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [313]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier family 25 member 45 (SLC25A45)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Folic Acid DMEMBJC Colorectal carcinoma Approved [120]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [193]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [428]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [229]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [185]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By PACRG-like protein (PACRGL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [429]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [185]
GALLICACID DM6Y3A0 Discovery agent N.A. Investigative [430]
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Drug(s) Affected By N-acetylaspartate synthetase (NAT8L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [220]
Urethane DM7NSI0 N. A. N. A. Phase 4 [197]
Fenfluramine DM0762O Dravet syndrome 8A61.11 Phase 3 [431]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [220]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [432]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [155]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinoic acid-induced protein 3 (GPRC5A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Methotrexate DM2TEOL Anterior urethra cancer Approved [325]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [275]
Testosterone DM7HUNW Hot flushes GA30 Approved [211]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [186]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Two pore channel protein 2 (TPCN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [126]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Arsenic DMTL2Y1 N. A. N. A. Approved [205]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [155]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [433]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [126]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By LIM domain only protein 3 (LMO3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [365]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [278]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [434]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [196]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [155]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [435]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DEP domain-containing mTOR-interacting protein (DEPTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [436]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [354]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [278]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [275]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [167]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [437]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [196]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [185]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [438]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Complexin-3 (CPLX3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [393]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [194]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
Milchsaure DM462BT Pruritus EC90 Investigative [379]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Histone acetyltransferase KAT2B (KAT2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [151]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [439]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [226]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [389]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [440]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein kinase C-binding protein NELL1 (NELL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [441]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [442]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [196]
Chlorothiazide DMLHESP Chronic heart failure BD1Z Approved [422]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [443]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [183]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By LIM/homeobox protein Lhx4 (LHX4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [167]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [194]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [155]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase MIB2 (MIB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [389]
Arsenic DMTL2Y1 N. A. N. A. Approved [205]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [442]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [185]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [213]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [126]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dedicator of cytokinesis protein 10 (DOCK10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Quercetin DM3NC4M Obesity 5B81 Approved [444]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Galactose mutarotase (GALM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [163]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [124]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [141]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [193]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endoplasmic reticulum resident protein 27 (ERP27)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [79]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [179]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [180]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hedgehog-interacting protein (HHIP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [324]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [156]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [445]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [208]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [446]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [447]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TSC22 domain family protein 3 (TSC22D3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [448]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [392]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [370]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [169]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [156]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [208]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [126]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [222]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [313]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neurturin (NRTN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [376]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [180]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [449]
Arsenic DMTL2Y1 N. A. N. A. Approved [363]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [139]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [450]
Urethane DM7NSI0 N. A. N. A. Phase 4 [197]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras-like protein family member 11B (RASL11B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [167]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [204]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [451]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [451]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [155]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitochondrial ribosome-associated GTPase 1 (MTG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [452]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [143]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [208]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [143]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [185]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [453]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Melanophilin (MLPH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [321]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [180]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [220]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [212]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [454]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RNA-binding protein 24 (RBM24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [124]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [179]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [180]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [204]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Keratin-associated protein 2-1 (KRTAP2-1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [455]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [456]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [457]
Drug(s) Affected By Keratin, type I cytoskeletal 23 (KRT23)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [275]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [124]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Folic Acid DMEMBJC Colorectal carcinoma Approved [120]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [458]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [141]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [156]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [203]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [220]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [220]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [459]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [153]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [226]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
Isoproterenol DMK7MEY Atrioventricular block Approved [460]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [442]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Plexin-A4 (PLXNA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [120]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [278]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [364]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [208]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [183]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [185]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [188]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Palmdelphin (PALMD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [275]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [193]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [194]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription and mRNA export factor ENY2 (ENY2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [242]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [364]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [208]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [456]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [155]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal peptide, CUB and EGF-like domain-containing protein 2 (SCUBE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [376]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [167]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Arsenic DMTL2Y1 N. A. N. A. Approved [205]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [434]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [208]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [155]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 26B1 (CYP26B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [263]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [156]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [394]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [461]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [451]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Arsenic DMTL2Y1 N. A. N. A. Approved [205]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [187]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Olfactomedin-like protein 3 (OLFML3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [226]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [124]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ethanol DMDRQZU Chronic pain MG30 Approved [427]
Paclitaxel DMLB81S Breast carcinoma Approved [462]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [180]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [203]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytokine-inducible SH2-containing protein (CISH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Methotrexate DM2TEOL Anterior urethra cancer Approved [257]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [352]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [220]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [196]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [220]
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Drug(s) Affected By ATPase family AAA domain-containing protein 3A (ATAD3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [144]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Clozapine DMFC71L Schizophrenia 6A20 Approved [307]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [387]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [194]
Urethane DM7NSI0 N. A. N. A. Phase 4 [197]
GSK2110183 DMZHB37 leukaemia 2A60-2B33 Phase 2 [463]
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Drug(s) Affected By Kv channel-interacting protein 1 (KCNIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [442]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [196]
AMEP DMFELMQ Melanoma 2C30 Phase 1 [464]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
Glyphosate DM0AFY7 Malaria 1F40-1F45 Investigative [464]
3R14S-OCHRATOXIN A DM2KEW6 Discovery agent N.A. Investigative [465]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [225]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [466]
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Drug(s) Affected By Denticleless protein homolog (DTL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [467]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [167]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [126]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [352]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [354]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxisomal sarcosine oxidase (PIPOX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [468]
Ethanol DMDRQZU Chronic pain MG30 Approved [427]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Arsenic DMTL2Y1 N. A. N. A. Approved [205]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [203]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [270]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [469]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [124]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [278]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [180]
Arsenic DMTL2Y1 N. A. N. A. Approved [470]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [193]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [471]
Fructose DM43AN2 Vomiting MD90 Approved [472]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [473]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [474]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [226]
Ketotifen DM74XKS Allergic conjunctivitis 9A60.02 Approved [475]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [476]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [476]
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Drug(s) Affected By Dickkopf-related protein 3 (DKK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [226]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Folic Acid DMEMBJC Colorectal carcinoma Approved [477]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [451]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein NDRG2 (NDRG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Testosterone enanthate DMB6871 N. A. N. A. Approved [276]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [190]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [278]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho family-interacting cell polarization regulator 2 (RIPOR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [478]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [204]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [208]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [479]
Coprexa DMA0WEK Neurological disorder 6B60 Phase 3 [480]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [155]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor HES-2 (HES2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [167]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [297]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [180]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [220]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [180]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [481]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tolloid-like protein 2 (TLL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [376]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [442]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [220]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [482]
Urethane DM7NSI0 N. A. N. A. Phase 4 [197]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [155]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [220]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [131]
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Drug(s) Affected By Metallothionein-2 (MT2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [483]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [306]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [329]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [484]
Quercetin DM3NC4M Obesity 5B81 Approved [485]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [85]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [294]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [137]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [343]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [168]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aryl hydrocarbon receptor (AHR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [150]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [486]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [487]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [488]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [489]
Quercetin DM3NC4M Obesity 5B81 Approved [490]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [491]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [492]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [493]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [208]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Arsenic DMTL2Y1 N. A. N. A. Approved [205]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [494]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [318]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [318]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [318]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [318]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Putative hydrolase DDAH2 (DDAH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [160]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Iron Dextran DM5OY70 Iron-deficiency anemia 3A00 Approved [495]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [352]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [496]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin beta-3 (ITGB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [497]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [498]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [499]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [302]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [500]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [501]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [203]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [228]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [502]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Small integral membrane protein 6 (SMIM6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [196]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [183]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [503]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [169]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [244]
Gefitinib DM15F0X Colon adenocarcinoma Approved [504]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [329]
Selenium DM25CGV N. A. N. A. Approved [160]
Etretinate DM2CZFA Keratosis ED56 Approved [311]
Methotrexate DM2TEOL Anterior urethra cancer Approved [256]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [85]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin beta-6 (ITGB6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [246]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [167]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Paclitaxel DMLB81S Breast carcinoma Approved [462]
Bortezomib DMNO38U Leukemia Approved [313]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [505]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [506]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Deoxyribonuclease-1 (DNASE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [256]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [289]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [289]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Menthol DMG2KW7 Back pain ME84.Z Approved [267]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [201]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [206]
Urethane DM7NSI0 N. A. N. A. Phase 4 [197]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [183]
GSK2110183 DMZHB37 leukaemia 2A60-2B33 Phase 2 [463]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G0/G1 switch protein 2 (G0S2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Selenium DM25CGV N. A. N. A. Approved [507]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [234]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [275]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [156]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [270]
Selenium DM25CGV N. A. N. A. Approved [252]
Methotrexate DM2TEOL Anterior urethra cancer Approved [151]
Quercetin DM3NC4M Obesity 5B81 Approved [508]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [509]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [510]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [511]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [512]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein MOX-1 (MEOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [513]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [514]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [514]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [514]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [376]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [514]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [514]
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [514]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Diacylglycerol kinase epsilon (DGKE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Epanova DMHEAGL Hypertriglyceridemia 5C80.1 Approved [515]
Bortezomib DMNO38U Leukemia Approved [313]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [220]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [364]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [220]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [131]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [224]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [185]
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Drug(s) Affected By Cadherin-6 (CDH6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [393]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [352]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [442]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [516]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [155]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phospholipid-transporting ATPase ID (ATP8B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [206]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [434]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [517]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [183]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [453]
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Drug(s) Affected By Transgelin (TAGLN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [518]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [519]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [518]
Methotrexate DM2TEOL Anterior urethra cancer Approved [520]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [518]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Fluoxetine DM3PD2C Bipolar depression Approved [518]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [521]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [519]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Programmed cell death protein 4 (PDCD4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [522]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [523]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [522]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [294]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [226]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [524]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [275]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [522]
Testosterone DM7HUNW Hot flushes GA30 Approved [211]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sclerostin domain-containing protein 1 (SOSTDC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [376]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [366]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [364]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [155]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [183]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [131]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transmembrane protein 64 (TMEM64)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [278]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [525]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [155]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [155]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Echinoderm microtubule-associated protein-like 6 (EML6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [392]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [203]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [364]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [364]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [183]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [131]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [126]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [297]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By PX domain-containing protein kinase-like protein (PXK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [226]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [278]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [204]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [206]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [220]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [155]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [494]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein limb expression 1 homolog (LIX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [365]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [394]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [352]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [196]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [155]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [183]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Uncharacterized protein FAM241A (FAM241A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [420]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [79]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [190]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [278]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RalBP1-associated Eps domain-containing protein 2 (REPS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [211]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [190]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [338]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [196]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [517]
Urethane DM7NSI0 N. A. N. A. Phase 4 [197]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [183]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [419]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Syntaxin-binding protein 6 (STXBP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [376]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [275]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Heroin diacetylmorphine DMDBWHY Neurological disorder 6B60 Approved [526]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [220]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [196]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [527]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By POC1 centriolar protein homolog B (POC1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Bortezomib DMNO38U Leukemia Approved [313]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [183]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [185]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [528]
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Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [396]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [275]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [420]
Folic Acid DMEMBJC Colorectal carcinoma Approved [120]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [352]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [442]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [155]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pleckstrin homology-like domain family A member 1 (PHLDA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [306]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [226]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [275]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Testosterone enanthate DMB6871 N. A. N. A. Approved [276]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxidasin homolog (PXDN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [177]
Testosterone enanthate DMB6871 N. A. N. A. Approved [276]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [122]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Arsenic DMTL2Y1 N. A. N. A. Approved [529]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [530]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Secreted frizzled-related protein 3 (FRZB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [531]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [531]
Testosterone enanthate DMB6871 N. A. N. A. Approved [276]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [394]
Folic Acid DMEMBJC Colorectal carcinoma Approved [120]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [352]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [278]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA endonuclease RBBP8 (RBBP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [214]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Estrone DM5T6US Acne vulgaris ED80 Approved [214]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [167]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [364]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [126]
Mestranol DMG3F94 Contraception QA21 Approved [214]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transmembrane protease serine 4 (TMPRSS4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [531]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [531]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [394]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [187]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [183]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
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Drug(s) Affected By Cdc42 effector protein 3 (CDC42EP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [163]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [532]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [167]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [204]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [353]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [193]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Teneurin-1 (TENM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [256]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [376]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [517]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [338]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [203]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [517]
Urethane DM7NSI0 N. A. N. A. Phase 4 [197]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [183]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RNA polymerase II elongation factor ELL2 (ELL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [306]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [165]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [420]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [517]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [313]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mothers against decapentaplegic homolog 6 (SMAD6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [257]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [226]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [156]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [533]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [130]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [534]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [534]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [535]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [536]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [537]
Etidronic acid DM1XHYJ Bone Paget disease Approved [534]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [534]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [534]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [538]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [539]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAS guanyl-releasing protein 1 (RASGRP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Indomethacin DMSC4A7 Bursitis Approved [516]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [338]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [442]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [540]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [541]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [542]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [542]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [121]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [541]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [542]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [543]
Gefitinib DM15F0X Colon adenocarcinoma Approved [541]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [544]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [541]
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Drug(s) Affected By Cytochrome c oxidase subunit 3 (COX3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [217]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [532]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [468]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [545]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [546]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [546]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [547]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [548]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prothrombin (F2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [549]
Methotrexate DM2TEOL Anterior urethra cancer Approved [256]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [550]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [551]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [552]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [553]
Phytonadione DM8HDOL Bleeding disorder GA20-GA21 Approved [554]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Testosterone enanthate DMB6871 N. A. N. A. Approved [555]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [556]
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Drug(s) Affected By Plasminogen (PLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [557]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [558]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [193]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [139]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [364]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [559]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [560]
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Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [561]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [562]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [563]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [564]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [565]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [566]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [567]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [568]
Epinephrine DM3KJBC Acute asthma CA23 Approved [569]
Chlorthalidone DM4DMBT Edema MG29 Approved [570]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP synthase subunit a (ATP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [571]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [217]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [572]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [468]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [219]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [573]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Urethane DM7NSI0 N. A. N. A. Phase 4 [197]
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Drug(s) Affected By Antithrombin-III (SERPINC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Prednisone DM2HG4X Acute asthma CA23 Approved [574]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Testosterone enanthate DMB6871 N. A. N. A. Approved [555]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Aminocaproic Acid DMFGND4 Bleeding disorder GA20-GA21 Approved [574]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [575]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [576]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Angiotensinogen (AGT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [435]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [577]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [564]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [578]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [579]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [567]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [580]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [581]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Low-density lipoprotein receptor (LDLR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [582]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [329]
Desogestrel DM27U4Y Contraception QA21 Approved [582]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [583]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [584]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [135]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [163]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [165]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Follitropin subunit beta (FSHB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [585]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [586]
Goserelin DMAT8CG Breast cancer 2C60-2C65 Approved [587]
Folic Acid DMEMBJC Colorectal carcinoma Approved [120]
Cetrorelix DMFD9Q6 Ovarian stimulation LB45.1 Approved [588]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [589]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [590]
Risperidone DMN6DXL Bipolar I disorder Approved [591]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Naltrexone DMUL45H Alcohol dependence 6C40.2 Approved [592]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lutropin subunit beta (LHB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [593]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [594]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [595]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [596]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [585]
Alprazolam DMC7XDN Anxiety Approved [597]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Norethindrone acetate DMDGCQP N. A. N. A. Approved [594]
Metoclopramide DMFA5MY Nausea MD90 Approved [596]
Cetrorelix DMFD9Q6 Ovarian stimulation LB45.1 Approved [588]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Somatotropin (GH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [598]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [599]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [600]
Cyproheptadine DM92AH3 Allergic rhinitis CA08.0 Approved [601]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Sodium oxybate DMBOV5P Narcolepsy 7A20 Approved [602]
Ethanol DMDRQZU Chronic pain MG30 Approved [598]
Connexyn DMF29Q5 Attention deficit hyperactivity disorder 6A05.Z Approved [603]
Gamma Hydroxybutyric Acid DMGBKVD Narcolepsy 7A20 Approved [604]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [605]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor II (IGF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dantrolene DM1D8XY Hyperthermia MG26 Approved [606]
Quercetin DM3NC4M Obesity 5B81 Approved [326]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [289]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [386]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [607]
Testosterone DM7HUNW Hot flushes GA30 Approved [608]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [297]
Folic Acid DMEMBJC Colorectal carcinoma Approved [609]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [354]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-reactive protein (CRP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [106]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [610]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [611]
Quercetin DM3NC4M Obesity 5B81 Approved [612]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [135]
Acalabrutinib DM7GCVW leukaemia 2A60-2B33 Approved [613]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [614]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [615]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [616]
Testosterone DM7HUNW Hot flushes GA30 Approved [211]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Estrogen receptor (ESR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [617]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [618]
Gefitinib DM15F0X Colon adenocarcinoma Approved [619]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [620]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [621]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [622]
Quercetin DM3NC4M Obesity 5B81 Approved [623]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [624]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [620]
Estrone DM5T6US Acne vulgaris ED80 Approved [625]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Trefoil factor 1 (TFF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [626]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [418]
Quercetin DM3NC4M Obesity 5B81 Approved [627]
