Details of the Drug Combination

General Information of Drug Combination (ID: DCR9A1J)

• Drug Combination Name: Dexamethasone + MK-4827
• Indication: Ovarian serous cystadenocarcinoma; Status: Investigative [1]
• Component Drugs:
  Dexamethasone (DMMWZET): Small molecular drug
  MK-4827 (DMLYGH4): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: SK-OV-3
  Zero Interaction Potency (ZIP) Score: 2.62
  Bliss Independence Score: 5.78
  Loewe Additivity Score: 6.35
  LHighest Single Agent (HSA) Score: 11.51

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Dexamethasone

Disease Entry	ICD 11	Status	REF
Acute adrenal insufficiency	N.A.	Approved	[2]
Acute asthma	CA23	Approved	[2]
Addison disease	5A74.0	Approved	[2]
Allergic otitis media	N.A.	Approved	[2]
Allergic rhinitis	CA08.0	Approved	[2]
Angioedema	4A00.15	Approved	[2]
Articular cartilage disorder	FA34.Y	Approved	[2]
Autoimmune haemolytic anaemia	3A20	Approved	[2]
Blepharoconjunctivitis	N.A.	Approved	[2]
Burkitt lymphoma	N.A.	Approved	[2]
Bursitis	N.A.	Approved	[2]
Central retinal vein occlusion with macular edema	N.A.	Approved	[2]
Cerebral edema	8D60.1	Approved	[2]
Congenital adrenal hyperplasia	5A71.01	Approved	[2]
Corneal abrasion	NA06.4	Approved	[2]
Corneal ulcer	9A76	Approved	[2]
Crohn disease	DD70	Approved	[2]
Dermatitis herpetiformis	EB44	Approved	[2]
Diamond-Blackfan anemia	N.A.	Approved	[2]
Disorder of orbital region	N.A.	Approved	[2]
Epicondylitis	N.A.	Approved	[2]
Erythema multiforme	N.A.	Approved	[2]
Exanthem	N.A.	Approved	[2]
Granuloma annulare	N.A.	Approved	[2]
Inflammatory bowel disease	DD72	Approved	[2]
Keratitis	N.A.	Approved	[2]
Liver cirrhosis	DB93.1	Approved	[2]
Lung cancer	2C25.0	Approved	[2]
Malignant otitis externa caused by Pseudomonas aeruginosa	N.A.	Approved	[2]
Miliary tuberculosis	N.A.	Approved	[2]
Multiple sclerosis	8A40	Approved	[2]
Mycosis fungoides	2B01	Approved	[2]
Nausea	MD90	Approved	[2]
Plasma cell myeloma	2A83.1	Approved	[2]
Primary cutaneous T-cell lymphoma	N.A.	Approved	[2]
Psoriasis	EA90	Approved	[2]
Psoriatic arthritis	FA21	Approved	[2]
Rheumatic heart disease	N.A.	Approved	[2]
Rheumatoid arthritis	FA20	Approved	[3]
Rosacea	ED90.0	Approved	[2]
Sarcoidosis	4B20.5	Approved	[2]
Serum sickness	N.A.	Approved	[2]
Skin disease	EA00-EM0Z	Approved	[2]
Systemic lupus erythematosus	4A40.0	Approved	[2]
Vomiting	MD90	Approved	[2]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2/3	[4]
Acquired thrombocytopenia	N.A.	Investigative	[2]
Asthma	CA23	Investigative	[2]
B-cell neoplasm	N.A.	Investigative	[2]
Beta-thalassemia major	N.A.	Investigative	[2]
Classic Hodgkin lymphoma	N.A.	Investigative	[2]
Follicular lymphoma	2A80	Investigative	[2]
Iridocyclitis	N.A.	Investigative	[2]
Keloid	EE60	Investigative	[2]
Trichinellosis	N.A.	Investigative	[2]
Uveitis	9A96.Z	Investigative	[2]

Dexamethasone Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Glucocorticoid receptor (NR3C1)	TTYRL6O	GCR_HUMAN	Agonist	[16]

Dexamethasone Interacts with 2 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[17]
Peptide transporter 1 (SLC15A1)	DT9G7XN	S15A1_HUMAN	Substrate	[18]

Dexamethasone Interacts with 5 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[19]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[20]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Metabolism	[21]
Carboxylesterase 2 (CES2)	DETHCPD	EST2_HUMAN	Metabolism	[22]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2)	DEDH7FP	DHI2_HUMAN	Metabolism	[23]

