Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFC71L)

• Drug Name: Clozapine Drug Info
• Synonyms: Asaleptin; CLOZARIL; Clorazil; Clozapin; Clozapina; Clozapinum; Fazaclo; Iprox; Leponex; Lepotex; Fazaclo ODT; C 6305; HF1854; Clopine (TN); Clozapina [INN-Spanish]; Clozapine(tautomer); Clozapinum [INN-Latin]; Clozaril (TN); Denzapine (TN); Fazaclo (TN); Froidir (TN); HF-1854; KS-1166; Klozapol (TN); LEX-123; LX 100-129; Leponex (TN); W-801; Zaponex (TN); Clozapine [USAN:INN:BAN]; Clozapine (JAN/USP/INN); 3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine; 8-Chloro-11-(4-methyl)-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine; 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo (b,e)(1,4)diazepine; 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine; 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine; 8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine; 8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine

Indication

Disease Entry	ICD 11	Status	REF
Schizophrenia	6A20	Approved	[1]
Treatment-refractory schizophrenia		Investigative	[2]

• Therapeutic Class: Antipsychotic Agents
• Cross-matching ID:
  PubChem CID: 135398737
  ChEBI ID: CHEBI:3766
  CAS Number: CAS 5786-21-0
  TTD Drug ID: DMFC71L
  VARIDT Drug ID: DR00474
  INTEDE Drug ID: DR0363
  ACDINA Drug ID: D00145

Molecule-Related Drug Atlas

Drug(s) Targeting Dopamine D4 receptor (D4R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenyltoloxamine	DMKAEQW	Allergy	4A80-4A85	Approved	[14]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[15]
RP5063	DMKUE8O	Schizophrenia	6A20	Phase 2	[16]
L-745,870	DMTGR25	Psychotic disorder	6A20-6A25	Phase 2	[17]
NGD 94-1	DMM1Y8F	Schizophrenia	6A20	Phase 1	[18]
ABT-724	DMDQVY4	Erectile dysfunction	HA01.1	Discontinued in Phase 2	[19]
Lu-35138	DMQ7A35	Psychotic disorder	6A20-6A25	Discontinued in Phase 2	[20]
NGD-94-4	DMZ9WLO	Schizophrenia	6A20	Discontinued in Phase 1	[21]
PD-165167	DMD0GB4	Schizophrenia	6A20	Preclinical	[18]
SPI-376	DMC1WAJ	Schizophrenia	6A20	Preclinical	[18]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[22]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[23]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[25]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[26]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[27]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[28]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[29]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[30]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[31]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[33]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[35]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[36]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[30]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[37]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[38]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[39]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[40]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[42]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[35]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[44]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[45]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[46]

Drug(s) Metabolized By Cytochrome P450 2A6 (CYP2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[38]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[47]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[48]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[33]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Metronidazole	DMTIVEN	Abscess		Approved	[50]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[51]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[53]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[54]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[55]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[33]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[37]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[56]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[57]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[58]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[59]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[60]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[61]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[47]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[62]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[63]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[64]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[61]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[65]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[51]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[66]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[47]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[47]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[70]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[71]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]

Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[74]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[66]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[75]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[76]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[47]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[77]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[79]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[51]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[80]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[81]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[82]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[83]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[84]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[85]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[86]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[87]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[88]
Levetiracetam	DMTGDN8	Epilepsy	8A60-8A68	Approved	[83]

Drug(s) Affected By D(4) dopamine receptor (DRD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[91]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Methamphetamine	DMPM4SK	Anxiety		Approved	[94]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[95]
Droperidol	DM0DXA8	Nausea	MD90	Approved	[96]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[96]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[96]

Drug(s) Affected By D(3) dopamine receptor (DRD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[97]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[98]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[99]
Methamphetamine	DMPM4SK	Anxiety		Approved	[100]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[101]
Droperidol	DM0DXA8	Nausea	MD90	Approved	[96]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[96]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[96]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[96]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[96]

Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (GNB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[99]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[103]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[105]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[106]
Sibutramine	DMFJTDI	Obesity	5B81	Approved	[107]
Almogran	DM7I64Z	Migraine	8A80	Approved	[108]
Eletriptan	DMW649X	Migraine	8A80	Approved	[108]

Drug(s) Affected By D(2) dopamine receptor (DRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Droperidol	DM0DXA8	Nausea	MD90	Approved	[96]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[96]
Zuclopenthixol	DMKYD5N	Schizophrenia	6A20	Approved	[96]
Meglitinides	DM1OFHN	Type-2 diabetes	5A11	Approved	[109]
Sulpiride	DMF54ZG	Schizophrenia	6A20	Approved	[110]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[111]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[112]
Methamphetamine	DMPM4SK	Anxiety		Approved	[113]
Bromocriptine	DMVE3TK	Acromegaly	5A60.0	Approved	[114]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[115]

Drug(s) Affected By Nuclear protein 1 (NUPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[116]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[117]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[118]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[119]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[117]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[118]

Drug(s) Affected By Alpha-1-antichymotrypsin (SERPINA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[119]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[117]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[117]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[123]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[124]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[117]

Drug(s) Affected By Serine protease hepsin (HPN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[117]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[117]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[117]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[118]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[117]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]

Drug(s) Affected By Fatty acid-binding protein, liver (FABP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[119]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[118]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[117]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[132]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[117]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[133]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[134]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[118]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[137]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[117]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[119]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]

Drug(s) Affected By Lanosterol synthase (LSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[117]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[141]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[117]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[117]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[142]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[143]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[118]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[117]

Drug(s) Affected By Inhibin beta E chain (INHBE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[117]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[119]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[117]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[143]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[118]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[117]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]

Drug(s) Affected By Transgelin (TAGLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[119]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[146]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[147]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[119]

Drug(s) Affected By Acid ceramidase (ASAH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[117]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[148]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[118]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[117]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[118]

Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[151]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[117]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[141]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[117]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[118]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[117]

Drug(s) Affected By Lysophospholipase D GDPD3 (GDPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[117]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[119]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[117]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[118]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[118]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[117]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[155]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]
Haloperidol	DM96SE0	Delirium		Approved	[118]

Drug(s) Affected By Fibronectin type III domain-containing protein 4 (FNDC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[117]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[117]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[117]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[117]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[118]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[117]
Haloperidol	DM96SE0	Delirium		Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[117]

Drug(s) Affected By Protein DEPP1 (DEPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[117]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[118]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[157]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[117]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[118]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[118]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[141]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[159]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[159]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[123]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[159]
Fructose	DM43AN2	Vomiting	MD90	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[159]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[162]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[163]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[164]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[96]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[167]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[142]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[168]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[169]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[166]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[170]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[172]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[142]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[173]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[159]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[172]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[159]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[142]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]