Estrone DM5T6US Acne vulgaris ED80 Approved [628]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [417]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [418]
Testosterone DM7HUNW Hot flushes GA30 Approved [629]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [124]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [284]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histidine-rich glycoprotein (HRG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [79]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [630]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [631]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [632]
Olanzapine DMPFN6Y Bipolar depression Approved [633]
Arsenic DMTL2Y1 N. A. N. A. Approved [363]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [203]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sex hormone-binding globulin (SHBG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [634]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Fructose DM43AN2 Vomiting MD90 Approved [635]
Oxcarbazepine DM5PU6O Epilepsy 8A60-8A68 Approved [636]
Estrone DM5T6US Acne vulgaris ED80 Approved [637]
Testosterone DM7HUNW Hot flushes GA30 Approved [638]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Dienestrol DMBSXI0 Atrophic vaginitis GA30.2 Approved [637]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [637]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [637]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [639]
Methotrexate DM2TEOL Anterior urethra cancer Approved [256]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [640]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [641]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [642]
Paclitaxel DMLB81S Breast carcinoma Approved [643]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [644]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [260]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [645]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [646]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor I (IGF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dantrolene DM1D8XY Hyperthermia MG26 Approved [606]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [647]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [648]
Quercetin DM3NC4M Obesity 5B81 Approved [326]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [289]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [289]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [226]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [649]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Testosterone DM7HUNW Hot flushes GA30 Approved [328]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endothelin-1 (EDN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [650]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [651]
Methotrexate DM2TEOL Anterior urethra cancer Approved [151]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [652]
Quercetin DM3NC4M Obesity 5B81 Approved [653]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [143]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [654]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [655]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [656]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [657]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [658]
Fructose DM43AN2 Vomiting MD90 Approved [106]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [659]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [660]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [244]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [661]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [392]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [662]
Methotrexate DM2TEOL Anterior urethra cancer Approved [663]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thrombomodulin (THBD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [278]
Methotrexate DM2TEOL Anterior urethra cancer Approved [257]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [550]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [376]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [124]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [664]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Indomethacin DMSC4A7 Bursitis Approved [665]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Vitamin K-dependent protein S (PROS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Desogestrel DM27U4Y Contraception QA21 Approved [666]
Methotrexate DM2TEOL Anterior urethra cancer Approved [256]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [165]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Testosterone enanthate DMB6871 N. A. N. A. Approved [555]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Folic Acid DMEMBJC Colorectal carcinoma Approved [120]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Sp1 (SP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [667]
Quercetin DM3NC4M Obesity 5B81 Approved [668]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [669]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [670]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [671]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [667]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [672]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [673]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Asparagine synthetase (ASNS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [169]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [518]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [459]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [518]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [291]
Methotrexate DM2TEOL Anterior urethra cancer Approved [290]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [674]
Fluoxetine DM3PD2C Bipolar depression Approved [518]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [153]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Coagulation factor VII (F7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Mestranol DMG3F94 Contraception QA21 Approved [675]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [79]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [676]
Morphine DMRMS0L Advanced cancer 2A00-2F9Z Approved [677]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [678]
Cenestin DMXQS7K Menopause symptom GA30.0 Approved [679]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Osteopontin (SPP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [680]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [150]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [595]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [681]
Quercetin DM3NC4M Obesity 5B81 Approved [682]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [683]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [143]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [189]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [200]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Chromogranin-A (CHGA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [394]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [201]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [684]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [442]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [228]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [685]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [155]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase pim-1 (PIM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [686]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [687]
Methotrexate DM2TEOL Anterior urethra cancer Approved [257]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [143]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [552]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [226]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [275]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [688]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Keratin, type II cytoskeletal 5 (KRT5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [689]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [289]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [289]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [690]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [124]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [365]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [289]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [691]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Beta-1,4-galactosyltransferase 1 (B4GALT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [692]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [156]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [126]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [278]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [693]
Estriol DMOEM2I Hormone deficiency 5A61.1 Approved [693]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [193]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fos-related antigen 1 (FOSL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [136]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [552]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [234]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [694]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [275]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [343]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Gap junction alpha-1 protein (GJA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [695]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [177]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [696]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Folic Acid DMEMBJC Colorectal carcinoma Approved [520]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [140]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [695]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [697]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [698]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor-binding protein 2 (IGFBP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Selenium DM25CGV N. A. N. A. Approved [160]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [143]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [696]
Testosterone DM7HUNW Hot flushes GA30 Approved [328]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [420]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [169]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [329]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [291]
Methotrexate DM2TEOL Anterior urethra cancer Approved [699]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [287]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [484]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [294]
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Drug(s) Affected By Myelin and lymphocyte protein (MAL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [531]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [531]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [208]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [632]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [700]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [220]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [318]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [183]
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Drug(s) Affected By Insulin-like growth factor-binding protein 4 (IGFBP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [245]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Selenium DM25CGV N. A. N. A. Approved [160]
Methotrexate DM2TEOL Anterior urethra cancer Approved [257]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [163]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [165]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [327]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [701]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [702]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [703]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [704]
Paclitaxel DMLB81S Breast carcinoma Approved [705]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [706]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [707]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [106]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [314]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [708]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [709]
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Drug(s) Affected By Insulin-like growth factor-binding protein complex acid labile subunit (IGFALS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [135]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Menthol DMG2KW7 Back pain ME84.Z Approved [267]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [201]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [710]
Cenestin DMXQS7K Menopause symptom GA30.0 Approved [710]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [196]
Urethane DM7NSI0 N. A. N. A. Phase 4 [197]
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Drug(s) Affected By ETS translocation variant 5 (ETV5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [210]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [531]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [370]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [353]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [193]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [187]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [711]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Radiation-inducible immediate-early gene IEX-1 (IER3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [306]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [246]
Selenium DM25CGV N. A. N. A. Approved [507]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [153]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [143]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [293]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [165]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [275]
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Drug(s) Affected By Solute carrier organic anion transporter family member 1A2 (SLCO1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trospium chloride DM32XZT Discovery agent N.A. Approved [712]
Saquinavir DMG814N Human immunodeficiency virus infection 1C62 Approved [713]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [714]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [715]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [156]
Testosterone enanthate DMB6871 N. A. N. A. Approved [276]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [297]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [716]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [364]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [450]
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Drug(s) Affected By Stromal cell-derived factor 1 (CXCL12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [513]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [214]
Methotrexate DM2TEOL Anterior urethra cancer Approved [256]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [717]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [165]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Estrone DM5T6US Acne vulgaris ED80 Approved [214]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [388]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [718]
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Drug(s) Affected By NADP-dependent malic enzyme (ME1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [719]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [329]
Selenium DM25CGV N. A. N. A. Approved [160]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [720]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [165]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [395]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [168]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [168]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [721]
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Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [719]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [722]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [723]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [720]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [724]
Quercetin DM3NC4M Obesity 5B81 Approved [725]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [153]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [726]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [727]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cysteine--tRNA ligase, cytoplasmic (CARS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [270]
Methotrexate DM2TEOL Anterior urethra cancer Approved [257]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [293]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [728]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [168]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [168]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [293]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [297]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine--tRNA ligase, cytoplasmic (SARS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Haloperidol DM96SE0 Delirium Approved [307]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [168]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [168]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Benzatropine DMF7EXL Parkinsonian disorder Approved [307]
Clozapine DMFC71L Schizophrenia 6A20 Approved [307]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCAAT/enhancer-binding protein delta (CEBPD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [163]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [376]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [532]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [167]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [186]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Inhibin beta E chain (INHBE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [518]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [519]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [518]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [518]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Fluoxetine DM3PD2C Bipolar depression Approved [518]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [79]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [674]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [518]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [260]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [729]
Methotrexate DM2TEOL Anterior urethra cancer Approved [256]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [730]
Quercetin DM3NC4M Obesity 5B81 Approved [330]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [731]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [732]
Testosterone DM7HUNW Hot flushes GA30 Approved [211]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transformer-2 protein homolog beta (TRA2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [137]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [166]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [364]
Clozapine DMFC71L Schizophrenia 6A20 Approved [307]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Arsenic DMTL2Y1 N. A. N. A. Approved [205]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [224]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Small ribosomal subunit protein RACK1 (RACK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [733]
Quercetin DM3NC4M Obesity 5B81 Approved [734]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [735]
Testosterone DM7HUNW Hot flushes GA30 Approved [735]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Benzatropine DMF7EXL Parkinsonian disorder Approved [307]
Clozapine DMFC71L Schizophrenia 6A20 Approved [307]
Nandrolone DMFWKG1 Osteoporosis FB83.0 Approved [736]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [314]
Flucytosine DM13VTW Cryptococcal meningitis Approved [737]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [737]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [738]
Methotrexate DM2TEOL Anterior urethra cancer Approved [151]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [739]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [640]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [294]
Amifostine DM5FL14 Mucositis CA00 Approved [740]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Schlafen family member 5 (SLFN5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [376]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [741]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [201]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [193]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [169]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [742]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [743]
Methotrexate DM2TEOL Anterior urethra cancer Approved [744]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [745]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [408]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [331]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [746]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [294]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Four and a half LIM domains protein 2 (FHL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [291]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Estrone DM5T6US Acne vulgaris ED80 Approved [214]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [376]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [167]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
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Drug(s) Affected By Hepatic sodium/bile acid cotransporter (SLC10A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [720]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [747]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [748]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [136]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [749]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [750]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [751]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [538]
Quercetin DM3NC4M Obesity 5B81 Approved [752]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [258]
Artemether DM48QOT Malaria 1F40-1F45 Approved [753]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [754]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [136]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [492]
Estrone DM5T6US Acne vulgaris ED80 Approved [755]
Leflunomide DMR8ONJ Arthritis FA20 Approved [756]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
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Drug(s) Affected By Advanced glycosylation end product-specific receptor (AGER)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [757]
Testosterone DM7HUNW Hot flushes GA30 Approved [211]
TRIENTINE DMD2WPG Inborn error of metabolism 5C50-5C59 Approved [758]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [759]
Mebendazole DMO14SG Ascariasis 1F62 Approved [760]
Estriol DMOEM2I Hormone deficiency 5A61.1 Approved [11]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [759]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [206]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [11]
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Drug(s) Affected By Erythroferrone (ERFE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [761]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [155]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [229]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [225]
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Drug(s) Affected By FYVE, RhoGEF and PH domain-containing protein 3 (FGD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [306]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [156]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [155]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [353]
Arsenic DMTL2Y1 N. A. N. A. Approved [470]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [194]
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Drug(s) Affected By Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (PDZK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [214]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [165]
Estrone DM5T6US Acne vulgaris ED80 Approved [762]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [364]
Mestranol DMG3F94 Contraception QA21 Approved [214]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [693]
Estriol DMOEM2I Hormone deficiency 5A61.1 Approved [693]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
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Drug(s) Affected By Early estrogen-induced gene 1 protein (EEIG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ethanol DMDRQZU Chronic pain MG30 Approved [427]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [79]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [693]
Estriol DMOEM2I Hormone deficiency 5A61.1 Approved [693]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [763]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Very-long-chain (HACD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Testosterone DM7HUNW Hot flushes GA30 Approved [211]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [124]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [278]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Arsenic DMTL2Y1 N. A. N. A. Approved [205]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [194]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retrotransposon-derived protein PEG10 (PEG10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [764]
Testosterone DM7HUNW Hot flushes GA30 Approved [211]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [146]
Ethanol DMDRQZU Chronic pain MG30 Approved [765]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ly6/PLAUR domain-containing protein 1 (LYPD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [451]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [203]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [155]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Scavenger receptor class B member 1 (SCARB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [766]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [767]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [768]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [769]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [770]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [771]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [468]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stonin-2 (STON2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [257]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Trifluoperazine DMKBYWI Anxiety Approved [772]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [203]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [453]
Urethane DM7NSI0 N. A. N. A. Phase 4 [197]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [185]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein NDRG1 (NDRG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [647]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [773]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [774]
Quercetin DM3NC4M Obesity 5B81 Approved [288]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [153]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [163]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [420]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [352]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Estrogen receptor beta (ESR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [150]
Gefitinib DM15F0X Colon adenocarcinoma Approved [775]
Quercetin DM3NC4M Obesity 5B81 Approved [776]
Estrone DM5T6US Acne vulgaris ED80 Approved [777]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [778]
Testosterone DM7HUNW Hot flushes GA30 Approved [779]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [780]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [781]
Mestranol DMG3F94 Contraception QA21 Approved [782]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [783]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lopinavir DMITQS0 Human immunodeficiency virus infection 1C62 Approved [784]
Sulfinpyrazone DMEV954 Gout FA25 Approved [785]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [786]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [787]
Methotrexate DM2TEOL Anterior urethra cancer Approved [788]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [789]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [750]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [790]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [791]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [193]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor protein p53-inducible nuclear protein 1 (TP53INP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Methotrexate DM2TEOL Anterior urethra cancer Approved [151]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [792]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [793]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [168]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [168]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [168]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 8 (MED8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [165]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Testosterone enanthate DMB6871 N. A. N. A. Approved [276]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [372]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [225]
CH-223191 DMMJZYC Solid tumour/cancer 2A00-2F9Z Investigative [794]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Bile acid receptor (NR1H4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [742]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [795]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [750]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [796]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [136]
Nisoldipine DM7ISKJ Hypertension BA00-BA04 Approved [795]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [750]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [797]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tribbles homolog 3 (TRIB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [169]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [293]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [294]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [200]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [293]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [275]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [798]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G-protein coupled estrogen receptor 1 (GPER1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [524]
Quercetin DM3NC4M Obesity 5B81 Approved [799]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [800]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [524]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [79]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [147]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [625]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Captopril DM458UM Chronic heart failure BD1Z Approved [801]
Diazepam DM08E9O Alcohol withdrawal Approved [159]
Dantrolene DM1D8XY Hyperthermia MG26 Approved [159]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [159]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [159]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [159]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [159]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [159]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [159]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [159]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein associated with UVRAG as autophagy enhancer (RUBCNL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [124]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [533]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [364]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [213]
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Drug(s) Affected By Tetratricopeptide repeat protein 12 (TTC12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [226]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [148]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Arsenic DMTL2Y1 N. A. N. A. Approved [205]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [187]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [447]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [142]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [185]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier family 40 member 1 (SLC40A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [292]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [301]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Folic Acid DMEMBJC Colorectal carcinoma Approved [802]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [803]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Matrix-remodeling-associated protein 5 (MXRA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [213]
Methotrexate DM2TEOL Anterior urethra cancer Approved [290]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [153]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [124]
Testosterone enanthate DMB6871 N. A. N. A. Approved [276]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Folic Acid DMEMBJC Colorectal carcinoma Approved [120]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [122]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [290]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal-induced proliferation-associated 1-like protein 2 (SIPA1L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [167]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [168]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [168]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [804]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [168]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [278]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kelch-like protein 14 (KLHL14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Panobinostat DM58WKG Chronic graft versus host disease Approved [155]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [376]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [156]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [126]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor MafF (MAFF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [719]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [150]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [805]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [135]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [153]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [165]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [136]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [719]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [361]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [392]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [361]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [361]
Methotrexate DM2TEOL Anterior urethra cancer Approved [290]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [806]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Fluoxetine DM3PD2C Bipolar depression Approved [293]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [361]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proton-coupled zinc antiporter SLC30A1 (SLC30A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [306]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [291]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [271]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [292]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [165]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [294]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [376]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [156]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By SET-binding protein (SETBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [160]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [215]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [126]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [278]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [195]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [183]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [160]
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Drug(s) Affected By Sulfotransferase 2A1 (SULT2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Methotrexate DM2TEOL Anterior urethra cancer Approved [257]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [289]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [289]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [136]
Leflunomide DMR8ONJ Arthritis FA20 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [807]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [468]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [203]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [808]
Minoxidil DMA2Z4F Alopecia ED70 Approved [809]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [810]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [809]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [116]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [270]
Methotrexate DM2TEOL Anterior urethra cancer Approved [117]
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [791]
Methotrexate DM2TEOL Anterior urethra cancer Approved [811]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [812]
Calcipotriol DM03CP7 Psoriasis EA90 Approved [813]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [719]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [245]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Prednisone DM2HG4X Acute asthma CA23 Approved [814]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [724]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [815]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sulfotransferase 1B1 (SULT1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [810]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [203]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [816]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [817]
Arsenic DMTL2Y1 N. A. N. A. Approved [403]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [818]
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [819]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [820]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sulfotransferase 1A3 (SULT1A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [203]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [821]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ethanol DMDRQZU Chronic pain MG30 Approved [119]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [201]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [632]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [822]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [810]
Epinephrine DM3KJBC Acute asthma CA23 Approved [809]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [809]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [823]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [823]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [823]
Capsaicin DMGMF6V Back pain ME84.Z Approved [100]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [824]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [105]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [825]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [826]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [827]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [106]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibroblast growth factor 4 (FGF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [551]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [338]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [828]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [208]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [829]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [155]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [155]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [297]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [104]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [830]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [831]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [832]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [833]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [834]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [835]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [836]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [837]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [838]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [90]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [91]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [96]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [96]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [839]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [715]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [840]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [841]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen receptor (ESR) TTZAYWL ESR1_HUMAN Agonist [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [5]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [6]
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Substrate [6]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [7]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [8]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [9]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
4-aminobutyrate aminotransferase, mitochondrial (ABAT) OTXAGR7J GABT_HUMAN Gene/Protein Processing [10]
A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) OTV3Q0DS ATS9_HUMAN Gene/Protein Processing [10]
Activin receptor type-1B (ACVR1B) OT778HIQ ACV1B_HUMAN Gene/Protein Processing [10]
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Gene/Protein Processing [10]
ADP-ribosylation factor 3 (ARF3) OTYYQX85 ARF3_HUMAN Gene/Protein Processing [10]
Advanced glycosylation end product-specific receptor (AGER) OTPY0IH7 RAGE_HUMAN Gene/Protein Processing [11]
Aldehyde dehydrogenase 1A1 (ALDH1A1) OTCUWZKB AL1A1_HUMAN Gene/Protein Processing [10]
Alkaline phosphatase, germ cell type (ALPG) OTCIM29R PPBN_HUMAN Gene/Protein Processing [10]
Alkaline phosphatase, placental type (ALPP) OTZU4G9W PPB1_HUMAN Gene/Protein Processing [10]
Amino acid transporter heavy chain SLC3A1 (SLC3A1) OT56V01A SLC31_HUMAN Gene/Protein Processing [10]

References

1 Ethinyl estradiol FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7071).
3 17alpha-Ethinylestradiol hinders nucleotide excision repair in zebrafish liver cells. Aquat Toxicol. 2009 Dec 13;95(4):273-8.
4 P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul;21(7):1284-93.
5 Rifampicin, a keystone inducer of drug metabolism: from Herbert Remmer's pioneering ideas to modern concepts. Drug Metab Rev. 2004 Oct;36(3-4):497-509.
6 The involvement of CYP3A4 and CYP2C9 in the metabolism of 17 alpha-ethinylestradiol. Drug Metab Dispos. 2004 Nov;32(11):1209-12.
7 Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8.
8 The effect of ethinyloestradiol and levonorgestrel on the CYP2C19-mediated metabolism of omeprazole in healthy female subjects. Br J Clin Pharmacol. 2003 Aug;56(2):232-7.
9 Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78.