Dexamethasone Interacts with 979 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Increases Expression	[24]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)	OTHF4H9U	DHI2_HUMAN	Increases Expression	[25]
Cytochrome P450 3A5 (CYP3A5)	OTSXFBXB	CP3A5_HUMAN	Increases Expression	[26]
Cytochrome P450 3A7 (CYP3A7)	OTTCDHHM	CP3A7_HUMAN	Increases Expression	[27]
Cocaine esterase (CES2)	OTC647SQ	EST2_HUMAN	Increases Expression	[28]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Increases Expression	[29]
Nuclear factor NF-kappa-B p105 subunit (NFKB1)	OTNRRD8I	NFKB1_HUMAN	Increases Expression	[9]
Haptoglobin (HP)	OTGUGAF9	HPT_HUMAN	Increases Expression	[9]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Increases Expression	[9]
Thrombomodulin (THBD)	OT8VHLKY	TRBM_HUMAN	Decreases Expression	[10]
Interleukin-4 (IL4)	OTOXBWAU	IL4_HUMAN	Decreases Expression	[30]
Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4)	OTJZG0LD	GLUT4_HUMAN	Affects Expression	[31]
Ribosomal protein S6 kinase beta-1 (RPS6KB1)	OTAELNGX	KS6B1_HUMAN	Decreases Phosphorylation	[32]
TSC22 domain family protein 3 (TSC22D3)	OT03UM03	T22D3_HUMAN	Increases Expression	[33]
Signal transducer and activator of transcription 3 (STAT3)	OTAAGKYZ	STAT3_HUMAN	Increases ADR	[34]
C-Jun-amino-terminal kinase-interacting protein 1 (MAPK8IP1)	OTDAWAUZ	JIP1_HUMAN	Increases ADR	[34]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Response To Substance	[35]
Endothelin-1 (EDN1)	OTZCACEG	EDN1_HUMAN	Decreases Expression	[36]
Nitric oxide synthase, inducible (NOS2)	OTKKIOJ1	NOS2_HUMAN	Decreases Expression	[36]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Increases Expression	[7]
Gasdermin-E (GSDME)	OT1ZWY32	GSDME_HUMAN	Increases Expression	[7]
Protein arginine N-methyltransferase 3 (PRMT3)	OTH2KILE	ANM3_HUMAN	Decreases Expression	[7]
GRB2-related adapter protein 2 (GRAP2)	OTS5NIZ3	GRAP2_HUMAN	Increases Expression	[7]
AP-1 complex subunit gamma-like 2 (AP1G2)	OTTJ7NXL	AP1G2_HUMAN	Increases Expression	[7]
Cell cycle checkpoint protein RAD17 (RAD17)	OT1I93DT	RAD17_HUMAN	Decreases Expression	[7]
Endonuclease domain-containing 1 protein (ENDOD1)	OTME0ZW5	ENDD1_HUMAN	Decreases Expression	[7]
Rho-related BTB domain-containing protein 3 (RHOBTB3)	OT1BFKPH	RHBT3_HUMAN	Increases Expression	[7]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[7]
Serglycin (SRGN)	OTFAVSX0	SRGN_HUMAN	Increases Expression	[7]
Integrin alpha-4 (ITGA4)	OTSCAL0V	ITA4_HUMAN	Decreases Expression	[7]
V(D)J recombination-activating protein 1 (RAG1)	OTV131E4	RAG1_HUMAN	Decreases Expression	[7]
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PPP3CB)	OTEGNEHW	PP2BB_HUMAN	Decreases Expression	[7]
Interleukin-7 receptor subunit alpha (IL7R)	OTBMFLQQ	IL7RA_HUMAN	Increases Expression	[7]
Leukocyte surface antigen CD53 (CD53)	OT9U5OXJ	CD53_HUMAN	Increases Expression	[7]
Receptor-type tyrosine-protein phosphatase mu (PTPRM)	OTCEL6PN	PTPRM_HUMAN	Increases Expression	[7]
Inositol polyphosphate 1-phosphatase (INPP1)	OTHSJCRQ	INPP_HUMAN	Increases Expression	[7]
C-C chemokine receptor type 4 (CCR4)	OT68KZ9B	CCR4_HUMAN	Increases Expression	[7]
Calcipressin-1 (RCAN1)	OT1MVXC7	RCAN1_HUMAN	Increases Expression	[7]
Protein BTG1 (BTG1)	OTVJ2CDM	BTG1_HUMAN	Increases Expression	[7]
Protein BTG2 (BTG2)	OTZF6K1H	BTG2_HUMAN	Increases Expression	[7]
Microtubule-associated protein 1A (MAP1A)	OTHO8K43	MAP1A_HUMAN	Increases Expression	[7]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)	OTCO26FV	HMCS1_HUMAN	Decreases Expression	[7]
Transducin-like enhancer protein 4 (TLE4)	OT4QEH6T	TLE4_HUMAN	Decreases Expression	[7]
Synaptic vesicular amine transporter (SLC18A2)	OTUOMMM6	VMAT2_HUMAN	Increases Expression	[7]
Amidophosphoribosyltransferase (PPAT)	OTXK12ZB	PUR1_HUMAN	Decreases Expression	[7]
Lymphotoxin-beta (LTB)	OTUFS8CF	TNFC_HUMAN	Decreases Expression	[7]
Early activation antigen CD69 (CD69)	OTGJHSVP	CD69_HUMAN	Increases Expression	[7]
Src-like-adapter (SLA)	OTV17DY2	SLAP1_HUMAN	Increases Expression	[7]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Increases Expression	[7]
Four and a half LIM domains protein 1 (FHL1)	OTN535SU	FHL1_HUMAN	Increases Expression	[7]
Protein-tyrosine kinase 2-beta (PTK2B)	OTGAS0I8	FAK2_HUMAN	Increases Expression	[7]
Transcription factor HES-1 (HES1)	OT8P19W2	HES1_HUMAN	Decreases Expression	[7]
Nuclear factor interleukin-3-regulated protein (NFIL3)	OTQH9HM3	NFIL3_HUMAN	Increases Expression	[7]
Pre-rRNA-processing protein TSR1 homolog (TSR1)	OTCVZFL9	TSR1_HUMAN	Decreases Expression	[7]
Neurobeachin-like protein 2 (NBEAL2)	OTMCAXWR	NBEL2_HUMAN	Increases Expression	[7]
Protein FAM216A (FAM216A)	OTL6I6AI	F216A_HUMAN	Decreases Expression	[7]
Junctional adhesion molecule C (JAM3)	OTX0F9QL	JAM3_HUMAN	Increases Expression	[7]
Coiled-coil domain-containing protein 86 (CCDC86)	OT5YQ0R0	CCD86_HUMAN	Decreases Expression	[7]
Thiol S-methyltransferase TMT1A (TMT1A)	OT4IAAZP	TMT1A_HUMAN	Increases Expression	[7]
Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3)	OT8P6QNJ	CELR3_HUMAN	Decreases Expression	[7]
PALM2-AKAP2 fusion protein (PALM2AKAP2)	OTI618VF	PLAK2_HUMAN	Increases Expression	[7]
Nucleolar protein 16 (NOP16)	OT2829ZC	NOP16_HUMAN	Decreases Expression	[7]
Nucleolar complex protein 2 homolog (NOC2L)	OTNT7R33	NOC2L_HUMAN	Decreases Expression	[7]
Plexin-D1 (PLXND1)	OTNK9ALK	PLXD1_HUMAN	Increases Expression	[7]
Rho family-interacting cell polarization regulator 2 (RIPOR2)	OTXB6LIR	RIPR2_HUMAN	Increases Expression	[7]
Beta/gamma crystallin domain-containing protein 1 (CRYBG1)	OTIPDI15	CRBG1_HUMAN	Increases Expression	[7]
Trefoil factor 1 (TFF1)	OTCYQH4F	TFF1_HUMAN	Increases Expression	[37]
Serine/threonine-protein kinase Sgk1 (SGK1)	OT301T1U	SGK1_HUMAN	Increases Expression	[25]
Period circadian protein homolog 1 (PER1)	OTVQF3WX	PER1_HUMAN	Increases Expression	[25]
Macrophage colony-stimulating factor 1 receptor (CSF1R)	OTDYTB9C	CSF1R_HUMAN	Increases Expression	[25]
Amine oxidase A (MAOA)	OT8NIWMQ	AOFA_HUMAN	Increases Expression	[25]
Olfactomedin-4 (OLFM4)	OTELHN9L	OLFM4_HUMAN	Increases Expression	[25]
Cytochrome P450 2C9 (CYP2C9)	OTGLBN29	CP2C9_HUMAN	Increases Expression	[38]
Cytochrome P450 2B6 (CYP2B6)	OTOYO4S7	CP2B6_HUMAN	Increases Expression	[38]
Cytochrome P450 2C8 (CYP2C8)	OTHCWT42	CP2C8_HUMAN	Increases Expression	[39]
Nuclear receptor subfamily 1 group I member 3 (NR1I3)	OTS3SGH7	NR1I3_HUMAN	Increases Expression	[40]
Estrogen receptor (ESR1)	OTKLU61J	ESR1_HUMAN	Decreases Expression	[41]
Pulmonary surfactant-associated protein B (SFTPB)	OTOHS07E	PSPB_HUMAN	Increases Expression	[42]
Pulmonary surfactant-associated protein A1 (SFTPA1)	OT87XL1U	SFTA1_HUMAN	Decreases Expression	[42]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Decreases Expression	[43]
Cytochrome P450 2A6 (CYP2A6)	OT52TWG3	CP2A6_HUMAN	Increases Expression	[44]
Hepatocyte nuclear factor 4-alpha (HNF4A)	OTY1TOAB	HNF4A_HUMAN	Increases Expression	[44]
Sterol 26-hydroxylase, mitochondrial (CYP27A1)	OT649C01	CP27A_HUMAN	Increases Expression	[45]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Increases Expression	[46]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Decreases Activity	[46]
Cytochrome P450 1A2 (CYP1A2)	OTLLBX48	CP1A2_HUMAN	Decreases Activity	[46]
Mineralocorticoid receptor (NR3C2)	OT0F2V2Z	MCR_HUMAN	Increases Expression	[46]
Retinoic acid receptor alpha (RARA)	OT192V9V	RARA_HUMAN	Increases Expression	[46]
COUP transcription factor 1 (NR2F1)	OTGWZWYL	COT1_HUMAN	Increases Expression	[46]
Tyrosine aminotransferase (TAT)	OT2CJ91O	ATTY_HUMAN	Increases Expression	[46]
Retinoic acid receptor RXR-alpha (RXRA)	OTP1TBDM	RXRA_HUMAN	Increases Expression	[46]
Nuclear receptor ROR-alpha (RORA)	OTGQT12P	RORA_HUMAN	Increases Expression	[46]
Nuclear receptor subfamily 2 group C member 2 (NR2C2)	OTDZWVOJ	NR2C2_HUMAN	Increases Expression	[46]
Histone deacetylase 4 (HDAC4)	OTQNGD32	HDAC4_HUMAN	Increases Expression	[46]
Nuclear factor NF-kappa-B p100 subunit (NFKB2)	OTS231V7	NFKB2_HUMAN	Increases Expression	[46]
Oxysterols receptor LXR-alpha (NR1H3)	OT54YZ9I	NR1H3_HUMAN	Increases Expression	[46]
Nuclear receptor subfamily 6 group A member 1 (NR6A1)	OTFZOOQ9	NR6A1_HUMAN	Increases Expression	[46]
Nuclear receptor coactivator 2 (NCOA2)	OTMQFPBB	NCOA2_HUMAN	Increases Expression	[46]
Nuclear receptor coactivator 1 (NCOA1)	OTLIUJQD	NCOA1_HUMAN	Increases Expression	[46]
Histone acetyltransferase KAT2B (KAT2B)	OTWQITWK	KAT2B_HUMAN	Increases Expression	[46]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)	OTHCDQ22	PRGC1_HUMAN	Increases Expression	[46]
Organic solute transporter subunit alpha (SLC51A)	OTDJRZ0P	OSTA_HUMAN	Affects Expression	[47]
Organic solute transporter subunit beta (SLC51B)	OT4WYPSR	OSTB_HUMAN	Increases Expression	[47]
Toll-like receptor 4 (TLR4)	OTP7ML3S	TLR4_HUMAN	Increases Expression	[9]
Aquaporin-7 (AQP7)	OTSOSZEE	AQP7_HUMAN	Increases Expression	[9]
Lipid transferase CIDEA (CIDEA)	OTDUTSOV	CIDEA_HUMAN	Increases Expression	[9]
Renin receptor (ATP6AP2)	OT0IABVV	RENR_HUMAN	Decreases Expression	[9]
Complement factor D (CFD)	OTLNRXB6	CFAD_HUMAN	Increases Expression	[9]
Angiotensinogen (AGT)	OTBZLYR3	ANGT_HUMAN	Increases Expression	[9]
Beta-nerve growth factor (NGF)	OTOLABJT	NGF_HUMAN	Decreases Expression	[9]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Decreases Expression	[9]
Retinol-binding protein 4 (RBP4)	OTL9RBH5	RET4_HUMAN	Increases Expression	[9]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Increases Expression	[9]
Thrombospondin-1 (THBS1)	OT0ECWK3	TSP1_HUMAN	Increases Expression	[9]
Osteopontin (SPP1)	OTJGC23Y	OSTP_HUMAN	Increases Expression	[9]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Increases Expression	[9]
Fatty acid-binding protein, adipocyte (FABP4)	OT3DKFOU	FABP4_HUMAN	Increases Expression	[9]
NAD(P)H dehydrogenase 1 (NQO1)	OTZGGIVK	NQO1_HUMAN	Increases Expression	[9]
Vascular endothelial growth factor receptor 1 (FLT1)	OTT0OGYS	VGFR1_HUMAN	Increases Expression	[9]
Interleukin-10 (IL10)	OTIRFRXC	IL10_HUMAN	Decreases Expression	[9]
Glutathione peroxidase 3 (GPX3)	OT6PK94R	GPX3_HUMAN	Increases Expression	[9]
Zinc-alpha-2-glycoprotein (AZGP1)	OTPD9TDR	ZA2G_HUMAN	Increases Expression	[9]
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)	OTO7FJA9	DHI1_HUMAN	Increases Expression	[9]
Nitric oxide synthase 3 (NOS3)	OTLDT7NR	NOS3_HUMAN	Increases Expression	[9]
Pro-adrenomedullin (ADM)	OT7T0TA4	ADML_HUMAN	Increases Expression	[9]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Decreases Expression	[9]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Increases Expression	[9]
Phosphatidate phosphatase LPIN1 (LPIN1)	OTQ75KF2	LPIN1_HUMAN	Increases Expression	[9]
Adiponectin (ADIPOQ)	OTNX23LE	ADIPO_HUMAN	Increases Expression	[9]
Lipid transferase CIDEC (CIDEC)	OTMDZ56K	CIDEC_HUMAN	Increases Expression	[9]
NAD-dependent protein deacetylase sirtuin-1 (SIRT1)	OTAYZMOY	SIR1_HUMAN	Increases Expression	[9]
Histone-lysine N-methyltransferase PRDM16 (PRDM16)	OT0BGA27	PRD16_HUMAN	Decreases Expression	[9]
Apelin (APLN)	OTSWJD7B	APEL_HUMAN	Decreases Expression	[9]
Hepatic sodium/bile acid cotransporter (SLC10A1)	OTUJVMCL	NTCP_HUMAN	Increases Expression	[48]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Increases Expression	[49]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Increases Expression	[49]
Cytochrome P450 2S1 (CYP2S1)	OTKHX4RF	CP2S1_HUMAN	Decreases Expression	[50]
S-adenosylmethionine synthase isoform type-2 (MAT2A)	OTFJMIQR	METK2_HUMAN	Increases Expression	[51]
Glutathione reductase, mitochondrial (GSR)	OTM2TUYM	GSHR_HUMAN	Increases Expression	[52]
Metallothionein-2 (MT2A)	OTHOACHD	MT2_HUMAN	Increases Expression	[53]
Glucoside xylosyltransferase 2 (GXYLT2)	OTMLQQKP	GXLT2_HUMAN	Decreases Expression	[10]
Tetraspanin-11 (TSPAN11)	OT3GJF1N	TSN11_HUMAN	Decreases Expression	[10]
Glutamate-rich protein 2 (ERICH2)	OT0QA5Z1	ERIC2_HUMAN	Decreases Expression	[10]
Pleckstrin homology domain-containing family G member 3 (PLEKHG3)	OTF6I8RV	PKHG3_HUMAN	Increases Expression	[10]
Coiled-coil domain-containing protein 69 (CCDC69)	OT43MI0R	CCD69_HUMAN	Increases Expression	[10]
Very-long-chain (HACD1)	OTEC7EP7	HACD1_HUMAN	Increases Expression	[10]
Isthmin-1 (ISM1)	OTZTK2TV	ISM1_HUMAN	Increases Expression	[10]
Transmembrane protein 233 (TMEM233)	OT9J7BRF	TM233_HUMAN	Decreases Expression	[10]
PDZ and LIM domain protein 1 (PDLIM1)	OT4EGCPG	PDLI1_HUMAN	Increases Expression	[10]
Agrin (AGRN)	OTWJENAZ	AGRIN_HUMAN	Decreases Expression	[10]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2)	OTKOZRZP	PLOD2_HUMAN	Decreases Expression	[10]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PIK3C2B)	OTY2PROB	P3C2B_HUMAN	Increases Expression	[10]
Acetyl-CoA carboxylase 2 (ACACB)	OT96UIP1	ACACB_HUMAN	Increases Expression	[10]
Dihydropyrimidinase-related protein 4 (DPYSL4)	OT3SBS2S	DPYL4_HUMAN	Decreases Expression	[10]
Cdc42 effector protein 2 (CDC42EP2)	OTX3YDPN	BORG1_HUMAN	Increases Expression	[10]
Glutathione S-transferase 3, mitochondrial (MGST3)	OTYK80JA	MGST3_HUMAN	Increases Expression	[10]
Calmegin (CLGN)	OTEWVFQV	CLGN_HUMAN	Decreases Expression	[10]
Microtubule-associated serine/threonine-protein kinase 4 (MAST4)	OT3LOE2J	MAST4_HUMAN	Increases Expression	[10]
Synaptojanin-2 (SYNJ2)	OTLRHXP1	SYNJ2_HUMAN	Decreases Expression	[10]
Serine/threonine-protein kinase DCLK1 (DCLK1)	OTVSPS98	DCLK1_HUMAN	Increases Expression	[10]
Mothers against decapentaplegic homolog 7 (SMAD7)	OTSLHWF4	SMAD7_HUMAN	Decreases Expression	[10]
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)	OT5I4Y9K	PLCB_HUMAN	Increases Expression	[10]
Low-density lipoprotein receptor class A domain-containing protein 4 (LDLRAD4)	OTQUX50Z	LRAD4_HUMAN	Decreases Expression	[10]
Membrane-associated progesterone receptor component 2 (PGRMC2)	OTH6G1CV	PGRC2_HUMAN	Increases Expression	[10]
Protein SLC31A2 (SLC31A2)	OTQC136Q	COPT2_HUMAN	Decreases Expression	[10]
Prolyl 4-hydroxylase subunit alpha-2 (P4HA2)	OTP45YKX	P4HA2_HUMAN	Decreases Expression	[10]
Glycogenin-2 (GYG2)	OTAJ7YEW	GLYG2_HUMAN	Increases Expression	[10]
CASP8 and FADD-like apoptosis regulator (CFLAR)	OTX14BAS	CFLAR_HUMAN	Increases Expression	[10]
D-3-phosphoglycerate dehydrogenase (PHGDH)	OT1LMRTG	SERA_HUMAN	Decreases Expression	[10]
Rho GTPase-activating protein 6 (ARHGAP6)	OTNVXXFX	RHG06_HUMAN	Increases Expression	[10]
Cytohesin-3 (CYTH3)	OTBXAT3Z	CYH3_HUMAN	Increases Expression	[10]
Perilipin-1 (PLIN1)	OT3OAAZ4	PLIN1_HUMAN	Increases Expression	[10]
Acyl-CoA (FADS1)	OTUYOYHX	FADS1_HUMAN	Increases Expression	[10]
Protein-tyrosine sulfotransferase 1 (TPST1)	OTDPQKEA	TPST1_HUMAN	Decreases Expression	[10]
DNA polymerase zeta catalytic subunit (REV3L)	OT0OP8EJ	REV3L_HUMAN	Increases Expression	[10]
Sushi repeat-containing protein SRPX2 (SRPX2)	OT6A63TX	SRPX2_HUMAN	Increases Expression	[10]
Thiamine transporter 1 (SLC19A2)	OTH5SB0M	S19A2_HUMAN	Increases Expression	[10]
Receptor activity-modifying protein 1 (RAMP1)	OT7UT2XB	RAMP1_HUMAN	Increases Expression	[10]
Slit homolog 3 protein (SLIT3)	OTU8MKEU	SLIT3_HUMAN	Decreases Expression	[10]
Multiple epidermal growth factor-like domains protein 6 (MEGF6)	OTEUYTP1	MEGF6_HUMAN	Decreases Expression	[10]
Rho-associated protein kinase 2 (ROCK2)	OTVYN14T	ROCK2_HUMAN	Increases Expression	[10]
Cartilage intermediate layer protein 1 (CILP)	OTKEY2NJ	CILP1_HUMAN	Increases Expression	[10]
Citrate synthase, mitochondrial (CS)	OTYLYXMO	CISY_HUMAN	Increases Expression	[10]
Sperm-associated antigen 7 (SPAG7)	OTSDFA2D	SPAG7_HUMAN	Decreases Expression	[10]
Claudin-11 (CLDN11)	OTNN6UTL	CLD11_HUMAN	Increases Expression	[10]
E3 ubiquitin-protein ligase MYCBP2 (MYCBP2)	OTHODA1F	MYCB2_HUMAN	Increases Expression	[10]
Protein phosphatase 1B (PPM1B)	OTZMH6V3	PPM1B_HUMAN	Increases Expression	[10]
Cytosolic 10-formyltetrahydrofolate dehydrogenase (ALDH1L1)	OT15HOJX	AL1L1_HUMAN	Increases Expression	[10]
Diacylglycerol O-acyltransferase 1 (DGAT1)	OTL104WL	DGAT1_HUMAN	Increases Expression	[10]
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH1)	OT1U2GWG	DDAH1_HUMAN	Increases Expression	[10]
Serine/threonine-protein kinase 17B (STK17B)	OT4NYNO8	ST17B_HUMAN	Increases Expression	[10]
Slit homolog 2 protein (SLIT2)	OTLS2RJ4	SLIT2_HUMAN	Decreases Expression	[10]
Indolethylamine N-methyltransferase (INMT)	OT5NWOZH	INMT_HUMAN	Increases Expression	[10]
Neurexophilin-4 (NXPH4)	OTV057AG	NXPH4_HUMAN	Decreases Expression	[10]
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B)	OT4217NK	PDE8B_HUMAN	Increases Expression	[10]
CUGBP Elav-like family member 2 (CELF2)	OTLJJ4VT	CELF2_HUMAN	Increases Expression	[10]
Tumor necrosis factor alpha-induced protein 8 (TNFAIP8)	OT1G9297	TFIP8_HUMAN	Increases Expression	[10]