Drug(s) Affected By Lathosterol oxidase (SC5D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[167]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[175]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[176]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Haloperidol	DM96SE0	Delirium		Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[179]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[180]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[163]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[142]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[175]

Drug(s) Affected By Farnesyl pyrophosphate synthase (FDPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[142]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[175]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]

Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[96]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[148]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[141]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[189]

Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[96]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[190]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[192]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[171]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]

Drug(s) Affected By Acetyl-CoA acetyltransferase, cytosolic (ACAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[175]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[195]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[196]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[197]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[198]

Drug(s) Affected By 7-dehydrocholesterol reductase (DHCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[167]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[175]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[200]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[201]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[126]

Drug(s) Affected By AP-1 complex subunit sigma-1A (AP1S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[117]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[203]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[119]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[205]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[206]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[207]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Selenium	DM25CGV	N. A.	N. A.	Approved	[209]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[210]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[211]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[212]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[213]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[214]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[214]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[215]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[217]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[218]

Drug(s) Affected By Uncharacterized protein CXorf49 (CXORF49)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]

Drug(s) Affected By Cytosolic acyl coenzyme A thioester hydrolase (ACOT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[220]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[221]
Bortezomib	DMNO38U	Leukemia		Approved	[222]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[224]

Drug(s) Affected By AP-3 complex subunit beta-1 (AP3B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[152]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[152]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[225]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[226]

Drug(s) Affected By Galectin-8 (LGALS8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[228]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[195]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[91]
Bortezomib	DMNO38U	Leukemia		Approved	[222]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 14 (PSMD14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[229]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[132]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[230]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[132]

Drug(s) Affected By Syntenin-1 (SDCBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[231]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[195]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[232]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[233]

Drug(s) Affected By Importin subunit alpha-3 (KPNA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[234]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]

Drug(s) Affected By Dihydropyrimidinase-related protein 4 (DPYSL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[236]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[198]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[236]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]

Drug(s) Affected By CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[237]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[239]

Drug(s) Affected By Serine palmitoyltransferase 1 (SPTLC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[241]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[242]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[239]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[244]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[245]

Drug(s) Affected By Cytoplasmic dynein 1 light intermediate chain 2 (DYNC1LI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[246]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[248]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[161]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF13 (RNF13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[229]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[250]

Drug(s) Affected By Calumenin (CALU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[251]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]

Drug(s) Affected By Kinesin heavy chain isoform 5C (KIF5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[126]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[252]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[253]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[254]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[255]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[257]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[232]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[258]

Drug(s) Affected By Tetraspanin-3 (TSPAN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[259]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[260]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]

Drug(s) Affected By Eukaryotic translation initiation factor 5B (EIF5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[263]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[265]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[266]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[267]

Drug(s) Affected By U5 small nuclear ribonucleoprotein 200 kDa helicase (SNRNP200)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[232]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[161]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[266]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit J (EIF3J)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[263]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]

Drug(s) Affected By Glutaredoxin-3 (GLRX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[222]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[268]

Drug(s) Affected By Pre-mRNA-processing factor 6 (PRPF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Bortezomib	DMNO38U	Leukemia		Approved	[222]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[244]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[269]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[125]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[270]

Drug(s) Affected By Protein transport protein Sec31A (SEC31A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[246]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[201]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[268]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[271]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 15 (TNFSF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[272]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[273]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[196]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[274]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[275]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[276]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[277]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[277]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[278]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[276]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[277]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[279]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[276]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[280]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[276]

Drug(s) Affected By Structural maintenance of chromosomes protein 2 (SMC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[281]

Drug(s) Affected By Neuroendocrine secretory protein 55 (GNAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[282]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[283]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[284]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[285]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[286]
Haloperidol	DM96SE0	Delirium		Approved	[96]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[148]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[287]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[288]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[289]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[290]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[291]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[292]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[293]

Drug(s) Affected By Adenylate kinase isoenzyme 1 (AK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[96]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[96]
Anastrozole	DMNP60F	Breast cancer	2C60-2C65	Approved	[96]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[96]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]

Drug(s) Affected By Argininosuccinate synthase (ASS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[231]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[256]

Drug(s) Affected By Prolactin (PRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[295]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[296]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[297]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[298]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[299]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[300]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[301]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[302]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[303]

Drug(s) Affected By Insulin (INS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[304]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[305]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[306]
Fructose	DM43AN2	Vomiting	MD90	Approved	[307]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[308]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[309]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[310]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[311]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[312]

Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[313]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[314]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[315]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[316]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[317]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[318]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[319]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[320]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[321]

Drug(s) Affected By Interleukin-2 receptor subunit alpha (IL2RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[317]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[322]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[323]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[324]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[325]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[326]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[327]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[99]

Drug(s) Affected By Myelin basic protein (MBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[328]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[257]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[329]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[198]
Bortezomib	DMNO38U	Leukemia		Approved	[222]

Drug(s) Affected By C-reactive protein (CRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[96]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[330]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[331]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[332]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[142]
Acalabrutinib	DM7GCVW	leukaemia	2A60-2B33	Approved	[333]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[334]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[335]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[336]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[96]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[337]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[338]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[339]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[166]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[340]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[341]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[342]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[343]

Drug(s) Affected By C-X-C motif chemokine 10 (CXCL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[314]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[344]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[345]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[347]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[348]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]

Drug(s) Affected By Vitamin K-dependent protein C (PROC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[349]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[350]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[143]
Clomipramine	DMINRKW	Depression	6A70-6A7Z	Approved	[351]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[352]

Drug(s) Affected By Annexin A1 (ANXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[353]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[354]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[355]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[155]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[356]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[357]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]

Drug(s) Affected By Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[358]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[359]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[360]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[361]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[273]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[362]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[363]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[364]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[365]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[366]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[367]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[368]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[369]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[370]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[371]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[372]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[373]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[374]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[375]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[345]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[376]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[377]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[378]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[379]

Drug(s) Affected By Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (RPN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[230]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[380]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[381]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[382]

Drug(s) Affected By Insulin-like growth factor I (IGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[383]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[384]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[385]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[386]

Drug(s) Affected By Fructose-bisphosphate aldolase B (ALDOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[142]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[143]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[278]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[387]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[254]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[127]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[388]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[389]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[390]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[391]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[392]

Drug(s) Affected By Interleukin-5 (IL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[314]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[393]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[394]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[395]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[396]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[397]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[398]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[399]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[400]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[401]

Drug(s) Affected By Myeloperoxidase (MPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[96]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[96]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[402]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[403]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[404]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[405]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[406]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[407]

