Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMP6SC2)

Drug Name
Irinotecan Drug Info
Synonyms
Biotecan; Camptosar; Irinotecanum; IRINOTECAN HYDROCHLORIDE Trihydrate; Irinotecan Hcl; Irinotecan hydrochloride; CP0; Biotecan (TN); Campto (TN); Camptosar (TN); Irinotecan (INN); Irinotecan [INN:BAN]; Irinotecanum [INN-Latin]; IRINOTECAN, CPT-11; Camptosar, Campto, CPT-11, Irinotecan; (+)-Irinotecan; (4S)-4,11-DIETHYL-4-HYDROXY-3,14-DIOXO-3,4,12,14-TETRAHYDRO-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL 1,4'-BIPIPERIDINE-1'-CARBOXYLATE; (4S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-4,12-dihydro-1H-pyrano[3,4-f]quinolino[2,3-a]indolizin-9-yl 4-piperidylpiperidinecarboxylate; Irinotecan (TOPO1 inhibitor); Onivyde
Indication
Disease Entry ICD 11 Status REF
Adenocarcinoma 2D40 Approved [1]
Advanced cancer 2A00-2F9Z Approved [1]
Appendiceal neoplasm Approved [1]
Astrocytoma 2A00.0Y Approved [1]
Brain glioma Approved [1]
Colon adenocarcinoma Approved [1]
Colorectal cancer 2B91.Z Approved [2]
Endocrine gland neoplasm Approved [1]
Kidney neoplasm Approved [1]
Metastasis from malignant tumor of colon Approved [1]
Peritoneal neoplasm Approved [1]
Rectal adenocarcinoma 2B92 Approved [1]
Rectal neoplasm Approved [1]
Rectum mucinous adenocarcinoma Approved [1]
Adult glioblastoma Investigative [1]
Colon cancer 2B90.Z Investigative [1]
Colon mucinous adenocarcinoma Investigative [1]
Diarrhea ME05.1 Investigative [1]
Gastric cancer 2B72 Investigative [1]
Neuroblastoma 2D11.2 Investigative [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
60838
ChEBI ID
CHEBI:80630
CAS Number
CAS 97682-44-5
TTD Drug ID
DMP6SC2
VARIDT Drug ID
DR00112
INTEDE Drug ID
DR0881

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Patented Agent(s)
Discontinued Drug(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting DNA topoisomerase I (TOP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Topotecan DMP6G8T Central nervous system neoplasm Approved [3]
B-Lactams DMR8YD6 Bacterial infection 1A00-1C4Z Approved [20]
Belotecan hydrocholoride DM3SRJZ Small-cell lung cancer 2C25.Y Approved [21]
Topetecan DMAE6LK Small-cell lung cancer 2C25.Y Approved [22]
Karenitecin DMCRGY4 Lung cancer 2C25.0 Phase 3 [23]
Camptothecin DM6CHNJ Solid tumour/cancer 2A00-2F9Z Phase 3 [24]
Exatecan DMCA7FN Solid tumour/cancer 2A00-2F9Z Phase 3 [25]
Edotecarin DM3ZL7D Gastric adenocarcinoma 2B72 Phase 3 [26]
Rubitecan DMDWU1S Human immunodeficiency virus infection 1C62 Phase 3 [27]
Etirinotecan pegol DMQHX1Y Breast cancer 2C60-2C65 Phase 3 [28]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Multidrug resistance-associated protein 1 (ABCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [29]
Methotrexate DM2TEOL Anterior urethra cancer Approved [30]
Folic Acid DMEMBJC Colorectal carcinoma Approved [31]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [33]
Verapamil DMA7PEW Angina pectoris BA40 Approved [34]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [35]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [36]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [37]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [155]
Folic Acid DMEMBJC Colorectal carcinoma Approved [31]
Methotrexate DM2TEOL Anterior urethra cancer Approved [156]
Quercetin DM3NC4M Obesity 5B81 Approved [157]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [158]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [159]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [160]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [161]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [161]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [162]
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Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [38]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
Folic Acid DMEMBJC Colorectal carcinoma Approved [40]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [41]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [42]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [43]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [44]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [45]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [46]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [47]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [34]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [48]
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
Folic Acid DMEMBJC Colorectal carcinoma Approved [50]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [49]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [49]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [51]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [49]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [52]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [54]
Methotrexate DM2TEOL Anterior urethra cancer Approved [55]
Folic Acid DMEMBJC Colorectal carcinoma Approved [56]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [57]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [58]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [59]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [60]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [59]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [61]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [62]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Multidrug resistance-associated protein 4 (ABCC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Folic Acid DMEMBJC Colorectal carcinoma Approved [64]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [65]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [66]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [34]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [67]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [68]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [69]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [34]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [70]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Multidrug resistance-associated protein 5 (ABCC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [71]
Folic Acid DMEMBJC Colorectal carcinoma Approved [71]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [65]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [72]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [73]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [74]
FLUORESCEIN DMQTFAO Ocular disease 1F00.1Z Approved [75]
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [76]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [77]
[3H]cAMP DMZRQU7 Discovery agent N.A. Investigative [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [79]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [80]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [81]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [82]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [83]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [84]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [85]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [86]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [80]
Verapamil DMA7PEW Angina pectoris BA40 Approved [87]
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [139]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [140]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [141]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [142]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [143]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [143]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [144]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [145]
Capsaicin DMGMF6V Back pain ME84.Z Approved [146]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [147]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [88]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [89]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [90]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [12]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [91]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [92]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [93]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [94]
Verapamil DMA7PEW Angina pectoris BA40 Approved [95]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [12]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [96]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [12]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [12]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [12]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [97]
Verapamil DMA7PEW Angina pectoris BA40 Approved [98]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [12]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [12]
Metronidazole DMTIVEN Abscess Approved [99]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [100]
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Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [101]
Verapamil DMA7PEW Angina pectoris BA40 Approved [97]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [102]
Estrone DM5T6US Acne vulgaris ED80 Approved [103]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [104]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [105]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [106]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [107]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Carboxylesterase 1 (CES1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Enalapril DMNFUZR Congestive heart failure BD10 Approved [109]
Candesartan DMRK8OT Chronic heart failure BD1Z Approved [110]
Salbutamol DMN9CWF Acute asthma CA23 Approved [111]
Methylphenidate DM7SJD6 Attention deficit hyperactivity disorder 6A05.Z Approved [112]
PSI-7977 DMLSUWZ HCV 1-6 infection 1E51 Approved [113]
Rufinamide DMWE60C Epilepsy 8A60-8A68 Approved [114]
Dexmethylphenidate DMUQE2A Attention deficit hyperactivity disorder 6A05.Z Approved [115]
MK-4827 DMLYGH4 Ovarian cancer 2C73 Phase 3 [116]
Dabigatran etexilate DMRDZ4X Venous thromboembolism BD72 Phase 3 [117]
Pradaxa DM2ZYX9 Stroke 8B20 Phase 3 [118]
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Drug(s) Metabolized By Carboxylesterase 3 (CES3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pyrethroids DM1794O Pest attack N.A. Phase 2 [119]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
PARAOXON DMN4ZKC Discovery agent N.A. Investigative [136]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [137]
S 3025 DMZN0RW Discovery agent N.A. Investigative [136]
Nitrophenyl acetate DMHSD8A N. A. N. A. Investigative [138]
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Drug(s) Metabolized By Carboxylesterase 2 (CES2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [120]
Rufinamide DMWE60C Epilepsy 8A60-8A68 Approved [114]
Dabigatran etexilate DMRDZ4X Venous thromboembolism BD72 Phase 3 [117]
Pradaxa DM2ZYX9 Stroke 8B20 Phase 3 [118]
Drug(s) Metabolized By Beta-glucuronidase (uidA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Conjugated Estrogens DMLT0E1 Dyspareunia GA12 Approved [121]
SN-38G DM2UVNB N. A. N. A. Investigative [122]
Indomethacin glucuronide DMSBENK N. A. N. A. Investigative [123]
Ketoprofen glucuronide DMX2FL3 N. A. N. A. Investigative [124]
Drug(s) Affected By Cocaine esterase (CES2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [125]
Dextropropoxyphene DM23HCX Pain MG30-MG3Z Approved [126]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [129]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [130]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Testosterone enanthate DMB6871 N. A. N. A. Approved [132]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [133]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Liver carboxylesterase 1 (CES1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [148]
Dextropropoxyphene DM23HCX Pain MG30-MG3Z Approved [126]
Selenium DM25CGV N. A. N. A. Approved [149]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [150]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [152]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [125]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [153]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [154]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [133]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lopinavir DMITQS0 Human immunodeficiency virus infection 1C62 Approved [163]
Sulfinpyrazone DMEV954 Gout FA25 Approved [164]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [165]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [166]
Methotrexate DM2TEOL Anterior urethra cancer Approved [156]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [167]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [168]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [159]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [169]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
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Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [171]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [171]
Gefitinib DM15F0X Colon adenocarcinoma Approved [172]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [173]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [174]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [175]
Methotrexate DM2TEOL Anterior urethra cancer Approved [176]
Quercetin DM3NC4M Obesity 5B81 Approved [177]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [178]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [179]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [180]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [181]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [182]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [183]
Cepharanthine DM9Y5JB N. A. N. A. Approved [184]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [185]
Clozapine DMFC71L Schizophrenia 6A20 Approved [186]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [187]
Trifluoperazine DMKBYWI Anxiety Approved [188]
Olanzapine DMPFN6Y Bipolar depression Approved [186]
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Drug(s) Affected By Solute carrier organic anion transporter family member 1B1 (SLCO1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Enalapril DMNFUZR Congestive heart failure BD10 Approved [189]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [190]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [191]
Repaglinide DM5SXUV Diabetic complication 5A2Y Approved [192]
Methotrexate DM2TEOL Anterior urethra cancer Approved [193]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [194]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [195]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [195]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [196]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [197]
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Drug(s) Affected By Thiopurine S-methyltransferase (TPMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [173]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [198]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [199]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [200]
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [201]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [202]
Bendroflumethiazide DM7EVLC High blood pressure BA00 Approved [203]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
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Drug(s) Affected By Cytochrome P450 2A6 (CYP2A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tegafur DM31ZQM Solid tumour/cancer 2A00-2F9Z Approved [205]
Methoxsalen DME8FZ9 Cutaneous T-cell lymphoma 2B01 Approved [206]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [207]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [208]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [209]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [82]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [210]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [211]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [212]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [213]
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Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [140]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [214]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [143]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [142]
Capsaicin DMGMF6V Back pain ME84.Z Approved [215]
Zafirlukast DMHNQOG Asthma CA23 Approved [216]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [143]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [217]
Fluconazole DMOWZ6B Cryptococcal meningitis Approved [142]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [143]
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Drug(s) Affected By Annexin A2 (ANXA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [218]
Quercetin DM3NC4M Obesity 5B81 Approved [219]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [220]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [222]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [223]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [225]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [226]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
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Drug(s) Affected By Diamine acetyltransferase 1 (SAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Selenium DM25CGV N. A. N. A. Approved [149]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [228]
Methotrexate DM2TEOL Anterior urethra cancer Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [231]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [231]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By FXYD domain-containing ion transport regulator 3 (FXYD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [233]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [234]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [237]
Raltitrexed DMT9K8G Rectal adenocarcinoma 2B92 Approved [238]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [239]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [238]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By B-cell CLL/lymphoma 9 protein (BCL9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [148]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [243]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
Calphostin C DM9X2D0 N. A. N. A. Terminated [245]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 1 (CHD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Indomethacin DMSC4A7 Bursitis Approved [250]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [251]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [149]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prostaglandin E synthase (PTGES)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [252]
Selenium DM25CGV N. A. N. A. Approved [149]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [253]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [254]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [255]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Menthol DMG2KW7 Back pain ME84.Z Approved [256]
Mestranol DMG3F94 Contraception QA21 Approved [252]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [257]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By tRNA (TRDMT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [260]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [262]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [263]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [235]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Guanine nucleotide exchange factor DBS (MCF2L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [263]
Selenium DM25CGV N. A. N. A. Approved [149]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [264]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [227]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [134]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fanconi anemia group G protein (FANCG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [267]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [270]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Monocarboxylate transporter 5 (SLC16A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [271]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [178]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [272]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [274]
Gefitinib DM15F0X Colon adenocarcinoma Approved [275]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [276]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [277]
Etretinate DM2CZFA Keratosis ED56 Approved [278]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [279]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [280]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [281]
Quercetin DM3NC4M Obesity 5B81 Approved [282]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [283]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prominin-1 (PROM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [175]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [284]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [285]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [286]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [287]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [288]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By A-kinase anchor protein 10, mitochondrial (AKAP10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [290]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [267]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [274]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [291]
Methotrexate DM2TEOL Anterior urethra cancer Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hyaluronan mediated motility receptor (HMMR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [293]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [279]
Methotrexate DM2TEOL Anterior urethra cancer Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [279]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G2/mitotic-specific cyclin-B2 (CCNB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [267]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [274]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Methotrexate DM2TEOL Anterior urethra cancer Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [294]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [295]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [296]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock 70 kDa protein 4L (HSPA4L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [297]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [298]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Ethanol DMDRQZU Chronic pain MG30 Approved [300]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldehyde dehydrogenase 1A1 (ALDH1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [175]
Methotrexate DM2TEOL Anterior urethra cancer Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [301]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [302]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [303]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [304]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [305]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [148]
Verapamil DMA7PEW Angina pectoris BA40 Approved [307]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [308]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [307]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [309]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [310]
Methotrexate DM2TEOL Anterior urethra cancer Approved [311]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [312]
Quercetin DM3NC4M Obesity 5B81 Approved [313]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [314]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [315]
Gefitinib DM15F0X Colon adenocarcinoma Approved [316]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [317]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [318]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [317]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [319]
Selenium DM25CGV N. A. N. A. Approved [320]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [321]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [322]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lactotransferrin (LTF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [323]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [324]
Capsaicin DMGMF6V Back pain ME84.Z Approved [325]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [326]
Budesonide DMJIBAW Allergic rhinitis CA08.0 Approved [327]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [328]
Arsenic DMTL2Y1 N. A. N. A. Approved [329]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [323]
Diphenylpyraline DMW4X37 Allergic rhinitis CA08.0 Approved [330]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [331]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histidine-rich glycoprotein (HRG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [332]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [333]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [225]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [334]
Olanzapine DMPFN6Y Bipolar depression Approved [335]
Arsenic DMTL2Y1 N. A. N. A. Approved [336]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [209]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [131]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thy-1 membrane glycoprotein (THY1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [314]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [324]
Ethanol DMDRQZU Chronic pain MG30 Approved [300]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Paclitaxel DMLB81S Breast carcinoma Approved [338]
Bortezomib DMNO38U Leukemia Approved [339]
Arsenic DMTL2Y1 N. A. N. A. Approved [340]
Ximelegatran DMU8ANS Myocardial infarction BA41-BA43 Approved [341]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [342]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor I (IGF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dantrolene DM1D8XY Hyperthermia MG26 Approved [343]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [344]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [345]
Quercetin DM3NC4M Obesity 5B81 Approved [346]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [347]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [347]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [348]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Testosterone DM7HUNW Hot flushes GA30 Approved [349]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myeloperoxidase (MPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dapsone DM4LT8A Acne vulgaris ED80 Approved [173]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [173]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [173]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [351]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [352]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [253]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [353]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [354]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [355]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [356]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [357]
Fructose DM43AN2 Vomiting MD90 Approved [173]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [358]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [359]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [308]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [360]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [361]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [362]
Methotrexate DM2TEOL Anterior urethra cancer Approved [363]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [267]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [364]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [274]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Selenium DM25CGV N. A. N. A. Approved [365]
Etretinate DM2CZFA Keratosis ED56 Approved [278]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [366]
Methotrexate DM2TEOL Anterior urethra cancer Approved [367]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [368]
Quercetin DM3NC4M Obesity 5B81 Approved [369]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin alpha-V (ITGAV)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [310]
Epinephrine DM3KJBC Acute asthma CA23 Approved [370]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [372]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Testosterone enanthate DMB6871 N. A. N. A. Approved [132]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Annexin A6 (ANXA6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Benzatropine DMF7EXL Parkinsonian disorder Approved [373]
Clozapine DMFC71L Schizophrenia 6A20 Approved [373]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [374]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [209]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibroblast growth factor 2 (FGF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [375]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [148]
Diazepam DM08E9O Alcohol withdrawal Approved [376]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [377]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [378]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [379]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [380]
Isradipine DMA5XGH Hypertension BA00-BA04 Approved [381]
Valdecoxib DMAY7H4 Osteoarthritis FA00-FA05 Approved [382]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sulfotransferase 1A3 (SULT1A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [209]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [383]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ethanol DMDRQZU Chronic pain MG30 Approved [384]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [385]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [386]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [387]
Epinephrine DM3KJBC Acute asthma CA23 Approved [388]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [388]
Estrone DM5T6US Acne vulgaris ED80 Approved [389]
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Drug(s) Affected By Serine/threonine-protein kinase A-Raf (ARAF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [390]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [391]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [392]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [270]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [393]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [394]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [270]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [395]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [396]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [360]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [397]
Methotrexate DM2TEOL Anterior urethra cancer Approved [229]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [398]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [399]
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Drug(s) Affected By Collagen alpha-1(VI) chain (COL6A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [347]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [347]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Testosterone enanthate DMB6871 N. A. N. A. Approved [132]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [400]
Paclitaxel DMLB81S Breast carcinoma Approved [338]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [347]
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Drug(s) Affected By Keratin, type II cytoskeletal 5 (KRT5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [401]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [347]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [347]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [402]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [324]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [403]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [347]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [404]
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Drug(s) Affected By Nidogen-1 (NID1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [405]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [153]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [287]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [400]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [374]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Arsenic DMTL2Y1 N. A. N. A. Approved [336]
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Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [406]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [323]
Gefitinib DM15F0X Colon adenocarcinoma Approved [407]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [344]
Selenium DM25CGV N. A. N. A. Approved [408]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [409]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [410]
Methotrexate DM2TEOL Anterior urethra cancer Approved [411]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [412]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [413]
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Drug(s) Affected By Protein C-ets-2 (ETS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [414]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Folic Acid DMEMBJC Colorectal carcinoma Approved [416]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [417]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [418]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [419]
Selenium DM25CGV N. A. N. A. Approved [149]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [420]
Etretinate DM2CZFA Keratosis ED56 Approved [421]
Methotrexate DM2TEOL Anterior urethra cancer Approved [422]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [284]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [423]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [398]
Quercetin DM3NC4M Obesity 5B81 Approved [424]
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Drug(s) Affected By Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PPP3CB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [425]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [426]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [427]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [393]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By SH2/SH3 adapter protein NCK1 (NCK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [428]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [221]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [429]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [430]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [431]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [230]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Early growth response protein 1 (EGR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [432]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [433]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Quercetin DM3NC4M Obesity 5B81 Approved [434]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [435]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [436]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [437]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [438]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [439]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [432]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [433]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [279]
Methotrexate DM2TEOL Anterior urethra cancer Approved [440]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [368]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [441]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [332]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [297]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-A2 (CCNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [442]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [364]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [309]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [433]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [443]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [444]
Methotrexate DM2TEOL Anterior urethra cancer Approved [229]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [368]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [445]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon-induced GTP-binding protein Mx2 (MX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [302]
Testosterone enanthate DMB6871 N. A. N. A. Approved [132]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [446]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [374]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [239]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [447]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin alpha-X (ITGAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [448]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [449]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [450]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [324]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [451]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [452]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [453]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [453]
Ardeparin DMYRX8B Deep vein thrombosis BD71 Approved [454]
Bryostatin-1 DM1JOXY Alzheimer disease 8A20 Phase 2 [455]
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Drug(s) Affected By Myelin and lymphocyte protein (MAL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [456]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [254]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [456]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [457]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [458]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [459]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [460]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [461]
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Drug(s) Affected By Glutathione peroxidase 3 (GPX3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [462]
Selenium DM25CGV N. A. N. A. Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [463]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [464]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [465]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [466]
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Drug(s) Affected By 5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [270]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [270]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [263]
CATECHOL DML0YEK Discovery agent N.A. Investigative [467]
