Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMI12Y8)

• Drug Name: Nickel chloride Drug Info
• Synonyms: NICKEL CHLORIDE; Nickel(II) chloride; 7718-54-9; Nickel dichloride; Nickelous chloride; NiCl2; Nickel(2+) chloride; Nickel chloride (NiCl2); dichloronickel; Nickelchloride; Nickel dichloride (nicl2); Nickel(II) chloride (1:2); Nichel(II) chloride; Nickel (II) chloride; Nickel(II) chloride, 98%; Nickel(II) chloride anhydrous; CCRIS 1788; HSDB 860; EINECS 231-743-0; EINECS 253-399-0; NSC 254532; Nickel chloride [Nickel and nickel compounds]; 37211-05-5; dichloro nickel; Nickel(II) chloride, 99.99%, (trace metal basis), anhydrous, po

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 24385
  ChEBI ID: CHEBI:34887
  CAS Number: CAS 37211-0
  TTD Drug ID: DMI12Y8

Molecule-Related Drug Atlas

Drug(s) Targeting Voltage-gated calcium channel alpha Cav3.1 (CACNA1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[9]
Ethosuximide	DMDZ9LT	Epilepsy	8A60-8A68	Approved	[10]
Trimethadione	DM0Q8MZ	Absence epilepsy		Approved	[11]
Paramethadione	DMR5ZUP	Absence epilepsy		Approved	[11]
Methsuximide	DM6L5VO	Absence epilepsy		Approved	[12]
Penfluridol	DMG1DTE	Schizophrenia	6A20	Approved	[13]
PD-200390	DMPW28M	Insomnia	7A00-7A0Z	Phase 2	[14]
NGD 94-1	DMM1Y8F	Schizophrenia	6A20	Phase 1	[13]
ML218	DM3D21X	Discovery agent	N.A.	Investigative	[15]
KYS-05001	DM3MID9	Discovery agent	N.A.	Investigative	[16]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[17]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[18]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[19]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[21]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[22]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[23]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[24]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[25]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 12 (PSMD12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[29]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Bortezomib	DMNO38U	Leukemia		Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[36]

Drug(s) Affected By Phospholipid phosphatase 3 (PLPP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[39]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]

Drug(s) Affected By Fucose-1-phosphate guanylyltransferase (FPGT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[47]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[49]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[50]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[51]

Drug(s) Affected By Transcription regulator protein BACH1 (BACH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]

Drug(s) Affected By PDZ domain-containing protein 2 (PDZD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[63]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[67]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[68]

Drug(s) Affected By Phosphoribosylformylglycinamidine synthase (PFAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[36]

Drug(s) Affected By Sphingolipid delta(4)-desaturase DES1 (DEGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[75]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[78]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[49]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]

Drug(s) Affected By mRNA cap guanine-N7 methyltransferase (RNMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[80]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[82]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[83]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]

Drug(s) Affected By Leucine-rich repeat transmembrane protein FLRT2 (FLRT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[86]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[87]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[89]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[90]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[91]

Drug(s) Affected By RNA binding protein fox-1 homolog 2 (RBFOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[47]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[92]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[94]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[95]

Drug(s) Affected By Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[97]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[98]

Drug(s) Affected By Forkhead box protein O3 (FOXO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[99]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[103]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]

Drug(s) Affected By Protein O-GlcNAcase (OGA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[107]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[109]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[49]

Drug(s) Affected By Ran-binding protein 6 (RANBP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[110]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[49]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[111]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[112]

Drug(s) Affected By DnaJ homolog subfamily B member 6 (DNAJB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[113]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[115]

Drug(s) Affected By Lathosterol oxidase (SC5D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[116]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[118]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Haloperidol	DM96SE0	Delirium		Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By Triple functional domain protein (TRIO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Bortezomib	DMNO38U	Leukemia		Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]

Drug(s) Affected By Stanniocalcin-2 (STC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[125]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[127]

Drug(s) Affected By Lysine-specific demethylase 4B (KDM4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Bortezomib	DMNO38U	Leukemia		Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[131]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 8 (TNFAIP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[134]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[135]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[116]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[137]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]

Drug(s) Affected By Chromobox protein homolog 6 (CBX6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[144]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[49]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[145]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[38]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[94]

Drug(s) Affected By G1/S-specific cyclin-E2 (CCNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[147]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[148]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[151]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[125]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[134]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[152]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[153]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[157]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[154]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[158]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[159]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[116]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[161]

Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[163]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[164]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[165]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[166]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[167]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[168]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[169]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[170]

Drug(s) Affected By Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[171]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[172]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[173]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Selenium	DM25CGV	N. A.	N. A.	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[176]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[179]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[180]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[181]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[181]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[159]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[182]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[183]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[184]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[185]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[186]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[187]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[188]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[189]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[188]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[190]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[188]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]

Drug(s) Affected By Inhibin beta A chain (INHBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[86]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[194]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[195]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[196]

Drug(s) Affected By Gamma-enolase (ENO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[197]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[198]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[199]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[200]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[134]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Selenium	DM25CGV	N. A.	N. A.	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[179]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[201]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[39]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[201]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[202]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[203]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[204]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[205]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Selenium	DM25CGV	N. A.	N. A.	Approved	[207]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[187]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[208]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]

Drug(s) Affected By Macrophage colony-stimulating factor 1 (CSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[210]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[212]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[213]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[214]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]

Drug(s) Affected By Granulocyte colony-stimulating factor (CSF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[215]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[216]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[166]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[214]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[217]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[39]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[218]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[219]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[220]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[221]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[222]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[164]

Drug(s) Affected By RNA-binding protein RO60 (RO60)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[134]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[134]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[134]

Drug(s) Affected By Heat shock cognate 71 kDa protein (HSPA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[223]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[220]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[189]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[224]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[225]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[226]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[227]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[228]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[229]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[52]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[188]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[230]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[188]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]