Drug(s) Affected By Myosin light chain 1/3, skeletal muscle isoform (MYL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[408]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[275]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[410]

Drug(s) Affected By Prothymosin alpha (PTMA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[411]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[412]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[356]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[256]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[413]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]

Drug(s) Affected By Glucose-6-phosphate isomerase (GPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[355]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[361]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]

Drug(s) Affected By Corticoliberin (CRH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Meglitinides	DM1OFHN	Type-2 diabetes	5A11	Approved	[414]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[414]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[414]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[415]
Haloperidol	DM96SE0	Delirium		Approved	[414]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Terbutaline	DMD4381	Asthma	CA23	Approved	[416]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[197]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[414]

Drug(s) Affected By Annexin A6 (ANXA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[198]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[417]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[418]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[419]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[420]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[420]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[421]

Drug(s) Affected By Annexin A5 (ANXA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[422]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[345]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[377]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[273]

Drug(s) Affected By Insulin-like growth factor-binding protein 1 (IGFBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[152]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[423]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[143]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[424]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[425]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]

Drug(s) Affected By CD63 antigen (CD63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[195]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[426]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[427]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[428]

Drug(s) Affected By Matrilysin (MMP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[212]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[429]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[430]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[252]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[431]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[432]

Drug(s) Affected By Stromelysin-2 (MMP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[127]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[116]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[134]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[433]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[134]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[124]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Haloperidol	DM96SE0	Delirium		Approved	[10]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[116]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Selenium	DM25CGV	N. A.	N. A.	Approved	[434]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[123]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[134]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[124]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[435]

Drug(s) Affected By Dihydropteridine reductase (QDPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[436]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[437]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[418]

Drug(s) Affected By 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[354]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[329]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[283]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]

Drug(s) Affected By Leukotriene A-4 hydrolase (LTA4H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[438]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[439]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[440]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[441]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[206]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[442]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[157]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[443]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[288]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[444]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[443]

Drug(s) Affected By Osteopontin (SPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[445]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[446]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[447]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[448]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[449]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[450]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[391]

Drug(s) Affected By Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (DLAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[329]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[198]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[438]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[438]

Drug(s) Affected By Myosin-3 (MYH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[256]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[267]

Drug(s) Affected By Muscarinic acetylcholine receptor M1 (CHRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pirenzepine	DMP6M1N	Peptic ulcer	DA61	Approved	[451]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[96]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[452]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[453]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[454]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[455]
Gallamine Triethiodide	DMPO0MS	Stabilize muscle contraction	FB3Z	Approved	[456]
Carbachol	DMX9K8F	Glaucoma/ocular hypertension	9C61	Approved	[453]
Methylscopolamine	DM5VWOB	Peptic ulcer	DA61	Approved	[457]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[458]

Drug(s) Affected By Lysosome-associated membrane glycoprotein 1 (LAMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[459]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[460]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[461]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[462]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[463]

Drug(s) Affected By Glucose-6-phosphate 1-dehydrogenase (G6PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[96]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[464]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[175]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[465]

Drug(s) Affected By Histidine--tRNA ligase, cytoplasmic (HARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[125]

Drug(s) Affected By ADP/ATP translocase 3 (SLC25A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[466]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[224]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[125]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[467]

Drug(s) Affected By Nucleoprotein TPR (TPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[246]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[468]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[143]

Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain E (HLA-E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[469]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[469]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[469]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[469]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[175]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[469]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]

Drug(s) Affected By Plastin-3 (PLS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[470]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[275]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[261]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[471]

Drug(s) Affected By Beta-enolase (ENO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[387]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[438]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[438]

Drug(s) Affected By Small nuclear ribonucleoprotein-associated proteins B and B' (SNRPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[411]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[472]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[473]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[242]

Drug(s) Affected By Glutamine synthetase (GLUL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[155]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[228]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[474]

Drug(s) Affected By Interferon gamma receptor 1 (IFNGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[475]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[476]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[477]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[196]

Drug(s) Affected By Ezrin (EZR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[355]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[478]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]

Drug(s) Affected By V-type proton ATPase subunit B, kidney isoform (ATP6V1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[354]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[196]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[254]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[174]

Drug(s) Affected By Histone H1.2 (H1-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[479]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[175]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[421]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[421]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[232]

Drug(s) Affected By 26S proteasome regulatory subunit 6A (PSMC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[480]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[244]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]

Drug(s) Affected By V-type proton ATPase subunit B, brain isoform (ATP6V1B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[481]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[482]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[226]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[410]

Drug(s) Affected By Trifunctional purine biosynthetic protein adenosine-3 (GART)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[483]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[355]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]

Drug(s) Affected By C-C motif chemokine 1 (CCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[484]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[232]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[485]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[486]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[275]
ACYLINE	DM9GRTK	Prostate cancer	2C82.0	Phase 2	[487]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[488]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[489]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[490]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[491]

Drug(s) Affected By Integrin alpha-6 (ITGA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[492]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[493]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[259]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[483]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[480]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[494]

Drug(s) Affected By Splicing factor, proline- and glutamine-rich (SFPQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[361]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[495]

Drug(s) Affected By Small ribosomal subunit protein uS3 (RPS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[285]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]

Drug(s) Affected By Tyrosine-protein kinase JAK1 (JAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[479]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[175]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[496]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[497]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[196]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]

Drug(s) Affected By High mobility group protein B2 (HMGB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[498]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[499]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[500]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]

Drug(s) Affected By Replication protein A 70 kDa DNA-binding subunit (RPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[501]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[502]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[503]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]

Drug(s) Affected By Calreticulin (CALR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[217]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[504]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[255]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[505]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[506]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[120]

Drug(s) Affected By Calnexin (CANX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[260]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[507]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[508]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[200]

Drug(s) Affected By Caspase-1 (CASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[475]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[509]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[510]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[511]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[512]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[259]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[513]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[514]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[515]

Drug(s) Affected By Elongation factor 1-delta (EEF1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[516]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[125]

Drug(s) Affected By Phosphatidylethanolamine-binding protein 1 (PEBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[517]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[518]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[519]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[224]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]

Drug(s) Affected By Protein disulfide-isomerase A3 (PDIA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[520]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[521]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[103]

Drug(s) Affected By Lipocalin-1 (LCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[522]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[472]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[523]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[174]
1-anilinonaphthalene-8-sulfonic acid	DMNGY0E	N. A.	N. A.	Investigative	[522]

Drug(s) Affected By S-adenosylmethionine synthase isoform type-2 (MAT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[524]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[525]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[524]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[526]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[527]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[368]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[528]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[529]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[530]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[531]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[166]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[532]