Butanoic Acid DMTAJP7 Discovery agent N.A. Investigative [218]
Protoporphyrin IX DMWYE7A Discovery agent N.A. Investigative [468]
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Drug(s) Affected By Receptor-type tyrosine-protein phosphatase delta (PTPRD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [324]
Testosterone enanthate DMB6871 N. A. N. A. Approved [132]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [149]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Trans-acting T-cell-specific transcription factor GATA-3 (GATA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Methotrexate DM2TEOL Anterior urethra cancer Approved [428]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [456]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [401]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [469]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [470]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [324]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [471]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adenomatous polyposis coli protein (APC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [310]
Selenium DM25CGV N. A. N. A. Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [472]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [473]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Folic Acid DMEMBJC Colorectal carcinoma Approved [474]
Menthol DMG2KW7 Back pain ME84.Z Approved [256]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
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Drug(s) Affected By Retinoblastoma-like protein 1 (RBL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [267]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [475]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Quercetin DM3NC4M Obesity 5B81 Approved [472]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [476]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [477]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By AT-rich interactive domain-containing protein 4A (ARID4A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [244]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [473]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Menthol DMG2KW7 Back pain ME84.Z Approved [256]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [479]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [480]
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Drug(s) Affected By M-phase inducer phosphatase 2 (CDC25B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [267]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [293]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [481]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [482]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ethanol DMDRQZU Chronic pain MG30 Approved [483]
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Drug(s) Affected By Syndecan-4 (SDC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [484]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [233]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [485]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [486]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [487]
Epanova DMHEAGL Hypertriglyceridemia 5C80.1 Approved [488]
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Drug(s) Affected By C-C chemokine receptor type 1 (CCR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [310]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
Testosterone enanthate DMB6871 N. A. N. A. Approved [132]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
Arsenic DMTL2Y1 N. A. N. A. Approved [489]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [230]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [490]
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Drug(s) Affected By G-protein coupled receptor 183 (GPR183)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [428]
Panobinostat DM58WKG Chronic graft versus host disease Approved [440]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [485]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [440]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [491]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [251]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [440]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [492]
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Drug(s) Affected By CD70 antigen (CD70)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [263]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [493]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [485]
Vemurafenib DM62UG5 Melanoma 2C30 Approved [494]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [495]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Menthol DMG2KW7 Back pain ME84.Z Approved [256]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [332]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By T-lymphocyte activation antigen CD80 (CD80)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [496]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [497]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [498]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [499]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [500]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [501]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [500]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [502]
Arsenic DMTL2Y1 N. A. N. A. Approved [336]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein kinase TTK (TTK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [267]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [274]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA replication licensing factor MCM4 (MCM4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [267]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [310]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [368]
Quercetin DM3NC4M Obesity 5B81 Approved [472]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [503]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Replication factor C subunit 3 (RFC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [267]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [504]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [477]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [505]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-F (CCNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [506]
Quercetin DM3NC4M Obesity 5B81 Approved [369]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [295]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [476]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [507]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor ETV6 (ETV6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [508]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [509]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [508]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [508]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [510]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [511]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA mismatch repair protein Msh2 (MSH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [267]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [512]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [295]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [513]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [505]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hydroxycarboxylic acid receptor 3 (HCAR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Vitamin B3 DMQVRZH Chronic renal failure GB61.Z Approved [514]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [447]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [251]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [515]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [516]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Centromere protein F (CENPF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Methotrexate DM2TEOL Anterior urethra cancer Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [517]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-4 (CASP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [314]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [308]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [360]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [518]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [519]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [520]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [521]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 5-formyltetrahydrofolate cyclo-ligase (MTHFS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [261]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Protein Tob1 (TOB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [263]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [293]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [279]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [477]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [339]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [522]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C chemokine receptor type 6 (CCR6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [496]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Arsenic DMTL2Y1 N. A. N. A. Approved [336]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [523]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [524]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase Nek2 (NEK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [274]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [293]
Selenium DM25CGV N. A. N. A. Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase PLK1 (PLK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [267]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [433]
Methotrexate DM2TEOL Anterior urethra cancer Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [271]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [525]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein FosB (FOSB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [432]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [486]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [526]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [456]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [287]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [392]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By UV excision repair protein RAD23 homolog B (RAD23B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Menthol DMG2KW7 Back pain ME84.Z Approved [256]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [527]
Indomethacin DMSC4A7 Bursitis Approved [250]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [227]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [528]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sestrin-2 (SESN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [432]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [318]
Methotrexate DM2TEOL Anterior urethra cancer Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [471]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [297]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [471]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [507]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [432]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neutrophil defensin 1 (DEFA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [529]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [530]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [531]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [531]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
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Drug(s) Affected By Ras-related C3 botulinum toxin substrate 3 (RAC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [532]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [385]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
Isoflavone DM7U58J N. A. N. A. Phase 4 [533]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [534]
Selenium DM25CGV N. A. N. A. Approved [320]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [317]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [535]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [317]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [317]
Trihexyphenidyl DMB19L8 Dystonia 8A02 Approved [317]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [317]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [314]
Flucytosine DM13VTW Cryptococcal meningitis Approved [536]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [536]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [537]
Methotrexate DM2TEOL Anterior urethra cancer Approved [367]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [538]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [539]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [297]
Amifostine DM5FL14 Mucositis CA00 Approved [540]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Runt-related transcription factor 1 (RUNX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [263]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [541]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [541]
Cotinine DMCEZ1B Insecticide N.A. Approved [542]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Spi-B (SPIB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Arsenic DMTL2Y1 N. A. N. A. Approved [543]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [544]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [545]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
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Drug(s) Affected By Myocyte-specific enhancer factor 2B (MEF2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [535]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [546]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [547]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [548]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [235]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By DNA-binding protein inhibitor ID-2 (ID2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [218]
Selenium DM25CGV N. A. N. A. Approved [149]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [549]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [463]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [550]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [471]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [297]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [485]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [549]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 2 (DUSP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Methotrexate DM2TEOL Anterior urethra cancer Approved [428]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [551]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [552]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Epanova DMHEAGL Hypertriglyceridemia 5C80.1 Approved [488]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [553]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [554]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [485]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [153]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [555]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [257]
Roflumilast DMPGHY8 Asthma CA23 Approved [556]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Regulator of G-protein signaling 1 (RGS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [428]
Quercetin DM3NC4M Obesity 5B81 Approved [557]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [324]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [558]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [491]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [559]
Arsenic DMTL2Y1 N. A. N. A. Approved [560]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dystrophia myotonica WD repeat-containing protein (DMWD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [495]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [417]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [561]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
PMID27336223-Compound-5 DM6E50A N. A. N. A. Patented [417]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone acetyltransferase p300 (EP300)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [562]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [563]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [552]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Menthol DMG2KW7 Back pain ME84.Z Approved [256]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [564]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [565]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dihydropyrimidine dehydrogenase (DPYD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [566]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [567]
Tegafur DM31ZQM Solid tumour/cancer 2A00-2F9Z Approved [568]
Flucytosine DM13VTW Cryptococcal meningitis Approved [173]
Selenium DM25CGV N. A. N. A. Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [463]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [380]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 13 (PTPN13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Menthol DMG2KW7 Back pain ME84.Z Approved [256]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [569]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [570]
Paclitaxel DMLB81S Breast carcinoma Approved [19]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [19]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [571]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho GTPase-activating protein 5 (ARHGAP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [431]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By MAL-like protein (MALL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
Folic Acid DMEMBJC Colorectal carcinoma Approved [572]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [505]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [573]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [574]
Seocalcitol DMKL9QO Rickets 5B57 Phase 3 [575]
Afimoxifene DMFORDT Breast cancer 2C60-2C65 Phase 2 [576]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [577]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TNF receptor-associated factor 1 (TRAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [578]
Methotrexate DM2TEOL Anterior urethra cancer Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [551]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [324]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Folic Acid DMEMBJC Colorectal carcinoma Approved [416]
Menthol DMG2KW7 Back pain ME84.Z Approved [256]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [267]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [274]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [368]
Quercetin DM3NC4M Obesity 5B81 Approved [557]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [333]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 5 activator 2 (CDK5R2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Folic Acid DMEMBJC Colorectal carcinoma Approved [579]
Menthol DMG2KW7 Back pain ME84.Z Approved [256]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Centromere protein R (ITGB3BP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [368]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [296]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [505]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [580]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [263]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [574]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [479]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [581]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [432]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [291]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [277]
Methotrexate DM2TEOL Anterior urethra cancer Approved [422]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [532]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [582]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [436]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [583]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [297]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Krueppel-like factor 9 (KLF9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [361]
Selenium DM25CGV N. A. N. A. Approved [149]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [549]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [535]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [549]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [549]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [584]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 13 (CDK13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [244]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Menthol DMG2KW7 Back pain ME84.Z Approved [256]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [585]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [586]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [149]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein Tob2 (TOB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [374]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [149]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [131]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase 38 (STK38)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [263]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Testosterone enanthate DMB6871 N. A. N. A. Approved [132]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [587]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinoblastoma-binding protein 5 (RBBP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone enanthate DMB6871 N. A. N. A. Approved [132]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Ethanol DMDRQZU Chronic pain MG30 Approved [588]
Menthol DMG2KW7 Back pain ME84.Z Approved [256]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [589]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [239]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor tyrosine-protein kinase erbB-4 (ERBB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [590]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [591]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [221]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [592]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [593]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [594]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Ampicillin DMHWE7P Acute epiglottitis Approved [128]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [523]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [523]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [595]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [271]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [596]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Menthol DMG2KW7 Back pain ME84.Z Approved [256]
Hesperidin DMI5DW1 Vascular purpura 3B60 Approved [597]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor coactivator 1 (NCOA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [323]
Quercetin DM3NC4M Obesity 5B81 Approved [557]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [598]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [599]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [600]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tubulin-specific chaperone C (TBCC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 3 (CDKN3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [267]
Methotrexate DM2TEOL Anterior urethra cancer Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [296]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [128]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor-type tyrosine-protein phosphatase-like N (PTPRN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [601]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [324]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [385]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [230]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [243]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By B-cell CLL/lymphoma 7 protein family member A (BCL7A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Bortezomib DMNO38U Leukemia Approved [339]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [230]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [243]
Milchsaure DM462BT Pruritus EC90 Investigative [602]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Transmembrane protein 41B (TMEM41B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Bortezomib DMNO38U Leukemia Approved [339]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [586]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [134]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription initiation factor TFIID subunit 2 (TAF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Selenium DM25CGV N. A. N. A. Approved [149]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
Milchsaure DM462BT Pruritus EC90 Investigative [602]
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Drug(s) Affected By DNA cross-link repair 1A protein (DCLRE1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [603]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [480]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [599]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-myc promoter-binding protein (DENND4A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Bortezomib DMNO38U Leukemia Approved [339]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [19]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [149]
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Drug(s) Affected By COMM domain-containing protein 6 (COMMD6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [459]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [243]
Milchsaure DM462BT Pruritus EC90 Investigative [602]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [604]
chloropicrin DMSGBQA Discovery agent N.A. Investigative [605]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Bone morphogenetic protein 8A (BMP8A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [557]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [606]
Drug(s) Affected By Pleckstrin homology domain-containing family H member 3 (PLEKHH3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [263]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [607]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [608]
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Drug(s) Affected By DNA damage-binding protein 2 (DDB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [609]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [541]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [541]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [128]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [252]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [254]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [584]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Mestranol DMG3F94 Contraception QA21 Approved [252]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [252]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [227]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H2A type 1-C (H2AC6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [557]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [234]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [610]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aurora kinase B (AURKB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [148]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [274]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [433]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [611]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [271]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [541]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sorting nexin-18 (SNX18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [385]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [612]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [613]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [221]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Oncostatin-M-specific receptor subunit beta (OSMR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [261]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [573]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Gefitinib DM15F0X Colon adenocarcinoma Approved [614]
Paclitaxel DMLB81S Breast carcinoma Approved [19]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 5 (MAP3K5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [463]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [615]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [616]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [617]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [618]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [619]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Growth/differentiation factor 15 (GDF15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [432]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [433]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [620]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [279]
Quercetin DM3NC4M Obesity 5B81 Approved [557]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [621]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [347]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [347]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [622]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [623]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ubiquitin-like-conjugating enzyme ATG10 (ATG10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [251]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [624]
AT7519 DMCE08M Solid tumour/cancer 2A00-2F9Z Phase 1 [625]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [515]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [269]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase PLK3 (PLK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [263]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [541]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [541]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [553]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase Topors (TOPORS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [480]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [243]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [244]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase PLK2 (PLK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [626]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [374]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Gamma-adducin (ADD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [361]
Selenium DM25CGV N. A. N. A. Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [504]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [374]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [627]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Targeting protein for Xklp2 (TPX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [271]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [272]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protocadherin gamma-C3 (PCDHGC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [628]
Selenium DM25CGV N. A. N. A. Approved [149]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [385]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [629]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [149]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 22 (PTPN22)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [361]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [473]
Folic Acid DMEMBJC Colorectal carcinoma Approved [630]
Capsaicin DMGMF6V Back pain ME84.Z Approved [631]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [239]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [585]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [490]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [473]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [632]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [149]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase Sgk1 (SGK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [252]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [633]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [634]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [620]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [471]
Estrone DM5T6US Acne vulgaris ED80 Approved [252]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [635]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Matrilin-2 (MATN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [271]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [636]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [298]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [332]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [447]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [573]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Krev interaction trapped protein 1 (KRIT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Folic Acid DMEMBJC Colorectal carcinoma Approved [579]
Bortezomib DMNO38U Leukemia Approved [339]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [637]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [638]
taurine DMVW7N3 Discovery agent N.A. Investigative [639]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proepiregulin (EREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [267]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [317]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [317]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [317]
Methotrexate DM2TEOL Anterior urethra cancer Approved [367]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [640]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [317]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calmegin (CLGN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [641]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [641]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [296]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [473]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [293]
Quercetin DM3NC4M Obesity 5B81 Approved [557]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [493]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [642]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [391]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Centrosomal protein of 290 kDa (CEP290)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [473]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Bortezomib DMNO38U Leukemia Approved [339]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [149]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (ANKRD28)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [643]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [554]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [134]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By FYN-binding protein 1 (FYB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [428]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [644]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [645]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [485]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [447]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [230]
Mivebresib DMCPF90 Acute myeloid leukaemia 2A60 Phase 1 [646]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
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Drug(s) Affected By Protein phosphatase 1D (PPM1D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [647]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [433]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [277]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [620]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [648]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [507]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [541]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [218]
Fluoxetine DM3PD2C Bipolar depression Approved [649]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [332]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [493]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [650]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [493]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [486]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [541]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Krueppel-like factor 4 (KLF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [432]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [271]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [651]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [652]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [432]
Testosterone DM7HUNW Hot flushes GA30 Approved [653]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [552]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Density-regulated protein (DENR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [293]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [134]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [654]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase MARCHF6 (MARCHF6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [655]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Betaine DMGRZW2 Cystitis GC00 Approved [655]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [149]
ANW-32821 DMMJOZD N. A. N. A. Phase 2 [655]
CB-5083 DM12GN7 Multiple myeloma 2A83 Phase 1 [655]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Oligophrenin-1 (OPHN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [385]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [637]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [447]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [613]
Milchsaure DM462BT Pruritus EC90 Investigative [602]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NEDD4-binding protein 1 (N4BP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [485]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [221]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [599]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [149]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [243]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [244]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ankyrin repeat domain-containing protein 17 (ANKRD17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [251]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [230]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [656]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [244]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [263]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor corepressor 1 (NCOR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [657]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [323]