10 The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
11 Differential effect of estrogen receptor alpha and beta agonists on the receptor for advanced glycation end product expression in human microvascular endothelial cells. Biochim Biophys Acta. 2005 Sep 30;1745(3):300-9. doi: 10.1016/j.bbamcr.2005.03.012. Epub 2005 Apr 12.
12 Modulators of vascular sex hormone receptors and their effects in estrogen-deficiency states associated with menopause. Recent Pat Cardiovasc Drug Discov. 2008 Nov;3(3):165-86.
13 Reprint of Are all estrogens the same Maturitas. 2008 Sep-Oct;61(1-2):195-201.
14 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
15 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 620).
16 Clinical pipeline report, company report or official report of Shionogi (2011).
17 Effect of selective estrogen receptor modulators on cell proliferation and estrogen receptor activities in normal human prostate stromal and epithe... Prostate Cancer Prostatic Dis. 2009;12(4):375-81.
18 Short-term effects of environmentally relevant concentrations of EDC mixtures on Mytilus galloprovincialis digestive gland. Aquat Toxicol. 2008 May 30;87(4):272-9.
19 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
20 MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
21 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
22 Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
23 Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
24 Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
25 Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
26 Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer. 2007 Mar 1;109(5):957-65.
27 Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47.
28 Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.
29 Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone. Drug Metab Dispos. 2013 Feb;41(2):263-9.
30 Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
31 Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates. Br J Pharmacol. 2012 Apr;165(8):2787-98.
32 Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos. 2007 Apr;28(3):151-6.
33 The metabolism of zidovudine by human liver microsomes in vitro: formation of 3'-amino-3'-deoxythymidine. Biochem Pharmacol. 1994 Jul 19;48(2):267-76.
34 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
35 Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites. Cancer Res. 2009 Mar 1;69(5):1892-900.
36 Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A1 enzymes. Life Sci. 2010 Aug 14;87(7-8):261-8.
37 Effect of UDP-glucuronosyltransferase (UGT) 1A polymorphism (rs8330 and rs10929303) on glucuronidation status of acetaminophen. Dose Response. 2017 Sep 11;15(3):1559325817723731.
38 UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for etoposide glucuronidation in human liver and intestinal microsomes: structural characterization of phenolic and alcoholic glucuronides of etoposide and estimation of enzyme kinetics. Drug Metab Dispos. 2007 Mar;35(3):371-80.
39 Interindividual variability in pharmacokinetics of generic nucleoside reverse transcriptase inhibitors in TB/HIV-coinfected Ghanaian patients: UGT2B7*1c is associated with faster zidovudine clearance and glucuronidation. J Clin Pharmacol. 2009 Sep;49(9):1079-90.
40 Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10. Drug Metab Dispos. 2009 Jan;37(1):229-36.
41 Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid. Drug Metab Dispos. 2006 Sep;34(9):1632-9.
42 Substrate-dependent modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1) by propofol in recombinant human UGT1A1 and human liver microsomes. Basic Clin Pharmacol Toxicol. 2007 Sep;101(3):211-4.
43 Identification and preliminary characterization of UDP-glucuronosyltransferases catalyzing formation of ethyl glucuronide. Anal Bioanal Chem. 2014 Apr;406(9-10):2325-32.
44 Allelic variants of human cytochrome P450 1A1 (CYP1A1): effect of T461N and I462V substitutions on steroid hydroxylase specificity. Pharmacogenetics. 2000 Aug;10(6):519-30.
45 Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos. 2002 Aug;30(8):869-74.
46 Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA. Metabolism. 2007 Jul;56(7):887-94.
47 Preferred orientations in the binding of 4'-hydroxyacetanilide (acetaminophen) to cytochrome P450 1A1 and 2B1 isoforms as determined by 13C- and 15N-NMR relaxation studies. J Med Chem. 1994 Mar 18;37(6):860-7.
48 The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. Sci Total Environ. 2007 Aug 1;381(1-3):38-46.
49 Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. Biochemistry. 1999 Oct 26;38(43):14264-70.
50 A common CYP1B1 polymorphism is associated with 2-OHE1/16-OHE1 urinary estrone ratio. Clin Chem Lab Med. 2005;43(7):702-6.
51 Cytochromes P450 in crustacea. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Nov;121(1-3):157-72.
52 Disruption of endogenous regulator homeostasis underlies the mechanism of rat CYP1A1 mRNA induction by metyrapone. Biochem J. 1998 Apr 1;331 ( Pt 1):273-81.
53 Pharmacogenomics in drug-metabolizing enzymes catalyzing anticancer drugs for personalized cancer chemotherapy. Curr Drug Metab. 2007 Aug;8(6):554-62.
54 Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63.
55 Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241.
56 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
57 Differential expression and function of CYP2C isoforms in human intestine and liver. Pharmacogenetics. 2003 Sep;13(9):565-75.
58 Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants. Biochemistry. 2004 Dec 14;43(49):15379-92.
59 Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study. Cancer Chemother Pharmacol. 2011 Nov;68(5):1111-8.
60 PharmGKB summary: mycophenolic acid pathway. Pharmacogenet Genomics. 2014 Jan;24(1):73-9.
61 Possible involvement of multiple human cytochrome P450 isoforms in the liver metabolism of propofol. Br J Anaesth. 1998 Jun;80(6):788-95.
62 Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9.
63 Tamoxifen inhibits cytochrome P450 2C9 activity in breast cancer patients. J Chemother. 2006 Aug;18(4):421-4.
64 Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98.
65 Drug-drug interactions with imatinib: an observational study. Medicine (Baltimore). 2016 Oct;95(40):e5076.
66 Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A. Drug Metab Dispos. 2000 Feb;28(2):125-30.
67 New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126.
68 A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis. Breast Cancer Res Treat. 2003 Dec;82(3):191-7.
69 A mechanistic approach to antiepileptic drug interactions. Ann Pharmacother. 1998 May;32(5):554-63.
70 High-dose rabeprazole/amoxicillin therapy as the second-line regimen after failure to eradicate H. pylori by triple therapy with the usual doses of a proton pump inhibitor, clarithromycin and amoxicillin. Hepatogastroenterology. 2003 Nov-Dec;50(54):2274-8.
71 Cytochrome P450 pharmacogenetics and cancer. Oncogene. 2006 Mar 13;25(11):1679-91.
72 CYP2C19*17 is associated with decreased breast cancer risk. Breast Cancer Res Treat. 2009 May;115(2):391-6.
73 Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol. 1995 Dec;353(1):116-21.
74 Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33.
75 Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation. Pharmacogenetics. 1997 Jun;7(3):211-21.
76 Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes. Arch Biochem Biophys. 2003 Jan 1;409(1):32-44.
77 Differential inhibition of human CYP2C8 and molecular docking interactions elicited by sorafenib and its major N-oxide metabolite. Chem Biol Interact. 2021 Apr 1;338:109401. doi: 10.1016/j.cbi.2021.109401. Epub 2021 Feb 5.
78 Dabrafenib inhibits ABCG2 and cytochrome P450 isoenzymes; potential implications for combination anticancer therapy. Toxicol Appl Pharmacol. 2022 Jan 1;434:115797. doi: 10.1016/j.taap.2021.115797. Epub 2021 Nov 13.
79 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
80 Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42.
81 Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
82 Anti-androgenic effect of 6-formylindolo[3,2-b]carbazole (FICZ) in LNCaP cells is mediated by the aryl hydrocarbon-androgen receptors cross-talk. Steroids. 2020 Jan;153:108508. doi: 10.1016/j.steroids.2019.108508. Epub 2019 Oct 3.
83 Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition. Arch Toxicol. 2008 Dec;82(12):909-21.
84 Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density. J Bone Miner Res. 2005 Feb;20(2):232-9. doi: 10.1359/JBMR.041110. Epub 2004 Nov 16.
85 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
86 Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 1999 Feb 1;59(3):607-14.
87 Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
88 Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Gastroenterology. 2004 Nov;127(5):1436-45.
89 The inducibility of human cytochrome P450 1A by environmental-relevant xenobiotics in the human hepatoma derived cell line HepG2. Environ Toxicol Pharmacol. 2009 Nov;28(3):370-8.
90 The relative role of CYP3A4 and CYP3A5 in eplerenone metabolism. Toxicol Lett. 2019 Oct 15;315:9-13.
91 Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol. Chem Biol Interact. 2014 May 25;215:62-8.
92 Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells. Toxicol Sci. 2006 Jul;92(1):51-60.
93 The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis. Antimicrob Agents Chemother. 2004 Sep;48(9):3272-8.
94 Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos. 2001 Jan;29(1):30-5.
95 Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5591-4.
96 Mechanism-based inactivation of CYP3A by HIV protease inhibitors. J Pharmacol Exp Ther. 2005 Feb;312(2):583-91.
97 Studies of the toxicological potential of capsinoids, XIII: inhibitory effects of capsaicin and capsinoids on cytochrome P450 3A4 in human liver microsomes. Int J Toxicol. 2010 Mar;29(2 Suppl):22S-6S.
98 Investigation of the effects of axitinib on the pharmacokinetics of loperamide and its main metabolite N-demethylated loperamide in rats by UPLC-MS/MS. Chem Biol Interact. 2019 Sep 1;310:108744. doi: 10.1016/j.cbi.2019.108744. Epub 2019 Jul 9.
99 Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition. Drug Metab Dispos. 2003 Apr;31(4):439-46.
100 Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo. J Asian Nat Prod Res. 2012;14(4):382-95.
101 Potential of pranlukast and zafirlukast in the inhibition of human liver cytochrome P450 enzymes. Xenobiotica. 2004 May;34(5):429-38.
102 The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes. Life Sci. 2006 Nov 25;79(26):2432-40.
103 Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors. Chem Biol Interact. 2004 Apr 15;147(3):331-40.
104 Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class. Toxicol Lett. 2016 Jan 22;241:82-94.
105 Stiripentol. Expert Opin Investig Drugs. 2005 Jul;14(7):905-11.
106 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
107 Characteristics of P388/VMDRC.04, a simple, sensitive model for studying P-glycoprotein antagonists. Cancer Res. 1994 Feb 1;54(3):730-7.
108 Michaelis-Menten kinetic analysis of drugs of abuse to estimate their affinity to human P-glycoprotein. Toxicol Lett. 2013 Feb 27;217(2):137-42. doi: 10.1016/j.toxlet.2012.12.012. Epub 2012 Dec 27.
109 Editor's Highlight: PlacentalDisposition and Effects of Crizotinib: An Ex Vivo Study in the Isolated Dual-Side Perfused Human Cotyledon. Toxicol Sci. 2017 Jun 1;157(2):500-509. doi: 10.1093/toxsci/kfx063.
110 Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs. Pharmacogenet Genomics. 2008 May;18(5):390-402. doi: 10.1097/FPC.0b013e3282f85e36.
111 Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells. Cancer Sci. 2005 Jun;96(6):372-6. doi: 10.1111/j.1349-7006.2005.00057.x.
112 Clinical pharmacokinetic monitoring of itraconazole is warranted in only a subset of patients. Ther Drug Monit. 2005 Jun;27(3):322-33. doi: 10.1097/01.ftd.0000150135.22645.ea.
113 Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein. Psychopharmacology (Berl). 2006 Sep;187(4):415-23. doi: 10.1007/s00213-006-0437-9. Epub 2006 Jun 30.
114 Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro. Haematologica. 2002 Feb;87(2):167-76.
115 Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells. Cancer Res. 1988 Sep 1;48(17):4926-32.
116 Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents. Curr Drug Metab. 2006 Oct;7(7):745-53.
117 Methotrexate induction of human sulfotransferases in Hep G2 and Caco-2 cells. J Appl Toxicol. 2005 Sep-Oct;25(5):354-60.
118 Development and validation of a fluorescence HPLC-based screening assay for inhibition of human estrogen sulfotransferase. Anal Biochem. 2006 Oct 1;357(1):85-92.
119 Solvent effect on cDNA-expressed human sulfotransferase (SULT) activities in vitro. Drug Metab Dispos. 2003 Nov;31(11):1300-5.
120 Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
121 Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
122 CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
123 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
124 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
125 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
126 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
127 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
128 Gonadal steroids regulate GABAA receptor subunit mRNA expression in NT2-N neurons. Brain Res Mol Brain Res. 2005 Aug 18;138(2):105-15. doi: 10.1016/j.molbrainres.2004.10.047.
129 HOXA10 regulates endometrial GABAA {pi} receptor expression and membrane translocation. Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E889-93. doi: 10.1152/ajpendo.00577.2009. Epub 2010 Jan 26.
130 Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
131 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
132 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
133 Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
134 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
135 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
136 Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
137 Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
138 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
139 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
140 Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
141 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
142 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
143 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
144 Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
145 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
146 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
147 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
148 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
149 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
150 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
151 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
152 Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
153 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
154 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
155 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
156 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
157 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
158 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
159 Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Arch Toxicol. 2020 Dec;94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. Epub 2020 Aug 17.
160 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
161 MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
162 Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
163 Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
164 Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
165 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
166 Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
167 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
168 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
169 Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
170 Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
171 The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells. Chem Biol Interact. 2019 Apr 1;302:28-35. doi: 10.1016/j.cbi.2019.01.033. Epub 2019 Jan 28.
172 Musashi-1 promotes chemoresistant granule formation by PKR/eIF2 signalling cascade in refractory glioblastoma. Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1850-1861. doi: 10.1016/j.bbadis.2018.02.017. Epub 2018 Feb 24.
173 Expression of estrogen-, progesterone-, and androgen-responsive genes in MCF-7 and MDA-MB-231 cells treated with o,p'-DDT, p,p'-DDT, or endosulfan. J Biochem Mol Toxicol. 2021 Jun;35(6):1-8. doi: 10.1002/jbt.22773. Epub 2021 Mar 16.
174 Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.
175 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
176 Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
177 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
178 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
179 A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
180 Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
181 Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
182 Profile of estrogen-responsive genes in an estrogen-specific mammary gland outgrowth model. Mol Reprod Dev. 2009 Aug;76(8):733-50. doi: 10.1002/mrd.21041.
183 Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
184 Comprehensive transcriptome profiling of BET inhibitor-treated HepG2 cells. PLoS One. 2022 Apr 29;17(4):e0266966. doi: 10.1371/journal.pone.0266966. eCollection 2022.
185 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
186 Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
187 Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
188 Bisphenol A and bisphenol S induce distinct transcriptional profiles in differentiating human primary preadipocytes. PLoS One. 2016 Sep 29;11(9):e0163318.
189 Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
190 PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62.
191 Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
192 In vivo and in vitro dysferlin expression in human muscle satellite cells. J Neuropathol Exp Neurol. 2004 Oct;63(10):1104-13. doi: 10.1093/jnen/63.10.1104.
193 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
194 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
195 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
196 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
197 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
198 The disruption of L-carnitine metabolism by aluminum toxicity and oxidative stress promotes dyslipidemia in human astrocytic and hepatic cells. Toxicol Lett. 2011 Jun 24;203(3):219-26. doi: 10.1016/j.toxlet.2011.03.019. Epub 2011 Mar 23.
199 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
200 Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
201 Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
202 Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):117-27.
203 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
204 Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
205 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
206 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
207 Microarray analysis of bicalutamide action on telomerase activity, p53 pathway and viability of prostate carcinoma cell lines. J Pharm Pharmacol. 2005 Jan;57(1):83-92.
208 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
209 The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
210 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
211 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
212 Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod. 2011 Jul;26(7):1813-25.
213 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
214 Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
215 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
216 Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells. Mol Cancer Ther. 2012 Oct;11(10):2138-48. doi: 10.1158/1535-7163.MCT-12-0562. Epub 2012 Aug 6.
217 Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long-term to Zidovudine. Environ Mol Mutagen. 2007 Apr-May;48(3-4):179-89. doi: 10.1002/em.20245.
218 Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
219 Human 3D multicellular microtissues: an upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity. Toxicol Lett. 2019 Sep 15;312:34-44.
220 Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
221 4-HPR modulates gene expression in ovarian cells. Int J Cancer. 2006 Sep 1;119(5):1005-13. doi: 10.1002/ijc.21797.
222 Hydrocortisone enhances the barrier properties of HBMEC/ci, a brain microvascular endothelial cell line, through mesenchymal-to-endothelial transition-like effects. Fluids Barriers CNS. 2015 Mar 5;12:7. doi: 10.1186/s12987-015-0003-0. eCollection 2015.
223 Multiple treatments with L-3,4-dihydroxyphenylalanine modulate dopamine biosynthesis and neurotoxicity through the protein kinase A-transient extracellular signal-regulated kinase and exchange protein activation by cyclic AMP-sustained extracellular signal-regulated kinase signaling pathways. J Neurosci Res. 2014 Dec;92(12):1746-56. doi: 10.1002/jnr.23450. Epub 2014 Jul 12.
224 Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
225 The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent. Toxicology. 2010 Apr 11;270(2-3):137-49. doi: 10.1016/j.tox.2010.02.008. Epub 2010 Feb 17.
226 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
227 The organochlorine o,p'-DDT plays a role in coactivator-mediated MAPK crosstalk in MCF-7 breast cancer cells. Environ Health Perspect. 2012 Sep;120(9):1291-6. doi: 10.1289/ehp.1104296. Epub 2012 May 18.
228 Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
229 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
230 Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
231 Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
232 Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
233 RNAi-mediated knockdown of aldehyde dehydrogenase class-1A1 and class-3A1 is specific and reveals that each contributes equally to the resistance against 4-hydroperoxycyclophosphamide. Cancer Chemother Pharmacol. 2007 Jan;59(1):127-36. doi: 10.1007/s00280-006-0233-6. Epub 2006 Apr 14.
234 A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
235 Inhibition of aldehyde dehydrogenase-1 and p-glycoprotein-mediated multidrug resistance by curcumin and vitamin D3 increases sensitivity to paclitaxel in breast cancer. Chem Biol Interact. 2020 Jan 5;315:108865. doi: 10.1016/j.cbi.2019.108865. Epub 2019 Oct 16.
236 The interaction of disulfiram and H(2)S metabolism in inhibition of aldehyde dehydrogenase activity and liver cancer cell growth. Toxicol Appl Pharmacol. 2021 Sep 1;426:115642. doi: 10.1016/j.taap.2021.115642. Epub 2021 Jul 6.
237 Indomethacin activates carbonic anhydrase and antagonizes the effect of the specific carbonic anhydrase inhibitor acetazolamide, by a direct mechanism of action. Int J Clin Pharmacol Ther. 2001 Jun;39(6):265-70.