Drug(s) Affected By Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[232]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[233]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[234]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[235]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[24]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[236]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[237]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[238]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[239]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[187]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[240]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]

Drug(s) Affected By Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[242]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Interferon regulatory factor 2 (IRF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[246]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[83]

Drug(s) Affected By Interferon gamma receptor 1 (IFNGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[249]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[250]

Drug(s) Affected By Fos-related antigen 2 (FOSL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[251]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[134]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]

Drug(s) Affected By Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[155]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[31]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[253]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[254]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[255]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[256]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[257]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[258]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[259]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[260]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[261]

Drug(s) Affected By E-selectin (SELE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[262]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[263]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[265]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[267]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[268]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[269]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[270]

Drug(s) Affected By Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[126]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[271]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[76]

Drug(s) Affected By Protein kinase C alpha type (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[272]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[273]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[274]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[275]

Drug(s) Affected By Transcription factor JunB (JUNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[276]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[277]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[278]

Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[279]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[280]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[281]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[242]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[283]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[284]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[203]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[285]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[220]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[286]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[288]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[289]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[279]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[290]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[291]

Drug(s) Affected By C-X-C motif chemokine 2 (CXCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Selenium	DM25CGV	N. A.	N. A.	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]

Drug(s) Affected By C-X-C motif chemokine 3 (CXCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[206]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[294]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[194]

Drug(s) Affected By Ephrin-A1 (EFNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[296]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[297]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[298]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[297]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[299]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[300]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[297]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase beta (PTPRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[301]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[302]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[303]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[68]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[44]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[304]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[305]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[306]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[307]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[308]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[309]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[310]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[311]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[312]

Drug(s) Affected By Atypical chemokine receptor 3 (ACKR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[39]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]

Drug(s) Affected By Integrin beta-8 (ITGB8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[313]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[314]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[315]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[316]

Drug(s) Affected By Protein-lysine 6-oxidase (LOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[317]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[318]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]

Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Selenium	DM25CGV	N. A.	N. A.	Approved	[319]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[149]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[320]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[321]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[151]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[322]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By S-adenosylmethionine synthase isoform type-2 (MAT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[323]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[324]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[325]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[324]

Drug(s) Affected By Syndecan-4 (SDC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[326]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[327]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[29]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[328]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[329]

Drug(s) Affected By Cytotoxic granule associated RNA binding protein TIA1 (TIA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[330]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[246]

Drug(s) Affected By Transcription factor HIVEP2 (HIVEP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[331]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[194]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[332]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]

Drug(s) Affected By Guanylate-binding protein 1 (GBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[333]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[39]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]

Drug(s) Affected By DNA replication licensing factor MCM4 (MCM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[283]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[291]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[334]

Drug(s) Affected By Serine hydroxymethyltransferase, mitochondrial (SHMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[251]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[194]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[335]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]

Drug(s) Affected By Pro-adrenomedullin (ADM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[336]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[326]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[337]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[203]

Drug(s) Affected By Nuclear receptor ROR-alpha (RORA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[338]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[318]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[339]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[155]

Drug(s) Affected By Transcription factor SOX-18 (SOX18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]
Indomethacin	DMSC4A7	Bursitis		Approved	[340]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[341]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[31]

Drug(s) Affected By Interferon gamma receptor 2 (IFNGR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[342]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[343]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[87]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By Replication factor C subunit 3 (RFC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[344]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 8 (MAP3K8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]

Drug(s) Affected By Lamina-associated polypeptide 2, isoform alpha (TMPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[189]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[94]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]

Drug(s) Affected By C-X-C motif chemokine 5 (CXCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[345]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[86]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[346]

Drug(s) Affected By ATP-binding cassette sub-family G member 1 (ABCG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[136]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[347]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[134]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[134]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[242]

Drug(s) Affected By Eukaryotic translation initiation factor 1A, X-chromosomal (EIF1AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[251]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[115]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Indomethacin	DMSC4A7	Bursitis		Approved	[340]

Drug(s) Affected By Casein kinase I isoform delta (CSNK1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[49]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[348]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[160]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[349]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[350]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[351]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[352]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[201]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[353]

Drug(s) Affected By Cysteine--tRNA ligase, cytoplasmic (CARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[242]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[354]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[134]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]

Drug(s) Affected By Protein phosphatase 1F (PPM1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[323]
Bortezomib	DMNO38U	Leukemia		Approved	[34]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[313]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[94]

Drug(s) Affected By CCAAT/enhancer-binding protein delta (CEBPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]

Drug(s) Affected By DNA replication licensing factor MCM2 (MCM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[291]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[355]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[356]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Dual specificity protein kinase CLK1 (CLK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[210]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[126]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[357]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]

Drug(s) Affected By Sulfate transporter (SLC26A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[189]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[358]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[359]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[37]

Drug(s) Affected By Max-interacting protein 1 (MXI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[134]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[134]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[282]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[331]

Drug(s) Affected By Cationic amino acid transporter 2 (SLC7A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[358]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]

Drug(s) Affected By CCAAT/enhancer-binding protein gamma (CEBPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[360]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[76]

Drug(s) Affected By Calcipressin-1 (RCAN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[361]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[362]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[361]

Drug(s) Affected By Solute carrier family 12 member 2 (SLC12A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[198]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[363]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Furosemide	DMMQ8ZG	Congestive heart failure	BD10	Approved	[363]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[198]

Drug(s) Affected By Proteinase-activated receptor 2 (F2RL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[364]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[365]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]

Drug(s) Affected By Methionine--tRNA ligase, cytoplasmic (MARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[366]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[367]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[47]

Drug(s) Affected By Gem-associated protein 4 (GEMIN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[246]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[368]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[369]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[370]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[371]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[372]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]

Drug(s) Affected By Ras-related protein Rab-5B (RAB5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[373]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[374]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[375]

Drug(s) Affected By Protein BTG1 (BTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[376]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[377]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[29]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[107]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[376]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]