Quercetin DM3NC4M Obesity 5B81 Approved [244]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [658]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [552]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [323]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Death effector domain-containing protein (DEDD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [659]
Paclitaxel DMLB81S Breast carcinoma Approved [660]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [385]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [523]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [149]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [603]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [523]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutaredoxin-3 (GLRX3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Benzatropine DMF7EXL Parkinsonian disorder Approved [373]
Clozapine DMFC71L Schizophrenia 6A20 Approved [373]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [339]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tubulin polymerization-promoting protein (TPPP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [257]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [209]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [577]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [661]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [604]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Protein transport protein Sec31A (SEC31A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [244]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [234]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Clozapine DMFC71L Schizophrenia 6A20 Approved [373]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
Arsenic DMTL2Y1 N. A. N. A. Approved [662]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By SR-related and CTD-associated factor 4 (SCAF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [251]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [149]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [663]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [290]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [221]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Reversion-inducing cysteine-rich protein with Kazal motifs (RECK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [153]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [664]
Folic Acid DMEMBJC Colorectal carcinoma Approved [579]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [505]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tissue-type plasminogen activator (PLAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [534]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [665]
Etretinate DM2CZFA Keratosis ED56 Approved [666]
Prednisone DM2HG4X Acute asthma CA23 Approved [667]
Methotrexate DM2TEOL Anterior urethra cancer Approved [367]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [668]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [669]
Fructose DM43AN2 Vomiting MD90 Approved [670]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [347]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Angiotensinogen (AGT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [671]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [672]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [673]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [674]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [675]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [676]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [677]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [678]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By HLA class I histocompatibility antigen, B alpha chain (HLA-B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [679]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [680]
Allopurinol DMLPAOB Gout FA25 Approved [681]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [447]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [682]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [683]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [684]
Flucloxacillin DMNUWST Bacterial infection 1A00-1C4Z Approved [685]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [686]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [683]
Clindamycin DM15HL8 Acne vulgaris ED80 Approved [683]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [683]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Cefepime DMHVWIK Bacterial infection 1A00-1C4Z Approved [683]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [687]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [683]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myelin basic protein (MBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [428]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [688]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [643]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Clozapine DMFC71L Schizophrenia 6A20 Approved [689]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [374]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibronectin (FN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [690]
Methotrexate DM2TEOL Anterior urethra cancer Approved [428]
Quercetin DM3NC4M Obesity 5B81 Approved [557]
Aripiprazole DM3NUMH Bipolar I disorder Approved [691]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [692]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [693]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Ethacrynic acid DM60QMR Edema MG29 Approved [694]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [695]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [596]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [173]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [696]
Diazepam DM08E9O Alcohol withdrawal Approved [697]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [698]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [345]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [699]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [700]
Methotrexate DM2TEOL Anterior urethra cancer Approved [701]
Quercetin DM3NC4M Obesity 5B81 Approved [702]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transferrin receptor protein 1 (TFRC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [360]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [703]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [704]
Quercetin DM3NC4M Obesity 5B81 Approved [601]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [456]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [504]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [297]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [449]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [705]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-enolase (ENO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [706]
Etretinate DM2CZFA Keratosis ED56 Approved [707]
Methotrexate DM2TEOL Anterior urethra cancer Approved [176]
Quercetin DM3NC4M Obesity 5B81 Approved [708]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [463]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [297]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [709]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [234]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [541]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Sp1 (SP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [173]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [710]
Quercetin DM3NC4M Obesity 5B81 Approved [711]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [692]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [712]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [713]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [710]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [714]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [715]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [601]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Tetracaine DM9J6C2 Spinal anesthesia MB40.3 Approved [716]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [154]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By U2 small nuclear ribonucleoprotein A' (SNRPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [430]
Paclitaxel DMLB81S Breast carcinoma Approved [460]
Topotecan DMP6G8T Central nervous system neoplasm Approved [460]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [717]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [718]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [599]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon alpha-inducible protein 6 (IFI6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [314]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [569]
Gefitinib DM15F0X Colon adenocarcinoma Approved [719]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [218]
Selenium DM25CGV N. A. N. A. Approved [149]
Methotrexate DM2TEOL Anterior urethra cancer Approved [641]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [493]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [641]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [153]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Chorionic somatomammotropin hormone 2 (CSH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Forskolin DM6ITNG Solid tumour/cancer 2A00-2F9Z Investigative [720]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [235]
Drug(s) Affected By Tissue factor pathway inhibitor (TFPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [252]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Estrone DM5T6US Acne vulgaris ED80 Approved [252]
Testosterone DM7HUNW Hot flushes GA30 Approved [721]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Ethanol DMDRQZU Chronic pain MG30 Approved [722]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Breakpoint cluster region protein (BCR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [369]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [723]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [724]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Folic Acid DMEMBJC Colorectal carcinoma Approved [579]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [725]
Bortezomib DMNO38U Leukemia Approved [339]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon-induced transmembrane protein 1 (IFITM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Selenium DM25CGV N. A. N. A. Approved [149]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [529]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [153]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [324]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By HLA class II histocompatibility antigen, DR beta 4 chain (HLA-DRB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Arsenic DMTL2Y1 N. A. N. A. Approved [543]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [726]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [717]
QUERCITRIN DM1DH96 Discovery agent N.A. Investigative [727]
Milchsaure DM462BT Pruritus EC90 Investigative [602]
Manganese DMKT129 N. A. N. A. Investigative [728]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [541]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [729]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [462]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [318]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [730]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [731]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [732]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [733]
Quercetin DM3NC4M Obesity 5B81 Approved [734]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [456]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Arylsulfatase B (ARSB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [477]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [393]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
Chondroitin sulfate DM0N19Y N. A. N. A. Phase 4 [735]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [263]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [269]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Carboxypeptidase E (CPE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [263]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [535]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ethanol DMDRQZU Chronic pain MG30 Approved [722]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin alpha-2 (ITGA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [534]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [279]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [736]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [737]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Gap junction alpha-1 protein (GJA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [738]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [485]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [530]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Folic Acid DMEMBJC Colorectal carcinoma Approved [572]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [739]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [738]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [740]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [741]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peptidyl-glycine alpha-amidating monooxygenase (PAM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [227]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [573]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [492]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [173]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione hydrolase 1 proenzyme (GGT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [173]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [742]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Arsenic DMTL2Y1 N. A. N. A. Approved [543]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [173]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [230]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras GTPase-activating protein 1 (RASA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [456]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Folic Acid DMEMBJC Colorectal carcinoma Approved [416]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [270]
Arsenic DMTL2Y1 N. A. N. A. Approved [743]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Synaptotagmin-1 (SYT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Heroin diacetylmorphine DMDBWHY Neurological disorder 6B60 Approved [744]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Folic Acid DMEMBJC Colorectal carcinoma Approved [579]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [745]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [209]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor-type tyrosine-protein phosphatase gamma (PTPRG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [257]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [374]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Paired box protein Pax-7 (PAX7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [746]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [447]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [747]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [221]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [134]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [221]
Afimoxifene DMFORDT Breast cancer 2C60-2C65 Phase 2 [747]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Annexin A13 (ANXA13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Folic Acid DMEMBJC Colorectal carcinoma Approved [748]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [227]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [447]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [577]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [749]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Lens fiber major intrinsic protein (MIP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [750]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
Drug(s) Affected By Fibroblast growth factor 9 (FGF9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [751]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [505]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [752]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [753]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [221]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glycerol kinase (GK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [463]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [153]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [473]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [211]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [332]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [339]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [742]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cystathionine gamma-lyase (CTH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [432]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [218]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [297]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [754]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [153]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [432]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [541]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myosin-10 (MYH10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [755]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [312]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [756]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [584]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [505]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Large ribosomal subunit protein uL4 (RPL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [757]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [758]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [759]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [760]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [480]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [613]
Milchsaure DM462BT Pruritus EC90 Investigative [602]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By T-complex protein 1 subunit zeta (CCT6A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [373]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [761]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Aminoglutethimide DMWFHMZ Cushing disease 5A70 Approved [762]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [760]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Reduced folate transporter (SLC19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [763]
Methotrexate DM2TEOL Anterior urethra cancer Approved [764]
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [764]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Selenium DM25CGV N. A. N. A. Approved [149]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [765]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ethanol DMDRQZU Chronic pain MG30 Approved [765]
Atenolol DMNKG1Z Angina pectoris BA40 Approved [765]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Matrin-3 (MATR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [647]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [647]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [221]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [766]
ACYLINE DM9GRTK Prostate cancer 2C82.0 Phase 2 [767]
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Drug(s) Affected By Transcriptional regulator ATRX (ATRX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [361]
Selenium DM25CGV N. A. N. A. Approved [149]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [746]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Testosterone enanthate DMB6871 N. A. N. A. Approved [132]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [473]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Ethanol DMDRQZU Chronic pain MG30 Approved [722]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Vesicle-fusing ATPase (NSF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Haloperidol DM96SE0 Delirium Approved [373]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Benzatropine DMF7EXL Parkinsonian disorder Approved [373]
Clozapine DMFC71L Schizophrenia 6A20 Approved [373]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [768]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stromal cell-derived factor 1 (CXCL12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [628]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [252]
Methotrexate DM2TEOL Anterior urethra cancer Approved [428]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [769]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Estrone DM5T6US Acne vulgaris ED80 Approved [252]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [770]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [771]
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Drug(s) Affected By Nuclear pore complex protein Nup153 (NUP153)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [263]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [244]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [772]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Benzatropine DMF7EXL Parkinsonian disorder Approved [373]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Gastrotropin (FABP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [773]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [221]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [774]
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [775]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [447]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [459]
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Drug(s) Affected By Host cell factor 1 (HCFC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [293]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [776]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [459]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [776]
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Drug(s) Affected By Collagen alpha-4(IV) chain (COL4A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [777]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [221]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [778]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [779]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [263]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [235]
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Drug(s) Affected By Coatomer subunit alpha (COPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [656]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [607]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [244]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [263]
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Drug(s) Affected By Cadherin-4 (CDH4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [780]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [257]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [173]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
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Drug(s) Affected By C-terminal-binding protein 2 (CTBP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Pyruvic acid DM7Q41G Malnutrition 5B50-5B71 Approved [781]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [552]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [270]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [227]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [270]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ADP-ribosylation factor-like protein 4C (ARL4C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [782]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [324]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [495]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Folic Acid DMEMBJC Colorectal carcinoma Approved [572]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
Bortezomib DMNO38U Leukemia Approved [339]
Indomethacin DMSC4A7 Bursitis Approved [250]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Epiplakin (EPPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [324]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Folic Acid DMEMBJC Colorectal carcinoma Approved [579]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [447]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [632]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [251]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lysyl oxidase homolog 3 (LOXL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [477]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [257]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [374]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [251]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [134]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [511]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [243]
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Drug(s) Affected By Histone H4 (H4C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [506]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [433]
Selenium DM25CGV N. A. N. A. Approved [149]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [279]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Panobinostat DM58WKG Chronic graft versus host disease Approved [783]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [380]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By AP-2 complex subunit beta (AP2B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [279]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Testosterone enanthate DMB6871 N. A. N. A. Approved [132]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [173]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hemoglobin subunit gamma-1 (HBG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone enanthate DMB6871 N. A. N. A. Approved [132]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [447]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [262]
2-tert-butylbenzene-1,4-diol DMNXI1E Discovery agent N.A. Investigative [784]
Drug(s) Affected By Mothers against decapentaplegic homolog 3 (SMAD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [263]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [785]
Quercetin DM3NC4M Obesity 5B81 Approved [562]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [437]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [786]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [552]
Ethanol DMDRQZU Chronic pain MG30 Approved [300]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [787]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ADP-ribosylation factor 1 (ARF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [237]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [788]
Josamycin DMKJ8LB Bacterial infection 1A00-1C4Z Approved [789]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [790]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [791]
Gefitinib DM15F0X Colon adenocarcinoma Approved [792]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [444]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Quercetin DM3NC4M Obesity 5B81 Approved [472]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [793]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Clathrin heavy chain 1 (CLTC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [758]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [794]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [134]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Centromere-associated protein E (CENPE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [218]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [272]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [505]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Paired box protein Pax-5 (PAX5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [360]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [477]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [630]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [795]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [221]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [545]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dystonin (DST)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [263]
Quercetin DM3NC4M Obesity 5B81 Approved [244]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [380]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [473]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Folic Acid DMEMBJC Colorectal carcinoma Approved [579]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Focal adhesion kinase 1 (PTK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [796]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [797]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [368]
Quercetin DM3NC4M Obesity 5B81 Approved [798]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [383]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [799]
Testosterone DM7HUNW Hot flushes GA30 Approved [800]
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [801]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Recombining binding protein suppressor of hairless (RBPJ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [263]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [564]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [802]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [453]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [453]
Arsenic DMTL2Y1 N. A. N. A. Approved [743]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [803]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [477]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Benzatropine DMF7EXL Parkinsonian disorder Approved [373]
Clozapine DMFC71L Schizophrenia 6A20 Approved [373]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [227]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein phosphatase 3 catalytic subunit alpha (PPP3CA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [529]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [804]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Benzatropine DMF7EXL Parkinsonian disorder Approved [373]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [805]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Leukocyte surface antigen CD47 (CD47)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [314]
Methotrexate DM2TEOL Anterior urethra cancer Approved [428]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transmembrane protein 267 (TMEM267)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [471]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [471]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [471]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [261]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [471]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proline-rich nuclear receptor coactivator 1 (PNRC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [504]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [471]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [257]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [627]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-globin transcription factor CP2 (TFCP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Isoflavone DM7U58J N. A. N. A. Phase 4 [806]
Milchsaure DM462BT Pruritus EC90 Investigative [602]
geraniol DMS3CBD Discovery agent N.A. Investigative [807]
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Drug(s) Affected By Disks large homolog 1 (DLG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [339]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase 4 (STK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Bortezomib DMNO38U Leukemia Approved [808]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [149]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [809]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [810]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [293]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [811]
Quercetin DM3NC4M Obesity 5B81 Approved [812]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [463]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [650]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [813]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [814]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [361]
Quercetin DM3NC4M Obesity 5B81 Approved [815]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [816]
Testosterone DM7HUNW Hot flushes GA30 Approved [817]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [818]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Capsaicin DMGMF6V Back pain ME84.Z Approved [631]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [819]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [509]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BMP and activin membrane-bound inhibitor homolog (BAMBI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [291]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [782]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [153]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dynactin subunit 2 (DCTN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Benzatropine DMF7EXL Parkinsonian disorder Approved [373]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [638]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Cullin-4A (CUL4A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [293]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [820]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [227]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [821]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Selenium DM25CGV N. A. N. A. Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [757]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [477]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Benzatropine DMF7EXL Parkinsonian disorder Approved [373]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Guanine nucleotide-binding protein subunit alpha-13 (GNA13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [293]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [270]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Disco-interacting protein 2 homolog A (DIP2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [263]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Testosterone enanthate DMB6871 N. A. N. A. Approved [132]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
Geldanamycin DMS7TC5 Kidney cancer 2C90.0 Discontinued in Phase 2 [298]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Uncharacterized protein KIAA0040 (KIAA0040)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [287]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [417]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [209]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [632]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [492]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kinesin-like protein KIF14 (KIF14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [279]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [477]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [272]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transforming growth factor-beta-induced protein ig-h3 (TGFBI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [822]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [374]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [823]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [573]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-G2 (CCNG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [252]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Fluoxetine DM3PD2C Bipolar depression Approved [471]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Estrone DM5T6US Acne vulgaris ED80 Approved [252]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [541]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [541]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By MICOS complex subunit MIC60 (IMMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [824]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [393]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [654]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [235]
[3H]methyltrienolone DMTSGOW Discovery agent N.A. Investigative [825]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By WD40 repeat-containing protein SMU1 (SMU1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
PMID28870136-Compound-48 DMPIM9L N. A. N. A. Patented [361]
Drug(s) Affected By Neuroblastoma breakpoint family member 1 (NBPF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [209]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [459]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [290]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cell adhesion molecule-related/down-regulated by oncogenes (CDON)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [342]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [221]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [134]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [492]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein LBH (LBH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [332]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [257]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Shugoshin 2 (SGO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Methotrexate DM2TEOL Anterior urethra cancer Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By PAN2-PAN3 deadenylation complex subunit PAN3 (PAN3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [243]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
Drug(s) Affected By Sterile alpha motif domain-containing protein 9 (SAMD9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [826]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [254]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [473]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [553]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein phosphatase 4 regulatory subunit 3B (PPP4R3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [827]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [243]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [263]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Acyl-coenzyme A thioesterase THEM4 (THEM4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [477]
Folic Acid DMEMBJC Colorectal carcinoma Approved [579]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [134]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [261]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [243]