Angiopoietin-related protein 1 (ANGPTL1)	OTXIN6V5	ANGL1_HUMAN	Increases Expression	[10]
Zinc finger protein SNAI1 (SNAI1)	OTDPYAMC	SNAI1_HUMAN	Decreases Expression	[10]
Cholesterol 25-hydroxylase (CH25H)	OT9S2BSW	CH25H_HUMAN	Decreases Expression	[10]
Cytochrome b5 (CYB5A)	OT6SN4RM	CYB5_HUMAN	Increases Expression	[10]
All-trans-retinol dehydrogenase ADH1B (ADH1B)	OTV3TB81	ADH1B_HUMAN	Increases Expression	[10]
Alcohol dehydrogenase 1C (ADH1C)	OTO1DV7F	ADH1G_HUMAN	Increases Expression	[10]
Haptoglobin-related protein (HPR)	OTXSC9UB	HPTR_HUMAN	Increases Expression	[10]
Urokinase-type plasminogen activator (PLAU)	OTX0QGKK	UROK_HUMAN	Decreases Expression	[10]
Tissue-type plasminogen activator (PLAT)	OTQPDNAB	TPA_HUMAN	Decreases Expression	[10]
Carbonic anhydrase 2 (CA2)	OTJRMUAG	CAH2_HUMAN	Increases Expression	[10]
Argininosuccinate synthase (ASS1)	OT4ZMG0Q	ASSY_HUMAN	Increases Expression	[10]
Alpha-2-macroglobulin (A2M)	OTFTX90K	A2MG_HUMAN	Increases Expression	[10]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Increases Expression	[10]
Collagen alpha-1(III) chain (COL3A1)	OTT1EMLM	CO3A1_HUMAN	Decreases Expression	[10]
Collagen alpha-1(IV) chain (COL4A1)	OTL6D1YE	CO4A1_HUMAN	Increases Expression	[10]
Apolipoprotein E (APOE)	OTFOWL2H	APOE_HUMAN	Increases Expression	[10]
Myelin basic protein (MBP)	OTFZCEDB	MBP_HUMAN	Increases Expression	[10]
Interstitial collagenase (MMP1)	OTI4I2V1	MMP1_HUMAN	Decreases Expression	[10]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Increases Expression	[10]
HLA class I histocompatibility antigen, A alpha chain (HLA-A)	OTAH14LU	HLAA_HUMAN	Decreases Expression	[10]
Metallothionein-1A (MT1A)	OTKBH52X	MT1A_HUMAN	Increases Expression	[10]
Fatty acid-binding protein, heart (FABP3)	OT562DA1	FABPH_HUMAN	Increases Expression	[10]
Tetranectin (CLEC3B)	OTFD29NF	TETN_HUMAN	Increases Expression	[10]
Collagen alpha-2(V) chain (COL5A2)	OT5VOSQE	CO5A2_HUMAN	Decreases Expression	[10]
Gelsolin (GSN)	OT4KS2UU	GELS_HUMAN	Increases Expression	[10]
Glycogen phosphorylase, liver form (PYGL)	OTS1YFGR	PYGL_HUMAN	Increases Expression	[10]
Lipoprotein lipase (LPL)	OTTW0267	LIPL_HUMAN	Increases Expression	[10]
Glia-derived nexin (SERPINE2)	OTYF5340	GDN_HUMAN	Decreases Expression	[10]
Acyl-CoA-binding protein (DBI)	OT884QY9	ACBP_HUMAN	Increases Expression	[10]
L-lactate dehydrogenase B chain (LDHB)	OT9B1CT3	LDHB_HUMAN	Increases Expression	[10]
Neurofilament light polypeptide (NEFL)	OTQESJV4	NFL_HUMAN	Increases Expression	[10]
Alcohol dehydrogenase 1A (ADH1A)	OTTS983E	ADH1A_HUMAN	Increases Expression	[10]
Cathepsin D (CTSD)	OTQZ36F3	CATD_HUMAN	Decreases Expression	[10]
Metallothionein-1B (MT1B)	OTUA4FFH	MT1B_HUMAN	Increases Expression	[10]
Decorin (DCN)	OTWLJL7K	PGS2_HUMAN	Increases Expression	[10]
Insulin-like growth factor 1 receptor (IGF1R)	OTXJIF13	IGF1R_HUMAN	Decreases Expression	[10]
Collagen alpha-2(I) chain (COL1A2)	OTY7G382	CO1A2_HUMAN	Decreases Expression	[10]
Annexin A6 (ANXA6)	OT9KIQ0Y	ANXA6_HUMAN	Increases Expression	[10]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Decreases Expression	[10]
Asparagine synthetase (ASNS)	OT8R922G	ASNS_HUMAN	Decreases Expression	[10]
Stromelysin-1 (MMP3)	OTGBI74Z	MMP3_HUMAN	Decreases Expression	[10]
Inhibin beta A chain (INHBA)	OTSP64PQ	INHBA_HUMAN	Decreases Expression	[10]
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1)	OTGEU8IK	ODPA_HUMAN	Increases Expression	[10]
Matrilysin (MMP7)	OTVT3SEJ	MMP7_HUMAN	Increases Expression	[10]
Tropomyosin alpha-1 chain (TPM1)	OTD73X6R	TPM1_HUMAN	Decreases Expression	[10]
Annexin A4 (ANXA4)	OTUCRYXL	ANXA4_HUMAN	Increases Expression	[10]
Inhibin beta B chain (INHBB)	OT2QLD11	INHBB_HUMAN	Increases Expression	[10]
Interferon alpha-inducible protein 6 (IFI6)	OTWOOAM4	IFI6_HUMAN	Increases Expression	[10]
Protein ELFN1 (ELFN1)	OTM7M52U	ELFN1_HUMAN	Decreases Expression	[10]
Serum amyloid A-1 protein (SAA1)	OTO2D8S0	SAA1_HUMAN	Increases Expression	[10]
Zinc finger protein GLI2 (GLI2)	OTIRV97L	GLI2_HUMAN	Decreases Expression	[10]
HLA class I histocompatibility antigen, C alpha chain (HLA-C)	OTV38BUJ	HLAC_HUMAN	Decreases Expression	[10]
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (DLAT)	OT9LBJVN	ODP2_HUMAN	Increases Expression	[10]
Microsomal glutathione S-transferase 1 (MGST1)	OTGN1KVZ	MGST1_HUMAN	Increases Expression	[10]
Tissue factor pathway inhibitor (TFPI)	OTA0FX16	TFPI1_HUMAN	Increases Expression	[10]
Clusterin (CLU)	OTQGG0JM	CLUS_HUMAN	Decreases Expression	[10]
E3 SUMO-protein ligase EGR2 (EGR2)	OTAVQ78J	EGR2_HUMAN	Decreases Expression	[10]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Decreases Expression	[10]
Collagen alpha-2(VI) chain (COL6A2)	OTQC6PPO	CO6A2_HUMAN	Decreases Expression	[10]
Collagen alpha-3(VI) chain (COL6A3)	OTAS6R6I	CO6A3_HUMAN	Decreases Expression	[10]
Nidogen-1 (NID1)	OTKLBLS6	NID1_HUMAN	Increases Expression	[10]
Phospholipase A2, membrane associated (PLA2G2A)	OT1NY7BF	PA2GA_HUMAN	Increases Expression	[10]
Myosin light chain 6B (MYL6B)	OTWTRGT7	MYL6B_HUMAN	Decreases Expression	[10]
Matrix metalloproteinase-9 (MMP9)	OTB2QDAV	MMP9_HUMAN	Decreases Expression	[10]
Leukemia inhibitory factor (LIF)	OTO46S5S	LIF_HUMAN	Decreases Expression	[10]
Glutamine synthetase (GLUL)	OTYGTCGF	GLNA_HUMAN	Increases Expression	[10]
Beta-1,4-galactosyltransferase 1 (B4GALT1)	OTBCXEK7	B4GT1_HUMAN	Decreases Expression	[10]
Atrial natriuretic peptide receptor 1 (NPR1)	OTRWART5	ANPRA_HUMAN	Increases Expression	[10]
Platelet glycoprotein 4 (CD36)	OT5CZWKY	CD36_HUMAN	Increases Expression	[10]
Rho-related GTP-binding protein RhoQ (RHOQ)	OTUBTU57	RHOQ_HUMAN	Increases Expression	[10]
Endoglin (ENG)	OTL2LSMI	EGLN_HUMAN	Decreases Expression	[10]
Insulin-like growth factor-binding protein 3 (IGFBP3)	OTIX63TX	IBP3_HUMAN	Decreases Expression	[10]
Insulin-like growth factor-binding protein 2 (IGFBP2)	OTG1P60E	IBP2_HUMAN	Increases Expression	[10]
Alpha-2C adrenergic receptor (ADRA2C)	OT5B9RKP	ADA2C_HUMAN	Increases Expression	[10]
Cadherin-2 (CDH2)	OTH0Y56P	CADH2_HUMAN	Decreases Expression	[10]
C-X-C motif chemokine 2 (CXCL2)	OTEJCYMY	CXCL2_HUMAN	Decreases Expression	[10]
C-X-C motif chemokine 3 (CXCL3)	OTSL94KH	CXCL3_HUMAN	Decreases Expression	[10]
Interferon-induced GTP-binding protein Mx2 (MX2)	OT05NF37	MX2_HUMAN	Increases Expression	[10]
B-cell lymphoma 3 protein (BCL3)	OT1M5B95	BCL3_HUMAN	Decreases Expression	[10]
Interleukin-11 (IL11)	OTXHN86R	IL11_HUMAN	Decreases Expression	[10]
Collagen alpha-1(V) chain (COL5A1)	OT24078H	CO5A1_HUMAN	Decreases Expression	[10]
Cytoplasmic aconitate hydratase (ACO1)	OT2VUR7L	ACOHC_HUMAN	Increases Expression	[10]
Cannabinoid receptor 1 (CNR1)	OTEALO6G	CNR1_HUMAN	Increases Expression	[10]
Glycerol-3-phosphate dehydrogenase , cytoplasmic (GPD1)	OTQW7TMB	GPDA_HUMAN	Increases Expression	[10]
Midkine (MDK)	OTF24HKC	MK_HUMAN	Decreases Expression	[10]
Biglycan (BGN)	OT3AV6IF	PGS1_HUMAN	Decreases Expression	[10]
Liver carboxylesterase 1 (CES1)	OT9L0LR8	EST1_HUMAN	Increases Expression	[10]
Prostaglandin G/H synthase 1 (PTGS1)	OTHCRLEC	PGH1_HUMAN	Increases Expression	[10]
Receptor-type tyrosine-protein phosphatase gamma (PTPRG)	OT9N2WOF	PTPRG_HUMAN	Increases Expression	[10]
Brain-derived neurotrophic factor (BDNF)	OTLGH7EW	BDNF_HUMAN	Decreases Expression	[10]
Plasma membrane calcium-transporting ATPase 4 (ATP2B4)	OTMWFDAC	AT2B4_HUMAN	Increases Expression	[10]
Cytochrome c oxidase subunit 7A1, mitochondrial (COX7A1)	OTHV25GG	CX7A1_HUMAN	Increases Expression	[10]
Interleukin-4 receptor subunit alpha (IL4R)	OTTXOTCW	IL4RA_HUMAN	Decreases Expression	[10]
Insulin-like growth factor-binding protein 5 (IGFBP5)	OTRE5V0C	IBP5_HUMAN	Increases Expression	[10]
ATP synthase subunit alpha, mitochondrial (ATP5F1A)	OT3FZDLX	ATPA_HUMAN	Increases Expression	[10]
Metallothionein-3 (MT3)	OTVCZ7HI	MT3_HUMAN	Increases Expression	[10]
Protein S100-A4 (S100A4)	OTLRGFSQ	S10A4_HUMAN	Increases Expression	[10]
Stomatin (STOM)	OTC8R6EH	STOM_HUMAN	Increases Expression	[10]
G0/G1 switch protein 2 (G0S2)	OT8FL49L	G0S2_HUMAN	Increases Expression	[10]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)	OT5BZ1J9	P85A_HUMAN	Increases Expression	[10]
Leiomodin-1 (LMOD1)	OTZ2MEMG	LMOD1_HUMAN	Increases Expression	[10]
Myristoylated alanine-rich C-kinase substrate (MARCKS)	OT7N056G	MARCS_HUMAN	Decreases Expression	[10]
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (ALDH4A1)	OT25Z6XH	AL4A1_HUMAN	Increases Expression	[10]
Peroxiredoxin-6 (PRDX6)	OTS8KC8A	PRDX6_HUMAN	Increases Expression	[10]
cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B)	OTZEXEFH	KAP3_HUMAN	Increases Expression	[10]
Transcription factor HIVEP2 (HIVEP2)	OTVOMCW4	ZEP2_HUMAN	Decreases Expression	[10]
Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1)	OTQHB52T	P5CR1_HUMAN	Decreases Expression	[10]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1)	OTB06ESI	ACSL1_HUMAN	Increases Expression	[10]
Lymphocyte-specific protein 1 (LSP1)	OTSPSIFO	LSP1_HUMAN	Decreases Expression	[10]
Serine hydroxymethyltransferase, mitochondrial (SHMT2)	OT5NCAZN	GLYM_HUMAN	Decreases Expression	[10]
G protein-coupled receptor kinase 5 (GRK5)	OTJK79EK	GRK5_HUMAN	Increases Expression	[10]
Thrombospondin-2 (THBS2)	OTXET551	TSP2_HUMAN	Decreases Expression	[10]
Fibrillin-2 (FBN2)	OT3KYJQL	FBN2_HUMAN	Increases Expression	[10]
Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)	OTNWEJ5Y	PCKGC_HUMAN	Increases Expression	[10]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Decreases Expression	[10]
Sterol regulatory element-binding protein 1 (SREBF1)	OTWBRPAI	SRBP1_HUMAN	Increases Expression	[10]
Serine/threonine-protein kinase receptor R3 (ACVRL1)	OT1HQR88	ACVL1_HUMAN	Increases Expression	[10]
Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA)	OTIOLNHE	LICH_HUMAN	Increases Expression	[10]
Collagen alpha-1(XV) chain (COL15A1)	OTTFKK18	COFA1_HUMAN	Decreases Expression	[10]
Malate dehydrogenase, cytoplasmic (MDH1)	OTJEO4E8	MDHC_HUMAN	Increases Expression	[10]
DNA-binding protein inhibitor ID-1 (ID1)	OTKGNZN5	ID1_HUMAN	Decreases Expression	[10]
Mitogen-activated protein kinase kinase kinase 8 (MAP3K8)	OTOZTA1F	M3K8_HUMAN	Increases Expression	[10]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Increases Expression	[10]
Cyclin-dependent kinase 4 inhibitor C (CDKN2C)	OTCLOV90	CDN2C_HUMAN	Increases Expression	[10]
Excitatory amino acid transporter 1 (SLC1A3)	OTILR60R	EAA1_HUMAN	Decreases Expression	[10]
Prostaglandin F2-alpha receptor (PTGFR)	OTUI456H	PF2R_HUMAN	Decreases Expression	[10]
Prostaglandin E2 receptor EP3 subtype (PTGER3)	OTQODQUN	PE2R3_HUMAN	Increases Expression	[10]
Cathepsin K (CTSK)	OTT3YX5O	CATK_HUMAN	Increases Expression	[10]
Nicotinamide phosphoribosyltransferase (NAMPT)	OTVJR3GL	NAMPT_HUMAN	Decreases Expression	[10]
Aspartoacylase (ASPA)	OTR2MWS4	ACY2_HUMAN	Increases Expression	[10]
Large proline-rich protein BAG6 (BAG6)	OT4Z0S2U	BAG6_HUMAN	Decreases Expression	[10]
B1 bradykinin receptor (BDKRB1)	OT1DHSVQ	BKRB1_HUMAN	Decreases Expression	[10]
Radiation-inducible immediate-early gene IEX-1 (IER3)	OTZJI5FZ	IEX1_HUMAN	Decreases Expression	[10]
Retinaldehyde dehydrogenase 3 (ALDH1A3)	OT1C9NKQ	AL1A3_HUMAN	Increases Expression	[10]
Sodium- and chloride-dependent glycine transporter 1 (SLC6A9)	OTHRUON2	SC6A9_HUMAN	Decreases Expression	[10]
Tissue factor pathway inhibitor 2 (TFPI2)	OTZCRWOR	TFPI2_HUMAN	Decreases Expression	[10]
Fatty acid synthase (FASN)	OTFII9KG	FAS_HUMAN	Increases Expression	[10]
Amphiphysin (AMPH)	OTWPGWZX	AMPH_HUMAN	Increases Expression	[10]
Thrombospondin-3 (THBS3)	OTDKMUBD	TSP3_HUMAN	Decreases Expression	[10]
Placenta growth factor (PGF)	OT5MF5DJ	PLGF_HUMAN	Decreases Expression	[10]
Retinoic acid receptor responder protein 1 (RARRES1)	OTETUPP5	TIG1_HUMAN	Decreases Expression	[10]
Selenoprotein P (SELENOP)	OT02B8IR	SEPP1_HUMAN	Increases Expression	[10]
Max-interacting protein 1 (MXI1)	OTUQ9E0D	MXI1_HUMAN	Decreases Expression	[10]
RNA-binding protein Nova-1 (NOVA1)	OT6A9KHY	NOVA1_HUMAN	Increases Expression	[10]
Caveolin-2 (CAV2)	OT1FGRQX	CAV2_HUMAN	Increases Expression	[10]
Glypican-3 (GPC3)	OTWS8WSW	GPC3_HUMAN	Increases Expression	[10]
Lumican (LUM)	OTSRC874	LUM_HUMAN	Decreases Expression	[10]
Tricarboxylate transport protein, mitochondrial (SLC25A1)	OTIDXQ9F	TXTP_HUMAN	Increases Expression	[10]
Protein FosB (FOSB)	OTW6C05J	FOSB_HUMAN	Increases Expression	[10]
Sodium/myo-inositol cotransporter (SLC5A3)	OT6FY2KA	SC5A3_HUMAN	Decreases Expression	[10]
Phospholipase A and acyltransferase 3 (PLAAT3)	OTVXXJ5K	PLAT3_HUMAN	Increases Expression	[10]
Heat shock-related 70 kDa protein 2 (HSPA2)	OTSDET7B	HSP72_HUMAN	Increases Expression	[10]
Sodium/potassium-transporting ATPase subunit beta-3 (ATP1B3)	OTOFL24U	AT1B3_HUMAN	Increases Expression	[10]
Epithelial membrane protein 1 (EMP1)	OTSZHUHQ	EMP1_HUMAN	Increases Expression	[10]
Microfibrillar-associated protein 2 (MFAP2)	OTMHVBTV	MFAP2_HUMAN	Decreases Expression	[10]
GTP-binding protein GEM (GEM)	OT6SK8ZV	GEM_HUMAN	Decreases Expression	[10]
Growth/differentiation factor 10 (GDF10)	OTEVXGJ7	GDF10_HUMAN	Decreases Expression	[10]
Laminin subunit beta-2 (LAMB2)	OT71OI2Y	LAMB2_HUMAN	Decreases Expression	[10]
GDNF family receptor alpha-1 (GFRA1)	OT3WBVYB	GFRA1_HUMAN	Increases Expression	[10]
Homeobox protein DLX-5 (DLX5)	OTEEFBEU	DLX5_HUMAN	Decreases Expression	[10]
Junctional adhesion molecule B (JAM2)	OTHVJJRJ	JAM2_HUMAN	Decreases Expression	[10]
Lysyl oxidase homolog 3 (LOXL3)	OTLLY1QI	LOXL3_HUMAN	Decreases Expression	[10]
Protein eva-1 homolog C (EVA1C)	OT18YR25	EVA1C_HUMAN	Increases Expression	[10]
Reactive oxygen species modulator 1 (ROMO1)	OTIEYVBW	ROMO1_HUMAN	Increases Expression	[10]
Ras-related protein Rab-2A (RAB2A)	OT6SK83U	RAB2A_HUMAN	Increases Expression	[10]
Somatostatin (SST)	OTY75GQH	SMS_HUMAN	Decreases Expression	[10]
Ras-related protein R-Ras2 (RRAS2)	OT83NCEB	RRAS2_HUMAN	Increases Expression	[10]
Thymosin beta-4 (TMSB4X)	OT9HPLP3	TYB4_HUMAN	Increases Expression	[10]
Histone H4 (H4C1)	OTB71W46	H4_HUMAN	Decreases Expression	[10]
DNA-directed RNA polymerases I, II, and III subunit RPABC5 (POLR2L)	OTSSOMUP	RPAB5_HUMAN	Increases Expression	[10]
Gamma-aminobutyric acid receptor subunit epsilon (GABRE)	OTXF5ICU	GBRE_HUMAN	Decreases Expression	[10]
Sushi repeat-containing protein SRPX (SRPX)	OT5B9LXS	SRPX_HUMAN	Increases Expression	[10]
C-X-C motif chemokine 6 (CXCL6)	OTFTCQ4O	CXCL6_HUMAN	Decreases Expression	[10]
Metallothionein-1H (MT1H)	OT0MVBM6	MT1H_HUMAN	Increases Expression	[10]
Metallothionein-1X (MT1X)	OT9AKFVS	MT1X_HUMAN	Increases Expression	[10]
Nucleobindin-2 (NUCB2)	OTHO6JWN	NUCB2_HUMAN	Decreases Expression	[10]
4-aminobutyrate aminotransferase, mitochondrial (ABAT)	OTXAGR7J	GABT_HUMAN	Increases Expression	[10]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)	OT1SLUZH	TSG6_HUMAN	Decreases Expression	[10]
Spectrin beta chain, non-erythrocytic 1 (SPTBN1)	OTOVM4D4	SPTB2_HUMAN	Increases Expression	[10]
Peripheral myelin protein 22 (PMP22)	OTXWYWCZ	PMP22_HUMAN	Increases Expression	[10]
Fatty acid-binding protein 5 (FABP5)	OTNM186C	FABP5_HUMAN	Increases Expression	[10]
Large neutral amino acids transporter small subunit 1 (SLC7A5)	OT2WPVXD	LAT1_HUMAN	Decreases Expression	[10]
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)	OTEUYEW6	ROR1_HUMAN	Increases Expression	[10]
D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH1)	OT62RL5P	BDH_HUMAN	Increases Expression	[10]
Collagen alpha-1(VII) chain (COL7A1)	OT3MIRZJ	CO7A1_HUMAN	Decreases Expression	[10]
DNA-binding protein inhibitor ID-3 (ID3)	OTUULW5Z	ID3_HUMAN	Decreases Expression	[10]
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (GCNT1)	OTF6OC66	GCNT1_HUMAN	Increases Expression	[10]
Caveolin-1 (CAV1)	OTEZUR1L	CAV1_HUMAN	Increases Expression	[10]
Transforming growth factor beta receptor type 3 (TGFBR3)	OTQOOUC4	TGBR3_HUMAN	Increases Expression	[10]
Peroxisome proliferator-activated receptor delta (PPARD)	OTI4WTOP	PPARD_HUMAN	Decreases Expression	[10]
Mevalonate kinase (MVK)	OTHJCUKT	KIME_HUMAN	Increases Expression	[10]
1,4-alpha-glucan-branching enzyme (GBE1)	OTK2N05B	GLGB_HUMAN	Increases Expression	[10]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Increases Expression	[10]
Hormone-sensitive lipase (LIPE)	OTMMVJ8A	LIPS_HUMAN	Increases Expression	[10]
Collagen alpha-1(XIV) chain (COL14A1)	OTLNJ13O	COEA1_HUMAN	Decreases Expression	[10]
Aldehyde oxidase (AOX1)	OT2FZP6H	AOXA_HUMAN	Increases Expression	[10]
Prolow-density lipoprotein receptor-related protein 1 (LRP1)	OTHTEH4G	LRP1_HUMAN	Decreases Expression	[10]
Nexilin (NEXN)	OTKB0B0H	NEXN_HUMAN	Increases Expression	[10]
Forkhead box protein O1 (FOXO1)	OTPJRB6D	FOXO1_HUMAN	Increases Expression	[10]