Drug(s) Affected By Stress-induced-phosphoprotein 1 (STIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[533]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[450]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[248]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[534]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[221]

Drug(s) Affected By Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[421]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[421]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[421]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]

Drug(s) Affected By Cleavage stimulation factor subunit 2 (CSTF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[284]

Drug(s) Affected By 5-hydroxytryptamine receptor 7 (HTR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Cyproheptadine	DM92AH3	Allergic rhinitis	CA08.0	Approved	[535]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[237]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[536]
PD-0325901	DM27D4J	Breast cancer	2C60-2C65	Phase 2	[537]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
SL65.0472	DMU5RKC	Cardiovascular disease	BA00-BE2Z	Discontinued in Phase 2	[89]
SB-269970	DM8WTGA	Sleep-wake disorder	7A00-7B2Z	Terminated	[535]
ICI-169369	DMQ0IOF	Anxiety disorder	6B00-6B0Z	Terminated	[535]

Drug(s) Affected By Histamine H1 receptor (HRH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[538]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[538]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[96]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[498]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[539]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[91]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[455]

Drug(s) Affected By Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[540]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[541]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[542]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[273]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[543]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[544]

Drug(s) Affected By Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[124]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[257]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[516]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[125]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[523]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[382]

Drug(s) Affected By Transgelin-2 (TAGLN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[361]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]

Drug(s) Affected By Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[195]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[198]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]

Drug(s) Affected By V-type proton ATPase catalytic subunit A (ATP6V1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[473]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]

Drug(s) Affected By Stress-70 protein, mitochondrial (HSPA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[545]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[506]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[466]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[546]

Drug(s) Affected By Flap endonuclease 1 (FEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[116]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[483]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[547]

Drug(s) Affected By Nicotinamide N-methyltransferase (NNMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[256]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[548]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[549]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[281]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[550]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[551]

Drug(s) Affected By Malate dehydrogenase, cytoplasmic (MDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[359]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[142]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[361]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[198]

Drug(s) Affected By Replication factor C subunit 5 (RFC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[501]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[433]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[547]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[281]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[534]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[552]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[234]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Bortezomib	DMNO38U	Leukemia		Approved	[222]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[161]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[266]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[553]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[232]

Drug(s) Affected By N-alpha-acetyltransferase 10 (NAA10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[221]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[125]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[246]

Drug(s) Affected By Lamina-associated polypeptide 2, isoform alpha (TMPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[132]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[246]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[554]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[555]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[556]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[557]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[365]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[558]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[559]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[560]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[561]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[562]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[563]

Drug(s) Affected By Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[239]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[564]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[257]

Drug(s) Affected By C-X-C motif chemokine 5 (CXCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[501]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[355]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[432]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[196]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[565]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[313]

Drug(s) Affected By Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[212]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[566]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[355]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[232]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[270]

Drug(s) Affected By ATP-binding cassette sub-family G member 1 (ABCG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[567]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[568]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[421]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[421]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[421]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[420]

Drug(s) Affected By Vesicle-fusing ATPase (NSF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[268]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[569]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]

Drug(s) Affected By Large ribosomal subunit protein uL18 (RPL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[266]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[246]

Drug(s) Affected By Microtubule-associated protein 1B (MAP1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[533]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[155]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[146]

Drug(s) Affected By 3-hydroxyanthranilate 3,4-dioxygenase (HAAO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[418]
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[570]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[267]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[571]

Drug(s) Affected By Nestin (NES)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[498]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[572]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[573]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[355]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[574]

Drug(s) Affected By Phosphatidylinositol transfer protein beta isoform (PITPNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[575]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[576]

Drug(s) Affected By Alanine--tRNA ligase, cytoplasmic (AARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[521]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[421]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[421]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[421]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[438]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[421]

Drug(s) Affected By Cysteine--tRNA ligase, cytoplasmic (CARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[420]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[577]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[421]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[421]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[420]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[257]

Drug(s) Affected By Serine--tRNA ligase, cytoplasmic (SARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[421]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[421]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[578]

Drug(s) Affected By Acyl-coenzyme A thioesterase 2, mitochondrial (ACOT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[175]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[579]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[265]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[580]

Drug(s) Affected By Transmembrane emp24 domain-containing protein 10 (TMED10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[581]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[582]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[380]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[583]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[581]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[584]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[585]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[586]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[587]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[588]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[589]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[590]

Drug(s) Affected By Matrix metalloproteinase-14 (MMP14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[591]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[592]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[432]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[593]
Cysteamine	DMSYFM8	Nephropathic cystinosis	5C60	Approved	[594]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[595]

Drug(s) Affected By 5-hydroxytryptamine receptor 6 (HTR6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[455]
Methamphetamine	DMPM4SK	Anxiety		Approved	[596]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
LYSERGIC ACID DIETHYLAMIDE	DMACMLO	Addictive disorder	6C50-6C5Z	Withdrawn from market	[597]
SB 258585	DM2QJKZ	Discovery agent	N.A.	Investigative	[598]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[232]

Drug(s) Affected By Glycine amidinotransferase, mitochondrial (GATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[195]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Ammonia	DMOEVK6	Coronary artery disease	BA80	Approved	[599]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 7 (PSMD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[411]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[480]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[255]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Bortezomib	DMNO38U	Leukemia		Approved	[222]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[250]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[382]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[564]

Drug(s) Affected By Rap1 GTPase-GDP dissociation stimulator 1 (RAP1GDS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[472]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[221]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[261]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[144]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]

Drug(s) Affected By Succinate--CoA ligase subunit alpha, mitochondrial (SUCLG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[600]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[418]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[265]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[265]

Drug(s) Affected By Ephrin type-B receptor 3 (EPHB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[282]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[196]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[601]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[602]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[602]

Drug(s) Affected By Trifunctional enzyme subunit beta, mitochondrial (HADHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[600]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[143]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[603]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[604]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[605]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[606]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[607]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[608]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[609]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[609]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[212]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[358]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[610]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[611]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[612]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[580]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[266]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[246]

Drug(s) Affected By Eukaryotic translation initiation factor 6 (EIF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[613]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[125]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[266]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[246]

Drug(s) Affected By Breast cancer anti-estrogen resistance protein 1 (BCAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[552]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[152]

Drug(s) Affected By Protein transport protein Sec61 subunit beta (SEC61B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[411]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[253]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[582]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]

Drug(s) Affected By Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[614]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[12]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[482]

Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[615]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]

Drug(s) Affected By Actin-related protein 3 (ACTR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[355]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]

Drug(s) Affected By ATP-binding cassette sub-family E member 1 (ABCE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[616]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[617]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[618]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[382]