Glyphosate DM0AFY7 Malaria 1F40-1F45 Investigative [828]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By MAGUK p55 subfamily member 7 (MPP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [324]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [473]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Folic Acid DMEMBJC Colorectal carcinoma Approved [579]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DDB1- and CUL4-associated factor 8 (DCAF8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [585]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [829]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [149]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [269]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Collagen alpha-1(XIII) chain (COL13A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [254]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [374]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [453]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [509]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [830]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Probable E3 ubiquitin-protein ligase HECTD2 (HECTD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Bortezomib DMNO38U Leukemia Approved [339]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [243]
OXYQUINOLINE DMZVS9Y Discovery agent N.A. Investigative [128]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase MRCK alpha (CDC42BPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [485]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [587]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho GTPase-activating protein SYDE2 (SYDE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [221]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [447]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [599]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Deubiquitinase MYSM1 (MYSM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [244]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [243]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [290]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By AT-rich interactive domain-containing protein 2 (ARID2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Panobinostat DM58WKG Chronic graft versus host disease Approved [831]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [339]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [447]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [832]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [480]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glucose 1,6-bisphosphate synthase (PGM2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [254]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [833]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By UPF0547 protein C16orf87 (C16ORF87)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [561]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [244]
Milchsaure DM462BT Pruritus EC90 Investigative [602]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [235]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Kelch-like protein 24 (KLHL24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Fluoxetine DM3PD2C Bipolar depression Approved [471]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
Testosterone enanthate DMB6871 N. A. N. A. Approved [132]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [471]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [380]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [453]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [509]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho-related GTP-binding protein RhoU (RHOU)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Methotrexate DM2TEOL Anterior urethra cancer Approved [367]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [829]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [553]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [453]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [453]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein ABHD13 (ABHD13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [261]
Folic Acid DMEMBJC Colorectal carcinoma Approved [579]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [221]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [361]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Diphthine--ammonia ligase (DPH6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [515]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [263]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Pogo transposable element with ZNF domain (POGZ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [244]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [480]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [244]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By FERM domain-containing protein 5 (FRMD5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [385]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [447]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylinositol-glycan biosynthesis class W protein (PIGW)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [257]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [453]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [453]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amphoterin-induced protein 2 (AMIGO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [641]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [641]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [505]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [641]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [641]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dihydrofolate reductase 2, mitochondrial (DHFR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [235]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [834]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [243]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ELKS/Rab6-interacting/CAST family member 1 (ERC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Testosterone enanthate DMB6871 N. A. N. A. Approved [132]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [465]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [453]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [453]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [261]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [511]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Armadillo repeat-containing protein 8 (ARMC8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [515]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [279]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Bortezomib DMNO38U Leukemia Approved [339]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [459]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [515]
Glyphosate DM0AFY7 Malaria 1F40-1F45 Investigative [828]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [290]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein FAM219A (FAM219A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Bortezomib DMNO38U Leukemia Approved [339]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [209]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [131]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [128]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [244]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Homeobox protein Mohawk (MKX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [632]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [459]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [511]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [480]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [835]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [235]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Threonine synthase-like 1 (THNSL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [428]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [153]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Testosterone enanthate DMB6871 N. A. N. A. Approved [132]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [553]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Porimin (TMEM123)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [515]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [243]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [548]
chloropicrin DMSGBQA Discovery agent N.A. Investigative [605]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Rho guanine nucleotide exchange factor 39 (ARHGEF39)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [128]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [477]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [209]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [511]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [836]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Type 2 DNA topoisomerase 6 subunit B-like (TOP6BL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [492]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [243]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [235]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [137]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein SCAI (SCAI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [837]
Drug(s) Affected By Diacylglycerol lipase-beta (DAGLB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [148]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Clozapine DMFC71L Schizophrenia 6A20 Approved [838]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [209]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [134]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Regulator of G-protein signaling 22 (RGS22)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [839]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [749]
Drug(s) Affected By Phospholipase DDHD1 (DDHD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [251]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [840]
Milchsaure DM462BT Pruritus EC90 Investigative [602]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [269]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lysophosphatidylcholine acyltransferase 1 (LPCAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [134]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [460]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [515]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [841]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Biorientation of chromosomes in cell division protein 1-like 1 (BOD1L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [298]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [473]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [298]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
Geldanamycin DMS7TC5 Kidney cancer 2C90.0 Discontinued in Phase 2 [298]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [244]
methyl p-hydroxybenzoate DMO58UW Discovery agent N.A. Investigative [842]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Atlastin-2 (ATL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [134]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Centrosomal protein of 192 kDa (CEP192)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [289]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [515]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [599]
KOJIC ACID DMP84CS Discovery agent N.A. Investigative [843]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DEP domain-containing protein 1B (DEPDC1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [261]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [272]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [505]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pleckstrin homology-like domain family A member 1 (PHLDA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [506]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [153]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
Testosterone enanthate DMB6871 N. A. N. A. Approved [132]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Microprocessor complex subunit DGCR8 (DGCR8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [506]
Selenium DM25CGV N. A. N. A. Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [380]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [257]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [844]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [480]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tribbles homolog 2 (TRIB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [437]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [739]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [632]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [342]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein FAM3C (FAM3C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [347]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [347]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [209]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [460]
Paclitaxel DMLB81S Breast carcinoma Approved [460]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CREB-binding protein (CREBBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [369]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [563]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [279]
Testosterone DM7HUNW Hot flushes GA30 Approved [845]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [552]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [564]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [565]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [553]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone acetyltransferase KAT2B (KAT2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [367]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [563]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [564]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [598]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein DLX-4 (DLX4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [628]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [746]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [380]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [846]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [251]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein tyrosine phosphatase type IVA 1 (PTP4A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [620]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [623]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [374]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [620]
Arsenic DMTL2Y1 N. A. N. A. Approved [847]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor protein p53-inducible nuclear protein 1 (TP53INP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Methotrexate DM2TEOL Anterior urethra cancer Approved [367]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [848]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [507]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [541]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [541]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [541]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Exocyst complex component 4 (EXOC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [515]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [841]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RalBP1-associated Eps domain-containing protein 1 (REPS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [153]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [134]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [849]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [850]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein LTV1 homolog (LTV1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [227]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [251]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [603]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [244]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By PDZ and LIM domain protein 5 (PDLIM5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [361]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Haloperidol DM96SE0 Delirium Approved [373]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Folic Acid DMEMBJC Colorectal carcinoma Approved [579]
Benzatropine DMF7EXL Parkinsonian disorder Approved [373]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DISP complex protein LRCH3 (LRCH3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [447]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [827]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [131]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [661]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [290]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Rho GTPase-activating protein 7 (DLC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [302]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [851]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [852]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tribbles homolog 1 (TRIB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [506]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [153]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitochondrial inner membrane protease subunit 2 (IMMP2L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [134]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [263]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [269]
AM251 DMTAWHL Discovery agent N.A. Investigative [853]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Transcription factor 12 (TCF12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Methotrexate DM2TEOL Anterior urethra cancer Approved [428]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [583]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [583]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [552]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP synthase subunit s, mitochondrial (DMAC2L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [287]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [565]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [854]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [221]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [243]
PMID28870136-Compound-48 DMPIM9L N. A. N. A. Patented [361]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [607]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Semaphorin-3C (SEMA3C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [263]
Quercetin DM3NC4M Obesity 5B81 Approved [826]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [855]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [473]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (DPH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [459]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Mitochondrial 2-oxodicarboxylate carrier (SLC25A21)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [287]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [251]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [261]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [261]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [131]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [243]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [856]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Deubiquitinase DESI2 (DESI2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [504]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Testosterone enanthate DMB6871 N. A. N. A. Approved [132]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [227]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Acireductone dioxygenase (ADI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Dutasteride DMQ4TJK Benign prostatic hyperplasia GA90 Approved [857]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [453]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [453]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein C1orf43 (C1ORF43)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [361]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [858]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Bortezomib DMNO38U Leukemia Approved [339]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [243]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [548]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [604]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By RNA-binding protein 24 (RBM24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [324]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [289]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [859]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [860]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleolar and spindle-associated protein 1 (NUSAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [271]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [234]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase TRIM9 (TRIM9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [209]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [861]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [221]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [778]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [134]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase TRIM4 (TRIM4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [263]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [453]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [509]
GSK2110183 DMZHB37 leukaemia 2A60-2B33 Phase 2 [862]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone-lysine N-methyltransferase SETD5 (SETD5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Folic Acid DMEMBJC Colorectal carcinoma Approved [579]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [546]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [863]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-ketoglutarate-dependent dioxygenase FTO (FTO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [757]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [509]
Arsenic DMTL2Y1 N. A. N. A. Approved [864]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [480]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [131]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [244]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Centrosomal protein of 295 kDa (CEP295)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [339]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [480]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [243]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Sentrin-specific protease 6 (SENP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [831]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [473]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [865]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [831]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [480]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [515]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome c oxidase assembly factor 1 homolog (COA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [453]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [453]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [827]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [866]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [134]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [480]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [453]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [221]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [835]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [604]
NAPQI DM8F5LR Autoimmune disease 4A40-4A45 Investigative [867]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metal transporter CNNM2 (CNNM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [505]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [553]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [385]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pleckstrin homology domain-containing family A member 5 (PLEKHA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Selenium DM25CGV N. A. N. A. Approved [149]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [554]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [393]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [573]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase SMURF1 (SMURF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [209]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [868]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [869]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [269]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Large ribosomal subunit protein mL65 (MRPS30)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [393]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Transcription factor 7-like 2 (TCF7L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [282]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [552]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [553]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
Bortezomib DMNO38U Leukemia Approved [870]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Muscleblind-like protein 1 (MBNL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Bortezomib DMNO38U Leukemia Approved [339]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Indomethacin DMSC4A7 Bursitis Approved [250]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [871]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lymphoid-specific helicase (HELLS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [505]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phenylalanine--tRNA ligase beta subunit (FARSB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Clozapine DMFC71L Schizophrenia 6A20 Approved [373]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [227]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [251]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Midasin (MDN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [244]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [459]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [230]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By tRNA:m(4)X modification enzyme TRM13 homolog (TRMT13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [373]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [263]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [584]
Haloperidol DM96SE0 Delirium Approved [373]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [251]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase RLIM (RLIM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [131]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [149]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [290]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [235]
RESORCINOL DMM37C0 Discovery agent N.A. Investigative [289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G patch domain-containing protein 2-like (GPATCH2L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Bortezomib DMNO38U Leukemia Approved [339]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [511]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [486]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Benzatropine DMF7EXL Parkinsonian disorder Approved [373]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [554]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Huntingtin-interacting protein K (HYPK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [718]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [599]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Inhibitor of growth protein 3 (ING3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [526]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Arsenic DMTL2Y1 N. A. N. A. Approved [872]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [261]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [296]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [480]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho guanine nucleotide exchange factor 12 (ARHGEF12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [134]
Arsenic DMTL2Y1 N. A. N. A. Approved [543]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [244]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [263]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [604]
Hexadecanoic acid DMWUXDZ Discovery agent N.A. Investigative [873]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cysteine-rich motor neuron 1 protein (CRIM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [782]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
Testosterone enanthate DMB6871 N. A. N. A. Approved [132]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [471]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
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Drug(s) Affected By Voltage-dependent T-type calcium channel subunit alpha-1I (CACNA1I)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [459]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [459]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [263]
Drug(s) Affected By eIF-2-alpha kinase GCN2 (EIF2AK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [293]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [270]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [794]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [270]
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Drug(s) Affected By DNA polymerase kappa (POLK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [473]
Paclitaxel DMLB81S Breast carcinoma Approved [660]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Guanine DMIWLJE N. A. N. A. Phase 3 [874]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [480]
MK-886 DMT0O7H Asthma CA23 Discontinued in Phase 2 [875]
680C91 DMCDTIG Solid tumour/cancer 2A00-2F9Z Preclinical [876]
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Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 13 (MED13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [244]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [270]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [270]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [656]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
Geldanamycin DMS7TC5 Kidney cancer 2C90.0 Discontinued in Phase 2 [298]
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Drug(s) Affected By Jupiter microtubule associated homolog 1 (JPT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [380]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
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Drug(s) Affected By BTB/POZ domain-containing protein 3 (BTBD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [782]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Arsenic DMTL2Y1 N. A. N. A. Approved [743]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [342]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [866]
Methotrexate DM2TEOL Anterior urethra cancer Approved [460]
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Drug(s) Affected By Thyroid hormone receptor-associated protein 3 (THRAP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Clozapine DMFC71L Schizophrenia 6A20 Approved [373]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [829]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [480]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [243]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
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Drug(s) Affected By rRNA-processing protein FCF1 homolog (FCF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [599]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [261]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [841]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [599]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [269]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMHD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [374]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [447]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [546]
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Drug(s) Affected By Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (HS3ST3B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [339]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [350]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [251]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [624]
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Drug(s) Affected By Calcineurin-binding protein cabin-1 (CABIN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [877]
Selenium DM25CGV N. A. N. A. Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [601]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [739]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [515]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proton-coupled zinc antiporter SLC30A1 (SLC30A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [506]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [279]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [878]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [178]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [297]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [298]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [267]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [433]
Methotrexate DM2TEOL Anterior urethra cancer Approved [879]
Quercetin DM3NC4M Obesity 5B81 Approved [472]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [880]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [881]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [882]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [883]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [628]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [884]
Methotrexate DM2TEOL Anterior urethra cancer Approved [411]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [885]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [886]
Quercetin DM3NC4M Obesity 5B81 Approved [472]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [283]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [887]
Ethacrynic acid DM60QMR Edema MG29 Approved [888]
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Drug(s) Affected By Ubiquinone biosynthesis protein COQ9, mitochondrial (COQ9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [889]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [211]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Folic Acid DMEMBJC Colorectal carcinoma Approved [579]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [149]
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Drug(s) Affected By Interleukin-33 (IL33)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [153]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [324]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [553]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [890]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [357]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [891]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [892]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [893]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [894]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [267]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [895]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [881]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [380]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [414]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Capsaicin DMGMF6V Back pain ME84.Z Approved [896]
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Drug(s) Affected By Superoxide dismutase (SOD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [897]
Haloperidol DM96SE0 Delirium Approved [173]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [628]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [360]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [318]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [898]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [899]
Methotrexate DM2TEOL Anterior urethra cancer Approved [900]
Epinephrine DM3KJBC Acute asthma CA23 Approved [901]
Quercetin DM3NC4M Obesity 5B81 Approved [902]
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Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [438]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Quercetin DM3NC4M Obesity 5B81 Approved [903]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [438]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [904]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [905]
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Drug(s) Affected By Protransforming growth factor alpha (TGFA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [323]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [323]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [906]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [907]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [908]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [909]
Fructose DM43AN2 Vomiting MD90 Approved [173]
Ketoprofen DMRKXPT Bursitis Approved [173]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [910]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [911]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [912]
Gefitinib DM15F0X Colon adenocarcinoma Approved [407]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [913]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [344]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [914]
Methotrexate DM2TEOL Anterior urethra cancer Approved [428]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [539]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [915]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [916]
Paclitaxel DMLB81S Breast carcinoma Approved [917]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [918]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [919]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [920]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [791]
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Drug(s) Affected By Protein kinase C beta type (PRKCB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [921]
Quercetin DM3NC4M Obesity 5B81 Approved [824]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [782]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [922]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [921]
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Drug(s) Affected By Retinoblastoma-associated protein (RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [923]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [924]
Gefitinib DM15F0X Colon adenocarcinoma Approved [792]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [925]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [310]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [926]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [444]