Drug(s) Affected By Coxsackievirus and adenovirus receptor (CXADR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[378]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[378]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]

Drug(s) Affected By Phosphoserine phosphatase (PSPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[365]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[379]

Drug(s) Affected By Fractalkine (CX3CL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[179]
Fructose	DM43AN2	Vomiting	MD90	Approved	[380]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[86]

Drug(s) Affected By Protein jagged-1 (JAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[381]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[382]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[383]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[344]

Drug(s) Affected By C-C motif chemokine 20 (CCL20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[384]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[385]

Drug(s) Affected By C-X-C motif chemokine 6 (CXCL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[333]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[386]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[194]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[387]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[144]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[388]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[389]

Drug(s) Affected By Small ribosomal subunit protein bS6m (MRPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[367]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[390]

Drug(s) Affected By Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Selenium	DM25CGV	N. A.	N. A.	Approved	[175]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[25]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[25]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]

Drug(s) Affected By Disabled homolog 2 (DAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[391]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[392]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[318]

Drug(s) Affected By Transcriptional activator protein Pur-alpha (PURA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Haloperidol	DM96SE0	Delirium		Approved	[323]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[393]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[48]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]

Drug(s) Affected By Nuclear factor NF-kappa-B p100 subunit (NFKB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[220]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[343]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[394]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[395]

Drug(s) Affected By Transcription factor RelB (RELB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[396]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[342]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[397]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]

Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[296]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[358]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[398]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[296]

Drug(s) Affected By Pro-neuregulin-1, membrane-bound isoform (NRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[399]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 2 (TNFAIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[39]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[400]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Transducin-like enhancer protein 3 (TLE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[94]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By Lymphotoxin-beta (LTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[283]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[401]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[292]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[402]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[401]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[362]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[403]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[404]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[333]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[405]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[298]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[406]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[407]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[408]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[333]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[409]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[410]

Drug(s) Affected By Proline-rich nuclear receptor coactivator 1 (PNRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[331]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[360]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[411]

Drug(s) Affected By Tyrosine-protein kinase Mer (MERTK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[155]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[412]

Drug(s) Affected By Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[94]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[413]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[414]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[323]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[86]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[76]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[283]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[415]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[416]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[417]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[134]

Drug(s) Affected By TAR DNA-binding protein 43 (TARDBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[418]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[419]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[420]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[421]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Hexachlorophene	DMLKSE0	Bacterial infection	1A00-1C4Z	Approved	[422]

Drug(s) Affected By Serine/arginine-rich splicing factor 5 (SRSF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[424]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[251]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[323]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[323]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]

Drug(s) Affected By S-phase kinase-associated protein 2 (SKP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[425]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[426]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[427]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]

Drug(s) Affected By Interleukin-18 receptor 1 (IL18R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]
Bortezomib	DMNO38U	Leukemia		Approved	[428]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[429]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[430]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[47]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[431]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[432]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[433]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[434]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[435]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[242]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[436]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[300]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[364]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[435]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[257]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[437]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[215]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[408]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[376]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]

Drug(s) Affected By Squalene monooxygenase (SQLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[438]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[116]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[439]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]

Drug(s) Affected By Proteasome activator complex subunit 4 (PSME4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[189]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[379]

Drug(s) Affected By TNFAIP3-interacting protein 1 (TNIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[440]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[441]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[89]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[47]

Drug(s) Affected By Translocating chain-associated membrane protein 2 (TRAM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[442]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[48]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[47]

Drug(s) Affected By Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[395]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[234]
Ciprofibrate	DMGC5DB	Hyperlipoproteinemia	5C80	Approved	[443]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[444]
Sodium Acetate Anhydrous	DMH21E0	Hyponatraemia	5C72	Approved	[445]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase kappa (PTPRK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[446]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[86]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[379]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[447]

Drug(s) Affected By Delta(24)-sterol reductase (DHCR24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[448]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[116]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[449]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Transcription initiation factor TFIID subunit 11 (TAF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[450]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[112]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[451]

Drug(s) Affected By Methylsterol monooxygenase 1 (MSMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[116]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]

Drug(s) Affected By snRNA-activating protein complex subunit 1 (SNAPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]

Drug(s) Affected By Bcl-2-related protein A1 (BCL2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[452]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[322]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[453]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[454]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[39]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]

Drug(s) Affected By Cyclin-G2 (CCNG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[296]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[242]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[296]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[134]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]

Drug(s) Affected By Nuclear factor interleukin-3-regulated protein (NFIL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[425]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By Kynureninase (KYNU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[296]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[296]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Dual specificity protein phosphatase 6 (DUSP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[455]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[456]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[457]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[56]

Drug(s) Affected By Prolyl endopeptidase-like (PREPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[458]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[459]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[379]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[458]

Drug(s) Affected By Opioid growth factor receptor-like protein 1 (OGFRL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[194]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[460]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]

Drug(s) Affected By Muscleblind-like protein 2 (MBNL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[402]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[332]

Drug(s) Affected By KH homology domain-containing protein 4 (KHDC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[461]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[246]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[94]

Drug(s) Affected By Cilium assembly protein DZIP1 (DZIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[462]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[463]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[63]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[92]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]

Drug(s) Affected By Neuron navigator 2 (NAV2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[464]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]

Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 11 (GALNT11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[383]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By Nucleoporin Nup43 (NUP43)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[313]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[68]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[112]

Drug(s) Affected By Arginine/serine-rich protein PNISR (PNISR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[461]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Bortezomib	DMNO38U	Leukemia		Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[109]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX17 (DDX17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[465]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[107]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[134]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By Transcription factor GATA-6 (GATA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[333]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[466]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[333]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[333]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Indomethacin	DMSC4A7	Bursitis		Approved	[340]

Drug(s) Affected By Modulator of apoptosis 1 (MOAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[467]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[49]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[468]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[303]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[83]

Drug(s) Affected By Optineurin (OPTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[94]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[469]