238 Effects of beta-adrenergic agonists on bone-resorbing activity in human osteoclast-like cells. Biochim Biophys Acta. 2003 May 12;1640(2-3):137-42.
239 Inhibition profiling of human carbonic anhydrase II by high-throughput screening of structurally diverse, biologically active compounds. J Biomol Screen. 2006 Oct;11(7):782-91.
240 Design, synthesis, and biological evaluation of novel carbohydrate-based sulfamates as carbonic anhydrase inhibitors. J Med Chem. 2011 Mar 10;54(5):1481-9.
241 Inhibition profiles of Voriconazole against acetylcholinesterase, -glycosidase, and human carbonic anhydrase I and II isoenzymes. J Biochem Mol Toxicol. 2019 Oct;33(10):e22385. doi: 10.1002/jbt.22385. Epub 2019 Sep 3.
242 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
243 Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro. Toxicol Sci. 2003 Aug;74(2):260-70. doi: 10.1093/toxsci/kfg113. Epub 2003 May 2.
244 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
245 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
246 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
247 Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937. Arthritis Res Ther. 2014 Jan 20;16(1):R17. doi: 10.1186/ar4444.
248 Simvastatin inhibits NOR-1 expression induced by hyperlipemia by interfering with CREB activation. Cardiovasc Res. 2005 Aug 1;67(2):333-41. doi: 10.1016/j.cardiores.2005.03.016. Epub 2005 Apr 21.
249 The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells. J Biol Chem. 2004 Jun 25;279(26):27008-16. doi: 10.1074/jbc.M403588200. Epub 2004 Apr 16.
250 Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-kappaB activity. Toxicol Sci. 2002 Apr;66(2):233-43. doi: 10.1093/toxsci/66.2.233.
251 ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2007 May;6(5):1579-87. doi: 10.1158/1535-7163.MCT-06-0814.
252 Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
253 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
254 Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
255 Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. Cancer Res. 2002 Nov 1;62(21):6006-10.
256 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
257 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
258 Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
259 The psychoactive substance of cannabis 9-tetrahydrocannabinol (THC) negatively regulates CFTR in airway cells. Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):1988-1994. doi: 10.1016/j.bbagen.2018.06.008. Epub 2018 Jun 19.
260 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
261 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
262 All-trans-retinoic acid inhibits collapsin response mediator protein-2 transcriptional activity during SH-SY5Y neuroblastoma cell differentiation. FEBS J. 2007 Jan;274(2):498-511. doi: 10.1111/j.1742-4658.2006.05597.x.
263 Molecular targeting of retinoic acid metabolism in neuroblastoma: the role of the CYP26 inhibitor R116010 in vitro and in vivo. Br J Cancer. 2007 Jun 4;96(11):1675-83.
264 [Impact of arsenic trioxide on proliferation and metastasis of drug-resistant human ovarian carcinoma cell line]. Ai Zheng. 2002 Aug;21(8):863-7.
265 Biological specificity of CDK4/6 inhibitors: dose response relationship, in vivo signaling, and composite response signature. Oncotarget. 2017 Jul 4;8(27):43678-43691. doi: 10.18632/oncotarget.18435.
266 IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression. Mol Cancer. 2023 May 29;22(1):88. doi: 10.1186/s12943-023-01792-0.
267 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
268 Proteomic analysis of anti-cancer effects by paclitaxel treatment in cervical cancer cells. Gynecol Oncol. 2005 Jul;98(1):45-53. doi: 10.1016/j.ygyno.2005.04.010.
269 Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
270 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
271 Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nat Commun. 2018 Aug 9;9(1):3069. doi: 10.1038/s41467-018-05402-2.
272 The psychoactive compound of Cannabis sativa, (9)-tetrahydrocannabinol (THC) inhibits the human trophoblast cell turnover. Toxicology. 2015 Aug 6;334:94-103. doi: 10.1016/j.tox.2015.06.005. Epub 2015 Jun 9.
273 The effects of desmethylimipramine on cyclic AMP-stimulated gene transcription in a model cell system. Biochem Pharmacol. 2005 Sep 1;70(5):762-9. doi: 10.1016/j.bcp.2005.06.012.
274 Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells. Biochemistry. 2007 Aug 7;46(31):8920-32. doi: 10.1021/bi7000328. Epub 2007 Jul 14.
275 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
276 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
277 Use of transcriptomics in hazard identification and next generation risk assessment: A case study with clothianidin. Food Chem Toxicol. 2022 Aug;166:113212. doi: 10.1016/j.fct.2022.113212. Epub 2022 Jun 8.
278 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
279 Effects of the environmental estrogens bisphenol A, o,p'-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7. J Steroid Biochem Mol Biol. 2002 Jan;80(1):61-70. doi: 10.1016/s0960-0760(01)00173-x.
280 Conception and pharmacodynamic profile of drospirenone. Steroids. 2003 Nov;68(10-13):891-905. doi: 10.1016/j.steroids.2003.08.008.
281 Biological activity of all-trans-retinoic acid with and without tamoxifen and alpha-interferon 2a in breast cancer patients. Int J Oncol. 2000 Nov;17(5):991-1000. doi: 10.3892/ijo.17.5.991.
282 Estrogen-induced loss of progesterone receptor expression in normal and malignant ovarian surface epithelial cells. Oncogene. 2005 Jun 23;24(27):4388-400. doi: 10.1038/sj.onc.1208623.
283 Tibolone and its metabolites enhance tissue factor and PAI-1 expression in human endometrial stromal cells: Evidence of progestogenic effects. Steroids. 2005 Nov;70(12):840-5. doi: 10.1016/j.steroids.2005.04.010.
284 Characterization of the weak estrogen receptor alpha agonistic activity of exemestane. Breast Cancer Res Treat. 2009 Aug;116(3):461-70. doi: 10.1007/s10549-008-0151-x. Epub 2008 Aug 3.
285 A comparative study of the effect of raloxifene and gosereline on uterine leiomyoma volume changes and estrogen receptor, progesterone receptor, bcl-2 and p53 expression immunohistochemically in premenopausal women. Eur J Obstet Gynecol Reprod Biol. 2007 Nov;135(1):94-103. doi: 10.1016/j.ejogrb.2006.07.042. Epub 2006 Sep 14.
286 Serum free BG-1 cell proliferation assay: a sensitive method for determining organochlorine pesticide estrogen receptor activation at the nanomolar range. Toxicol In Vitro. 2006 Apr;20(3):382-94. doi: 10.1016/j.tiv.2005.08.016. Epub 2005 Oct 19.
287 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
288 Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
289 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
290 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
291 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
292 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
293 Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
294 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
295 Dimethyl Fumarate Therapy Significantly Improves the Responsiveness of T Cells in Multiple Sclerosis Patients for Immunoregulation by Regulatory T Cells. Int J Mol Sci. 2017 Jan 28;18(2):271. doi: 10.3390/ijms18020271.
296 In vitro antitumoral effects of the steroid ouabain on human thyroid papillary carcinoma cell lines. Environ Toxicol. 2021 Jul;36(7):1338-1348. doi: 10.1002/tox.23130. Epub 2021 Mar 24.
297 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
298 Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents. Leuk Res. 2010 Jul;34(7):917-24. doi: 10.1016/j.leukres.2009.12.002. Epub 2010 Feb 8.
299 Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells. Biochem J. 1991 Aug 1;277 ( Pt 3)(Pt 3):659-64. doi: 10.1042/bj2770659.
300 Nobiletin, a citrus flavonoid, down-regulates matrix metalloproteinase-7 (matrilysin) expression in HT-29 human colorectal cancer cells. Biosci Biotechnol Biochem. 2005 Feb;69(2):307-14. doi: 10.1271/bbb.69.307.
301 Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
302 The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
303 Effect of mood stabilizers on gene expression in lymphoblastoid cells. J Neural Transm (Vienna). 2010 Feb;117(2):155-64.
304 Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses. Immunology. 2007 Jun;121(2):266-75. doi: 10.1111/j.1365-2567.2007.02574.x. Epub 2007 Mar 7.
305 AMPK-dependent signaling modulates the suppression of invasion and migration by fenofibrate in CAL 27 oral cancer cells through NF-B pathway. Environ Toxicol. 2016 Jul;31(7):866-76. doi: 10.1002/tox.22097. Epub 2014 Dec 24.
306 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
307 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
308 Molecular and metabolic retinoid pathways in human amniotic membranes. Biochem Biophys Res Commun. 2006 Aug 11;346(4):1207-16. doi: 10.1016/j.bbrc.2006.06.024. Epub 2006 Jun 12.
309 The retinoid anticancer signal: mechanisms of target gene regulation. Br J Cancer. 2005 Aug 8;93(3):310-8. doi: 10.1038/sj.bjc.6602700.
310 A repressive epigenetic domino effect confers susceptibility to breast epithelial cell transformation: implications for predicting breast cancer risk. Cancer Res. 2006 Nov 1;66(21):10308-14. doi: 10.1158/0008-5472.CAN-06-1052.
311 Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
312 Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
313 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
314 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
315 Analysis of estrogen agonism and antagonism of tamoxifen, raloxifene, and ICI182780 in endometrial cancer cells: a putative role for the epidermal growth factor receptor ligand amphiregulin. J Soc Gynecol Investig. 2005 Oct;12(7):e55-67.
316 Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol Rep. 2006 Jun;15(6):1453-60.
317 Estrogenic and genotoxic potential of equol and two hydroxylated metabolites of Daidzein in cultured human Ishikawa cells. Toxicol Lett. 2005 Jul 28;158(1):72-86. doi: 10.1016/j.toxlet.2005.02.011. Epub 2005 Apr 11.
318 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
319 Effect of benzo[a]pyrene on proliferation and metastasis of oral squamous cell carcinoma cells: A transcriptome analysis based on RNA-seq. Environ Toxicol. 2022 Nov;37(11):2589-2604. doi: 10.1002/tox.23621. Epub 2022 Jul 23.
320 Transcriptomic?pathway?and?benchmark dose analysis of Bisphenol A, Bisphenol S, Bisphenol F, and 3,3',5,5'-Tetrabromobisphenol A in H9 human embryonic stem cells. Toxicol In Vitro. 2021 Apr;72:105097. doi: 10.1016/j.tiv.2021.105097. Epub 2021 Jan 18.
321 Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
322 Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food Chem Toxicol. 2020 Feb;136:111047. doi: 10.1016/j.fct.2019.111047. Epub 2019 Dec 12.
323 Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain Res. 2008 Jan 29;1191:1-11.
324 Selenium is critical for cancer-signaling gene expression but not cell proliferation in human colon Caco-2 cells. Biofactors. 2007;31(3-4):155-64. doi: 10.1002/biof.5520310302.
325 Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
326 Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Mol Cell Biochem. 2010 Nov;344(1-2):173-84. doi: 10.1007/s11010-010-0540-4. Epub 2010 Jul 25.
327 Curcumin reduces the expression of survivin, leading to enhancement of arsenic trioxide-induced apoptosis in myelodysplastic syndrome and leukemia stem-like cells. Oncol Rep. 2016 Sep;36(3):1233-42. doi: 10.3892/or.2016.4944. Epub 2016 Jul 15.
328 DHT and testosterone, but not DHEA or E2, differentially modulate IGF-I, IGFBP-2, and IGFBP-3 in human prostatic stromal cells. Am J Physiol Endocrinol Metab. 2006 May;290(5):E952-60. doi: 10.1152/ajpendo.00451.2005. Epub 2005 Dec 20.
329 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
330 Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Int J Mol Sci. 2023 Mar 15;24(6):5604. doi: 10.3390/ijms24065604.
331 D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
332 Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
333 Ursodeoxycholic acid reduces increased circulating endothelin 2 in primary biliary cirrhosis. Aliment Pharmacol Ther. 2005 Feb 1;21(3):227-34. doi: 10.1111/j.1365-2036.2005.02307.x.
334 Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
335 Application of cDNA microarray to the study of arsenic-induced liver diseases in the population of Guizhou, China. Toxicol Sci. 2001 Jan;59(1):185-92.
336 Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals. Int J Mol Sci. 2021 Oct 12;22(20):11005. doi: 10.3390/ijms222011005.
337 Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan;92(1):469-485.
338 Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
339 Patterns of some extracellular matrix gene expression are similar in cells from cleft lip-palate patients and in human palatal fibroblasts exposed to diazepam in culture. Toxicology. 2009 Mar 4;257(1-2):10-6. doi: 10.1016/j.tox.2008.12.002. Epub 2008 Dec 9.
340 Modulation of fibroblast growth factor receptor expression and signalling during retinoic acid-induced differentiation of Tera-2 teratocarcinoma cells. Biochem Biophys Res Commun. 1993 Feb 26;191(1):149-56. doi: 10.1006/bbrc.1993.1196.
341 Thalidomide and Its Analogs Differentially Target Fibroblast Growth Factor Receptors: Thalidomide Suppresses FGFR Gene Expression while Pomalidomide Dampens FGFR2 Activity. Chem Res Toxicol. 2019 Apr 15;32(4):589-602. doi: 10.1021/acs.chemrestox.8b00286. Epub 2019 Mar 15.
342 Discovery of molecular mechanisms of neuroprotection using cell-based bioassays and oligonucleotide arrays. Physiol Genomics. 2002 Oct 29;11(2):45-52. doi: 10.1152/physiolgenomics.00064.2002.
343 JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
344 Increased expression of fibroblast growth factor receptor 3 in CD34+ BCR-ABL+ cells from patients with chronic myeloid leukemia. Leukemia. 2003 Dec;17(12):2418-25. doi: 10.1038/sj.leu.2403152.
345 Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
346 Acetaminophen selectively suppresses peripheral prostaglandin E2 release and increases COX-2 gene expression in a clinical model of acute inflammation. Pain. 2007 Jun;129(3):279-86.
347 Mitochondrial involvement in schizophrenia and other functional psychoses. Neurochem Res. 1996 Sep;21(9):995-1004.
348 Quercetin reduces oxidative damage induced by paraquat via modulating expression of antioxidant genes in A549 cells. J Appl Toxicol. 2013 Dec;33(12):1460-7. doi: 10.1002/jat.2812. Epub 2012 Sep 20.
349 The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model. Anesth Analg. 2008 Jan;106(1):321-7, table of contents.
350 Effect of nephrotoxicants and hepatotoxicants on gene expression profile in human peripheral blood mononuclear cells. Biochem Biophys Res Commun. 2010 Oct 15;401(2):245-50. doi: 10.1016/j.bbrc.2010.09.039. Epub 2010 Sep 16.
351 Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
352 Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
353 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
354 Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
355 Docosahexaenoic acid regulates gene expression in HUVEC cells treated with polycyclic aromatic hydrocarbons. Toxicol Lett. 2015 Jul 16;236(2):75-81.
356 Etoposide induces necrosis through p53-mediated antiapoptosis in human kidney proximal tubule cells. Toxicol Sci. 2015 Nov;148(1):204-19.
357 Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. Br J Nutr. 2006 Nov;96(5):811-9.
358 COX-2 and PPAR-gama confer cannabidiol-induced apoptosis of human lung cancer cells. Mol Cancer Ther. 2013 Jan;12(1):69-82.
359 Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression. Eur Neuropsychopharmacol. 2007 Dec;17(12):774-80.
360 Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer. Cancer Res. 2006 Feb 15;66(4):2067-73.
361 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
362 A2E selectively induces cox-2 in ARPE-19 and human neural cells. Curr Eye Res. 2006 Mar;31(3):259-63.
363 Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci. 2014 Jun;139(2):328-37. doi: 10.1093/toxsci/kfu053. Epub 2014 Mar 27.
364 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
365 Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
366 Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell. 2004 Mar;15(3):1262-72. doi: 10.1091/mbc.e03-06-0360. Epub 2003 Dec 29.
367 The impact of luteal phase support on gene expression of extracellular matrix protein and adhesion molecules in the human endometrium during the window of implantation following controlled ovarian stimulation with a GnRH antagonist protocol. Fertil Steril. 2010 Nov;94(6):2264-71. doi: 10.1016/j.fertnstert.2010.01.068. Epub 2010 Mar 12.
368 Microarray-based detection and expression analysis of extracellular matrix proteins in drug?resistant ovarian cancer cell lines. Oncol Rep. 2014 Nov;32(5):1981-90. doi: 10.3892/or.2014.3468. Epub 2014 Sep 9.
369 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
370 Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
371 The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. Hum Reprod. 2010 Nov;25(11):2859-69.
372 Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
373 Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model. Environ Pollut. 2023 Oct 15;335:122359. doi: 10.1016/j.envpol.2023.122359. Epub 2023 Aug 9.
374 A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302. doi: 10.1371/journal.pone.0178302. eCollection 2017.
375 Atrial-like Engineered Heart Tissue: An In?Vitro Model of the Human Atrium. Stem Cell Reports. 2018 Dec 11;11(6):1378-1390. doi: 10.1016/j.stemcr.2018.10.008. Epub 2018 Nov 8.
376 Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
377 Expression of inwardly rectifying potassium channels (GIRKs) and beta-adrenergic regulation of breast cancer cell lines. BMC Cancer. 2004 Dec 16;4:93. doi: 10.1186/1471-2407-4-93.
378 Intestinal absorption of vitamins. Curr Opin Gastroenterol. 1999 Mar;15(2):172-6. doi: 10.1097/00001574-199903000-00015.
379 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
380 Differential protein expression of peroxiredoxin I and II by benzo(a)pyrene and quercetin treatment in 22Rv1 and PrEC prostate cell lines. Toxicol Appl Pharmacol. 2007 Apr 15;220(2):197-210. doi: 10.1016/j.taap.2006.12.030. Epub 2007 Jan 9.
381 Mechanistic and predictive profiling of 5-Fluorouracil resistance in human cancer cells. Cancer Res. 2004 Nov 15;64(22):8167-76. doi: 10.1158/0008-5472.CAN-04-0970.
382 TGF-1 signaling protects retinal ganglion cells from oxidative stress via modulation of the HO-1/Nrf2 pathway. Chem Biol Interact. 2020 Nov 1;331:109249. doi: 10.1016/j.cbi.2020.109249. Epub 2020 Sep 24.
383 Troglitazone suppresses transforming growth factor beta-mediated fibrogenesis in retinal pigment epithelial cells. Mol Vis. 2008 Jan 18;14:95-104.