Methotrexate DM2TEOL Anterior urethra cancer Approved [879]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [927]
Quercetin DM3NC4M Obesity 5B81 Approved [369]
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Drug(s) Affected By DNA excision repair protein ERCC-1 (ERCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [221]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [928]
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [929]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [289]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [930]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [931]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [432]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [932]
Verapamil DMA7PEW Angina pectoris BA40 Approved [933]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [315]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [934]
Selenium DM25CGV N. A. N. A. Approved [935]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [936]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [937]
Methotrexate DM2TEOL Anterior urethra cancer Approved [367]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [506]
Gefitinib DM15F0X Colon adenocarcinoma Approved [938]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [939]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [277]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [940]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [941]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [940]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [410]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [942]
Methotrexate DM2TEOL Anterior urethra cancer Approved [943]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [944]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [945]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [946]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [932]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [359]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [315]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [317]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [318]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [947]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [317]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amphiregulin (AREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [506]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [569]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [433]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [948]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [640]
Estrone DM5T6US Acne vulgaris ED80 Approved [252]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [295]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [949]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [788]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [302]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [521]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [950]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [951]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [952]
Dacarbazine DMNPZL4 Adenocarcinoma 2D40 Approved [953]
Topotecan DMP6G8T Central nervous system neoplasm Approved [954]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein kinase C alpha type (PRKCA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [955]
Quercetin DM3NC4M Obesity 5B81 Approved [956]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [463]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [957]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Capsaicin DMGMF6V Back pain ME84.Z Approved [958]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [931]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [623]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [308]
Gefitinib DM15F0X Colon adenocarcinoma Approved [719]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [310]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [959]
Methotrexate DM2TEOL Anterior urethra cancer Approved [900]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [570]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [253]
Quercetin DM3NC4M Obesity 5B81 Approved [472]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 3-mercaptopyruvate sulfurtransferase (MPST)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [788]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [788]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [149]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [628]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [433]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [277]
Methotrexate DM2TEOL Anterior urethra cancer Approved [960]
Epinephrine DM3KJBC Acute asthma CA23 Approved [961]
Quercetin DM3NC4M Obesity 5B81 Approved [812]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [962]
Fructose DM43AN2 Vomiting MD90 Approved [670]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [628]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [471]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCN family member 2 (CCN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [506]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [323]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [534]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [332]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [254]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [641]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [651]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [153]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [432]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Indomethacin DMSC4A7 Bursitis Approved [900]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [963]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [964]
Methotrexate DM2TEOL Anterior urethra cancer Approved [367]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [965]
Quercetin DM3NC4M Obesity 5B81 Approved [966]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [435]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [436]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [746]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [967]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [968]
Quercetin DM3NC4M Obesity 5B81 Approved [969]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [970]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [971]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [972]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [962]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [255]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [973]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [974]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [148]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [360]
Gefitinib DM15F0X Colon adenocarcinoma Approved [275]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [925]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [433]
Etretinate DM2CZFA Keratosis ED56 Approved [278]
Prednisone DM2HG4X Acute asthma CA23 Approved [975]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [941]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [620]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein kinase C iota type (PRKCI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [270]
Indomethacin DMSC4A7 Bursitis Approved [250]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [270]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [460]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [976]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [647]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [977]
Methotrexate DM2TEOL Anterior urethra cancer Approved [641]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [570]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [978]
Quercetin DM3NC4M Obesity 5B81 Approved [434]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [529]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [641]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [153]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [495]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [979]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [980]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [981]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [916]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [982]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [983]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [984]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [985]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [986]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [987]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [267]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [293]
Prednisone DM2HG4X Acute asthma CA23 Approved [975]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [988]
Quercetin DM3NC4M Obesity 5B81 Approved [472]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [989]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [539]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [990]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [991]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [992]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Radiation-inducible immediate-early gene IEX-1 (IER3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [506]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [310]
Selenium DM25CGV N. A. N. A. Approved [320]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [471]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [153]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [993]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [628]
Selenium DM25CGV N. A. N. A. Approved [149]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [994]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [995]
Methotrexate DM2TEOL Anterior urethra cancer Approved [411]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [435]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [529]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [645]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [996]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [997]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [506]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [998]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [999]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [963]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [277]
Meloxicam DM2AR7L Arthritis FA20 Approved [1000]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [1001]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [1002]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BH3-interacting domain death agonist (BID)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [314]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [277]
Selenium DM25CGV N. A. N. A. Approved [1003]
Quercetin DM3NC4M Obesity 5B81 Approved [472]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [463]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1004]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [1005]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1006]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho-related GTP-binding protein RhoB (RHOB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [347]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [347]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [756]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [234]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [1007]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [1008]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA-dependent protein kinase catalytic subunit (PRKDC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [647]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [293]
Quercetin DM3NC4M Obesity 5B81 Approved [812]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [297]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1009]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [521]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [314]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [1010]
Selenium DM25CGV N. A. N. A. Approved [149]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [366]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [253]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [922]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [1011]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [1012]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein kinase C delta type (PRKCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [297]
Butorphanol DM5KYPJ Pain MG30-MG3Z Approved [1013]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [1014]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [1015]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [1016]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [1017]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA repair protein RAD51 homolog 1 (RAD51)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [267]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [274]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1018]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [1019]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [233]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Quizartinib DM8Y4JS Acute myeloid leukaemia 2A60 Approved [1020]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [919]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1021]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [277]
Selenium DM25CGV N. A. N. A. Approved [149]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [1022]
Methotrexate DM2TEOL Anterior urethra cancer Approved [367]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [536]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [886]
Quercetin DM3NC4M Obesity 5B81 Approved [472]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [435]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine-protein kinase ATM (ATM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [1023]
Paromomycin DM1AGXN Amoebiasis 1A36 Approved [1024]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1025]
Etretinate DM2CZFA Keratosis ED56 Approved [278]
Quercetin DM3NC4M Obesity 5B81 Approved [812]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [1026]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [297]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [746]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [848]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor HES-1 (HES1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1027]
Selenium DM25CGV N. A. N. A. Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [1028]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1029]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [1030]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [314]
Gefitinib DM15F0X Colon adenocarcinoma Approved [1031]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1032]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [277]
Selenium DM25CGV N. A. N. A. Approved [149]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [1001]
Methotrexate DM2TEOL Anterior urethra cancer Approved [428]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [877]
Verapamil DMA7PEW Angina pectoris BA40 Approved [933]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [308]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [318]
Selenium DM25CGV N. A. N. A. Approved [149]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [1033]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [732]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [733]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [1034]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Extracellular tyrosine-protein kinase PKDCC (PKDCC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [859]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [453]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [453]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1035]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pleckstrin homology-like domain family A member 2 (PHLDA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [254]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [302]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [485]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Docking protein 6 (DOK6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [263]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By tRNA-splicing endonuclease subunit Sen2 (TSEN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Flucloxacillin DMNUWST Bacterial infection 1A00-1C4Z Approved [1036]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [209]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [251]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [603]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein FAN (NSMAF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Panobinostat DM58WKG Chronic graft versus host disease Approved [831]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Menthol DMG2KW7 Back pain ME84.Z Approved [256]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [261]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [460]
Topotecan DMP6G8T Central nervous system neoplasm Approved [460]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Probable ATP-dependent RNA helicase DDX17 (DDX17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [293]
Selenium DM25CGV N. A. N. A. Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1037]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [858]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [541]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [541]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Testosterone enanthate DMB6871 N. A. N. A. Approved [132]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By F-box/WD repeat-containing protein 5 (FBXW5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [511]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [243]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [1038]
Drug(s) Affected By PRKC apoptosis WT1 regulator protein (PAWR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [291]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1039]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1040]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Bendamustine hydrochloride DMFH15Z leukaemia 2A60-2B33 Approved [1041]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proheparin-binding EGF-like growth factor (HBEGF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [462]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1042]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [378]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [347]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [347]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [736]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [153]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein HMX1 (HMX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [656]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [607]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [608]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [749]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Abl interactor 2 (ABI2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [380]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [850]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [243]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Inhibitor of Bruton tyrosine kinase (IBTK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [244]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [473]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [553]
Bortezomib DMNO38U Leukemia Approved [339]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [431]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [244]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [244]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By SERTA domain-containing protein 1 (SERTAD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [541]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [541]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [541]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [541]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thrombospondin-1 (THBS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [323]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [534]
Methotrexate DM2TEOL Anterior urethra cancer Approved [428]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [368]
Quercetin DM3NC4M Obesity 5B81 Approved [826]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [347]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [641]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [347]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [486]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phospholipid phosphatase 1 (PLPP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [380]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [332]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [227]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [742]
Methotrexate DM2TEOL Anterior urethra cancer Approved [460]
Paclitaxel DMLB81S Breast carcinoma Approved [19]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA polymerase alpha catalytic subunit (POLA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [267]
Quercetin DM3NC4M Obesity 5B81 Approved [557]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [295]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [505]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [289]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [1043]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [911]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [628]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [1044]
Methotrexate DM2TEOL Anterior urethra cancer Approved [411]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [1045]
Quercetin DM3NC4M Obesity 5B81 Approved [812]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [436]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [628]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [1046]
Ethacrynic acid DM60QMR Edema MG29 Approved [888]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(VII) chain (COL7A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diazepam DM08E9O Alcohol withdrawal Approved [376]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [368]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [380]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [486]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [1047]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [374]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin alpha-E (ITGAE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [417]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [19]
PMID27336223-Compound-5 DM6E50A N. A. N. A. Patented [417]
Glyphosate DM0AFY7 Malaria 1F40-1F45 Investigative [1048]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [663]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nicastrin (NCSTN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [580]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [564]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [227]
Isoflurane DMY6T31 Anaesthesia 9A78.6 Approved [1049]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By V-type proton ATPase 21 kDa proteolipid subunit c'' (ATP6V0B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [557]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [303]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [486]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [1050]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [1051]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1052]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [1053]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [173]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [506]
Verapamil DMA7PEW Angina pectoris BA40 Approved [1054]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [998]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [911]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [1010]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [859]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Methamphetamine DMPM4SK Anxiety Approved [1055]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [1056]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [239]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA polymerase epsilon subunit 2 (POLE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [267]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [433]
Methotrexate DM2TEOL Anterior urethra cancer Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [504]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein DBF4 homolog A (DBF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [267]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [361]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [368]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [554]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glucocorticoid receptor (NR3C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1057]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [323]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Selenium DM25CGV N. A. N. A. Approved [149]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [1058]
Methotrexate DM2TEOL Anterior urethra cancer Approved [428]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [813]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cell division cycle protein 20 homolog (CDC20)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [267]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [274]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [310]
Methotrexate DM2TEOL Anterior urethra cancer Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1059]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RNA-binding motif, single-stranded-interacting protein 1 (RBMS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [293]
Selenium DM25CGV N. A. N. A. Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [557]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [292]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [248]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [227]
Arsenic DMTL2Y1 N. A. N. A. Approved [872]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [599]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By S-phase kinase-associated protein 2 (SKP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [506]
Methotrexate DM2TEOL Anterior urethra cancer Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [1060]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1061]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pre-B-cell leukemia transcription factor-interacting protein 1 (PBXIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [257]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [251]
Urethane DM7NSI0 N. A. N. A. Phase 4 [242]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [149]
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Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [173]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [987]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [314]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [315]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [934]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [1062]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [1063]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1064]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [922]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA mismatch repair protein Mlh1 (MLH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [719]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [1043]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1065]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [236]
Arsenic DMTL2Y1 N. A. N. A. Approved [1066]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [930]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Origin recognition complex subunit 1 (ORC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [506]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [295]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [503]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [392]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By U6 snRNA-associated Sm-like protein LSm7 (LSM7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [1067]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [460]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [149]
PP-242 DM2348V Discovery agent N.A. Investigative [1068]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [548]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [599]
Milchsaure DM462BT Pruritus EC90 Investigative [602]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [380]
Haloperidol DM96SE0 Delirium Approved [373]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [1069]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [1070]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [1070]
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Drug(s) Affected By Transcriptional activator Myb (MYB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [252]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Quercetin DM3NC4M Obesity 5B81 Approved [369]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [1071]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [583]
Estrone DM5T6US Acne vulgaris ED80 Approved [252]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1072]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [1073]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCN family member 1 (CCN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [433]
Methotrexate DM2TEOL Anterior urethra cancer Approved [641]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [368]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [641]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [596]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras-related protein Rab-31 (RAB31)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [541]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [541]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [259]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [541]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Copper-transporting ATPase 1 (ATP7A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [437]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Paclitaxel DMLB81S Breast carcinoma Approved [169]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [1074]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1075]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [1076]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [1076]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1077]
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Drug(s) Affected By Plasma membrane calcium-transporting ATPase 4 (ATP2B4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Methotrexate DM2TEOL Anterior urethra cancer Approved [367]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [371]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [332]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [332]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase CCNB1IP1 (CCNB1IP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [453]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [453]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [431]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [1078]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein FAM50B (FAM50B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Arsenic DMTL2Y1 N. A. N. A. Approved [1079]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [261]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [832]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [263]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By DNA fragmentation factor subunit beta (DFFB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [1080]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [297]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1081]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [153]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family B member 6 (ABCB6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [506]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [1082]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [541]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [541]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [273]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase RNF34 (RNF34)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [244]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [269]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Arsenic DMTL2Y1 N. A. N. A. Approved [266]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [478]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1083]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [1083]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Testosterone DM7HUNW Hot flushes GA30 Approved [224]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [224]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [505]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [641]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [1084]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [506]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [932]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [1085]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [315]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [344]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [319]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [1086]
Methotrexate DM2TEOL Anterior urethra cancer Approved [641]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADPH--cytochrome P450 reductase (POR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [1087]
Selenium DM25CGV N. A. N. A. Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [1088]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [435]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [230]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [486]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [247]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein NDRG1 (NDRG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [344]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [1089]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [366]
Quercetin DM3NC4M Obesity 5B81 Approved [826]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [493]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [465]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [257]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphoserine aminotransferase (PSAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [432]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [218]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [271]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [535]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [432]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [541]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [541]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [211]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Uncharacterized protein C8orf34 (C8ORF34)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [221]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [415]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [287]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [624]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [221]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [221]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [263]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [235]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Small nuclear ribonucleoprotein F (SNRPF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [306]
Testosterone DM7HUNW Hot flushes GA30 Approved [246]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [258]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [561]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [135]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [243]
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Drug(s) Affected By Adenylate kinase 2, mitochondrial (AK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [149]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [299]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [249]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [453]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [453]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [430]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [170]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [241]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA topoisomerase I (TOP1) TTGTQHC TOP1_HUMAN Modulator [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 5 (ABCC5) DTYVM24 MRP5_HUMAN Substrate [4]
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [5]
Multidrug resistance-associated protein 4 (ABCC4) DTCSGPB MRP4_HUMAN Substrate [6]
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [7]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [8]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [9]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [10]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Substrate [11]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Substrate [12]
Carboxylesterase 1 (CES1) Main DME DEB30C5 EST1_HUMAN Substrate [9]
Carboxylesterase 2 (CES2) Main DME DETHCPD EST2_HUMAN Substrate [13]
Carboxylesterase 3 (CES3) Main DME DEMI4VE EST3_HUMAN Substrate [13]
Beta-glucuronidase (uidA) DE9RA0I BGLR_ECOLI Substrate [14]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1) OT9HYT7A PLCB1_HUMAN Drug Response [15]
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (DPH2) OT9P91XR DPH2_HUMAN Gene/Protein Processing [16]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B) OTOA8WU2 PDE4B_HUMAN Gene/Protein Processing [17]
3-mercaptopyruvate sulfurtransferase (MPST) OTCDPH5D THTM_HUMAN Gene/Protein Processing [18]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) OT7TNF0L AAPK1_HUMAN Gene/Protein Processing [16]
5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS2) OTJXOUCL HEM0_HUMAN Gene/Protein Processing [17]
5-formyltetrahydrofolate cyclo-ligase (MTHFS) OTZ39JNR MTHFS_HUMAN Gene/Protein Processing [17]
A-kinase anchor protein 10, mitochondrial (AKAP10) OTPNFTOU AKA10_HUMAN Gene/Protein Processing [17]
Abl interactor 2 (ABI2) OT8GIIS5 ABI2_HUMAN Gene/Protein Processing [18]
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) OTJC60Q7 THIL_HUMAN Drug Response [19]

References