Drug(s) Affected By 26S proteasome regulatory subunit 8 (PSMC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[270]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[619]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[481]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[620]

Drug(s) Affected By Small ribosomal subunit protein uS17 (RPS11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Bortezomib	DMNO38U	Leukemia		Approved	[222]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[621]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[266]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[622]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[381]

Drug(s) Affected By Rho-related GTP-binding protein RhoB (RHOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[124]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[623]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[201]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[624]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[625]

Drug(s) Affected By GTP-binding nuclear protein Ran (RAN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[626]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[627]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[628]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[629]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[630]

Drug(s) Affected By Large ribosomal subunit protein eL30 (RPL30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]

Drug(s) Affected By Large ribosomal subunit protein uL5 (RPL11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[266]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[174]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[631]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[226]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[632]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[410]

Drug(s) Affected By Transformer-2 protein homolog beta (TRA2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[355]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[260]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[269]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[633]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[523]

Drug(s) Affected By S-phase kinase-associated protein 1 (SKP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[606]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[463]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[263]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[634]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[261]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]

Drug(s) Affected By Small ribosomal subunit protein RACK1 (RACK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[635]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[353]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[636]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[636]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[637]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[463]

Drug(s) Affected By BOS complex subunit NOMO3 (NOMO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[246]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[239]

Drug(s) Affected By Microtubule-associated protein 1A (MAP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[638]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[470]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[418]

Drug(s) Affected By Dermcidin (DCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[639]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[604]

Drug(s) Affected By Enhancer of rudimentary homolog (ERH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[640]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[481]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[631]

Drug(s) Affected By Large ribosomal subunit protein eL19 (RPL19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[10]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[641]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[381]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[246]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[642]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[631]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[226]

Drug(s) Affected By Disabled homolog 2 (DAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[643]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[355]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[644]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[220]

Drug(s) Affected By Protein Dr1 (DR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[221]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[125]

Drug(s) Affected By Melanocyte-stimulating hormone receptor (MC1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[645]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[646]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[646]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[646]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[646]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[646]

Drug(s) Affected By Pro-neuregulin-1, membrane-bound isoform (NRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[501]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[212]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[236]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[355]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]

Drug(s) Affected By Guanine nucleotide-binding protein subunit alpha-12 (GNA12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[261]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[647]

Drug(s) Affected By Histone-lysine N-methyltransferase 2A (KMT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[648]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[649]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[650]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[651]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[254]

Drug(s) Affected By Neurogenic locus notch homolog protein 2 (NOTCH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[649]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[652]
Bortezomib	DMNO38U	Leukemia		Approved	[222]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[653]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[261]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[265]

Drug(s) Affected By Cleavage stimulation factor subunit 1 (CSTF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[246]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[244]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[564]

Drug(s) Affected By Focal adhesion kinase 1 (PTK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[654]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[655]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[433]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[656]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[657]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[658]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[659]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[660]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]

Drug(s) Affected By Elongation factor 1-alpha 2 (EEF1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[359]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[661]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[233]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[662]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]

Drug(s) Affected By Cytoskeleton-associated protein 4 (CKAP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[577]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[255]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[663]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[265]

Drug(s) Affected By KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[221]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[268]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[664]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[563]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[116]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[665]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[148]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[666]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[667]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[668]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[669]

Drug(s) Affected By Golgin subfamily A member 3 (GOLGA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[670]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]

Drug(s) Affected By Fibrinogen-like protein 1 (FGL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[329]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[418]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[671]

Drug(s) Affected By Histone-binding protein RBBP4 (RBBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[232]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[263]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]

Drug(s) Affected By Nuclear cap-binding protein subunit 1 (NCBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[232]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[550]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[380]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[672]

Drug(s) Affected By TBC1 domain family member 8B (TBC1D8B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[673]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[232]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[552]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]

Drug(s) Affected By Nuclear pore complex protein Nup160 (NUP160)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[479]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[269]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[263]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[653]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]

Drug(s) Affected By Transducin beta-like protein 3 (TBL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[618]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[266]

Drug(s) Affected By Aspartyl/asparaginyl beta-hydroxylase (ASPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]

Drug(s) Affected By SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[370]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[195]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[254]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]

Drug(s) Affected By Oviduct-specific glycoprotein (OVGP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[196]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[674]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[125]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[675]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]

Drug(s) Affected By Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[246]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[676]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[677]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[432]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[263]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]

Drug(s) Affected By Serine/arginine-rich splicing factor 5 (SRSF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[678]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[499]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[201]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[679]

Drug(s) Affected By Transcription intermediary factor 1-beta (TRIM28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[680]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[246]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[681]

Drug(s) Affected By Bcl-2-interacting killer (BIK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[682]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[683]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[684]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[513]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[514]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[273]

Drug(s) Affected By C-terminal-binding protein 1 (CTBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[152]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[685]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[387]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[152]

Drug(s) Affected By NAD(P) transhydrogenase, mitochondrial (NNT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[686]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[686]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[418]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[635]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[687]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[688]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[689]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[133]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[212]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]

Drug(s) Affected By Stromal interaction molecule 1 (STIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[690]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[418]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[691]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[246]
USNIC ACID	DMGOURX	Discovery agent	N.A.	Investigative	[692]

Drug(s) Affected By Sorting nexin-1 (SNX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[693]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[246]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[642]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[257]

Drug(s) Affected By Cullin-2 (CUL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[221]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[254]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[621]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]

Drug(s) Affected By Cullin-3 (CUL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[200]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[228]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[200]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[99]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[221]

Drug(s) Affected By Nuclear receptor coactivator 4 (NCOA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[201]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[694]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[695]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[695]

Drug(s) Affected By Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[172]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[167]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[420]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[175]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[696]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[361]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[232]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]

Drug(s) Affected By Protein DGCR6 (DGCR6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[105]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[265]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]

Drug(s) Affected By Single-minded homolog 2 (SIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[174]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[257]
geraniol	DMS3CBD	Discovery agent	N.A.	Investigative	[697]

Drug(s) Affected By Dihydropyrimidinase-related protein 3 (DPYSL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[479]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[421]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[421]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]

Drug(s) Affected By Src substrate cortactin (CTTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[698]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[175]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[421]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[421]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[421]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]

Drug(s) Affected By Flotillin-2 (FLOT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[479]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[260]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[99]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[124]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[256]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[699]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[418]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[700]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[270]

Drug(s) Affected By Protein RRP5 homolog (PDCD11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[200]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[701]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[701]

Drug(s) Affected By Golgin subfamily B member 1 (GOLGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[201]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[673]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[254]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[253]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[270]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 4 (CHD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[201]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[256]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[269]