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1)	OTZVUOOB	FBLN3_HUMAN	Decreases Expression	[10]
Trophinin (TRO)	OTRZQMU8	TROP_HUMAN	Decreases Expression	[10]
Epidermal growth factor receptor kinase substrate 8 (EPS8)	OTZ6ES6V	EPS8_HUMAN	Increases Expression	[10]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)	OT4SO7J4	BNIP3_HUMAN	Decreases Expression	[10]
Pappalysin-1 (PAPPA)	OTTTG9PG	PAPP1_HUMAN	Decreases Expression	[10]
Methanethiol oxidase (SELENBP1)	OT3NZNTR	SBP1_HUMAN	Increases Expression	[10]
Beta-2-syntrophin (SNTB2)	OTIVMQ2S	SNTB2_HUMAN	Increases Expression	[10]
Protein phosphatase 1 regulatory subunit 1A (PPP1R1A)	OTGTAGCV	PPR1A_HUMAN	Increases Expression	[10]
Cullin-4B (CUL4B)	OT2QX4DO	CUL4B_HUMAN	Increases Expression	[10]
Integrin alpha-7 (ITGA7)	OTTBTAYW	ITA7_HUMAN	Increases Expression	[10]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)	OTGM06VJ	IDI1_HUMAN	Increases Expression	[10]
Runt-related transcription factor 2 (RUNX2)	OT97RQQM	RUNX2_HUMAN	Decreases Expression	[10]
Protein Tob2 (TOB2)	OTEEHL60	TOB2_HUMAN	Increases Expression	[10]
Four and a half LIM domains protein 2 (FHL2)	OT0OAYWT	FHL2_HUMAN	Decreases Expression	[10]
Dihydropyrimidinase-related protein 3 (DPYSL3)	OTINJV20	DPYL3_HUMAN	Decreases Expression	[10]
Frizzled-2 (FZD2)	OT952ML1	FZD2_HUMAN	Decreases Expression	[10]
Transforming growth factor beta activator LRRC32 (LRRC32)	OTG7EDZL	LRC32_HUMAN	Decreases Expression	[10]
Squalene monooxygenase (SQLE)	OT0GGRDO	ERG1_HUMAN	Increases Expression	[10]
KN motif and ankyrin repeat domain-containing protein 1 (KANK1)	OT2E7A6W	KANK1_HUMAN	Increases Expression	[10]
Neutral alpha-glucosidase AB (GANAB)	OTYLXY4M	GANAB_HUMAN	Decreases Expression	[10]
Potassium voltage-gated channel subfamily B member 1 (KCNB1)	OTLCU4FR	KCNB1_HUMAN	Increases Expression	[10]
Delta(14)-sterol reductase LBR (LBR)	OT1HG3HG	LBR_HUMAN	Increases Expression	[10]
Latent-transforming growth factor beta-binding protein 2 (LTBP2)	OTS88GSD	LTBP2_HUMAN	Decreases Expression	[10]
Periostin (POSTN)	OTWP62UA	POSTN_HUMAN	Decreases Expression	[10]
Platelet-activating factor acetylhydrolase IB subunit alpha1 (PAFAH1B3)	OT6A9JT8	PA1B3_HUMAN	Decreases Expression	[10]
Inorganic pyrophosphatase (PPA1)	OTHZK1QB	IPYR_HUMAN	Increases Expression	[10]
Platelet-derived growth factor receptor-like protein (PDGFRL)	OTJPRECT	PGFRL_HUMAN	Decreases Expression	[10]
Delta(24)-sterol reductase (DHCR24)	OTP301JW	DHC24_HUMAN	Increases Expression	[10]
Transforming growth factor-beta-induced protein ig-h3 (TGFBI)	OTR443C5	BGH3_HUMAN	Decreases Expression	[10]
2'-5'-oligoadenylate synthase-like protein (OASL)	OTZ05YRP	OASL_HUMAN	Increases Expression	[10]
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL)	OTK3EJFD	NSDHL_HUMAN	Increases Expression	[10]
NGFI-A-binding protein 2 (NAB2)	OTG4BDF3	NAB2_HUMAN	Decreases Expression	[10]
Ovarian cancer G-protein coupled receptor 1 (GPR68)	OT1NXSMN	OGR1_HUMAN	Decreases Expression	[10]
Myosin light chain kinase, smooth muscle (MYLK)	OT78QB4A	MYLK_HUMAN	Increases Expression	[10]
Adipogenesis regulatory factor (ADIRF)	OTTJP8D4	ADIRF_HUMAN	Increases Expression	[10]
Neuronatin (NNAT)	OTNRLO7G	NNAT_HUMAN	Increases Expression	[10]
Neuronal regeneration-related protein (NREP)	OT2AZPKK	NREP_HUMAN	Decreases Expression	[10]
kinase isozyme 4, mitochondrial (PDK4)	OTCMHMBZ	PDK4_HUMAN	Increases Expression	[10]
Hypoxia-inducible factor 1-alpha (HIF1A)	OTADSC03	HIF1A_HUMAN	Decreases Expression	[10]
Thiosulfate sulfurtransferase (TST)	OTZ4F5LK	THTR_HUMAN	Increases Expression	[10]
NADP-dependent malic enzyme, mitochondrial (ME3)	OT3XMLYG	MAON_HUMAN	Increases Expression	[10]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH)	OTJDOL20	HCDH_HUMAN	Increases Expression	[10]
Amine oxidase 3 (AOC3)	OT30YKV0	AOC3_HUMAN	Increases Expression	[10]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)	OTQYEXL2	F264_HUMAN	Decreases Expression	[10]
Cysteine dioxygenase type 1 (CDO1)	OTLG1P77	CDO1_HUMAN	Increases Expression	[10]
Transmembrane protein 132A (TMEM132A)	OTNUI7O1	T132A_HUMAN	Decreases Expression	[10]
Kinesin-like protein KIF26B (KIF26B)	OTVHWIKR	KI26B_HUMAN	Decreases Expression	[10]
Transmembrane protein 44 (TMEM44)	OTRUF467	TMM44_HUMAN	Decreases Expression	[10]
PWWP domain-containing DNA repair factor 3A (PWWP3A)	OTXQVL4U	PWP3A_HUMAN	Decreases Expression	[10]
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1)	OTOBICRD	SVEP1_HUMAN	Increases Expression	[10]
Fibronectin type III domain-containing protein 1 (FNDC1)	OTU2BA12	FNDC1_HUMAN	Decreases Expression	[10]
BolA-like protein 3 (BOLA3)	OTDEDY0S	BOLA3_HUMAN	Increases Expression	[10]
Cordon-bleu protein-like 1 (COBLL1)	OTQFN1TC	COBL1_HUMAN	Increases Expression	[10]
Mesoderm-specific transcript homolog protein (MEST)	OT8Q4U8Y	MEST_HUMAN	Increases Expression	[10]
Proline-rich transmembrane protein 3 (PRRT3)	OT231D18	PRRT3_HUMAN	Increases Expression	[10]
SH3 domain-containing protein 19 (SH3D19)	OTVU3VS2	SH319_HUMAN	Increases Expression	[10]
Dedicator of cytokinesis protein 11 (DOCK11)	OTFSTN6A	DOC11_HUMAN	Increases Expression	[10]
Long-chain fatty acid transport protein 3 (SLC27A3)	OTXB60L7	S27A3_HUMAN	Increases Expression	[10]
Transcription factor HIVEP3 (HIVEP3)	OTM3QT3L	ZEP3_HUMAN	Increases Expression	[10]
Transmembrane protein 170B (TMEM170B)	OT4AS8RJ	T170B_HUMAN	Increases Expression	[10]
Immediate early response gene 5-like protein (IER5L)	OT6IG629	IER5L_HUMAN	Decreases Expression	[10]
E3 ubiquitin-protein ligase RNF187 (RNF187)	OTXTN1HP	RN187_HUMAN	Decreases Expression	[10]
Collagen alpha-1(XIII) chain (COL13A1)	OTM9IM6J	CODA1_HUMAN	Decreases Expression	[10]
Opioid growth factor receptor-like protein 1 (OGFRL1)	OT6QGBYE	OGRL1_HUMAN	Increases Expression	[10]
Synaptophysin-like protein 2 (SYPL2)	OT6CV0CA	SYPL2_HUMAN	Increases Expression	[10]
Phospholipid phosphatase 4 (PLPP4)	OTH5EXZC	PLPP4_HUMAN	Decreases Expression	[10]
Pikachurin (EGFLAM)	OTACZZJ0	EGFLA_HUMAN	Increases Expression	[10]
Tensin-2 (TNS2)	OTP72P0F	TENS2_HUMAN	Increases Expression	[10]
Meteorin-like protein (METRNL)	OTB0DDL0	METRL_HUMAN	Decreases Expression	[10]
La-related protein 1B (LARP1B)	OT9JZ7K5	LAR1B_HUMAN	Increases Expression	[10]
Protein sel-1 homolog 3 (SEL1L3)	OT10N6Z2	SE1L3_HUMAN	Decreases Expression	[10]
Scavenger receptor class A member 3 (SCARA3)	OT46I38Y	SCAR3_HUMAN	Decreases Expression	[10]
Dermokine (DMKN)	OTRIGZMK	DMKN_HUMAN	Increases Expression	[10]
Protein Jade-1 (JADE1)	OTBPJIRI	JADE1_HUMAN	Increases Expression	[10]
All-trans-retinol 13,14-reductase (RETSAT)	OTC3AOPX	RETST_HUMAN	Increases Expression	[10]
Caveolae-associated protein 1 (CAVIN1)	OTFO915U	CAVN1_HUMAN	Increases Expression	[10]
Lysophospholipid acyltransferase 5 (LPCAT3)	OTWI96P4	MBOA5_HUMAN	Increases Expression	[10]
F-box only protein 42 (FBXO42)	OTHPN53C	FBX42_HUMAN	Decreases Expression	[10]
Connector enhancer of kinase suppressor of ras 3 (CNKSR3)	OTXP4QH8	CNKR3_HUMAN	Increases Expression	[10]
Dehydrogenase/reductase SDR family member 4-like 2 (DHRS4L2)	OTKH0NVX	DR4L2_HUMAN	Increases Expression	[10]
Ras-like protein family member 11A (RASL11A)	OTDO6CMY	RSLBA_HUMAN	Increases Expression	[10]
Kelch-like protein 17 (KLHL17)	OTUWIJIQ	KLH17_HUMAN	Decreases Expression	[10]
Golgi-associated kinase 1B (GASK1B)	OT2HPHEI	GAK1B_HUMAN	Increases Expression	[10]
Sushi domain-containing protein 1 (SUSD1)	OTR3UGLY	SUSD1_HUMAN	Increases Expression	[10]
Suprabasin (SBSN)	OT89RKJH	SBSN_HUMAN	Increases Expression	[10]
Plexin domain-containing protein 2 (PLXDC2)	OTS1FUV6	PXDC2_HUMAN	Decreases Expression	[10]
Inactive serine protease PAMR1 (PAMR1)	OT83ZH5U	PAMR1_HUMAN	Decreases Expression	[10]
Interleukin-20 receptor subunit beta (IL20RB)	OTHFXK95	I20RB_HUMAN	Decreases Expression	[10]
Very-long-chain (HACD2)	OTAZO9F6	HACD2_HUMAN	Increases Expression	[10]
Transmembrane protein 64 (TMEM64)	OTO9IDFD	TMM64_HUMAN	Increases Expression	[10]
Scavenger receptor class A member 5 (SCARA5)	OTOVA96E	SCAR5_HUMAN	Increases Expression	[10]
SPOC domain-containing protein 1 (SPOCD1)	OTF4K46N	SPOC1_HUMAN	Increases Expression	[10]
Nesprin-3 (SYNE3)	OTEOJBYB	SYNE3_HUMAN	Increases Expression	[10]
Zinc finger protein basonuclin-2 (BNC2)	OTU22H9Z	BNC2_HUMAN	Decreases Expression	[10]
DNA-binding protein RFX8 (RFX8)	OT27SFGQ	RFX8_HUMAN	Decreases Expression	[10]
TOM1-like protein 2 (TOM1L2)	OTUXXUH8	TM1L2_HUMAN	Increases Expression	[10]
Protein phosphatase Slingshot homolog 2 (SSH2)	OT8NCK82	SSH2_HUMAN	Increases Expression	[10]
Endonuclease/exonuclease/phosphatase family domain-containing protein 1 (EEPD1)	OTTOGO05	EEPD1_HUMAN	Increases Expression	[10]
Peroxiredoxin-like 2C (PRXL2C)	OTI8ZAK8	PXL2C_HUMAN	Increases Expression	[10]
Protein mono-ADP-ribosyltransferase TIPARP (TIPARP)	OTZ4BG4B	PARPT_HUMAN	Increases Expression	[10]
LIM and senescent cell antigen-like-containing domain protein 2 (LIMS2)	OTZ7IIPM	LIMS2_HUMAN	Increases Expression	[10]
L-xylulose reductase (DCXR)	OTYVXRXB	DCXR_HUMAN	Increases Expression	[10]
Rho GTPase-activating protein 22 (ARHGAP22)	OTXUQEFL	RHG22_HUMAN	Decreases Expression	[10]
PX domain-containing protein kinase-like protein (PXK)	OTSP1WLK	PXK_HUMAN	Decreases Expression	[10]
Disheveled-associated activator of morphogenesis 2 (DAAM2)	OTC1WVZT	DAAM2_HUMAN	Increases Expression	[10]
Acyl-coenzyme A thioesterase 1 (ACOT1)	OTXFL7WM	ACOT1_HUMAN	Increases Expression	[10]
Regulating synaptic membrane exocytosis protein 1 (RIMS1)	OT10T7CK	RIMS1_HUMAN	Increases Expression	[10]
Metalloprotease TIKI1 (TRABD2A)	OTVMA26J	TIKI1_HUMAN	Increases Expression	[10]
Liprin-beta-1 (PPFIBP1)	OTRA2S7B	LIPB1_HUMAN	Decreases Expression	[10]
Chondroitin sulfate synthase 1 (CHSY1)	OTB1XSSF	CHSS1_HUMAN	Decreases Expression	[10]
Extracellular matrix organizing protein FRAS1 (FRAS1)	OTLPESF3	FRAS1_HUMAN	Increases Expression	[10]
Beta-klotho (KLB)	OTTKKFS8	KLOTB_HUMAN	Increases Expression	[10]
Protein O-mannosyl-transferase TMTC1 (TMTC1)	OTZ7NW96	TMTC1_HUMAN	Increases Expression	[10]
5'-3' exonuclease PLD3 (PLD3)	OTL07SP2	PLD3_HUMAN	Decreases Expression	[10]
Sodium/hydrogen exchanger 9 (SLC9A9)	OT00PCW3	SL9A9_HUMAN	Increases Expression	[10]
Neuron navigator 3 (NAV3)	OT97M1TR	NAV3_HUMAN	Increases Expression	[10]
Prolyl 3-hydroxylase 2 (P3H2)	OTY84H6U	P3H2_HUMAN	Decreases Expression	[10]
DCN1-like protein 3 (DCUN1D3)	OTG20VWE	DCNL3_HUMAN	Increases Expression	[10]
Cullin-9 (CUL9)	OTPUCLZT	CUL9_HUMAN	Decreases Expression	[10]
Extracellular sulfatase Sulf-1 (SULF1)	OTJCNCO0	SULF1_HUMAN	Decreases Expression	[10]
CD302 antigen (CD302)	OTX580VU	CD302_HUMAN	Increases Expression	[10]
Trafficking regulator of GLUT4 1 (TRARG1)	OTQ1R3JD	TARG1_HUMAN	Increases Expression	[10]
Polypeptide N-acetylgalactosaminyltransferase 12 (GALNT12)	OTVIBUST	GLT12_HUMAN	Decreases Expression	[10]
Solute carrier family 22 member 15 (SLC22A15)	OT60WAAI	S22AF_HUMAN	Decreases Expression	[10]
Protein APCDD1 (APCDD1)	OTV9AD0L	APCD1_HUMAN	Increases Expression	[10]
Cell cycle exit and neuronal differentiation protein 1 (CEND1)	OTPHOC22	CEND_HUMAN	Increases Expression	[10]
ATP-binding cassette sub-family A member 6 (ABCA6)	OTJJELUF	ABCA6_HUMAN	Increases Expression	[10]
Glypican-2 (GPC2)	OT3WSQE1	GPC2_HUMAN	Decreases Expression	[10]
Protein odd-skipped-related 2 (OSR2)	OTYG371T	OSR2_HUMAN	Increases Expression	[10]
Protein FAM43A (FAM43A)	OT5RPQRE	FA43A_HUMAN	Increases Expression	[10]
Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1L)	OTVLWW9T	GPD1L_HUMAN	Increases Expression	[10]
Metallothionein-1M (MT1M)	OTVT8PLU	MT1M_HUMAN	Increases Expression	[10]
Maturin (MTURN)	OTEBJNVG	MTURN_HUMAN	Increases Expression	[10]
GTP-binding protein 8 (GTPBP8)	OTI8X03A	GTPB8_HUMAN	Increases Expression	[10]
Tetratricopeptide repeat protein 39C (TTC39C)	OTKKI81C	TT39C_HUMAN	Increases Expression	[10]
Refilin-B (RFLNB)	OTI7ZM75	RFLB_HUMAN	Decreases Expression	[10]
Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2)	OT2SH7HJ	CGAT2_HUMAN	Decreases Expression	[10]
Uncharacterized protein FAM241A (FAM241A)	OTC12ETA	F241A_HUMAN	Increases Expression	[10]
Interleukin-17 receptor C (IL17RC)	OTEFOBSS	I17RC_HUMAN	Increases Expression	[10]
Protein APCDD1-like (APCDD1L)	OTP7CAV5	APCDL_HUMAN	Decreases Expression	[10]
LRRN4 C-terminal-like protein (LRRN4CL)	OTJFDTVR	LRN4L_HUMAN	Increases Expression	[10]
Phospholipid phosphatase 5 (PLPP5)	OTHT51D6	PLPP5_HUMAN	Decreases Expression	[10]
Activin receptor type-1C (ACVR1C)	OTOTYERF	ACV1C_HUMAN	Increases Expression	[10]
Neuron navigator 1 (NAV1)	OT667KTL	NAV1_HUMAN	Decreases Expression	[10]
Nesprin-1 (SYNE1)	OTSBSLUH	SYNE1_HUMAN	Decreases Expression	[10]
Interleukin-17 receptor E (IL17RE)	OTMFTNLS	I17RE_HUMAN	Increases Expression	[10]
Neuroligin-2 (NLGN2)	OTHDYL3H	NLGN2_HUMAN	Decreases Expression	[10]
Tetraspanin-14 (TSPAN14)	OT29167O	TSN14_HUMAN	Increases Expression	[10]
LIM domain only protein 3 (LMO3)	OTR7AJHN	LMO3_HUMAN	Increases Expression	[10]
DEP domain-containing mTOR-interacting protein (DEPTOR)	OTCBP1BT	DPTOR_HUMAN	Increases Expression	[10]
Protein cornichon homolog 3 (CNIH3)	OTNLZ2QS	CNIH3_HUMAN	Decreases Expression	[10]
Ecto-NOX disulfide-thiol exchanger 1 (ENOX1)	OT4WOLA8	ENOX1_HUMAN	Decreases Expression	[10]
Pyridoxal phosphate phosphatase PHOSPHO2 (PHOSPHO2)	OTN3D4ZM	PHOP2_HUMAN	Increases Expression	[10]
Melanocortin-2 receptor accessory protein (MRAP)	OTLBWM7X	MRAP_HUMAN	Increases Expression	[10]
Pleckstrin homology domain-containing family O member 2 (PLEKHO2)	OT2FTK68	PKHO2_HUMAN	Increases Expression	[10]
G-protein coupled bile acid receptor 1 (GPBAR1)	OT4BKEJ9	GPBAR_HUMAN	Increases Expression	[10]
Actin filament-associated protein 1-like 1 (AFAP1L1)	OTWNTNDB	AF1L1_HUMAN	Increases Expression	[10]
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (ABHD5)	OTY829Z3	ABHD5_HUMAN	Increases Expression	[10]
Cell migration-inducing and hyaluronan-binding protein (CEMIP)	OTK80FYN	CEMIP_HUMAN	Decreases Expression	[10]
Sodium-coupled neutral amino acid transporter 5 (SLC38A5)	OTX4Q83J	S38A5_HUMAN	Decreases Expression	[10]
Protein prune homolog 2 (PRUNE2)	OTGW2974	PRUN2_HUMAN	Increases Expression	[10]
Coiled-coil domain-containing protein 107 (CCDC107)	OTF1H2TM	CC107_HUMAN	Increases Expression	[10]
RING finger protein 141 (RNF141)	OT07ANSG	RN141_HUMAN	Increases Expression	[10]
Palladin (PALLD)	OTZ2MUJZ	PALLD_HUMAN	Increases Expression	[10]
Gem-associated protein 6 (GEMIN6)	OTE262KF	GEMI6_HUMAN	Increases Expression	[10]
Nanos homolog 1 (NANOS1)	OT3UNZZY	NANO1_HUMAN	Increases Expression	[10]
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial (CHCHD10)	OTCDHAM6	CHC10_HUMAN	Increases Expression	[10]
SHC-transforming protein 3 (SHC3)	OT305NPA	SHC3_HUMAN	Increases Expression	[10]
Nuclear receptor subfamily 4 group A member 3 (NR4A3)	OTPBE9R1	NR4A3_HUMAN	Increases Expression	[10]
Receptor-type tyrosine-protein phosphatase U (PTPRU)	OTHDO0QG	PTPRU_HUMAN	Decreases Expression	[10]
Secreted frizzled-related protein 3 (FRZB)	OTTO3DPY	SFRP3_HUMAN	Increases Expression	[10]
Retinol dehydrogenase 5 (RDH5)	OTYBZHCC	RDH5_HUMAN	Increases Expression	[10]
NEDD4-binding protein 2-like 2 (N4BP2L2)	OTV2F04G	N42L2_HUMAN	Decreases Expression	[10]
Neuronal cell adhesion molecule (NRCAM)	OT80HHQ2	NRCAM_HUMAN	Increases Expression	[10]
Protein tyrosine phosphatase type IVA 1 (PTP4A1)	OTK0NFXJ	TP4A1_HUMAN	Decreases Expression	[10]
Ribonuclease P/MRP protein subunit POP5 (POP5)	OTCZTDJC	POP5_HUMAN	Increases Expression	[10]
Protein TMEPAI (PMEPA1)	OTY8Z9UF	PMEPA_HUMAN	Decreases Expression	[10]
Protein lifeguard 3 (TMBIM1)	OTE47B57	LFG3_HUMAN	Increases Expression	[10]
Antizyme inhibitor 2 (AZIN2)	OT8OB7CG	AZIN2_HUMAN	Decreases Expression	[10]
Fermitin family homolog 2 (FERMT2)	OTZNPWWX	FERM2_HUMAN	Increases Expression	[10]
Patatin-like phospholipase domain-containing protein 2 (PNPLA2)	OTR3ERMR	PLPL2_HUMAN	Increases Expression	[10]
SOSS complex subunit B2 (NABP1)	OTFTNFHW	SOSB2_HUMAN	Increases Expression	[10]
Mas-related G-protein coupled receptor member F (MRGPRF)	OT74OZ2Z	MRGRF_HUMAN	Increases Expression	[10]
Dapper homolog 3 (DACT3)	OTSNQ55G	DACT3_HUMAN	Decreases Expression	[10]
Inactive rhomboid protein 1 (RHBDF1)	OTCQ7UDS	RHDF1_HUMAN	Decreases Expression	[10]
Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2)	OTBB799S	ACSF2_HUMAN	Increases Expression	[10]
Isochorismatase domain-containing protein 1 (ISOC1)	OTAO7Z87	ISOC1_HUMAN	Increases Expression	[10]
Galectin-12 (LGALS12)	OTNTQULB	LEG12_HUMAN	Increases Expression	[10]
Transcription elongation factor A protein-like 4 (TCEAL4)	OTX24CQI	TCAL4_HUMAN	Increases Expression	[10]
C1GALT1-specific chaperone 1 (C1GALT1C1)	OTRTZUF5	C1GLC_HUMAN	Increases Expression	[10]