1 Irinotecan FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6823).
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
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752 Role of phenytoin in wound healing: microarray analysis of early transcriptional responses in human dermal fibroblasts. Biochem Biophys Res Commun. 2004 Feb 13;314(3):661-6. doi: 10.1016/j.bbrc.2003.12.146.
753 Fibroblast growth factor-9 is an endometrial stromal growth factor. Endocrinology. 2002 Jul;143(7):2715-21. doi: 10.1210/endo.143.7.8900.
754 Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line. Mol Cancer Ther. 2009 May;8(5):1197-206.
755 DNA double-strand breaks and Aurora B mislocalization induced by exposure of early mitotic cells to H(2)O(2) appear to increase chromatin bridges and resultant cytokinesis failure. Free Radic Biol Med. 2017 Jul;108:129-145. doi: 10.1016/j.freeradbiomed.2017.03.025. Epub 2017 Mar 24.
756 Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. Neurotoxicology. 2015 Sep;50:56-70.
757 Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
758 Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells. Biochemistry. 2007 Aug 7;46(31):8920-32. doi: 10.1021/bi7000328. Epub 2007 Jul 14.
759 Expression Profiling of Human Pluripotent Stem Cell-Derived Cardiomyocytes Exposed to Doxorubicin-Integration and Visualization of Multi-Omics Data. Toxicol Sci. 2018 May 1;163(1):182-195. doi: 10.1093/toxsci/kfy012.
760 Comparative proteomics reveals concordant and discordant biochemical effects of caffeine versus epigallocatechin-3-gallate in human endothelial cells. Toxicol Appl Pharmacol. 2019 Sep 1;378:114621. doi: 10.1016/j.taap.2019.114621. Epub 2019 Jun 10.
761 Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. J Proteome Res. 2009 Jun;8(6):3006-19.
762 Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: role of myeloperoxidase and arylamine free radicals. Chem Biol Interact. 2015 Sep 5;239:129-38.
763 The reduced folate carrier (RFC) is cytotoxic to cells under conditions of severe folate deprivationRFC as a double edged sword in folate homeostasis. J Biol Chem. 2008 Jul 25;283(30):20687-95.
764 The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line. Mol Cancer Ther. 2006 Feb;5(2):438-49. doi: 10.1158/1535-7163.MCT-05-0243.
765 Folic acid uptake by the human syncytiotrophoblast: interference by pharmacotherapy, drugs of abuse and pathological conditions. Reprod Toxicol. 2009 Dec;28(4):511-20. doi: 10.1016/j.reprotox.2009.07.001. Epub 2009 Jul 16.
766 Quantitative proteomics and transcriptomics addressing the estrogen receptor subtype-mediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein. Mol Cell Proteomics. 2011 Jan;10(1):M110.002170.
767 Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer. Cancer Res. 2007 May 15;67(10):5033-41.
768 Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse. Pharmacogenomics J. 2003;3(1):27-40.
769 Chemokine stromal cell-derived factor-1 induction by C/EBPbeta activation is associated with all-trans-retinoic acid-induced leukemic cell differentiation. J Leukoc Biol. 2007 Nov;82(5):1332-9. doi: 10.1189/jlb.1106697. Epub 2007 Jul 26.
770 How benzene and its metabolites affect human marrow derived mesenchymal stem cells. Toxicol Lett. 2012 Oct 17;214(2):145-53. doi: 10.1016/j.toxlet.2012.08.015. Epub 2012 Aug 30.
771 Sevoflurane but not propofol enhances ovarian cancer cell biology through regulating cellular metabolic and signaling mechanisms. Cell Biol Toxicol. 2023 Aug;39(4):1395-1411. doi: 10.1007/s10565-022-09766-6. Epub 2022 Oct 8.
772 Aberrantly expressed genes in HaCaT keratinocytes chronically exposed to arsenic trioxide. Biomark Insights. 2011 Feb 8;6:7-16.
773 Antibody-mediated inhibition of fibroblast growth factor 19 results in increased bile acids synthesis and ileal malabsorption of bile acids in cynomolgus monkeys. Toxicol Sci. 2012 Apr;126(2):446-56. doi: 10.1093/toxsci/kfs011. Epub 2012 Jan 19.
774 Regulation of ileal bile acid-binding protein expression in Caco-2 cells by ursodeoxycholic acid: role of the farnesoid X receptor. Biochem Pharmacol. 2005 Jun 15;69(12):1755-63. doi: 10.1016/j.bcp.2005.03.019.
775 Lithocholic acid decreases expression of UGT2B7 in Caco-2 cells: a potential role for a negative farnesoid X receptor response element. Drug Metab Dispos. 2005 Jul;33(7):937-46.
776 Synergistic effects of arsenic trioxide combined with ascorbic acid in human osteosarcoma MG-63 cells: a systems biology analysis. Eur Rev Med Pharmacol Sci. 2014;18(24):3877-88.
777 Increased matrix proteins, collagen and transforming growth factor are early markers of hepatotoxicity in patients on long-term methotrexate therapy. J Toxicol Clin Toxicol. 1996;34(3):301-5. doi: 10.3109/15563659609013794.
778 Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells. Toxicol Appl Pharmacol. 2009 Feb 1;234(3):345-60.
779 Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals. Int J Mol Sci. 2021 Oct 12;22(20):11005. doi: 10.3390/ijms222011005.
780 Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
781 Phosphorylation of CtBP1 by cAMP-dependent protein kinase modulates induction of CYP17 by stimulating partnering of CtBP1 and 2. J Biol Chem. 2008 Mar 14;283(11):6925-34. doi: 10.1074/jbc.M708432200. Epub 2008 Jan 9.
782 Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
783 A systematic assessment of radiation dose enhancement by 5-Aza-2'-deoxycytidine and histone deacetylase inhibitors in head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2009 Mar 1;73(3):904-12. doi: 10.1016/j.ijrobp.2008.10.032.
784 Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway. Blood. 2011 Jun 2;117(22):5987-97.
785 Expression of connective tissue growth factor, a biomarker in senescence of human diploid fibroblasts, is up-regulated by a transforming growth factor-beta-mediated signaling pathway. Biochem Biophys Res Commun. 2004 Jun 11;318(4):819-25. doi: 10.1016/j.bbrc.2004.04.108.
786 Inhibition of TGF-/SMAD3/NF-B signaling by microRNA-491 is involved in arsenic trioxide-induced anti-angiogenesis in hepatocellular carcinoma cells. Toxicol Lett. 2014 Nov 18;231(1):55-61. doi: 10.1016/j.toxlet.2014.08.024. Epub 2014 Sep 6.
787 Identification and Profiling of Environmental Chemicals That Inhibit the TGF/SMAD Signaling Pathway. Chem Res Toxicol. 2019 Dec 16;32(12):2433-2444. doi: 10.1021/acs.chemrestox.9b00228. Epub 2019 Nov 11.
788 Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006 Jan 10;24(2):274-87. doi: 10.1200/JCO.2005.02.9405. Epub 2005 Dec 19.
789 A genome-wide analysis of targets of macrolide antibiotics in mammalian cells. J Biol Chem. 2020 Feb 14;295(7):2057-2067. doi: 10.1074/jbc.RA119.010770. Epub 2020 Jan 8.
790 In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells. Food Chem Toxicol. 2022 Jan;159:112722. doi: 10.1016/j.fct.2021.112722. Epub 2021 Dec 3.
791 Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
792 Effects and mechanisms of betulinic acid on improving EGFR TKI-resistance of lung cancer cells. Environ Toxicol. 2018 Nov;33(11):1153-1159.
793 Involvement of the p38 MAPK signaling pathway in S-phase cell-cycle arrest induced by Furazolidone in human hepatoma G2 cells. J Appl Toxicol. 2013 Dec;33(12):1500-5. doi: 10.1002/jat.2829. Epub 2012 Oct 30.
794 Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):117-27.
795 Gene expression responses reflecting 5-FU-induced toxicity: Comparison between patient colon tissue and 3D human colon organoids. Toxicol Lett. 2022 Dec 1;371:17-24. doi: 10.1016/j.toxlet.2022.09.013. Epub 2022 Sep 29.
796 Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
797 Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosis. Chem Biol Interact. 2008 Jan 10;171(1):57-66. doi: 10.1016/j.cbi.2007.08.009. Epub 2007 Aug 19.
798 Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-B and matrix metalloproteinase-2/-9 signaling pathways. Anticancer Res. 2013 May;33(5):1941-50.
799 Activation of cannabinoid receptors promote periodontal cell adhesion and migration. J Clin Periodontol. 2019 Dec;46(12):1264-1272. doi: 10.1111/jcpe.13190. Epub 2019 Oct 22.
800 Monomeric and oligomeric flavanols are agonists of membrane androgen receptors. Exp Cell Res. 2005 Oct 1;309(2):329-39. doi: 10.1016/j.yexcr.2005.06.011.
801 Disruption of FAK signaling: a side mechanism in cytotoxicity. Toxicology. 2008 Mar 12;245(1-2):1-10. doi: 10.1016/j.tox.2007.12.003. Epub 2007 Dec 15.
802 Presenilin-2 regulates the degradation of RBP-Jk protein through p38 mitogen-activated protein kinase. J Cell Sci. 2012 Mar 1;125(Pt 5):1296-308. doi: 10.1242/jcs.095984. Epub 2012 Feb 2.
803 Microarray analyses in dendritic cells reveal potential biomarkers for chemical-induced skin sensitization. Mol Immunol. 2007 May;44(12):3222-33.
804 Arsenic trioxide initiates ER stress responses, perturbs calcium signalling and promotes apoptosis in human lens epithelial cells. Exp Eye Res. 2007 Dec;85(6):825-35. doi: 10.1016/j.exer.2007.08.018. Epub 2007 Aug 29.
805 Proteomic analysis of antiproliferative effects by treatment of 5-fluorouracil in cervical cancer cells. DNA Cell Biol. 2004 Nov;23(11):769-76.
806 Soy isoflavones alter expression of genes associated with cancer progression, including interleukin-8, in androgen-independent PC-3 human prostate cancer cells. J Nutr. 2006 Jan;136(1):75-82.
807 Geraniol suppresses prostate cancer growth through down-regulation of E2F8. Cancer Med. 2016 Oct;5(10):2899-2908.
808 Activation of sterile20-like kinase 1 in proteasome inhibitor bortezomib-induced apoptosis in oncogenic K-ras-transformed cells. Cancer Res. 2006 Jun 15;66(12):6072-9. doi: 10.1158/0008-5472.CAN-06-0125.
809 Comparison of quantitation methods in proteomics to define relevant toxicological information on AhR activation of HepG2 cells by BaP. Toxicology. 2021 Jan 30;448:152652. doi: 10.1016/j.tox.2020.152652. Epub 2020 Dec 2.
810 Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein. Autophagy. 2021 Oct;17(10):2783-2799. doi: 10.1080/15548627.2020.1841953. Epub 2020 Nov 9.
811 Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
812 Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
813 Adipocyte differentiation, mitochondrial gene expression and fat distribution: differences between zidovudine and tenofovir after 6 months. Antivir Ther. 2009;14(8):1089-100. doi: 10.3851/IMP1457.
814 Comparative effects of fructose and glucose on lipogenic gene expression and intermediary metabolism in HepG2 liver cells. PLoS One. 2011;6(11):e26583. doi: 10.1371/journal.pone.0026583. Epub 2011 Nov 11.
815 Induction of apoptosis by quercetin is mediated through AMPKalpha1/ASK1/p38 pathway. Cancer Lett. 2010 Jun 28;292(2):228-36. doi: 10.1016/j.canlet.2009.12.005. Epub 2010 Jan 18.
816 Aspirin regulates hepatocellular lipid metabolism by activating AMPK signaling pathway. J Toxicol Sci. 2015 Feb;40(1):127-36. doi: 10.2131/jts.40.127.
817 Testosterone or 17{beta}-estradiol exposure reveals sex-specific effects on glucose and lipid metabolism in human myotubes. J Endocrinol. 2011 Aug;210(2):219-29. doi: 10.1530/JOE-10-0497. Epub 2011 Jun 1.