Drug(s) Affected By Formin-binding protein 1 (FNBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[115]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[470]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[89]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[148]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[342]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[471]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[201]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[201]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[472]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[285]

Drug(s) Affected By Angiopoietin-related protein 4 (ANGPTL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[134]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[134]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[395]

Drug(s) Affected By Alpha-(1,6)-fucosyltransferase (FUT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]
Pyridoxal Phosphate	DMO2K0J	Malnutrition	5B50-5B71	Approved	[473]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]

Drug(s) Affected By Interferon-induced helicase C domain-containing protein 1 (IFIH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[328]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[39]

Drug(s) Affected By ER degradation-enhancing alpha-mannosidase-like protein 3 (EDEM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[78]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[313]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[78]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[38]

Drug(s) Affected By Egl nine homolog 1 (EGLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[474]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[318]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[56]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]

Drug(s) Affected By Ras-related protein Rab-33B (RAB33B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[49]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[66]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[38]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[109]

Drug(s) Affected By Sodium-coupled neutral amino acid symporter 1 (SLC38A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[475]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]

Drug(s) Affected By Pinin (PNN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[476]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[476]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[37]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[76]

Drug(s) Affected By Protein salvador homolog 1 (SAV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[49]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[95]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[194]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[112]

Drug(s) Affected By Pantothenate kinase 3 (PANK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[373]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[477]

Drug(s) Affected By Putative divalent cation/proton antiporter TMEM165 (TMEM165)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[95]

Drug(s) Affected By Magnesium transporter MRS2 homolog, mitochondrial (MRS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[478]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[112]

Drug(s) Affected By Transcriptional and immune response regulator (TCIM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[479]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By GTP-binding protein SAR1a (SAR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[76]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[92]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[480]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[375]

Drug(s) Affected By RNA-binding protein 12 (RBM12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[246]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[481]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[482]

Drug(s) Affected By Protein lin-7 homolog C (LIN7C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[301]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[92]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]

Drug(s) Affected By E3 ubiquitin-protein ligase FANCL (FANCL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[75]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[115]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[148]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[381]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[483]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[125]

Drug(s) Affected By DnaJ homolog subfamily B member 9 (DNAJB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[213]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[397]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[126]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[134]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[334]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[134]

Drug(s) Affected By DnaJ homolog subfamily B member 4 (DNAJB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[164]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[242]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[484]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[397]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[126]

Drug(s) Affected By Testin (TES)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[251]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[323]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 13 (MED13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[411]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[115]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[47]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[115]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[67]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[94]

Drug(s) Affected By Dachshund homolog 1 (DACH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[485]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[486]
Napabucasin	DMDZ6Q3	Colorectal cancer	2B91.Z	Phase 3	[487]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]

Drug(s) Affected By GTP:AMP phosphotransferase AK3, mitochondrial (AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[134]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[134]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[379]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]

Drug(s) Affected By Testis-specific Y-encoded-like protein 4 (TSPYL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[390]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[49]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[80]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]

Drug(s) Affected By Cell division cycle protein 23 homolog (CDC23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[488]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Bortezomib	DMNO38U	Leukemia		Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By Protein TASOR (TASOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[45]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[115]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]

Drug(s) Affected By Protein fem-1 homolog B (FEM1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[34]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[313]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[390]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[451]

Drug(s) Affected By A-kinase anchor protein 11 (AKAP11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[402]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[194]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[313]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[47]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[49]

Drug(s) Affected By F-box/WD repeat-containing protein 2 (FBXW2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Indomethacin	DMSC4A7	Bursitis		Approved	[340]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[63]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[133]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]

Drug(s) Affected By Endoribonuclease Dicer (DICER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[489]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[195]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[52]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[25]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[45]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[25]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[25]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[258]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[242]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[25]

Drug(s) Affected By Ectonucleoside triphosphate diphosphohydrolase 4 (ENTPD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[115]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[115]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[490]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[109]

Drug(s) Affected By Lysine-specific demethylase 3A (KDM3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[364]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[134]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]

Drug(s) Affected By Mitochondrial import inner membrane translocase subunit Tim10 B (TIMM10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[478]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[49]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[491]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[492]

Drug(s) Affected By Phosphoserine aminotransferase (PSAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[126]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[134]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[395]

Drug(s) Affected By EP300-interacting inhibitor of differentiation 1 (EID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[76]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[48]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[95]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[493]
bilirubin	DMI0V4O	Discovery agent	N.A.	Investigative	[494]

Drug(s) Affected By Sodium bicarbonate cotransporter 3 (SLC4A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[461]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]

Drug(s) Affected By Roundabout homolog 1 (ROBO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[495]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[379]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[496]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[63]

Drug(s) Affected By Importin subunit alpha-3 (KPNA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[323]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[497]
Haloperidol	DM96SE0	Delirium		Approved	[323]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[323]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[323]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]

Drug(s) Affected By Dickkopf-related protein 1 (DKK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[498]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[382]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By G2/mitotic-specific cyclin-B2 (CCNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[425]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[499]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[500]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]

Drug(s) Affected By Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[501]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[502]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[503]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[134]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]

Drug(s) Affected By Securin (PTTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[504]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[200]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]

Drug(s) Affected By Putative lipid scramblase CLPTM1 (CLPTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Bortezomib	DMNO38U	Leukemia		Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[505]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[49]

Drug(s) Affected By Antithrombin-III (SERPINC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[506]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[507]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Aminocaproic Acid	DMFGND4	Bleeding disorder	GA20-GA21	Approved	[506]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[508]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[509]

Drug(s) Affected By Alpha-galactosidase A (GLA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[510]
Bortezomib	DMNO38U	Leukemia		Approved	[34]

Drug(s) Affected By Furin (FURIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[511]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[512]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[513]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[514]

Drug(s) Affected By Osteopontin (SPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[515]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[516]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[517]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[407]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[518]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[501]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[398]

Drug(s) Affected By Coagulation factor V (F5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[519]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[520]