Drug(s) Affected By Condensin complex subunit 2 (NCAPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[132]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[702]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[703]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[232]

Drug(s) Affected By Serum paraoxonase/lactonase 3 (PON3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[704]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[418]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[704]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[704]
Phenylacetic acid	DMQ95GE	Hepatic encephalopathy	DB99.5	Approved	[705]
RTR-003632	DM45NHF	N. A.	N. A.	Phase 2	[706]

Drug(s) Affected By Inorganic pyrophosphatase (PPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[198]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[221]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]

Drug(s) Affected By Periodic tryptophan protein 2 homolog (PWP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[259]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[707]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[707]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[708]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[246]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[246]

Drug(s) Affected By Poly(rC)-binding protein 1 (PCBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[709]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[260]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[710]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[710]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]

Drug(s) Affected By Delta(24)-sterol reductase (DHCR24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[711]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[167]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[175]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[712]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]

Drug(s) Affected By Scaffold attachment factor B1 (SAFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Bortezomib	DMNO38U	Leukemia		Approved	[222]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[152]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[270]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[266]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[246]

Drug(s) Affected By Microtubule-associated protein RP/EB family member 1 (MAPRE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[593]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[713]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[230]

Drug(s) Affected By Disks large homolog 2 (DLG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[714]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[550]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[275]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[253]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]

Drug(s) Affected By Adiponectin (ADIPOQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[715]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[715]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[716]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[717]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[715]
Cilazapril	DM4V6JA	Congestive heart failure	BD10	Approved	[718]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[719]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[715]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[720]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[721]

Drug(s) Affected By Serine/arginine-rich splicing factor 7 (SRSF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[201]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[221]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[372]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[722]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[629]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[723]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[724]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[725]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[726]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[696]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[206]

Drug(s) Affected By Histone H2A type 2-C (H2AC20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[359]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[472]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[500]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[196]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[133]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[521]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[155]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[727]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[143]

Drug(s) Affected By La-related protein 7 (LARP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[258]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[728]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[269]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[261]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[144]

Drug(s) Affected By Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[516]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[729]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[582]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[239]

Drug(s) Affected By Endoribonuclease LACTB2 (LACTB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[228]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[232]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]

Drug(s) Affected By Beta-actin-like protein 2 (ACTBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[217]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[196]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[466]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[730]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[381]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[731]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[732]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[267]

Drug(s) Affected By Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[733]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[196]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[418]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[380]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]

Drug(s) Affected By ATPase family AAA domain-containing protein 3B (ATAD3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[270]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[734]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[481]

Drug(s) Affected By Tau-tubulin kinase 1 (TTBK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[105]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[735]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[736]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[246]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[174]

Drug(s) Affected By CD276 antigen (CD276)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[475]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[735]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[198]

Drug(s) Affected By Microtubule-associated protein 1S (MAP1S)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]

Drug(s) Affected By Actin-binding LIM protein 2 (ABLIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[230]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[736]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[736]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[736]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[174]

Drug(s) Affected By Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[196]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[197]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[737]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]

Drug(s) Affected By Enhancer of mRNA-decapping protein 4 (EDC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[707]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[246]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[246]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[481]

Drug(s) Affected By Leiomodin-2 (LMOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[738]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]

Drug(s) Affected By Septin-14 (SEPTIN14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX46 (DDX46)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[438]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[438]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[266]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[246]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[246]

Drug(s) Affected By eIF5-mimic protein 2 (BZW1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[355]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[260]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[730]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[481]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[410]

Drug(s) Affected By ATP-dependent RNA helicase DHX30 (DHX30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[269]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[582]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[246]

Drug(s) Affected By Probable helicase senataxin (SETX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[421]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[421]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[421]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[266]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[246]

Drug(s) Affected By Nucleoporin p54 (NUP54)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]

Drug(s) Affected By Low-density lipoprotein receptor-related protein 10 (LRP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[232]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[91]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]

Drug(s) Affected By Centromere protein V (CENPV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[232]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[437]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[261]

Drug(s) Affected By RNA-binding Raly-like protein (RALYL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[254]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]

Drug(s) Affected By THO complex subunit 4 (ALYREF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[246]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[739]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[691]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[246]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[246]

Drug(s) Affected By GRIP and coiled-coil domain-containing protein 2 (GCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[355]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[673]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[232]

Drug(s) Affected By Cell division cycle and apoptosis regulator protein 1 (CCAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[468]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[740]
Bortezomib	DMNO38U	Leukemia		Approved	[741]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[742]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[269]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[741]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-2 (SIRT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[368]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[743]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[744]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[745]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[746]
Nicotinamide	DMUPE07	Acne vulgaris	ED80	Approved	[747]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[516]

Drug(s) Affected By Diacylglycerol lipase-beta (DAGLB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[498]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[268]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[418]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[261]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]

Drug(s) Affected By Paraneoplastic antigen Ma1 (PNMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[418]

Drug(s) Affected By Diphosphoinositol polyphosphate phosphohydrolase 3-alpha (NUDT10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DIADENOSINE TETRAPHOSPHATE	DMTJOEL	Cardiac arrhythmias	BC9Z	Phase 2	[748]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[267]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[245]

Drug(s) Affected By Nuclear protein localization protein 4 homolog (NPLOC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[620]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[749]

Drug(s) Affected By TBC1 domain family member 15 (TBC1D15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[673]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[418]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[230]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]

Drug(s) Affected By PEST proteolytic signal-containing nuclear protein (PCNP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[260]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[269]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[246]

Drug(s) Affected By Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (DHX38)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[246]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[750]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[266]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]

Drug(s) Affected By Nectin-2 (NECTIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[730]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[265]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]

Drug(s) Affected By Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (ATP2A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[273]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[91]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[751]

Drug(s) Affected By Major histocompatibility complex class I-related gene protein (MR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[469]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[469]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[469]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[236]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[469]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[469]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[469]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[355]

Drug(s) Affected By Liver-expressed antimicrobial peptide 2 (LEAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[143]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[278]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[552]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[127]

Drug(s) Affected By DNA topoisomerase I, mitochondrial (TOP1MT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[261]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[583]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[752]

Drug(s) Affected By PAT complex subunit CCDC47 (CCDC47)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[753]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[642]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[244]

Drug(s) Affected By Far upstream element-binding protein 1 (FUBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[483]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[521]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[313]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]

Drug(s) Affected By SH3 domain-containing kinase-binding protein 1 (SH3KBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[246]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[155]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[228]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[195]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[418]