384 Towards dissecting the pathogenesis of retinoid-induced hair loss: all-trans retinoic acid induces premature hair follicle regression (catagen) by upregulation of transforming growth factor-beta2 in the dermal papilla. J Invest Dermatol. 2005 Jun;124(6):1119-26. doi: 10.1111/j.0022-202X.2005.23686.x.
385 Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
386 Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
387 Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
388 How benzene and its metabolites affect human marrow derived mesenchymal stem cells. Toxicol Lett. 2012 Oct 17;214(2):145-53. doi: 10.1016/j.toxlet.2012.08.015. Epub 2012 Aug 30.
389 NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
390 Megalin genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin. Pharmacogenomics J. 2008 Feb;8(1):23-8. doi: 10.1038/sj.tpj.6500455. Epub 2007 Apr 24.
391 Thyroid organotypic rat and human cultures used to investigate drug effects on thyroid function, hormone synthesis and release pathways. Toxicol Appl Pharmacol. 2012 Apr 1;260(1):81-8. doi: 10.1016/j.taap.2012.01.029. Epub 2012 Feb 8.
392 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
393 Early Transcriptomic Changes upon Thalidomide Exposure Influence the Later Neuronal Development in Human Embryonic Stem Cell-Derived Spheres. Int J Mol Sci. 2020 Aug 3;21(15):5564. doi: 10.3390/ijms21155564.
394 Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
395 Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
396 Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
397 Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel. Toxicol Appl Pharmacol. 2014 Sep 1;279(2):163-72.
398 Effect of ovarian steroids on gene expression profile in human uterine microvascular endothelial cells. Fertil Steril. 2009 Aug;92(2):709-21.
399 Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells. Toxicol Appl Pharmacol. 2009 Feb 1;234(3):345-60.
400 Estrogen-responsive genes newly found to be modified by TCDD exposure in human cell lines and mouse systems. Mol Cell Endocrinol. 2007 Jun 30;272(1-2):38-49.
401 Immediate up-regulation of the calcium-binding protein S100P and its involvement in the cytokinin-induced differentiation of human myeloid leukemia cells. Biochim Biophys Acta. 2005 Sep 10;1745(2):156-65.
402 Dynamic activation of cystic fibrosis transmembrane conductance regulator by type 3 and type 4D phosphodiesterase inhibitors. J Pharmacol Exp Ther. 2005 Aug;314(2):846-54. doi: 10.1124/jpet.105.083519. Epub 2005 May 18.
403 Effect of prenatal arsenic exposure on DNA methylation and leukocyte subpopulations in cord blood. Epigenetics. 2014 May;9(5):774-82. doi: 10.4161/epi.28153. Epub 2014 Feb 13.
404 Quantitative Assessment of Arsenite-Induced Perturbation of Ubiquitinated Proteome. Chem Res Toxicol. 2022 Sep 19;35(9):1589-1597. doi: 10.1021/acs.chemrestox.2c00197. Epub 2022 Aug 22.
405 Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20;2:55. doi: 10.1186/1755-8794-2-55.
406 Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
407 Additive beneficial cardiovascular and metabolic effects of combination therapy with ramipril and candesartan in hypertensive patients. Eur Heart J. 2007 Jun;28(12):1440-7. doi: 10.1093/eurheartj/ehm101. Epub 2007 May 5.
408 Adipogenic Effects and Gene Expression Profiling of Firemaster? 550 Components in Human Primary Preadipocytes. Environ Health Perspect. 2017 Sep 14;125(9):097013. doi: 10.1289/EHP1318.
409 Combination of an ACE inhibitor and indapamide improves blood pressure control, but attenuates the beneficial effects of ACE inhibition on plasma adiponectin in patients with essential hypertension. Circ J. 2009 Dec;73(12):2282-7. doi: 10.1253/circj.cj-09-0387. Epub 2009 Sep 29.
410 Role of PML SUMOylation in arsenic trioxide-induced fibrosis in HSCs. Life Sci. 2020 Jun 15;251:117607. doi: 10.1016/j.lfs.2020.117607. Epub 2020 Mar 30.
411 Effects of nevirapine and efavirenz on human adipocyte differentiation, gene expression, and release of adipokines and cytokines. Antiviral Res. 2011 Aug;91(2):112-9. doi: 10.1016/j.antiviral.2011.04.018. Epub 2011 May 17.
412 (9)-Tetrahydrocannabinol upregulates fatty acid 2-hydroxylase (FA2H) via PPAR induction: A possible evidence for the cancellation of PPAR/-mediated inhibition of PPAR in MDA-MB-231?cells. Arch Biochem Biophys. 2019 Feb 15;662:219-225. doi: 10.1016/j.abb.2018.12.011. Epub 2018 Dec 13.
413 Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions. BMC Genomics. 2008 Aug 7;9:376.
414 Different pathways are involved in arsenic-trioxide-induced cell proliferation and growth inhibition in human keratinocytes. Skin Pharmacol Physiol. 2010;23(2):68-78. doi: 10.1159/000265677. Epub 2009 Dec 14.
415 Gene expression changes in primary human nasal epithelial cells exposed to formaldehyde in vitro. Toxicol Lett. 2010 Oct 5;198(2):289-95.
416 A Gene Expression Biomarker Identifies Chemical Modulators of Estrogen Receptor in an MCF-7 Microarray Compendium. Chem Res Toxicol. 2021 Feb 15;34(2):313-329. doi: 10.1021/acs.chemrestox.0c00243. Epub 2021 Jan 6.
417 Arsenic induces functional re-expression of estrogen receptor by demethylation of DNA in estrogen receptor-negative human breast cancer. PLoS One. 2012;7(4):e35957. doi: 10.1371/journal.pone.0035957. Epub 2012 Apr 27.
418 Evaluation of an imaging-based in vitro screening platform for estrogenic activity with OECD reference chemicals. Toxicol In Vitro. 2022 Jun;81:105348. doi: 10.1016/j.tiv.2022.105348. Epub 2022 Mar 18.
419 Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
420 The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
421 Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
422 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Pharmacogenomics J. 2014 Feb;14(1):35-40. doi: 10.1038/tpj.2013.3. Epub 2013 Feb 12.
423 Nimodipine inhibits intestinal and aortic smooth muscle contraction by regulating Ca(2+)-activated Cl(-) channels. Toxicol Appl Pharmacol. 2021 Jun 15;421:115543. doi: 10.1016/j.taap.2021.115543. Epub 2021 Apr 16.
424 Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011 Feb 18;24(2):165-7. doi: 10.1021/tx1004419. Epub 2011 Feb 4.
425 A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor. Sleep. 2012 Jul 1;35(7):967-75. doi: 10.5665/sleep.1962.
426 Inorganic arsenic exposure promotes malignant progression by HDAC6-mediated down-regulation of HTRA1. J Appl Toxicol. 2023 Aug;43(8):1214-1224. doi: 10.1002/jat.4457. Epub 2023 Mar 11.
427 Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
428 Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
429 Prediction of doxorubicin sensitivity in breast tumors based on gene expression profiles of drug-resistant cell lines correlates with patient survival. Oncogene. 2005 Nov 17;24(51):7542-51. doi: 10.1038/sj.onc.1208908.
430 Gene expression profile analysis of gallic acid-induced cell death process. Sci Rep. 2021 Aug 18;11(1):16743. doi: 10.1038/s41598-021-96174-1.
431 Fenfluramine-induced gene dysregulation in human pulmonary artery smooth muscle and endothelial cells. Pulm Circ. 2011 Jul-Sep;1(3):405-18. doi: 10.4103/2045-8932.87310.
432 Comparison of transcriptome expression alterations by chronic exposure to low-dose bisphenol A in different subtypes of breast cancer cells. Toxicol Appl Pharmacol. 2019 Dec 15;385:114814. doi: 10.1016/j.taap.2019.114814. Epub 2019 Nov 9.
433 Expression and DNA methylation changes in human breast epithelial cells after bisphenol A exposure. Int J Oncol. 2012 Jul;41(1):369-77.
434 Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2011 Feb;123(3-5):140-50.
435 Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells. Environ Health Perspect. 2015 Jan;123(1):80-7. doi: 10.1289/ehp.1408437. Epub 2014 Aug 19.
436 Differently expressed long noncoding RNAs and mRNAs in TK6 cells exposed to low dose hydroquinone. Oncotarget. 2017 Oct 4;8(56):95554-95567. doi: 10.18632/oncotarget.21481. eCollection 2017 Nov 10.
437 Malathion induced cancer-linked gene expression in human lymphocytes. Environ Res. 2020 Mar;182:109131. doi: 10.1016/j.envres.2020.109131. Epub 2020 Jan 10.
438 Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49. doi: 10.1016/j.placenta.2019.10.008. Epub 2019 Oct 17.
439 Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells. J Biol Chem. 2017 Feb 17;292(7):2815-2829. doi: 10.1074/jbc.M116.745398. Epub 2017 Jan 4.
440 Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes. Chem Biol Interact. 2009 May 15;179(2-3):288-96.
441 Hypermethylation of the nel-like 1 gene is a common and early event and is associated with poor prognosis in early-stage esophageal adenocarcinoma. Oncogene. 2007 Sep 20;26(43):6332-40. doi: 10.1038/sj.onc.1210461. Epub 2007 Apr 23.
442 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
443 Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions. Pharmacogenomics. 2012 Mar;13(4):399-405. doi: 10.2217/pgs.11.165.
444 Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
445 Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer. Cancer Biol Ther. 2009 Jul;8(14):1328-39. doi: 10.4161/cbt.8.14.8633. Epub 2009 Jul 6.
446 Differential regulation of proliferation, cell cycle control and gene expression in cultured human aortic and pulmonary artery endothelial cells by resveratrol. Int J Mol Med. 2010 Nov;26(5):743-9.
447 Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
448 Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. Mol Cell. 2006 Nov 3;24(3):341-54. doi: 10.1016/j.molcel.2006.10.019.
449 DNA methylation inhibits p53-mediated survivin repression. Oncogene. 2009 May 14;28(19):2046-50. doi: 10.1038/onc.2009.62. Epub 2009 Apr 13.
450 Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
451 Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
452 Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
453 Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
454 Characterizing the genetic basis for nicotine induced cancer development: a transcriptome sequencing study. PLoS One. 2013 Jun 18;8(6):e67252.
455 Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB. Carcinogenesis. 2008 Apr;29(4):779-89.
456 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
457 Regulation of chromatin assembly and cell transformation by formaldehyde exposure in human cells. Environ Health Perspect. 2017 Sep 21;125(9):097019.
458 Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines. Chem Biol Interact. 2010 Oct 6;188(1):214-9.
459 Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
460 Isoproterenol effects evaluated in heart slices of human and rat in comparison to rat heart in vivo. Toxicol Appl Pharmacol. 2014 Jan 15;274(2):302-12.
461 Estrogen receptor alpha (ER)-mediated coregulator binding and gene expression discriminates the toxic ER agonist diethylstilbestrol (DES) from the endogenous ER agonist 17-estradiol (E2). Cell Biol Toxicol. 2020 Oct;36(5):417-435. doi: 10.1007/s10565-020-09516-6. Epub 2020 Feb 22.
462 Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 2009 Aug 21;138(4):645-659. doi: 10.1016/j.cell.2009.06.034. Epub 2009 Aug 13.
463 Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. doi: 10.1002/cam4.1179. Epub 2017 Sep 27.
464 Use of human neuroblastoma SH-SY5Y cells to evaluate glyphosate-induced effects on oxidative stress, neuronal development and cell death signaling pathways. Environ Int. 2020 Feb;135:105414. doi: 10.1016/j.envint.2019.105414. Epub 2019 Dec 23.
465 Persistence of epigenomic effects after recovery from repeated treatment with two nephrocarcinogens. Front Genet. 2018 Dec 3;9:558.
466 Cellular reactions to long-term volatile organic compound (VOC) exposures. Sci Rep. 2016 Dec 1;6:37842. doi: 10.1038/srep37842.
467 Arsenic-induced sumoylation of Mus81 is involved in regulating genomic stability. Cell Cycle. 2017 Apr 18;16(8):802-811. doi: 10.1080/15384101.2017.1302628. Epub 2017 Mar 20.
468 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
469 10mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furin. Osteoarthritis Cartilage. 2010 Mar;18(3):455-63. doi: 10.1016/j.joca.2009.10.014. Epub 2009 Nov 4.
470 Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells. Toxicol Appl Pharmacol. 2017 Sep 15;331:154-163.
471 Troglitazone induces cytotoxicity in part by promoting the degradation of peroxisome proliferator-activated receptor co-activator-1 protein. Br J Pharmacol. 2010 Oct;161(4):771-81. doi: 10.1111/j.1476-5381.2010.00900.x.
472 Effects of four-week high-fructose diet on gene expression in skeletal muscle of healthy men. Diabetes Metab. 2008 Feb;34(1):82-5. doi: 10.1016/j.diabet.2007.08.004. Epub 2007 Dec 11.
473 Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells. Diabetologia. 2010 May;53(5):955-65. doi: 10.1007/s00125-010-1676-1. Epub 2010 Feb 18.
474 AMPK activator acadesine fails to alleviate isoniazid-caused mitochondrial instability in HepG2 cells. J Appl Toxicol. 2017 Oct;37(10):1219-1224. doi: 10.1002/jat.3483. Epub 2017 May 29.
475 Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis. Toxicol Appl Pharmacol. 2016 Jul 1;302:1-9. doi: 10.1016/j.taap.2016.04.007. Epub 2016 Apr 16.
476 A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1 expression and mitochondrial biogenesis. PLoS One. 2012;7(10):e46753. doi: 10.1371/journal.pone.0046753. Epub 2012 Oct 3.
477 Folic acid modulates cancer-associated micro RNAs and inflammatory mediators in neoplastic and non-neoplastic colonic cells in a different way. Mol Nutr Food Res. 2017 Dec;61(12). doi: 10.1002/mnfr.201700260. Epub 2017 Nov 9.
478 Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
479 Interactive gene expression pattern in prostate cancer cells exposed to phenolic antioxidants. Life Sci. 2002 Mar 1;70(15):1821-39.
480 Copper deprivation enhances the chemosensitivity of pancreatic cancer to rapamycin by mTORC1/2 inhibition. Chem Biol Interact. 2023 Sep 1;382:110546. doi: 10.1016/j.cbi.2023.110546. Epub 2023 Jun 7.
481 Inter- and intra-laboratory study to determine the reproducibility of toxicogenomics datasets. Toxicology. 2011 Nov 28;290(1):50-8.
482 Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. BMC Cancer. 2007 Dec 11;7:223.
483 Expression pattern of cisplatin-induced metallothionein isoforms in squamous cell carcinoma. Anticancer Res. 2003 Jan-Feb;23(1A):299-303.
484 Identification of novel activators of the metal responsive transcription factor (MTF-1) using a gene expression biomarker in a microarray compendium. Metallomics. 2020 Sep 23;12(9):1400-1415. doi: 10.1039/d0mt00071j.
485 Expression of antioxidant proteins in human intestinal Caco-2 cells treated with dietary flavonoids. Cancer Lett. 1999 Nov 15;146(2):161-7.
486 Oxidative stress modulates expression of immune checkpoint genes via activation of AhR signaling. Toxicol Appl Pharmacol. 2022 Dec 15;457:116314. doi: 10.1016/j.taap.2022.116314. Epub 2022 Nov 9.
487 Profiling of enantiopure drugs towards aryl hydrocarbon (AhR), glucocorticoid (GR) and pregnane X (PXR) receptors in human reporter cell lines. Chem Biol Interact. 2014 Feb 5;208:64-76. doi: 10.1016/j.cbi.2013.11.018. Epub 2013 Dec 6.
488 Involvement of cytoskeleton in AhR-dependent CYP1A1 expression. Curr Drug Metab. 2006 Apr;7(3):301-13. doi: 10.2174/138920006776359310.
489 Sulindac and its metabolites induce carcinogen metabolizing enzymes in human colon cancer cells. Int J Cancer. 2008 Mar 1;122(5):990-8.
490 Quercetin, quercetin glycosides and taxifolin differ in their ability to induce AhR activation and CYP1A1 expression in HepG2 cells. Phytother Res. 2012 Nov;26(11):1746-52.
491 Omeprazole inhibits pancreatic cancer cell invasion through a nongenomic aryl hydrocarbon receptor pathway. Chem Res Toxicol. 2015 May 18;28(5):907-18.
492 Expression and inducibility of cytochrome P450s (CYP1A1, 2B6, 2E1, 3A4) in human cord blood CD34(+) stem cell-derived differentiating neuronal cells. Toxicol Sci. 2012 Oct;129(2):392-410.
493 Induction of paraoxonase 1 and apolipoprotein A-I gene expression by aspirin. J Lipid Res. 2008 Oct;49(10):2142-8.
494 Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
495 Tetramethylpyrazine alleviates iron overload damage in vascular endothelium via upregulating DDAHII expression. Toxicol In Vitro. 2020 Jun;65:104817. doi: 10.1016/j.tiv.2020.104817. Epub 2020 Mar 2.
496 Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells. Br J Pharmacol. 2013 May;169(1):167-78.
497 Resistance in vitro to low-dose aspirin is associated with platelet PlA1 (GP IIIa) polymorphism but not with C807T(GP Ia/IIa) and C-5T Kozak (GP Ibalpha) polymorphisms. J Am Coll Cardiol. 2003 Sep 17;42(6):1115-9. doi: 10.1016/s0735-1097(03)00921-5.
498 Pro-apoptotic role of integrin 3 in glioma cells. J Neurochem. 2011 May;117(3):494-503. doi: 10.1111/j.1471-4159.2011.07219.x. Epub 2011 Mar 15.
499 In vitro dual effect of arsenic trioxide on hemopoiesis: inhibition of erythropoiesis and stimulation of megakaryocytic maturation. Blood Cells Mol Dis. 2006 Jan-Feb;36(1):59-76. doi: 10.1016/j.bcmd.2005.10.005. Epub 2005 Dec 15.
500 Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. Neurotoxicology. 2015 Sep;50:56-70.
501 Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake. Obesity (Silver Spring). 2010 Jan;18(1):27-34. doi: 10.1038/oby.2009.208. Epub 2009 Jun 25.