818 Atorvastatin and pravastatin stimulate nitric oxide and reactive oxygen species generation, affect mitochondrial network architecture and elevate nicotinamide N-methyltransferase level in endothelial cells. J Appl Toxicol. 2021 Jul;41(7):1076-1088. doi: 10.1002/jat.4094. Epub 2020 Oct 19.
819 Activation of autophagy rescues amiodarone-induced apoptosis of lung epithelial cells and pulmonary toxicity in rats. Toxicol Sci. 2013 Nov;136(1):193-204. doi: 10.1093/toxsci/kft168. Epub 2013 Aug 2.
820 Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
821 Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. doi: 10.1158/0008-5472.CAN-07-6381.
822 Mitomycin C induces apoptosis in cultured corneal fibroblasts derived from type II granular corneal dystrophy corneas. Mol Vis. 2008 Jun 30;14:1222-8.
823 Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer. Mol Oncol. 2011 Oct;5(5):438-53. doi: 10.1016/j.molonc.2011.07.003. Epub 2011 Jul 26.
824 Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis. Int J Cancer. 2004 Mar 20;109(2):220-9. doi: 10.1002/ijc.11692.
825 Evaluation of an in vitro model of androgen ablation and identification of the androgen responsive proteome in LNCaP cells. Proteomics. 2007 Jan;7(1):47-63.
826 Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
827 High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2058-63.
828 Glyphosate-based herbicides at low doses affect canonical pathways in estrogen positive and negative breast cancer cell lines. PLoS One. 2019 Jul 11;14(7):e0219610. doi: 10.1371/journal.pone.0219610. eCollection 2019.
829 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
830 Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
831 The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects. Clin Cancer Res. 2016 May 15;22(10):2534-44. doi: 10.1158/1078-0432.CCR-15-1666. Epub 2016 Jan 5.
832 Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma. Int J Cancer. 2015 May 1;136(9):2055-64.
833 Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor alpha signalling and results in tamoxifen insensitive proliferation. BMC Cancer. 2014 Apr 23;14:283.
834 The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines. BMC Med Genomics. 2008 Oct 10;1:49.
835 Bisphenol A and bisphenol S induce distinct transcriptional profiles in differentiating human primary preadipocytes. PLoS One. 2016 Sep 29;11(9):e0163318.
836 New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis. Arch Toxicol. 2016 Jun;90(6):1449-58.
837 Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst Biol. 2012 Dec 10;6:152.
838 Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids. Toxicol Mech Methods. 2023 Jun;33(5):401-410. doi: 10.1080/15376516.2022.2156005. Epub 2022 Dec 19.
839 Research resource: STR DNA profile and gene expression comparisons of human BG-1 cells and a BG-1/MCF-7 clonal variant. Mol Endocrinol. 2014 Dec;28(12):2072-81.
840 Genetic determinants of warfarin maintenance dose and time in therapeutic treatment range: a RE-LY genomics substudy. Pharmacogenomics. 2016 Aug;17(13):1425-39. doi: 10.2217/pgs-2016-0061. Epub 2016 Aug 4.
841 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
842 Transcriptome dynamics of alternative splicing events revealed early phase of apoptosis induced by methylparaben in H1299 human lung carcinoma cells. Arch Toxicol. 2020 Jan;94(1):127-140. doi: 10.1007/s00204-019-02629-w. Epub 2019 Nov 20.
843 Toxicogenomics of kojic acid on gene expression profiling of a375 human malignant melanoma cells. Biol Pharm Bull. 2006 Apr;29(4):655-69.
844 miR-148a/LDLR mediates hypercholesterolemia induced by prenatal dexamethasone exposure in male offspring rats. Toxicol Appl Pharmacol. 2020 May 15;395:114979. doi: 10.1016/j.taap.2020.114979. Epub 2020 Mar 29.
845 A pilot study on the transcriptional response of androgen- and insulin-related genes in peripheral blood mononuclear cells induced by testosterone administration in hypogonadal men. J Biol Regul Homeost Agents. 2011 Apr-Jun;25(2):291-4.
846 Estrogenic endocrine disruptive components interfere with calcium handling and differentiation of human trophoblast cells. J Cell Biochem. 2003 Jul 1;89(4):755-70.
847 Inorganic arsenic exposure promotes malignant progression by HDAC6-mediated down-regulation of HTRA1. J Appl Toxicol. 2023 Aug;43(8):1214-1224. doi: 10.1002/jat.4457. Epub 2023 Mar 11.
848 Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. Med Oncol. 2010 Sep;27(3):833-42. doi: 10.1007/s12032-009-9294-9. Epub 2009 Sep 10.
849 Molecular mechanisms of resveratrol action in lung cancer cells using dual protein and microarray analyses. Cancer Res. 2007 Dec 15;67(24):12007-17. doi: 10.1158/0008-5472.CAN-07-2464.
850 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
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852 Ursodeoxycholic acid-induced inhibition of DLC1 protein degradation leads to suppression of hepatocellular carcinoma cell growth. Oncol Rep. 2011 Jun;25(6):1739-46. doi: 10.3892/or.2011.1239. Epub 2011 Mar 29.
853 Cannabinoid derivatives induce cell death in pancreatic MIA PaCa-2 cells via a receptor-independent mechanism. FEBS Lett. 2006 Mar 20;580(7):1733-9.
854 Effects of progesterone treatment on expression of genes involved in uterine quiescence. Reprod Sci. 2011 Aug;18(8):781-97.
855 1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells. Cell Struct Funct. 2005;30(1):1-6. doi: 10.1247/csf.30.1.
856 Bisphenolic compounds alter gene expression in MCF-7 cells through interaction with estrogen receptor . Toxicol Appl Pharmacol. 2020 Jul 15;399:115030. doi: 10.1016/j.taap.2020.115030. Epub 2020 May 6.
857 Inhibition of 5alpha-reductase enhances testosterone-induced expression of U19/Eaf2 tumor suppressor during the regrowth of LNCaP xenograft tumor in nude mice. Prostate. 2010 Oct 1;70(14):1575-85. doi: 10.1002/pros.21193.
858 Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
859 Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
860 The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
861 RNA sequence analysis of inducible pluripotent stem cell-derived cardiomyocytes reveals altered expression of DNA damage and cell cycle genes in response to doxorubicin. Toxicol Appl Pharmacol. 2018 Oct 1;356:44-53.
862 Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. doi: 10.1002/cam4.1179. Epub 2017 Sep 27.
863 Genome-Wide Analysis of Low Dose Bisphenol-A (BPA) Exposure in Human Prostate Cells. Curr Genomics. 2019 May;20(4):260-274. doi: 10.2174/1389202920666190603123040.
864 m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesis. J Biol Chem. 2022 Feb;298(2):101563. doi: 10.1016/j.jbc.2022.101563. Epub 2022 Jan 6.
865 A genomic approach to predict synergistic combinations for breast cancer treatment. Pharmacogenomics J. 2013 Feb;13(1):94-104. doi: 10.1038/tpj.2011.48. Epub 2011 Nov 15.
866 Differentially expressed genes in the prostate cancer cell line LNCaP after exposure to androgen and anti-androgen. Cancer Genet Cytogenet. 2006 Apr 15;166(2):130-8. doi: 10.1016/j.cancergencyto.2005.09.012.
867 Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study. Toxicol Sci. 2011 Mar;120(1):33-41. doi: 10.1093/toxsci/kfq375. Epub 2010 Dec 22.
868 Transcriptional profiling of MCF7 breast cancer cells in response to 5-Fluorouracil: relationship with cell cycle changes and apoptosis, and identification of novel targets of p53. Int J Cancer. 2006 Sep 1;119(5):1164-75.
869 A high concentration of genistein down-regulates activin A, Smad3 and other TGF-beta pathway genes in human uterine leiomyoma cells. Exp Mol Med. 2012 Apr 30;44(4):281-92.
870 Induction of heme oxygenase-1 by cobalt protoporphyrin enhances the antitumour effect of bortezomib in adult T-cell leukaemia cells. Br J Cancer. 2007 Oct 22;97(8):1099-105. doi: 10.1038/sj.bjc.6604003. Epub 2007 Sep 25.
871 Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. Mol Cancer. 2006 May 18;5:20. doi: 10.1186/1476-4598-5-20.
872 Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environ Health Perspect. 2008 Apr;116(4):524-31. doi: 10.1289/ehp.10861.
873 Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism. Hepatology. 2017 Aug;66(2):432-448. doi: 10.1002/hep.29033. Epub 2017 Jun 16.
874 Analysis of nucleotide insertion opposite 2,2,4-triamino-5(2H)-oxazolone by eukaryotic B- and Y-family DNA polymerases. Chem Res Toxicol. 2015 Jun 15;28(6):1307-16. doi: 10.1021/acs.chemrestox.5b00114. Epub 2015 Jun 3.
875 Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity. Chem Res Toxicol. 2013 Feb 18;26(2):221-32. doi: 10.1021/tx300392m. Epub 2013 Jan 31.
876 Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells. Chem Res Toxicol. 2016 Jan 19;29(1):101-8. doi: 10.1021/acs.chemrestox.5b00452. Epub 2015 Dec 30.
877 Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
878 Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nat Commun. 2018 Aug 9;9(1):3069. doi: 10.1038/s41467-018-05402-2.
879 Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance. Exp Cell Res. 2012 Jun 10;318(10):1146-59.
880 Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin. Toxicol Mech Methods. 2017 Mar;27(3):165-172. doi: 10.1080/15376516.2016.1273424. Epub 2017 Jan 8.
881 Long-term exposure to zidovudine delays cell cycle progression, induces apoptosis, and decreases telomerase activity in human hepatocytes. Toxicol Sci. 2009 Sep;111(1):120-30. doi: 10.1093/toxsci/kfp136. Epub 2009 Jun 18.
882 ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis. J Biol Chem. 2006 Sep 29;281(39):28764-71. doi: 10.1074/jbc.M604392200. Epub 2006 Aug 3.
883 Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J Biol Chem. 2012 Apr 20;287(17):14289-300. doi: 10.1074/jbc.M112.353201. Epub 2012 Mar 1.
884 PGK1 induction by a hydrogen peroxide treatment is suppressed by antioxidants in human colon carcinoma cells. Biosci Biotechnol Biochem. 2008 Jul;72(7):1799-808. doi: 10.1271/bbb.80079. Epub 2008 Jul 7.
885 Combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and actinomycin D induces apoptosis even in TRAIL-resistant human pancreatic cancer cells. Clin Cancer Res. 2001 Feb;7(2):407-14.
886 Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. Int J Cancer. 2008 Aug 15;123(4):951-7. doi: 10.1002/ijc.23593.
887 Rifampicin inhibits CD95-mediated apoptosis of Jurkat T cells via glucocorticoid receptors by modifying the expression of molecules regulating apoptosis. J Clin Immunol. 2002 Jan;22(1):37-47. doi: 10.1023/a:1014256603539.
888 Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase p1-1. Clin Cancer Res. 2012 Dec 15;18(24):6690-701. doi: 10.1158/1078-0432.CCR-12-0770. Epub 2012 Oct 18.
889 Effect of mitochondrial dysfunction and oxidative stress on endogenous levels of coenzyme Q(10) in human cells. J Biochem Mol Toxicol. 2011 Sep-Oct;25(5):280-9. doi: 10.1002/jbt.20387. Epub 2011 Feb 9.
890 The effects of bisphenol A and bisphenol S on adipokine expression and glucose metabolism in human adipose tissue. Toxicology. 2020 Dec 1;445:152600. doi: 10.1016/j.tox.2020.152600. Epub 2020 Sep 22.
891 Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
892 Cigarette smoke extract interferes with placenta macrophage functions: A new mechanism to compromise placenta functions?. Reprod Toxicol. 2018 Jun;78:120-129. doi: 10.1016/j.reprotox.2018.04.009. Epub 2018 Apr 16.
893 Triclosan Induces Thymic Stromal Lymphopoietin in Skin Promoting Th2 Allergic Responses. Toxicol Sci. 2015 Sep;147(1):127-39. doi: 10.1093/toxsci/kfv113. Epub 2015 Jun 5.
894 Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil. PLoS One. 2011;6(12):e28862. doi: 10.1371/journal.pone.0028862. Epub 2011 Dec 15.
895 Direct activation of ATM by resveratrol under oxidizing conditions. PLoS One. 2014 Jun 16;9(6):e97969. doi: 10.1371/journal.pone.0097969. eCollection 2014.
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897 Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity. Anat Cell Biol. 2016 Sep;49(3):165-176. doi: 10.5115/acb.2016.49.3.165. Epub 2016 Sep 29.
898 Inactivation of cytochrome c oxidase by mutant SOD1s in mouse motoneuronal NSC-34 cells is independent from copper availability but is because of nitric oxide. J Neurochem. 2010 Jan;112(1):183-92. doi: 10.1111/j.1471-4159.2009.06441.x. Epub 2009 Oct 20.
899 Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen. Brain. 2006 Jul;129(Pt 7):1693-709. doi: 10.1093/brain/awl118. Epub 2006 May 15.
900 Development of an alternative zebrafish model for drug-induced intestinal toxicity. J Appl Toxicol. 2018 Feb;38(2):259-273. doi: 10.1002/jat.3520. Epub 2017 Oct 13.
901 Epinephrine upregulates superoxide dismutase in human coronary artery endothelial cells. Free Radic Biol Med. 2001 Jan 15;30(2):148-53.
902 Molecular pathways in the chemosensitization of cisplatin by quercetin in human head and neck cancer. Cancer Biol Ther. 2005 Sep;4(9):949-55.
903 Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3). Cell Biochem Funct. 2011 Mar;29(2):87-95. doi: 10.1002/cbf.1725. Epub 2011 Feb 9.
904 Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: role of nuclear factor-kappaB and reactive oxygen species. J Cell Biochem. 2005 Aug 1;95(5):955-69. doi: 10.1002/jcb.20452.
905 Atorvastatin affects several angiogenic mediators in human endothelial cells. Endothelium. 2005 Sep-Dec;12(5-6):233-41.
906 Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
907 The psychoactive substance of cannabis 9-tetrahydrocannabinol (THC) negatively regulates CFTR in airway cells. Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):1988-1994. doi: 10.1016/j.bbagen.2018.06.008. Epub 2018 Jun 19.
908 Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells. J Biochem Mol Toxicol. 2020 Feb;34(2):e22433. doi: 10.1002/jbt.22433. Epub 2020 Jan 9.
909 A cell impedance-based real-time in vitro assay to assess the toxicity of amphotericin B formulations. Toxicol Appl Pharmacol. 2017 Nov 1;334:18-23. doi: 10.1016/j.taap.2017.08.017. Epub 2017 Sep 1.
910 CBD Promotes Oral Ulcer Healing via Inhibiting CMPK2-Mediated Inflammasome. J Dent Res. 2022 Feb;101(2):206-215. doi: 10.1177/00220345211024528. Epub 2021 Jul 16.
911 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
912 Anti-inflammatory effects of the GABA(B) receptor agonist baclofen in allergic contact dermatitis. Exp Dermatol. 2010 Jul 1;19(7):661-6. doi: 10.1111/j.1600-0625.2010.01076.x. Epub 2010 Feb 25.
913 Sulfasalazine unveils a contact-independent HSV-TK/ganciclovir gene therapy bystander effect in malignant gliomas. Int J Oncol. 2007 Jan;30(1):283-90.
914 p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
915 Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
916 Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
917 Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
918 Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. Nucleic Acids Res. 2009 Jan;37(1):78-95. doi: 10.1093/nar/gkn910. Epub 2008 Nov 16.
919 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
920 Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
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922 Prevention of deoxycholate-induced gastric apoptosis by aspirin: roles of NF-kappaB and PKC signaling. J Surg Res. 2008 Mar;145(1):66-73. doi: 10.1016/j.jss.2007.04.039. Epub 2007 Jul 20.
923 Indomethacin inhibits cell growth of medullary thyroid carcinoma by reducing cell cycle progression into S phase. Exp Biol Med (Maywood). 2008 Nov;233(11):1433-40. doi: 10.3181/0804-RM-127. Epub 2008 Sep 12.