Small integral membrane protein 12 (SMIM12)	OTMOQSL4	SIM12_HUMAN	Increases Expression	[10]
Intraflagellar transport protein 43 homolog (IFT43)	OTKWYQ5C	IFT43_HUMAN	Decreases Expression	[10]
Kelch domain-containing protein 7B (KLHDC7B)	OT2H5BNX	KLD7B_HUMAN	Decreases Expression	[10]
Secreted frizzled-related protein 2 (SFRP2)	OT8GZ0CA	SFRP2_HUMAN	Decreases Expression	[10]
Receptor expression-enhancing protein 6 (REEP6)	OTY4FPO8	REEP6_HUMAN	Increases Expression	[10]
Succinate--CoA ligase subunit beta, mitochondrial (SUCLG2)	OT0KHLY2	SUCB2_HUMAN	Increases Expression	[10]
Calmin (CLMN)	OT7U5J3T	CLMN_HUMAN	Increases Expression	[10]
Bcl-2-modifying factor (BMF)	OT90NSLI	BMF_HUMAN	Decreases Expression	[10]
FYVE, RhoGEF and PH domain-containing protein 4 (FGD4)	OTYXJQCW	FGD4_HUMAN	Increases Expression	[10]
RIPOR family member 3 (RIPOR3)	OTHZ4RKK	RIPR3_HUMAN	Increases Expression	[10]
Pseudokinase FAM20A (FAM20A)	OT5Z5IW8	FA20A_HUMAN	Decreases Expression	[10]
Prickle-like protein 1 (PRICKLE1)	OT9HHEM9	PRIC1_HUMAN	Decreases Expression	[10]
Sterile alpha motif domain-containing protein 11 (SAMD11)	OT6WRQOX	SAM11_HUMAN	Decreases Expression	[10]
Diacylglycerol O-acyltransferase 2 (DGAT2)	OTE5PDD0	DGAT2_HUMAN	Increases Expression	[10]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Decreases Expression	[10]
Coiled-coil domain-containing protein 85A (CCDC85A)	OT2GLF5Z	CC85A_HUMAN	Increases Expression	[10]
Tribbles homolog 3 (TRIB3)	OTG5OS7X	TRIB3_HUMAN	Decreases Expression	[10]
Hemicentin-1 (HMCN1)	OTLZAS0P	HMCN1_HUMAN	Decreases Expression	[10]
Ethanolamine-phosphate cytidylyltransferase (PCYT2)	OTT8TAEA	PCY2_HUMAN	Increases Expression	[10]
Sphingosine 1-phosphate receptor 3 (S1PR3)	OTXBIYO8	S1PR3_HUMAN	Increases Expression	[10]
Sortilin (SORT1)	OTFCQ4B1	SORT_HUMAN	Increases Expression	[10]
Perilipin-2 (PLIN2)	OTRXJ9UN	PLIN2_HUMAN	Increases Expression	[10]
Monoglyceride lipase (MGLL)	OT5ES4IE	MGLL_HUMAN	Increases Expression	[10]
Collagen alpha-1(XII) chain (COL12A1)	OTHLTV53	COCA1_HUMAN	Decreases Expression	[10]
Metalloproteinase inhibitor 4 (TIMP4)	OT8A68SW	TIMP4_HUMAN	Increases Expression	[10]
MyoD family inhibitor (MDFI)	OTIA6YUG	MDFI_HUMAN	Decreases Expression	[10]
Paired mesoderm homeobox protein 2 (PRRX2)	OT8UR4AU	PRRX2_HUMAN	Decreases Expression	[10]
Protein smoothened (SMO)	OTXXE208	SMO_HUMAN	Decreases Expression	[10]
Histone H2A type 1-J (H2AC14)	OT5Y4MMC	H2A1J_HUMAN	Increases Expression	[10]
Retinoic acid receptor responder protein 2 (RARRES2)	OT1BJE8K	RARR2_HUMAN	Decreases Expression	[10]
Growth/differentiation factor 15 (GDF15)	OTWQN50N	GDF15_HUMAN	Decreases Expression	[10]
FYVE and coiled-coil domain-containing protein 1 (FYCO1)	OTKZHTZ5	FYCO1_HUMAN	Increases Expression	[10]
Calsyntenin-3 (CLSTN3)	OTPUFK4C	CSTN3_HUMAN	Decreases Expression	[10]
Ferroptosis suppressor protein 1 (AIFM2)	OT57XWXO	FSP1_HUMAN	Increases Expression	[10]
La-related protein 6 (LARP6)	OTUQ9QS9	LARP6_HUMAN	Decreases Expression	[10]
Peroxiredoxin-like 2A (PRXL2A)	OTR4X7UH	PXL2A_HUMAN	Increases Expression	[10]
Latexin (LXN)	OTZQ2M6Y	LXN_HUMAN	Decreases Expression	[10]
Transmembrane protein 204 (TMEM204)	OT7X11D9	TM204_HUMAN	Decreases Expression	[10]
Histone H2A.J (H2AJ)	OTVA4XTW	H2AJ_HUMAN	Increases Expression	[10]
Chordin-like protein 1 (CHRDL1)	OTGMWVVA	CRDL1_HUMAN	Increases Expression	[10]
Protein ABHD14A (ABHD14A)	OT94GKE1	ABHEA_HUMAN	Increases Expression	[10]
Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 (CHCHD7)	OTHHROAQ	CHCH7_HUMAN	Increases Expression	[10]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)	OTJGE772	CHAC1_HUMAN	Decreases Expression	[10]
Acetyl-CoA acetyltransferase, cytosolic (ACAT2)	OTZ092ZJ	THIC_HUMAN	Increases Expression	[10]
Sorbin and SH3 domain-containing protein 1 (SORBS1)	OTWH8762	SRBS1_HUMAN	Increases Expression	[10]
Oxysterol-binding protein-related protein 10 (OSBPL10)	OT0TFMBE	OSB10_HUMAN	Decreases Expression	[10]
EMILIN-2 (EMILIN2)	OTOYK5A8	EMIL2_HUMAN	Increases Expression	[10]
RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1)	OTOOXC7B	HOIL1_HUMAN	Decreases Expression	[10]
Protein Niban 1 (NIBAN1)	OTYOLI12	NIBA1_HUMAN	Decreases Expression	[10]
Forkhead box protein Q1 (FOXQ1)	OT6S3EB0	FOXQ1_HUMAN	Decreases Expression	[10]
Carbohydrate sulfotransferase 6 (CHST6)	OTXD2IWK	CHST6_HUMAN	Decreases Expression	[10]
N-alpha-acetyltransferase 50 (NAA50)	OTFJ8S47	NAA50_HUMAN	Increases Expression	[10]
Serine/threonine-protein kinase SIK2 (SIK2)	OTODY7XG	SIK2_HUMAN	Increases Expression	[10]
Uncharacterized protein C1orf21 (C1ORF21)	OTMD7O88	CA021_HUMAN	Increases Expression	[10]
Solute carrier family 25 member 32 (SLC25A32)	OTPP3NWG	S2532_HUMAN	Increases Expression	[10]
Ras association domain-containing protein 4 (RASSF4)	OT7YLOFH	RASF4_HUMAN	Increases Expression	[10]
Forkhead box protein P1 (FOXP1)	OTSG6XGF	FOXP1_HUMAN	Decreases Expression	[10]
SPARC-related modular calcium-binding protein 2 (SMOC2)	OTK1EQ49	SMOC2_HUMAN	Increases Expression	[10]
Serine/threonine-protein kinase PLK3 (PLK3)	OT19CT2Z	PLK3_HUMAN	Decreases Expression	[10]
Regulator of cell cycle RGCC (RGCC)	OTYJMLWM	RGCC_HUMAN	Increases Expression	[10]
Very long chain fatty acid elongase 6 (ELOVL6)	OTB26UJJ	ELOV6_HUMAN	Increases Expression	[10]
IGF-like family receptor 1 (IGFLR1)	OTPUCWQR	IGFR1_HUMAN	Increases Expression	[10]
Reticulophagy regulator 1 (RETREG1)	OTYOSLZX	RETR1_HUMAN	Increases Expression	[10]
Anthrax toxin receptor 1 (ANTXR1)	OT5W1GPC	ANTR1_HUMAN	Decreases Expression	[10]
Gremlin-2 (GREM2)	OTE91EWT	GREM2_HUMAN	Decreases Expression	[10]
Protein eva-1 homolog A (EVA1A)	OTCY3Q2M	EVA1A_HUMAN	Decreases Expression	[10]
RING finger protein 122 (RNF122)	OT8RE3IM	RN122_HUMAN	Decreases Expression	[10]
Interleukin-21 receptor (IL21R)	OTDIOB63	IL21R_HUMAN	Decreases Expression	[10]
MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2)	OTNA9G8V	MKNK2_HUMAN	Increases Expression	[10]
Mitochondrial thiamine pyrophosphate carrier (SLC25A19)	OT157TY3	TPC_HUMAN	Increases Expression	[10]
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM)	OTR1XD9B	GPAT1_HUMAN	Increases Expression	[10]
Plexin-A4 (PLXNA4)	OT5XKB3Q	PLXA4_HUMAN	Increases Expression	[10]
Solute carrier family 40 member 1 (SLC40A1)	OT8RV2VY	S40A1_HUMAN	Increases Expression	[10]
Carbohydrate-responsive element-binding protein (MLXIPL)	OTR9MLLW	MLXPL_HUMAN	Increases Expression	[10]
Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A)	OT5V52LN	TNR12_HUMAN	Decreases Expression	[10]
G-protein coupled receptor family C group 5 member C (GPRC5C)	OT45AJT3	GPC5C_HUMAN	Decreases Expression	[10]
Omega-amidase NIT2 (NIT2)	OTC1RAH3	NIT2_HUMAN	Increases Expression	[10]
PDZ and LIM domain protein 7 (PDLIM7)	OTAZVODU	PDLI7_HUMAN	Decreases Expression	[10]
Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2)	OTB1FZJU	ACSA_HUMAN	Increases Expression	[10]
Sialin (SLC17A5)	OTM5EC0O	S17A5_HUMAN	Increases Expression	[10]
Teashirt homolog 2 (TSHZ2)	OTZWBXXY	TSH2_HUMAN	Decreases Expression	[10]
NADH dehydrogenase 1 alpha subcomplex subunit 4-like 2 (NDUFA4L2)	OTK0PG7R	NUA4L_HUMAN	Decreases Expression	[10]
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4)	OT5CTQKO	PLCD_HUMAN	Decreases Expression	[10]
Semaphorin-3G (SEMA3G)	OTBLVF8V	SEM3G_HUMAN	Increases Expression	[10]
Protein C19orf12 (C19ORF12)	OTVSJ1AR	CS012_HUMAN	Increases Expression	[10]
Teneurin-2 (TENM2)	OTPLUYEF	TEN2_HUMAN	Decreases Expression	[10]
Protein DEPP1 (DEPP1)	OTB36PHJ	DEPP1_HUMAN	Increases Expression	[10]
Copper homeostasis protein cutC homolog (CUTC)	OTOVHLU9	CUTC_HUMAN	Increases Expression	[10]
PI-PLC X domain-containing protein 1 (PLCXD1)	OTU7KCQL	PLCX1_HUMAN	Increases Expression	[10]
Fas apoptotic inhibitory molecule 1 (FAIM)	OTR67PGU	FAIM1_HUMAN	Increases Expression	[10]
Spermine oxidase (SMOX)	OT11E62Y	SMOX_HUMAN	Decreases Expression	[10]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Decreases Expression	[10]
Myotubularin-related protein 10 (MTMR10)	OTF6DB4O	MTMRA_HUMAN	Increases Expression	[10]
Dapper homolog 1 (DACT1)	OT19Z704	DACT1_HUMAN	Decreases Expression	[10]
Very long chain fatty acid elongase 5 (ELOVL5)	OT375W1Z	ELOV5_HUMAN	Increases Expression	[10]
Serine/threonine-protein kinase PLK2 (PLK2)	OTKMJXJ8	PLK2_HUMAN	Decreases Expression	[10]
Potassium voltage-gated channel subfamily D member 2 (KCND2)	OTIFUVV7	KCND2_HUMAN	Decreases Expression	[10]
Ankycorbin (RAI14)	OT6USGBK	RAI14_HUMAN	Decreases Expression	[10]
Neurotrimin (NTM)	OTHF0UQU	NTRI_HUMAN	Decreases Expression	[10]
Rho GTPase-activating protein 20 (ARHGAP20)	OTG1STV8	RHG20_HUMAN	Increases Expression	[10]
Signal-induced proliferation-associated 1-like protein 2 (SIPA1L2)	OT8NJE5D	SI1L2_HUMAN	Decreases Expression	[10]
]-phosphatase 2, mitochondrial (PDP2)	OTADNMGK	PDP2_HUMAN	Increases Expression	[10]
A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9)	OTV3Q0DS	ATS9_HUMAN	Increases Expression	[10]
Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)	OTSB4XO0	DPM3_HUMAN	Increases Expression	[10]
SUMO-activating enzyme subunit 1 (SAE1)	OT18HFX5	SAE1_HUMAN	Decreases Expression	[10]
C-type mannose receptor 2 (MRC2)	OTLWQAX1	MRC2_HUMAN	Decreases Expression	[10]
ATP-binding cassette sub-family D member 2 (ABCD2)	OT8RGNH8	ABCD2_HUMAN	Increases Expression	[10]
Copine-7 (CPNE7)	OTR0FJ8A	CPNE7_HUMAN	Increases Expression	[10]
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D)	OTOSRDJT	TR10D_HUMAN	Decreases Expression	[10]
Heat shock protein beta-7 (HSPB7)	OTLATAOV	HSPB7_HUMAN	Increases Expression	[10]
Tight junction protein ZO-2 (TJP2)	OTQUY6BV	ZO2_HUMAN	Increases Expression	[10]
Gamma-adducin (ADD3)	OTDRSHAZ	ADDG_HUMAN	Increases Expression	[10]
5'-AMP-activated protein kinase subunit gamma-2 (PRKAG2)	OTHTAM54	AAKG2_HUMAN	Increases Expression	[10]
Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6)	OTVUZCLG	GTR6_HUMAN	Increases Expression	[10]
Sushi domain-containing protein 2 (SUSD2)	OTSJTAZP	SUSD2_HUMAN	Increases Expression	[10]
Zinc finger transcription factor Trps1 (TRPS1)	OT7XPPEL	TRPS1_HUMAN	Decreases Expression	[10]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)	OTTLJH8W	ATS1_HUMAN	Increases Expression	[10]
Potassium voltage-gated channel subfamily G member 1 (KCNG1)	OTZ9ZRG8	KCNG1_HUMAN	Decreases Expression	[10]
ERBB receptor feedback inhibitor 1 (ERRFI1)	OT7VZ2IZ	ERRFI_HUMAN	Increases Expression	[10]
A-kinase anchor protein 11 (AKAP11)	OT7E2FVD	AKA11_HUMAN	Decreases Expression	[10]
A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAMTS6)	OTSZE6L4	ATS6_HUMAN	Decreases Expression	[10]
Integrin alpha-11 (ITGA11)	OTBWSRA1	ITA11_HUMAN	Decreases Expression	[10]
Long-chain-fatty-acid--CoA ligase 5 (ACSL5)	OT3L9XO3	ACSL5_HUMAN	Increases Expression	[10]
Frizzled-4 (FZD4)	OTGLZIE0	FZD4_HUMAN	Increases Expression	[10]
RING finger protein 112 (RNF112)	OT0Q9OUQ	RN112_HUMAN	Decreases Expression	[10]
Synaptopodin-2 (SYNPO2)	OTC3U0YH	SYNP2_HUMAN	Increases Expression	[10]
Protein NDRG2 (NDRG2)	OT5L6KD7	NDRG2_HUMAN	Increases Expression	[10]
Endothelial protein C receptor (PROCR)	OTRHED17	EPCR_HUMAN	Increases Expression	[10]
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C)	OTEU05TX	PPR3C_HUMAN	Decreases Expression	[10]
HIG1 domain family member 1A, mitochondrial (HIGD1A)	OTS351DV	HIG1A_HUMAN	Increases Expression	[10]
Dexamethasone-induced Ras-related protein 1 (RASD1)	OT2BAJHK	RASD1_HUMAN	Increases Expression	[10]
Cyclic AMP-dependent transcription factor ATF-5 (ATF5)	OT03QCLM	ATF5_HUMAN	Decreases Expression	[10]
Kelch-like protein 20 (KLHL20)	OTC0SFS9	KLH20_HUMAN	Increases Expression	[10]
Calcium-regulated heat-stable protein 1 (CARHSP1)	OTAUG6Y9	CHSP1_HUMAN	Decreases Expression	[10]
Deoxyribose-phosphate aldolase (DERA)	OT8SMO3N	DEOC_HUMAN	Increases Expression	[10]
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMHD1)	OTBCIBC7	SAMH1_HUMAN	Increases Expression	[10]
C2 domain-containing protein 2 (C2CD2)	OTL1K0OB	C2CD2_HUMAN	Increases Expression	[10]
Lysyl oxidase homolog 2 (LOXL2)	OTRT46B5	LOXL2_HUMAN	Decreases Expression	[10]
ADP-ribose glycohydrolase OARD1 (OARD1)	OTNNWATS	OARD1_HUMAN	Decreases Expression	[10]
Ankyrin repeat and SOCS box protein 1 (ASB1)	OT0NZGEI	ASB1_HUMAN	Decreases Expression	[10]
Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B)	OTGZO1MT	TIM8B_HUMAN	Increases Expression	[10]
Retinoic acid-induced protein 2 (RAI2)	OTR8LX4J	RAI2_HUMAN	Increases Expression	[10]
Mitochondrial pyruvate carrier 1 (MPC1)	OT6DYFUO	MPC1_HUMAN	Increases Expression	[10]
Melanoma-associated antigen D1 (MAGED1)	OT6EOLFC	MAGD1_HUMAN	Decreases Expression	[10]
Cysteine sulfinic acid decarboxylase (CSAD)	OT3I2G0A	CSAD_HUMAN	Increases Expression	[10]
Glypican-6 (GPC6)	OTNJBESF	GPC6_HUMAN	Decreases Expression	[10]
Inositol 1,4,5-triphosphate receptor associated 1 (IRAG1)	OTMRW5U5	IRAG1_HUMAN	Increases Expression	[10]
Sulfide:quinone oxidoreductase, mitochondrial (SQOR)	OTTLD0KB	SQOR_HUMAN	Increases Expression	[10]
SET-binding protein (SETBP1)	OTKGCOSR	SETBP_HUMAN	Decreases Expression	[10]
Tryptophan 2,3-dioxygenase (TDO2)	OTV5HKJ4	T23O_HUMAN	Increases Expression	[54]
Serum paraoxonase/arylesterase 1 (PON1)	OTD0Z2XO	PON1_HUMAN	Increases Expression	[55]
Collagen alpha-1(II) chain (COL2A1)	OT5E59C8	CO2A1_HUMAN	Decreases Expression	[56]
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)	OTG7J4BP	PPBT_HUMAN	Increases Expression	[56]
Aggrecan core protein (ACAN)	OTUOCW8K	PGCA_HUMAN	Decreases Expression	[56]
Transcription factor SOX-9 (SOX9)	OTVDJFGN	SOX9_HUMAN	Decreases Expression	[56]
Collagen alpha-1(X) chain (COL10A1)	OTC4G2YC	COAA1_HUMAN	Increases Expression	[56]
Indian hedgehog protein (IHH)	OT1DWGXC	IHH_HUMAN	Increases Expression	[56]
Glutathione S-transferase A1 (GSTA1)	OTA7K5XA	GSTA1_HUMAN	Increases Expression	[57]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)	OTQ4W7MT	TR11B_HUMAN	Decreases Expression	[58]
Basic helix-loop-helix ARNT-like protein 1 (BMAL1)	OTMI12L2	BMAL1_HUMAN	Affects Expression	[59]
Syntenin-1 (SDCBP)	OTS3NCC5	SDCB1_HUMAN	Increases Expression	[14]
Transcription factor SOX-1 (SOX1)	OTVI1RAR	SOX1_HUMAN	Increases Expression	[60]
Proepiregulin (EREG)	OTRM4NQY	EREG_HUMAN	Increases Expression	[61]
Calsequestrin-2 (CASQ2)	OT09MNQ8	CASQ2_HUMAN	Affects Expression	[60]
Period circadian protein homolog 2 (PER2)	OTU2B1DJ	PER2_HUMAN	Affects Expression	[59]
Solute carrier family 22 member 1 (SLC22A1)	OT7817I4	S22A1_HUMAN	Increases Expression	[62]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Affects Expression	[63]
Transmembrane protease serine 2 (TMPRSS2)	OTN44YQ5	TMPS2_HUMAN	Increases Expression	[64]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Increases Expression	[65]
Toll-like receptor 3 (TLR3)	OT8QPYXZ	TLR3_HUMAN	Decreases Expression	[66]
Circadian locomoter output cycles protein kaput (CLOCK)	OTNEOJY7	CLOCK_HUMAN	Affects Expression	[59]
Suppressor of cytokine signaling 1 (SOCS1)	OTWA9KFU	SOCS1_HUMAN	Increases Expression	[66]
SLIT-ROBO Rho GTPase-activating protein 3 (SRGAP3)	OT9ZS72C	SRGP3_HUMAN	Increases Expression	[67]
Carbonic anhydrase 12 (CA12)	OT6WNFU8	CAH12_HUMAN	Increases Expression	[15]
Neuronal migration protein doublecortin (DCX)	OTISR7K3	DCX_HUMAN	Increases Expression	[60]
Glucose-6-phosphate exchanger SLC37A4 (SLC37A4)	OTLCYA32	G6PT1_HUMAN	Increases Expression	[68]
Left-right determination factor 1 (LEFTY1)	OT51HVC4	LFTY1_HUMAN	Increases Expression	[15]
Dickkopf-related protein 1 (DKK1)	OTRDLUSP	DKK1_HUMAN	Increases Expression	[69]
Sciellin (SCEL)	OT46SDNQ	SCEL_HUMAN	Increases Expression	[14]
Homeobox protein SIX3 (SIX3)	OTP5E3VU	SIX3_HUMAN	Increases Expression	[60]
Transforming acidic coiled-coil-containing protein 2 (TACC2)	OTW4M7HI	TACC2_HUMAN	Increases Expression	[70]
Eyes absent homolog 4 (EYA4)	OTINGR3Z	EYA4_HUMAN	Affects Expression	[60]
Interleukin-33 (IL33)	OTT5YWK3	IL33_HUMAN	Decreases Expression	[71]
Claudin-1 (CLDN1)	OT27KV99	CLD1_HUMAN	Increases Expression	[11]
Eomesodermin homolog (EOMES)	OTB9VQFA	EOMES_HUMAN	Increases Expression	[60]
T-box transcription factor TBX6 (TBX6)	OTW1Q8RM	TBX6_HUMAN	Affects Expression	[60]
Prothrombin (F2)	OTNFSM49	THRB_HUMAN	Affects Expression	[60]
Renin (REN)	OT52GZR2	RENI_HUMAN	Increases Activity	[72]
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Decreases Expression	[73]
Alpha-1-antitrypsin (SERPINA1)	OTACYW9J	A1AT_HUMAN	Decreases Expression	[74]
Low-density lipoprotein receptor (LDLR)	OTH559LU	LDLR_HUMAN	Decreases Expression	[75]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Decreases Expression	[76]
Pro-opiomelanocortin (POMC)	OTV41F7T	COLI_HUMAN	Decreases Expression	[72]
Prolactin (PRL)	OTWFQGX7	PRL_HUMAN	Increases Expression	[77]
Insulin (INS)	OTZ85PDU	INS_HUMAN	Decreases Response To Substance	[78]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Decreases Expression	[79]