Drug(s) Affected By ADP-ribosylation factor-like protein 8A (ARL8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Bortezomib	DMNO38U	Leukemia		Approved	[222]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[230]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[127]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 14B (PPP1R14B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[284]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[284]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[754]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[755]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]

Drug(s) Affected By BTB/POZ domain-containing protein KCTD12 (KCTD12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[175]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[415]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[228]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[738]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]

Drug(s) Affected By Small ribosomal subunit protein mS39 (PTCD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[224]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[756]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[244]

Drug(s) Affected By PDZ and LIM domain protein 5 (PDLIM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[479]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[99]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]

Drug(s) Affected By Serine/threonine-protein phosphatase PGAM5, mitochondrial (PGAM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[254]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[701]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[701]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]

Drug(s) Affected By Glutamate decarboxylase 1 (GAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[757]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[758]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[684]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]

Drug(s) Affected By Proteasome subunit beta type-7 (PSMB7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[759]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[760]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[380]

Drug(s) Affected By 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[242]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[761]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[224]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[576]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[754]
Tanespimycin	DMNLQHK	Breast cancer	2C60-2C65	Phase 2	[762]

Drug(s) Affected By Nucleosome assembly protein 1-like 4 (NAP1L4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[246]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[701]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[663]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[261]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[707]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[481]

Drug(s) Affected By Transmembrane 9 superfamily member 2 (TM9SF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[230]

Drug(s) Affected By Copine-1 (CPNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[133]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[133]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[438]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[438]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[125]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[479]

Drug(s) Affected By T-complex protein 1 subunit eta (CCT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[663]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[576]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[266]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[246]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[239]

Drug(s) Affected By Protein arginine N-methyltransferase 1 (PRMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[763]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[764]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[616]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[765]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]

Drug(s) Affected By Endophilin-A2 (SH3GL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[418]
BAICALEIN	DM4C7E6	Influenza virus infection	1E30-1E32	Phase 2	[766]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[246]
biochanin A	DM0HPWY	Discovery agent	N.A.	Investigative	[767]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[382]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[768]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[259]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[769]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[770]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[478]

Drug(s) Affected By Condensin complex subunit 3 (NCAPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[547]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]

Drug(s) Affected By Myb-binding protein 1A (MYBBP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[701]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[750]

Drug(s) Affected By Coronin-1B (CORO1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[771]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[691]

Drug(s) Affected By Histone H2A.J (H2AJ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[198]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[283]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]

Drug(s) Affected By MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[246]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[499]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[772]

Drug(s) Affected By Fibroblast growth factor-binding protein 2 (FGFBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[691]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[773]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[774]

Drug(s) Affected By Apoptosis facilitator Bcl-2-like protein 14 (BCL2L14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[714]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[514]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[273]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[775]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[269]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[776]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[687]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[777]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[212]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[778]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[779]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[780]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[459]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[614]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[781]

Drug(s) Affected By RNA cytidine acetyltransferase (NAT10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Idelalisib	DM602WT	Chronic lymphocytic leukaemia	2A82.0	Approved	[782]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[782]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]

Drug(s) Affected By Growth hormone-inducible transmembrane protein (GHITM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[175]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[260]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[239]

Drug(s) Affected By Damage-control phosphatase ARMT1 (ARMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]

Drug(s) Affected By Exosome complex component RRP41 (EXOSC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[201]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[255]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[710]

Drug(s) Affected By Synembryn-A (RIC8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[246]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[246]

Drug(s) Affected By Kinesin-like protein KIF13B (KIF13B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[644]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[783]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[261]

Drug(s) Affected By Serine incorporator 1 (SERINC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[201]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[232]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]

Drug(s) Affected By Phenylalanine--tRNA ligase beta subunit (FARSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[221]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[268]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]

Drug(s) Affected By ATPase family AAA domain-containing protein 3A (ATAD3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[221]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[784]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[734]

Drug(s) Affected By Endoplasmic reticulum aminopeptidase 1 (ERAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[700]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[269]

Drug(s) Affected By Methionine adenosyltransferase 2 subunit beta (MAT2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[221]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[785]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[786]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[642]

Drug(s) Affected By Very-long-chain (HACD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
EMODIN	DMAEDQG	Coronavirus Disease 2019 (COVID-19)	1D6Y	Terminated	[787]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[239]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[620]

Drug(s) Affected By Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[281]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[701]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[788]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[734]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[789]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]

Drug(s) Affected By Ribosome-binding protein 1 (RRBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[483]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[415]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[468]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[790]

Drug(s) Affected By Ataxin-10 (ATXN10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[642]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[791]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[272]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[500]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[232]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[273]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]

Drug(s) Affected By DnaJ homolog subfamily B member 11 (DNAJB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[142]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[772]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[792]

Drug(s) Affected By Testin (TES)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[201]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[793]

Drug(s) Affected By Translocation protein SEC63 homolog (SEC63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Indomethacin	DMSC4A7	Bursitis		Approved	[794]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[125]

Drug(s) Affected By Cysteine and histidine-rich domain-containing protein 1 (CHORDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]

Drug(s) Affected By NADH-cytochrome b5 reductase 1 (CYB5R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[200]
Bortezomib	DMNO38U	Leukemia		Approved	[222]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[96]

Drug(s) Affected By Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[772]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[263]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[225]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[250]

Drug(s) Affected By Nuclear pore complex protein Nup50 (NUP50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[263]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]

Drug(s) Affected By Serine/threonine-protein kinase TAO2 (TAOK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[606]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[795]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[732]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]

Drug(s) Affected By Sorting nexin-6 (SNX6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[796]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[265]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[125]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[382]

Drug(s) Affected By Translocon-associated protein subunit gamma (SSR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[479]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[797]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[99]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]

Drug(s) Affected By DNA-binding protein SATB2 (SATB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[415]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[737]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[798]

Drug(s) Affected By Serine/arginine repetitive matrix protein 2 (SRRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[246]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[468]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[710]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]

Drug(s) Affected By Phenylalanine--tRNA ligase alpha subunit (FARSA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Bortezomib	DMNO38U	Leukemia		Approved	[222]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[244]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]

Drug(s) Affected By Fanconi-associated nuclease 1 (FAN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[799]

Drug(s) Affected By Kelch domain-containing protein 2 (KLHDC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[418]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[732]

Drug(s) Affected By Thyroid hormone receptor-associated protein 3 (THRAP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[268]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[269]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[253]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[266]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[246]

Drug(s) Affected By Serine-threonine kinase receptor-associated protein (STRAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[635]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[800]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[792]

Drug(s) Affected By RNA-splicing ligase RtcB homolog (RTCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[239]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[801]

Drug(s) Affected By Nucleolar complex protein 2 homolog (NOC2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[638]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[701]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]