502 Pretreatment of 3-MA prevents doxorubicin-induced cardiotoxicity through inhibition of autophagy initiation. Toxicology. 2023 May 15;490:153512. doi: 10.1016/j.tox.2023.153512. Epub 2023 Apr 14.
503 Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. Pharmacogenet Genomics. 2006 Apr;16(4):287-96. doi: 10.1097/01.fpc.0000189800.88596.7a.
504 Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
505 Identification of biomarkers modulated by the rexinoid LGD1069 (bexarotene) in human breast cells using oligonucleotide arrays. Cancer Res. 2006 Dec 15;66(24):12009-18.
506 Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. PLoS One. 2007 Nov 14;2(11):e1187. doi: 10.1371/journal.pone.0001187.
507 Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
508 Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
509 Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells. J Pharmacol Exp Ther. 2003 Jun;305(3):932-42. doi: 10.1124/jpet.103.049098. Epub 2003 Mar 20.
510 Retinoid targeting of different D-type cyclins through distinct chemopreventive mechanisms. Cancer Res. 2005 Jul 15;65(14):6476-83. doi: 10.1158/0008-5472.CAN-05-0370.
511 Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
512 1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells. Cell Struct Funct. 2005;30(1):1-6. doi: 10.1247/csf.30.1.
513 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
514 Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells. Reprod Toxicol. 2020 Jan;91:74-91. doi: 10.1016/j.reprotox.2019.10.004. Epub 2019 Nov 8.
515 Differential effects of omega-3 and omega-6 Fatty acids on gene expression in breast cancer cells. Breast Cancer Res Treat. 2007 Jan;101(1):7-16. doi: 10.1007/s10549-006-9269-x. Epub 2006 Jul 6.
516 Evaluation of developmental toxicity using undifferentiated human embryonic stem cells. J Appl Toxicol. 2015 Feb;35(2):205-18.
517 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
518 A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
519 In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies. Toxicol Sci. 2007 Sep;99(1):162-73.
520 Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J Nutr Biochem. 2007 Aug;18(8):541-52. doi: 10.1016/j.jnutbio.2006.11.002. Epub 2007 Feb 22.
521 Differentiation of human embryonic stem cells into smooth muscle cells in adherent monolayer culture. Biochem Biophys Res Commun. 2006 Dec 15;351(2):321-7. doi: 10.1016/j.bbrc.2006.09.171. Epub 2006 Oct 17.
522 Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity. Toxicol Sci. 2011 Dec;124(2):278-90. doi: 10.1093/toxsci/kfr225. Epub 2011 Aug 27.
523 Programmed cell death-4 tumor suppressor protein contributes to retinoic acid-induced terminal granulocytic differentiation of human myeloid leukemia cells. Mol Cancer Res. 2007 Jan;5(1):95-108. doi: 10.1158/1541-7786.MCR-06-0125.
524 Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells. J Biol Chem. 2015 Jun 19;290(25):15799-15811. doi: 10.1074/jbc.M115.641167. Epub 2015 May 11.
525 Transcriptional responses to estrogen and progesterone in mammary gland identify networks regulating p53 activity. Endocrinology. 2008 Oct;149(10):4809-20. doi: 10.1210/en.2008-0035. Epub 2008 Jun 12.
526 Distinctive profiles of gene expression in the human nucleus accumbens associated with cocaine and heroin abuse. Neuropsychopharmacology. 2006 Oct;31(10):2304-12. doi: 10.1038/sj.npp.1301089. Epub 2006 May 3.
527 Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006 Jan 10;24(2):274-87. doi: 10.1200/JCO.2005.02.9405. Epub 2005 Dec 19.
528 Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst Biol. 2012 Dec 10;6:152.
529 Influence of Iron on Cytotoxicity and Gene Expression Profiles Induced by Arsenic in HepG2 Cells. Int J Environ Res Public Health. 2019 Nov 14;16(22):4484. doi: 10.3390/ijerph16224484.
530 Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
531 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
532 Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
533 Effects of progesterone treatment on expression of genes involved in uterine quiescence. Reprod Sci. 2011 Aug;18(8):781-97.
534 Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. Toxicol Lett. 2015 Jan 5;232(1):193-202. doi: 10.1016/j.toxlet.2014.10.009. Epub 2014 Oct 16.
535 Induction of PXR-mediated metabolism by beta-carotene. Biochim Biophys Acta. 2005 May 30;1740(2):162-9. doi: 10.1016/j.bbadis.2004.11.013. Epub 2004 Dec 8.
536 Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). Toxicol Appl Pharmacol. 2005 Dec 1;209(2):123-33. doi: 10.1016/j.taap.2005.03.015.
537 Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening. Drug Metab Dispos. 2011 Feb;39(2):337-44. doi: 10.1124/dmd.110.035808. Epub 2010 Nov 10.
538 Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor. Drug Metab Dispos. 2005 Jul;33(7):924-9.
539 Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor. Toxicol Lett. 2017 Jan 4;265:86-96.
540 Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells. Nucleic Acids Res. 2009 May;37(8):2584-95. doi: 10.1093/nar/gkp117. Epub 2009 Mar 5.
541 Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicol Sci. 2010 Dec; 118(2):485-500.
542 Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). Toxicol Sci. 2013 Dec;136(2):328-43.
543 Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals. Chem Res Toxicol. 2017 May 15;30(5):1219-1229. doi: 10.1021/acs.chemrestox.7b00048. Epub 2017 May 4.
544 A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicol Sci. 2013 Nov;136(1):216-41.
545 Small-scale immunopurification of cytochrome c oxidase for a high-throughput multiplexing analysis of enzyme activity and amount. Biotechnol Appl Biochem. 2007 Dec;48(Pt 4):167-78. doi: 10.1042/BA20060223.
546 An increase of cytochrome C oxidase mediated disruption of gemcitabine incorporation into DNA in a resistant KB clone. Biochem Pharmacol. 2007 Jun 15;73(12):1927-38. doi: 10.1016/j.bcp.2007.03.014. Epub 2007 Mar 20.
547 Resveratrol induces apoptosis and alters gene expression in human fibrosarcoma cells. Anticancer Res. 2015 Feb;35(2):767-74.
548 High-throughput data integration of RNA-miRNA-circRNA reveals novel insights into mechanisms of benzo[a]pyrene-induced carcinogenicity. Nucleic Acids Res. 2015 Mar 11;43(5):2525-34. doi: 10.1093/nar/gkv115. Epub 2015 Feb 17.
549 [Colchicine in chronic liver disease of alcoholic etiology. Double-blind, randomized study of its effects on blood levels of plasma proteins and clinical course in patients]. Rev Assoc Med Bras (1992). 1995 May-Jun;41(3):207-12.
550 Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin. Am J Respir Cell Mol Biol. 2004 May;30(5):662-70. doi: 10.1165/rcmb.2003-0267OC. Epub 2003 Nov 20.
551 Molecular characterization of a toxicological tipping point during human stem cell differentiation. Reprod Toxicol. 2020 Jan;91:1-13. doi: 10.1016/j.reprotox.2019.10.001. Epub 2019 Oct 7.
552 Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
553 Antithrombotic effects of aspirin based on PLA1/A2 glycoprotein IIIa polymorphism in patients with coronary artery disease. Thromb Res. 2007;119(3):301-3. doi: 10.1016/j.thromres.2006.03.005. Epub 2006 May 3.
554 Specificity of increased des-gamma-carboxyprothrombin in hepatocellular carcinoma after vitamin K1 injection. J Hepatol. 1987 Aug;5(1):27-9. doi: 10.1016/s0168-8278(87)80057-0.
555 Haemostatic effects of supraphysiological levels of testosterone in normal men. Thromb Haemost. 1995 Aug;74(2):693-7.
556 Atorvastatin and quinapril inhibit blood coagulation in patients with coronary artery disease following 28 days of therapy. J Thromb Haemost. 2006 Nov;4(11):2397-404. doi: 10.1111/j.1538-7836.2006.02165.x. Epub 2006 Aug 14.
557 Arsenic trioxide downregulates the expression of annexin II in bone marrow cells from patients with acute myelogenous leukemia. Chin Med J (Engl). 2009 Sep 5;122(17):1969-73.
558 Effect of clofibrate on plasma proteins including components of the hemostatic mechanism. Clin Chim Acta. 1976 Jan 2;66(1):9-17. doi: 10.1016/0009-8981(76)90366-1.
559 Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
560 Arsenic trioxide, retinoic acid and Ara-c regulated the expression of annexin II on the surface of APL cells, a novel co-receptor for plasminogen/tissue plasminogen activator. Thromb Res. 2002 Apr 1;106(1):63-70. doi: 10.1016/s0049-3848(02)00075-0.
561 Effects of histamine H2-receptor blockade on the cardiovascular reflex response to lower-body negative pressure in man. Acta Physiol Scand. 1990 May;139(1):161-72. doi: 10.1111/j.1748-1716.1990.tb08909.x.
562 Addition of acebutolol to diuretics in hypertension. Clin Pharmacol Ther. 1981 Dec;30(6):739-44. doi: 10.1038/clpt.1981.232.
563 Relative potency of a beta-blocking and a calcium entry blocking agent as antihypertensive drugs in black patients. Eur J Clin Pharmacol. 1986;29(5):523-7. doi: 10.1007/BF00635887.
564 Influences of norepinephrine transporter function on the distribution of sympathetic activity in humans. Hypertension. 2006 Jul;48(1):120-6. doi: 10.1161/01.HYP.0000225424.13138.5d. Epub 2006 May 22.
565 Effects of sulindac and naproxen on prostaglandin excretion in patients with impaired renal function and rheumatoid arthritis. Am J Med. 1990 Sep;89(3):313-21. doi: 10.1016/0002-9343(90)90344-d.
566 Effects of an angiotensin converting enzyme inhibitor, ramipril, on intracranial circulation in healthy volunteers. off. Br J Clin Pharmacol. 1992 Sep;34(3):224-30. doi: 10.1111/j.1365-2125.1992.tb04128.x.
567 Inhibition of cGMP-specific phosphodiesterase type 5 reduces sodium excretion and arterial blood pressure in patients with NaCl retention and ascites. Am J Physiol Renal Physiol. 2005 May;288(5):F1044-52. doi: 10.1152/ajprenal.00142.2004. Epub 2004 Dec 21.
568 beta-Endorphin and essential hypertension: importance of the clonidine-naloxone interaction. Acta Physiol Hung. 1985;65(2):217-26.
569 Hypokalemia from beta2-receptor stimulation by circulating epinephrine. N Engl J Med. 1983 Dec 8;309(23):1414-9. doi: 10.1056/NEJM198312083092303.
570 Detection of low-renin hypertension; evaluation of out-patient renin-stimulating methods. Clin Sci Mol Med. 1975 Feb;48(2):91-6. doi: 10.1042/cs0480091.
571 Carbon tetrachloride induced mitochondrial division, respiratory chain damage, abnormal intracellular [H(+)] and apoptosis are due to the activation of 5-HT degradation system in hepatocytes. Toxicol Appl Pharmacol. 2022 Mar 15;439:115929. doi: 10.1016/j.taap.2022.115929. Epub 2022 Feb 21.
572 Detection of gene expression alteration of myeloma cells treated with arsenic trioxide. Zhonghua Xue Ye Xue Za Zhi. 2005 Apr;26(4):209-13.
573 The identification of cellular targets of 17 estradiol using a lytic (T7) cDNA phage display approach. Toxicol In Vitro. 2011 Feb;25(1):388-93. doi: 10.1016/j.tiv.2010.10.012. Epub 2010 Oct 27.
574 Plasma proteinase inhibitor activity and hemostasis tests in children with nephrotic syndrome. Effect of prednisone alone and prednisone plus epsilon-aminocaproic acid treatment regimens: a preliminary report. Am J Ther. 2001 Mar-Apr;8(2):97-107. doi: 10.1097/00045391-200103000-00004.
575 Stress doses of hydrocortisone reduce severe systemic inflammatory response syndrome and improve early outcome in a risk group of patients after cardiac surgery. Crit Care Med. 2003 Apr;31(4):1068-74. doi: 10.1097/01.CCM.0000059646.89546.98.
576 Venous thrombosis, heparin-induced antithrombin III deficiency, and factor VIII. Lancet. 1977 Dec 10;2(8050):1231-2.
577 Steroid profiling in H295R cells to identify chemicals potentially disrupting the production of adrenal steroids. Toxicology. 2017 Apr 15;381:51-63.
578 Amiloride, spironolactone, and potassium chloride in thiazide-treated hypertensive patients. Clin Pharmacol Ther. 1980 Apr;27(4):533-43. doi: 10.1038/clpt.1980.75.
579 Simvastatin treatment in subjects at high cardiovascular risk modulates AT1R expression on circulating monocytes and T lymphocytes. J Hypertens. 2008 Jun;26(6):1147-55. doi: 10.1097/HJH.0b013e3282f97dde.
580 Effects of lisinopril on cardiorespiratory, neuroendocrine, and renal function in patients with asymptomatic left ventricular dysfunction. Br Heart J. 1993 Jun;69(6):512-5. doi: 10.1136/hrt.69.6.512.
581 Angiotensin II receptor blockade in normotensive subjects: A direct comparison of three AT1 receptor antagonists. Hypertension. 1999 Mar;33(3):850-5. doi: 10.1161/01.hyp.33.3.850.
582 Study of low-density lipoprotein receptor regulation by oral (steroid) contraceptives: desogestrel, levonorgestrel and ethinyl estradiol in JEG-3 cell line and placental tissue. Contraception. 2007 Oct;76(4):297-305. doi: 10.1016/j.contraception.2007.06.011. Epub 2007 Sep 14.
583 Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression. J Biol Chem. 2020 Nov 20;295(47):15870-15882. doi: 10.1074/jbc.RA120.015623. Epub 2020 Sep 10.
584 Differential regulation of apolipoprotein B secretion from HepG2 cells by two HMG-CoA reductase inhibitors, atorvastatin and simvastatin. J Lipid Res. 1999 Jun;40(6):1078-89.
585 Rapid-onset hypogonadism secondary to crizotinib use in men with metastatic nonsmall cell lung cancer. Cancer. 2012 Nov 1;118(21):5302-9. doi: 10.1002/cncr.27450. Epub 2012 Apr 4.
586 Suppression of spermatogenesis in patients with Beh?et's disease treated with cyclophosphamide and colchicine. Fertil Steril. 1981 Jul;36(1):76-80. doi: 10.1016/s0015-0282(16)45622-0.
587 [Kuntai capsule combined with gonadotropin releasing hormone agonist in treatment of moderate-severe endometriosis: a clinical observation]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014 Nov;34(11):1288-91.
588 Pharmacokinetics of new testosterone transdermal therapeutic systems in gonadotropin-releasing hormone antagonist-suppressed normal men. Exp Clin Endocrinol Diabetes. 1999;107(1):63-9. doi: 10.1055/s-0029-1212075.
589 Aromatase inhibition, testosterone, and seizures. Epilepsy Behav. 2004 Apr;5(2):260-3. doi: 10.1016/j.yebeh.2003.12.001.
590 Male sexual dysfunction during treatment with cimetidine. Br Med J. 1979 Mar 10;1(6164):659. doi: 10.1136/bmj.1.6164.659.
591 Effect of risperidone and olanzapine on reproductive hormones, psychopathology and sexual functioning in male patients with schizophrenia. Psychoneuroendocrinology. 2009 Jan;34(1):129-39. doi: 10.1016/j.psyneuen.2008.08.015. Epub 2008 Oct 5.
592 Chronic naltrexone treatment induces desensitization of the luteinizing hormone pulse generator for opioid blockade in hyperprolactinemic patients. J Clin Endocrinol Metab. 1995 May;80(5):1739-42. doi: 10.1210/jcem.80.5.7745028.
593 Erectile function and nocturnal penile tumescence in patients with prostate cancer undergoing luteinizing hormone-releasing hormone agonist therapy. Int J Urol. 1999 Jan;6(1):19-23. doi: 10.1046/j.1442-2042.1999.06128.x.
594 Relative progestational and androgenic activity of four progestins used for male hormonal contraception assessed in vitro in relation to their ability to suppress LH secretion in the castrate male rat. Mol Cell Endocrinol. 2010 Oct 26;328(1-2):16-21. doi: 10.1016/j.mce.2010.06.010. Epub 2010 Jun 25.
595 Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard. Arch Toxicol. 2021 Feb;95(2):727-747. doi: 10.1007/s00204-020-02946-5. Epub 2021 Jan 25.
596 Differences in the opioid control of luteinizing hormone secretion between pathological and iatrogenic hyperprolactinemic states. J Clin Endocrinol Metab. 1987 Mar;64(3):508-12. doi: 10.1210/jcem-64-3-508.
597 The effect of alprazolam on serum cortisol and luteinizing hormone pulsatility in normal women and in women with stress-related anovulation. J Clin Endocrinol Metab. 1995 Mar;80(3):818-23. doi: 10.1210/jcem.80.3.7883836.
598 Metal-catalyzed oxidation of human growth hormone: modulation by solvent-induced changes of protein conformation. J Pharm Sci. 2001 Jan;90(1):58-69. doi: 10.1002/1520-6017(200101)90:1<58::aid-jps7>3.0.co;2-w.
599 Assessment of MK-912, an alpha 2-adrenoceptor antagonist, with use of intravenous clonidine. Clin Pharmacol Ther. 1989 Jul;46(1):103-9. doi: 10.1038/clpt.1989.113.
600 Phosphatidylinositol 4-OH kinase is a downstream target of neuronal calcium sensor-1 in enhancing exocytosis in neuroendocrine cells. J Biol Chem. 2003 Feb 21;278(8):6075-84. doi: 10.1074/jbc.M204702200. Epub 2002 Dec 5.
601 [Toxicity of cyproheptadine. Side effects and accidental overdosage (author's transl)]. Monatsschr Kinderheilkd (1902). 1978 Mar;126(3):123-6.
602 Failure of gammahydroxy butyric acid to stimulate growth hormone secretion in cocaine addicts. Neuropeptides. 1997 Oct;31(5):459-62. doi: 10.1016/s0143-4179(97)90040-8.
603 Effect of centrally acting alpha-adrenergic agonists on sympathetic nervous system function in humans. Hypertension. 1984 Sep-Oct;6(5 Pt 2):II57-62. doi: 10.1161/01.hyp.6.5_pt_2.ii57.