Drug(s) Affected By Protein disulfide-isomerase A4 (PDIA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[379]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[521]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[522]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[390]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[78]

Drug(s) Affected By Farnesyl pyrophosphate synthase (FDPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[523]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[439]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[118]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]

Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[524]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[525]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[525]

Drug(s) Affected By Fos-related antigen 1 (FOSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[213]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[500]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[343]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[526]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[251]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]

Drug(s) Affected By Gastricsin (PGC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]

Drug(s) Affected By Nuclear transcription factor Y subunit alpha (NFYA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[527]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[528]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[75]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[529]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[159]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[434]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[530]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[531]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[532]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[533]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]

Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[534]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[535]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[500]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[397]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]

Drug(s) Affected By Leukocyte elastase inhibitor (SERPINB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[222]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[536]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[285]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[322]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 1 (ACSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[537]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[538]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[134]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[134]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]

Drug(s) Affected By Cyclin-dependent kinases regulatory subunit 2 (CKS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[500]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[251]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]

Drug(s) Affected By Glutaredoxin-1 (GLRX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[463]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[379]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]

Drug(s) Affected By Vitamin K-dependent gamma-carboxylase (GGCX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[390]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[48]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[92]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[539]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[83]

Drug(s) Affected By Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Haloperidol	DM96SE0	Delirium		Approved	[323]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[323]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[323]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[194]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[151]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[336]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[210]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[540]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[309]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[541]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[542]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[543]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[148]

Drug(s) Affected By Lanosterol synthase (LSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[188]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[544]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[188]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[188]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[190]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[188]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[545]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[544]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[546]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[547]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[548]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[549]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[333]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[550]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[551]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[298]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[552]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[501]

Drug(s) Affected By Ras-related protein Rab-9A (RAB9A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[510]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[379]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[390]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[133]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[303]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[94]

Drug(s) Affected By Serine/threonine-protein kinase SIK1 (SIK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[134]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[466]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[134]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[134]

Drug(s) Affected By Histone H4 (H4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[553]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]

Drug(s) Affected By Nucleobindin-2 (NUCB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[251]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[554]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[194]

Drug(s) Affected By Serine/arginine-rich splicing factor 2 (SRSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[331]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[360]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[555]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[76]

Drug(s) Affected By Krueppel-like factor 10 (KLF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[155]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[556]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[360]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]

Drug(s) Affected By Syntaxin-3 (STX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[459]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[155]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[331]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[463]

Drug(s) Affected By Centromere protein R (ITGB3BP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[283]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[344]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]

Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[557]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[188]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[364]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[544]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[188]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[190]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[558]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[188]

Drug(s) Affected By Thiosulfate sulfurtransferase (TST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[194]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[37]

Drug(s) Affected By Pleckstrin homology-like domain family A member 2 (PHLDA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[462]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]

Drug(s) Affected By Immunoglobulin superfamily member 1 (IGSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[442]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[47]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[559]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[560]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[561]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[562]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[436]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[563]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[564]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[565]

Drug(s) Affected By Tribbles homolog 1 (TRIB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]

Drug(s) Affected By G-protein coupled estrogen receptor 1 (GPER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[566]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[342]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[566]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[155]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[567]

Drug(s) Affected By Selenide, water dikinase 2 (SEPHS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[568]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[92]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[569]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[133]

Drug(s) Affected By Krueppel-like factor 6 (KLF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[570]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[148]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[283]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]

Drug(s) Affected By Immediate early response gene 2 protein (IER2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[571]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[107]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[463]

Drug(s) Affected By Rac GTPase-activating protein 1 (RACGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[189]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[283]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[572]

Drug(s) Affected By Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase (ST6GALNAC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[573]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[574]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[50]

Drug(s) Affected By Transcription factor MafF (MAFF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[52]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[575]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[213]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[576]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[577]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[578]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[579]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[580]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[164]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[581]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[227]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[582]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[583]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[584]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[584]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[584]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[585]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[586]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[587]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[588]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[589]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[590]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[159]

Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[591]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[592]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[365]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[591]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[592]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[593]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[594]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[595]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[596]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[597]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[333]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[591]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[598]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[599]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[600]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[601]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[602]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]

Drug(s) Affected By NADPH oxidase 1 (NOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[331]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[603]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[604]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[604]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[605]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[604]
Acteoside	DM0YHKB	Nephritis	GB40	Terminated	[606]
U0126	DM31OGF	Discovery agent	N.A.	Investigative	[607]

Drug(s) Affected By Metallothionein-2 (MT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[608]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[284]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[609]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[164]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[251]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]

Drug(s) Affected By Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[225]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[610]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[234]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[611]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[63]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[612]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[613]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[614]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[615]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[616]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[617]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[618]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[619]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[620]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[434]

Drug(s) Affected By Histone-lysine N-methyltransferase 2A (KMT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[621]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[622]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[623]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[624]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[625]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]

Drug(s) Affected By IQ motif and SEC7 domain-containing protein 1 (IQSEC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[38]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[626]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[481]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]

Drug(s) Affected By Krueppel-like factor 4 (KLF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[627]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[628]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[629]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[338]

Drug(s) Affected By Aldehyde dehydrogenase 1A1 (ALDH1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[592]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[425]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[630]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[462]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[343]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[631]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[632]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[633]
Haloperidol	DM96SE0	Delirium		Approved	[159]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[333]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[210]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[634]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[635]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[636]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[289]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[637]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[638]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[24]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[639]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[237]
Selenium	DM25CGV	N. A.	N. A.	Approved	[640]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[641]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[642]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[298]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[643]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[644]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[296]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Selenium	DM25CGV	N. A.	N. A.	Approved	[645]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[592]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[646]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[647]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[627]

Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[648]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[649]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[650]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[383]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[651]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[652]

Drug(s) Affected By Transcription factor SOX-2 (SOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[204]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[592]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[653]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[627]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[654]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[655]

Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[592]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[656]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[627]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[657]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[658]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[659]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[660]

Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[307]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[661]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[662]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[663]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]

Drug(s) Affected By DNA mismatch repair protein Mlh1 (MLH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[286]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[664]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[665]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[666]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[667]

Drug(s) Affected By DNA ligase 4 (LIG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[251]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[402]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Bortezomib	DMNO38U	Leukemia		Approved	[34]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[668]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[477]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[49]
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[669]

Drug(s) Affected By DNA-dependent protein kinase catalytic subunit (PRKDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[189]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[407]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[670]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[671]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]

Drug(s) Affected By DNA repair protein RAD51 homolog 1 (RAD51)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[672]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[673]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[327]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[674]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]

Drug(s) Affected By Fanconi anemia group D2 protein (FANCD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[425]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[675]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]

Drug(s) Affected By Non-homologous end-joining factor 1 (NHEJ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[676]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[94]

Drug(s) Affected By Toll-like receptor 4 (TLR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[677]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[678]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[385]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[316]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[677]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[134]

Drug(s) Affected By C-C motif chemokine 22 (CCL22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[679]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[384]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[659]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[680]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[681]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[682]
MLN4924	DMP36KD	Myelodysplastic syndrome	2A37	Phase 3	[683]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[431]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[530]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[684]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[685]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[530]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[686]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[687]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[688]

Drug(s) Affected By Lysine-specific demethylase 6B (KDM6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[331]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[47]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[49]

Drug(s) Affected By Protein Mdm4 (MDM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[97]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[689]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]

Drug(s) Affected By Tumor protein p73 (TP73)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[690]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[541]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[436]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[338]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[97]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[691]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[541]

Drug(s) Affected By Protein sprouty homolog 2 (SPRY2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[344]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]

Drug(s) Affected By Protein sprouty homolog 1 (SPRY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[134]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[692]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[416]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[29]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]

Drug(s) Affected By Liprin-alpha-4 (PPFIA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[693]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[366]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[63]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[47]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[48]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[573]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[694]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]

Drug(s) Affected By CCN family member 5 (CCN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[24]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[39]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[39]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[695]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[64]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[90]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[390]

Drug(s) Affected By Protein FAM13A (FAM13A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[318]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[696]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[697]

Drug(s) Affected By C-X-C motif chemokine 14 (CXCL14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[75]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[346]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Indomethacin	DMSC4A7	Bursitis		Approved	[698]

Drug(s) Affected By EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[75]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[699]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[36]

Drug(s) Affected By Reversion-inducing cysteine-rich protein with Kazal motifs (RECK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[700]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[459]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[344]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[463]

Drug(s) Affected By L-lactate dehydrogenase A chain (LDHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[159]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[701]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[107]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[322]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[421]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[702]

Drug(s) Affected By Ceruloplasmin (CP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[703]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[278]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[704]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[46]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[705]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[308]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[706]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[707]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[708]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[709]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Selenium	DM25CGV	N. A.	N. A.	Approved	[640]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[710]

Drug(s) Affected By Phosphoglycerate kinase 1 (PGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[711]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[274]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[421]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[702]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By Cystatin-A (CSTA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[295]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[381]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[225]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[242]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[712]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[713]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[220]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[295]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[714]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Selenium	DM25CGV	N. A.	N. A.	Approved	[319]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[311]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[715]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[716]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[717]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[159]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[511]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[718]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[719]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[238]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[720]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[721]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[722]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[723]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[724]
Fructose	DM43AN2	Vomiting	MD90	Approved	[159]
Ketoprofen	DMRKXPT	Bursitis		Approved	[159]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[725]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[404]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[726]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[639]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[727]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[237]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[25]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[25]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[237]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[25]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[291]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[206]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[221]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[25]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[634]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[25]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[728]
Selenium	DM25CGV	N. A.	N. A.	Approved	[175]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[729]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[730]

Drug(s) Affected By Fibronectin (FN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[731]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[342]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[732]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[733]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[734]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[735]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[736]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[417]

Drug(s) Affected By C-X-C motif chemokine 10 (CXCL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[737]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[738]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[739]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[439]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[740]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]

Drug(s) Affected By Transferrin receptor protein 1 (TFRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[210]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[741]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[677]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[742]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[743]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[744]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[745]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[307]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[746]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[747]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[707]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[600]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[748]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[749]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[747]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[567]

Drug(s) Affected By Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[279]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[742]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[274]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[702]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[323]

Drug(s) Affected By Interleukin-5 (IL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[737]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[750]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[751]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[720]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[752]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[216]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[753]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[754]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[755]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[756]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[757]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[758]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[759]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[760]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[761]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[762]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[213]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[355]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[39]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[763]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[204]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[235]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[237]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[728]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[545]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[764]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[765]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[766]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[309]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[715]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[767]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[768]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[769]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[149]

Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[770]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[771]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[772]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[773]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[774]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[629]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[775]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[776]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[777]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]

Drug(s) Affected By Annexin A2 (ANXA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[778]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[779]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[780]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[781]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[782]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[783]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[784]
Selenium	DM25CGV	N. A.	N. A.	Approved	[640]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[785]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[786]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[787]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[788]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[789]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[790]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[791]

Drug(s) Affected By Insulin-like growth factor-binding protein 1 (IGFBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[24]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[792]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[793]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[500]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[794]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[795]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[435]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[796]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[543]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[796]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[642]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[797]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[798]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[799]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[800]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[801]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[204]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[276]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[206]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[25]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[634]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[802]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[25]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[803]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[804]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[805]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[806]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[159]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[807]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[808]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[404]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[306]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[407]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[809]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[810]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[323]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[811]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[811]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[358]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[210]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[812]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[737]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[813]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[738]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[814]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[815]

Drug(s) Affected By Prolyl 4-hydroxylase subunit alpha-1 (P4HA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[495]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[414]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[134]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[134]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]

Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[742]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[408]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[816]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[227]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]