Interferon gamma (IFNG)	OTXG9JM7	IFNG_HUMAN	Decreases Expression	[30]
Interleukin-2 receptor subunit alpha (IL2RA)	OT0MWCHG	IL2RA_HUMAN	Decreases Expression	[80]
T-cell surface glycoprotein CD4 (CD4)	OT7Z5LNF	CD4_HUMAN	Decreases Expression	[81]
HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA)	OT7KZMP2	DRA_HUMAN	Increases Expression	[66]
HLA class II histocompatibility antigen, DQ alpha 1 chain (HLA-DQA1)	OTC6GISG	DQA1_HUMAN	Increases Expression	[66]
HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1)	OTRGGIFP	DRB1_HUMAN	Decreases Expression	[82]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1)	OTVVI3UI	DQB1_HUMAN	Affects Expression	[66]
Alpha-crystallin B chain (CRYAB)	OTY4JGYU	CRYAB_HUMAN	Increases Expression	[83]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Decreases Expression	[74]
Annexin A1 (ANXA1)	OT5OFDJC	ANXA1_HUMAN	Increases Expression	[84]
Granulocyte-macrophage colony-stimulating factor (CSF2)	OT1M7D28	CSF2_HUMAN	Decreases Expression	[30]
HLA class II histocompatibility antigen, DP beta 1 chain (HLA-DPB1)	OTW8JHU2	DPB1_HUMAN	Increases Expression	[66]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Decreases Expression	[85]
Metallothionein-1E (MT1E)	OTXJKU4Y	MT1E_HUMAN	Increases Expression	[14]
Insulin-like growth factor I (IGF1)	OTIIZR61	IGF1_HUMAN	Decreases Expression	[86]
Protein S100-A8 (S100A8)	OTVMOB3F	S10A8_HUMAN	Increases Expression	[87]
Interleukin-5 (IL5)	OTAFPSCO	IL5_HUMAN	Decreases Expression	[30]
Plasminogen activator inhibitor 1 (SERPINE1)	OTT0MPQ3	PAI1_HUMAN	Increases Expression	[88]
Myeloperoxidase (MPO)	OTOOXLIN	PERM_HUMAN	Affects Expression	[60]
Intercellular adhesion molecule 1 (ICAM1)	OTTOIX77	ICAM1_HUMAN	Decreases Expression	[13]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Increases Phosphorylation	[89]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Increases Expression	[67]
Protein S100-A9 (S100A9)	OTOARHCS	S10A9_HUMAN	Increases Expression	[87]
Beta-2 adrenergic receptor (ADRB2)	OTSDOX4Q	ADRB2_HUMAN	Increases Expression	[90]
Heat shock protein HSP 90-alpha (HSP90AA1)	OTLG1WPK	HS90A_HUMAN	Increases Expression	[83]
Tyrosine-protein kinase Lyn (LYN)	OTP686K2	LYN_HUMAN	Affects Expression	[66]
Beta-microseminoprotein (MSMB)	OTYORAJC	MSMB_HUMAN	Increases Expression	[15]
Corticosteroid-binding globulin (SERPINA6)	OTOIBEW7	CBG_HUMAN	Increases Expression	[91]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Decreases Expression	[11]
Monocyte differentiation antigen CD14 (CD14)	OT83GJ47	CD14_HUMAN	Increases Expression	[92]
Receptor-type tyrosine-protein phosphatase C (PTPRC)	OT6KOR77	PTPRC_HUMAN	Affects Expression	[60]
Interleukin-3 (IL3)	OT0CQ35N	IL3_HUMAN	Decreases Expression	[30]
Interleukin-6 receptor subunit alpha (IL6R)	OTCQL07Z	IL6RA_HUMAN	Increases Expression	[93]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[94]
Granulocyte colony-stimulating factor (CSF3)	OT9GC6TP	CSF3_HUMAN	Increases Expression	[14]
Transmembrane protein 191B (TMEM191B)	OTDKHB0K	T191B_HUMAN	Decreases Expression	[15]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Decreases Expression	[95]
Transcriptional activator Myb (MYB)	OTJH64IV	MYB_HUMAN	Increases Expression	[14]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Decreases Expression	[86]
Transforming growth factor beta-3 proprotein (TGFB3)	OT2LOUQ1	TGFB3_HUMAN	Increases Expression	[14]
Phenylethanolamine N-methyltransferase (PNMT)	OTGLCPE8	PNMT_HUMAN	Increases Expression	[15]
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Increases Expression	[67]
Pulmonary surfactant-associated protein C (SFTPC)	OTIZJD09	PSPC_HUMAN	Increases Expression	[96]
Proliferating cell nuclear antigen (PCNA)	OTHZ1RIA	PCNA_HUMAN	Decreases Expression	[97]
Parathyroid hormone-related protein (PTHLH)	OTI1JF13	PTHR_HUMAN	Decreases Expression	[98]
Myosin-7 (MYH7)	OT4Z9T8N	MYH7_HUMAN	Increases Expression	[60]
Myosin-6 (MYH6)	OT3YNCH1	MYH6_HUMAN	Affects Expression	[60]
Metallothionein-1G (MT1G)	OTAV1OCR	MT1G_HUMAN	Increases Expression	[14]
Tissue factor (F3)	OT3MSU3B	TF_HUMAN	Increases Expression	[99]
Glial fibrillary acidic protein (GFAP)	OTQ01ZAS	GFAP_HUMAN	Increases Expression	[69]
Hepatocyte growth factor (HGF)	OTGHUA23	HGF_HUMAN	Decreases Expression	[100]
G2/mitotic-specific cyclin-B1 (CCNB1)	OT19S7E5	CCNB1_HUMAN	Increases Expression	[67]
Interleukin-2 receptor subunit beta (IL2RB)	OT6M0F70	IL2RB_HUMAN	Decreases Expression	[80]
Protein C-ets-2 (ETS2)	OTPVHOZ7	ETS2_HUMAN	Increases Expression	[66]
Mucin-1 (MUC1)	OTHQI7IY	MUC1_HUMAN	Increases Expression	[101]
Cyclic AMP-responsive element-binding protein 1 (CREB1)	OT1MDLA1	CREB1_HUMAN	Increases Phosphorylation	[102]
Methylated-DNA--protein-cysteine methyltransferase (MGMT)	OT40A9WH	MGMT_HUMAN	Increases Expression	[103]
Protein kinase C alpha type (PRKCA)	OT5UWNRD	KPCA_HUMAN	Affects Expression	[66]
Syndecan-1 (SDC1)	OTWKRVZC	SDC1_HUMAN	Decreases Expression	[104]
Transcobalamin-2 (TCN2)	OT41D0L3	TCO2_HUMAN	Decreases Expression	[66]
Cyclin-A2 (CCNA2)	OTPHHYZJ	CCNA2_HUMAN	Increases Expression	[67]
Nuclear receptor subfamily 1 group D member 1 (NR1D1)	OTJ38PTB	NR1D1_HUMAN	Decreases Expression	[105]
fMet-Leu-Phe receptor (FPR1)	OTFF9I6W	FPR1_HUMAN	Increases Expression	[85]
C-type natriuretic peptide (NPPC)	OTYJ0LMA	ANFC_HUMAN	Increases Expression	[15]
Paired box protein Pax-3 (PAX3)	OTN5PJZV	PAX3_HUMAN	Affects Expression	[60]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Decreases Expression	[69]
Cyclin-dependent kinase 2 (CDK2)	OTB5DYYZ	CDK2_HUMAN	Decreases Expression	[106]
Alpha-1D adrenergic receptor (ADRA1D)	OTW2CD1O	ADA1D_HUMAN	Increases Expression	[107]
Proteinase-activated receptor 1 (F2R)	OT4WVWBO	PAR1_HUMAN	Increases Expression	[108]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Increases Expression	[109]
NF-kappa-B inhibitor alpha (NFKBIA)	OTFT924M	IKBA_HUMAN	Increases Expression	[66]
Paired box protein Pax-6 (PAX6)	OTOC9876	PAX6_HUMAN	Increases Expression	[60]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Decreases Activity	[110]
Interleukin-1 receptor type 2 (IL1R2)	OT0G7E35	IL1R2_HUMAN	Increases Expression	[82]
Proteasome subunit beta type-9 (PSMB9)	OTFV57T8	PSB9_HUMAN	Decreases Expression	[73]
HLA class II histocompatibility antigen, DM beta chain (HLA-DMB)	OT17HGXJ	DMB_HUMAN	Decreases Expression	[111]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Decreases Activity	[110]
Dual specificity protein phosphatase 1 (DUSP1)	OTN6BR75	DUS1_HUMAN	Increases Expression	[14]
G1/S-specific cyclin-D2 (CCND2)	OTDULQF9	CCND2_HUMAN	Decreases Expression	[112]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Decreases Phosphorylation	[113]
Macrosialin (CD68)	OTOYEY3J	CD68_HUMAN	Increases Expression	[92]
Alpha-1B adrenergic receptor (ADRA1B)	OTSAYAFD	ADA1B_HUMAN	Increases Expression	[107]
Insulin receptor substrate 1 (IRS1)	OTNO82CU	IRS1_HUMAN	Decreases Expression	[71]
Glucose-6-phosphatase catalytic subunit 1 (G6PC1)	OTJ6FM9F	G6PC1_HUMAN	Decreases Expression	[91]
Chitinase-3-like protein 1 (CHI3L1)	OT2Z7VJH	CH3L1_HUMAN	Decreases Expression	[114]
Receptor-type tyrosine-protein kinase FLT3 (FLT3)	OTMSRYMK	FLT3_HUMAN	Affects Expression	[60]
GMP reductase 1 (GMPR)	OTERWHYM	GMPR1_HUMAN	Increases Expression	[15]
TGF-beta receptor type-2 (TGFBR2)	OT3P7GZP	TGFR2_HUMAN	Increases Expression	[66]
Peroxisome proliferator-activated receptor gamma (PPARG)	OTHMARHO	PPARG_HUMAN	Increases Expression	[115]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[77]
Interleukin-15 (IL15)	OTQSYWQS	IL15_HUMAN	Increases Expression	[14]
Leptin (LEP)	OT5Q7ODW	LEP_HUMAN	Increases Expression	[116]
Signal transducer and activator of transcription 5A (STAT5A)	OTBSJGN3	STA5A_HUMAN	Affects Activity	[117]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)	OTTOMI8J	PK3CA_HUMAN	Affects Expression	[31]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Decreases Activity	[118]
Interleukin-12 receptor subunit beta-1 (IL12RB1)	OTM1IJO2	I12R1_HUMAN	Decreases Expression	[119]
Nuclear receptor subfamily 4 group A member 2 (NR4A2)	OT3F9IR2	NR4A2_HUMAN	Increases Expression	[60]
Transcription factor GATA-4 (GATA4)	OTQHWAZG	GATA4_HUMAN	Increases Expression	[60]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Affects Expression	[31]
Proliferation marker protein Ki-67 (MKI67)	OTA8N1QI	KI67_HUMAN	Decreases Expression	[69]
5-hydroxytryptamine receptor 3A (HTR3A)	OTAIV1AK	5HT3A_HUMAN	Decreases Activity	[120]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Decreases Expression	[121]
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)	OTI2OREX	MP2K3_HUMAN	Increases Expression	[122]
Tumor necrosis factor ligand superfamily member 6 (FASLG)	OTZARCHH	TNFL6_HUMAN	Decreases Expression	[123]
G protein-activated inward rectifier potassium channel 4 (KCNJ5)	OTA2MBIE	KCNJ5_HUMAN	Affects Expression	[60]
Nestin (NES)	OTZ9PZ14	NEST_HUMAN	Increases Expression	[60]
Sodium/hydrogen exchanger 3 (SLC9A3)	OTZ7PFVT	SL9A3_HUMAN	Increases Expression	[124]
Steroidogenic acute regulatory protein, mitochondrial (STAR)	OTFEZ5AI	STAR_HUMAN	Decreases Expression	[125]
CCAAT/enhancer-binding protein alpha (CEBPA)	OTOM9OE4	CEBPA_HUMAN	Increases Expression	[126]
Cyclin-dependent kinase inhibitor 1C (CDKN1C)	OTASTJ3Q	CDN1C_HUMAN	Increases Expression	[77]
Amiloride-sensitive sodium channel subunit beta (SCNN1B)	OT61QQTL	SCNNB_HUMAN	Increases Expression	[127]
Amiloride-sensitive sodium channel subunit gamma (SCNN1G)	OTSJYQVQ	SCNNG_HUMAN	Increases Expression	[127]
C-C chemokine receptor type 3 (CCR3)	OT6GBUFA	CCR3_HUMAN	Decreases Expression	[128]
Signal transducer and activator of transcription 5B (STAT5B)	OTZVPEBT	STA5B_HUMAN	Increases Activity	[117]
cAMP-dependent protein kinase catalytic subunit PRKX (PRKX)	OTDAC6Z0	PRKX_HUMAN	Increases Expression	[14]
Thyroxine 5-deiodinase (DIO3)	OTNTITOT	IOD3_HUMAN	Decreases Activity	[129]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Activity	[130]
Transcription factor SOX-10 (SOX10)	OTF25ULQ	SOX10_HUMAN	Increases Expression	[60]
Forkhead box protein L2 (FOXL2)	OTFRQUYL	FOXL2_HUMAN	Decreases Expression	[121]
Interleukin-2 (IL2)	OTGI4NSA	IL2_HUMAN	Decreases Expression	[131]
C-X-C chemokine receptor type 4 (CXCR4)	OTUFSBX2	CXCR4_HUMAN	Increases Expression	[132]
Beta-2-microglobulin (B2M)	OTDWN6NX	B2MG_HUMAN	Decreases Expression	[133]
Transforming growth factor beta-2 proprotein (TGFB2)	OTC0TXEP	TGFB2_HUMAN	Decreases Expression	[76]
Histone H3.1 (H3C1)	OTGBGOZW	H31_HUMAN	Increases Expression	[67]
Heat shock factor protein 1 (HSF1)	OTYNJ4KP	HSF1_HUMAN	Increases Activity	[134]
Heterogeneous nuclear ribonucleoprotein U (HNRNPU)	OTLQN1E2	HNRPU_HUMAN	Affects Localization	[135]
DNA-binding protein inhibitor ID-2 (ID2)	OT0U1D53	ID2_HUMAN	Decreases Expression	[69]
Paired box protein Pax-5 (PAX5)	OTYBJJWX	PAX5_HUMAN	Affects Expression	[60]
Urokinase plasminogen activator surface receptor (PLAUR)	OTIRKKEQ	UPAR_HUMAN	Decreases Expression	[66]
Elongation factor 1-alpha 2 (EEF1A2)	OT9Z23K5	EF1A2_HUMAN	Increases Expression	[14]
Homeobox protein engrailed-1 (EN1)	OT2DKIDK	HME1_HUMAN	Increases Expression	[60]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Increases Expression	[136]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Increases Expression	[14]
Steroidogenic factor 1 (NR5A1)	OTOULYR4	STF1_HUMAN	Decreases Expression	[125]
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)	OT404F9K	FKBP5_HUMAN	Increases Expression	[66]
Sequestosome-1 (SQSTM1)	OTGY5D5J	SQSTM_HUMAN	Decreases Expression	[97]
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1)	OT6VY3A3	SPTN1_HUMAN	Increases Cleavage	[113]
Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1)	OTX7MWW1	ITPR1_HUMAN	Increases Expression	[67]
Receptor tyrosine-protein kinase erbB-4 (ERBB4)	OT9L6C41	ERBB4_HUMAN	Increases Expression	[14]
Mitogen-activated protein kinase 14 (MAPK14)	OT5TCO3O	MK14_HUMAN	Increases Activity	[137]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Increases Expression	[112]
Leukotriene C4 synthase (LTC4S)	OT3XNFJZ	LTC4S_HUMAN	Increases Expression	[138]
Protein Largen (PRR16)	OTG4TEGR	LARGN_HUMAN	Increases Expression	[15]
Zinc finger protein PLAG1 (PLAG1)	OTT9AJQY	PLAG1_HUMAN	Increases Expression	[14]
Beclin 1-associated autophagy-related key regulator (ATG14)	OTPZDKI0	BAKOR_HUMAN	Increases Expression	[97]
Histone H3.2 (H3C13)	OT97FS6C	H32_HUMAN	Increases Expression	[67]
Cytochrome P450 4Z1 (CYP4Z1)	OTKRGJBG	CP4Z1_HUMAN	Increases Expression	[139]
Secreted frizzled-related protein 1 (SFRP1)	OT0U9G41	SFRP1_HUMAN	Increases Expression	[14]
ATP-dependent RNA helicase TDRD9 (TDRD9)	OTS4UBI8	TDRD9_HUMAN	Increases Expression	[15]
Microprocessor complex subunit DGCR8 (DGCR8)	OT62LXE4	DGCR8_HUMAN	Increases Expression	[75]
Aquaporin-3 (AQP3)	OT2J7JPD	AQP3_HUMAN	Increases Expression	[140]
Estrogen receptor beta (ESR2)	OTXNR2WQ	ESR2_HUMAN	Increases Expression	[71]
Ras-responsive element-binding protein 1 (RREB1)	OT62460U	RREB1_HUMAN	Increases Expression	[14]
Hyaluronan synthase 2 (HAS2)	OTTD3PAL	HYAS2_HUMAN	Decreases Expression	[141]
Neurogenin-1 (NEUROG1)	OTMJZP9G	NGN1_HUMAN	Decreases Expression	[15]
Paired mesoderm homeobox protein 2B (PHOX2B)	OT3SFR2O	PHX2B_HUMAN	Affects Expression	[60]
Interleukin-12 receptor subunit beta-2 (IL12RB2)	OTDLV8H8	I12R2_HUMAN	Decreases Expression	[119]
Cbp/p300-interacting transactivator 1 (CITED1)	OTUJQ3VL	CITE1_HUMAN	Decreases Expression	[60]
Myocilin (MYOC)	OT6DAHNF	MYOC_HUMAN	Increases Expression	[83]
Mesoderm posterior protein 1 (MESP1)	OTY5QDBN	MESP1_HUMAN	Decreases Expression	[60]
Chitinase domain-containing protein 1 (CHID1)	OT4DIUKC	CHID1_HUMAN	Increases Expression	[114]
Angiotensin-converting enzyme 2 (ACE2)	OTTRZGU7	ACE2_HUMAN	Decreases Expression	[64]
Negative elongation factor A (NELFA)	OT7O6E84	NELFA_HUMAN	Increases Expression	[14]
Rho-related GTP-binding protein RhoJ (RHOJ)	OTWI65OA	RHOJ_HUMAN	Increases Expression	[67]
Glucose-6-phosphatase 2 (G6PC2)	OTET1IKU	G6PC2_HUMAN	Increases Expression	[68]
Diablo IAP-binding mitochondrial protein (DIABLO)	OTHJ9MCZ	DBLOH_HUMAN	Affects Localization	[142]
Fibroblast growth factor 21 (FGF21)	OT3RXVRD	FGF21_HUMAN	Increases Expression	[143]
G2 and S phase-expressed protein 1 (GTSE1)	OTPP742Z	GTSE1_HUMAN	Increases Expression	[67]
FERM domain-containing protein 4A (FRMD4A)	OTJDTIK2	FRM4A_HUMAN	Decreases Expression	[15]
Vesicular glutamate transporter 2 (SLC17A6)	OTP1MJGP	VGLU2_HUMAN	Increases Expression	[60]
ETS-related transcription factor Elf-5 (ELF5)	OTLRU8YF	ELF5_HUMAN	Decreases Expression	[15]
Endoribonuclease Dicer (DICER1)	OTTVSEY0	DICER_HUMAN	Increases Expression	[75]
Histone deacetylase 5 (HDAC5)	OTWG387P	HDAC5_HUMAN	Increases Expression	[125]
Hepatocyte nuclear factor 3-beta (FOXA2)	OTJOCVOY	FOXA2_HUMAN	Decreases Expression	[60]
Potassium voltage-gated channel subfamily E member 2 (KCNE2)	OTUO214Y	KCNE2_HUMAN	Affects Expression	[60]
Mitogen-activated protein kinase 11 (MAPK11)	OT0AS010	MK11_HUMAN	Increases ADR	[34]
Aromatic-L-amino-acid decarboxylase (DDC)	OT0TSW09	DDC_HUMAN	Increases ADR	[34]
Islet amyloid polypeptide (IAPP)	OT5Z8ERW	IAPP_HUMAN	Increases ADR	[34]
Programmed cell death protein 5 (PDCD5)	OT6T2DDL	PDCD5_HUMAN	Increases Response To Substance	[144]
Cadherin-4 (CDH4)	OT8LH3HN	CADH4_HUMAN	Increases ADR	[34]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Response To Substance	[145]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Response To Substance	[146]
Glucocorticoid receptor (NR3C1)	OTCI2YDI	GCR_HUMAN	Decreases Response To Substance	[147]
Gastrin (GAST)	OTD0IP9N	GAST_HUMAN	Increases ADR	[34]
Cadherin-12 (CDH12)	OTF2HCGA	CAD12_HUMAN	Increases ADR	[34]
Heat shock protein beta-1 (HSPB1)	OTHFZ8ED	HSPB1_HUMAN	Decreases Response To Substance	[142]
Poly polymerase 1 (PARP1)	OTIESHK4	PARP1_ARATH	Increases ADR	[34]
Cadherin-11 (CDH11)	OTIZKPTF	CAD11_HUMAN	Increases ADR	[34]
Histidine decarboxylase (hdc)	OTM3771T	DCHS_RAOOR	Increases ADR	[34]
Ornithine decarboxylase (ODC1)	OTNDAGRR	DCOR_HUMAN	Increases ADR	[34]
Glutathione S-transferase Mu 1 (GSTM1)	OTSBF2MO	GSTM1_HUMAN	Decreases Response To Substance	[148]
Interferon alpha-7 (IFNA7)	OTSQ6R46	IFNA7_HUMAN	Increases ADR	[34]
Polymerase delta-interacting protein 3 (POLDIP3)	OTTB5SV7	PDIP3_HUMAN	Increases Response To Substance	[35]
Alpha-2-HS-glycoprotein (AHSG)	OTUG0LEA	FETUA_HUMAN	Increases Response To Substance	[35]
Progranulin (GRN)	OTXXSJ53	GRN_HUMAN	Decreases Response To Substance	[149]
Calcitonin (CALCA)	OTZ11LHB	CALC_HUMAN	Decreases Response To Substance	[150]
Alkaline phosphatase, placental type (ALPP)	OTZU4G9W	PPB1_HUMAN	Increases ADR	[34]