604 Thyrotropin-releasing hormone-induced GH release after cocaine withdrawal in cocaine addicts. Neuropeptides. 1999 Dec;33(6):522-5. doi: 10.1054/npep.1999.0773.
605 Effects of cortisol and cocaine on plasma prolactin and growth hormone levels in cocaine-dependent volunteers. Addict Behav. 2005 May;30(4):859-64. doi: 10.1016/j.addbeh.2004.08.019.
606 Insulin-like growth factors (IGF) I and II utilize different calcium signaling pathways in a primary human parathyroid cell culture model. World J Surg. 2006 Mar;30(3):333-45. doi: 10.1007/s00268-005-0339-8.
607 Effect of aspirin on cell proliferation and differentiation of colon adenocarcinoma Caco-2 cells. Int J Cancer. 1997 Dec 10;73(6):880-4. doi: 10.1002/(sici)1097-0215(19971210)73:6<880::aid-ijc20>3.0.co;2-7.
608 Ethinylestradiol and testosterone have divergent effects on circulating IGF system components in adolescents with constitutional tall stature. Eur J Endocrinol. 2005 Apr;152(4):597-604. doi: 10.1530/eje.1.01880.
609 Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child. PLoS One. 2009 Nov 16;4(11):e7845. doi: 10.1371/journal.pone.0007845.
610 C-Reactive protein levels over time and cardiovascular risk in HIV-infected individuals suppressed on an indinavir-based regimen: AIDS Clinical Trials Group 5056s. AIDS. 2004 Dec 3;18(18):2434-7.
611 Simvastatin combined with ramipril treatment in hypercholesterolemic patients. Hypertension. 2004 Aug;44(2):180-5. doi: 10.1161/01.HYP.0000133310.42762.25. Epub 2004 Jun 7.
612 The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells. Eur J Pharmacol. 2007 Feb 28;557(2-3):221-9.
613 Inhibition of Bruton tyrosine kinase in patients with severe COVID-19. Sci Immunol. 2020 Jun 5;5(48):eabd0110. doi: 10.1126/sciimmunol.abd0110. Epub 2020 Jun 5.
614 The influence of alclofenac treatment on acute-phase proteins, plasma tryptophan, and erythrocyte sedimentation rate in patients with rheumatoid arthritis. Curr Med Res Opin. 1975;3(5):286-97. doi: 10.1185/03007997509114779.
615 Intractable insomnia after cessation of treatment with thalidomide. Gastroenterology. 2001 May;120(6):1567-8. doi: 10.1053/gast.2001.24495.
616 Effects of hormone treatment on hemostasis variables. Climacteric. 2007 Oct;10 Suppl 2:32-7. doi: 10.1080/13697130701598548.
617 Estrogen-like activity of metals in MCF-7 breast cancer cells. Endocrinology. 2003 Jun;144(6):2425-36. doi: 10.1210/en.2002-221054.
618 Cross-talk between non-genomic and genomic signalling pathways--distinct effect profiles of environmental estrogens. Toxicol Appl Pharmacol. 2010 Jun 1;245(2):160-70. doi: 10.1016/j.taap.2010.02.015. Epub 2010 Mar 4.
619 Bidirectional cross talk between ERalpha and EGFR signalling pathways regulates tamoxifen-resistant growth. Breast Cancer Res Treat. 2006 Mar;96(2):131-46. doi: 10.1007/s10549-005-9070-2. Epub 2005 Oct 27.
620 Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry. Odontology. 2013 Jan;101(1):43-51.
621 The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res. 2005 Jan 1;65(1):18-25.
622 Antitumoral activity of liraglutide, a new DNMT inhibitor in breast cancer cells in vitro and in vivo. Chem Biol Interact. 2021 Nov 1;349:109641. doi: 10.1016/j.cbi.2021.109641. Epub 2021 Sep 14.
623 Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells. Mol Pharmacol. 2001 Sep;60(3):595-602.
624 Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth. Br J Cancer. 2007 Apr 23;96(8):1204-15. doi: 10.1038/sj.bjc.6603705. Epub 2007 Mar 27.
625 Prediction of the combined effects of multiple estrogenic chemicals on MCF-7 human breast cancer cells and a preliminary molecular exploration of the estrogenic proliferative effects and related gene expression. Ecotoxicol Environ Saf. 2018 Sep 30;160:1-9. doi: 10.1016/j.ecoenv.2018.05.025. Epub 2018 May 21.
626 Resveratrol modulates the phosphoinositide 3-kinase pathway through an estrogen receptor alpha-dependent mechanism: relevance in cell proliferation. Int J Cancer. 2004 Mar 20;109(2):167-73. doi: 10.1002/ijc.11720.
627 Estrogenic activities of Ginkgo biloba extracts. Life Sci. 2004 Jan 30;74(11):1325-35. doi: 10.1016/j.lfs.2003.06.045.
628 Tartrazine and sunset yellow are xenoestrogens in a new screening assay to identify modulators of human oestrogen receptor transcriptional activity. Toxicology. 2012 Aug 16;298(1-3):40-51. doi: 10.1016/j.tox.2012.04.014. Epub 2012 May 3.
629 Co-culture of primary human mammary fibroblasts and MCF-7 cells as an in vitro breast cancer model. Toxicol Sci. 2005 Feb;83(2):257-63.
630 Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
631 Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells. Biol Pharm Bull. 2007 Feb;30(2):247-53. doi: 10.1248/bpb.30.247.
632 In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
633 Effects of olanzapine on serum protein phosphorylation patterns in patients with schizophrenia. Proteomics Clin Appl. 2015 Oct;9(9-10):907-16. doi: 10.1002/prca.201400148. Epub 2015 May 15.
634 Serum distribution of the major metabolites of norgestimate in relation to its pharmacological properties. Contraception. 2003 Feb;67(2):93-9. doi: 10.1016/s0010-7824(02)00473-0.
635 Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene. J Clin Invest. 2007 Dec;117(12):3979-87. doi: 10.1172/JCI32249.
636 Reproductive effects of valproate, carbamazepine, and oxcarbazepine in men with epilepsy. Neurology. 2001 Jan 9;56(1):31-6. doi: 10.1212/wnl.56.1.31.
637 Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and -fetoprotein. Toxicol Sci. 2015 Feb;143(2):333-48. doi: 10.1093/toxsci/kfu231. Epub 2014 Oct 27.
638 Testosterone or 17{beta}-estradiol exposure reveals sex-specific effects on glucose and lipid metabolism in human myotubes. J Endocrinol. 2011 Aug;210(2):219-29. doi: 10.1530/JOE-10-0497. Epub 2011 Jun 1.
639 p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
640 Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
641 Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
642 Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
643 Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
644 Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. Nucleic Acids Res. 2009 Jan;37(1):78-95. doi: 10.1093/nar/gkn910. Epub 2008 Nov 16.
645 Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
646 Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
647 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
648 Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
649 Thalidomide downregulates angiogenic genes in bone marrow endothelial cells of patients with active multiple myeloma. J Clin Oncol. 2005 Aug 10;23(23):5334-46. doi: 10.1200/JCO.2005.03.723. Epub 2005 Jun 6.
650 ?-adrenoceptors and muscarinic receptors mediate opposing effects on endothelin-1 expression in human lung fibroblasts. Eur J Pharmacol. 2012 Sep 15;691(1-3):218-24. doi: 10.1016/j.ejphar.2012.07.002. Epub 2012 Jul 13.
651 Induction of endothelin-1 expression by oxidative stress in vascular smooth muscle cells. Cardiovasc Pathol. 2001 Nov-Dec;10(6):311-5. doi: 10.1016/s1054-8807(01)00095-3.
652 [Effect of simvastatin on endothelin-1 expression in endothelial cell cultured hypoxically]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Jan;39(1):72-5.
653 Effects of dietary polyphenols on gene expression in human vascular endothelial cells. Proc Nutr Soc. 2008 Feb;67(1):42-7.
654 Nucleoside reverse transcriptase inhibitors induce a mitophagy-associated endothelial cytotoxicity that is reversed by coenzyme Q10 cotreatment. Toxicol Sci. 2013 Aug;134(2):323-34. doi: 10.1093/toxsci/kft105. Epub 2013 May 2.
655 Cardiac toxicity of high-dose cyclophosphamide in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation. Int J Hematol. 2007 Jun;85(5):408-14. doi: 10.1532/IJH97.E0620.
656 Different effects of angiotensin converting enzyme inhibitors on endothelin-1 and nitric oxide balance in human vascular endothelial cells: evidence of an oxidant-sensitive pathway. Mediators Inflamm. 2008;2008:305087. doi: 10.1155/2008/305087. Epub 2008 Dec 1.
657 High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells. Blood. 1993 Nov 15;82(10):3133-40.
658 Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples. Data Brief. 2016 Mar 26;7:1052-1057. doi: 10.1016/j.dib.2016.03.069. eCollection 2016 Jun.
659 Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
660 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
661 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
662 Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem. 2002 Nov 15;277(46):43648-58. doi: 10.1074/jbc.M203214200. Epub 2002 Sep 6.
663 [Regulation mechanism of autophagy-related protein LC3 by c-Jun in methotrexate resistant human choriocarcinoma JEG-3 cells]. Zhonghua Fu Chan Ke Za Zhi. 2014 Jul;49(7):531-5.
664 Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci. 2006 Jan;97(1):64-71.
665 Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells. Neoplasia. 2006 Sep;8(9):758-71.
666 Protein S levels are lower in women receiving desogestrel-containing combined oral contraceptives (COCs) than in women receiving levonorgestrel-containing COCs at steady state and on cross-over. Br J Haematol. 2001 Jun;113(4):898-904. doi: 10.1046/j.1365-2141.2001.02853.x.
667 Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth. Exp Cell Res. 2010 Aug 1;316(13):2174-88. doi: 10.1016/j.yexcr.2010.04.027. Epub 2010 May 8.
668 Quercetin augments TRAIL-induced apoptotic death: involvement of the ERK signal transduction pathway. Biochem Pharmacol. 2008 May 15;75(10):1946-58. doi: 10.1016/j.bcp.2008.02.016. Epub 2008 Mar 10.
669 Peroxisome proliferator-activated receptor-gamma ligands suppress fibronectin gene expression in human lung carcinoma cells: involvement of both CRE and Sp1. Am J Physiol Lung Cell Mol Physiol. 2005 Sep;289(3):L419-28. doi: 10.1152/ajplung.00002.2005. Epub 2005 May 20.
670 Mechanistic basis for overcoming platinum resistance using copper chelating agents. Mol Cancer Ther. 2012 Nov;11(11):2483-94. doi: 10.1158/1535-7163.MCT-12-0580. Epub 2012 Aug 21.
671 Regulation of the high-affinity copper transporter (hCtr1) expression by cisplatin and heavy metals. J Biol Inorg Chem. 2014 Jan;19(1):17-27. doi: 10.1007/s00775-013-1051-z. Epub 2013 Oct 17.
672 Thalidomide and a thalidomide analogue inhibit endothelial cell proliferation in vitro. J Neurooncol. 1999 Jun;43(2):109-14. doi: 10.1023/a:1006202700039.
673 The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription. Chem Biol Interact. 2014 Aug 5;219:123-32. doi: 10.1016/j.cbi.2014.05.019. Epub 2014 Jun 4.
674 Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci. 2007 Mar;96(1):101-14.
675 Vascular complications of long-term oestrogen therapy. Front Horm Res. 1977;5:174-91. doi: 10.1159/000401993.
676 Interaction between fenofibrate and warfarin. Ann Pharmacother. 1998 Jul-Aug;32(7-8):765-8. doi: 10.1345/aph.17310.
677 Effect of opium addiction on new and traditional cardiovascular risk factors: do duration of addiction and route of administration matter?. Lipids Health Dis. 2008 Nov 3;7:42. doi: 10.1186/1476-511X-7-42.
678 Metronomic gemcitabine suppresses tumour growth, improves perfusion, and reduces hypoxia in human pancreatic ductal adenocarcinoma. Br J Cancer. 2010 Jun 29;103(1):52-60.
679 Short-term effects of estrogen, tamoxifen and raloxifene on hemostasis: a randomized-controlled study and review of the literature. Thromb Res. 2005;116(1):1-13. doi: 10.1016/j.thromres.2004.09.014.
680 Investigation of in vitro odonto/osteogenic capacity of cannabidiol on human dental pulp cell. J Dent. 2021 Jun;109:103673. doi: 10.1016/j.jdent.2021.103673. Epub 2021 Apr 16.
681 Statin-mediated reduction of osteopontin expression induces apoptosis and cell growth arrest in ovarian clear cell carcinoma. Oncol Rep. 2011 Jan;25(1):41-7.
682 Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
683 Troglitazone, a PPARgamma ligand, inhibits osteopontin gene expression in human monocytes/macrophage THP-1 cells. J Atheroscler Thromb. 2000;7(2):77-82. doi: 10.5551/jat1994.7.77.
684 Azacytidine induces cell cycle arrest and suppression of neuroendocrine markers in carcinoids. Int J Clin Exp Med. 2010 Mar 28;3(2):95-102.
685 Resveratrol induces Notch2-mediated apoptosis and suppression of neuroendocrine markers in medullary thyroid cancer. Ann Surg Oncol. 2011 May;18(5):1506-11. doi: 10.1245/s10434-010-1488-z. Epub 2010 Dec 24.
686 ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
687 Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. Eur Rev Med Pharmacol Sci. 2016;20(6):1203-13.
688 Thalidomide alters c-MYB and PIM-1 signaling in K-562 cells. Pharmacol Res. 2006 Aug;54(2):91-6. doi: 10.1016/j.phrs.2006.02.010. Epub 2006 Mar 8.
689 Activation of PPAR and inhibition of cell proliferation reduces key proteins associated with the basal subtype of bladder cancer in As3+-transformed UROtsa cells. PLoS One. 2020 Aug 21;15(8):e0237976. doi: 10.1371/journal.pone.0237976. eCollection 2020.
690 Oral lichenoid eruption secondary to imatinib (Glivec). J Dermatolog Treat. 2004 Jul;15(4):253-5. doi: 10.1080/09546630410015556.
691 Retinoic acid receptor- and retinoid X receptor-selective retinoids activate signaling pathways that converge on AP-1 and inhibit squamous differentiation in human bronchial epithelial cells. Cell Growth Differ. 1996 Aug;7(8):997-1004.
692 Effects of aspirin on metastasis-associated gene expression detected by cDNA microarray. Acta Pharmacol Sin. 2004 Oct;25(10):1327-33.
693 Identification of estrogen-responsive genes by complementary deoxyribonucleic acid microarray and characterization of a novel early estrogen-induced gene: EEIG1. Mol Endocrinol. 2004 Feb;18(2):402-11. doi: 10.1210/me.2003-0202. Epub 2003 Nov 6.
694 Antitumor effect of aspirin in glioblastoma cells by modulation of -catenin/T-cell factor-mediated transcriptional activity. J Neurosurg. 2011 Oct;115(4):780-8. doi: 10.3171/2011.5.JNS113. Epub 2011 Jul 1.
695 Inhibition of estrogen receptor reduces connexin 43 expression in breast cancers. Toxicol Appl Pharmacol. 2018 Jan 1;338:182-190. doi: 10.1016/j.taap.2017.11.020. Epub 2017 Nov 24.
696 Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4578-83.
697 Reduced expression of endothelial connexins 43 and 37 in hypertensive rats is rectified after 7-day carvedilol treatment. Am J Hypertens. 2006 Feb;19(2):129-35. doi: 10.1016/j.amjhyper.2005.08.020.
698 Role of connexin 43 in cadmium-induced proliferation of human prostate epithelial cells. J Appl Toxicol. 2017 Aug;37(8):933-942. doi: 10.1002/jat.3441. Epub 2017 Feb 8.
699 Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
700 Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy. Mol Cancer Res. 2009 Feb;7(2):199-209. doi: 10.1158/1541-7786.MCR-08-0314. Epub 2009 Feb 10.
701 Effects of Imatinib Mesylate (Gleevec) on human islet NF-kappaB activation and chemokine production in vitro. PLoS One. 2011;6(9):e24831. doi: 10.1371/journal.pone.0024831. Epub 2011 Sep 14.
702 Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
703 Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
704 A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
705 The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
706 Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
707 Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
708 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
709 Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer. 2006 Mar 15;118(6):1370-80. doi: 10.1002/ijc.21537.
710 Estrogens exert route- and dose-dependent effects on insulin-like growth factor (IGF)-binding protein-3 and the acid-labile subunit of the IGF ternary complex. J Clin Endocrinol Metab. 2000 May;85(5):1918-22. doi: 10.1210/jcem.85.5.6527.
711 Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis. Biol Reprod. 2011 Apr;84(4):801-15.
712 Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Mol Pharm. 2015 Jan 5;12(1):171-8.
713 Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells. Mol Pharm. 2004 Jan 12;1(1):49-56.
714 Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters. Exp Hematol. 2011 Apr;39(4):446-56.
715 Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):86-96.
716 The SLCO1A2 gene, encoding human organic anion-transporting polypeptide 1A2, is transactivated by the vitamin D receptor. Mol Pharmacol. 2012 Jul;82(1):37-46. doi: 10.1124/mol.112.077909. Epub 2012 Apr 3.
717 Chemokine stromal cell-derived factor-1 induction by C/EBPbeta activation is associated with all-trans-retinoic acid-induced leukemic cell differentiation. J Leukoc Biol. 2007 Nov;82(5):1332-9. doi: 10.1189/jlb.1106697. Epub 2007 Jul 26.
718 Sevoflurane but not propofol enhances ovarian cancer cell biology through regulating cellular metabolic and signaling mechanisms. Cell Biol Toxicol. 2023 Aug;39(4):1395-1411. doi: 10.1007/s10565-022-09766-6. Epub 2022 Oct 8.
719 Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
720 Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
721 Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.
722 Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
723 Blood cell oxidative stress precedes hemolysis in whole blood-liver slice co-cultures of rat, dog, and human tissues. Toxicol Appl Pharmacol. 2010 May 1;244(3):354-65. doi: 10.1016/j.taap.2010.01.017. Epub 2010 Feb 6.
724 Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells. Biochem Biophys Res Commun. 2002 Feb 8;290(5):1427-33. doi: 10.1006/bbrc.2002.6367.