Drug(s) Affected By Insulin-like growth factor-binding protein 3 (IGFBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Selenium	DM25CGV	N. A.	N. A.	Approved	[817]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[381]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[818]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[201]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[501]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[819]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[820]

Drug(s) Affected By Transcription factor PU.1 (SPI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[225]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[821]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[822]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[823]
Pomalidomide	DMTGBAX	Plasma cell myeloma	2A83.1	Approved	[824]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[825]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[626]

Drug(s) Affected By Erythropoietin receptor (EPOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[286]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[826]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[827]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[195]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[246]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By Endothelin-2 (EDN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[828]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[332]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[366]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[829]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]

Drug(s) Affected By Cytoplasmic aconitate hydratase (ACO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[830]
Trabectedin	DMG3Y89	Leiomyosarcoma	2B58	Approved	[831]

Drug(s) Affected By Kit ligand (KITLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[291]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[382]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[737]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[751]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[535]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[832]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[833]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[834]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[835]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[202]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[739]

Drug(s) Affected By C-C motif chemokine 1 (CCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[384]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[345]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[836]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[429]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[315]
ACYLINE	DM9GRTK	Prostate cancer	2C82.0	Phase 2	[837]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[838]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[431]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[839]

Drug(s) Affected By Nuclear autoantigen Sp-100 (SP100)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[94]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[220]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[286]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[840]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[841]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[399]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[842]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[843]

Drug(s) Affected By C-X-C chemokine receptor type 1 (CXCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[844]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[845]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[846]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[847]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[848]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[849]
PBI-05204	DM05WIU	Pancreatic cancer	2C10	Phase 2	[850]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[38]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[851]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[852]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[853]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[854]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[855]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[404]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[856]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[857]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[858]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[859]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[679]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[560]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[860]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[854]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[861]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[862]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[863]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[853]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[159]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[404]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[856]

Drug(s) Affected By Beta-arrestin-2 (ARRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[864]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[865]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Methamphetamine	DMPM4SK	Anxiety		Approved	[866]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[867]

Drug(s) Affected By C-C chemokine receptor type 7 (CCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[107]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[868]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[869]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[868]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[36]

Drug(s) Affected By Cystathionine gamma-lyase (CTH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[126]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[134]

Drug(s) Affected By T-lymphocyte activation antigen CD80 (CD80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[870]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[871]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[872]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[873]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[868]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[874]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[868]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[875]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[876]

Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Indomethacin	DMSC4A7	Bursitis		Approved	[289]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[877]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[878]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[879]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[880]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[164]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[408]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[527]

Drug(s) Affected By Malate dehydrogenase, mitochondrial (MDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[782]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[881]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[66]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[38]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[492]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[83]

Drug(s) Affected By N-alpha-acetyltransferase 10 (NAA10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[323]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[379]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]

Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[882]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[737]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[883]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[677]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[883]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[883]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[765]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[308]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[542]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[884]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[885]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[707]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[886]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[887]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[888]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[889]

Drug(s) Affected By Stromal cell-derived factor 1 (CXCL12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[333]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[296]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[890]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[296]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[382]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[891]

Drug(s) Affected By Isocitrate dehydrogenase , mitochondrial (IDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[560]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[395]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[892]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[893]

Drug(s) Affected By C-X-C chemokine receptor type 3 (CXCR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[159]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[894]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[895]
MLN4924	DMP36KD	Myelodysplastic syndrome	2A37	Phase 3	[683]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[851]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[605]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[50]

Drug(s) Affected By Hexokinase-2 (HK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[896]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[897]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[898]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[899]

Drug(s) Affected By Stanniocalcin-1 (STC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[351]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[365]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[318]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[638]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[900]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[901]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[902]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[902]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[279]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[903]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[260]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[904]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[905]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[808]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[906]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[877]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[435]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[907]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[908]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[909]

Drug(s) Affected By DnaJ homolog subfamily B member 13 (DNAJB13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[94]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[910]

Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[911]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[912]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[593]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[913]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[914]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[915]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[782]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]

Drug(s) Affected By Protein BTG2 (BTG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[916]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[917]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[500]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[125]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[107]

Drug(s) Affected By C-C motif chemokine 7 (CCL7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[384]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[384]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[918]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[315]
Abexinostat	DM91LGU	Follicular lymphoma	2A80	Phase 3	[919]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[514]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[450]

Drug(s) Affected By Metallothionein-1X (MT1X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[920]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[921]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[921]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[922]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[923]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[924]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[925]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[306]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[662]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[290]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[533]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[926]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[927]

Drug(s) Affected By 1,4-alpha-glucan-branching enzyme (GBE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[351]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[134]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[134]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[194]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[928]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[929]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[56]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[245]

Drug(s) Affected By Interleukin-27 subunit beta (EBI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[329]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[930]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[931]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[315]

Drug(s) Affected By Interferon regulatory factor 3 (IRF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[366]
Hydroxychloroquine	DMSIVND	Chronic renal failure	GB61.Z	Approved	[929]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[932]

Drug(s) Affected By kinase isozyme 1, mitochondrial (PDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[134]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[933]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[934]

Drug(s) Affected By Mothers against decapentaplegic homolog 1 (SMAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[894]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[159]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[935]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[936]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[205]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[634]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[54]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[937]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[938]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[939]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[936]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[535]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[940]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[500]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[941]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[942]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[943]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[944]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[945]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[946]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[946]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[317]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[947]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[896]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[407]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[116]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[948]

Drug(s) Affected By Histone H3.1t (H3-4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[949]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[950]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[553]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[951]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[952]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[953]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[246]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[954]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[955]

Drug(s) Affected By Carbonic anhydrase 9 (CA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[956]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[317]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[957]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Bortezomib	DMNO38U	Leukemia		Approved	[958]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]

Drug(s) Affected By 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[439]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[134]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[318]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[56]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]

Drug(s) Affected By Glycerol-3-phosphate acyltransferase 3 (GPAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[364]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[134]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[134]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[503]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]