924 Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer. Endocr Relat Cancer. 2011 Apr 28;18(3):333-45. doi: 10.1530/ERC-10-0262. Print 2011 Jun.
925 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
926 Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
927 HMG-CoA reductase inhibitor simvastatin inhibits cell cycle progression at the G1/S checkpoint in immortalized lymphocytes from Alzheimer's disease patients independently of cholesterol-lowering effects. J Pharmacol Exp Ther. 2008 Jan;324(1):352-9. doi: 10.1124/jpet.107.128959. Epub 2007 Oct 10.
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930 DNA demethylation by 5-aza-2-deoxycytidine treatment abrogates 17 beta-estradiol-induced cell growth and restores expression of DNA repair genes in human breast cancer cells. Cancer Lett. 2012 Mar;316(1):62-9. doi: 10.1016/j.canlet.2011.10.022. Epub 2011 Oct 23.
931 Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
932 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
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936 Dimethyl Fumarate Inhibits the Nuclear Factor B Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. J Biol Chem. 2016 Feb 12;291(7):3639-47. doi: 10.1074/jbc.M115.679704. Epub 2015 Dec 18.
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958 The vanilloid capsaicin induces IL-6 secretion in prostate PC-3 cancer cells. Cytokine. 2011 Jun;54(3):330-7. doi: 10.1016/j.cyto.2011.03.010. Epub 2011 Apr 6.
959 The thioredoxin system mediates redox-induced cell death in human colon cancer cells: implications for the mechanism of action of anticancer agents. Cancer Res. 2008 Oct 15;68(20):8269-77. doi: 10.1158/0008-5472.CAN-08-2010.
960 Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells. Biol Chem. 2006 Dec;387(12):1629-33. doi: 10.1515/BC.2006.203.
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967 COX-2 and PPAR-gama confer cannabidiol-induced apoptosis of human lung cancer cells. Mol Cancer Ther. 2013 Jan;12(1):69-82.
968 Protective effects of myricitrin against osteoporosis via reducing reactive oxygen species and bone-resorbing cytokines. Toxicol Appl Pharmacol. 2014 Nov 1;280(3):550-60.
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973 Mitochondrial proliferation, DNA depletion and adipocyte differentiation in subcutaneous adipose tissue of HIV-positive HAART recipients. Antivir Ther. 2003 Aug;8(4):323-31.
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987 Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
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993 Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 2011 Mar;13(3):267-79. doi: 10.1093/neuonc/noq195. Epub 2011 Feb 3.
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1015 Aspirin induces apoptosis through release of cytochrome c from mitochondria. Neoplasia. 2000 Nov-Dec;2(6):505-13. doi: 10.1038/sj.neo.7900120.
1016 Early Transcriptomic Changes upon Thalidomide Exposure Influence the Later Neuronal Development in Human Embryonic Stem Cell-Derived Spheres. Int J Mol Sci. 2020 Aug 3;21(15):5564. doi: 10.3390/ijms21155564.
1017 Lipid raft-dependent death receptor 5 (DR5) expression and activation are critical for ursodeoxycholic acid-induced apoptosis in gastric cancer cells. Carcinogenesis. 2011 May;32(5):723-31. doi: 10.1093/carcin/bgr038. Epub 2011 Feb 28.
1018 Propolis alleviates 4-aminobiphenyl-induced oxidative DNA damage by inhibition of CYP2E1 expression in human liver cells. Environ Toxicol. 2021 Aug;36(8):1504-1513. doi: 10.1002/tox.23147. Epub 2021 Apr 13.
1019 Unpredicted Downregulation of RAD51 Suggests Genome Instability Induced by Tetrachlorobenzoquinone. Chem Res Toxicol. 2016 Dec 19;29(12):2184-2193. doi: 10.1021/acs.chemrestox.6b00369. Epub 2016 Nov 21.
1020 Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3. Arch Toxicol. 2022 Jan;96(1):177-193. doi: 10.1007/s00204-021-03174-1. Epub 2021 Oct 19.
1021 Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death. Mol Pharmacol. 2005 May;67(5):1808-17. doi: 10.1124/mol.104.005769. Epub 2005 Feb 9.
1022 Role of BAX in the apoptotic response to anticancer agents. Science. 2000 Nov 3;290(5493):989-92. doi: 10.1126/science.290.5493.989.
1023 Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells. Biomolecules. 2019 Jul 25;9(8):302. doi: 10.3390/biom9080302.
1024 Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons. Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15676-81. doi: 10.1073/pnas.0405155101. Epub 2004 Oct 21.
1025 Pro-oxidant induced DNA damage in human lymphoblastoid cells: homeostatic mechanisms of genotoxic tolerance. Toxicol Sci. 2012 Aug;128(2):387-97. doi: 10.1093/toxsci/kfs152. Epub 2012 Apr 26.
1026 An in vitro study on anti-carcinogenic effect of remdesivir in human ovarian cancer cells via generation of reactive oxygen species. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089257. doi: 10.1177/09603271221089257.
1027 Modulation of notch signaling pathway to prevent H2O2/menadione-induced SK-N-MC cells death by EUK134. Cell Mol Neurobiol. 2014 Oct;34(7):1037-45. doi: 10.1007/s10571-014-0079-0. Epub 2014 Jul 9.
1028 Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells. Carcinogenesis. 2005 May;26(5):883-91. doi: 10.1093/carcin/bgi036. Epub 2005 Feb 10.
1029 Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis. Br J Cancer. 2011 Apr 12;104(8):1278-87. doi: 10.1038/bjc.2011.84.
1030 Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells. Mol Cancer. 2011 Jul 31;10:95. doi: 10.1186/1476-4598-10-95.
1031 The anti-cancer drug gefitinib accelerates Fas-mediated apoptosis by enhancing caspase-8 activation in cancer cells. J Toxicol Sci. 2019;44(6):435-440. doi: 10.2131/jts.44.435.
1032 Melatonin enhances hydrogen peroxide-induced apoptosis in human promyelocytic leukaemia HL-60 cells. Mol Cell Biochem. 2011 Jul;353(1-2):167-76. doi: 10.1007/s11010-011-0783-8. Epub 2011 Mar 23.
1033 Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease. J Neurosci. 2016 Jun 8;36(23):6332-51. doi: 10.1523/JNEUROSCI.0426-16.2016.
1034 P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation. Food Chem Toxicol. 2016 Feb;88:1-12. doi: 10.1016/j.fct.2015.12.004. Epub 2015 Dec 11.
1035 Comparative Analysis of Transcriptomic Changes including mRNA and microRNA Expression Induced by the Xenoestrogens Zearalenone and Bisphenol A in Human Ovarian Cells. Toxins (Basel). 2023 Feb 9;15(2):140. doi: 10.3390/toxins15020140.
1036 Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury. Toxicol Sci. 2023 Mar 20;192(1):106-116. doi: 10.1093/toxsci/kfad015.
1037 Developmental and tissue-specific expression of DEAD box protein p72. Neuroreport. 2000 Feb 28;11(3):457-62. doi: 10.1097/00001756-200002280-00006.
1038 Identification of formaldehyde-responsive genes by suppression subtractive hybridization. Toxicology. 2008 Jan 14;243(1-2):224-35.
1039 Par-4 transcriptionally regulates Bcl-2 through a WT1-binding site on the bcl-2 promoter. J Biol Chem. 2003 May 30;278(22):19995-20005. doi: 10.1074/jbc.M205865200. Epub 2003 Mar 17.
1040 Down-regulation of wt1 expression in leukemia cell lines as part of apoptotic effect in arsenic treatment using two compounds. Leuk Lymphoma. 2006 Aug;47(8):1629-38. doi: 10.1080/10428190600625398.
1041 Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation. Biochem Pharmacol. 2003 Sep 1;66(5):711-24. doi: 10.1016/s0006-2952(03)00410-6.
1042 Vanadium-induced HB-EGF expression in human lung fibroblasts is oxidant dependent and requires MAP kinases. Am J Physiol Lung Cell Mol Physiol. 2003 May;284(5):L774-82. doi: 10.1152/ajplung.00189.2002. Epub 2003 Jan 10.
1043 Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray. Cancer Lett. 2005 Apr 8;220(2):197-210.
1044 The role of MITF and Mcl-1 proteins in the antiproliferative and proapoptotic effect of ciprofloxacin in amelanotic melanoma cells: In silico and in vitro study. Toxicol In Vitro. 2020 Aug;66:104884. doi: 10.1016/j.tiv.2020.104884. Epub 2020 May 8.
1045 Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation. Br J Cancer. 2011 Jul 12;105(2):221-30. doi: 10.1038/bjc.2011.229.
1046 Anti-cancer properties of glucosamine-hydrochloride in YD-8 human oral cancer cells: Induction of the caspase-dependent apoptosis and down-regulation of HIF-1. Toxicol In Vitro. 2012 Feb;26(1):42-50. doi: 10.1016/j.tiv.2011.10.005. Epub 2011 Oct 13.
1047 Ultradian cortisol pulsatility encodes a distinct, biologically important signal. PLoS One. 2011 Jan 18;6(1):e15766.
1048 Alteration of estrogen-regulated gene expression in human cells induced by the agricultural and horticultural herbicide glyphosate. Hum Exp Toxicol. 2007 Sep;26(9):747-52. doi: 10.1177/0960327107083453.
1049 The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation. J Neurosci. 2007 Feb 7;27(6):1247-54. doi: 10.1523/JNEUROSCI.5320-06.2007.
1050 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
1051 Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
1052 Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
1053 Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
1054 Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
1055 Inhibition of PLC1 signaling pathway regulates methamphetamine self-administration and neurotoxicity in rats. Food Chem Toxicol. 2021 Mar;149:111970. doi: 10.1016/j.fct.2021.111970. Epub 2021 Jan 7.
1056 Reduction of phosphoinositide-phospholipase C beta1 methylation predicts the responsiveness to azacitidine in high-risk MDS. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16811-6. doi: 10.1073/pnas.0907109106. Epub 2009 Sep 10.
1057 Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2011 Feb;123(3-5):140-50.
1058 Comparative effects of microtubules disruption on glucocorticoid receptor functions in proliferating and quiescent cells. Int J Toxicol. 2010 May-Jun;29(3):326-35. doi: 10.1177/1091581810366486.
1059 [Effects of Arsenic Trioxide on Cdc20 and Mad2 in Acute Myeloid Leukemia HL-60 Cell Line]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018 Jun;26(3):710-715. doi: 10.7534/j.issn.1009-2137.2018.03.013.
1060 Troglitazone induces p27Kip1-associated cell-cycle arrest through down-regulating Skp2 in human hepatoma cells. Hepatology. 2003 May;37(5):1086-96. doi: 10.1053/jhep.2003.50186.
1061 E2F1 downregulation by arsenic trioxide in lung adenocarcinoma. Int J Oncol. 2014 Nov;45(5):2033-43. doi: 10.3892/ijo.2014.2609. Epub 2014 Aug 19.
1062 Microtubules are required for NF-kappaB nuclear translocation in neuroblastoma IMR-32 cells: modulation by zinc. J Neurochem. 2006 Oct;99(2):402-15. doi: 10.1111/j.1471-4159.2006.04005.x.
1063 Protein phosphatase 2A interacts with and directly dephosphorylates RelA. J Biol Chem. 2001 Dec 21;276(51):47828-33. doi: 10.1074/jbc.M106103200. Epub 2001 Oct 8.
1064 Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells. Mol Pharmacol. 2008 Aug;74(2):476-84.
1065 Expression and promoter methylation status of mismatch repair gene hMLH1 and hMSH2 in epithelial ovarian cancer. Aust N Z J Obstet Gynaecol. 2008 Oct;48(5):505-9. doi: 10.1111/j.1479-828X.2008.00892.x.
1066 Epigenetic alteration of mismatch repair genes in the population chronically exposed to arsenic in West Bengal, India. Environ Res. 2018 May;163:289-296. doi: 10.1016/j.envres.2018.01.002. Epub 2018 Feb 27.
1067 Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway. Blood. 2005 Feb 1;105(3):1214-21. doi: 10.1182/blood-2004-03-1182. Epub 2004 Sep 28.
1068 Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway. Sci Rep. 2019 Jan 24;9(1):675.
1069 Linalool is a PPARalpha ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome. J Lipid Res. 2014 Jun;55(6):1098-110.
1070 Comparison of the effects of pioglitazone and rosiglitazone on macrophage foam cell formation. Biochem Biophys Res Commun. 2004 Oct 22;323(3):782-8.
1071 Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells. J Pharmacol Exp Ther. 2003 Jun;305(3):932-42. doi: 10.1124/jpet.103.049098. Epub 2003 Mar 20.
1072 Hypomethylation mediated by decreased DNMTs involves in the activation of proto-oncogene MPL in TK6 cells treated with hydroquinone. Toxicol Lett. 2012 Mar 25;209(3):239-45. doi: 10.1016/j.toxlet.2011.12.020. Epub 2012 Jan 8.
1073 Thalidomide alters c-MYB and PIM-1 signaling in K-562 cells. Pharmacol Res. 2006 Aug;54(2):91-6. doi: 10.1016/j.phrs.2006.02.010. Epub 2006 Mar 8.
1074 Effects of different sources of copper on Ctr1, ATP7A, ATP7B, MT and DMT1 protein and gene expression in Caco-2 cells. J Trace Elem Med Biol. 2014 Jul;28(3):344-50.
1075 Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells. Biochem J. 2007 Mar 1;402(2):241-50. doi: 10.1042/BJ20061099.
1076 Copper-transporting P-type ATPase, ATP7A, confers multidrug resistance and its expression is related to resistance to SN-38 in clinical colon cancer. Cancer Res. 2007 May 15;67(10):4860-8. doi: 10.1158/0008-5472.CAN-06-3096.
1077 Copper-transporting P-type adenosine triphosphatase (ATP7A) is associated with platinum-resistance in non-small cell lung cancer (NSCLC). J Transl Med. 2012 Feb 3;10:21. doi: 10.1186/1479-5876-10-21.
1078 Microarray analysis of bicalutamide action on telomerase activity, p53 pathway and viability of prostate carcinoma cell lines. J Pharm Pharmacol. 2005 Jan;57(1):83-92.
1079 Transcriptomics and methylomics of CD4-positive T cells in arsenic-exposed women. Arch Toxicol. 2017 May;91(5):2067-2078. doi: 10.1007/s00204-016-1879-4. Epub 2016 Nov 12.
1080 Sulindac activates nuclear translocation of AIF, DFF40 and endonuclease G but not induces oligonucleosomal DNA fragmentation in HT-29 cells. Life Sci. 2005 Sep 2;77(16):2059-70. doi: 10.1016/j.lfs.2005.04.021.
1081 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
1082 Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
1083 Exogenous expression of hRFI induces multidrug resistance through escape from apoptosis in colorectal cancer cells. Anticancer Res. 2005 Jul-Aug;25(4):2737-41.
1084 Mechanisms of dexamethasone-induced disturbed sleep and fatigue in paediatric patients receiving treatment for ALL. Eur J Cancer. 2010 Jul;46(10):1848-55. doi: 10.1016/j.ejca.2010.03.026. Epub 2010 Apr 17.
1085 Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
1086 Blood cell oxidative stress precedes hemolysis in whole blood-liver slice co-cultures of rat, dog, and human tissues. Toxicol Appl Pharmacol. 2010 May 1;244(3):354-65. doi: 10.1016/j.taap.2010.01.017. Epub 2010 Feb 6.
1087 Single-nucleotide polymorphisms in P450 oxidoreductase and peroxisome proliferator-activated receptor- are associated with the development of new-onset diabetes after transplantation in kidney transplant recipients treated with tacrolimus. Pharmacogenet Genomics. 2013 Dec;23(12):649-57. doi: 10.1097/FPC.0000000000000001.
1088 StJohn's wort extracts and some of their constituents potently inhibit ultimate carcinogen formation from benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1. Cancer Res. 2003 Nov 15;63(22):8062-8.
1089 Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1) expression: role of chelatable iron. J Biol Chem. 2011 Dec 2;286(48):41413-41424. doi: 10.1074/jbc.M111.287052. Epub 2011 Oct 5.