725 Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter. Free Radic Biol Med. 2002 Mar 1;32(5):386-93. doi: 10.1016/s0891-5849(01)00812-7.
726 Glycidamide and cis-2-butene-1,4-dial (BDA) as potential carcinogens and promoters of liver cancer - An in vitro study. Food Chem Toxicol. 2022 Aug;166:113251. doi: 10.1016/j.fct.2022.113251. Epub 2022 Jun 21.
727 Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line. Mol Cancer Ther. 2009 May;8(5):1197-206.
728 Gene expression profile changes in NB4 cells induced by arsenic trioxide. Acta Pharmacol Sin. 2003 Jul;24(7):646-50.
729 Astaxanthin protects mesenchymal stem cells from oxidative stress by direct scavenging of free radicals and modulation of cell signaling. Chem Biol Interact. 2021 Jan 5;333:109324. doi: 10.1016/j.cbi.2020.109324. Epub 2020 Nov 17.
730 Comparative effects of retinoic acid, vitamin D and resveratrol alone and in combination with adenosine analogues on methylation and expression of phosphatase and tensin homologue tumour suppressor gene in breast cancer cells. Br J Nutr. 2012 Mar;107(6):781-90. doi: 10.1017/S0007114511003631. Epub 2011 Aug 1.
731 Arsenic trioxide inhibits the proliferation of myeloma cell line through notch signaling pathway. Cancer Cell Int. 2013 Mar 13;13(1):25. doi: 10.1186/1475-2867-13-25.
732 Mechanism of thalidomide to enhance cytotoxicity of temozolomide in U251-MG glioma cells in vitro. Chin Med J (Engl). 2009 Jun 5;122(11):1260-6.
733 Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
734 Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells. Proteomics. 2004 Jul;4(7):2160-74.
735 Role of androgens in dhea-induced rack1 expression and cytokine modulation in monocytes. Immun Ageing. 2016 May 29;13:20. doi: 10.1186/s12979-016-0075-y. eCollection 2016.
736 The scaffold protein RACK1 is a target of endocrine disrupting chemicals (EDCs) with important implication in immunity. Toxicol Appl Pharmacol. 2017 Jun 15;325:37-47. doi: 10.1016/j.taap.2017.04.011. Epub 2017 Apr 13.
737 Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene. 2005 Feb 10;24(7):1231-43. doi: 10.1038/sj.onc.1208290.
738 In vitro antioxidant and antigenotoxic potentials of 3,5-O-di-galloylquinic acid extracted from Myrtus communis leaves and modulation of cell gene expression by H2O2. J Appl Toxicol. 2012 May;32(5):333-41.
739 HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage. FASEB J. 2005 Mar;19(3):476-8. doi: 10.1096/fj.04-2745fje. Epub 2004 Dec 29.
740 Amifostine impairs p53-mediated apoptosis of human myeloid leukemia cells. Mol Cancer Ther. 2003 Sep;2(9):893-900.
741 Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
742 Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
743 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
744 Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochem Pharmacol. 2011 Feb 15;81(4):510-7. doi: 10.1016/j.bcp.2010.11.014. Epub 2010 Nov 27.
745 Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c. Biochim Biophys Acta. 2010 Apr;1803(4):452-67. doi: 10.1016/j.bbamcr.2009.12.005. Epub 2010 Jan 4.
746 Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
747 The methyl transferase PRMT1 functions as co-activator of farnesoid X receptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes. Mol Pharmacol. 2005 Aug;68(2):551-8. doi: 10.1124/mol.105.012104. Epub 2005 May 23.
748 Dysregulation of retinoic acid receptor diminishes hepatocyte permissiveness to hepatitis B virus infection through modulation of sodium taurocholate cotransporting polypeptide (NTCP) expression. J Biol Chem. 2015 Feb 27;290(9):5673-84. doi: 10.1074/jbc.M114.602540. Epub 2014 Dec 30.
749 Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes. Drug Metab Dispos. 2006 Oct;34(10):1756-63. doi: 10.1124/dmd.106.010033. Epub 2006 Jul 12.
750 Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures. Toxicol Sci. 2014 Oct;141(2):538-46. doi: 10.1093/toxsci/kfu151. Epub 2014 Jul 23.
751 Regulation of hepatic drug transporter activity and expression by organochlorine pesticides. J Biochem Mol Toxicol. 2014 Mar;28(3):119-28.
752 Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways. Pharm Res. 2009 Apr;26(4):872-82.
753 Fetal bovine serum and human constitutive androstane receptor: evidence for activation of the SV23 splice variant by artemisinin, artemether, and arteether in a serum-free cell culture system. Toxicol Appl Pharmacol. 2014 Jun 1;277(2):221-30. doi: 10.1016/j.taap.2014.03.023. Epub 2014 Apr 12.
754 Constitutive androstane/active receptor is a target of retinoic acid receptor in humans. Biochem Pharmacol. 2010 Jul 1;80(1):129-35. doi: 10.1016/j.bcp.2010.02.023. Epub 2010 Mar 6.
755 Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay. Toxicol In Vitro. 2018 Feb;46:335-349. doi: 10.1016/j.tiv.2017.09.014. Epub 2017 Sep 18.
756 Teriflunomide is an indirect human constitutive androstane receptor (CAR) activator interacting with epidermal growth factor (EGF) signaling. Front Pharmacol. 2018 Oct 11;9:993.
757 Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2716-23.
758 Trientine reduces BACE1 activity and mitigates amyloidosis via the AGE/RAGE/NF-B pathway in a transgenic mouse model of Alzheimer's disease. Antioxid Redox Signal. 2013 Dec 10;19(17):2024-39. doi: 10.1089/ars.2012.5158. Epub 2013 May 3.
759 Prediction of drug-induced liver injury using keratinocytes. J Appl Toxicol. 2017 Jul;37(7):863-872. doi: 10.1002/jat.3435. Epub 2017 Jan 31.
760 Development of a cell-based assay system considering drug metabolism and immune- and inflammatory-related factors for the risk assessment of drug-induced liver injury. Toxicol Lett. 2014 Jul 3;228(1):13-24. doi: 10.1016/j.toxlet.2014.04.005. Epub 2014 Apr 15.
761 The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
762 Using a customized DNA microarray for expression profiling of the estrogen-responsive genes to evaluate estrogen activity among natural estrogens and industrial chemicals. Environ Health Perspect. 2004 May;112(7):773-81. doi: 10.1289/ehp.6753.
763 Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. BMC Genomics. 2006 Apr 3;7:68. doi: 10.1186/1471-2164-7-68.
764 Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
765 Cardiac toxicity from ethanol exposure in human-induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci. 2019 May 1;169(1):280-292.
766 Cigarette smoke affects keratinocytes SRB1 expression and localization via H2O2 production and HNE protein adducts formation. PLoS One. 2012;7(3):e33592. doi: 10.1371/journal.pone.0033592. Epub 2012 Mar 19.
767 Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells. J Immunol. 2008 Nov 15;181(10):7332-40. doi: 10.4049/jimmunol.181.10.7332.
768 Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding. PLoS One. 2012;7(4):e35895. doi: 10.1371/journal.pone.0035895. Epub 2012 Apr 23.
769 Pregnane X receptor-agonists down-regulate hepatic ATP-binding cassette transporter A1 and scavenger receptor class B type I. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1533-41. doi: 10.1016/j.bbrc.2005.04.071.
770 Stimulation of CD36 and the key effector of reverse cholesterol transport ATP-binding cassette A1 in monocytoid cells by niacin. Biochem Pharmacol. 2004 Feb 1;67(3):411-9. doi: 10.1016/j.bcp.2003.09.014.
771 Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in Caco-2 cells treated with ezetimibe. J Nutr. 2005 Oct;135(10):2305-12. doi: 10.1093/jn/135.10.2305.
772 Stonin 2 activates lysosomal-mTOR axis for cell survival in oral cancer. Toxicol In Vitro. 2023 Apr;88:105561. doi: 10.1016/j.tiv.2023.105561. Epub 2023 Jan 23.
773 Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1) expression: role of chelatable iron. J Biol Chem. 2011 Dec 2;286(48):41413-41424. doi: 10.1074/jbc.M111.287052. Epub 2011 Oct 5.
774 Differential gene expression of sulindac-treated human breast epithelial cells. Int J Oncol. 2005 Dec;27(6):1727-36.
775 Combined tamoxifen and gefitinib in non-small cell lung cancer shows antiproliferative effects. Biomed Pharmacother. 2010 Feb;64(2):88-92. doi: 10.1016/j.biopha.2009.06.010. Epub 2009 Oct 23.
776 Quercetin exerts bidirectional regulation effects on the efficacy of tamoxifen in estrogen receptor-positive breast cancer therapy: An in vitro study. Environ Toxicol. 2020 Nov;35(11):1179-1193. doi: 10.1002/tox.22983. Epub 2020 Jun 12.
777 Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens, phytoestrogens and xenoestrogens. Toxicology. 2001 Sep 14;166(1-2):79-89. doi: 10.1016/s0300-483x(01)00437-1.
778 Estrogenic effects of natural and synthetic compounds including tibolone assessed in Saccharomyces cerevisiae expressing the human estrogen alpha and beta receptors. FASEB J. 2006 Jul;20(9):1552-4. doi: 10.1096/fj.05-5413fje. Epub 2006 May 23.
779 Comparison of relative binding affinities to fish and mammalian estrogen receptors: the regulatory implications. Toxicol Lett. 2010 Feb 15;192(3):298-315. doi: 10.1016/j.toxlet.2009.11.004. Epub 2009 Nov 12.
780 Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ Health Perspect. 2004 Apr;112(5):524-31. doi: 10.1289/ehp.6649.
781 Valproic acid and its derivatives enhanced estrogenic activity but not androgenic activity in a structure dependent manner. Reprod Toxicol. 2013 Dec;42:49-57. doi: 10.1016/j.reprotox.2013.07.019. Epub 2013 Jul 26.
782 Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. Biosci Biotechnol Biochem. 2002 Jul;66(7):1479-87. doi: 10.1271/bbb.66.1479.
783 Arylpiperazines for management of benign prostatic hyperplasia: design, synthesis, quantitative structure-activity relationships, and pharmacokinetic studies. J Med Chem. 2011 Jan 13;54(1):302-11. doi: 10.1021/jm101163m. Epub 2010 Dec 3.
784 Functional defect caused by the 4544G>A SNP in ABCC2: potential impact for drug cellular disposition. Pharmacogenet Genomics. 2011 Dec;21(12):884-93. doi: 10.1097/FPC.0b013e32834d672b.
785 Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione S-transferase A1-1-mediated resistance to chlorambucil cytotoxicity. J Pharmacol Exp Ther. 2004 Jan;308(1):260-7. doi: 10.1124/jpet.103.057729. Epub 2003 Oct 20.
786 MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid. Int J Cancer. 2005 Sep 20;116(5):824-9. doi: 10.1002/ijc.21013.
787 Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia. Cancer Sci. 2008 May;99(5):967-72.
788 Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis. Arthritis Rheum. 2013 Nov;65(11):2791-802.
789 In vitro study of transporters involved in intestinal absorption of inorganic arsenic. Chem Res Toxicol. 2012 Feb 20;25(2):446-53. doi: 10.1021/tx200491f. Epub 2012 Jan 26.
790 Co-encapsulation of chrysophsin-1 and epirubicin in PEGylated liposomes circumvents multidrug resistance in HeLa cells. Chem Biol Interact. 2015 Dec 5;242:13-23. doi: 10.1016/j.cbi.2015.08.023. Epub 2015 Sep 1.
791 Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma. Head Neck. 2011 Jul;33(7):959-68. doi: 10.1002/hed.21559. Epub 2010 Aug 24.
792 Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. Med Oncol. 2010 Sep;27(3):833-42. doi: 10.1007/s12032-009-9294-9. Epub 2009 Sep 10.
793 In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
794 Adaptive changes in global gene expression profile of lung carcinoma A549 cells acutely exposed to distinct types of AhR ligands. Toxicol Lett. 2018 Aug;292:162-174.
795 Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Sci Rep. 2014 Sep 26;4:6437. doi: 10.1038/srep06437.
796 The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution. Am J Physiol Regul Integr Comp Physiol. 2007 Sep;293(3):R1400-9. doi: 10.1152/ajpregu.00781.2006. Epub 2007 Jun 13.
797 Investigation of imatinib and other approved drugs as starting points for antidiabetic drug discovery with FXR modulating activity. Biochem Pharmacol. 2012 Jun 15;83(12):1674-81. doi: 10.1016/j.bcp.2012.02.027. Epub 2012 Mar 7.
798 Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells. Lipids Health Dis. 2010 Jun 2;9:56. doi: 10.1186/1476-511X-9-56.
799 Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
800 Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
801 Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of Captopril in women. Clin Pharmacol Ther. 2007 Aug;82(2):187-96. doi: 10.1038/sj.clpt.6100214. Epub 2007 May 2.
802 High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells. Br J Nutr. 2008 Apr;99(4):703-8.
803 Role of oxidative stress in the induction of metallothionein-2A and heme oxygenase-1 gene expression by the antineoplastic agent gallium nitrate in human lymphoma cells. Free Radic Biol Med. 2008 Sep 15;45(6):763-72.
804 Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
805 A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. Cutan Ocul Toxicol. 2010 Sep;29(3):171-92.
806 Actinomycin D inhibits the expression of the cystine/glutamate transporter xCT via attenuation of CD133 synthesis in CD133(+) HCC. Chem Biol Interact. 2019 Aug 25;309:108713. doi: 10.1016/j.cbi.2019.06.026. Epub 2019 Jun 19.
807 Steroidogenic gene expression in H295R cells and the human adrenal gland: adrenotoxic effects of lindane in vitro. J Appl Toxicol. 2006 Nov-Dec;26(6):484-92.
808 Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate. J Endocrinol. 2001 Dec;171(3):525-32.
809 Enzymatic characterization and interspecies difference of phenol sulfotransferases, ST1A forms. Drug Metab Dispos. 2001 Mar;29(3):274-81.
810 Sulfation of benzyl alcohol by the human cytosolic sulfotransferases (SULTs): a systematic analysis. J Appl Toxicol. 2016 Sep;36(9):1090-4.
811 Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis. Biochem Pharmacol. 2009 Apr 15;77(8):1410-7.
812 Drug sensitivity and drug resistance profiles of human intrahepatic cholangiocarcinoma cell lines. World J Gastroenterol. 2005 May 14;11(18):2748-53. doi: 10.3748/wjg.v11.i18.2748.
813 Adaptive homeostasis of the vitamin D-vitamin D nuclear receptor axis in 8-methoxypsoralen-induced hepatotoxicity. Toxicol Appl Pharmacol. 2019 Jan 1;362:150-158. doi: 10.1016/j.taap.2018.11.002. Epub 2018 Nov 10.
814 Differential regulation of the human MRP2 and MRP3 gene expression by glucocorticoids. J Steroid Biochem Mol Biol. 2005 Aug;96(3-4):229-34. doi: 10.1016/j.jsbmb.2005.03.004.
815 Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells. Mol Pharmacol. 2008 Aug;74(2):476-84.
816 Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor. J Steroid Biochem Mol Biol. 2016 Oct;163:77-87.
817 Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes. Life Sci. 2016 Jul 1;156:47-56.
818 Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol Toxicol. 2012 Apr;28(2):69-87.
819 Studies on sulfation of synthesized metabolites from the local anesthetics ropivacaine and lidocaine using human cloned sulfotransferases. Drug Metab Dispos. 1999 Sep;27(9):1057-63.
820 Sulfation of environmental estrogen-like chemicals by human cytosolic sulfotransferases. Biochem Biophys Res Commun. 2000 Jan 7;267(1):80-4. doi: 10.1006/bbrc.1999.1935.
821 Effect of all-trans retinoic acid on sodium/iodide symporter expression, radioiodine uptake and gene expression profiles in a human anaplastic thyroid carcinoma cell line. Nucl Med Biol. 2006 Oct;33(7):875-82. doi: 10.1016/j.nucmedbio.2006.07.004.
822 Megadose vitamin C suppresses sulfoconjugation in human colon carcinoma cell line Caco-2. Toxicol In Vitro. 2011 Mar;25(2):500-4.
823 In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions. Basic Clin Pharmacol Toxicol. 2008 Aug;103(2):157-65.
824 Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.
825 Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):843-52.
826 Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor. Drug Metab Dispos. 2003 Nov;31(11):1352-60.
827 Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. J Med Chem. 2005 Jun 2;48(11):3808-15.
828 Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21737-42. doi: 10.1073/pnas.1007863107. Epub 2010 Nov 22.
829 Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer Manag Res. 2009 Apr 3;1:25-37.
830 Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes. Chem Biol Interact. 2016 Aug 5;255:31-44.
831 Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR. Yakugaku Zasshi. 2002 May;122(5):339-61.
832 Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor. Chem Res Toxicol. 2014 Feb 17;27(2):304-308.
833 Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin. J Biol Chem. 2004 Jul 9;279(28):29295-301. doi: 10.1074/jbc.M400580200. Epub 2004 Apr 28.
834 Identification of novel agonists by high-throughput screening and molecular modelling of human constitutive androstane receptor isoform 3. Arch Toxicol. 2019 Aug;93(8):2247-2264. doi: 10.1007/s00204-019-02495-6. Epub 2019 Jul 16.
835 Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor. Mol Pharmacol. 2005 Jun;67(6):1954-65.
836 Characterization of human cytochrome P450 induction by pesticides. Toxicology. 2012 Mar 29;294(1):17-26.
837 Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. Arch Biochem Biophys. 2005 Feb 1;434(1):75-85.
838 Pyrethroids: cytotoxicity and induction of CYP isoforms in human hepatocytes. Drug Metabol Drug Interact. 2008;23(3-4):211-36.
839 Contribution of CYP3A5 to hepatic and renal ifosfamide N-dechloroethylation. Drug Metab Dispos. 2005 Jul;33(7):1074-81. doi: 10.1124/dmd.104.002279. Epub 2005 Apr 8.
840 Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity. J Toxicol Sci. 2017;42(3):343-348.
841 Induction of hepatic CYP3A enzymes by pregnancy-related hormones: studies in human hepatocytes and hepatic cell lines. Drug Metab Dispos. 2013 Feb;41(2):281-90.