Drug(s) Affected By Interferon-induced protein 44-like (IFI44L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[39]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]

Drug(s) Affected By Kelch-like protein 24 (KLHL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[242]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]

Drug(s) Affected By CD109 antigen (CD109)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]

Drug(s) Affected By Lysine-specific demethylase 7A (KDM7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[425]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[331]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]

Drug(s) Affected By Ankyrin repeat domain-containing protein 37 (ANKRD37)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[46]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[47]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 3B (PPP1R3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[331]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[31]

Drug(s) Affected By CREB3 regulatory factor (CREBRF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[397]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[461]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[50]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[331]

Drug(s) Affected By N-acetylaspartylglutamate synthase A (RIMKLA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[573]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]

Drug(s) Affected By Histone H2B type 3-B (H2BC26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[459]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[37]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[959]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[694]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[112]

Drug(s) Affected By T-complex protein 11-like protein 2 (TCP11L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[331]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[344]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[246]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[390]

Drug(s) Affected By Arrestin domain-containing protein 4 (ARRDC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[960]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[961]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[46]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]

Drug(s) Affected By Interleukin-27 subunit alpha (IL27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[962]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[676]

Drug(s) Affected By Transmembrane protein 158 (TMEM158)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[246]

Drug(s) Affected By Protein NDRG1 (NDRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[237]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[963]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[662]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[351]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[331]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]

Drug(s) Affected By Fibroblast growth factor 11 (FGF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[459]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[894]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[47]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[49]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[605]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[93]

Drug(s) Affected By Interferon regulatory factor 7 (IRF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[964]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[740]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[155]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[39]

Drug(s) Affected By Thymic stromal lymphopoietin (TSLP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[556]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[196]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[965]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By F-box only protein 32 (FBXO32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[344]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[556]

Drug(s) Affected By Phosphoinositide-3-kinase-interacting protein 1 (PIK3IP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Idelalisib	DM602WT	Chronic lymphocytic leukaemia	2A82.0	Approved	[966]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[56]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[435]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[257]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[967]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[283]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[408]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[401]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[968]

Drug(s) Affected By Perilipin-2 (PLIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[381]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[134]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[969]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[395]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Aconitate hydratase, mitochondrial (ACO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[226]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[234]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[478]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[970]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By Myeloid differentiation primary response protein MyD88 (MYD88)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[351]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[355]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[56]

Drug(s) Affected By Cbp/p300-interacting transactivator 2 (CITED2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[495]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]

Drug(s) Affected By Apolipoprotein L2 (APOL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[971]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[49]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[375]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[972]
Manganese	DMKT129	N. A.	N. A.	Investigative	[973]

Drug(s) Affected By Normal mucosa of esophagus-specific gene 1 protein (C15ORF48)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[974]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[144]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[315]

Drug(s) Affected By C-X-C motif chemokine 16 (CXCL16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[975]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[365]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[244]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[72]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[894]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[246]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[676]

Drug(s) Affected By Tumor protein 63 (TP63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[976]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[977]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[978]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[466]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[979]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]

Drug(s) Affected By Prolyl hydroxylase EGLN3 (EGLN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[699]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[195]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[31]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[47]

Drug(s) Affected By Tensin-1 (TNS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[980]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[31]

Drug(s) Affected By Cytokine receptor-like factor 2 (CRLF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[894]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[981]

Drug(s) Affected By Triggering receptor expressed on myeloid cells 1 (TREM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[195]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[90]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[982]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[851]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[514]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[51]

Drug(s) Affected By Sperm-associated antigen 4 protein (SPAG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[442]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[49]

Drug(s) Affected By Transmembrane protein 45A (TMEM45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[331]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[134]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[195]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[983]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha inhibitor (HIF1AN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[704]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[918]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[38]
CLIOQUINOL	DM746BZ	N. A.	N. A.	Withdrawn from market	[984]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[68]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[112]

Drug(s) Affected By Interleukin-1 receptor-associated kinase 4 (IRAK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[985]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[986]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[63]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[986]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By C-type lectin domain family 5 member A (CLEC5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[851]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[838]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[450]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 3C (PPP1R3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[364]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[155]

Drug(s) Affected By TNF receptor-associated factor 6 (TRAF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[498]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[355]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[123]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[394]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[987]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[988]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[989]

Drug(s) Affected By Hypoxia-inducible lipid droplet-associated protein (HILPDA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[39]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[495]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[990]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[991]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[368]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[306]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[992]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[993]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[994]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[160]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[311]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[634]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[995]
Haloperidol	DM96SE0	Delirium		Approved	[159]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[996]
Selenium	DM25CGV	N. A.	N. A.	Approved	[997]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[998]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[999]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1000]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1001]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[924]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1002]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[615]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1003]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[1004]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[368]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[1005]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1006]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[368]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1007]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[435]
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1008]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[921]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1009]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[291]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[164]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated calcium channel alpha Cav3.1 (CACNA1G)	TT729IR	CAC1G_HUMAN	Blocker	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1,4-alpha-glucan-branching enzyme (GBE1)	OTK2N05B	GLGB_HUMAN	Gene/Protein Processing	[2]
26S proteasome non-ATPase regulatory subunit 12 (PSMD12)	OTWICA51	PSD12_HUMAN	Gene/Protein Processing	[3]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[3]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)	OT25JBA3	F263_HUMAN	Gene/Protein Processing	[3]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)	OTQYEXL2	F264_HUMAN	Gene/Protein Processing	[4]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[5]
A-kinase anchor protein 11 (AKAP11)	OT7E2FVD	AKA11_HUMAN	Gene/Protein Processing	[3]
Aconitate hydratase, mitochondrial (ACO2)	OTF2UVNV	ACON_HUMAN	Gene/Protein Processing	[6]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[7]
Actin, cytoplasmic 1 (ACTB)	OT1MCP2F	ACTB_HUMAN	Gene/Protein Processing	[8]

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