Drug(s) Affected By TRPM8 channel-associated factor 1 (TCAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[232]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]

Drug(s) Affected By Talin-2 (TLN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[802]
Haloperidol	DM96SE0	Delirium		Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]

Drug(s) Affected By Beta-secretase 2 (BACE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[803]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[105]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[265]

Drug(s) Affected By FH1/FH2 domain-containing protein 1 (FHOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[238]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[269]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[266]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]

Drug(s) Affected By Chloride intracellular channel protein 4 (CLIC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[203]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]

Drug(s) Affected By Cytoplasmic dynein 1 light intermediate chain 1 (DYNC1LI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[269]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[246]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[246]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[382]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[533]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[207]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[606]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[288]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[804]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[805]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[806]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[807]

Drug(s) Affected By Flavin-containing monooxygenase 3 (FMO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[418]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[808]
Almogran	DM7I64Z	Migraine	8A80	Approved	[809]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[810]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[811]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[812]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[813]

Drug(s) Affected By Sodium-dependent dopamine transporter (SLC6A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[814]
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[815]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[816]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[452]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Dextroamphetamine	DMMIHVP	Attention deficit hyperactivity disorder	6A05.Z	Approved	[817]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[269]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[818]

Drug(s) Affected By Disrupted in schizophrenia 1 protein (DISC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[257]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[144]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[275]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[275]
Dextroamphetamine	DMMIHVP	Attention deficit hyperactivity disorder	6A05.Z	Approved	[819]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]

Drug(s) Affected By Oxytocin-neurophysin 1 (OXT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[820]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[820]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[821]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[822]
Fructose	DM43AN2	Vomiting	MD90	Approved	[96]
Ketoprofen	DMRKXPT	Bursitis		Approved	[96]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[823]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[824]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[825]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[826]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[827]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]

Drug(s) Affected By Leptin (LEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[715]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[828]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[829]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[830]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[715]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[715]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[720]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[831]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[832]

Drug(s) Affected By Sodium-dependent serotonin transporter (SLC6A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[833]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[106]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[834]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[835]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[836]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[837]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[835]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]

Drug(s) Affected By 5-hydroxytryptamine receptor 2C (HTR2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[838]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[838]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[838]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[839]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[228]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]

Drug(s) Affected By Dysbindin (DTNBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[195]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[185]
Haloperidol	DM96SE0	Delirium		Approved	[840]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[409]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[246]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[246]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[144]

Drug(s) Affected By Glutathione S-transferase A1 (GSTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[841]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[842]
Thiotepa	DMIZKOP	Breast cancer	2C60-2C65	Approved	[843]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[844]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[845]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[846]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[847]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[848]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]

Drug(s) Affected By 5-hydroxytryptamine receptor 3A (HTR3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[438]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[849]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[282]
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[850]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[851]
Hydromorphone	DMHP21E	Back pain	ME84.Z	Approved	[852]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[143]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[849]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[438]

Drug(s) Affected By Ribosyldihydronicotinamide dehydrogenase (NQO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[175]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[853]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[800]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[854]

Drug(s) Affected By Cytochrome P450 2J2 (CYP2J2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[855]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[856]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[857]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[858]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[855]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[855]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[859]

Drug(s) Affected By D(1A) dopamine receptor (DRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[96]
Haloperidol	DM96SE0	Delirium		Approved	[89]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[860]
Pergolide mesylate	DM5GKOV	N. A.	N. A.	Approved	[861]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[89]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[862]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[863]
Methamphetamine	DMPM4SK	Anxiety		Approved	[864]
Bardoxolone methyl	DMODA2X	Mixed connective tissue disease	4A43.3	Phase 3	[865]

Drug(s) Affected By Circadian locomoter output cycles protein kaput (CLOCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[866]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[867]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[868]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[869]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[243]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[246]
CGS 21680	DMZ0TGY	Discovery agent	N.A.	Investigative	[870]

Drug(s) Affected By Catechol O-methyltransferase (COMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[871]
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[871]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[871]
Modafinil	DMYILBE	Malignant glioma	2A00.0	Approved	[872]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[871]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[873]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]

Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[213]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[874]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[265]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[875]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[124]
Methyldopa	DM5I621	Hypertension	BA00-BA04	Approved	[876]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]

Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[877]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[878]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[879]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[879]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[880]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[881]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[882]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[883]

Drug(s) Affected By Flavin-containing monooxygenase 1 (FMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[345]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[884]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[779]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Dihydroxyacetone	DMM1LG2	Sunburn	EJ40	Approved	[885]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[779]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[105]

Drug(s) Affected By Methylenetetrahydrofolate reductase (MTHFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[886]
Benazepril	DMH1M9B	Hypertension	BA00-BA04	Approved	[887]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[888]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[889]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]

Drug(s) Affected By Synaptosomal-associated protein 25 (SNAP25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[753]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[890]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[184]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[196]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]

Drug(s) Affected By 5-hydroxytryptamine receptor 2A (HTR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[96]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[115]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[891]
Haloperidol	DM96SE0	Delirium		Approved	[891]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[455]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[892]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[223]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[893]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D4 receptor (D4R)	TTE0A2F	DRD4_HUMAN	Modulator	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[4]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[5]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[6]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[7]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[5]
Cytochrome P450 2A6 (CYP2A6)	DEJVYAZ	CP2A6_HUMAN	Substrate	[8]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[9]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[7]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein theta	OTWG7F3H	1433T_HUMAN	Gene/Protein Processing	[10]
2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP)	OTB8HCED	CN37_HUMAN	Gene/Protein Processing	[10]
26S proteasome non-ATPase regulatory subunit 14 (PSMD14)	OTJWHMZ5	PSDE_HUMAN	Gene/Protein Processing	[10]
26S proteasome non-ATPase regulatory subunit 7 (PSMD7)	OT7PZZ4K	PSMD7_HUMAN	Gene/Protein Processing	[10]
26S proteasome regulatory subunit 6A (PSMC3)	OTSKT0JI	PRS6A_HUMAN	Gene/Protein Processing	[10]
26S proteasome regulatory subunit 8 (PSMC5)	OTJOORMR	PRS8_HUMAN	Gene/Protein Processing	[10]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[11]
3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)	OT7RJON4	HCD2_HUMAN	Gene/Protein Processing	[10]
3-hydroxyanthranilate 3,4-dioxygenase (HAAO)	OTK9Y6SG	3HAO_HUMAN	Gene/Protein Processing	[12]
5-hydroxytryptamine receptor 2A (HTR2A)	OTWXJX0M	5HT2A_HUMAN	Drug Response	[13]

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