Indication(s) of MK-4827

Disease Entry	ICD 11	Status	REF
Ovarian cancer	2C73	Phase 3	[5]
Breast cancer	2C60-2C65	Phase 2	[6]
Ewing sarcoma	2B52	Phase 1	[6]

MK-4827 Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Poly [ADP-ribose] polymerase (PARP)	TTEBCY8	NOUNIPROTAC	Modulator	[151]

MK-4827 Interacts with 3 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 1A1 (CYP1A1)	DE6OQ3W	CP1A1_HUMAN	Metabolism	[152]
Carboxylesterase 1 (CES1)	DEB30C5	EST1_HUMAN	Metabolism	[153]
Beta-glucuronidase (GUSB)	DEP54UE	BGLR_HUMAN	Metabolism	[153]

MK-4827 Interacts with 1 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Expression	[154]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Breast carcinoma	DC1VFXJ	KPL1	Investigative	[155]
Colon adenocarcinoma	DCOFOQN	LOVO	Investigative	[155]
Colon carcinoma	DCMNRKP	RKO	Investigative	[155]
Rectal adenocarcinoma	DCNH5AF	SW837	Investigative	[155]
Adenocarcinoma	DC1TL9N	CAOV3	Investigative	[1]
Adenocarcinoma	DCV0P5Q	NCIH2122	Investigative	[1]
Adenocarcinoma	DCC74UJ	COLO320DM	Investigative	[1]
Adenocarcinoma	DCNBUQE	DLD1	Investigative	[1]
Adenocarcinoma	DC61OFO	HCT116	Investigative	[1]
Malignant melanoma	DC8DMA4	A375	Investigative	[1]
Malignant melanoma	DC11AG5	SKMEL30	Investigative	[1]
Non small cell carcinoma	DCTMZKH	SKMES1	Investigative	[1]

References

• [1] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [2] Dexamethasone FDA Label
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3447).
• [4] Dexamethasone in Hospitalized Patients with Covid-19 - Preliminary Report. N Engl J Med. 2020 Jul 17. doi: 10.1056/NEJMoa2021436.
• [5] ClinicalTrials.gov (NCT03602859) A Phase 3 Comparison of Platinum-based Therapy With TSR-042 and Niraparib Versus Standard of Care (SOC) Platinum-based Therapy as First-line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian Cancer (FIRST). U.S. National Institutes of Health.
• [6] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [7] Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
• [8] Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1. Mol Pharmacol. 2005 Mar;67(3):845-55.
• [9] Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
• [10] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [11] Dexamethasone inhibits pancreatic tumor growth in preclinical models: Involvement of activating glucocorticoid receptor. Toxicol Appl Pharmacol. 2020 Aug 15;401:115118. doi: 10.1016/j.taap.2020.115118. Epub 2020 Jul 1.
• [12] Regulation of VDR expression in rat and human intestine and liver--consequences for CYP3A expression. Toxicol In Vitro. 2010 Apr;24(3):822-9. doi: 10.1016/j.tiv.2009.12.011. Epub 2009 Dec 13.
• [13] NF-kappaB activation for constitutive expression of VCAM-1 and ICAM-1 on B lymphocytes and plasma cells. Biochem Biophys Res Commun. 2001 Dec 14;289(4):851-6. doi: 10.1006/bbrc.2001.6067.
• [14] Glucocorticoids inhibit cell death in ovarian cancer and up-regulate caspase inhibitor cIAP2. Clin Cancer Res. 2005 Sep 1;11(17):6325-32. doi: 10.1158/1078-0432.CCR-05-0182.
• [15] Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells. Environ Health Perspect. 2015 Jan;123(1):80-7. doi: 10.1289/ehp.1408437. Epub 2014 Aug 19.
• [16] Interaction between the glucocorticoid and erythropoietin receptors in human erythroid cells. Exp Hematol. 2009 May;37(5):559-72.
• [17] Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol. Biochem J. 2007 Jan 15;401(2):597-605.
• [18] Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells. Arch Pharm Res. 2007 Apr;30(4):507-18.
• [19] Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes. Br J Clin Pharmacol. 1996 Mar;41(3):187-90.
• [20] Regulation of CYP3A5 by glucocorticoids and cigarette smoke in human lung-derived cells. J Pharmacol Exp Ther. 2003 Feb;304(2):745-52.
• [21] Cytotoxicity of chloroacetanilide herbicide alachlor in HepG2 cells independent of CYP3A4 and CYP3A7. Food Chem Toxicol. 2007 May;45(5):871-7.
• [22] In vitro metabolism of dexamethasone cipecilate, a novel synthetic corticosteroid, in human liver and nasal mucosa. Xenobiotica. 2011 Oct;41(10):874-84.
• [23] Metabolism of synthetic steroids by the human placenta. Placenta. 2007 Jan;28(1):39-46.
• [24] A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro. Xenobiotica. 1999 Mar;29(3):269-79.
• [25] SGK1, a potential regulator of c-fms related breast cancer aggressiveness. Clin Exp Metastasis. 2004;21(6):477-83.
• [26] Induction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell line. Am J Respir Cell Mol Biol. 2000 Mar;22(3):360-6.
• [27] Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):86-96.
• [28] Dexamethasone differentially regulates expression of carboxylesterase genes in humans and rats. Drug Metab Dispos. 2000 Feb;28(2):186-91.
• [29] Influence of different chemicals on MDR-1 P-glycoprotein expression and activity in the HK-2 proximal tubular cell line. Toxicol Appl Pharmacol. 2002 Sep 1;183(2):83-91.
• [30] Effects of theophylline, dexamethasone and salbutamol on cytokine gene expression in human peripheral blood CD4+ T-cells. Eur Respir J. 1999 Nov;14(5):1106-12. doi: 10.1183/09031936.99.14511069.
• [31] Anti-diabetic effect of oligosaccharides from seaweed Sargassum confusum via JNK-IRS1/PI3K signalling pathways and regulation of gut microbiota. Food Chem Toxicol. 2019 Sep;131:110562. doi: 10.1016/j.fct.2019.110562. Epub 2019 Jun 7.
• [32] Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone. Blood. 2004 Apr 15;103(8):3138-47. doi: 10.1182/blood-2003-05-1543. Epub 2003 Dec 24.
• [33] Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. Mol Cell. 2006 Nov 3;24(3):341-54. doi: 10.1016/j.molcel.2006.10.019.
• [34] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [35] Mechanisms of dexamethasone-induced disturbed sleep and fatigue in paediatric patients receiving treatment for ALL. Eur J Cancer. 2010 Jul;46(10):1848-55. doi: 10.1016/j.ejca.2010.03.026. Epub 2010 Apr 17.
• [36] Effects of nitroglycerin and dexamethasone on nitric oxide and endothelin derived from alveolar macrophages in patients with mild and middle asthma. Hunan Yi Ke Da Xue Xue Bao. 2000 Aug 28;25(4):363-6.
• [37] Co-culture of primary human mammary fibroblasts and MCF-7 cells as an in vitro breast cancer model. Toxicol Sci. 2005 Feb;83(2):257-63.
• [38] Expression and induction potential of cytochromes P450 in human cryopreserved hepatocytes. Drug Metab Dispos. 2005 Jul;33(7):1004-16.
• [39] Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha. Mol Pharmacol. 2005 Sep;68(3):747-57.
• [40] Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor. Mol Pharmacol. 2006 Jul;70(1):329-39.
• [41] The modulation of aromatase and estrogen receptor alpha in cultured human dermal papilla cells by dexamethasone: a novel mechanism for selective action of estrogen via estrogen receptor beta? J Invest Dermatol. 2006 Sep;126(9):2010-8.
• [42] Reduction of glucocorticoid receptor ligand binding by the 11-beta hydroxysteroid dehydrogenase type 2 inhibitor, Thiram. Steroids. 2006 Oct;71(10):895-901.
• [43] An evidence for regulatory cross-talk between aryl hydrocarbon receptor and glucocorticoid receptor in HepG2 cells. Physiol Res. 2008;57(3):427-35.
• [44] Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoter. Mol Pharmacol. 2008 Feb;73(2):451-60.
• [45] Glucocorticoid receptor-mediated upregulation of human CYP27A1, a potential anti-atherogenic enzyme. Biochim Biophys Acta. 2008 Nov-Dec;1781(11-12):718-23.
• [46] Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes. Chem Biol Interact. 2009 May 15;179(2-3):288-96.
• [47] Expression and regulation of the bile acid transporter, OSTalpha-OSTbeta in rat and human intestine and liver. Biopharm Drug Dispos. 2009 Jul;30(5):241-58.
• [48] Development of stably transfected human and rat hepatoma cell lines for the species-specific assessment of xenobiotic response enhancer module (XREM)-dependent induction of drug metabolism. Toxicology. 2010 Nov 9;277(1-3):11-9.
• [49] The role of lithocholic acid in the regulation of bile acid detoxication, synthesis, and transport proteins in rat and human intestine and liver slices. Toxicol In Vitro. 2011 Feb;25(1):80-90.
• [50] CYP2S1 is negatively regulated by corticosteroids in human cell lines. Toxicol Lett. 2012 Feb 25;209(1):30-4.
• [51] Low-dose methotrexate inhibits methionine S-adenosyltransferase in vitro and in vivo. Mol Med. 2012 May 9;18:423-32.
• [52] Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis. PLoS One. 2012;7(1):e30443.
• [53] The aryl hydrocarbon receptor and glucocorticoid receptor interact to activate human metallothionein 2A. Toxicol Appl Pharmacol. 2013 Nov 15;273(1):90-9.
• [54] Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression. Toxicol Appl Pharmacol. 2014 Oct 1;280(1):138-48.
• [55] Transcriptional regulation of human paraoxonase 1 by PXR and GR in human hepatoma cells. Toxicol In Vitro. 2015 Dec 25;30(1 Pt B):348-54.
• [56] Parathyroid hormone 1-34 reduces dexamethasone-induced terminal differentiation in human articular chondrocytes. Toxicology. 2016 Aug 10;368-369:116-128.
• [57] Dexamethasone induces human glutathione S transferase alpha 1 (hGSTA1) expression through the activation of glucocorticoid receptor (hGR). Toxicology. 2017 Jun 15;385:59-66.
• [58] Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts. Biochem Biophys Res Commun. 2002 Mar 1;291(3):680-6. doi: 10.1006/bbrc.2002.6510.
• [59] Glucocorticoids affect 24 h clock genes expression in human adipose tissue explant cultures. PLoS One. 2012;7(12):e50435. doi: 10.1371/journal.pone.0050435. Epub 2012 Dec 10.
• [60] Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies. Toxicol Appl Pharmacol. 2021 Dec 15;433:115792. doi: 10.1016/j.taap.2021.115792. Epub 2021 Nov 3.
• [61] Down-regulation of signal transducer and activator of transcription 3 expression using vector-based small interfering RNAs suppresses growth of human prostate tumor in vivo. Clin Cancer Res. 2005 Sep 1;11(17):6333-41. doi: 10.1158/1078-0432.CCR-05-0148.
• [62] Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4 upregulation in primary human hepatocytes. Pharmacol Rep. 2013;65(5):1322-35. doi: 10.1016/s1734-1140(13)71491-9.
• [63] Dexamethasone affects Fas- and serum deprivation-induced cell death of human osteoblastic cells through survivin regulation. Int J Immunopathol Pharmacol. 2010 Oct-Dec;23(4):1153-65. doi: 10.1177/039463201002300419.
• [64] Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Arch Toxicol. 2020 Dec;94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. Epub 2020 Aug 17.
• [65] Differential regulation of the human MRP2 and MRP3 gene expression by glucocorticoids. J Steroid Biochem Mol Biol. 2005 Aug;96(3-4):229-34. doi: 10.1016/j.jsbmb.2005.03.004.
• [66] Glucocorticoid regulation of human eosinophil gene expression. J Steroid Biochem Mol Biol. 2003 Mar;84(4):441-52. doi: 10.1016/s0960-0760(03)00065-7.
• [67] Influence of resveratrol on rheumatoid fibroblast-like synoviocytes analysed with gene chip transcription. Phytomedicine. 2013 Feb 15;20(3-4):310-8. doi: 10.1016/j.phymed.2012.09.020. Epub 2012 Nov 6.
• [68] G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress. Endocrinology. 2016 Aug;157(8):3002-8. doi: 10.1210/en.2016-1245. Epub 2016 Jun 14.
• [69] Dickkopf 1 mediates glucocorticoid-induced changes in human neural progenitor cell proliferation and differentiation. Toxicol Sci. 2012 Feb;125(2):488-95. doi: 10.1093/toxsci/kfr304. Epub 2011 Nov 1.
• [70] Identification of novel human CTL epitopes and their agonist epitopes of mesothelin. Clin Cancer Res. 2005 Sep 1;11(17):6342-51. doi: 10.1158/1078-0432.CCR-05-0596.
• [71] The effects of bisphenol A and bisphenol S on adipokine expression and glucose metabolism in human adipose tissue. Toxicology. 2020 Dec 1;445:152600. doi: 10.1016/j.tox.2020.152600. Epub 2020 Sep 22.
• [72] Male pseudohermaphroditism with hypertension due to a 17alpha-hydroxylation deficiency. Clin Endocrinol (Oxf). 1976 Jan;5(1):53-61.
• [73] Inhibition of PARP1 Increases IRF-dependent Gene Transcription in Jurkat Cells. Curr Med Sci. 2019 Jun;39(3):356-362. doi: 10.1007/s11596-019-2043-1. Epub 2019 Jun 17.
• [74] Effects of inhaled beclomethasone compared to systemic dexamethasone on lung inflammation in preterm infants at risk of chronic lung disease. Pediatr Pulmonol. 1999 Jun;27(6):383-7. doi: 10.1002/(sici)1099-0496(199906)27:6<383::aid-ppul4>3.0.co;2-v.
• [75] miR-148a/LDLR mediates hypercholesterolemia induced by prenatal dexamethasone exposure in male offspring rats. Toxicol Appl Pharmacol. 2020 May 15;395:114979. doi: 10.1016/j.taap.2020.114979. Epub 2020 Mar 29.
• [76] Role of endogenous TGF-beta in glucocorticoid-induced lung type II cell differentiation. Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L249-57. doi: 10.1152/ajplung.00088.2006. Epub 2006 Sep 22.
• [77] Cyclic changes in the expression of p57(kip2) in human endometrium and its regulation by steroid hormones in endometrial stromal cells in vitro. Reprod Sci. 2012 Jan;19(1):92-101. doi: 10.1177/1933719111414209. Epub 2011 Nov 7.
• [78] Effect of dexamethasone on insulin sensitivity, islet amyloid polypeptide and insulin secretion in humans. Diabetologia. 1993 Jan;36(1):84-7. doi: 10.1007/BF00399099.
• [79] Differential effect of thalidomide and dexamethasone on the transcription factor NF-kappa B. Int Immunopharmacol. 2001 Jan;1(1):49-61. doi: 10.1016/s0162-3109(00)00265-4.
• [80] Glucocorticoid-mediated inhibition of interleukin-2 receptor alpha and -beta subunit expression by human T cells. Immunopharmacology. 1994 Jan-Feb;27(1):43-55. doi: 10.1016/0162-3109(94)90006-x.
• [81] Chemotaxis of human CD4+ eosinophils. Int Arch Allergy Immunol. 2001;125 Suppl 1:19-21. doi: 10.1159/000053847.
• [82] Sulfur mustard alkylates steroid hormones and impacts hormone function in vitro. Arch Toxicol. 2019 Nov;93(11):3141-3152. doi: 10.1007/s00204-019-02571-x. Epub 2019 Sep 12.
• [83] Effect of topical Ginkgo biloba extract on steroid-induced changes in the trabecular meshwork and intraocular pressure. Arch Ophthalmol. 2008 Dec;126(12):1700-6. doi: 10.1001/archophthalmol.2008.512.
• [84] Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism. Br J Pharmacol. 2000 May;130(2):289-98. doi: 10.1038/sj.bjp.0703272.
• [85] Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation. Carcinogenesis. 2009 Feb;30(2):348-55. doi: 10.1093/carcin/bgn266. Epub 2008 Nov 26.
• [86] Dexamethasone administration inhibits skeletal muscle expression of the androgen receptor and IGF-1--implications for steroid-induced myopathy. Clin Endocrinol (Oxf). 2010 Jul;73(1):126-32. doi: 10.1111/j.1365-2265.2009.03683.x. Epub 2009 Aug 4.
• [87] 1 alpha,25-(OH)2 vitamin D3 enhances expression of the genes encoding Ca(2+)-binding proteins MRP-8 and MRP-14. Am J Physiol. 1992 Jan;262(1 Pt 1):C235-42. doi: 10.1152/ajpcell.1992.262.1.C235.
• [88] Simvastatin suppresses dexamethasone-induced secretion of plasminogen activator inhibitor-1 in human bone marrow adipocytes. BMC Musculoskelet Disord. 2011 Apr 27;12(1):82. doi: 10.1186/1471-2474-12-82.
• [89] Dexamethasone can stimulate G1-S phase transition in human airway fibroblasts in asthma. Eur Respir J. 2006 Jun;27(6):1160-7. doi: 10.1183/09031936.06.00078605. Epub 2006 Mar 1.
• [90] Glucocorticoids induce beta2-adrenergic receptor function in human nasal mucosa. Am J Respir Crit Care Med. 1997 Feb;155(2):704-10. doi: 10.1164/ajrccm.155.2.9032216.
• [91] Withaferin A: A potential selective glucocorticoid receptor modulator with anti-inflammatory effect. Food Chem Toxicol. 2023 Sep;179:113949. doi: 10.1016/j.fct.2023.113949. Epub 2023 Jul 17.
• [92] Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells. J Leukoc Biol. 1999 Dec;66(6):909-14. doi: 10.1002/jlb.66.6.909.
• [93] Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells. Biochem J. 1991 Aug 1;277 ( Pt 3)(Pt 3):659-64. doi: 10.1042/bj2770659.
• [94] Glucocorticoids exert direct toxicity on microvasculature: analysis of cell death mechanisms. Toxicol Sci. 2015 Feb;143(2):441-53. doi: 10.1093/toxsci/kfu243. Epub 2014 Dec 1.
• [95] Molecular analysis of the inhibition of interleukin-8 production by dexamethasone in a human fibrosarcoma cell line. Immunology. 1992 Apr;75(4):674-9.
• [96] Regulation of messenger RNAs for the hydrophobic surfactant proteins in human lung. J Clin Invest. 1989 Apr;83(4):1191-7. doi: 10.1172/JCI114000.
• [97] Prenatal dexamethasone exposure caused fetal rats liver dysplasia by inhibiting autophagy-mediated cell proliferation. Toxicology. 2021 Feb 15;449:152664. doi: 10.1016/j.tox.2020.152664. Epub 2021 Jan 5.
• [98] Bone microenvironment-related growth factors, zoledronic acid and dexamethasone differentially modulate PTHrP expression in PC-3 prostate cancer cells. Horm Metab Res. 2005 Oct;37(10):593-601. doi: 10.1055/s-2005-870525.
• [99] Activation of coagulation by lenalidomide-based regimens for the treatment of multiple myeloma. PLoS One. 2013 May 16;8(5):e64369. doi: 10.1371/journal.pone.0064369. Print 2013.
• [100] Negative regulation of hepatocyte growth factor gene expression in human lung fibroblasts and leukemic cells by transforming growth factor-beta 1 and glucocorticoids. J Biol Chem. 1992 Dec 15;267(35):24917-20.
• [101] Muc-1 core protein is expressed on multiple myeloma cells and is induced by dexamethasone. Blood. 1999 Feb 15;93(4):1287-98.
• [102] PKA-dependent growth stimulation of cells derived from human pulmonary adenocarcinoma and small airway epithelium by dexamethasone. Eur J Cancer. 2005 Nov;41(17):2745-53. doi: 10.1016/j.ejca.2005.09.001. Epub 2005 Oct 18.
• [103] Induction of the DNA repair gene O6-methylguanine-DNA methyltransferase by dexamethasone in glioblastomas. J Neurosurg. 2004 Oct;101(4):659-63. doi: 10.3171/jns.2004.101.4.0659.
• [104] The myeloma cell antigen syndecan-1 is lost by apoptotic myeloma cells. Br J Haematol. 1998 Mar;100(4):637-46. doi: 10.1046/j.1365-2141.1998.00623.x.
• [105] Functional characterization of an orphan nuclear receptor, Rev-ErbAalpha, in chondrocytes and its potential role in osteoarthritis. Arthritis Rheum. 2006 Nov;54(11):3513-22. doi: 10.1002/art.22170.
• [106] CDK2 is involved in the S-phase lengthening induced by glucocorticoids in normal human lymphocytes. Eur J Cell Biol. 2003 May;82(5):253-61. doi: 10.1078/0171-9335-00298.
• [107] Neuroendocrine mediators up-regulate alpha1b- and alpha1d-adrenergic receptor subtypes in human monocytes. J Neuroimmunol. 1999 Mar 1;95(1-2):165-73. doi: 10.1016/s0165-5728(99)00011-9.
• [108] Sex steroids used in hormonal treatment increase vascular procoagulant activity by inducing thrombin receptor (PAR-1) expression: role of the glucocorticoid receptor. Circulation. 2001 Dec 4;104(23):2826-31. doi: 10.1161/hc4801.099737.
• [109] [A study on the heterogeneous apoptosis of lymphocytes, eosinophils, and neutrophils from peripheral blood of asthmatic patients]. Zhonghua Jie He He Hu Xi Za Zhi. 2003 Oct;26(10):610-4.
• [110] Dexamethasone suppresses DU145 cell proliferation and cell cycle through inhibition of the extracellular signal-regulated kinase 1/2 pathway and cyclin D1 expression. Asian J Androl. 2008 Jul;10(4):635-41. doi: 10.1111/j.1745-7262.2008.00352.x. Epub 2007 Dec 20.
• [111] Chromosomal radiosensitivity in two cell lineages derived from clinically radiosensitive cancer patients. Clin Cancer Res. 2005 Sep 1;11(17):6352-8. doi: 10.1158/1078-0432.CCR-04-1931.
• [112] Anti-inflammatory drugs suppress proliferation and induce apoptosis through altering expressions of cell cycle regulators and pro-apoptotic factors in cultured human osteoblasts. Toxicology. 2009 Apr 28;258(2-3):148-56. doi: 10.1016/j.tox.2009.01.016. Epub 2009 Jan 22.
• [113] Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-phosphatidylinositol 3'-kinase signaling pathway. Endocrinology. 2005 Mar;146(3):1391-7. doi: 10.1210/en.2004-1152. Epub 2004 Dec 2.
• [114] Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway. Blood. 2006 Apr 15;107(8):3221-8. doi: 10.1182/blood-2005-07-2843. Epub 2005 Dec 15.
• [115] Theophylline and dexamethasone induce peroxisome proliferator-activated receptor-gamma expression in human eosinophils. Pharmacology. 2006;77(1):33-7. doi: 10.1159/000092376. Epub 2006 Mar 29.
• [116] Leptin production in adipocytes from morbidly obese subjects: stimulation by dexamethasone, inhibition with troglitazone, and influence of gender. J Clin Endocrinol Metab. 2000 Aug;85(8):2678-84. doi: 10.1210/jcem.85.8.6733.
• [117] Differential effect of dexamethasone on cell death and STAT5 activation during in vitro eosinopoiesis. Br J Haematol. 2003 Dec;123(5):933-41. doi: 10.1046/j.1365-2141.2003.04700.x.
• [118] Dexamethasone inhibits spontaneous apoptosis in primary cultures of human and rat hepatocytes via Bcl-2 and Bcl-xL induction. Cell Death Differ. 2001 Mar;8(3):279-88. doi: 10.1038/sj.cdd.4400815.
• [119] Prostaglandin E2 and dexamethasone inhibit IL-12 receptor expression and IL-12 responsiveness. J Immunol. 1998 Sep 15;161(6):2723-30.
• [120] Inhibitory effect of glucocorticoids on human-cloned 5-hydroxytryptamine3A receptor expressed in xenopus oocytes. Anesthesiology. 2004 Sep;101(3):660-5. doi: 10.1097/00000542-200409000-00014.
• [121] MiR-17-5p/FOXL2/CDKN1B signal programming in oocytes mediates transgenerational inheritance of diminished ovarian reserve in female offspring rats induced by prenatal dexamethasone exposure. Cell Biol Toxicol. 2023 Jun;39(3):867-883. doi: 10.1007/s10565-021-09645-6. Epub 2021 Sep 19.
• [122] p38 Mitogen-activated protein kinase (MAPK) is a key mediator in glucocorticoid-induced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211. Mol Endocrinol. 2005 Jun;19(6):1569-83. doi: 10.1210/me.2004-0528. Epub 2005 Apr 7.
• [123] Inhibitory effect of glucocorticoid for osteoblast apoptosis induced by activated peripheral blood mononuclear cells. Endocrinology. 1998 Apr;139(4):2032-40. doi: 10.1210/endo.139.4.5932.
• [124] Dexamethasone increases fluid absorption via Na+/H+ exchanger (NHE) 3 activation in normal human middle ear epithelial cells. Eur J Pharmacol. 2006 Apr 24;536(1-2):12-8. doi: 10.1016/j.ejphar.2006.02.031. Epub 2006 Feb 28.
• [125] Low H3K27 acetylation of SF1 in PBMC: a biomarker for prenatal dexamethasone exposure-caused adrenal insufficiency of steroid synthesis in male offspring. Cell Biol Toxicol. 2023 Oct;39(5):2051-2067. doi: 10.1007/s10565-021-09691-0. Epub 2022 Mar 4.
• [126] Bisphenol A induces differentiation of human preadipocytes in the absence of glucocorticoid and is inhibited by an estrogen-receptor antagonist. Nutr Diabetes. 2014 Jan 13;4(1):e102. doi: 10.1038/nutd.2013.43.
• [127] Modification of biophysical properties of lung epithelial Na(+) channels by dexamethasone. Am J Physiol Cell Physiol. 2000 Sep;279(3):C762-70. doi: 10.1152/ajpcell.2000.279.3.C762.
• [128] [Inhibitory effects of Galectin-3 on the inflammatory cytokines and chemokines in guinea pig asthma models]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 May;36(3):355-8.
• [129] Regulation of type III iodothyronine deiodinase expression in human cell lines. Endocrinology. 2006 Dec;147(12):5845-54. doi: 10.1210/en.2006-0590. Epub 2006 Aug 24.
• [130] Apoptosis of airway epithelial cells induced by corticosteroids. Am J Respir Crit Care Med. 2001 Nov 15;164(10 Pt 1):1939-47. doi: 10.1164/ajrccm.164.10.2103013.
• [131] IL-10 synergizes with dexamethasone in inhibiting human T cell proliferation. J Pharmacol Exp Ther. 1998 May;285(2):915-9.
• [132] CXCR4 expression on monocytes is up-regulated by dexamethasone and is modulated by autologous CD3+ T cells. Immunology. 2002 Feb;105(2):155-62. doi: 10.1046/j.0019-2805.2001.01359.x.
• [133] Subacute myelopathy: an unusual paraneoplastic complication of Hodgkin's disease. Med Pediatr Oncol. 1988;16(4):284-6. doi: 10.1002/mpo.2950160413.
• [134] A Gene Expression Biomarker Predicts Heat Shock Factor 1 Activation in a Gene Expression Compendium. Chem Res Toxicol. 2021 Jul 19;34(7):1721-1737. doi: 10.1021/acs.chemrestox.0c00510. Epub 2021 Jun 25.
• [135] The glucocorticoid receptor is associated with the RNA-binding nuclear matrix protein hnRNP U. J Biol Chem. 1997 Nov 7;272(45):28471-8. doi: 10.1074/jbc.272.45.28471.
• [136] Dexamethasone inhibits TRAIL-induced apoptosis of thyroid cancer cells via Bcl-xL induction. Eur J Cancer. 2006 Dec;42(18):3287-93. doi: 10.1016/j.ejca.2006.07.018. Epub 2006 Oct 27.
• [137] Role of caspases in dexamethasone-induced apoptosis and activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase in human eosinophils. Clin Exp Immunol. 2000 Oct;122(1):20-7. doi: 10.1046/j.1365-2249.2000.01344.x.
• [138] Promoter polymorphism influences the effect of dexamethasone on transcriptional activation of the LTC4 synthase gene. Eur J Hum Genet. 2003 Aug;11(8):619-22. doi: 10.1038/sj.ejhg.5201015.
• [139] Conditional regulation of the human CYP4X1 and CYP4Z1 genes. Arch Biochem Biophys. 2005 Apr 15;436(2):377-85. doi: 10.1016/j.abb.2005.02.022.
• [140] Induction of aquaporin 3 by corticosteroid in a human airway epithelial cell line. Am J Physiol. 1997 Nov;273(5):L1090-5. doi: 10.1152/ajplung.1997.273.5.L1090.
• [141] Dermal hyaluronan is rapidly reduced by topical treatment with glucocorticoids. J Invest Dermatol. 2010 Jan;130(1):141-9. doi: 10.1038/jid.2009.210.
• [142] Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance. Blood. 2003 Nov 1;102(9):3379-86. doi: 10.1182/blood-2003-05-1417. Epub 2003 Jul 10.
• [143] Activation of GR but not PXR by dexamethasone attenuated acetaminophen hepatotoxicities via Fgf21 induction. Toxicology. 2017 Mar 1;378:95-106. doi: 10.1016/j.tox.2017.01.009. Epub 2017 Jan 11.
• [144] [Effect of human recombinant PDCD5 protein on cell apoptosis of multiple myeloma KM3 cells induced by dexamethasone and its mechanism]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Jul;35(7):725-31. doi: 10.3969/j.issn.1672-7347.2010.07.013.
• [145] IMP dehydrogenase inhibitor mycophenolate mofetil induces caspase-dependent apoptosis and cell cycle inhibition in multiple myeloma cells. Mol Cancer Ther. 2006 Feb;5(2):457-66. doi: 10.1158/1535-7163.MCT-05-0340.
• [146] Important role of caspase-8 for chemosensitivity of ALL cells. Clin Cancer Res. 2011 Dec 15;17(24):7605-13. doi: 10.1158/1078-0432.CCR-11-0513. Epub 2011 Oct 18.
• [147] Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance. J Clin Invest. 1991 Feb;87(2):680-6. doi: 10.1172/JCI115046.
• [148] Glutathione S-transferase M1 inhibits dexamethasone-induced apoptosis in association with the suppression of Bim through dual mechanisms in a lymphoblastic leukemia cell line. Cancer Sci. 2010 Mar;101(3):767-73. doi: 10.1111/j.1349-7006.2009.01432.x. Epub 2010 Jan 7.
• [149] PC cell-derived growth factor confers resistance to dexamethasone and promotes tumorigenesis in human multiple myeloma. Clin Cancer Res. 2006 Jan 1;12(1):49-56. doi: 10.1158/1078-0432.CCR-05-0929.
• [150] Calcitonin induces apoptosis resistance in prostate cancer cell lines against cytotoxic drugs via the Akt/survivin pathway. Cancer Biol Ther. 2005 Nov;4(11):1226-33. doi: 10.4161/cbt.4.11.2093. Epub 2005 Nov 5.
• [151] Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
• [152] Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. J Med Chem. 2009 Nov 26;52(22):7170-85.
• [153] Summary of FDA-approved anticancer cytotoxic drugs at May 2019.
• [154] Autophagy up-regulated by MEK/ERK promotes the repair of DNA damage caused by aflatoxin B1. Toxicol Mech Methods. 2022 Feb;32(2):87-96. doi: 10.1080/15376516.2021.1968985. Epub 2021 Aug 26.
• [155] Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.